RABGGTB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the beta-subunit of the enzyme Rab geranylgeranyl-transferase (RabGGTase), which belongs to the protein prenyltransferase family. RabGGTase catalyzes the post-translational addition of geranylgeranyl groups to C-terminal cysteine residues of Rab GTPases. Three small nucleolar RNA genes are present in the intronic regions of this gene. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome organization (GO:0034723)7.33047840
2DNA replication-dependent nucleosome assembly (GO:0006335)7.33047840
3regulation of somitogenesis (GO:0014807)6.39278410
4regulation of centriole replication (GO:0046599)5.91889046
5maturation of SSU-rRNA (GO:0030490)5.49802369
6viral transcription (GO:0019083)5.04357151
7translational termination (GO:0006415)5.03737160
8cAMP catabolic process (GO:0006198)5.01431640
9regulation of relaxation of muscle (GO:1901077)5.00328501
10pericardium development (GO:0060039)4.86173437
11monoubiquitinated protein deubiquitination (GO:0035520)4.79882246
12regulation of centrosome cycle (GO:0046605)4.76818014
13formation of translation preinitiation complex (GO:0001731)4.74142694
14translational initiation (GO:0006413)4.73884016
15folic acid-containing compound biosynthetic process (GO:0009396)4.72281724
16homocysteine metabolic process (GO:0050667)4.61364742
17positive regulation of odontogenesis (GO:0042482)4.58738616
18nucleobase biosynthetic process (GO:0046112)4.57541344
19replicative senescence (GO:0090399)4.54130810
20ribosomal large subunit biogenesis (GO:0042273)4.52150818
21regulation of cardiac muscle cell contraction (GO:0086004)4.47309722
22purine nucleobase biosynthetic process (GO:0009113)4.43359971
23translational elongation (GO:0006414)4.36316089
24ribosomal small subunit biogenesis (GO:0042274)4.33689448
25cyclic nucleotide catabolic process (GO:0009214)4.30860527
26adrenergic receptor signaling pathway (GO:0071875)4.29897959
27cellular response to epinephrine stimulus (GO:0071872)4.28720424
28hepatocyte differentiation (GO:0070365)4.28280417
29establishment of protein localization to mitochondrial membrane (GO:0090151)4.19950633
30chromatin remodeling at centromere (GO:0031055)4.19317050
31positive regulation of RNA splicing (GO:0033120)4.17901682
32CENP-A containing nucleosome assembly (GO:0034080)4.16367300
33negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.15589084
34pathway-restricted SMAD protein phosphorylation (GO:0060389)4.14486787
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.14244135
36positive regulation of p38MAPK cascade (GO:1900745)4.14093511
37DNA replication initiation (GO:0006270)4.13257848
38regulation of centrosome duplication (GO:0010824)4.10032656
39cotranslational protein targeting to membrane (GO:0006613)4.08976884
40protein localization to kinetochore (GO:0034501)4.07716852
41protein targeting to ER (GO:0045047)4.07014108
42regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.05424356
43spliceosomal snRNP assembly (GO:0000387)4.02892771
44regulation of actin filament-based movement (GO:1903115)4.01142696
45atrioventricular valve morphogenesis (GO:0003181)3.99572026
46dorsal/ventral axis specification (GO:0009950)3.99319305
47nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.98725441
48pore complex assembly (GO:0046931)3.98608692
49cellular protein complex disassembly (GO:0043624)3.98525931
50ribosome assembly (GO:0042255)3.97705620
51DNA unwinding involved in DNA replication (GO:0006268)3.97094563
52establishment of protein localization to endoplasmic reticulum (GO:0072599)3.92709345
53IMP biosynthetic process (GO:0006188)3.88911099
54response to epinephrine (GO:0071871)3.86960484
55ribonucleoprotein complex biogenesis (GO:0022613)3.83950217
56nuclear pore organization (GO:0006999)3.83804354
57ribosomal small subunit assembly (GO:0000028)3.83226741
58citrulline biosynthetic process (GO:0019240)3.82708171
59protein localization to endoplasmic reticulum (GO:0070972)3.80242111
60mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.79470258
61folic acid metabolic process (GO:0046655)3.78932988
62positive regulation of heart rate (GO:0010460)3.78822074
63rRNA processing (GO:0006364)3.75086079
64negative regulation of DNA repair (GO:0045738)3.73640241
65DNA strand elongation involved in DNA replication (GO:0006271)3.73328233
66midgut development (GO:0007494)3.72948609
67viral life cycle (GO:0019058)3.72079370
68mitotic metaphase plate congression (GO:0007080)3.71851926
69nuclear pore complex assembly (GO:0051292)3.71588006
70urea cycle (GO:0000050)3.69180110
71nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.68981641
72transcription elongation from RNA polymerase I promoter (GO:0006362)3.67144064
73mitotic nuclear envelope disassembly (GO:0007077)3.62927711
74rRNA metabolic process (GO:0016072)3.59242093
75translation (GO:0006412)3.58229557
76glycine metabolic process (GO:0006544)3.55345256
77DNA strand elongation (GO:0022616)3.54147514
78post-anal tail morphogenesis (GO:0036342)3.53895421
79protein complex disassembly (GO:0043241)3.48065072
80ribosome biogenesis (GO:0042254)3.46869046
81DNA replication-independent nucleosome organization (GO:0034724)3.46369392
82DNA replication-independent nucleosome assembly (GO:0006336)3.46369392
83regulation of cell cycle checkpoint (GO:1901976)3.42980612
84DNA replication checkpoint (GO:0000076)3.42443899
85regulation of cell communication by electrical coupling (GO:0010649)3.41116455
86negative regulation of hormone biosynthetic process (GO:0032353)3.41080955
87regulation of gene silencing by RNA (GO:0060966)3.40658794
88regulation of posttranscriptional gene silencing (GO:0060147)3.40658794
89regulation of gene silencing by miRNA (GO:0060964)3.40658794
90histone mRNA metabolic process (GO:0008334)3.40126378
91nuclear-transcribed mRNA catabolic process (GO:0000956)3.37104895
92nuclear envelope disassembly (GO:0051081)3.36576034
93membrane disassembly (GO:0030397)3.36576034
94macromolecular complex disassembly (GO:0032984)3.35844585
95histone exchange (GO:0043486)3.34862665
96telomere maintenance via semi-conservative replication (GO:0032201)3.33719845
97negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.33492328
98positive regulation of osteoblast proliferation (GO:0033690)3.31638576
99negative regulation of peptidyl-serine phosphorylation (GO:0033137)3.31131361
100IMP metabolic process (GO:0046040)3.30317369
101viral mRNA export from host cell nucleus (GO:0046784)3.29906092
102iron ion import (GO:0097286)3.28706994
103metaphase plate congression (GO:0051310)3.27556525
104chaperone-mediated protein complex assembly (GO:0051131)3.27115089
105ATP synthesis coupled proton transport (GO:0015986)3.26902882
106energy coupled proton transport, down electrochemical gradient (GO:0015985)3.26902882
107urea metabolic process (GO:0019627)3.26516410
108membrane protein ectodomain proteolysis (GO:0006509)3.25876551
109sulfation (GO:0051923)3.21463442
110glutamine metabolic process (GO:0006541)3.19655171
111histone-serine phosphorylation (GO:0035404)3.17924382
112regulation of translational fidelity (GO:0006450)3.17867874
113regulation of translational termination (GO:0006449)3.17544727
114embryonic process involved in female pregnancy (GO:0060136)3.16155606
115DNA integration (GO:0015074)3.15647011
116mRNA catabolic process (GO:0006402)3.14928297
117mRNA cleavage (GO:0006379)3.14719319
118pteridine-containing compound biosynthetic process (GO:0042559)3.14535686
119negative regulation of hormone metabolic process (GO:0032351)3.12668088
120Rap protein signal transduction (GO:0032486)3.12256623
121tetrahydrofolate metabolic process (GO:0046653)3.12061606
122protein localization to chromosome, centromeric region (GO:0071459)3.11260909
123trophoblast giant cell differentiation (GO:0060707)3.07834088
124cAMP metabolic process (GO:0046058)3.07357435
125regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.06018917
126eyelid development in camera-type eye (GO:0061029)3.05598140
127negative regulation of translational initiation (GO:0045947)3.04090350
128RNA catabolic process (GO:0006401)3.03527986
129regulation of translational initiation (GO:0006446)3.02768141
130tRNA aminoacylation for protein translation (GO:0006418)3.02604424
131positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.01812048
132cellular component biogenesis (GO:0044085)3.01791183
133chromatin assembly or disassembly (GO:0006333)3.00662559
134establishment of endothelial barrier (GO:0061028)2.99277778
135regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.99145707
136regulation of spindle organization (GO:0090224)2.96599183
137negative regulation of gluconeogenesis (GO:0045721)2.95314398
138response to food (GO:0032094)2.95181001
139morphogenesis of an epithelial sheet (GO:0002011)2.93390926
140regulation of mitotic spindle organization (GO:0060236)2.92717416
141protein K11-linked deubiquitination (GO:0035871)2.92118551
142regulation of mitochondrial translation (GO:0070129)2.90675405
143folic acid-containing compound metabolic process (GO:0006760)2.90566729
144amino acid activation (GO:0043038)2.90218888
145tRNA aminoacylation (GO:0043039)2.90218888
146spliceosomal complex assembly (GO:0000245)2.90157525
147mitotic sister chromatid segregation (GO:0000070)2.88657979
148telomere maintenance via recombination (GO:0000722)2.88208137
149peptidyl-arginine omega-N-methylation (GO:0035247)2.86438106
150hematopoietic stem cell proliferation (GO:0071425)2.84333296
151mitotic recombination (GO:0006312)2.82404271
152somatic hypermutation of immunoglobulin genes (GO:0016446)2.82352683
153somatic diversification of immune receptors via somatic mutation (GO:0002566)2.82352683
154nucleotide-excision repair, DNA gap filling (GO:0006297)2.82088857
155positive regulation of mitotic sister chromatid separation (GO:1901970)2.81792939
156positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.81792939
157positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.81792939
158negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.81660586
159regulation of DNA damage checkpoint (GO:2000001)2.80922306
160cullin deneddylation (GO:0010388)2.80032499
161nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.79616004
162regulation of helicase activity (GO:0051095)2.79236660
163sister chromatid segregation (GO:0000819)2.78067090
164transcription elongation from RNA polymerase III promoter (GO:0006385)2.77369481
165regulation of p38MAPK cascade (GO:1900744)2.76989384
166termination of RNA polymerase I transcription (GO:0006363)2.76773335
167negative regulation of cardiac muscle tissue development (GO:0055026)2.75672372
168negative regulation of vascular permeability (GO:0043116)2.75067575
169retina vasculature morphogenesis in camera-type eye (GO:0061299)2.74588312
170endocardial cushion morphogenesis (GO:0003203)2.73689546
171cardiac epithelial to mesenchymal transition (GO:0060317)2.72851476
172regulation of DNA endoreduplication (GO:0032875)2.72843093
173nitrogen cycle metabolic process (GO:0071941)2.71605613
174positive regulation of vascular permeability (GO:0043117)2.70583075
175negative regulation of RNA splicing (GO:0033119)2.69814250
176response to growth hormone (GO:0060416)2.69613594
177cytokine production involved in immune response (GO:0002367)2.69518436
178positive regulation of DNA-templated transcription, elongation (GO:0032786)2.67620040
179transcription initiation from RNA polymerase I promoter (GO:0006361)2.64992735
180regulation of glucocorticoid metabolic process (GO:0031943)2.64590270
181lymphangiogenesis (GO:0001946)2.63877056
182protein destabilization (GO:0031648)2.61720858
183ER overload response (GO:0006983)2.58514667
184histone mRNA catabolic process (GO:0071044)2.57091081
185response to dexamethasone (GO:0071548)2.56173013
186regulation of histone H3-K27 methylation (GO:0061085)2.54928602
187citrulline metabolic process (GO:0000052)2.53885695
188negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.52921005
189epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.52755141

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.53725743
2E2F7_22180533_ChIP-Seq_HELA_Human6.70217358
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.54796153
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.52807531
5GATA1_22025678_ChIP-Seq_K562_Human3.72310309
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.56668380
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.37541522
8STAT6_21828071_ChIP-Seq_BEAS2B_Human3.34095693
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.11302639
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.11126169
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.00938366
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90355138
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.87219482
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.74494160
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.71322833
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.70232655
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65460518
18HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.62222493
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.57369945
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.55878008
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52485197
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41861643
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.33093022
24ESR1_15608294_ChIP-ChIP_MCF-7_Human2.25178996
25ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.23716189
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.19858639
27* XRN2_22483619_ChIP-Seq_HELA_Human2.17982786
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.16803276
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.15535022
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.13816620
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12106163
32* VDR_23849224_ChIP-Seq_CD4+_Human2.05696911
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.03510951
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00587378
35AR_21909140_ChIP-Seq_LNCAP_Human1.98612171
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88351203
37* ELK1_19687146_ChIP-ChIP_HELA_Human1.87026311
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85922250
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82104210
40TTF2_22483619_ChIP-Seq_HELA_Human1.81951492
41EWS_26573619_Chip-Seq_HEK293_Human1.78929405
42* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78777044
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.78016902
44DCP1A_22483619_ChIP-Seq_HELA_Human1.76912434
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76357352
46PKCTHETA_26484144_Chip-Seq_BREAST_Human1.75972883
47FOXP3_21729870_ChIP-Seq_TREG_Human1.75235782
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71935153
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.69299545
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.68076860
51FUS_26573619_Chip-Seq_HEK293_Human1.67048623
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.67039497
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65962149
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59577782
55CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.58738130
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57824971
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48708102
58TCF3_18692474_ChIP-Seq_MEFs_Mouse1.47798543
59NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.45550709
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44758433
61* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44540955
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44017396
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42004167
64TP53_16413492_ChIP-PET_HCT116_Human1.41532349
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38853456
66EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38423893
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37979510
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37867449
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35371947
70FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.34562201
71GABP_19822575_ChIP-Seq_HepG2_Human1.32199797
72SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.31146736
73LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31103420
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31050702
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30762852
76TCF3_18692474_ChIP-Seq_MESCs_Mouse1.30682614
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30084458
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28032805
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27638001
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.25755535
81FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24584627
82* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24397992
83MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23255526
84NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.23174030
85SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22026368
86SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22026368
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21422297
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21364806
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20803369
90UBF1/2_26484160_Chip-Seq_HMECs_Human1.19984355
91SRF_21415370_ChIP-Seq_HL-1_Mouse1.17540066
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16701432
93MYC_18940864_ChIP-ChIP_HL60_Human1.15241041
94* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12162808
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10008401
96* KDM5A_27292631_Chip-Seq_BREAST_Human1.09803715
97* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08649088
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05353708
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04932696
100YY1_21170310_ChIP-Seq_MESCs_Mouse1.04613981
101EGR1_19374776_ChIP-ChIP_THP-1_Human1.04157890
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03876793
103* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01871808
104* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01638561
105TFEB_21752829_ChIP-Seq_HELA_Human1.01617232
106FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01560965
107IRF1_19129219_ChIP-ChIP_H3396_Human1.01404956
108FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00549135
109SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00353267
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00144788
111SOX2_16153702_ChIP-ChIP_HESCs_Human0.99328275
112ZNF263_19887448_ChIP-Seq_K562_Human0.98958073
113NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98390475
114NANOG_16153702_ChIP-ChIP_HESCs_Human0.97933071
115CHD1_26751641_Chip-Seq_LNCaP_Human0.97737931
116AR_21572438_ChIP-Seq_LNCaP_Human0.97543645
117* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96295963
118NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95553051
119GATA6_25053715_ChIP-Seq_YYC3_Human0.95416328
120ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95148461
121SOX2_18692474_ChIP-Seq_MESCs_Mouse0.95143704
122* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93070106
123CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92918525
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92531597
125TAF15_26573619_Chip-Seq_HEK293_Human0.91878910
126AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91825893
127NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91712621
128NANOG_21062744_ChIP-ChIP_HESCs_Human0.91481772
129SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90973709
130AHR_22903824_ChIP-Seq_MCF-7_Human0.90788123
131CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90510512
132ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87953341
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87700176
134BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86979799
135NOTCH1_21737748_ChIP-Seq_TLL_Human0.86602534
136CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86378730
137MYB_26560356_Chip-Seq_TH1_Human0.86260829
138ESR1_20079471_ChIP-ChIP_T-47D_Human0.84838270
139VDR_21846776_ChIP-Seq_THP-1_Human0.84465707
140GATA1_26923725_Chip-Seq_HPCs_Mouse0.84349800
141SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.84146729
142* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83956257
143NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83655154
144FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.82035424
145RUNX1_27514584_Chip-Seq_MCF-7_Human0.78094797
146ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77464214
147POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76904269
148GF1B_26923725_Chip-Seq_HPCs_Mouse0.74899294
149TP53_18474530_ChIP-ChIP_U2OS_Human0.74723690
150E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.73945396
151CJUN_26792858_Chip-Seq_BT549_Human0.73353103
152BRD4_25478319_ChIP-Seq_HGPS_Human0.73029210
153ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.69106371
154TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.68737511
155RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.68456944
156MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.68329051
157EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.68254579
158AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.67823541
159* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.67756928

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.65623419
2MP0004957_abnormal_blastocyst_morpholog4.38726150
3MP0010094_abnormal_chromosome_stability4.00511661
4MP0003693_abnormal_embryo_hatching3.71787039
5MP0002009_preneoplasia3.71769874
6MP0008057_abnormal_DNA_replication3.64978401
7MP0003111_abnormal_nucleus_morphology3.56772138
8MP0009379_abnormal_foot_pigmentation3.36077956
9MP0003183_abnormal_peptide_metabolism3.31943748
10MP0003077_abnormal_cell_cycle3.14273060
11MP0003123_paternal_imprinting2.83181499
12MP0005085_abnormal_gallbladder_physiolo2.56276313
13MP0008932_abnormal_embryonic_tissue2.51785808
14MP0005275_abnormal_skin_tensile2.46208384
15MP0000569_abnormal_digit_pigmentation2.25059980
16MP0008438_abnormal_cutaneous_collagen2.21808331
17MP0008058_abnormal_DNA_repair2.21595843
18MP0002396_abnormal_hematopoietic_system2.14429806
19MP0010352_gastrointestinal_tract_polyps2.12874768
20MP0001730_embryonic_growth_arrest2.04083808
21MP0010307_abnormal_tumor_latency2.02313349
22MP0002160_abnormal_reproductive_system2.00167842
23MP0003941_abnormal_skin_development1.98765566
24MP0003705_abnormal_hypodermis_morpholog1.96317857
25MP0000350_abnormal_cell_proliferation1.84831322
26MP0003718_maternal_effect1.75877344
27MP0005083_abnormal_biliary_tract1.73651144
28MP0003786_premature_aging1.73120746
29MP0006036_abnormal_mitochondrial_physio1.67383867
30MP0001672_abnormal_embryogenesis/_devel1.65652239
31MP0005380_embryogenesis_phenotype1.65652239
32MP0001697_abnormal_embryo_size1.60890578
33MP0000003_abnormal_adipose_tissue1.60566988
34MP0004808_abnormal_hematopoietic_stem1.55884501
35MP0002139_abnormal_hepatobiliary_system1.51090055
36MP0003656_abnormal_erythrocyte_physiolo1.50824583
37MP0002080_prenatal_lethality1.49822240
38MP0004197_abnormal_fetal_growth/weight/1.48992895
39MP0002088_abnormal_embryonic_growth/wei1.47929122
40MP0003984_embryonic_growth_retardation1.47929011
41MP0005379_endocrine/exocrine_gland_phen1.47287707
42MP0005360_urolithiasis1.46921115
43MP0008007_abnormal_cellular_replicative1.46032568
44MP0002086_abnormal_extraembryonic_tissu1.45665586
45MP0006035_abnormal_mitochondrial_morpho1.43155307
46MP0006138_congestive_heart_failure1.41658745
47MP0010234_abnormal_vibrissa_follicle1.41578919
48MP0005365_abnormal_bile_salt1.41201500
49MP0005266_abnormal_metabolism1.40665133
50MP0003567_abnormal_fetal_cardiomyocyte1.35999517
51MP0000750_abnormal_muscle_regeneration1.35956345
52MP0001661_extended_life_span1.34749028
53MP0002084_abnormal_developmental_patter1.34163036
54MP0002877_abnormal_melanocyte_morpholog1.33234118
55MP0002085_abnormal_embryonic_tissue1.32322498
56MP0002166_altered_tumor_susceptibility1.31569131
57MP0002089_abnormal_postnatal_growth/wei1.30030744
58MP0000733_abnormal_muscle_development1.28894503
59MP0003136_yellow_coat_color1.23851910
60MP0003828_pulmonary_edema1.19709210
61MP0005171_absent_coat_pigmentation1.18338690
62MP0001293_anophthalmia1.18073718
63MP0004133_heterotaxia1.16530807
64MP0002269_muscular_atrophy1.16269306
65MP0004084_abnormal_cardiac_muscle1.14719255
66MP0006054_spinal_hemorrhage1.14388250
67MP0009053_abnormal_anal_canal1.12758962
68MP0005220_abnormal_exocrine_pancreas1.12449074
69MP0003959_abnormal_lean_body1.12202923
70MP0000013_abnormal_adipose_tissue1.09675796
71MP0000371_diluted_coat_color1.09070878
72MP0000358_abnormal_cell_content/1.07717597
73MP0004272_abnormal_basement_membrane1.05399409
74MP0003890_abnormal_embryonic-extraembry1.04193572
75MP0002138_abnormal_hepatobiliary_system1.03960974
76MP0005332_abnormal_amino_acid1.03897008
77MP0000747_muscle_weakness1.03478292
78MP0008875_abnormal_xenobiotic_pharmacok1.01126217
79MP0003937_abnormal_limbs/digits/tail_de0.99826680
80MP0009697_abnormal_copulation0.99418887
81MP0005501_abnormal_skin_physiology0.98557529
82MP0004215_abnormal_myocardial_fiber0.98020050
83MP0002060_abnormal_skin_morphology0.97872386
84MP0004233_abnormal_muscle_weight0.97044190
85MP0002971_abnormal_brown_adipose0.96716432
86MP0003252_abnormal_bile_duct0.95470343
87MP0001348_abnormal_lacrimal_gland0.94982204
88MP0003121_genomic_imprinting0.94874974
89MP0002837_dystrophic_cardiac_calcinosis0.93490540
90MP0002928_abnormal_bile_duct0.92838944
91MP0003950_abnormal_plasma_membrane0.92053399
92MP0005408_hypopigmentation0.90994407
93MP0002332_abnormal_exercise_endurance0.90894386
94MP0001544_abnormal_cardiovascular_syste0.90299168
95MP0005385_cardiovascular_system_phenoty0.90299168
96MP0003119_abnormal_digestive_system0.90094835
97MP0009250_abnormal_appendicular_skeleto0.88812091
98MP0000613_abnormal_salivary_gland0.88267263
99MP0000566_synostosis0.88091704
100MP0000313_abnormal_cell_death0.87868638
101MP0004087_abnormal_muscle_fiber0.87039237
102MP0001879_abnormal_lymphatic_vessel0.83772857
103MP0005389_reproductive_system_phenotype0.83260454
104MP0009672_abnormal_birth_weight0.83161620
105MP0005503_abnormal_tendon_morphology0.82463035
106MP0003186_abnormal_redox_activity0.82102056
107MP0002111_abnormal_tail_morphology0.81739435
108MP0009115_abnormal_fat_cell0.80086510
109MP0001145_abnormal_male_reproductive0.80053603
110MP0002006_tumorigenesis0.78739957
111MP0003221_abnormal_cardiomyocyte_apopto0.78427819
112MP0004185_abnormal_adipocyte_glucose0.78413952
113MP0002796_impaired_skin_barrier0.77086184
114MP0002019_abnormal_tumor_incidence0.77062753
115MP0005409_darkened_coat_color0.77026432
116MP0002972_abnormal_cardiac_muscle0.75512736
117MP0004381_abnormal_hair_follicle0.75467972
118MP0001529_abnormal_vocalization0.74959353
119MP0000428_abnormal_craniofacial_morphol0.74606389
120MP0005375_adipose_tissue_phenotype0.74192121
121MP0005076_abnormal_cell_differentiation0.74165558
122MP0010678_abnormal_skin_adnexa0.73971862
123MP0002932_abnormal_joint_morphology0.73804867
124MP0005647_abnormal_sex_gland0.73083503
125MP0001243_abnormal_dermal_layer0.71450439
126MP0000609_abnormal_liver_physiology0.71373899
127MP0005330_cardiomyopathy0.70990361
128MP0003868_abnormal_feces_composition0.70897821
129MP0005023_abnormal_wound_healing0.70309206
130MP0002106_abnormal_muscle_physiology0.69882505
131MP0008961_abnormal_basal_metabolism0.69805209
132MP0001915_intracranial_hemorrhage0.69538833
133MP0004147_increased_porphyrin_level0.69485169
134MP0000751_myopathy0.69440814
135MP0004484_altered_response_of0.69334891
136MP0008775_abnormal_heart_ventricle0.69310709
137MP0002638_abnormal_pupillary_reflex0.69171549
138MP0010630_abnormal_cardiac_muscle0.68068106
139MP0002108_abnormal_muscle_morphology0.67797810
140MP0005376_homeostasis/metabolism_phenot0.67758535
141MP0002697_abnormal_eye_size0.66308285
142MP0005334_abnormal_fat_pad0.65664870
143MP0002127_abnormal_cardiovascular_syste0.64195396
144MP0002210_abnormal_sex_determination0.64112040
145MP0004085_abnormal_heartbeat0.63866967
146MP0000759_abnormal_skeletal_muscle0.63332128
147MP0000163_abnormal_cartilage_morphology0.63080389
148MP0002163_abnormal_gland_morphology0.62913839
149MP0008770_decreased_survivor_rate0.62809756
150MP0000598_abnormal_liver_morphology0.62672022
151MP0000653_abnormal_sex_gland0.62277627
152MP0000383_abnormal_hair_follicle0.59985772
153MP0004264_abnormal_extraembryonic_tissu0.59351564
154MP0005384_cellular_phenotype0.59179842

Predicted human phenotypes

RankGene SetZ-score
1Anomalous pulmonary venous return (HP:0010772)5.34976348
2Birth length less than 3rd percentile (HP:0003561)4.89338548
3Abnormality of the pulmonary veins (HP:0011718)4.68455467
4Fair hair (HP:0002286)4.39321399
5Abnormality of the nasal septum (HP:0000419)4.13048745
6Abnormal hemoglobin (HP:0011902)4.11422813
7Diastasis recti (HP:0001540)4.05827620
8Vertebral arch anomaly (HP:0008438)4.04405692
9Abnormality of the labia minora (HP:0012880)3.92178250
10Tongue fasciculations (HP:0001308)3.78596616
11Breast hypoplasia (HP:0003187)3.78213158
12Reticulocytopenia (HP:0001896)3.71758174
13Thoracolumbar scoliosis (HP:0002944)3.63619750
14Macrocytic anemia (HP:0001972)3.59150834
15Muscle fibrillation (HP:0010546)3.55175044
16Hypobetalipoproteinemia (HP:0003563)3.52790699
17Abnormality of cells of the erythroid lineage (HP:0012130)3.50423475
18Duplicated collecting system (HP:0000081)3.46578406
19Premature graying of hair (HP:0002216)3.43912737
20Hyperglycinemia (HP:0002154)3.35477790
21Generalized hypopigmentation of hair (HP:0011358)3.29474485
22Spastic diplegia (HP:0001264)3.28610857
23Broad ribs (HP:0000885)3.21386748
24Cerebral edema (HP:0002181)3.16628179
25Lip pit (HP:0100267)3.15963693
26J-shaped sella turcica (HP:0002680)3.15823622
27Abnormality of the lumbar spine (HP:0100712)3.12822955
28Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.07051870
29Aortic regurgitation (HP:0001659)3.06842023
30Abnormal number of erythroid precursors (HP:0012131)3.06033720
31Pallor (HP:0000980)3.05885390
32Abnormality of the odontoid process (HP:0003310)3.04619188
33Deformed sella turcica (HP:0002681)3.03212742
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.97297945
35Acute necrotizing encephalopathy (HP:0006965)2.96821841
36Abnormality of pyrimidine metabolism (HP:0004353)2.91092412
37Wide intermamillary distance (HP:0006610)2.89253534
38Flat acetabular roof (HP:0003180)2.86965186
39Increased CSF lactate (HP:0002490)2.86088773
40Increased hepatocellular lipid droplets (HP:0006565)2.85953030
41Increased connective tissue (HP:0009025)2.83581867
42Lipid accumulation in hepatocytes (HP:0006561)2.76815540
43Abnormal mitochondria in muscle tissue (HP:0008316)2.76015135
44Chromsome breakage (HP:0040012)2.74315905
45Impulsivity (HP:0100710)2.71541026
46Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.71305297
47Mitochondrial inheritance (HP:0001427)2.71237521
48Cerebellar dysplasia (HP:0007033)2.69018341
49Acute encephalopathy (HP:0006846)2.67818081
50Abnormality of the renal collecting system (HP:0004742)2.65981944
51Cerebral hypomyelination (HP:0006808)2.63087070
52Increased serum pyruvate (HP:0003542)2.62630517
53Abnormality of glycolysis (HP:0004366)2.62630517
54Ureteral duplication (HP:0000073)2.61716366
55Abnormality of the phalanges of the 2nd finger (HP:0009541)2.61133692
56Colon cancer (HP:0003003)2.59041019
57Oral leukoplakia (HP:0002745)2.58797076
58Ependymoma (HP:0002888)2.56251565
59Protrusio acetabuli (HP:0003179)2.55551764
60Abnormality of the sella turcica (HP:0002679)2.54728594
61Progressive macrocephaly (HP:0004481)2.51203228
62Rhabdomyosarcoma (HP:0002859)2.50039099
63Increased serum lactate (HP:0002151)2.45999568
64Abnormality of the preputium (HP:0100587)2.45419364
65Hepatocellular necrosis (HP:0001404)2.44389786
66Aplasia cutis congenita (HP:0001057)2.44146362
67Slow saccadic eye movements (HP:0000514)2.43136639
68Abnormality of ocular smooth pursuit (HP:0000617)2.40029384
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.39536214
70Decreased activity of mitochondrial respiratory chain (HP:0008972)2.39536214
71Blue irides (HP:0000635)2.39407547
72Vertebral fusion (HP:0002948)2.37483703
73Abnormality of serine family amino acid metabolism (HP:0010894)2.35592579
74Abnormality of glycine metabolism (HP:0010895)2.35592579
75Alkalosis (HP:0001948)2.35261966
76Hepatic necrosis (HP:0002605)2.35111173
77Abnormality of serum amino acid levels (HP:0003112)2.33750943
78Thickened calvaria (HP:0002684)2.33612356
79Prominent occiput (HP:0000269)2.33379034
80Abnormality of monocarboxylic acid metabolism (HP:0010996)2.31808283
81Abnormality of the pons (HP:0007361)2.31555314
82Intrahepatic cholestasis (HP:0001406)2.30581047
83Short chin (HP:0000331)2.30250522
84Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.29668618
85Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.29181287
86Absent radius (HP:0003974)2.28371149
87Selective tooth agenesis (HP:0001592)2.26124677
88Pathologic fracture (HP:0002756)2.25064526
89Thoracic kyphosis (HP:0002942)2.23318075
90Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.22776404
91Abnormality of chromosome stability (HP:0003220)2.21656672
92Abnormality of the 2nd finger (HP:0004100)2.21086783
93Lethargy (HP:0001254)2.20859658
94Carpal bone hypoplasia (HP:0001498)2.20011533
95Ankle contracture (HP:0006466)2.18858434
96CNS demyelination (HP:0007305)2.17649106
97Hypolipoproteinemia (HP:0010981)2.17522090
98Microvesicular hepatic steatosis (HP:0001414)2.16359132
99Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.15210049
100Partial agenesis of the corpus callosum (HP:0001338)2.15182826
101Abnormal pancreas size (HP:0012094)2.15094875
102Trismus (HP:0000211)2.14210789
103Angiofibromas (HP:0010615)2.12547176
104Adenoma sebaceum (HP:0009720)2.12547176
105Absent forearm bone (HP:0003953)2.12416813
106Aplasia involving forearm bones (HP:0009822)2.12416813
107Prominent nose (HP:0000448)2.12315161
108Emotional lability (HP:0000712)2.12143162
109Megaloblastic anemia (HP:0001889)2.11564461
110Periauricular skin pits (HP:0100277)2.09251870
111Preauricular pit (HP:0004467)2.09251870
112Myelomeningocele (HP:0002475)2.08482162
113Deep philtrum (HP:0002002)2.08053786
114Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.07414050
115Hyperammonemia (HP:0001987)2.06155312
116Agnosia (HP:0010524)2.06120817
117Hyperglycinuria (HP:0003108)2.03417887
118Neoplasm of the pancreas (HP:0002894)2.03045605
119Abnormality of methionine metabolism (HP:0010901)2.02574362
120Spinal cord lesions (HP:0100561)2.02468321
121Syringomyelia (HP:0003396)2.02468321
122Ectopic kidney (HP:0000086)2.02049774
123Mild short stature (HP:0003502)2.01628190
124Aplasia/Hypoplasia of the uvula (HP:0010293)2.00931123
1252-3 toe syndactyly (HP:0004691)2.00490722
126Impaired smooth pursuit (HP:0007772)1.99669922
127Abnormality of reticulocytes (HP:0004312)1.98294964
128Supernumerary spleens (HP:0009799)1.98256524
129Progressive muscle weakness (HP:0003323)1.98108144
130Skin pits (HP:0100276)1.97733209
131Abnormality of the phalanges of the 5th finger (HP:0004213)1.96501563
132Muscle fiber splitting (HP:0003555)1.96004789
133Lactic acidosis (HP:0003128)1.95563974
134Premature ovarian failure (HP:0008209)1.94586561
135Anal stenosis (HP:0002025)1.93806453
136Medulloblastoma (HP:0002885)1.93242302
137Rough bone trabeculation (HP:0100670)1.92818036
138Asymmetry of the thorax (HP:0001555)1.92392837
139Abnormal auditory evoked potentials (HP:0006958)1.91380119
140Paralysis (HP:0003470)1.91171162
141Genetic anticipation (HP:0003743)1.91138204
142Biliary tract neoplasm (HP:0100574)1.89336016
143Hypoglycemic coma (HP:0001325)1.89306966
144Abnormal trabecular bone morphology (HP:0100671)1.88836942
145Hypoplasia of the pons (HP:0012110)1.88715763
146Abnormality of the thoracic spine (HP:0100711)1.88658133
147Progressive external ophthalmoplegia (HP:0000590)1.88525236
148Urethral obstruction (HP:0000796)1.85981684
149Abnormality of alanine metabolism (HP:0010916)1.85598086
150Hyperalaninemia (HP:0003348)1.85598086
151Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85598086
152Abnormality of DNA repair (HP:0003254)1.85296149
1533-Methylglutaconic aciduria (HP:0003535)1.84323908
154Increased circulating renin level (HP:0000848)1.83361565
155Absent thumb (HP:0009777)1.82930974
156Abnormality of the intervertebral disk (HP:0005108)1.82707275
157Horseshoe kidney (HP:0000085)1.82341668
158Secondary amenorrhea (HP:0000869)1.82077490
159CNS hypomyelination (HP:0003429)1.80929182
160Exercise intolerance (HP:0003546)1.80866558
161Elbow flexion contracture (HP:0002987)1.80585634
162Fibular aplasia (HP:0002990)1.80153294
163Abnormality of the epiphyses of the hand (HP:0005924)1.79927307
164Abnormality of saccadic eye movements (HP:0000570)1.78963817
165Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.78275617
166Subacute progressive viral hepatitis (HP:0006572)1.78155707
167Leukodystrophy (HP:0002415)1.77895338
168Multiple enchondromatosis (HP:0005701)1.77008098
169Acute myeloid leukemia (HP:0004808)1.76986809
170Hemivertebrae (HP:0002937)1.76475672
171Respiratory difficulties (HP:0002880)1.76373988
172Respiratory failure (HP:0002878)1.76197602
173Delusions (HP:0000746)1.75876968
174Abnormality of homocysteine metabolism (HP:0010919)1.75300294
175Homocystinuria (HP:0002156)1.75300294
176Breast aplasia (HP:0100783)1.74139347
177Areflexia of lower limbs (HP:0002522)1.74080836
178Flared iliac wings (HP:0002869)1.72716260
179Facial hemangioma (HP:0000329)1.72682813
180Deep venous thrombosis (HP:0002625)1.72527151
181Decreased circulating renin level (HP:0003351)1.72405555
182Squamous cell carcinoma (HP:0002860)1.72320255
183Broad alveolar ridges (HP:0000187)1.71876699
184Aplasia/Hypoplasia of the scapulae (HP:0006713)1.70451738
185Hypoplastic scapulae (HP:0000882)1.70451738
186Sparse lateral eyebrow (HP:0005338)1.70056689
187Orthostatic hypotension (HP:0001278)1.69168722

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK16.70137145
2BLK6.69340728
3WEE14.83015772
4ZAK4.24689706
5BUB13.76315463
6VRK13.26308886
7WNK43.23927817
8EPHA23.09095769
9TSSK63.04243223
10CDC72.56808888
11NEK12.53772661
12STK392.41994547
13SRPK12.35718009
14EIF2AK32.02837305
15EIF2AK11.94517341
16NEK61.87093112
17MST1R1.85333560
18NME21.79626476
19PNCK1.75698562
20NEK21.67138710
21RPS6KB21.66722918
22TTK1.49318029
23MKNK21.45269055
24FLT31.44812415
25BRSK21.43184982
26PLK11.42614226
27AKT31.40015676
28OXSR11.39569557
29PLK31.38683257
30MKNK11.37887543
31PDK31.37652723
32PDK41.37652723
33BMPR1B1.34446957
34NME11.28654488
35RPS6KA51.27571519
36BCKDK1.26784077
37PKN21.26783502
38CDK71.26078881
39AURKA1.24838240
40TGFBR21.24415296
41CAMK1D1.18799786
42STK41.17029730
43SCYL21.15703087
44CHEK21.14863508
45AURKB1.13973014
46ACVR1B1.11128440
47MST41.09360758
48MAPK71.06071396
49PIM11.05961437
50NEK91.04272596
51CDK121.02617995
52MAP3K20.97815718
53INSRR0.97770457
54STK160.93372752
55ERBB40.92897258
56MAP2K30.91811158
57MAP3K80.91745671
58BMPR20.91227318
59STK38L0.87498582
60MET0.87185888
61PLK40.86618917
62PDK20.84728355
63MAPK120.83470519
64ATR0.83405361
65PASK0.82318842
66PRPF4B0.81881582
67PBK0.80315304
68CAMKK20.80204499
69CAMK40.78715774
70DAPK30.77682283
71MAP2K40.77058414
72CHEK10.75710733
73CSNK2A20.73331652
74MAP3K60.73286859
75WNK10.71825432
76TESK20.71142157
77CDK40.71047329
78RIPK10.70564250
79RAF10.69612811
80CAMK1G0.67787895
81LATS10.64008460
82MAP3K40.63090048
83TRPM70.58001003
84MAP3K140.57738585
85CDK80.56627927
86EIF2AK20.55680089
87MELK0.53919750
88ATM0.53739688
89MAP3K90.53520143
90STK30.53162900
91CDK20.51756533
92MAPK110.49218543
93PDGFRB0.48895799
94CSNK2A10.47448935
95STK110.47229986
96PKN10.46979276
97AKT20.46943195
98PRKCI0.45979552
99CSNK1D0.45787528
100SGK20.45052281
101RPS6KA60.44504753
102CCNB10.43390468
103SYK0.42132222
104YES10.41444280
105PAK40.41048498
106CDK10.40734376
107PAK10.40584091
108ADRBK20.40581900
109TEC0.40029212
110MAP3K100.39806764
111PRKAA10.38646203
112ICK0.38580513
113CSNK1E0.37101821
114BRD40.36628499
115OBSCN0.35606514
116PRKAA20.35218283
117FRK0.34763467
118DYRK30.34666207
119HIPK20.33736405
120GRK60.33603270
121IRAK30.33188214
122IKBKB0.32939156
123RPS6KL10.32854176
124RPS6KC10.32854176
125LATS20.32833115
126MAP3K30.32587031
127PDK10.31904205
128PAK20.31459460
129MAP3K50.29861012
130BRSK10.29492534
131MAP3K70.28998663
132TAOK30.28062836
133MAP3K110.27949041
134MAPK10.27871627
135CDK60.27312831
136AKT10.27290587
137MTOR0.27077448
138FGFR10.25403240
139STK240.24485104
140MAP3K120.24197885
141TGFBR10.23238099
142PIM20.21775251
143PLK20.21760171
144ALK0.21530546
145CDK90.20569884
146FER0.20524162
147RPS6KB10.20303349
148PRKDC0.20120402
149TTN0.19139200
150GRK70.18802658
151LRRK20.16362432

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.51895977
2Ribosome_Homo sapiens_hsa030103.84264581
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.55556424
4Mismatch repair_Homo sapiens_hsa034303.32610271
5DNA replication_Homo sapiens_hsa030303.19686145
6Proteasome_Homo sapiens_hsa030502.98412123
7RNA transport_Homo sapiens_hsa030132.78569704
8One carbon pool by folate_Homo sapiens_hsa006702.76440759
9RNA polymerase_Homo sapiens_hsa030202.64402848
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.48558140
11Spliceosome_Homo sapiens_hsa030402.40739168
12TGF-beta signaling pathway_Homo sapiens_hsa043502.18970013
13Nucleotide excision repair_Homo sapiens_hsa034202.06168489
14Alcoholism_Homo sapiens_hsa050341.93756984
15Homologous recombination_Homo sapiens_hsa034401.84191176
16Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.83015152
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.82199180
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.81830003
19Oxidative phosphorylation_Homo sapiens_hsa001901.80547898
20Pyrimidine metabolism_Homo sapiens_hsa002401.76706472
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.71646060
22Dorso-ventral axis formation_Homo sapiens_hsa043201.71056801
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.69128705
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.66721246
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64787007
26Cell cycle_Homo sapiens_hsa041101.62239824
27Parkinsons disease_Homo sapiens_hsa050121.59542461
28Biosynthesis of amino acids_Homo sapiens_hsa012301.59370900
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.50367876
30FoxO signaling pathway_Homo sapiens_hsa040681.42828133
31Carbon metabolism_Homo sapiens_hsa012001.42038413
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.35203500
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32500760
34p53 signaling pathway_Homo sapiens_hsa041151.29164769
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28398843
36Huntingtons disease_Homo sapiens_hsa050161.28239023
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.26932705
38Pyruvate metabolism_Homo sapiens_hsa006201.24134456
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22251816
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22082513
41Base excision repair_Homo sapiens_hsa034101.19714472
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17663053
43RNA degradation_Homo sapiens_hsa030181.17489666
44Fanconi anemia pathway_Homo sapiens_hsa034601.17235231
45Ovarian steroidogenesis_Homo sapiens_hsa049131.16791594
46Vitamin B6 metabolism_Homo sapiens_hsa007501.16028511
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.13134420
48mTOR signaling pathway_Homo sapiens_hsa041501.11383140
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09620922
50Non-homologous end-joining_Homo sapiens_hsa034501.07844156
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06582869
52Hedgehog signaling pathway_Homo sapiens_hsa043401.03301859
53Fatty acid degradation_Homo sapiens_hsa000711.02694680
54Viral carcinogenesis_Homo sapiens_hsa052031.02568025
55Fatty acid biosynthesis_Homo sapiens_hsa000611.01771827
56Pentose phosphate pathway_Homo sapiens_hsa000301.00927800
57Drug metabolism - other enzymes_Homo sapiens_hsa009831.00017903
58Alzheimers disease_Homo sapiens_hsa050100.96449984
59Circadian rhythm_Homo sapiens_hsa047100.95758865
60Dilated cardiomyopathy_Homo sapiens_hsa054140.95739561
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.95711167
62Propanoate metabolism_Homo sapiens_hsa006400.95353843
63Morphine addiction_Homo sapiens_hsa050320.94726829
64Folate biosynthesis_Homo sapiens_hsa007900.93046668
65Selenocompound metabolism_Homo sapiens_hsa004500.92123270
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91860927
67Phenylalanine metabolism_Homo sapiens_hsa003600.89641903
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89530294
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88987673
70Basal cell carcinoma_Homo sapiens_hsa052170.87671725
71TNF signaling pathway_Homo sapiens_hsa046680.86251696
72mRNA surveillance pathway_Homo sapiens_hsa030150.86232971
73Basal transcription factors_Homo sapiens_hsa030220.85752586
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84171064
75Purine metabolism_Homo sapiens_hsa002300.84116643
76Tyrosine metabolism_Homo sapiens_hsa003500.83333699
77Arginine biosynthesis_Homo sapiens_hsa002200.82548965
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81260233
79HTLV-I infection_Homo sapiens_hsa051660.81068531
80Nitrogen metabolism_Homo sapiens_hsa009100.78962427
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.75252765
82Taste transduction_Homo sapiens_hsa047420.75251588
83ABC transporters_Homo sapiens_hsa020100.74403813
84Fatty acid elongation_Homo sapiens_hsa000620.73845353
85Melanoma_Homo sapiens_hsa052180.73710515
86Fatty acid metabolism_Homo sapiens_hsa012120.72988052
87Butanoate metabolism_Homo sapiens_hsa006500.69341970
88Platelet activation_Homo sapiens_hsa046110.68526801
89Chronic myeloid leukemia_Homo sapiens_hsa052200.68191324
90Prostate cancer_Homo sapiens_hsa052150.67986923
91GnRH signaling pathway_Homo sapiens_hsa049120.67057098
92Insulin resistance_Homo sapiens_hsa049310.65979431
93Influenza A_Homo sapiens_hsa051640.65693960
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64170706
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62724927
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.62678926
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61267407
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61078592
99Glutathione metabolism_Homo sapiens_hsa004800.61035433
100B cell receptor signaling pathway_Homo sapiens_hsa046620.60838861
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60614187
102Non-small cell lung cancer_Homo sapiens_hsa052230.60209719
103Protein export_Homo sapiens_hsa030600.59428446
104Arginine and proline metabolism_Homo sapiens_hsa003300.59158087
105Pathways in cancer_Homo sapiens_hsa052000.57883379
106Metabolic pathways_Homo sapiens_hsa011000.57658243
107Epstein-Barr virus infection_Homo sapiens_hsa051690.57090656
108MAPK signaling pathway_Homo sapiens_hsa040100.56941422
109Tryptophan metabolism_Homo sapiens_hsa003800.56836608
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56126547
111Complement and coagulation cascades_Homo sapiens_hsa046100.55615628
112Oocyte meiosis_Homo sapiens_hsa041140.54867293
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53867491
114beta-Alanine metabolism_Homo sapiens_hsa004100.53184371
115Hippo signaling pathway_Homo sapiens_hsa043900.53181099
116Prolactin signaling pathway_Homo sapiens_hsa049170.53016492
117cAMP signaling pathway_Homo sapiens_hsa040240.50470526
118T cell receptor signaling pathway_Homo sapiens_hsa046600.49385198
119Peroxisome_Homo sapiens_hsa041460.47786846
120Apoptosis_Homo sapiens_hsa042100.47518703
121Renin secretion_Homo sapiens_hsa049240.47503106
122Bladder cancer_Homo sapiens_hsa052190.47414678
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.47298055
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46925720
125Sulfur relay system_Homo sapiens_hsa041220.46880312
126Pancreatic cancer_Homo sapiens_hsa052120.44995824
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44971019
128Fructose and mannose metabolism_Homo sapiens_hsa000510.44845562
129Vitamin digestion and absorption_Homo sapiens_hsa049770.44584881
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44374359
131Measles_Homo sapiens_hsa051620.43602093
132Glucagon signaling pathway_Homo sapiens_hsa049220.42946682
133Herpes simplex infection_Homo sapiens_hsa051680.41872985
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41867903
135Leishmaniasis_Homo sapiens_hsa051400.40041248
136Type II diabetes mellitus_Homo sapiens_hsa049300.39838049
137Toxoplasmosis_Homo sapiens_hsa051450.39739679
138Cardiac muscle contraction_Homo sapiens_hsa042600.38763929
139Osteoclast differentiation_Homo sapiens_hsa043800.38725201
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38389508
141Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37021710
142Thyroid cancer_Homo sapiens_hsa052160.36804789
143Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35755169
144Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34932930
145Lysine degradation_Homo sapiens_hsa003100.34110696
146Estrogen signaling pathway_Homo sapiens_hsa049150.33977981
147Thyroid hormone synthesis_Homo sapiens_hsa049180.33893723
148Hepatitis B_Homo sapiens_hsa051610.32787944
149Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32165017
150Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28946918
151MicroRNAs in cancer_Homo sapiens_hsa052060.28495479
152Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25179681
153Central carbon metabolism in cancer_Homo sapiens_hsa052300.23298220
154Prion diseases_Homo sapiens_hsa050200.22061462
155Chemical carcinogenesis_Homo sapiens_hsa052040.21412185
156Retinol metabolism_Homo sapiens_hsa008300.20587400
157Starch and sucrose metabolism_Homo sapiens_hsa005000.20126735
158ECM-receptor interaction_Homo sapiens_hsa045120.18605988
159Renin-angiotensin system_Homo sapiens_hsa046140.18595448
160Small cell lung cancer_Homo sapiens_hsa052220.18308017
161Sulfur metabolism_Homo sapiens_hsa009200.17956125
162Histidine metabolism_Homo sapiens_hsa003400.17021651
163Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15803790

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