RABEP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.34414896
2synaptic vesicle maturation (GO:0016188)5.10706048
3locomotory exploration behavior (GO:0035641)4.87089919
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.52469393
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.46589331
6layer formation in cerebral cortex (GO:0021819)4.39039371
7vocalization behavior (GO:0071625)4.33306731
8synaptic vesicle exocytosis (GO:0016079)4.28400997
9nuclear pore complex assembly (GO:0051292)4.27927696
10glutamate secretion (GO:0014047)4.19263367
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.18962348
12regulation of synaptic vesicle exocytosis (GO:2000300)4.12166088
13regulation of glutamate receptor signaling pathway (GO:1900449)4.10557515
14regulation of NFAT protein import into nucleus (GO:0051532)4.07244345
15establishment of mitochondrion localization (GO:0051654)3.92672116
16protein localization to synapse (GO:0035418)3.88983992
17exploration behavior (GO:0035640)3.86866265
18ionotropic glutamate receptor signaling pathway (GO:0035235)3.83590173
19neuron cell-cell adhesion (GO:0007158)3.80894985
20neurotransmitter secretion (GO:0007269)3.76861257
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.72801276
22gamma-aminobutyric acid transport (GO:0015812)3.70541503
23dendrite morphogenesis (GO:0048813)3.69345855
24regulation of synapse structural plasticity (GO:0051823)3.68892638
25regulation of synaptic vesicle transport (GO:1902803)3.67673000
26nuclear pore organization (GO:0006999)3.63923319
27neurotransmitter-gated ion channel clustering (GO:0072578)3.62460590
28regulation of long-term neuronal synaptic plasticity (GO:0048169)3.62340694
29proline transport (GO:0015824)3.61800415
30regulation of neuronal synaptic plasticity (GO:0048168)3.61335875
31sarcoplasmic reticulum calcium ion transport (GO:0070296)3.59404540
32establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.58968108
33mitochondrion transport along microtubule (GO:0047497)3.58968108
34glutamate receptor signaling pathway (GO:0007215)3.57518411
35synaptic vesicle docking involved in exocytosis (GO:0016081)3.56521499
36mitotic sister chromatid cohesion (GO:0007064)3.56420709
37dendritic spine morphogenesis (GO:0060997)3.54128157
38neuron recognition (GO:0008038)3.41060593
39neuronal action potential propagation (GO:0019227)3.39784454
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.37205358
41regulation of RNA export from nucleus (GO:0046831)3.35044604
42negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.33561713
43cellular potassium ion homeostasis (GO:0030007)3.30127527
44pore complex assembly (GO:0046931)3.28568360
45vesicle transport along microtubule (GO:0047496)3.27034935
46axonal fasciculation (GO:0007413)3.24464854
47regulation of dendritic spine morphogenesis (GO:0061001)3.24131260
48activation of protein kinase A activity (GO:0034199)3.16914756
49negative regulation of neurotransmitter secretion (GO:0046929)3.14016278
50synaptic transmission, glutamatergic (GO:0035249)3.14000761
51cerebellar Purkinje cell differentiation (GO:0021702)3.12615705
52neuron-neuron synaptic transmission (GO:0007270)3.12552954
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.11852585
54neuromuscular process controlling balance (GO:0050885)3.11474403
55long-term memory (GO:0007616)3.09943520
56regulation of nucleobase-containing compound transport (GO:0032239)3.08824944
57clathrin coat assembly (GO:0048268)3.07611157
58positive regulation of synapse maturation (GO:0090129)3.07155338
59dosage compensation (GO:0007549)3.06339250
60L-amino acid import (GO:0043092)3.05789243
61synaptic vesicle endocytosis (GO:0048488)3.05203890
62regulation of clathrin-mediated endocytosis (GO:2000369)3.05163960
63neuronal ion channel clustering (GO:0045161)3.01622818
64sodium ion export (GO:0071436)3.01279266
65organelle transport along microtubule (GO:0072384)2.99522581
66regulation of postsynaptic membrane potential (GO:0060078)2.98762917
67negative regulation of potassium ion transmembrane transport (GO:1901380)2.97917061
68neurotransmitter transport (GO:0006836)2.97850805
69innervation (GO:0060384)2.94878501
70prepulse inhibition (GO:0060134)2.93860996
71cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.93208305
72mating behavior (GO:0007617)2.89413664
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.88716659
74regulation of dendritic spine development (GO:0060998)2.88175599
75cell communication by electrical coupling (GO:0010644)2.87553766
76gamma-aminobutyric acid signaling pathway (GO:0007214)2.86373180
77regulation of synaptic plasticity (GO:0048167)2.85151953
78establishment of nucleus localization (GO:0040023)2.82748892
79cell migration in hindbrain (GO:0021535)2.82384628
80cellular response to catecholamine stimulus (GO:0071870)2.82292964
81cellular response to monoamine stimulus (GO:0071868)2.82292964
82peptidyl-threonine phosphorylation (GO:0018107)2.82054267
83pyrimidine nucleobase catabolic process (GO:0006208)2.81986500
84regulation of synaptic transmission, glutamatergic (GO:0051966)2.81270534
85cerebellar Purkinje cell layer development (GO:0021680)2.80726774
86regulation of ARF protein signal transduction (GO:0032012)2.79806477
87regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.79721150
88regulation of neurotransmitter levels (GO:0001505)2.79659723
89regulation of cAMP-dependent protein kinase activity (GO:2000479)2.79530284
90transmission of nerve impulse (GO:0019226)2.79397124
91alanine transport (GO:0032328)2.78834121
92positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.78553370
93nucleus localization (GO:0051647)2.77060180
94peptidyl-threonine modification (GO:0018210)2.76100569
95nerve growth factor signaling pathway (GO:0038180)2.74023844
96membrane depolarization during action potential (GO:0086010)2.74009129
97histone H2B ubiquitination (GO:0033523)2.73489323
98G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73298384
99positive regulation of dendritic spine morphogenesis (GO:0061003)2.73176657
100muscle filament sliding (GO:0030049)2.71097480
101actin-myosin filament sliding (GO:0033275)2.71097480
102positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.70668694
103long-term synaptic potentiation (GO:0060291)2.70606919
104neuron projection extension (GO:1990138)2.69671719
105regulation of neurotransmitter secretion (GO:0046928)2.69513583
106regulation of vesicle fusion (GO:0031338)2.68457077
107response to auditory stimulus (GO:0010996)2.66375560
108glucocorticoid receptor signaling pathway (GO:0042921)2.65814500
109positive regulation of dendritic spine development (GO:0060999)2.65696844
110cerebellar granule cell differentiation (GO:0021707)2.64794664
111synapse assembly (GO:0007416)2.64605406
112positive regulation of membrane potential (GO:0045838)2.64551029
113regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.64319705
114cytoplasmic mRNA processing body assembly (GO:0033962)2.62253534
115negative regulation of microtubule polymerization (GO:0031115)2.62122495
116positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.61336829
117positive regulation of synaptic transmission, GABAergic (GO:0032230)2.60659221
118membrane depolarization (GO:0051899)2.57793845
119NLS-bearing protein import into nucleus (GO:0006607)2.57658280
120central nervous system projection neuron axonogenesis (GO:0021952)2.57235886
121axon extension (GO:0048675)2.56979170
122response to histamine (GO:0034776)2.56968930
123postsynaptic membrane organization (GO:0001941)2.56572886
124regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.55820362
125positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.55820362
126protein targeting to Golgi (GO:0000042)2.54485620
127neuromuscular process (GO:0050905)2.54073436
128histone H3-K9 demethylation (GO:0033169)2.54026947
129interkinetic nuclear migration (GO:0022027)2.53296070
130synapse organization (GO:0050808)2.52964449
131nucleobase catabolic process (GO:0046113)2.52552090
132stress granule assembly (GO:0034063)2.52184859
133social behavior (GO:0035176)2.52004433
134intraspecies interaction between organisms (GO:0051703)2.52004433
135cellular sodium ion homeostasis (GO:0006883)2.50725955
136auditory behavior (GO:0031223)2.50051939
137cerebral cortex radially oriented cell migration (GO:0021799)2.47713897
138presynaptic membrane organization (GO:0097090)2.43740250
139response to parathyroid hormone (GO:0071107)2.41610208
140cytoskeletal anchoring at plasma membrane (GO:0007016)2.41568192
141endoplasmic reticulum organization (GO:0007029)2.40407400
142response to catecholamine (GO:0071869)2.39712111
143response to monoamine (GO:0071867)2.39712111
144regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.39321241
145response to nerve growth factor (GO:1990089)2.38481615
146cellular response to nerve growth factor stimulus (GO:1990090)2.38481615
147amino acid import (GO:0043090)2.37778924
148negative regulation of neurotransmitter transport (GO:0051589)2.37461531
149insulin-like growth factor receptor signaling pathway (GO:0048009)2.34438507
150axon cargo transport (GO:0008088)2.34148656
151regulation of Rac protein signal transduction (GO:0035020)2.33211182
152actin-mediated cell contraction (GO:0070252)2.31872819
153cardiac myofibril assembly (GO:0055003)2.30621855
154myofibril assembly (GO:0030239)2.30300970
155regulation of cell communication by electrical coupling (GO:0010649)2.30221596
156mitochondrion localization (GO:0051646)2.29452900

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.45839391
2GBX2_23144817_ChIP-Seq_PC3_Human3.30071348
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.11745414
4* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.68140427
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44849578
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.41994049
7E2F7_22180533_ChIP-Seq_HELA_Human2.39296678
8WT1_19549856_ChIP-ChIP_CCG9911_Human2.35883557
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.27695579
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26561685
11CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.24620497
12DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.21846973
13REST_21632747_ChIP-Seq_MESCs_Mouse2.14570314
14DROSHA_22980978_ChIP-Seq_HELA_Human2.10683093
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10625388
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10625388
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06107721
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.03064606
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03050124
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00701397
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.99094372
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.94478330
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93045320
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92308958
25SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.88756844
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88059507
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87811805
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.85468507
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.82902463
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.79986046
31AR_21572438_ChIP-Seq_LNCaP_Human1.74880046
32ZNF274_21170338_ChIP-Seq_K562_Hela1.74842940
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74731089
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.74344846
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74099678
36* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.74093407
37SMAD4_21799915_ChIP-Seq_A2780_Human1.71207974
38TAF15_26573619_Chip-Seq_HEK293_Human1.68708314
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67278620
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66358879
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.65829890
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.65756131
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.63589808
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.62931667
45ZFP281_27345836_Chip-Seq_ESCs_Mouse1.62875497
46CTNNB1_20460455_ChIP-Seq_HCT116_Human1.62870251
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60043325
48REST_18959480_ChIP-ChIP_MESCs_Mouse1.59342882
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59279809
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57751871
51KDM2B_26808549_Chip-Seq_K562_Human1.57651634
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.56965204
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55542717
54CLOCK_20551151_ChIP-Seq_293T_Human1.55296053
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50905830
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49658253
57P300_19829295_ChIP-Seq_ESCs_Human1.49573935
58TP53_16413492_ChIP-PET_HCT116_Human1.49349532
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.46727984
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46719143
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.46111358
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.45120630
63STAT3_23295773_ChIP-Seq_U87_Human1.44143612
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43085594
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43017161
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42925731
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41855584
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40995717
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38786027
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.38637448
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38396812
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37896051
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35191802
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.34945254
75AHR_22903824_ChIP-Seq_MCF-7_Human1.32618331
76TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32114503
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31554784
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30860390
79AR_25329375_ChIP-Seq_VCAP_Human1.28937429
80IGF1R_20145208_ChIP-Seq_DFB_Human1.28687947
81REST_19997604_ChIP-ChIP_NEURONS_Mouse1.27566022
82GATA1_26923725_Chip-Seq_HPCs_Mouse1.26115885
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25400073
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25284200
85SOX9_26525672_Chip-Seq_HEART_Mouse1.25066496
86* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24817679
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24457417
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24124263
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23723287
90FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.23561485
91* AR_19668381_ChIP-Seq_PC3_Human1.22479497
92TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.22071561
93* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21632810
94TCF4_23295773_ChIP-Seq_U87_Human1.18671676
95MYC_22102868_ChIP-Seq_BL_Human1.18659381
96ISL1_27105846_Chip-Seq_CPCs_Mouse1.18580470
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18191850
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15807084
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15328295
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14740159
101P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14695515
102* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13805037
103* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13805037
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13574105
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13573476
106* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.12714589
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12398999
108TP53_18474530_ChIP-ChIP_U2OS_Human1.12375983
109KDM2B_26808549_Chip-Seq_JURKAT_Human1.12177720
110CBX2_27304074_Chip-Seq_ESCs_Mouse1.11651574
111WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11457804
112PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09519218
113* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08113322
114KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07888180
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06859011
116FUS_26573619_Chip-Seq_HEK293_Human1.06692236
117BCAT_22108803_ChIP-Seq_LS180_Human1.06681893
118RUNX2_22187159_ChIP-Seq_PCA_Human1.06655184
119ER_23166858_ChIP-Seq_MCF-7_Human1.05418337
120GATA4_21415370_ChIP-Seq_HL-1_Mouse1.04388160
121IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04011807
122MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.02749148
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02327762
124KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01878969
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01796827
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00479721
127KDM2B_26808549_Chip-Seq_DND41_Human0.99523399
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98996838
129MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98957212
130* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98726442
131SALL1_21062744_ChIP-ChIP_HESCs_Human0.98719783
132RING1B_27294783_Chip-Seq_ESCs_Mouse0.98324181
133VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98030298
134TBX20_22328084_ChIP-Seq_HEART_Mouse0.97944429
135TBX20_22080862_ChIP-Seq_HEART_Mouse0.97944429
136MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97495275
137ERG_21242973_ChIP-ChIP_JURKAT_Human0.97232309
138NANOG_18555785_Chip-Seq_ESCs_Mouse0.96811600
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96796181
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96796181
141THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96756559
142EP300_21415370_ChIP-Seq_HL-1_Mouse0.96725278
143ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96505209
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.96287363
145* RING1B_27294783_Chip-Seq_NPCs_Mouse0.96239499
146PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95259557
147STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94918375
148RXR_22108803_ChIP-Seq_LS180_Human0.94158577
149* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94048674
150MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93920927
151SMAD3_21741376_ChIP-Seq_ESCs_Human0.92978802
152P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92908088

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.88088363
2MP0003880_abnormal_central_pattern4.19466081
3MP0003635_abnormal_synaptic_transmissio3.80748676
4MP0004270_analgesia3.50687218
5MP0000569_abnormal_digit_pigmentation3.34931518
6MP0002063_abnormal_learning/memory/cond3.09879997
7MP0009745_abnormal_behavioral_response2.93491056
8MP0008057_abnormal_DNA_replication2.93203509
9MP0009046_muscle_twitch2.78320134
10MP0002064_seizures2.76259210
11MP0009780_abnormal_chondrocyte_physiolo2.69628439
12MP0001968_abnormal_touch/_nociception2.68227101
13MP0002822_catalepsy2.44320135
14MP0002877_abnormal_melanocyte_morpholog2.43451915
15MP0002734_abnormal_mechanical_nocicepti2.42546836
16MP0002572_abnormal_emotion/affect_behav2.39424068
17MP0005423_abnormal_somatic_nervous2.35875294
18MP0001486_abnormal_startle_reflex2.29047040
19MP0001440_abnormal_grooming_behavior2.18230537
20MP0002909_abnormal_adrenal_gland2.15250536
21MP0002272_abnormal_nervous_system2.06827236
22MP0001501_abnormal_sleep_pattern2.06291037
23MP0003329_amyloid_beta_deposits1.99609511
24MP0000778_abnormal_nervous_system1.96867692
25MP0003221_abnormal_cardiomyocyte_apopto1.89773678
26MP0000749_muscle_degeneration1.89078022
27MP0002736_abnormal_nociception_after1.88895565
28MP0002735_abnormal_chemical_nociception1.87788718
29MP0004858_abnormal_nervous_system1.82582596
30MP0005386_behavior/neurological_phenoty1.81630851
31MP0004924_abnormal_behavior1.81630851
32MP0002733_abnormal_thermal_nociception1.79989894
33MP0002067_abnormal_sensory_capabilities1.77012852
34MP0000759_abnormal_skeletal_muscle1.75178987
35MP0004811_abnormal_neuron_physiology1.74364412
36MP0003123_paternal_imprinting1.70768974
37MP0002184_abnormal_innervation1.65906564
38MP0004087_abnormal_muscle_fiber1.63338354
39MP0002009_preneoplasia1.60965218
40MP0000604_amyloidosis1.58262229
41MP0001970_abnormal_pain_threshold1.54894484
42MP0003690_abnormal_glial_cell1.53053327
43MP0002269_muscular_atrophy1.52021289
44MP0004885_abnormal_endolymph1.51914683
45MP0002557_abnormal_social/conspecific_i1.51549993
46MP0003646_muscle_fatigue1.48626435
47MP0003633_abnormal_nervous_system1.48486956
48MP0000955_abnormal_spinal_cord1.47578427
49MP0003787_abnormal_imprinting1.47391819
50MP0008569_lethality_at_weaning1.34258407
51MP0003121_genomic_imprinting1.34169437
52MP0000733_abnormal_muscle_development1.32994979
53MP0006276_abnormal_autonomic_nervous1.32331772
54MP0002066_abnormal_motor_capabilities/c1.29573140
55MP0003631_nervous_system_phenotype1.29457089
56MP0005076_abnormal_cell_differentiation1.26465052
57MP0004130_abnormal_muscle_cell1.26080051
58MP0002882_abnormal_neuron_morphology1.25704205
59MP0005646_abnormal_pituitary_gland1.19399717
60MP0001177_atelectasis1.18428357
61MP0002837_dystrophic_cardiac_calcinosis1.16996857
62MP0002106_abnormal_muscle_physiology1.16897307
63MP0005623_abnormal_meninges_morphology1.15845707
64MP0010234_abnormal_vibrissa_follicle1.15514370
65MP0002090_abnormal_vision1.15323429
66MP0000751_myopathy1.15196635
67MP0004084_abnormal_cardiac_muscle1.14550926
68MP0002332_abnormal_exercise_endurance1.14038349
69MP0000003_abnormal_adipose_tissue1.13825326
70MP0003632_abnormal_nervous_system1.12540608
71MP0003385_abnormal_body_wall1.12413315
72MP0005248_abnormal_Harderian_gland1.12221233
73MP0001299_abnormal_eye_distance/1.10514483
74MP0004185_abnormal_adipocyte_glucose1.10311603
75MP0003634_abnormal_glial_cell1.10006608
76MP0002139_abnormal_hepatobiliary_system1.09210125
77MP0005451_abnormal_body_composition1.08867237
78MP0002152_abnormal_brain_morphology1.06618920
79MP0003091_abnormal_cell_migration1.05341703
80MP0001502_abnormal_circadian_rhythm1.05190266
81MP0004145_abnormal_muscle_electrophysio1.03765361
82MP0003879_abnormal_hair_cell1.03558770
83MP0002229_neurodegeneration0.99355500
84MP0010630_abnormal_cardiac_muscle0.97874677
85MP0001346_abnormal_lacrimal_gland0.96283550
86MP0005369_muscle_phenotype0.96069291
87MP0005409_darkened_coat_color0.95089177
88MP0001984_abnormal_olfaction0.95066303
89MP0005535_abnormal_body_temperature0.94594713
90MP0000013_abnormal_adipose_tissue0.94371387
91MP0003283_abnormal_digestive_organ0.94249269
92MP0005167_abnormal_blood-brain_barrier0.93378286
93MP0010307_abnormal_tumor_latency0.93168200
94MP0009672_abnormal_birth_weight0.91224798
95MP0002081_perinatal_lethality0.90591051
96MP0005187_abnormal_penis_morphology0.90334091
97MP0003172_abnormal_lysosome_physiology0.87913903
98MP0001727_abnormal_embryo_implantation0.86285448
99MP0005551_abnormal_eye_electrophysiolog0.85983414
100MP0001348_abnormal_lacrimal_gland0.85898613
101MP0000750_abnormal_muscle_regeneration0.85166087
102MP0008260_abnormal_autophagy0.84152097
103MP0003111_abnormal_nucleus_morphology0.82913029
104MP0003077_abnormal_cell_cycle0.81293748
105MP0003075_altered_response_to0.80863697
106MP0005621_abnormal_cell_physiology0.80347763
107MP0004215_abnormal_myocardial_fiber0.79531830
108MP0010352_gastrointestinal_tract_polyps0.79357372
109MP0003984_embryonic_growth_retardation0.78301465
110MP0001943_abnormal_respiration0.77873370
111MP0002069_abnormal_eating/drinking_beha0.77115750
112MP0004085_abnormal_heartbeat0.76619039
113MP0002088_abnormal_embryonic_growth/wei0.76454394
114MP0004197_abnormal_fetal_growth/weight/0.76060650
115MP0005380_embryogenesis_phenotype0.75662070
116MP0001672_abnormal_embryogenesis/_devel0.75662070
117MP0004742_abnormal_vestibular_system0.74809714
118MP0003195_calcinosis0.74433628
119MP0009703_decreased_birth_body0.74259025
120MP0001730_embryonic_growth_arrest0.73894289
121MP0000920_abnormal_myelination0.73467279
122MP0004233_abnormal_muscle_weight0.71409330
123MP0008961_abnormal_basal_metabolism0.71188156
124MP0008874_decreased_physiological_sensi0.70164596
125MP0010386_abnormal_urinary_bladder0.70092606
126MP0004142_abnormal_muscle_tone0.68951387
127MP0003122_maternal_imprinting0.68310101
128MP0000747_muscle_weakness0.67932465
129MP0003705_abnormal_hypodermis_morpholog0.66265387
130MP0005171_absent_coat_pigmentation0.65219940
131MP0001188_hyperpigmentation0.63774897
132MP0001529_abnormal_vocalization0.62015737
133MP0005645_abnormal_hypothalamus_physiol0.61703465
134MP0005360_urolithiasis0.59686313
135MP0004484_altered_response_of0.58761492
136MP0010329_abnormal_lipoprotein_level0.58251692
137MP0000631_abnormal_neuroendocrine_gland0.57768441
138MP0003045_fibrosis0.56318047
139MP0003137_abnormal_impulse_conducting0.54035893
140MP0001905_abnormal_dopamine_level0.53346655
141MP0003252_abnormal_bile_duct0.53124747
142MP0004036_abnormal_muscle_relaxation0.53101234
143MP0003861_abnormal_nervous_system0.52335187
144MP0004510_myositis0.52230489

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.38252330
2Focal seizures (HP:0007359)4.77140288
3Myokymia (HP:0002411)4.34500297
4Visual hallucinations (HP:0002367)4.32633910
5Action tremor (HP:0002345)3.85075542
6Termporal pattern (HP:0011008)3.51249745
7Insidious onset (HP:0003587)3.51249745
8Muscle fiber inclusion bodies (HP:0100299)3.45217493
9Supranuclear gaze palsy (HP:0000605)3.44089596
10Epileptic encephalopathy (HP:0200134)3.43076041
11Generalized tonic-clonic seizures (HP:0002069)3.36208413
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.35320664
13Nemaline bodies (HP:0003798)3.34263678
14Ankle clonus (HP:0011448)3.33691736
15Absence seizures (HP:0002121)3.27992369
16Mutism (HP:0002300)3.23706961
17Excessive salivation (HP:0003781)3.20924039
18Drooling (HP:0002307)3.20924039
19Atonic seizures (HP:0010819)3.20696474
20Dialeptic seizures (HP:0011146)3.17783518
21Urinary bladder sphincter dysfunction (HP:0002839)3.17538063
22Postural instability (HP:0002172)3.15529076
23Exercise-induced myalgia (HP:0003738)3.15448961
24Impaired vibration sensation in the lower limbs (HP:0002166)3.12565292
25Progressive cerebellar ataxia (HP:0002073)3.12222869
26Febrile seizures (HP:0002373)3.08314830
27Cerebral inclusion bodies (HP:0100314)3.04516842
28Papillary thyroid carcinoma (HP:0002895)2.96317292
29Cortical dysplasia (HP:0002539)2.87213699
30Abnormality of the left ventricular outflow tract (HP:0011103)2.84071855
31Subaortic stenosis (HP:0001682)2.84071855
32Urinary urgency (HP:0000012)2.80793037
33Dysdiadochokinesis (HP:0002075)2.80762552
34Papilledema (HP:0001085)2.79559429
35Neurofibrillary tangles (HP:0002185)2.77946311
36Poor eye contact (HP:0000817)2.76680224
37Truncal ataxia (HP:0002078)2.72381087
38Impaired social interactions (HP:0000735)2.72112870
39Abnormal social behavior (HP:0012433)2.72112870
40Broad-based gait (HP:0002136)2.69187645
41Depression (HP:0000716)2.67059971
42Abnormality of the corticospinal tract (HP:0002492)2.66800951
43Abnormality of the lower motor neuron (HP:0002366)2.62520483
44Inappropriate behavior (HP:0000719)2.60875044
45Hyperventilation (HP:0002883)2.60669143
46Hyporeflexia of lower limbs (HP:0002600)2.60298332
47Gaze-evoked nystagmus (HP:0000640)2.57898346
48Heterotopia (HP:0002282)2.57656634
49Difficulty running (HP:0009046)2.55010625
50Spastic gait (HP:0002064)2.51126067
51Dysmetria (HP:0001310)2.47348899
52Type 1 muscle fiber predominance (HP:0003803)2.46774105
53Insomnia (HP:0100785)2.44038619
54Bradykinesia (HP:0002067)2.43973292
55Impaired smooth pursuit (HP:0007772)2.42869789
56Frequent falls (HP:0002359)2.42512467
57Bundle branch block (HP:0011710)2.41279041
58Resting tremor (HP:0002322)2.40698100
59Hemiparesis (HP:0001269)2.40061439
60Akinesia (HP:0002304)2.35958163
61Macroorchidism (HP:0000053)2.32443488
62Blue irides (HP:0000635)2.32262218
63Exercise-induced muscle cramps (HP:0003710)2.31395659
64Lower limb muscle weakness (HP:0007340)2.30672405
65Calcaneovalgus deformity (HP:0001848)2.30090000
66Agitation (HP:0000713)2.29448431
67Genetic anticipation (HP:0003743)2.27928233
68Fetal akinesia sequence (HP:0001989)2.27685066
69Status epilepticus (HP:0002133)2.27309011
70Truncal obesity (HP:0001956)2.24993733
71Intention tremor (HP:0002080)2.24591060
72Abnormality of ocular smooth pursuit (HP:0000617)2.23578393
73Impaired vibratory sensation (HP:0002495)2.23241664
74Centrally nucleated skeletal muscle fibers (HP:0003687)2.22867905
75Volvulus (HP:0002580)2.22664895
76Cubitus valgus (HP:0002967)2.22625378
77Dysmetric saccades (HP:0000641)2.22100297
78Diplopia (HP:0000651)2.20153512
79Abnormality of binocular vision (HP:0011514)2.20153512
80Hyperacusis (HP:0010780)2.19572280
81Amblyopia (HP:0000646)2.18655678
82Anxiety (HP:0000739)2.17327446
83Scanning speech (HP:0002168)2.17035368
84EMG: neuropathic changes (HP:0003445)2.16805131
85Progressive inability to walk (HP:0002505)2.15901898
86Overgrowth (HP:0001548)2.14016793
87Amyotrophic lateral sclerosis (HP:0007354)2.12774952
88Global brain atrophy (HP:0002283)2.12394443
89Torticollis (HP:0000473)2.11356248
90Vertebral arch anomaly (HP:0008438)2.11299634
91Sparse lateral eyebrow (HP:0005338)2.11180484
92Absent speech (HP:0001344)2.10792169
93Lower limb amyotrophy (HP:0007210)2.10010703
94Scapular winging (HP:0003691)2.09695848
95Epileptiform EEG discharges (HP:0011182)2.08895602
96Distal arthrogryposis (HP:0005684)2.08800830
97Clonus (HP:0002169)2.06788881
98EEG with generalized epileptiform discharges (HP:0011198)2.05942126
99Deep philtrum (HP:0002002)2.04745166
100Abnormality of salivation (HP:0100755)2.03965532
101EMG: myopathic abnormalities (HP:0003458)2.03704998
102Abnormal hair whorl (HP:0010721)2.03446296
103Turricephaly (HP:0000262)2.02707624
104Hemiplegia (HP:0002301)2.01332868
105Hypsarrhythmia (HP:0002521)2.00283084
106Disinhibition (HP:0000734)1.99687482
107Hepatoblastoma (HP:0002884)1.98939585
108Megalencephaly (HP:0001355)1.97813208
109Abnormal eating behavior (HP:0100738)1.97340039
110Generalized myoclonic seizures (HP:0002123)1.91984097
111Protruding tongue (HP:0010808)1.91494789
112Morphological abnormality of the pyramidal tract (HP:0002062)1.90937596
113Hammertoe (HP:0001765)1.88199535
114Aplasia involving bones of the upper limbs (HP:0009823)1.88146586
115Aplasia of the phalanges of the hand (HP:0009802)1.88146586
116Aplasia involving bones of the extremities (HP:0009825)1.88146586
117Abnormality of the musculature of the pelvis (HP:0001469)1.87256106
118Abnormality of the hip-girdle musculature (HP:0001445)1.87256106
119Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86879906
120Abnormality of the foot musculature (HP:0001436)1.86380800
121Gait ataxia (HP:0002066)1.85977581
122Cystic hygroma (HP:0000476)1.85806946
123Focal dystonia (HP:0004373)1.85011005
124Postural tremor (HP:0002174)1.84561704
125Sudden death (HP:0001699)1.83873261
126Menstrual irregularities (HP:0000858)1.83367547
127Abnormality of the calcaneus (HP:0008364)1.82885526
128Medulloblastoma (HP:0002885)1.82815625
129Neuronal loss in central nervous system (HP:0002529)1.82202366
130Foot dorsiflexor weakness (HP:0009027)1.81203618
131Deformed tarsal bones (HP:0008119)1.80756488
132Rimmed vacuoles (HP:0003805)1.79941526
133Lower limb asymmetry (HP:0100559)1.78541612
134Peripheral hypomyelination (HP:0007182)1.78297949
135Skin nodule (HP:0200036)1.77766743
136Pointed chin (HP:0000307)1.77764100
137Apathy (HP:0000741)1.77668954
138Generalized hypopigmentation of hair (HP:0011358)1.77649964
139Thyroid carcinoma (HP:0002890)1.77098278
140Increased nuchal translucency (HP:0010880)1.76999489
141Intellectual disability, profound (HP:0002187)1.76973058
142Open mouth (HP:0000194)1.75983982
143Subacute progressive viral hepatitis (HP:0006572)1.75702401
144Obsessive-compulsive behavior (HP:0000722)1.75647780
145Degeneration of the lateral corticospinal tracts (HP:0002314)1.75339620
146Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.75339620
147Spastic paraplegia (HP:0001258)1.75179691
148Pheochromocytoma (HP:0002666)1.74889793
149Limb dystonia (HP:0002451)1.74851641
150Pelvic girdle muscle weakness (HP:0003749)1.74395919
151Stereotypic behavior (HP:0000733)1.74281983
152Decreased motor nerve conduction velocity (HP:0003431)1.74262061
153Leiomyosarcoma (HP:0100243)1.74152317
154Uterine leiomyosarcoma (HP:0002891)1.74152317
155Abnormality of the calf musculature (HP:0001430)1.73317221
156Exotropia (HP:0000577)1.72953916
157Rigidity (HP:0002063)1.71774939
158Germ cell neoplasia (HP:0100728)1.70745350
159Increased connective tissue (HP:0009025)1.69938993
160Deep palmar crease (HP:0006191)1.69644771
161Astrocytoma (HP:0009592)1.68870183
162Abnormality of the astrocytes (HP:0100707)1.68870183

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.19536386
2NTRK34.00010305
3EPHA43.50228845
4MAP3K93.43275028
5MAP3K43.15705591
6OBSCN2.41944927
7MINK12.37760343
8DAPK22.32982079
9MAP2K72.25991080
10EEF2K2.24739745
11CDK122.22203625
12PAK62.21531085
13MAP2K42.10498884
14CAMKK11.95826922
15KSR21.92423885
16NTRK21.89356301
17RIPK41.85479088
18SCYL21.76654775
19NTRK11.69949678
20MAP3K21.66495467
21PLK21.64499700
22ICK1.57689936
23TTN1.55740691
24BRD41.55585529
25SIK21.54389004
26KSR11.50606073
27LATS21.47745373
28PRKD31.45998866
29CDK51.42956211
30PNCK1.42032821
31RET1.31791962
32PHKG11.30096241
33PHKG21.30096241
34CAMKK21.28053594
35TNIK1.18283479
36MAPK131.17380000
37BRAF1.15834911
38CAMK1G1.12294356
39CASK1.09024880
40PAK31.08594609
41NEK91.07491616
42RAF11.04021658
43PRKCG1.04002344
44TYRO31.00577120
45FGFR20.98162459
46CAMK40.97897077
47MAP3K60.97645886
48STK380.94910694
49BCR0.93744269
50SGK20.91490441
51CSNK1G20.91148520
52SGK30.90303225
53MTOR0.87973381
54PTK2B0.87505203
55SGK2230.87268861
56SGK4940.87268861
57CAMK2A0.87175723
58RIPK10.87003067
59PRKCH0.85024624
60ERBB30.84856273
61DAPK10.84398693
62GRK50.83871634
63STK110.83459889
64RPS6KB10.83430919
65SGK10.83359262
66FRK0.82850665
67FGR0.82273297
68PKN10.82223060
69ALK0.82117388
70CCNB10.80282284
71INSRR0.78010009
72AKT30.76908156
73PDGFRA0.76172992
74EPHA30.75362322
75FES0.74785227
76MAP3K120.74665132
77PDPK10.71869932
78CAMK1D0.71591537
79FER0.70447908
80UHMK10.70420516
81CDK140.68637839
82CDK150.66930808
83PDK10.66462740
84CDK180.65567336
85MAPK100.65029906
86WNK10.61535803
87BMPR20.61022049
88ERBB40.59790635
89EIF2AK30.59687106
90PRKCE0.59610679
91RPS6KA30.58828823
92DDR20.58590561
93LMTK20.58310610
94MAP3K50.57675185
95MARK20.57407415
96WNK30.56173890
97PINK10.55918304
98DYRK1A0.55725845
99FYN0.55332934
100PRKCZ0.51922983
101RPS6KA20.51831265
102DMPK0.51060616
103PDGFRB0.50052844
104PRKDC0.49820389
105CDK11A0.49716881
106CHEK10.49596067
107DYRK1B0.48883425
108CAMK2B0.48172458
109CDK60.48106136
110GSK3B0.47098625
111MAP3K130.46421970
112CDK20.46388479
113AKT20.45299656
114SMG10.43977650
115ATM0.43938451
116CDK10.43623531
117TRIB30.43150369
118MAPK40.42692290
119MAPK120.42263702
120ARAF0.41399199
121MAPK90.41363477
122CSNK1D0.41315677
123MAPK140.39759870
124CDC42BPA0.38964447
125PRKCB0.36793435
126MAP2K10.35999763
127MAPK80.35518753
128PRKAA10.35371484
129CAMK10.35082192
130PRPF4B0.34816618
131NEK10.34405285
132JAK10.33993573
133MAP3K10.33303451
134CSNK1E0.32620045

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.89562621
2Synaptic vesicle cycle_Homo sapiens_hsa047212.59919101
3Nitrogen metabolism_Homo sapiens_hsa009102.46585651
4GABAergic synapse_Homo sapiens_hsa047272.32589535
5Long-term potentiation_Homo sapiens_hsa047202.22459621
6Circadian entrainment_Homo sapiens_hsa047132.15085124
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.13771939
8Glutamatergic synapse_Homo sapiens_hsa047242.04130071
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99004747
10Morphine addiction_Homo sapiens_hsa050321.98526826
11Olfactory transduction_Homo sapiens_hsa047401.93708490
12Amphetamine addiction_Homo sapiens_hsa050311.93606394
13Dopaminergic synapse_Homo sapiens_hsa047281.84674335
14Insulin secretion_Homo sapiens_hsa049111.71455318
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69604745
16Salivary secretion_Homo sapiens_hsa049701.69044734
17Cholinergic synapse_Homo sapiens_hsa047251.66892297
18Type II diabetes mellitus_Homo sapiens_hsa049301.61909316
19Renin secretion_Homo sapiens_hsa049241.60892810
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46377383
21Colorectal cancer_Homo sapiens_hsa052101.46223481
22Gastric acid secretion_Homo sapiens_hsa049711.43034251
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42884885
24Oxytocin signaling pathway_Homo sapiens_hsa049211.42855683
25Long-term depression_Homo sapiens_hsa047301.42539721
26Cocaine addiction_Homo sapiens_hsa050301.40801085
27Chronic myeloid leukemia_Homo sapiens_hsa052201.35937961
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30863336
29Taste transduction_Homo sapiens_hsa047421.27696630
30Pancreatic cancer_Homo sapiens_hsa052121.27542952
31GnRH signaling pathway_Homo sapiens_hsa049121.25327248
32Serotonergic synapse_Homo sapiens_hsa047261.25229714
33Glioma_Homo sapiens_hsa052141.22689221
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20927706
35Estrogen signaling pathway_Homo sapiens_hsa049151.18974627
36B cell receptor signaling pathway_Homo sapiens_hsa046621.18919890
37Calcium signaling pathway_Homo sapiens_hsa040201.18335884
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16987716
39Gap junction_Homo sapiens_hsa045401.15579312
40Adherens junction_Homo sapiens_hsa045201.14272027
41Dorso-ventral axis formation_Homo sapiens_hsa043201.12803944
42Thyroid cancer_Homo sapiens_hsa052161.10330611
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09664908
44Circadian rhythm_Homo sapiens_hsa047101.08498510
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08257757
46Arginine biosynthesis_Homo sapiens_hsa002201.05692928
47Axon guidance_Homo sapiens_hsa043601.04716722
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02671561
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02105154
50cAMP signaling pathway_Homo sapiens_hsa040241.00606942
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00600442
52Bile secretion_Homo sapiens_hsa049760.98235163
53ErbB signaling pathway_Homo sapiens_hsa040120.97538998
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93558519
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92932357
56FoxO signaling pathway_Homo sapiens_hsa040680.92371219
57Prostate cancer_Homo sapiens_hsa052150.91790401
58MicroRNAs in cancer_Homo sapiens_hsa052060.90610056
59mRNA surveillance pathway_Homo sapiens_hsa030150.89485599
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88458650
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87245159
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86045267
63mTOR signaling pathway_Homo sapiens_hsa041500.84971404
64Collecting duct acid secretion_Homo sapiens_hsa049660.84758335
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.83186190
66Prion diseases_Homo sapiens_hsa050200.81760628
67Melanogenesis_Homo sapiens_hsa049160.80934598
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80150501
69Focal adhesion_Homo sapiens_hsa045100.77374153
70Thyroid hormone synthesis_Homo sapiens_hsa049180.74146586
71Dilated cardiomyopathy_Homo sapiens_hsa054140.73858149
72Glucagon signaling pathway_Homo sapiens_hsa049220.73222295
73Proteoglycans in cancer_Homo sapiens_hsa052050.72422200
74Acute myeloid leukemia_Homo sapiens_hsa052210.71768209
75Choline metabolism in cancer_Homo sapiens_hsa052310.70870882
76Butanoate metabolism_Homo sapiens_hsa006500.70760564
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.70205275
78Renal cell carcinoma_Homo sapiens_hsa052110.66229024
79Lysine degradation_Homo sapiens_hsa003100.65868950
80Cell cycle_Homo sapiens_hsa041100.65525462
81Non-homologous end-joining_Homo sapiens_hsa034500.65414124
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.63420680
83Hippo signaling pathway_Homo sapiens_hsa043900.62162176
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62135985
85Tight junction_Homo sapiens_hsa045300.62085956
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61330325
87Insulin signaling pathway_Homo sapiens_hsa049100.61136508
88Endometrial cancer_Homo sapiens_hsa052130.60015834
89Hepatitis B_Homo sapiens_hsa051610.59539333
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59308588
91Inositol phosphate metabolism_Homo sapiens_hsa005620.57516824
92Oocyte meiosis_Homo sapiens_hsa041140.57494515
93VEGF signaling pathway_Homo sapiens_hsa043700.56342778
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56144224
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55463070
96Melanoma_Homo sapiens_hsa052180.55386556
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.55187065
98MAPK signaling pathway_Homo sapiens_hsa040100.55179893
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54639722
100Alcoholism_Homo sapiens_hsa050340.54098480
101Bladder cancer_Homo sapiens_hsa052190.53673515
102Pancreatic secretion_Homo sapiens_hsa049720.53389870
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51544445
104Ras signaling pathway_Homo sapiens_hsa040140.51334506
105Fatty acid biosynthesis_Homo sapiens_hsa000610.51122250
106Vibrio cholerae infection_Homo sapiens_hsa051100.50585596
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49767083
108Rap1 signaling pathway_Homo sapiens_hsa040150.49688214
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.47603481
110* Endocytosis_Homo sapiens_hsa041440.47058636
111Non-small cell lung cancer_Homo sapiens_hsa052230.46726211
112Ovarian steroidogenesis_Homo sapiens_hsa049130.43376248
113Type I diabetes mellitus_Homo sapiens_hsa049400.41852567
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41349007
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.40347456
116AMPK signaling pathway_Homo sapiens_hsa041520.39278190
117Insulin resistance_Homo sapiens_hsa049310.39166230
118Cardiac muscle contraction_Homo sapiens_hsa042600.38284670
119Phototransduction_Homo sapiens_hsa047440.38213402
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37423883
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34717524
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33802302
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33656003
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.33643848
125Prolactin signaling pathway_Homo sapiens_hsa049170.32806825
126Complement and coagulation cascades_Homo sapiens_hsa046100.32152466
127Mineral absorption_Homo sapiens_hsa049780.31821404

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