RABEP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.55736825
2antigen processing and presentation of endogenous antigen (GO:0019883)5.15500922
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.10418941
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.10418941
5actin-myosin filament sliding (GO:0033275)4.63571138
6muscle filament sliding (GO:0030049)4.63571138
7regulation of gamma-delta T cell differentiation (GO:0045586)4.54799012
8regulation of gamma-delta T cell activation (GO:0046643)4.31670192
9regulation of skeletal muscle contraction (GO:0014819)4.27970355
10skeletal muscle contraction (GO:0003009)4.13660332
11ribosomal small subunit assembly (GO:0000028)3.96533579
12skeletal muscle adaptation (GO:0043501)3.94372972
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.85290383
14viral transcription (GO:0019083)3.82126404
15positive thymic T cell selection (GO:0045059)3.80161917
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.75566893
17negative regulation of cell killing (GO:0031342)3.75566893
18B cell receptor signaling pathway (GO:0050853)3.73745864
19cytidine metabolic process (GO:0046087)3.68395757
20cytidine catabolic process (GO:0006216)3.68395757
21cytidine deamination (GO:0009972)3.68395757
22translational termination (GO:0006415)3.61701664
23mannose metabolic process (GO:0006013)3.59221400
24pyrimidine ribonucleoside catabolic process (GO:0046133)3.53207928
25positive regulation of B cell differentiation (GO:0045579)3.49027072
26actin-mediated cell contraction (GO:0070252)3.48350140
27positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.47224973
28regulation of B cell differentiation (GO:0045577)3.46004169
29regulation of B cell receptor signaling pathway (GO:0050855)3.44726119
30DNA deamination (GO:0045006)3.41733753
31translational elongation (GO:0006414)3.36510250
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.33828486
33IMP metabolic process (GO:0046040)3.31285674
34negative regulation of erythrocyte differentiation (GO:0045647)3.30009820
35antigen processing and presentation via MHC class Ib (GO:0002475)3.27167962
36immunoglobulin mediated immune response (GO:0016064)3.24325890
37CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.19411321
38positive regulation of histone deacetylation (GO:0031065)3.16244274
39IMP biosynthetic process (GO:0006188)3.13501433
40regulation of antigen processing and presentation (GO:0002577)3.09919890
41regulation of interferon-beta biosynthetic process (GO:0045357)3.08747976
42ribosomal small subunit biogenesis (GO:0042274)3.06279415
43regulation of dendritic cell antigen processing and presentation (GO:0002604)3.04965183
44regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.98779123
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.98487985
46definitive hemopoiesis (GO:0060216)2.96019391
47positive regulation of defense response to virus by host (GO:0002230)2.95816726
48defense response to protozoan (GO:0042832)2.95170649
49B cell mediated immunity (GO:0019724)2.94702385
50response to protozoan (GO:0001562)2.93436719
51NIK/NF-kappaB signaling (GO:0038061)2.93428664
52GDP-mannose metabolic process (GO:0019673)2.92994470
53viral life cycle (GO:0019058)2.92117990
54purine nucleotide salvage (GO:0032261)2.91520987
55regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.89617801
56regulation of T-helper 1 cell differentiation (GO:0045625)2.89523836
57regulation of type I interferon-mediated signaling pathway (GO:0060338)2.88334267
58protein targeting to ER (GO:0045047)2.87770191
59cellular response to zinc ion (GO:0071294)2.87346166
60negative regulation of interleukin-12 production (GO:0032695)2.86456338
61translational initiation (GO:0006413)2.85211477
62positive regulation of antigen processing and presentation (GO:0002579)2.85184936
63cotranslational protein targeting to membrane (GO:0006613)2.84993446
64maturation of SSU-rRNA (GO:0030490)2.84862512
65response to peptidoglycan (GO:0032494)2.82773258
66cellular response to exogenous dsRNA (GO:0071360)2.82665946
67nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.82308990
68response to muramyl dipeptide (GO:0032495)2.82235948
69positive regulation of T cell mediated cytotoxicity (GO:0001916)2.81867861
70detection of bacterium (GO:0016045)2.78917496
71regulation of T cell mediated cytotoxicity (GO:0001914)2.78676872
72thymic T cell selection (GO:0045061)2.76922244
73Arp2/3 complex-mediated actin nucleation (GO:0034314)2.74602874
74macrophage activation involved in immune response (GO:0002281)2.74354265
75interferon-gamma secretion (GO:0072643)2.74162595
76positive regulation of protein deacetylation (GO:0090312)2.73937470
77establishment of protein localization to endoplasmic reticulum (GO:0072599)2.71623411
78natural killer cell differentiation (GO:0001779)2.69933036
79protein localization to endoplasmic reticulum (GO:0070972)2.68506166
80striated muscle atrophy (GO:0014891)2.68029834
81negative thymic T cell selection (GO:0045060)2.67787198
82formation of translation preinitiation complex (GO:0001731)2.66531400
83leukocyte aggregation (GO:0070486)2.64983213
84T cell migration (GO:0072678)2.64960308
85actin filament-based movement (GO:0030048)2.64852150
86tumor necrosis factor-mediated signaling pathway (GO:0033209)2.64651035
87response to interleukin-15 (GO:0070672)2.64226462
88cellular protein complex disassembly (GO:0043624)2.64098725
89modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.63434382
90positive regulation by organism of defense response of other organism involved in symbiotic interact2.63434382
91modulation by symbiont of host immune response (GO:0052553)2.63434382
92positive regulation by symbiont of host defense response (GO:0052509)2.63434382
93modulation by symbiont of host defense response (GO:0052031)2.63434382
94modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.63434382
95response to type I interferon (GO:0034340)2.62602202
96negative regulation of innate immune response (GO:0045824)2.62550626
97detection of other organism (GO:0098543)2.61435927
98cellular response to interleukin-15 (GO:0071350)2.61305442
99regulation of defense response to virus by host (GO:0050691)2.60495235
100type I interferon signaling pathway (GO:0060337)2.59398663
101cellular response to type I interferon (GO:0071357)2.59398663
102mature B cell differentiation involved in immune response (GO:0002313)2.59334925
103positive regulation of type 2 immune response (GO:0002830)2.58235361
104skeletal muscle tissue regeneration (GO:0043403)2.58050306
105positive regulation of Cdc42 GTPase activity (GO:0043089)2.57299496
106positive regulation of natural killer cell differentiation (GO:0032825)2.56837776
107fat-soluble vitamin biosynthetic process (GO:0042362)2.55625080
108positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.55248223
109muscle atrophy (GO:0014889)2.54786025
110neutrophil activation involved in immune response (GO:0002283)2.53784339
111regulation of interleukin-12 biosynthetic process (GO:0045075)2.52517674
112lymph node development (GO:0048535)2.50362678
113lipopolysaccharide-mediated signaling pathway (GO:0031663)2.49894148
114mature B cell differentiation (GO:0002335)2.49496721
115actin nucleation (GO:0045010)2.48723357
116negative T cell selection (GO:0043383)2.48691373
117regulation of mast cell degranulation (GO:0043304)2.47502791
118regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.46716062
119purine-containing compound salvage (GO:0043101)2.45415818
120T cell costimulation (GO:0031295)2.45245572
121positive regulation of chemokine secretion (GO:0090197)2.44824635
122regulation of T-helper 2 cell differentiation (GO:0045628)2.44704466
123negative regulation of alpha-beta T cell activation (GO:0046636)2.44632065
124negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.44374455
125regulation of T cell tolerance induction (GO:0002664)2.44187196
126skeletal muscle fiber development (GO:0048741)2.43506790
127regulation of natural killer cell mediated immunity (GO:0002715)2.43402329
128regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.43402329
129valine metabolic process (GO:0006573)2.43354466
130granulocyte activation (GO:0036230)2.42810242
131regulation of alpha-beta T cell proliferation (GO:0046640)2.41961993
132telomere maintenance via semi-conservative replication (GO:0032201)2.41547146
133tolerance induction (GO:0002507)2.41423246
134N-acetylneuraminate metabolic process (GO:0006054)2.41346728
135lymphocyte costimulation (GO:0031294)2.40673402
136negative regulation of granulocyte differentiation (GO:0030853)2.39895056
137positive regulation of calcium-mediated signaling (GO:0050850)2.38981437
138negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.38946671
139T cell selection (GO:0045058)2.38261920
140Peyers patch development (GO:0048541)2.38080582
141mucosal-associated lymphoid tissue development (GO:0048537)2.38080582
142T cell homeostasis (GO:0043029)2.37894902
143negative regulation of necroptotic process (GO:0060546)2.37473976
144protein complex disassembly (GO:0043241)2.36540753
145interferon-gamma-mediated signaling pathway (GO:0060333)2.36365315
146regulation of necroptotic process (GO:0060544)2.36283518
147positive T cell selection (GO:0043368)2.31567257
148regulation of response to interferon-gamma (GO:0060330)2.31097043
149lymphocyte homeostasis (GO:0002260)2.30375779
150germinal center formation (GO:0002467)2.29751193
151regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.28833602
152antigen receptor-mediated signaling pathway (GO:0050851)2.27952035
153morphogenesis of an endothelium (GO:0003159)2.27213858
154endothelial tube morphogenesis (GO:0061154)2.27213858
1553-UTR-mediated mRNA stabilization (GO:0070935)2.25813845
156negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.23533656
157DNA strand elongation involved in DNA replication (GO:0006271)2.22148599
158positive regulation of interferon-alpha production (GO:0032727)2.22089606
159sequestering of actin monomers (GO:0042989)2.21743940

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.71774204
2E2F7_22180533_ChIP-Seq_HELA_Human3.17938058
3MYC_22102868_ChIP-Seq_BL_Human2.96523351
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72668879
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.65632213
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.47933341
7VDR_21846776_ChIP-Seq_THP-1_Human2.47567604
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.46205256
9* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.33975317
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24734957
11* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.21935914
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.21095728
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.09272081
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.04661856
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.04446602
16MAF_26560356_Chip-Seq_TH1_Human2.03952153
17* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.01107781
18FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.00573738
19SCL_19346495_ChIP-Seq_HPC-7_Human1.94317038
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91275049
21* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.90771227
22CIITA_25753668_ChIP-Seq_RAJI_Human1.89448106
23RACK7_27058665_Chip-Seq_MCF-7_Human1.88860067
24P68_20966046_ChIP-Seq_HELA_Human1.83087648
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80233673
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.80217306
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.77644357
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.77571753
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.76180535
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.76115975
31UTX_26944678_Chip-Seq_JUKART_Human1.74942992
32SPI1_23547873_ChIP-Seq_NB4_Human1.73332629
33* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73130626
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66941581
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66919743
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.62766714
37* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62553519
38* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62365562
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.61659909
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.61495100
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59995070
42MYB_26560356_Chip-Seq_TH1_Human1.59604130
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.58643380
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.57741217
45MAF_26560356_Chip-Seq_TH2_Human1.52779852
46MYB_26560356_Chip-Seq_TH2_Human1.52083281
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51544762
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.51510126
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50292901
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50280231
51TCF7_22412390_ChIP-Seq_EML_Mouse1.49919312
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48413228
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.47819259
54XRN2_22483619_ChIP-Seq_HELA_Human1.47106311
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45925533
56VDR_24763502_ChIP-Seq_THP-1_Human1.45239046
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44767145
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.44308639
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.44139265
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40199147
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39725091
62SMC4_20622854_ChIP-Seq_HELA_Human1.39166278
63GATA1_22025678_ChIP-Seq_K562_Human1.39138546
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39106754
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38576347
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.37113763
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36373823
68* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35958169
69MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35729580
70SPI1_23127762_ChIP-Seq_K562_Human1.35564069
71VDR_23849224_ChIP-Seq_CD4+_Human1.34831670
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32883519
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31738929
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30220921
75FOXP3_21729870_ChIP-Seq_TREG_Human1.29719077
76ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29605433
77NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29414261
78SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.29323786
79TP63_17297297_ChIP-ChIP_HaCaT_Human1.28840472
80E2F1_20622854_ChIP-Seq_HELA_Human1.28184448
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26150352
82GATA1_19941827_ChIP-Seq_MEL_Mouse1.25984406
83FOXM1_23109430_ChIP-Seq_U2OS_Human1.25613996
84PHF8_20622854_ChIP-Seq_HELA_Human1.23981304
85ESR1_21235772_ChIP-Seq_MCF-7_Human1.22849863
86RARB_24833708_ChIP-Seq_LIVER_Mouse1.22222740
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21777152
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21631529
89* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21332107
90GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21120589
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20770441
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20357869
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19732981
94* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19587326
95* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19578692
96FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19082262
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18259843
98BCL6_27268052_Chip-Seq_Bcells_Human1.18144983
99PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17237953
100SRF_21415370_ChIP-Seq_HL-1_Mouse1.16441738
101* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16408242
102TP53_22127205_ChIP-Seq_IMR90_Human1.16068085
103* CREB1_26743006_Chip-Seq_LNCaP_Human1.15967022
104SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15325709
105* RUNX1_27514584_Chip-Seq_MCF-7_Human1.14785305
106CREB1_15753290_ChIP-ChIP_HEK293T_Human1.14753085
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14677739
108P63_26484246_Chip-Seq_KERATINOCYTES_Human1.14170380
109NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13326959
110NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13205123
111CTCF_21964334_ChIP-Seq_BJAB-B_Human1.12934836
112CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12618859
113DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11898863
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11708773
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11019177
116PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10822303
117CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10780282
118KDM2B_26808549_Chip-Seq_DND41_Human1.10704105
119KDM2B_26808549_Chip-Seq_JURKAT_Human1.10363358
120HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10289404
121PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09299844
122TP63_22573176_ChIP-Seq_HFKS_Human1.08879746
123PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08160102
124CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08041258
125P300_27268052_Chip-Seq_Bcells_Human1.07468684
126LXR_22292898_ChIP-Seq_THP-1_Human1.06981630
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06823540
128RUNX_20019798_ChIP-Seq_JUKART_Human1.06758804
129KDM2B_26808549_Chip-Seq_K562_Human1.06537494
130E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06319433
131CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05933473
132TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05661785
133GABP_19822575_ChIP-Seq_HepG2_Human1.05649134
134NCOR1_26117541_ChIP-Seq_K562_Human1.05184193
135DCP1A_22483619_ChIP-Seq_HELA_Human1.04460796
136CTCF_26484167_Chip-Seq_Bcells_Mouse1.03647978
137* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01047700
138ELF1_20517297_ChIP-Seq_JURKAT_Human1.00200974
139RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99449184
140* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98508389
141* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97251404
142BCOR_27268052_Chip-Seq_Bcells_Human0.97157234
143STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96858031

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.32376314
2MP0000685_abnormal_immune_system3.15587710
3MP0004145_abnormal_muscle_electrophysio2.82072552
4MP0001800_abnormal_humoral_immune2.69716167
5MP0003763_abnormal_thymus_physiology2.69539782
6MP0005387_immune_system_phenotype2.57802244
7MP0001790_abnormal_immune_system2.57802244
8MP0003172_abnormal_lysosome_physiology2.56682014
9MP0000749_muscle_degeneration2.43596670
10MP0002396_abnormal_hematopoietic_system2.37745862
11MP0002138_abnormal_hepatobiliary_system2.36331738
12MP0005671_abnormal_response_to2.28338464
13MP0002452_abnormal_antigen_presenting2.17424924
14MP0001873_stomach_inflammation2.13747471
15MP0003436_decreased_susceptibility_to2.12653934
16MP0005000_abnormal_immune_tolerance2.08878634
17MP0002723_abnormal_immune_serum2.05097840
18MP0009785_altered_susceptibility_to2.02528083
19MP0002420_abnormal_adaptive_immunity2.01080329
20MP0002166_altered_tumor_susceptibility1.99912126
21MP0002398_abnormal_bone_marrow1.98378350
22MP0001819_abnormal_immune_cell1.97082984
23MP0005310_abnormal_salivary_gland1.88411089
24MP0002106_abnormal_muscle_physiology1.84260339
25MP0000747_muscle_weakness1.82199898
26MP0000689_abnormal_spleen_morphology1.76476875
27MP0000716_abnormal_immune_system1.74577690
28MP0005451_abnormal_body_composition1.74088639
29MP0009333_abnormal_splenocyte_physiolog1.71958606
30MP0005025_abnormal_response_to1.71251133
31MP0004381_abnormal_hair_follicle1.68621446
32MP0003646_muscle_fatigue1.67167961
33MP0002722_abnormal_immune_system1.67061948
34MP0000751_myopathy1.64088463
35MP0008260_abnormal_autophagy1.63014679
36MP0000759_abnormal_skeletal_muscle1.61067127
37MP0000733_abnormal_muscle_development1.60320818
38MP0002429_abnormal_blood_cell1.59751819
39MP0001853_heart_inflammation1.59366506
40MP0010155_abnormal_intestine_physiology1.57677459
41MP0003183_abnormal_peptide_metabolism1.56966960
42MP0004808_abnormal_hematopoietic_stem1.56095006
43MP0003693_abnormal_embryo_hatching1.52339333
44MP0002148_abnormal_hypersensitivity_rea1.48067302
45MP0002405_respiratory_system_inflammati1.45028662
46MP0005369_muscle_phenotype1.41677833
47MP0004947_skin_inflammation1.41392556
48MP0002419_abnormal_innate_immunity1.40263481
49MP0002269_muscular_atrophy1.39718817
50MP0002006_tumorigenesis1.38527069
51MP0000703_abnormal_thymus_morphology1.35037645
52MP0000750_abnormal_muscle_regeneration1.34428429
53MP0003279_aneurysm1.34075732
54MP0008007_abnormal_cellular_replicative1.33638428
55MP0004087_abnormal_muscle_fiber1.31295393
56MP0005464_abnormal_platelet_physiology1.29470723
57MP0005397_hematopoietic_system_phenotyp1.28664078
58MP0001545_abnormal_hematopoietic_system1.28664078
59MP0003806_abnormal_nucleotide_metabolis1.27796640
60MP0004510_myositis1.27620815
61MP0003724_increased_susceptibility_to1.27432773
62MP0000465_gastrointestinal_hemorrhage1.26256157
63MP0004036_abnormal_muscle_relaxation1.22601043
64MP0002933_joint_inflammation1.21597478
65MP0009278_abnormal_bone_marrow1.20639678
66MP0000015_abnormal_ear_pigmentation1.19748971
67MP0001845_abnormal_inflammatory_respons1.18613322
68MP0008058_abnormal_DNA_repair1.17590311
69MP0003077_abnormal_cell_cycle1.16638459
70MP0010094_abnormal_chromosome_stability1.15688808
71MP0002998_abnormal_bone_remodeling1.14320479
72MP0000490_abnormal_crypts_of1.13902674
73MP0002019_abnormal_tumor_incidence1.12668267
74MP0003705_abnormal_hypodermis_morpholog1.11786565
75MP0005360_urolithiasis1.11599214
76MP0001958_emphysema1.11041206
77MP0009764_decreased_sensitivity_to1.10355855
78MP0009384_cardiac_valve_regurgitation1.09712585
79MP0003300_gastrointestinal_ulcer1.08722677
80MP0003866_abnormal_defecation1.08622847
81MP0001663_abnormal_digestive_system1.05314133
82MP0003111_abnormal_nucleus_morphology1.03891908
83MP0004130_abnormal_muscle_cell1.02843416
84MP0002653_abnormal_ependyma_morphology1.01868212
85MP0004858_abnormal_nervous_system1.01462072
86MP0008469_abnormal_protein_level1.01291148
87MP0001849_ear_inflammation0.97655198
88MP0008057_abnormal_DNA_replication0.97530239
89MP0005083_abnormal_biliary_tract0.94968944
90MP0000678_abnormal_parathyroid_gland0.92642489
91MP0005390_skeleton_phenotype0.92393161
92MP0006036_abnormal_mitochondrial_physio0.92197608
93MP0004957_abnormal_blastocyst_morpholog0.91488632
94MP0003045_fibrosis0.90909082
95MP0001348_abnormal_lacrimal_gland0.90734522
96MP0005075_abnormal_melanosome_morpholog0.90288157
97MP0004264_abnormal_extraembryonic_tissu0.89973252
98MP0000858_altered_metastatic_potential0.89674488
99MP0000343_altered_response_to0.88926673
100MP0003303_peritoneal_inflammation0.87662080
101MP0002132_abnormal_respiratory_system0.87169806
102MP0005167_abnormal_blood-brain_barrier0.86910193
103MP0005076_abnormal_cell_differentiation0.85248561
104MP0005023_abnormal_wound_healing0.85002012
105MP0000249_abnormal_blood_vessel0.84949438
106MP0010630_abnormal_cardiac_muscle0.84183249
107MP0003191_abnormal_cellular_cholesterol0.83735587
108MP0002136_abnormal_kidney_physiology0.82379829
109MP0000604_amyloidosis0.81870689
110MP0001533_abnormal_skeleton_physiology0.81678582
111MP0003448_altered_tumor_morphology0.81608286
112MP0009840_abnormal_foam_cell0.81223714
113MP0005058_abnormal_lysosome_morphology0.81090662
114MP0001765_abnormal_ion_homeostasis0.80942114
115MP0001986_abnormal_taste_sensitivity0.80488545
116MP0003075_altered_response_to0.80361418
117MP0005501_abnormal_skin_physiology0.80263378
118MP0010352_gastrointestinal_tract_polyps0.79558488
119MP0006082_CNS_inflammation0.78329077
120MP0009643_abnormal_urine_homeostasis0.77697840
121MP0000313_abnormal_cell_death0.77426436
122MP0003566_abnormal_cell_adhesion0.75956808
123MP0002796_impaired_skin_barrier0.73677022
124MP0003567_abnormal_fetal_cardiomyocyte0.73307521
125MP0010234_abnormal_vibrissa_follicle0.73111380
126MP0000767_abnormal_smooth_muscle0.72717177
127MP0003795_abnormal_bone_structure0.72013057
128MP0005166_decreased_susceptibility_to0.70519895
129MP0002332_abnormal_exercise_endurance0.70213104
130MP0003786_premature_aging0.69128427
131MP0003091_abnormal_cell_migration0.68213255
132MP0005381_digestive/alimentary_phenotyp0.68193471
133MP0002254_reproductive_system_inflammat0.67975243
134MP0000350_abnormal_cell_proliferation0.67258684
135MP0003453_abnormal_keratinocyte_physiol0.66665448
136MP0001243_abnormal_dermal_layer0.66485348
137MP0005620_abnormal_muscle_contractility0.65895573
138MP0003828_pulmonary_edema0.65843684
139MP0001879_abnormal_lymphatic_vessel0.64928297
140MP0002234_abnormal_pharynx_morphology0.64893858
141MP0002060_abnormal_skin_morphology0.63364526
142MP0001542_abnormal_bone_strength0.61916390

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.77900343
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.52516917
3Nemaline bodies (HP:0003798)6.44131676
4Distal arthrogryposis (HP:0005684)5.53632315
5Ulnar deviation of the wrist (HP:0003049)5.43200776
6Type 1 muscle fiber predominance (HP:0003803)5.26464381
7Myopathic facies (HP:0002058)5.09004316
8Round ear (HP:0100830)4.70124265
9Exercise-induced myalgia (HP:0003738)4.48270045
10Calcaneovalgus deformity (HP:0001848)4.41506402
11Deformed tarsal bones (HP:0008119)4.08962339
12Exercise-induced muscle cramps (HP:0003710)4.07697939
13Agammaglobulinemia (HP:0004432)3.86116550
14Dysostosis multiplex (HP:0000943)3.58318045
15J-shaped sella turcica (HP:0002680)3.53521402
16Mediastinal lymphadenopathy (HP:0100721)3.48935037
17Abnormality of liposaccharide metabolism (HP:0010968)3.38820143
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.38820143
19Abnormality of glycolipid metabolism (HP:0010969)3.38820143
20Abnormality of macrophages (HP:0004311)3.23432455
21Absent phalangeal crease (HP:0006109)3.21701211
22Recurrent bronchitis (HP:0002837)3.15222168
23Abnormality of polysaccharide metabolism (HP:0011012)3.14818262
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.14818262
25Abnormality of mucopolysaccharide metabolism (HP:0011020)3.14818262
26Chronic otitis media (HP:0000389)3.11111412
27Muscle hypertrophy of the lower extremities (HP:0008968)3.10774425
28Abnormality of the calcaneus (HP:0008364)3.04975569
29Muscle fiber splitting (HP:0003555)3.04315339
30Panhypogammaglobulinemia (HP:0003139)3.03329527
31Gastrointestinal stroma tumor (HP:0100723)3.01313944
32Thin bony cortex (HP:0002753)3.00333170
33Mucopolysacchariduria (HP:0008155)2.99787992
34Urinary glycosaminoglycan excretion (HP:0003541)2.99787992
35Increased neuronal autofluorescent lipopigment (HP:0002074)2.98300304
36Increased connective tissue (HP:0009025)2.95738922
37Increased cerebral lipofuscin (HP:0011813)2.95667557
38IgM deficiency (HP:0002850)2.93291823
39Colitis (HP:0002583)2.87330290
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.86696805
41Rhabdomyolysis (HP:0003201)2.82656615
42Petechiae (HP:0000967)2.80614659
43Malignant hyperthermia (HP:0002047)2.75229265
44Abnormality of T cell physiology (HP:0011840)2.74628617
45Obstructive lung disease (HP:0006536)2.74454149
46Chronic obstructive pulmonary disease (HP:0006510)2.74454149
47Recurrent viral infections (HP:0004429)2.73894662
48Frequent falls (HP:0002359)2.72080387
49Myoglobinuria (HP:0002913)2.70529148
50Orchitis (HP:0100796)2.70522851
51Difficulty running (HP:0009046)2.69675026
52Progressive muscle weakness (HP:0003323)2.68322549
53Abnormal finger flexion creases (HP:0006143)2.67545706
54Cellulitis (HP:0100658)2.66440741
55Stomatitis (HP:0010280)2.65664303
56Vacuolated lymphocytes (HP:0001922)2.65643202
57Calf muscle hypertrophy (HP:0008981)2.65384341
58Pulmonary infiltrates (HP:0002113)2.65249300
59Abnormality of skeletal muscle fiber size (HP:0012084)2.64125409
60Muscle stiffness (HP:0003552)2.54644500
61EMG: myopathic abnormalities (HP:0003458)2.53108737
62Recurrent skin infections (HP:0001581)2.51988782
63Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.49404022
64Muscle fiber atrophy (HP:0100295)2.48753976
65Neck muscle weakness (HP:0000467)2.48718155
66Inflammation of the large intestine (HP:0002037)2.46999437
67Lymphopenia (HP:0001888)2.45345941
68Joint stiffness (HP:0001387)2.43094352
69Type 2 muscle fiber atrophy (HP:0003554)2.42322832
70Hemoptysis (HP:0002105)2.42132980
71Abnormality of cells of the lymphoid lineage (HP:0012140)2.42050487
72Hyporeflexia of lower limbs (HP:0002600)2.41962998
73Gastrointestinal inflammation (HP:0004386)2.40537667
74Recurrent fungal infections (HP:0002841)2.38913756
75Optic neuritis (HP:0100653)2.37149821
76Retrobulbar optic neuritis (HP:0100654)2.37149821
77T lymphocytopenia (HP:0005403)2.35257037
78Increased IgE level (HP:0003212)2.34749806
79Malnutrition (HP:0004395)2.34214551
80Gastrointestinal infarctions (HP:0005244)2.34209854
81Difficulty climbing stairs (HP:0003551)2.33629327
82Autoimmune thrombocytopenia (HP:0001973)2.31789513
83Slender build (HP:0001533)2.31060339
84Recurrent abscess formation (HP:0002722)2.30152484
85Thrombocytosis (HP:0001894)2.29228706
86Abnormality of the neuromuscular junction (HP:0003398)2.28202387
87Fatigable weakness (HP:0003473)2.28202387
88Chronic diarrhea (HP:0002028)2.27787483
89Hemorrhage of the eye (HP:0011885)2.26222846
90Encephalitis (HP:0002383)2.25547417
91Abnormality of the left ventricular outflow tract (HP:0011103)2.24959279
92Subaortic stenosis (HP:0001682)2.24959279
93Abnormality of T cells (HP:0002843)2.24517913
94Abnormality of T cell number (HP:0011839)2.24059581
95Pustule (HP:0200039)2.23081263
96Elevated erythrocyte sedimentation rate (HP:0003565)2.22289973
97Emphysema (HP:0002097)2.22160674
98Weak cry (HP:0001612)2.21188816
99Areflexia of lower limbs (HP:0002522)2.20543298
100Facial diplegia (HP:0001349)2.19675411
101Nasal polyposis (HP:0100582)2.17179614
102Meningitis (HP:0001287)2.17014202
103Mesangial abnormality (HP:0001966)2.16896341
104Asymmetric septal hypertrophy (HP:0001670)2.16895947
105Cervical subluxation (HP:0003308)2.16737873
106Verrucae (HP:0200043)2.09813450
107Papilloma (HP:0012740)2.09813450
108Increased serum ferritin (HP:0003281)2.09667714
109Hematochezia (HP:0002573)2.09434709
110Prolonged bleeding time (HP:0003010)2.09407082
111Chest pain (HP:0100749)2.09324963
112Systemic lupus erythematosus (HP:0002725)2.07884382
113Abnormality of the nasal mucosa (HP:0000433)2.07755116
114Gingivitis (HP:0000230)2.06913931
115Recurrent bacterial skin infections (HP:0005406)2.06348867
116Chronic mucocutaneous candidiasis (HP:0002728)2.05293505
117Recurrent cutaneous fungal infections (HP:0011370)2.05293505
118Centrally nucleated skeletal muscle fibers (HP:0003687)2.04793498
119Eczematoid dermatitis (HP:0000976)2.03535938
120Myositis (HP:0100614)2.02727866
121Loss of speech (HP:0002371)2.01420936
122Spontaneous hematomas (HP:0007420)1.98174564
123Hypergammaglobulinemia (HP:0010702)1.96965646
124Reticulocytopenia (HP:0001896)1.95124614
125Increased IgM level (HP:0003496)1.93686994
126Vasculitis (HP:0002633)1.92102301
127Stridor (HP:0010307)1.91198243
128Distal lower limb muscle weakness (HP:0009053)1.90872537
129Granulocytopenia (HP:0001913)1.90626216
130Myotonia (HP:0002486)1.89912293
131Abnormality of B cell number (HP:0010975)1.89467138
132Restrictive lung disease (HP:0002091)1.89280503
133Microretrognathia (HP:0000308)1.87782231
134Pelvic girdle muscle weakness (HP:0003749)1.87545946
135Reduced subcutaneous adipose tissue (HP:0003758)1.86377925
136Rimmed vacuoles (HP:0003805)1.84198984
137Generalized muscle weakness (HP:0003324)1.84192413
138Bulbar palsy (HP:0001283)1.83892994
139Abnormality of the pleura (HP:0002103)1.83874639
140Sepsis (HP:0100806)1.83595387
141Recurrent sinusitis (HP:0011108)1.82597884
142Prolonged neonatal jaundice (HP:0006579)1.82384550
143Broad face (HP:0000283)1.81799821
144IgG deficiency (HP:0004315)1.81376159
145B lymphocytopenia (HP:0010976)1.81055635
146Increased variability in muscle fiber diameter (HP:0003557)1.80150416
147Abnormality of iron homeostasis (HP:0011031)1.78650609
148Abnormality of cells of the erythroid lineage (HP:0012130)1.78628958
149Short palpebral fissure (HP:0012745)1.78162726
150Recurrent gram-negative bacterial infections (HP:0005420)1.77172313
151Lymphangioma (HP:0100764)1.76850872
152Hypertensive crisis (HP:0100735)1.76540680
153Bronchitis (HP:0012387)1.75704717
154Easy fatigability (HP:0003388)1.75509905
155Thoracic kyphosis (HP:0002942)1.73735368
156Recurrent lower respiratory tract infections (HP:0002783)1.73685598
157Arthralgia (HP:0002829)1.73429549
158Abnormal number of erythroid precursors (HP:0012131)1.72227962
159Autoimmune hemolytic anemia (HP:0001890)1.71932307
160Epistaxis (HP:0000421)1.71689861
161Deformed sella turcica (HP:0002681)1.71682911
162Osteomyelitis (HP:0002754)1.71366125

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.79603482
2MAP4K14.07882800
3TTN3.07477251
4OBSCN2.92530880
5ERN12.64479988
6MAP2K32.43341688
7TYK22.29182451
8PIK3CG2.24073903
9TEC2.04093135
10TNK22.01363077
11JAK31.99977841
12RIPK41.96584200
13NME21.93653791
14MAP3K101.91303038
15KIT1.87737438
16STK101.87038154
17IRAK31.84689582
18BTK1.75611889
19EEF2K1.74692933
20TRIB31.73707735
21BLK1.71999561
22TAOK31.67241522
23TBK11.60259277
24SMG11.56417790
25ZAP701.55388080
26KDR1.49315468
27TAOK11.44829744
28IKBKE1.43523275
29CSF1R1.42671191
30LRRK21.38237738
31FLT31.37393708
32FES1.34822812
33CDC42BPA1.29969626
34PRPF4B1.28898998
35MAP2K21.25129359
36PHKG11.22224000
37PHKG21.22224000
38SYK1.19759422
39MAP3K71.17919793
40NME11.17780021
41TGFBR21.16883354
42MAP2K61.16850252
43BCKDK1.16409305
44GRK61.16132837
45FGFR41.16039194
46TXK1.15626232
47IRAK41.12812909
48SIK21.11535346
49TLK11.07770771
50NEK91.05698312
51JAK11.03960585
52PKN21.03497365
53MARK31.02039041
54NEK21.01579761
55PIM21.01289202
56TGFBR11.01087615
57MAP3K141.00970474
58IKBKB1.00174704
59MAP3K110.99306498
60DYRK30.98557435
61SIK30.96812461
62TESK10.96300513
63RPS6KB20.96062402
64ACVR1B0.94740838
65PIM10.94494444
66MAPKAPK30.94404709
67MAPK110.94096629
68RPS6KA40.92938357
69MAPK120.92556762
70RPS6KA20.91667092
71HIPK20.91088583
72GRK10.89557109
73TAOK20.87028151
74MAP3K30.86851855
75ITK0.85911734
76MARK20.83664644
77RPS6KC10.82786790
78RPS6KL10.82786790
79MAPK150.81787143
80CAMK1D0.81451924
81EPHB10.80654673
82MAP3K130.77823091
83LCK0.76809761
84RPS6KA60.76201603
85RIPK10.74386275
86STK160.73175383
87NLK0.73122814
88MAP3K10.71936683
89HCK0.71290332
90LYN0.70566343
91BUB10.70235539
92PDPK10.69577699
93MATK0.69270861
94BMX0.68642521
95CSK0.68611965
96TSSK60.66036803
97CDK40.65003479
98EIF2AK30.62589168
99PRKCQ0.62323244
100IRAK10.61607700
101PDK10.60853575
102TRPM70.60704458
103SRPK10.60192051
104GRK70.58551244
105MAPK70.58297138
106MUSK0.55462561
107MAPKAPK20.52106082
108DYRK1B0.50957875
109IRAK20.50726952
110MAP3K80.49771984
111PRKG20.49633691
112CHUK0.48388717
113MAP3K60.47233236
114PRKD10.45735638
115CDK70.45568488
116SIK10.45197031
117PAK40.44699223
118ADRBK20.44617940
119PRKD30.41925221
120PTK60.41466908
121PASK0.41446102
122TESK20.40280466
123PIK3CA0.39864550
124MAPK40.38956055
125ICK0.37515735
126CAMKK10.37179969
127PRKD20.35915916
128CAMK1G0.35828921
129PRKCI0.34819349
130WEE10.34627786
131CLK10.34404719
132ILK0.29327030
133JAK20.28331937
134PINK10.27799788
135EPHA20.26945331
136PRKAA20.25799643

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.02191990
2Ribosome_Homo sapiens_hsa030102.99360522
3DNA replication_Homo sapiens_hsa030302.78057364
4Autoimmune thyroid disease_Homo sapiens_hsa053202.75696407
5B cell receptor signaling pathway_Homo sapiens_hsa046622.73470947
6Base excision repair_Homo sapiens_hsa034102.67545701
7Antigen processing and presentation_Homo sapiens_hsa046122.35057230
8Asthma_Homo sapiens_hsa053102.24856572
9Mismatch repair_Homo sapiens_hsa034302.10706257
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09245790
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.08023735
12Type I diabetes mellitus_Homo sapiens_hsa049402.01511806
13Staphylococcus aureus infection_Homo sapiens_hsa051501.93855392
14Hematopoietic cell lineage_Homo sapiens_hsa046401.82703737
15Leishmaniasis_Homo sapiens_hsa051401.82657204
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.80258375
17Measles_Homo sapiens_hsa051621.79281874
18Lysosome_Homo sapiens_hsa041421.72613915
19Herpes simplex infection_Homo sapiens_hsa051681.70114352
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.63896358
21Sulfur relay system_Homo sapiens_hsa041221.60236573
22Rheumatoid arthritis_Homo sapiens_hsa053231.49543310
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48763530
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47734997
25Nucleotide excision repair_Homo sapiens_hsa034201.44368251
26Homologous recombination_Homo sapiens_hsa034401.36388297
27Spliceosome_Homo sapiens_hsa030401.35063192
28Legionellosis_Homo sapiens_hsa051341.32090107
29Acute myeloid leukemia_Homo sapiens_hsa052211.31965391
30Epstein-Barr virus infection_Homo sapiens_hsa051691.31538254
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.30784024
32Proteasome_Homo sapiens_hsa030501.28803765
33RNA polymerase_Homo sapiens_hsa030201.27868853
34T cell receptor signaling pathway_Homo sapiens_hsa046601.26559462
35Other glycan degradation_Homo sapiens_hsa005111.25566102
36Pyrimidine metabolism_Homo sapiens_hsa002401.24772960
37Pentose phosphate pathway_Homo sapiens_hsa000301.23538277
38p53 signaling pathway_Homo sapiens_hsa041151.20617314
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.20036699
40Influenza A_Homo sapiens_hsa051641.19041753
41Osteoclast differentiation_Homo sapiens_hsa043801.17545225
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14971002
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13821614
44Toxoplasmosis_Homo sapiens_hsa051451.13584440
45Shigellosis_Homo sapiens_hsa051311.09308733
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.08678820
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.08382723
48Apoptosis_Homo sapiens_hsa042101.07728472
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06317757
50Fructose and mannose metabolism_Homo sapiens_hsa000511.03493290
51RNA transport_Homo sapiens_hsa030131.00306583
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00150791
53Viral myocarditis_Homo sapiens_hsa054160.97994535
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97341010
55Galactose metabolism_Homo sapiens_hsa000520.97002651
56HTLV-I infection_Homo sapiens_hsa051660.96225525
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95520042
58Platelet activation_Homo sapiens_hsa046110.90123135
59HIF-1 signaling pathway_Homo sapiens_hsa040660.89798215
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88717726
61Cell cycle_Homo sapiens_hsa041100.87537703
62Hepatitis B_Homo sapiens_hsa051610.87433932
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86945441
64Viral carcinogenesis_Homo sapiens_hsa052030.84137603
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82164439
66RNA degradation_Homo sapiens_hsa030180.80967084
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80052335
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78171589
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77826794
70Tuberculosis_Homo sapiens_hsa051520.77359054
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76436125
72One carbon pool by folate_Homo sapiens_hsa006700.76107601
73Allograft rejection_Homo sapiens_hsa053300.72485005
74Purine metabolism_Homo sapiens_hsa002300.71907875
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.71384024
76Bladder cancer_Homo sapiens_hsa052190.71115353
77Phagosome_Homo sapiens_hsa041450.69730950
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67768610
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67737155
80Malaria_Homo sapiens_hsa051440.67509812
81Chronic myeloid leukemia_Homo sapiens_hsa052200.67249267
82Notch signaling pathway_Homo sapiens_hsa043300.67180857
83Endocytosis_Homo sapiens_hsa041440.67023919
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66454495
85Sphingolipid metabolism_Homo sapiens_hsa006000.66129424
86Fanconi anemia pathway_Homo sapiens_hsa034600.65969927
87Folate biosynthesis_Homo sapiens_hsa007900.65635406
88Insulin resistance_Homo sapiens_hsa049310.65447812
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.65178602
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63420801
91Non-homologous end-joining_Homo sapiens_hsa034500.62196854
92mTOR signaling pathway_Homo sapiens_hsa041500.61613322
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.60967329
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60626242
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.60476613
96African trypanosomiasis_Homo sapiens_hsa051430.60143344
97TNF signaling pathway_Homo sapiens_hsa046680.58758341
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58128590
99Small cell lung cancer_Homo sapiens_hsa052220.58057714
100Pertussis_Homo sapiens_hsa051330.56838252
101Non-small cell lung cancer_Homo sapiens_hsa052230.56538578
102Insulin signaling pathway_Homo sapiens_hsa049100.56420196
103Biosynthesis of amino acids_Homo sapiens_hsa012300.56054958
104ABC transporters_Homo sapiens_hsa020100.55064374
105Graft-versus-host disease_Homo sapiens_hsa053320.54256004
106Sulfur metabolism_Homo sapiens_hsa009200.54042654
107Hepatitis C_Homo sapiens_hsa051600.52799618
108VEGF signaling pathway_Homo sapiens_hsa043700.49506402
109Prolactin signaling pathway_Homo sapiens_hsa049170.49246290
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49188683
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49130410
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48972286
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47930227
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.47200669
115Carbon metabolism_Homo sapiens_hsa012000.46136197
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45698684
117Thyroid cancer_Homo sapiens_hsa052160.45557238
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43360395
119GnRH signaling pathway_Homo sapiens_hsa049120.43020629
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41904427
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.41878803
122Chemokine signaling pathway_Homo sapiens_hsa040620.41795752
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41424559
124Pancreatic cancer_Homo sapiens_hsa052120.40837924
125Salmonella infection_Homo sapiens_hsa051320.40330515
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39325826
127Caffeine metabolism_Homo sapiens_hsa002320.39160977
128Inositol phosphate metabolism_Homo sapiens_hsa005620.38917265
129Systemic lupus erythematosus_Homo sapiens_hsa053220.38021569
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37543455
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37229704
132Arachidonic acid metabolism_Homo sapiens_hsa005900.36340182
133MAPK signaling pathway_Homo sapiens_hsa040100.36079282
134FoxO signaling pathway_Homo sapiens_hsa040680.35425034
135Choline metabolism in cancer_Homo sapiens_hsa052310.35214291
136Basal transcription factors_Homo sapiens_hsa030220.34800511
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34288810
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.33937676
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33455063
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30111415
141Regulation of autophagy_Homo sapiens_hsa041400.27588468
142Ovarian steroidogenesis_Homo sapiens_hsa049130.26577557

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