RABL2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the RAB gene family which belongs to the RAS GTPase superfamily. The proteins in the family of RAS-related signaling molecules are small GTP-binding proteins that play important roles in the regulation of exocytotic and endocytotic pathways. This gene maps to the site of an ancestral telomere fusion event and may be a subtelomeric gene. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.34993843
2axoneme assembly (GO:0035082)8.01190653
3regulation of cilium movement (GO:0003352)7.00600900
4left/right pattern formation (GO:0060972)6.12888988
5intraciliary transport (GO:0042073)5.46202308
6cilium organization (GO:0044782)5.32216618
7cilium assembly (GO:0042384)5.18238312
8left/right axis specification (GO:0070986)4.99964931
9protein localization to cilium (GO:0061512)4.90045074
10regulation of microtubule-based movement (GO:0060632)4.79565189
11microtubule bundle formation (GO:0001578)4.73263877
12ventricular system development (GO:0021591)4.64732618
13cilium morphogenesis (GO:0060271)4.32839998
14cellular component assembly involved in morphogenesis (GO:0010927)4.03914088
15nonmotile primary cilium assembly (GO:0035058)3.72655828
16behavioral response to nicotine (GO:0035095)3.61693430
17centriole assembly (GO:0098534)3.58380634
18microtubule-based movement (GO:0007018)3.49454060
19cell projection assembly (GO:0030031)3.44589064
20vitamin transmembrane transport (GO:0035461)3.44151883
21tolerance induction (GO:0002507)3.42495731
22protein polyglutamylation (GO:0018095)3.40562378
23primary alcohol catabolic process (GO:0034310)3.37886743
24negative regulation of T cell differentiation in thymus (GO:0033085)3.28038575
25negative regulation of immunoglobulin mediated immune response (GO:0002890)3.11832938
26negative regulation of B cell mediated immunity (GO:0002713)3.11832938
27response to xenobiotic stimulus (GO:0009410)3.06326498
28sperm motility (GO:0030317)3.05631633
29pyrimidine nucleobase catabolic process (GO:0006208)3.03841307
30nucleoside diphosphate phosphorylation (GO:0006165)3.03770095
31one-carbon compound transport (GO:0019755)2.99277812
32lateral sprouting from an epithelium (GO:0060601)2.99227431
33lung epithelium development (GO:0060428)2.98309141
34smoothened signaling pathway (GO:0007224)2.94808451
35determination of left/right symmetry (GO:0007368)2.91926370
36ethanol metabolic process (GO:0006067)2.90690667
37centriole replication (GO:0007099)2.87479161
38regulation of germinal center formation (GO:0002634)2.83626674
39regulation of collateral sprouting (GO:0048670)2.81022187
40gamma-aminobutyric acid transport (GO:0015812)2.78728234
41exogenous drug catabolic process (GO:0042738)2.78009139
42pyrimidine-containing compound transmembrane transport (GO:0072531)2.73716866
43determination of bilateral symmetry (GO:0009855)2.70550467
44lateral ventricle development (GO:0021670)2.67471088
45neurotransmitter metabolic process (GO:0042133)2.66770104
46brain morphogenesis (GO:0048854)2.63316116
47neurotransmitter catabolic process (GO:0042135)2.62958860
48specification of symmetry (GO:0009799)2.60715658
49diterpenoid biosynthetic process (GO:0016102)2.59026459
50regulation of interleukin-5 production (GO:0032674)2.57969739
51neural tube formation (GO:0001841)2.54959449
52neuronal action potential (GO:0019228)2.54905527
53photoreceptor cell maintenance (GO:0045494)2.54654717
54cornea development in camera-type eye (GO:0061303)2.53226334
55spinal cord motor neuron differentiation (GO:0021522)2.52194715
56retinal cone cell development (GO:0046549)2.52188360
57transmission of nerve impulse (GO:0019226)2.50736268
58cytoplasmic microtubule organization (GO:0031122)2.49699435
59establishment of tissue polarity (GO:0007164)2.49143080
60establishment of planar polarity (GO:0001736)2.49143080
61drug catabolic process (GO:0042737)2.49010058
62behavioral response to ethanol (GO:0048149)2.44970454
63auditory behavior (GO:0031223)2.44919885
64epithelial cell differentiation involved in kidney development (GO:0035850)2.44481197
65sialylation (GO:0097503)2.44452842
66negative regulation of telomere maintenance (GO:0032205)2.40673253
67regulation of interleukin-13 production (GO:0032656)2.38042575
68nucleobase catabolic process (GO:0046113)2.37494407
69phosphatidylcholine biosynthetic process (GO:0006656)2.36944044
70microtubule polymerization or depolymerization (GO:0031109)2.36255024
71dendritic spine morphogenesis (GO:0060997)2.35944047
72appendage development (GO:0048736)2.34988412
73limb development (GO:0060173)2.34988412
74aldehyde catabolic process (GO:0046185)2.33459919
75fucose catabolic process (GO:0019317)2.33293708
76L-fucose metabolic process (GO:0042354)2.33293708
77L-fucose catabolic process (GO:0042355)2.33293708
78sperm capacitation (GO:0048240)2.33183904
79nucleotide transmembrane transport (GO:1901679)2.32119268
80retinal rod cell development (GO:0046548)2.30282529
81microtubule depolymerization (GO:0007019)2.30210874
82positive regulation of oligodendrocyte differentiation (GO:0048714)2.26871044
83cell migration in hindbrain (GO:0021535)2.24405210
84cell differentiation in spinal cord (GO:0021515)2.22640029
85positive regulation of tolerance induction (GO:0002645)2.21255995
86organelle assembly (GO:0070925)2.20821569
87central nervous system myelination (GO:0022010)2.20385449
88axon ensheathment in central nervous system (GO:0032291)2.20385449
89negative regulation of oligodendrocyte differentiation (GO:0048715)2.20210304
90glycosphingolipid biosynthetic process (GO:0006688)2.18119853
91synaptic transmission, glutamatergic (GO:0035249)2.17754832
92ionotropic glutamate receptor signaling pathway (GO:0035235)2.17629638
93preassembly of GPI anchor in ER membrane (GO:0016254)2.17488197
94vocalization behavior (GO:0071625)2.16503610
95regulation of synapse structural plasticity (GO:0051823)2.14924685
96axonemal dynein complex assembly (GO:0070286)13.9701483
97cilium or flagellum-dependent cell motility (GO:0001539)12.4596937
98cilium movement (GO:0003341)11.2318034
99epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)11.1030138
100epithelial cilium movement (GO:0003351)10.3912149

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.56676521
2DROSHA_22980978_ChIP-Seq_HELA_Human3.15099658
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.70586812
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.52363867
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.42655915
6ZNF274_21170338_ChIP-Seq_K562_Hela2.37241767
7VDR_22108803_ChIP-Seq_LS180_Human2.36787565
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18798804
9GBX2_23144817_ChIP-Seq_PC3_Human2.07465174
10REST_21632747_ChIP-Seq_MESCs_Mouse2.05830587
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90202912
12CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85148494
13CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85010993
14* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.84299801
15EZH2_27294783_Chip-Seq_ESCs_Mouse1.79357783
16IGF1R_20145208_ChIP-Seq_DFB_Human1.71903139
17TAF15_26573619_Chip-Seq_HEK293_Human1.71856155
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71736308
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59603823
20AR_21572438_ChIP-Seq_LNCaP_Human1.57066115
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54764967
22NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48794081
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47700253
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.47293011
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44538344
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43687629
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43118282
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41055253
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.37330337
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37059953
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35725282
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.35609603
33RNF2_27304074_Chip-Seq_NSC_Mouse1.35216222
34* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33794781
35TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.31486759
36TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30690904
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.30071600
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29796507
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.26114495
40SMAD4_21799915_ChIP-Seq_A2780_Human1.24348159
41BCAT_22108803_ChIP-Seq_LS180_Human1.23675090
42ER_23166858_ChIP-Seq_MCF-7_Human1.23300252
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22870212
44FUS_26573619_Chip-Seq_HEK293_Human1.22476446
45PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20975604
46EWS_26573619_Chip-Seq_HEK293_Human1.20878515
47STAT3_23295773_ChIP-Seq_U87_Human1.20167683
48CBP_20019798_ChIP-Seq_JUKART_Human1.20009239
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20009239
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.18827969
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17519066
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16729519
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16231985
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14783760
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14783760
56ERA_21632823_ChIP-Seq_H3396_Human1.14195200
57SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12132134
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12093301
59RUNX2_22187159_ChIP-Seq_PCA_Human1.10930562
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10453797
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10369627
62FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10197929
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08927845
64NCOR_22424771_ChIP-Seq_293T_Human1.07755927
65* TCF4_23295773_ChIP-Seq_U87_Human1.06902053
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06696505
67CTCF_27219007_Chip-Seq_Bcells_Human1.05847142
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.05701371
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.05697516
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05146230
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04522381
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.03952385
73MYC_19829295_ChIP-Seq_ESCs_Human1.03851388
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03457858
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03273110
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02649543
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.02629126
78P300_19829295_ChIP-Seq_ESCs_Human1.01962050
79* AR_25329375_ChIP-Seq_VCAP_Human1.00935004
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00794235
81TCF4_22108803_ChIP-Seq_LS180_Human1.00432126
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00299522
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.00299522
84OCT4_20526341_ChIP-Seq_ESCs_Human0.99272812
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98837350
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96041477
87EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95997616
88GATA3_21878914_ChIP-Seq_MCF-7_Human0.95720212
89ETV1_20927104_ChIP-Seq_GIST48_Human0.94954089
90SMAD4_21741376_ChIP-Seq_EPCs_Human0.93210802
91EZH2_18974828_ChIP-Seq_MESCs_Mouse0.92963448
92RNF2_18974828_ChIP-Seq_MESCs_Mouse0.92963448
93SMRT_27268052_Chip-Seq_Bcells_Human0.92188065
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90567038
95SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90141432
96AR_19668381_ChIP-Seq_PC3_Human0.89902465
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89680552
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89611363
99WDR5_24793694_ChIP-Seq_LNCAP_Human0.89317867
100* TP53_22573176_ChIP-Seq_HFKS_Human0.89205870

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.61526251
2MP0001984_abnormal_olfaction3.35830222
3MP0008875_abnormal_xenobiotic_pharmacok3.34013116
4MP0003880_abnormal_central_pattern3.02125117
5MP0004133_heterotaxia2.87032640
6MP0004043_abnormal_pH_regulation2.44473666
7MP0008789_abnormal_olfactory_epithelium2.44050078
8MP0003136_yellow_coat_color2.35276120
9MP0002735_abnormal_chemical_nociception2.21917288
10MP0002132_abnormal_respiratory_system2.21242098
11MP0002822_catalepsy2.18545710
12MP0005394_taste/olfaction_phenotype2.17644599
13MP0005499_abnormal_olfactory_system2.17644599
14MP0000566_synostosis2.08862980
15MP0004859_abnormal_synaptic_plasticity2.05995516
16MP0009046_muscle_twitch2.02376875
17MP0009745_abnormal_behavioral_response2.01123509
18MP0001968_abnormal_touch/_nociception1.93282918
19MP0002277_abnormal_respiratory_mucosa1.85838733
20MP0005551_abnormal_eye_electrophysiolog1.79688323
21MP0006276_abnormal_autonomic_nervous1.79509946
22MP0003878_abnormal_ear_physiology1.78843503
23MP0005377_hearing/vestibular/ear_phenot1.78843503
24MP0005423_abnormal_somatic_nervous1.72307883
25MP0002572_abnormal_emotion/affect_behav1.71963414
26MP0003635_abnormal_synaptic_transmissio1.70684342
27MP0002272_abnormal_nervous_system1.70146992
28MP0001986_abnormal_taste_sensitivity1.69809101
29MP0005646_abnormal_pituitary_gland1.69326473
30MP0004885_abnormal_endolymph1.68440332
31MP0001486_abnormal_startle_reflex1.67338478
32MP0002734_abnormal_mechanical_nocicepti1.66949471
33MP0002638_abnormal_pupillary_reflex1.64998902
34MP0002063_abnormal_learning/memory/cond1.63013367
35MP0002064_seizures1.61420133
36MP0000778_abnormal_nervous_system1.59363265
37MP0001970_abnormal_pain_threshold1.55169549
38MP0004142_abnormal_muscle_tone1.46456135
39MP0002557_abnormal_social/conspecific_i1.43105155
40MP0002876_abnormal_thyroid_physiology1.37631079
41MP0005645_abnormal_hypothalamus_physiol1.35535846
42MP0002102_abnormal_ear_morphology1.32025537
43MP0001502_abnormal_circadian_rhythm1.30852377
44MP0006292_abnormal_olfactory_placode1.30471566
45MP0001529_abnormal_vocalization1.30417016
46MP0002736_abnormal_nociception_after1.30230209
47MP0001485_abnormal_pinna_reflex1.26489208
48MP0001905_abnormal_dopamine_level1.26078994
49MP0002160_abnormal_reproductive_system1.24899569
50MP0002733_abnormal_thermal_nociception1.22982924
51MP0000026_abnormal_inner_ear1.22278823
52MP0002282_abnormal_trachea_morphology1.19453501
53MP0000383_abnormal_hair_follicle1.17621911
54MP0000631_abnormal_neuroendocrine_gland1.16533109
55MP0001501_abnormal_sleep_pattern1.16509088
56MP0002067_abnormal_sensory_capabilities1.16407704
57MP0005253_abnormal_eye_physiology1.15883330
58MP0003122_maternal_imprinting1.15229732
59MP0003787_abnormal_imprinting1.13177839
60MP0008872_abnormal_physiological_respon1.06830820
61MP0001346_abnormal_lacrimal_gland1.06337649
62MP0000955_abnormal_spinal_cord1.06322769
63MP0002882_abnormal_neuron_morphology1.05015016
64MP0004742_abnormal_vestibular_system1.03039606
65MP0001963_abnormal_hearing_physiology1.01520333
66MP0001188_hyperpigmentation0.97147669
67MP0003195_calcinosis0.96821917
68MP0003938_abnormal_ear_development0.96807974
69MP0002752_abnormal_somatic_nervous0.96220998
70MP0002909_abnormal_adrenal_gland0.95989580
71MP0002928_abnormal_bile_duct0.95768327
72MP0008995_early_reproductive_senescence0.92792844
73MP0001765_abnormal_ion_homeostasis0.92680666
74MP0005195_abnormal_posterior_eye0.91558495
75MP0002229_neurodegeneration0.91236433
76MP0003011_delayed_dark_adaptation0.90835988
77MP0003698_abnormal_male_reproductive0.90681300
78MP0004924_abnormal_behavior0.88216823
79MP0005386_behavior/neurological_phenoty0.88216823
80MP0004270_analgesia0.86709091
81MP0005389_reproductive_system_phenotype0.84867022
82MP0005083_abnormal_biliary_tract0.80519947
83MP0002249_abnormal_larynx_morphology0.79569728
84MP0008569_lethality_at_weaning0.79432626
85MP0001440_abnormal_grooming_behavior0.78523383
86MP0001324_abnormal_eye_pigmentation0.78517759
87MP0000372_irregular_coat_pigmentation0.78103672
88MP0002233_abnormal_nose_morphology0.77565750
89MP0000049_abnormal_middle_ear0.77264559
90MP0002152_abnormal_brain_morphology0.76592078
91MP0002066_abnormal_motor_capabilities/c0.75810925
92MP0002184_abnormal_innervation0.74215711
93MP0004147_increased_porphyrin_level0.73678611
94MP0002069_abnormal_eating/drinking_beha0.70455269
95MP0004811_abnormal_neuron_physiology0.70150710
96MP0006072_abnormal_retinal_apoptosis0.70134096
97MP0009379_abnormal_foot_pigmentation0.69576669
98MP0005174_abnormal_tail_pigmentation0.67128270
99MP0005075_abnormal_melanosome_morpholog0.62864604
100MP0008877_abnormal_DNA_methylation0.62523615

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.50421818
2Abnormal respiratory motile cilium morphology (HP:0005938)9.40748020
3Abnormal respiratory epithelium morphology (HP:0012253)9.40748020
4Dynein arm defect of respiratory motile cilia (HP:0012255)9.24189968
5Absent/shortened dynein arms (HP:0200106)9.24189968
6Abnormal ciliary motility (HP:0012262)8.89799903
7Abnormal respiratory motile cilium physiology (HP:0012261)8.77376001
8Rhinitis (HP:0012384)7.70079841
9Bronchiectasis (HP:0002110)5.66707579
10Chronic bronchitis (HP:0004469)5.39744676
11Nasal polyposis (HP:0100582)4.82537571
12Pancreatic fibrosis (HP:0100732)4.64258498
13True hermaphroditism (HP:0010459)4.63099584
14Abnormality of midbrain morphology (HP:0002418)4.34108921
15Molar tooth sign on MRI (HP:0002419)4.34108921
16Pancreatic cysts (HP:0001737)4.23966045
17Nephronophthisis (HP:0000090)4.05324309
18Abnormality of the nasal mucosa (HP:0000433)3.79678146
19Occipital encephalocele (HP:0002085)3.70210503
20Cystic liver disease (HP:0006706)3.69323600
21Chronic sinusitis (HP:0011109)3.54687396
22Recurrent sinusitis (HP:0011108)3.44963731
23Chronic hepatic failure (HP:0100626)3.33909996
24Abnormality of the renal medulla (HP:0100957)3.27667067
25Infertility (HP:0000789)3.25245864
26Medial flaring of the eyebrow (HP:0010747)3.24286147
27Bronchitis (HP:0012387)3.07629508
28Gait imbalance (HP:0002141)3.01432515
29Postaxial foot polydactyly (HP:0001830)2.89149723
30Congenital primary aphakia (HP:0007707)2.86479706
31Chronic otitis media (HP:0000389)2.80130690
32Recurrent otitis media (HP:0000403)2.73692892
33Anencephaly (HP:0002323)2.70629401
34Congenital hepatic fibrosis (HP:0002612)2.63687734
35Nephrogenic diabetes insipidus (HP:0009806)2.58159605
36Sclerocornea (HP:0000647)2.56632736
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.50508225
38Tubular atrophy (HP:0000092)2.32418875
39Male pseudohermaphroditism (HP:0000037)2.32027333
40Tubulointerstitial nephritis (HP:0001970)2.31475521
41Male infertility (HP:0003251)2.30999779
42Abnormal drinking behavior (HP:0030082)2.25274213
43Polydipsia (HP:0001959)2.25274213
44Postaxial hand polydactyly (HP:0001162)2.21521388
45Congenital stationary night blindness (HP:0007642)2.12715429
46Genital tract atresia (HP:0001827)2.11137829
47Vaginal atresia (HP:0000148)2.09681269
48Furrowed tongue (HP:0000221)2.08465393
49Aplasia/Hypoplasia of the spleen (HP:0010451)2.06236625
50Asplenia (HP:0001746)2.01812403
51Atelectasis (HP:0100750)1.99756794
52Decreased circulating renin level (HP:0003351)1.98843094
53Oculomotor apraxia (HP:0000657)1.98136383
54Poor coordination (HP:0002370)1.96848019
55Abnormality of the renal cortex (HP:0011035)1.95441086
56Decreased central vision (HP:0007663)1.93978695
57Absent speech (HP:0001344)1.84744438
58Bile duct proliferation (HP:0001408)1.83736009
59Abnormal biliary tract physiology (HP:0012439)1.83736009
60Progressive cerebellar ataxia (HP:0002073)1.83009898
61Hyperactive renin-angiotensin system (HP:0000841)1.80675107
62Preaxial hand polydactyly (HP:0001177)1.80302442
63Nephropathy (HP:0000112)1.76546734
64Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72757989
65Tubulointerstitial abnormality (HP:0001969)1.72575453
66Abnormal rod and cone electroretinograms (HP:0008323)1.67469561
67Polyuria (HP:0000103)1.61281925
68Narrow forehead (HP:0000341)1.61144175
69Stage 5 chronic kidney disease (HP:0003774)1.57487501
70Retinitis pigmentosa (HP:0000510)1.56569451
71Abnormality of macular pigmentation (HP:0008002)1.54210966
72Specific learning disability (HP:0001328)1.52199011
73Hyperventilation (HP:0002883)1.51988899
74Renal salt wasting (HP:0000127)1.49880568
75Polyphagia (HP:0002591)1.49601686
76Abolished electroretinogram (ERG) (HP:0000550)1.48648883
77Recurrent bronchitis (HP:0002837)1.48050330
78Broad-based gait (HP:0002136)1.47847684
79Aganglionic megacolon (HP:0002251)1.44417481
80Aplasia/Hypoplasia of the lens (HP:0008063)1.42279157
81Tubulointerstitial fibrosis (HP:0005576)1.41553574
82Prominent nasal bridge (HP:0000426)1.41242848
83Bell-shaped thorax (HP:0001591)1.40785966
84Myokymia (HP:0002411)1.39731486
85Optic nerve coloboma (HP:0000588)1.38823334
86Broad foot (HP:0001769)1.38556550
87Focal motor seizures (HP:0011153)1.37926831
88Median cleft lip (HP:0000161)1.37530634
89Abnormality of renin-angiotensin system (HP:0000847)1.37460101
90Multicystic kidney dysplasia (HP:0000003)1.35981907
91Hyperaldosteronism (HP:0000859)1.33970819
92Type II lissencephaly (HP:0007260)1.33442387
93Focal seizures (HP:0007359)1.33117397
94Epileptic encephalopathy (HP:0200134)1.31952581
95Genetic anticipation (HP:0003743)1.31297099
96Highly arched eyebrow (HP:0002553)1.29776850
97Attenuation of retinal blood vessels (HP:0007843)1.28197606
98Sleep apnea (HP:0010535)1.25874216
99Bony spicule pigmentary retinopathy (HP:0007737)1.25494859
100Abnormal urine output (HP:0012590)1.25289131

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK157.29322745
2TLK12.46290319
3FRK2.37268977
4WNK42.33556686
5MAP3K42.09518779
6MAP4K22.07906215
7BCR2.06905252
8NME12.06154112
9SIK22.00427454
10ADRBK21.95392572
11MARK11.90640438
12MAPK131.84396169
13BMPR1B1.77540440
14TXK1.74222006
15CASK1.73781019
16NTRK21.59825651
17PINK11.58977292
18EPHA31.57268345
19EPHA41.57017143
20CAMKK11.53554512
21GRK11.51771651
22DYRK21.50680397
23MAP2K71.44494968
24BCKDK1.43014566
25TAOK31.42707937
26PNCK1.39450835
27INSRR1.37879100
28MAP2K61.34091043
29WNK31.29559970
30NTRK31.29163417
31DAPK21.27240991
32PTK2B1.24767779
33MST41.24544856
34MAPKAPK31.12569392
35TNK21.10705618
36DYRK1A1.09079984
37DYRK1B1.01846464
38MAP3K71.00785841
39OXSR10.97843187
40CDK190.97401678
41CAMKK20.96685024
42STK390.94383735
43GRK60.91250599
44ADRBK10.89961195
45PRKCG0.86471600
46MAP2K40.85748192
47PRKD30.84827887
48PRKCQ0.83019340
49CSNK1G20.80152989
50ERBB20.78582247
51MARK20.73898532
52RIPK40.73140091
53MAPKAPK50.72485913
54EPHA20.72302475
55ZAK0.71694299
56CSNK1A1L0.68945554
57PAK30.66221419
58KIT0.66022050
59TNIK0.64603351
60STK240.62964084
61MINK10.62767807
62FGFR20.62749582
63CAMK10.62732785
64CSNK1G30.62065790
65ERBB30.60304158
66SGK4940.59947811
67SGK2230.59947811
68PASK0.59298793
69CDK50.58989057
70STK110.58512550
71EPHB10.57518078
72PRKCZ0.57167868
73CAMK2A0.57026791
74PHKG10.54653428
75PHKG20.54653428
76PKN10.52835008
77EPHB20.52346476
78PRKCE0.51736890
79ITK0.49386266
80PRKACA0.46939882
81CSK0.46586319
82SYK0.46475534
83TGFBR10.46070172
84SGK10.43872560
85UHMK10.43772552
86IKBKE0.40417149
87HIPK20.39695275
88SGK20.39322989
89CSNK1G10.38618787
90MUSK0.37747618
91WNK10.36659729
92GRK70.34731834
93CSNK1A10.34026533
94TEC0.33674382
95PRKCA0.33594004
96LYN0.33246047
97PRKCI0.32599232
98ACVR1B0.32445173
99BTK0.32152450
100STK160.32044275

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.09909099
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.04822365
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.76903017
4Linoleic acid metabolism_Homo sapiens_hsa005912.59251273
5Chemical carcinogenesis_Homo sapiens_hsa052042.49425198
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.33487127
7Phototransduction_Homo sapiens_hsa047442.33073201
8Histidine metabolism_Homo sapiens_hsa003402.23585671
9Huntingtons disease_Homo sapiens_hsa050162.16959100
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16086241
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.12837814
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.86874393
13Caffeine metabolism_Homo sapiens_hsa002321.84731208
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82637308
15Taste transduction_Homo sapiens_hsa047421.82261128
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.81876116
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78898370
18Phenylalanine metabolism_Homo sapiens_hsa003601.69463387
19beta-Alanine metabolism_Homo sapiens_hsa004101.66485118
20Morphine addiction_Homo sapiens_hsa050321.66033773
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.60628451
22Cocaine addiction_Homo sapiens_hsa050301.60169179
23GABAergic synapse_Homo sapiens_hsa047271.53926831
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.48976653
25Tyrosine metabolism_Homo sapiens_hsa003501.43703140
26Glutamatergic synapse_Homo sapiens_hsa047241.41410529
27Circadian entrainment_Homo sapiens_hsa047131.39326931
28Oxidative phosphorylation_Homo sapiens_hsa001901.36550099
29Nitrogen metabolism_Homo sapiens_hsa009101.34721894
30Butanoate metabolism_Homo sapiens_hsa006501.31827103
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31084461
32Retinol metabolism_Homo sapiens_hsa008301.28873744
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27566870
34Peroxisome_Homo sapiens_hsa041461.27232544
35Serotonergic synapse_Homo sapiens_hsa047261.24779154
36ABC transporters_Homo sapiens_hsa020101.23643166
37Olfactory transduction_Homo sapiens_hsa047401.22125150
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.18921108
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17785808
40Ether lipid metabolism_Homo sapiens_hsa005651.17547019
41Salivary secretion_Homo sapiens_hsa049701.16020545
42Regulation of autophagy_Homo sapiens_hsa041401.14979129
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08985688
44Arachidonic acid metabolism_Homo sapiens_hsa005901.07443054
45Amphetamine addiction_Homo sapiens_hsa050311.05632665
46Dopaminergic synapse_Homo sapiens_hsa047281.03632662
47Insulin secretion_Homo sapiens_hsa049111.03533341
48Parkinsons disease_Homo sapiens_hsa050121.02082278
49Cardiac muscle contraction_Homo sapiens_hsa042600.95493522
50Collecting duct acid secretion_Homo sapiens_hsa049660.93246019
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92555901
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.92199178
53Calcium signaling pathway_Homo sapiens_hsa040200.91939459
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91253207
55Circadian rhythm_Homo sapiens_hsa047100.90399369
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85455072
57Synaptic vesicle cycle_Homo sapiens_hsa047210.85442905
58Primary immunodeficiency_Homo sapiens_hsa053400.80338340
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.79965071
60Hedgehog signaling pathway_Homo sapiens_hsa043400.76650359
61Fanconi anemia pathway_Homo sapiens_hsa034600.74133837
62Graft-versus-host disease_Homo sapiens_hsa053320.73536293
63cAMP signaling pathway_Homo sapiens_hsa040240.73080012
64Cholinergic synapse_Homo sapiens_hsa047250.72654488
65Tryptophan metabolism_Homo sapiens_hsa003800.71740915
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.71119171
67Axon guidance_Homo sapiens_hsa043600.70959896
68Asthma_Homo sapiens_hsa053100.70185422
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65016923
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63827504
71Alzheimers disease_Homo sapiens_hsa050100.63759826
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62053025
73Autoimmune thyroid disease_Homo sapiens_hsa053200.60636801
74Type I diabetes mellitus_Homo sapiens_hsa049400.60083767
75Sulfur relay system_Homo sapiens_hsa041220.58596880
76Oxytocin signaling pathway_Homo sapiens_hsa049210.58197171
77Allograft rejection_Homo sapiens_hsa053300.57474137
78Ovarian steroidogenesis_Homo sapiens_hsa049130.56589325
79Glycerolipid metabolism_Homo sapiens_hsa005610.55454511
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55308505
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54621672
82Basal cell carcinoma_Homo sapiens_hsa052170.51478736
83Gastric acid secretion_Homo sapiens_hsa049710.50408381
84Protein export_Homo sapiens_hsa030600.48683276
85Glutathione metabolism_Homo sapiens_hsa004800.45642873
86Long-term depression_Homo sapiens_hsa047300.45100118
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.43250030
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43197573
89Notch signaling pathway_Homo sapiens_hsa043300.43031391
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39696155
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.39246969
92Sphingolipid metabolism_Homo sapiens_hsa006000.39096746
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37980314
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36923396
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36824136
96Metabolic pathways_Homo sapiens_hsa011000.36003078
97Choline metabolism in cancer_Homo sapiens_hsa052310.34203239
98Steroid biosynthesis_Homo sapiens_hsa001000.32610905
99Fatty acid degradation_Homo sapiens_hsa000710.30975002
100Renin secretion_Homo sapiens_hsa049240.27285566

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