RABGEF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal cone cell development (GO:0046549)6.80871868
2GMP metabolic process (GO:0046037)6.53525716
3photoreceptor cell development (GO:0042461)6.48951605
4eye photoreceptor cell development (GO:0042462)6.17893454
5regulation of vitamin D biosynthetic process (GO:0060556)5.87575209
6positive regulation of guanylate cyclase activity (GO:0031284)5.81910007
7photoreceptor cell maintenance (GO:0045494)5.49635887
8phototransduction, visible light (GO:0007603)5.21609343
9phototransduction (GO:0007602)5.21221260
10regulation of guanylate cyclase activity (GO:0031282)5.19381498
11detection of light stimulus (GO:0009583)4.96923891
12detection of visible light (GO:0009584)4.90791958
13detection of light stimulus involved in sensory perception (GO:0050962)4.61573972
14detection of light stimulus involved in visual perception (GO:0050908)4.61573972
15regulation of vitamin metabolic process (GO:0030656)4.35786349
16neutrophil activation involved in immune response (GO:0002283)4.24779922
17positive regulation of heat generation (GO:0031652)4.19104692
18regulation of fever generation (GO:0031620)4.08830642
19cellular response to light stimulus (GO:0071482)4.07029514
20visual perception (GO:0007601)4.05879551
21sensory perception of light stimulus (GO:0050953)3.98351842
22retinal rod cell development (GO:0046548)3.82212789
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.77822896
24positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.66251413
25response to peptidoglycan (GO:0032494)3.58412940
26positive regulation by symbiont of host defense response (GO:0052509)3.54455875
27modulation by symbiont of host defense response (GO:0052031)3.54455875
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.54455875
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.54455875
30positive regulation by organism of defense response of other organism involved in symbiotic interact3.54455875
31modulation by symbiont of host immune response (GO:0052553)3.54455875
32cellular response to arsenic-containing substance (GO:0071243)3.49243569
33cellular response to thyroid hormone stimulus (GO:0097067)3.43898491
34lipopolysaccharide-mediated signaling pathway (GO:0031663)3.37179764
35regulation of mononuclear cell migration (GO:0071675)3.35895705
36protein-chromophore linkage (GO:0018298)3.35214254
37granulocyte activation (GO:0036230)3.34895426
38detection of external stimulus (GO:0009581)3.31744355
39positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.31686086
40positive regulation of chemokine biosynthetic process (GO:0045080)3.29572628
41regulation of cGMP metabolic process (GO:0030823)3.27496429
42negative regulation of nitric oxide biosynthetic process (GO:0045019)3.27407996
43germinal center formation (GO:0002467)3.27369760
44natural killer cell mediated immunity (GO:0002228)3.26322507
45natural killer cell mediated cytotoxicity (GO:0042267)3.26322507
46ADP metabolic process (GO:0046031)3.25084010
47detection of abiotic stimulus (GO:0009582)3.24903082
48wound healing, spreading of epidermal cells (GO:0035313)3.24006888
49positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.23124410
50regulation of chronic inflammatory response (GO:0002676)3.23103753
51regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.21522449
52regulation of T-helper 2 cell differentiation (GO:0045628)3.17911918
53response to muramyl dipeptide (GO:0032495)3.17203362
54positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.14799537
55positive regulation of interferon-alpha production (GO:0032727)3.13719847
56regulation of interleukin-12 biosynthetic process (GO:0045075)3.12561525
57positive regulation of cGMP biosynthetic process (GO:0030828)3.11873211
58photoreceptor cell differentiation (GO:0046530)3.07386149
59eye photoreceptor cell differentiation (GO:0001754)3.07386149
60neutrophil activation (GO:0042119)3.07047022
61negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.05945708
62regulation of memory T cell differentiation (GO:0043380)3.05840744
63cell adhesion mediated by integrin (GO:0033627)3.05445066
64piRNA metabolic process (GO:0034587)3.04314472
65regulation of membrane protein ectodomain proteolysis (GO:0051043)3.02808322
66detection of molecule of bacterial origin (GO:0032490)3.02692816
67protein localization to endosome (GO:0036010)3.02371297
68negative regulation of monooxygenase activity (GO:0032769)2.99007090
69regulation of interferon-alpha production (GO:0032647)2.98925851
70negative regulation of lipid storage (GO:0010888)2.98353545
71production of molecular mediator involved in inflammatory response (GO:0002532)2.91083508
72NIK/NF-kappaB signaling (GO:0038061)2.90720673
73regulation of podosome assembly (GO:0071801)2.89431789
74macrophage activation involved in immune response (GO:0002281)2.89258538
75regulation of heat generation (GO:0031650)2.89012458
76regulation of cGMP biosynthetic process (GO:0030826)2.88663389
77retina development in camera-type eye (GO:0060041)2.88543069
78eosinophil chemotaxis (GO:0048245)2.86432724
79immunoglobulin mediated immune response (GO:0016064)2.85216829
80positive regulation of p38MAPK cascade (GO:1900745)2.83643104
81regulation of dendritic cell antigen processing and presentation (GO:0002604)2.82079033
82positive regulation of natural killer cell activation (GO:0032816)2.81997308
83positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.81435808
84membrane raft organization (GO:0031579)2.80692990
85cellular response to radiation (GO:0071478)2.80558397
86hydrogen peroxide biosynthetic process (GO:0050665)2.79503825
87positive regulation of T-helper cell differentiation (GO:0045624)2.78965459
88positive regulation of interferon-beta production (GO:0032728)2.78239268
89cellular response to lipopolysaccharide (GO:0071222)2.76769409
90monocyte chemotaxis (GO:0002548)2.76444602
91positive regulation of interleukin-17 production (GO:0032740)2.76195705
92regulation of nitric oxide biosynthetic process (GO:0045428)2.75701451
93positive regulation of NF-kappaB import into nucleus (GO:0042346)2.75132729
94intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.74375766
95superoxide anion generation (GO:0042554)2.73570024
96skeletal muscle adaptation (GO:0043501)2.73498235
97regulation of RIG-I signaling pathway (GO:0039535)2.72519578
98regulation of immunoglobulin secretion (GO:0051023)2.72438331
99regulation of interleukin-8 biosynthetic process (GO:0045414)2.72119879
100negative regulation of interleukin-12 production (GO:0032695)2.71359062
101amino sugar catabolic process (GO:0046348)2.70740069
102respiratory burst (GO:0045730)2.70038899
103interferon-gamma-mediated signaling pathway (GO:0060333)2.69839878
104positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.69211983
105positive regulation of interleukin-6 production (GO:0032755)2.69187512
106cellular response to molecule of bacterial origin (GO:0071219)2.68094460
107regulation of T-helper cell differentiation (GO:0045622)2.67607924
108positive regulation of cellular amide metabolic process (GO:0034250)2.66415099
109regulation of natural killer cell activation (GO:0032814)2.65480751
110positive regulation of type 2 immune response (GO:0002830)2.64292480
111cellular response to virus (GO:0098586)2.63004760
112response to thyroid hormone (GO:0097066)2.61718717
113positive regulation of nitric oxide biosynthetic process (GO:0045429)2.61371962
114detection of external biotic stimulus (GO:0098581)2.60642276
115detection of other organism (GO:0098543)2.59653054
116regulation of interleukin-17 production (GO:0032660)2.59145837
117activation of MAPKKK activity (GO:0000185)2.58242879
118positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.57534812
119leukocyte aggregation (GO:0070486)2.55694092
120regulation of T-helper 1 cell differentiation (GO:0045625)2.55567878
121positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.54750636
122positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.54464748
123regulation of macrophage chemotaxis (GO:0010758)2.54401747
124positive regulation of chemokine production (GO:0032722)2.54246722
125regulation of clathrin-mediated endocytosis (GO:2000369)2.53320262
126mature B cell differentiation involved in immune response (GO:0002313)2.53083557
127regulation of NF-kappaB import into nucleus (GO:0042345)2.52662111
128decidualization (GO:0046697)2.52477981
129receptor guanylyl cyclase signaling pathway (GO:0007168)2.52090369
130low-density lipoprotein particle clearance (GO:0034383)2.51958273
131sphingosine metabolic process (GO:0006670)2.51286236
132negative regulation of interleukin-17 production (GO:0032700)2.49720668
133regulation of fibroblast apoptotic process (GO:2000269)2.48560600
134regulation of activation of Janus kinase activity (GO:0010533)2.48173419
135regulation of cytokine secretion involved in immune response (GO:0002739)2.48157032
136eosinophil migration (GO:0072677)2.48050552
137chaperone mediated protein folding requiring cofactor (GO:0051085)2.47856601
138regulation of chemokine biosynthetic process (GO:0045073)2.47834650
139positive regulation of natural killer cell differentiation (GO:0032825)2.47616585
140positive regulation of cGMP metabolic process (GO:0030825)2.47093270
141regulation of NFAT protein import into nucleus (GO:0051532)2.45611971
142positive regulation of macrophage cytokine production (GO:0060907)2.45116961
143response to host immune response (GO:0052572)2.44836856
144response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.44836856
145negative regulation of bone mineralization (GO:0030502)2.44552906
146cyclooxygenase pathway (GO:0019371)2.43988514
147positive regulation of monocyte chemotaxis (GO:0090026)2.43105137
148cellular response to biotic stimulus (GO:0071216)2.42904088
149skin morphogenesis (GO:0043589)2.42892639
150positive regulation of osteoclast differentiation (GO:0045672)2.41840444
151regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.41188925
152phagosome maturation (GO:0090382)2.40584594
153myeloid dendritic cell differentiation (GO:0043011)2.40128256
154regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.40038153
155positive regulation of leukocyte apoptotic process (GO:2000108)2.40011530
156cellular response to nicotine (GO:0071316)2.39565357
157positive regulation of toll-like receptor signaling pathway (GO:0034123)2.37573456
158neutrophil mediated immunity (GO:0002446)2.37200943
159regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.37175574
160T-helper 1 type immune response (GO:0042088)2.36225273
161negative regulation of biomineral tissue development (GO:0070168)2.34855054
162regulation of interferon-beta biosynthetic process (GO:0045357)2.33201208
163glycosphingolipid catabolic process (GO:0046479)2.32613682
164cell wall macromolecule metabolic process (GO:0044036)2.32195630
165regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.30378961
166regulation of monocyte chemotaxis (GO:0090025)2.28917137
167regulation of vascular endothelial growth factor production (GO:0010574)2.28314653
168response to progesterone (GO:0032570)2.27494498
169membrane protein intracellular domain proteolysis (GO:0031293)2.26308615
170response to arsenic-containing substance (GO:0046685)2.25737815
171cellular response to interferon-alpha (GO:0035457)2.25149238
172regulation of rhodopsin mediated signaling pathway (GO:0022400)10.5834853
173rhodopsin mediated signaling pathway (GO:0016056)10.2330865

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.19187624
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.17179616
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.09692449
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.36794427
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.61440939
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.03215034
7IRF8_27001747_Chip-Seq_BMDM_Mouse2.90045618
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.83787353
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.82864937
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.81434185
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.74204600
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.73499434
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68647593
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.56776249
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.56527566
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.46107743
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.43527254
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.25967470
19* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.23264220
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.20729095
21GATA2_21666600_ChIP-Seq_HMVEC_Human1.92645766
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.82889305
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.82464219
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77734442
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72458131
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.70919362
27PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.70044381
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.69924565
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.67569339
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64139273
31ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.63127106
32* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60487284
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56067770
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54786898
35CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.51087432
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48945061
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44893025
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.42543809
39CJUN_26792858_Chip-Seq_BT549_Human1.41657811
40PU_27001747_Chip-Seq_BMDM_Mouse1.41476205
41VDR_24787735_ChIP-Seq_THP-1_Human1.40519765
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40079908
43TP53_16413492_ChIP-PET_HCT116_Human1.39209674
44CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38252239
45TRIM28_21343339_ChIP-Seq_HEK293_Human1.37875223
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.36056653
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.32815310
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32640594
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31831869
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31399588
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31399588
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28085620
53JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27024342
54CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26032058
55SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25699422
56SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25699422
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23056124
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22173127
59JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21368355
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20366996
61RUNX_20019798_ChIP-Seq_JUKART_Human1.19378117
62* SPI1_23547873_ChIP-Seq_NB4_Human1.18440832
63UBF1/2_26484160_Chip-Seq_HMECs_Human1.17184782
64KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.17097877
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.16708026
66GATA3_26560356_Chip-Seq_TH2_Human1.12276483
67CLOCK_20551151_ChIP-Seq_293T_Human1.11987314
68PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10567930
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10081730
70IGF1R_20145208_ChIP-Seq_DFB_Human1.08712155
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07971573
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06995634
73FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.06896012
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06226024
75ATF3_27146783_Chip-Seq_COLON_Human1.05554512
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05450032
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02089813
78MYB_26560356_Chip-Seq_TH1_Human1.01939346
79SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01894568
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01514128
81EGR1_19032775_ChIP-ChIP_M12_Human1.00110256
82FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00047690
83MYB_26560356_Chip-Seq_TH2_Human0.99660727
84GATA1_19941827_ChIP-Seq_MEL_Mouse0.99537842
85FOXO3_23340844_ChIP-Seq_DLD1_Human0.98387827
86* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97438700
87* TP63_23658742_ChIP-Seq_EP156T_Human0.96788415
88PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96627678
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96346810
90SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95472153
91* SPI1_23127762_ChIP-Seq_K562_Human0.94953998
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94414061
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94199128
94SMRT_27268052_Chip-Seq_Bcells_Human0.93574907
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93030299
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91547883
97ESR1_20079471_ChIP-ChIP_T-47D_Human0.91389679
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89529996
99CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87909457
100EP300_21415370_ChIP-Seq_HL-1_Mouse0.87202479
101P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87019508
102RXR_22108803_ChIP-Seq_LS180_Human0.86947016
103* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.86810016
104ELK3_25401928_ChIP-Seq_HUVEC_Human0.86782423
105* GATA2_19941826_ChIP-Seq_K562_Human0.86646145
106CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86492012
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85751925
108GATA3_27048872_Chip-Seq_THYMUS_Human0.85472066
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84891085
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84840817
111* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83856592
112NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83740029
113GATA1_19941826_ChIP-Seq_K562_Human0.83513919
114EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83283535
115MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.81591940
116WT1_19549856_ChIP-ChIP_CCG9911_Human0.80431760
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79429249
118GATA2_22383799_ChIP-Seq_G1ME_Mouse0.77947037
119SOX2_20726797_ChIP-Seq_SW620_Human0.74710575
120E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.73109953
121GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72833646
122BRD4_25478319_ChIP-Seq_HGPS_Human0.72703109
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71891309
124TFEB_21752829_ChIP-Seq_HELA_Human0.69981025
125* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.69375345

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation6.16302980
2MP0005551_abnormal_eye_electrophysiolog5.58492414
3MP0005253_abnormal_eye_physiology3.65718479
4MP0003950_abnormal_plasma_membrane3.45711716
5MP0003436_decreased_susceptibility_to3.15197033
6MP0001835_abnormal_antigen_presentation2.91611562
7MP0006072_abnormal_retinal_apoptosis2.82138761
8MP0006054_spinal_hemorrhage2.80068407
9MP0008438_abnormal_cutaneous_collagen2.68407317
10MP0002148_abnormal_hypersensitivity_rea2.60189714
11MP0002638_abnormal_pupillary_reflex2.54136928
12MP0003303_peritoneal_inflammation2.53812454
13MP0009785_altered_susceptibility_to2.36736314
14MP0001324_abnormal_eye_pigmentation2.33535736
15MP0003724_increased_susceptibility_to2.25616926
16MP0002419_abnormal_innate_immunity2.23932481
17MP0005000_abnormal_immune_tolerance2.16322787
18MP0004510_myositis2.13145490
19MP0005195_abnormal_posterior_eye1.98056575
20MP0001533_abnormal_skeleton_physiology1.96491507
21MP0003646_muscle_fatigue1.91851136
22MP0005076_abnormal_cell_differentiation1.81561049
23MP0004947_skin_inflammation1.81552867
24MP0006082_CNS_inflammation1.80959814
25MP0001853_heart_inflammation1.80954287
26MP0005387_immune_system_phenotype1.80157969
27MP0001790_abnormal_immune_system1.80157969
28MP0002877_abnormal_melanocyte_morpholog1.79201136
29MP0005167_abnormal_blood-brain_barrier1.78835620
30* MP0002452_abnormal_antigen_presenting1.74017153
31MP0005025_abnormal_response_to1.73447086
32MP0005023_abnormal_wound_healing1.73216791
33MP0002090_abnormal_vision1.64159072
34MP0009764_decreased_sensitivity_to1.62832646
35MP0004782_abnormal_surfactant_physiolog1.58096794
36* MP0002723_abnormal_immune_serum1.55214097
37MP0005671_abnormal_response_to1.53970709
38MP0000749_muscle_degeneration1.52678140
39MP0002332_abnormal_exercise_endurance1.52473693
40MP0003656_abnormal_erythrocyte_physiolo1.51569059
41MP0010352_gastrointestinal_tract_polyps1.50966604
42MP0003448_altered_tumor_morphology1.50087936
43MP0010678_abnormal_skin_adnexa1.50077483
44MP0000343_altered_response_to1.49517076
45MP0005391_vision/eye_phenotype1.47420025
46MP0005310_abnormal_salivary_gland1.46364460
47MP0000383_abnormal_hair_follicle1.44932868
48MP0005451_abnormal_body_composition1.44550218
49MP0005397_hematopoietic_system_phenotyp1.44085371
50MP0001545_abnormal_hematopoietic_system1.44085371
51MP0000685_abnormal_immune_system1.43893422
52MP0003075_altered_response_to1.43833024
53* MP0001800_abnormal_humoral_immune1.41706318
54MP0003172_abnormal_lysosome_physiology1.40378569
55MP0002138_abnormal_hepatobiliary_system1.37922236
56* MP0001819_abnormal_immune_cell1.37219409
57MP0002405_respiratory_system_inflammati1.33079733
58* MP0002420_abnormal_adaptive_immunity1.32600110
59* MP0001845_abnormal_inflammatory_respons1.27523177
60MP0009278_abnormal_bone_marrow1.27410082
61MP0005164_abnormal_response_to1.26291473
62MP0002060_abnormal_skin_morphology1.20949158
63MP0001542_abnormal_bone_strength1.19675403
64MP0003300_gastrointestinal_ulcer1.19184145
65MP0010307_abnormal_tumor_latency1.18537064
66MP0000858_altered_metastatic_potential1.18007174
67MP0002254_reproductive_system_inflammat1.17407737
68MP0005165_increased_susceptibility_to1.17292181
69MP0002998_abnormal_bone_remodeling1.16434765
70MP0002277_abnormal_respiratory_mucosa1.15749374
71MP0000013_abnormal_adipose_tissue1.14124175
72MP0000604_amyloidosis1.11229297
73MP0002933_joint_inflammation1.10843882
74MP0009763_increased_sensitivity_to1.10699488
75MP0005464_abnormal_platelet_physiology1.09128985
76MP0010155_abnormal_intestine_physiology1.06834530
77MP0005058_abnormal_lysosome_morphology1.05196050
78MP0002229_neurodegeneration1.03897208
79MP0000569_abnormal_digit_pigmentation1.02621821
80MP0005257_abnormal_intraocular_pressure1.02387280
81MP0005390_skeleton_phenotype1.02331064
82MP0001958_emphysema1.01976380
83MP0000427_abnormal_hair_cycle0.98597321
84MP0002006_tumorigenesis0.97995652
85MP0005166_decreased_susceptibility_to0.97590523
86MP0000750_abnormal_muscle_regeneration0.97391094
87* MP0001216_abnormal_epidermal_layer0.97350771
88MP0003453_abnormal_keratinocyte_physiol0.95629719
89MP0010234_abnormal_vibrissa_follicle0.95024747
90MP0001986_abnormal_taste_sensitivity0.94263885
91MP0009765_abnormal_xenobiotic_induced0.93704013
92MP0008004_abnormal_stomach_pH0.93409973
93MP0002295_abnormal_pulmonary_circulatio0.92962116
94MP0003191_abnormal_cellular_cholesterol0.92140629
95MP0003183_abnormal_peptide_metabolism0.91235490
96MP0003279_aneurysm0.91057734
97MP0001191_abnormal_skin_condition0.89862224
98MP0005197_abnormal_uvea_morphology0.89632266
99MP0009333_abnormal_splenocyte_physiolog0.89605469
100MP0003045_fibrosis0.88721436
101MP0008469_abnormal_protein_level0.87337870
102MP0004883_abnormal_blood_vessel0.86938829
103MP0005275_abnormal_skin_tensile0.85682765
104* MP0001764_abnormal_homeostasis0.84898032
105MP0010386_abnormal_urinary_bladder0.84469605
106MP0003705_abnormal_hypodermis_morpholog0.84155228
107* MP0000716_abnormal_immune_system0.83449143
108* MP0001243_abnormal_dermal_layer0.83065019
109MP0005595_abnormal_vascular_smooth0.81280859
110MP0010368_abnormal_lymphatic_system0.80685102
111MP0003566_abnormal_cell_adhesion0.80084055
112MP0005410_abnormal_fertilization0.79621068
113MP0003806_abnormal_nucleotide_metabolis0.79578901
114MP0008874_decreased_physiological_sensi0.79322607
115MP0000015_abnormal_ear_pigmentation0.79207983
116MP0003828_pulmonary_edema0.78666646
117MP0002398_abnormal_bone_marrow0.78307417
118MP0002896_abnormal_bone_mineralization0.76622629
119MP0000920_abnormal_myelination0.73248163
120MP0000249_abnormal_blood_vessel0.72722295
121MP0001501_abnormal_sleep_pattern0.70967313
122MP0005584_abnormal_enzyme/coenzyme_acti0.68862743
123MP0002106_abnormal_muscle_physiology0.68338403
124MP0001851_eye_inflammation0.67481840
125* MP0002429_abnormal_blood_cell0.66664613
126MP0003091_abnormal_cell_migration0.66419951
127MP0003795_abnormal_bone_structure0.65715248
128MP0000689_abnormal_spleen_morphology0.64528190
129MP0009840_abnormal_foam_cell0.63881475
130MP0000767_abnormal_smooth_muscle0.61001505
131MP0008260_abnormal_autophagy0.59801739
132* MP0005376_homeostasis/metabolism_phenot0.58529068
133MP0005621_abnormal_cell_physiology0.58289978
134MP0005620_abnormal_muscle_contractility0.58205258
135MP0004145_abnormal_muscle_electrophysio0.56859364

Predicted human phenotypes

RankGene SetZ-score
1Bony spicule pigmentary retinopathy (HP:0007737)8.65138000
2Pigmentary retinal degeneration (HP:0001146)8.13592382
3Chorioretinal atrophy (HP:0000533)7.55822235
4Abnormal rod and cone electroretinograms (HP:0008323)7.51059259
5Absent rod-and cone-mediated responses on ERG (HP:0007688)6.99818384
6Attenuation of retinal blood vessels (HP:0007843)5.84571499
7Pendular nystagmus (HP:0012043)5.84127840
8Central scotoma (HP:0000603)5.39762160
9Abnormality of liposaccharide metabolism (HP:0010968)5.25024421
10Abnormality of glycosphingolipid metabolism (HP:0004343)5.25024421
11Abnormality of glycolipid metabolism (HP:0010969)5.25024421
12Abnormality of macular pigmentation (HP:0008002)4.84591024
13Scotoma (HP:0000575)4.80831230
14Dyschromatopsia (HP:0007641)4.79170773
15Vitreoretinal degeneration (HP:0000655)4.47563635
16Photophobia (HP:0000613)4.31106555
17Abolished electroretinogram (ERG) (HP:0000550)4.26193720
18Cone-rod dystrophy (HP:0000548)4.18902340
19Vacuolated lymphocytes (HP:0001922)4.02102430
20Decreased central vision (HP:0007663)3.93884630
21Choroideremia (HP:0001139)3.90855519
22Type II diabetes mellitus (HP:0005978)3.79734737
23Macular degeneration (HP:0000608)3.68279271
24Dysostosis multiplex (HP:0000943)3.64805176
25Progressive visual loss (HP:0000529)3.55659028
26Elevated erythrocyte sedimentation rate (HP:0003565)3.52802316
27Interstitial pulmonary disease (HP:0006530)3.48522957
28Retrobulbar optic neuritis (HP:0100654)3.47362448
29Optic neuritis (HP:0100653)3.47362448
30Orchitis (HP:0100796)3.46745619
31Eczematoid dermatitis (HP:0000976)3.45118408
32Recurrent abscess formation (HP:0002722)3.35950385
33Constricted visual fields (HP:0001133)3.23688503
34Increased corneal curvature (HP:0100692)3.19212683
35Keratoconus (HP:0000563)3.19212683
36Tetraparesis (HP:0002273)3.17931199
37Nuclear cataract (HP:0100018)3.17927926
38Recurrent bacterial skin infections (HP:0005406)3.10284546
39Retinitis pigmentosa (HP:0000510)3.09594304
40Myositis (HP:0100614)3.00955601
41Prostate neoplasm (HP:0100787)2.80846261
42Follicular hyperkeratosis (HP:0007502)2.80493941
43Neurofibrillary tangles (HP:0002185)2.78541551
44Abnormality of mucopolysaccharide metabolism (HP:0011020)2.77653568
45Abnormality of polysaccharide metabolism (HP:0011012)2.77653568
46Abnormality of glycosaminoglycan metabolism (HP:0004371)2.77653568
47Gangrene (HP:0100758)2.76932303
48Recurrent gram-negative bacterial infections (HP:0005420)2.72252804
49Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.65746600
50Osteolytic defects of the hand bones (HP:0009699)2.65127918
51Osteolytic defects of the phalanges of the hand (HP:0009771)2.65127918
52Loss of speech (HP:0002371)2.60135593
53Autoamputation (HP:0001218)2.60091119
54Spondylolisthesis (HP:0003302)2.59752403
55Upper motor neuron abnormality (HP:0002127)2.57298877
56Urinary glycosaminoglycan excretion (HP:0003541)2.55639002
57Mucopolysacchariduria (HP:0008155)2.55639002
58Posterior subcapsular cataract (HP:0007787)2.49037452
59Mediastinal lymphadenopathy (HP:0100721)2.41024834
60Short middle phalanx of the 5th finger (HP:0004220)2.38430759
61Autoimmune thrombocytopenia (HP:0001973)2.38188424
62Abnormality of macrophages (HP:0004311)2.35373671
63Premature rupture of membranes (HP:0001788)2.30756738
64Apathy (HP:0000741)2.30201082
65Diminished motivation (HP:0000745)2.29695811
66Mutism (HP:0002300)2.29555457
67Stomatitis (HP:0010280)2.29398811
68Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22685802
69Cutaneous melanoma (HP:0012056)2.21939869
70Parakeratosis (HP:0001036)2.20626561
71Cervical subluxation (HP:0003308)2.20071639
72Entropion (HP:0000621)2.19263865
73Muscle fiber inclusion bodies (HP:0100299)2.18314025
74Polyneuropathy (HP:0001271)2.17740530
75Exercise-induced muscle cramps (HP:0003710)2.17232260
76Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.12802122
77Peritonitis (HP:0002586)2.11072115
78Keratoconjunctivitis sicca (HP:0001097)2.10421555
79Ankle contracture (HP:0006466)2.08879951
80Keratitis (HP:0000491)2.08660491
81Amyotrophic lateral sclerosis (HP:0007354)2.06180559
82Glomerulopathy (HP:0100820)2.05837854
83Fatigue (HP:0012378)2.05741605
84Abnormality of the costochondral junction (HP:0000919)2.04534453
85Abnormality of the vasculature of the conjunctiva (HP:0008054)2.03156747
86Erythema (HP:0010783)2.03045647
87Aortic dissection (HP:0002647)2.02473996
88Ulnar deviation of the wrist (HP:0003049)2.00970008
89Congenital stationary night blindness (HP:0007642)10.8151114
90Short nail (HP:0001799)1.99458088
91Retinal atrophy (HP:0001105)1.97853657
92Distal arthrogryposis (HP:0005684)1.97675049
93Increased neuronal autofluorescent lipopigment (HP:0002074)1.97444135
94Vasculitis (HP:0002633)1.96352196
95Cerebral inclusion bodies (HP:0100314)1.95601509
96Increased IgM level (HP:0003496)1.95236618
97Supranuclear gaze palsy (HP:0000605)1.94965496
98Irregular epiphyses (HP:0010582)1.94485196
99Abnormality of the pericardium (HP:0001697)1.94467915
100Increased cerebral lipofuscin (HP:0011813)1.93379193
101Gastrointestinal infarctions (HP:0005244)1.93335875
102Neuronal loss in central nervous system (HP:0002529)1.92502803
103Disinhibition (HP:0000734)1.92257160
104Nemaline bodies (HP:0003798)1.91680575
105Arthropathy (HP:0003040)1.90205472
106Upper limb muscle weakness (HP:0003484)1.89970143
107Amyloidosis (HP:0011034)1.88789770
108Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88629232
109Myocardial infarction (HP:0001658)1.87874882
110Reduced subcutaneous adipose tissue (HP:0003758)1.87555101
111Hepatosplenomegaly (HP:0001433)1.86334231
112Increased serum ferritin (HP:0003281)1.84967515
113Keratoconjunctivitis (HP:0001096)1.84445117
114Gingivitis (HP:0000230)1.82672846
115Increased connective tissue (HP:0009025)1.82314032
116Frequent falls (HP:0002359)1.81388230
117Congenital ichthyosiform erythroderma (HP:0007431)1.80968261
118Axonal loss (HP:0003447)1.79151258
119Wormian bones (HP:0002645)1.78007786
120Severe visual impairment (HP:0001141)1.77401950
121Muscle fiber splitting (HP:0003555)1.74499986
122Alopecia of scalp (HP:0002293)1.74054649
123Ectropion (HP:0000656)1.73427210
124Asymmetric septal hypertrophy (HP:0001670)1.72860331
125Menstrual irregularities (HP:0000858)1.72213106
126Aortic aneurysm (HP:0004942)1.72178966
127Abnormal blistering of the skin (HP:0008066)1.71219182
128Pustule (HP:0200039)1.70832901
129Optic disc pallor (HP:0000543)1.70351473
130Premature loss of primary teeth (HP:0006323)1.70317702
131Pulmonary infiltrates (HP:0002113)1.70124826
132Increased IgE level (HP:0003212)1.69506542
133Eosinophilia (HP:0001880)1.68314786
134Vertigo (HP:0002321)1.67615176
135Glucose intolerance (HP:0000833)1.67228411
136Dilatation of the ascending aorta (HP:0005111)1.66486917
137Abnormality of nail color (HP:0100643)1.65501305
138Type 1 muscle fiber predominance (HP:0003803)1.65407862
139Protrusio acetabuli (HP:0003179)1.64880978
140Thick nail (HP:0001805)1.64525640
141Congenital primary aphakia (HP:0007707)1.62979923
142Vertebral compression fractures (HP:0002953)1.62524552
143Metaphyseal irregularity (HP:0003025)1.62420895
144Episodic fever (HP:0001954)1.61709814
145Erythroderma (HP:0001019)1.61070219
146Prolonged bleeding time (HP:0003010)1.60928760
147Arterial thrombosis (HP:0004420)1.60750771
148Wide nasal bridge (HP:0000431)1.60377551
149Petechiae (HP:0000967)1.60295008
150Albinism (HP:0001022)1.59822113
151Rough bone trabeculation (HP:0100670)1.59195341
152Metaphyseal cupping (HP:0003021)1.58951283
153Natal tooth (HP:0000695)1.57120893
154Exercise-induced myalgia (HP:0003738)1.55816870
155Gait imbalance (HP:0002141)1.55749175
156Urticaria (HP:0001025)1.55338936
157Flat capital femoral epiphysis (HP:0003370)1.55292058
158Systemic lupus erythematosus (HP:0002725)1.53160063
159Recurrent fungal infections (HP:0002841)1.51186217
160Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.50218629
161Anorexia (HP:0002039)1.50031661
162Recurrent skin infections (HP:0001581)1.49475066
163Spinal muscular atrophy (HP:0007269)1.47242749
164Hypoplastic ischia (HP:0003175)1.44364557
165Horizontal nystagmus (HP:0000666)1.43974672
166Hypoplasia of the fovea (HP:0007750)1.40705388
167Aplasia/Hypoplasia of the fovea (HP:0008060)1.40705388
168Subcapsular cataract (HP:0000523)1.40088093
169Myopathic facies (HP:0002058)1.39980300
170Persistence of primary teeth (HP:0006335)1.39004888
171Epiphyseal dysplasia (HP:0002656)1.38824610
172Chronic obstructive pulmonary disease (HP:0006510)1.37125196
173Obstructive lung disease (HP:0006536)1.37125196
174Distal lower limb muscle weakness (HP:0009053)1.34124698
175Submucous cleft hard palate (HP:0000176)1.33416704

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.10227360
2GRK14.30503892
3MAP3K144.12789415
4IRAK33.53061397
5TBK12.85584172
6TESK22.79416253
7AKT32.56697571
8PIM22.49497916
9RIPK42.39295235
10TAOK32.33926517
11CHUK2.04094916
12TESK12.04079008
13IKBKB2.01806475
14ERBB31.78821676
15STK241.77372970
16LIMK11.77052603
17PINK11.76792861
18TRPM71.76703111
19IKBKE1.76145509
20GRK71.75489849
21RPS6KA41.74803505
22IRAK41.62602293
23ERN11.60431154
24TYK21.57307732
25EIF2AK31.55642844
26IRAK11.50103540
27MST41.49649252
28MAP3K31.46686157
29MYLK1.42708147
30FGR1.41003394
31PRPF4B1.40955369
32PTK2B1.37845022
33TTN1.37708773
34PIM11.36521500
35MET1.36488890
36BRSK21.34960636
37PLK21.32447191
38NME21.26974012
39SIK31.19015224
40JAK11.17670716
41LATS21.17545632
42JAK31.15915847
43MARK31.15244227
44NME11.14690599
45IRAK21.14482907
46MAP3K91.14259887
47STK38L1.08549161
48BLK1.08107524
49TXK1.06363898
50PIK3CG1.06112625
51CAMKK21.04324291
52ARAF1.03447022
53STK30.99784384
54OBSCN0.98649478
55MST1R0.95895389
56PTK20.95325842
57MAP3K130.94493215
58SCYL20.94246744
59BMX0.91766534
60TGFBR20.89231890
61CSF1R0.85507309
62MOS0.85001213
63PKN10.84938039
64SGK20.84564288
65ABL20.84401924
66YES10.84066928
67EIF2AK20.83691920
68PDGFRA0.81458169
69TEC0.80536689
70MAPK110.80144277
71ZAK0.78486651
72PDK20.76907459
73CCNB10.75758969
74CDK120.74920914
75PLK30.72823854
76RAF10.70818875
77FER0.70477618
78ADRBK20.70419969
79GRK50.70408775
80MAPKAPK20.70058944
81MAPK120.69784107
82MAPK70.69145588
83EPHB10.68839270
84SGK30.67627179
85NEK90.67363037
86BMPR20.67135790
87MAP3K110.64338636
88CSK0.63797547
89RIPK10.62764320
90MUSK0.58519261
91NEK60.57371769
92KIT0.56078352
93PRKCH0.54719630
94BRSK10.53663528
95MAP3K50.52744421
96SYK0.52508878
97ERBB40.52177096
98ROCK10.49995243
99DDR20.49834474
100JAK20.49344862
101KSR10.48511511
102ZAP700.47078382
103MAP3K120.46393558
104CDC42BPA0.45550032
105EPHA20.45495005
106MATK0.45132233
107CAMK2G0.44544925
108PDPK10.42293520
109MAP3K60.41581586
110PRKCD0.41191049
111HCK0.40848754
112TAOK20.40574587
113PRKD10.40270149
114PAK40.40146137
115PAK20.39575879
116MAP3K10.39335145
117PRKCI0.38598351
118DMPK0.38158002
119CLK10.37512283
120PAK60.37511761
121DAPK30.37029426
122PRKCZ0.36586390
123FGFR30.36078155
124FRK0.35299285
125MAPK40.35072862
126GSK3A0.35052917
127EPHA30.34489314
128PDK10.34266553
129ADRBK10.32483039
130SGK2230.31686216
131SGK4940.31686216
132MAP4K10.31605921
133SIK20.31361471
134MAP2K30.31199252
135PDGFRB0.30997169
136PRKACG0.30342436
137ABL10.29751070
138TAOK10.29581216
139MAPK30.28453785
140TSSK60.26885921
141EGFR0.26398231
142MAP2K10.25944979

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.50828489
2Graft-versus-host disease_Homo sapiens_hsa053322.23600900
3Leishmaniasis_Homo sapiens_hsa051402.13349651
4Rheumatoid arthritis_Homo sapiens_hsa053232.13130380
5Phototransduction_Homo sapiens_hsa0474410.8204090
6Legionellosis_Homo sapiens_hsa051341.97845259
7NOD-like receptor signaling pathway_Homo sapiens_hsa046211.93866775
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.91520757
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.90102131
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77185661
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.69673417
12Allograft rejection_Homo sapiens_hsa053301.64685780
13Tuberculosis_Homo sapiens_hsa051521.61893492
14TNF signaling pathway_Homo sapiens_hsa046681.59531655
15Osteoclast differentiation_Homo sapiens_hsa043801.45573588
16Type I diabetes mellitus_Homo sapiens_hsa049401.45358491
17Malaria_Homo sapiens_hsa051441.41174198
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40986026
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37272300
20Pertussis_Homo sapiens_hsa051331.36234432
21Salmonella infection_Homo sapiens_hsa051321.31906556
22Synaptic vesicle cycle_Homo sapiens_hsa047211.28898854
23Influenza A_Homo sapiens_hsa051641.27899234
24Phagosome_Homo sapiens_hsa041451.27292474
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23985543
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.23622315
27Measles_Homo sapiens_hsa051621.18835305
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13824714
29Toxoplasmosis_Homo sapiens_hsa051451.06773106
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06303157
31Collecting duct acid secretion_Homo sapiens_hsa049661.05890268
32Staphylococcus aureus infection_Homo sapiens_hsa051501.04010285
33Apoptosis_Homo sapiens_hsa042101.03866949
34Bladder cancer_Homo sapiens_hsa052191.02956089
35Chemokine signaling pathway_Homo sapiens_hsa040621.01710858
36Regulation of autophagy_Homo sapiens_hsa041401.01544289
37Asthma_Homo sapiens_hsa053100.98582421
38Lysosome_Homo sapiens_hsa041420.98156892
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91124452
40Herpes simplex infection_Homo sapiens_hsa051680.90236171
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87769795
42Circadian rhythm_Homo sapiens_hsa047100.85837101
43African trypanosomiasis_Homo sapiens_hsa051430.84528240
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83672593
45Olfactory transduction_Homo sapiens_hsa047400.82922099
46Hepatitis B_Homo sapiens_hsa051610.80462504
47Sphingolipid signaling pathway_Homo sapiens_hsa040710.80167948
48Viral myocarditis_Homo sapiens_hsa054160.79484438
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.78094622
50Dorso-ventral axis formation_Homo sapiens_hsa043200.75871224
51Hematopoietic cell lineage_Homo sapiens_hsa046400.75550337
52Shigellosis_Homo sapiens_hsa051310.75342107
53Amoebiasis_Homo sapiens_hsa051460.75327343
54HIF-1 signaling pathway_Homo sapiens_hsa040660.72394991
55Sulfur metabolism_Homo sapiens_hsa009200.71398772
56Fructose and mannose metabolism_Homo sapiens_hsa000510.67163743
57Hepatitis C_Homo sapiens_hsa051600.66362144
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65237496
59B cell receptor signaling pathway_Homo sapiens_hsa046620.64037162
60Epstein-Barr virus infection_Homo sapiens_hsa051690.63217519
61Autoimmune thyroid disease_Homo sapiens_hsa053200.63168801
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62755544
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62661060
64Antigen processing and presentation_Homo sapiens_hsa046120.62453214
65Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61612727
66Galactose metabolism_Homo sapiens_hsa000520.60816504
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60786474
68Mineral absorption_Homo sapiens_hsa049780.59898566
69Prolactin signaling pathway_Homo sapiens_hsa049170.59829268
70Focal adhesion_Homo sapiens_hsa045100.53540530
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52048161
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.51959345
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.51338424
74FoxO signaling pathway_Homo sapiens_hsa040680.51013049
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49099365
76Insulin resistance_Homo sapiens_hsa049310.47879239
77Platelet activation_Homo sapiens_hsa046110.44780004
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43735287
79p53 signaling pathway_Homo sapiens_hsa041150.43487760
80Serotonergic synapse_Homo sapiens_hsa047260.41791420
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41540999
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40754154
83Chronic myeloid leukemia_Homo sapiens_hsa052200.39147987
84Acute myeloid leukemia_Homo sapiens_hsa052210.37862418
85Type II diabetes mellitus_Homo sapiens_hsa049300.37570379
86Cholinergic synapse_Homo sapiens_hsa047250.37431908
87Dilated cardiomyopathy_Homo sapiens_hsa054140.36619455
88MAPK signaling pathway_Homo sapiens_hsa040100.36532130
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.35590957
90ErbB signaling pathway_Homo sapiens_hsa040120.34900259
91Vibrio cholerae infection_Homo sapiens_hsa051100.33263367
92Small cell lung cancer_Homo sapiens_hsa052220.32260213
93ECM-receptor interaction_Homo sapiens_hsa045120.32084975
94mTOR signaling pathway_Homo sapiens_hsa041500.31473347
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31371204
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30373654
97Prion diseases_Homo sapiens_hsa050200.30146815
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29380568
99Pancreatic cancer_Homo sapiens_hsa052120.28695529
100T cell receptor signaling pathway_Homo sapiens_hsa046600.27931008
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27883605
102GABAergic synapse_Homo sapiens_hsa047270.27016271
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.26919532
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26857131
105Inositol phosphate metabolism_Homo sapiens_hsa005620.26235968
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26002960
107Oxytocin signaling pathway_Homo sapiens_hsa049210.25969443
108Proteoglycans in cancer_Homo sapiens_hsa052050.24435633
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24378546
110VEGF signaling pathway_Homo sapiens_hsa043700.23988245
111Sphingolipid metabolism_Homo sapiens_hsa006000.21886543
112HTLV-I infection_Homo sapiens_hsa051660.21586030
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21221598
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21097055
115Viral carcinogenesis_Homo sapiens_hsa052030.20864737
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20776696
117Endocytosis_Homo sapiens_hsa041440.20239778
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19789348
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.17814312

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »