RABL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase biosynthetic process (GO:0046112)4.52243141
2purine nucleobase biosynthetic process (GO:0009113)4.38341232
3cullin deneddylation (GO:0010388)4.16392870
4DNA strand elongation involved in DNA replication (GO:0006271)4.11956406
5DNA double-strand break processing (GO:0000729)4.09163604
6DNA strand elongation (GO:0022616)4.00315358
7protein deneddylation (GO:0000338)3.97747406
8response to nitrosative stress (GO:0051409)3.93496489
9water-soluble vitamin biosynthetic process (GO:0042364)3.89016131
10protein neddylation (GO:0045116)3.80556406
11formation of translation preinitiation complex (GO:0001731)3.75979579
12regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.75402377
13regulation of mitotic spindle checkpoint (GO:1903504)3.75402377
14telomere maintenance via semi-conservative replication (GO:0032201)3.74652081
15proteasome assembly (GO:0043248)3.73990557
16DNA replication checkpoint (GO:0000076)3.73704402
17ribonucleoprotein complex disassembly (GO:0032988)3.71960813
18negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59961074
19mitotic metaphase plate congression (GO:0007080)3.59906775
20platelet dense granule organization (GO:0060155)3.58747924
21nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.55768510
22DNA replication initiation (GO:0006270)3.55485777
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.54200319
24protein polyglutamylation (GO:0018095)3.50878098
25L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.48427531
26CENP-A containing nucleosome assembly (GO:0034080)3.46139405
27exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.45753054
28chaperone-mediated protein transport (GO:0072321)3.39752759
29regulation of glucokinase activity (GO:0033131)3.37552918
30regulation of hexokinase activity (GO:1903299)3.37552918
31negative regulation of leukocyte chemotaxis (GO:0002689)3.37304233
32chromatin remodeling at centromere (GO:0031055)3.36916200
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.36544348
34regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.35836079
35DNA deamination (GO:0045006)3.34835083
36protein complex biogenesis (GO:0070271)3.33838977
37telomere maintenance via recombination (GO:0000722)3.32128526
38organelle disassembly (GO:1903008)3.31610992
39respiratory chain complex IV assembly (GO:0008535)3.31014654
40anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.30663003
41deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.27522934
42RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.27200523
43tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.27200523
44regulation of cellular amino acid metabolic process (GO:0006521)3.24741196
45xenobiotic catabolic process (GO:0042178)3.24508059
46ubiquinone biosynthetic process (GO:0006744)3.24187962
47RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.23928597
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.21118594
49negative regulation of ligase activity (GO:0051352)3.21118594
50branched-chain amino acid catabolic process (GO:0009083)3.17191715
51kinetochore organization (GO:0051383)3.16989942
527-methylguanosine mRNA capping (GO:0006370)3.15044592
53metaphase plate congression (GO:0051310)3.14960300
54mitochondrial respiratory chain complex I assembly (GO:0032981)3.14746730
55NADH dehydrogenase complex assembly (GO:0010257)3.14746730
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.14746730
57amino acid salvage (GO:0043102)3.14642551
58L-methionine salvage (GO:0071267)3.14642551
59L-methionine biosynthetic process (GO:0071265)3.14642551
60folic acid-containing compound biosynthetic process (GO:0009396)3.14424464
61response to pheromone (GO:0019236)3.13065436
62folic acid metabolic process (GO:0046655)3.12996645
63deoxyribonucleotide biosynthetic process (GO:0009263)3.12473800
64mannosylation (GO:0097502)3.12082241
65mitotic recombination (GO:0006312)3.12054357
66DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.11282508
67adenosine metabolic process (GO:0046085)3.11089773
68electron transport chain (GO:0022900)3.09203672
69ubiquinone metabolic process (GO:0006743)3.08118243
70pseudouridine synthesis (GO:0001522)3.08104344
71DNA unwinding involved in DNA replication (GO:0006268)3.07193395
72signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06218878
73intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06218878
74respiratory electron transport chain (GO:0022904)3.06163213
75mitochondrial respiratory chain complex assembly (GO:0033108)3.05551501
76RNA capping (GO:0036260)3.05141651
777-methylguanosine RNA capping (GO:0009452)3.05141651
78signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.04530538
79signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.04530538
80signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.04530538
81ribosome assembly (GO:0042255)3.03155357
82kinetochore assembly (GO:0051382)3.01058399
83protein localization to kinetochore (GO:0034501)3.00219321
84nucleotide-excision repair, DNA gap filling (GO:0006297)2.99559617
85serine family amino acid biosynthetic process (GO:0009070)2.97909788
86pteridine-containing compound biosynthetic process (GO:0042559)2.96256312
87signal transduction involved in DNA damage checkpoint (GO:0072422)2.95487526
88signal transduction involved in DNA integrity checkpoint (GO:0072401)2.95487526
89signal transduction involved in cell cycle checkpoint (GO:0072395)2.94678100
90DNA demethylation (GO:0080111)2.93385173
91positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.92990830
922-deoxyribonucleotide biosynthetic process (GO:0009265)2.92309936
93deoxyribose phosphate biosynthetic process (GO:0046385)2.92309936
94establishment of chromosome localization (GO:0051303)2.91754339
95sequestering of actin monomers (GO:0042989)2.91240029
96establishment of integrated proviral latency (GO:0075713)2.90844291
97DNA catabolic process, exonucleolytic (GO:0000738)2.90219886
98pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.89415558
99G1/S transition of mitotic cell cycle (GO:0000082)2.88444866
100cell cycle G1/S phase transition (GO:0044843)2.88444866
101transcription-coupled nucleotide-excision repair (GO:0006283)2.87930870
102telomere maintenance via telomere lengthening (GO:0010833)2.87266454
103glycine metabolic process (GO:0006544)2.87025016
104regulation of cilium movement (GO:0003352)2.86205210
105cytochrome complex assembly (GO:0017004)2.86106856
106neural tube formation (GO:0001841)2.85197436
107pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.85009289
108attachment of spindle microtubules to kinetochore (GO:0008608)2.84651317
109signal peptide processing (GO:0006465)2.84431726
110preassembly of GPI anchor in ER membrane (GO:0016254)2.83477354
111lysine metabolic process (GO:0006553)2.82878801
112lysine catabolic process (GO:0006554)2.82878801
113maturation of 5.8S rRNA (GO:0000460)2.82846586
114positive regulation of ligase activity (GO:0051351)2.82214079
115mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.82073569
116antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.81927436
117L-serine metabolic process (GO:0006563)2.81446471
118viral mRNA export from host cell nucleus (GO:0046784)2.81399827
119fatty acid elongation (GO:0030497)2.80236773
120somatic diversification of immune receptors via somatic mutation (GO:0002566)2.80171032
121somatic hypermutation of immunoglobulin genes (GO:0016446)2.80171032
122spindle assembly checkpoint (GO:0071173)2.79940368
123rRNA modification (GO:0000154)2.79690712
124negative regulation of sister chromatid segregation (GO:0033046)2.79103562
125negative regulation of mitotic sister chromatid separation (GO:2000816)2.79103562
126negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79103562
127negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.79103562
128IMP biosynthetic process (GO:0006188)2.78958587
129DNA replication-independent nucleosome assembly (GO:0006336)2.78689015
130DNA replication-independent nucleosome organization (GO:0034724)2.78689015
131mitotic spindle assembly checkpoint (GO:0007094)2.78687972
132spliceosomal snRNP assembly (GO:0000387)2.78437858
133cell fate commitment involved in formation of primary germ layer (GO:0060795)2.78104280
134tetrahydrofolate metabolic process (GO:0046653)2.77605776
135negative regulation of chromosome segregation (GO:0051985)2.75803716
136spindle checkpoint (GO:0031577)2.75750316
137erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.75377485
138L-phenylalanine metabolic process (GO:0006558)2.75377485
139anterograde synaptic vesicle transport (GO:0048490)2.74991786
140histone exchange (GO:0043486)2.74880772
141pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.74453117
142negative regulation of mast cell activation (GO:0033004)2.73297245
143DNA damage response, detection of DNA damage (GO:0042769)2.73208100
144oxidative phosphorylation (GO:0006119)2.73106069
145termination of RNA polymerase III transcription (GO:0006386)2.73103041
146transcription elongation from RNA polymerase III promoter (GO:0006385)2.73103041
147tRNA processing (GO:0008033)2.72927673
148erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.72872905
149L-phenylalanine catabolic process (GO:0006559)2.72872905
150aspartate family amino acid catabolic process (GO:0009068)2.71896970
151ribosome biogenesis (GO:0042254)2.71510526
152mitotic nuclear envelope disassembly (GO:0007077)2.71501868
153ATP synthesis coupled proton transport (GO:0015986)2.71280757
154energy coupled proton transport, down electrochemical gradient (GO:0015985)2.71280757
155indolalkylamine metabolic process (GO:0006586)2.70684152
156protein-cofactor linkage (GO:0018065)2.70021042
157aldehyde catabolic process (GO:0046185)2.69965683
158negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.69271206
159fucose catabolic process (GO:0019317)2.69222055
160L-fucose metabolic process (GO:0042354)2.69222055
161L-fucose catabolic process (GO:0042355)2.69222055
162dopamine transport (GO:0015872)2.69024272
163positive regulation of mRNA 3-end processing (GO:0031442)2.64660605
164GPI anchor metabolic process (GO:0006505)2.64052639
165protein localization to cilium (GO:0061512)2.63579698
166peptidyl-histidine modification (GO:0018202)2.61977327
167negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.60933604
168glutathione derivative biosynthetic process (GO:1901687)2.58234041
169glutathione derivative metabolic process (GO:1901685)2.58234041
170proton transport (GO:0015992)2.55663650
171estrogen biosynthetic process (GO:0006703)2.54835937

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.29313210
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.33104797
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.98053608
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.72381466
5* EST1_17652178_ChIP-ChIP_JURKAT_Human3.54765155
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.40837038
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.35807536
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.13173841
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.04945158
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.99483074
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.88631019
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.85582515
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85249841
14* ELF1_17652178_ChIP-ChIP_JURKAT_Human2.81239509
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80213832
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.72780232
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.71563987
18ZNF274_21170338_ChIP-Seq_K562_Hela2.66689930
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60731271
20IGF1R_20145208_ChIP-Seq_DFB_Human2.59669788
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.54470083
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.51297724
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.38066546
24DCP1A_22483619_ChIP-Seq_HELA_Human2.37271651
25GBX2_23144817_ChIP-Seq_PC3_Human2.32877461
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.32215862
27* VDR_23849224_ChIP-Seq_CD4+_Human2.31642958
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30760218
29VDR_22108803_ChIP-Seq_LS180_Human2.24859792
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24026007
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.23322151
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.22130700
33* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16298064
34XRN2_22483619_ChIP-Seq_HELA_Human2.14384174
35FOXP3_21729870_ChIP-Seq_TREG_Human2.13410081
36FOXM1_23109430_ChIP-Seq_U2OS_Human2.12457166
37FUS_26573619_Chip-Seq_HEK293_Human2.11236700
38SRF_21415370_ChIP-Seq_HL-1_Mouse2.09205352
39EWS_26573619_Chip-Seq_HEK293_Human2.07532602
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06576714
41AR_21909140_ChIP-Seq_LNCAP_Human2.06023705
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.03912562
43GABP_19822575_ChIP-Seq_HepG2_Human2.03621247
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.98975506
45* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98923483
46ELK1_19687146_ChIP-ChIP_HELA_Human1.96599679
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.94374797
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88186510
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85942202
50* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85698676
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.84565834
52* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82637312
53ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.79375997
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77783881
55P300_19829295_ChIP-Seq_ESCs_Human1.77280938
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74749691
57TAF15_26573619_Chip-Seq_HEK293_Human1.74251857
58TTF2_22483619_ChIP-Seq_HELA_Human1.69499631
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65626125
60ER_23166858_ChIP-Seq_MCF-7_Human1.63568378
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62989245
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.62841763
63* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62810156
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62569070
65* YY1_21170310_ChIP-Seq_MESCs_Mouse1.60821661
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59187062
67IRF1_19129219_ChIP-ChIP_H3396_Human1.58181081
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.56597200
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54102685
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53565093
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53467320
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52189711
73* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47923766
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47481470
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47460644
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46988385
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39808562
78NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39352254
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.39199140
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38991870
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38400205
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.37245664
83KDM5A_27292631_Chip-Seq_BREAST_Human1.35775117
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34401540
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.33874148
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33361225
87* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32386360
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32366836
89AR_25329375_ChIP-Seq_VCAP_Human1.31611502
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30367718
91EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29081548
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28988194
93SMAD4_21799915_ChIP-Seq_A2780_Human1.28198537
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27362176
95TP53_22573176_ChIP-Seq_HFKS_Human1.26931558
96* SOX2_19829295_ChIP-Seq_ESCs_Human1.25035871
97* NANOG_19829295_ChIP-Seq_ESCs_Human1.25035871
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23615529
99CBP_20019798_ChIP-Seq_JUKART_Human1.22825510
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22825510
101* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22768300
102GATA1_22025678_ChIP-Seq_K562_Human1.22163991
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21461244
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20816528
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19412568
106FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18573459
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18213457
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17384437
109HTT_18923047_ChIP-ChIP_STHdh_Human1.16856407
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15796284
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.15703482
112POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15405512
113AR_20517297_ChIP-Seq_VCAP_Human1.15211384
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14037882
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13648607
116OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13610631
117FOXA1_25329375_ChIP-Seq_VCAP_Human1.12570464
118FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12570464
119* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12377288
120TCF4_22108803_ChIP-Seq_LS180_Human1.12205562
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11891475
122TFEB_21752829_ChIP-Seq_HELA_Human1.10624454
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10591254
124P53_22387025_ChIP-Seq_ESCs_Mouse1.09608569
125MYC_18940864_ChIP-ChIP_HL60_Human1.08481991
126FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08445849
127IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07568719
128SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06204113
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05501983
130SMAD3_21741376_ChIP-Seq_EPCs_Human1.05359796
131CDX2_22108803_ChIP-Seq_LS180_Human1.05225096
132* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05208035
133STAT3_18555785_Chip-Seq_ESCs_Mouse1.05154162
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04879749
135DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03883153
136NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03138834
137SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02800481
138FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02583740
139SALL4_22934838_ChIP-ChIP_CD34+_Human1.02218730
140CIITA_25753668_ChIP-Seq_RAJI_Human1.01264244
141P300_18555785_Chip-Seq_ESCs_Mouse1.01181294
142E2F1_18555785_Chip-Seq_ESCs_Mouse1.00987308
143OCT4_18555785_Chip-Seq_ESCs_Mouse1.00286937
144SOX17_20123909_ChIP-Seq_XEN_Mouse1.00224088
145CMYC_18555785_Chip-Seq_ESCs_Mouse0.99946347
146BCAT_22108803_ChIP-Seq_LS180_Human0.99271986
147ELK1_22589737_ChIP-Seq_MCF10A_Human0.98100028
148KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97820195
149CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97798893
150NOTCH1_21737748_ChIP-Seq_TLL_Human0.97264819
151PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93187712
152SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92168005
153RXR_22158963_ChIP-Seq_LIVER_Mouse0.90666586
154POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90032224
155TP63_19390658_ChIP-ChIP_HaCaT_Human0.88640617
156PPARA_22158963_ChIP-Seq_LIVER_Mouse0.84749427
157KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80627084
158ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.79966694
159TBX5_21415370_ChIP-Seq_HL-1_Mouse0.79625100
160CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.76812272
161GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76016668
162CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.75744706
163CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.74909048
164* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.72001359
165GATA4_21415370_ChIP-Seq_HL-1_Mouse0.71330742
166NANOG_21062744_ChIP-ChIP_HESCs_Human0.71118641
167SALL1_21062744_ChIP-ChIP_HESCs_Human0.70380687
168SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.68521800
169SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.67366034
170DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.67275622

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.07666937
2MP0003693_abnormal_embryo_hatching4.18777432
3MP0010094_abnormal_chromosome_stability3.86081145
4MP0002102_abnormal_ear_morphology3.58501359
5MP0008057_abnormal_DNA_replication3.42689741
6MP0004957_abnormal_blastocyst_morpholog3.41677619
7MP0005360_urolithiasis3.31287934
8MP0008058_abnormal_DNA_repair3.25359396
9MP0003111_abnormal_nucleus_morphology3.08216575
10MP0003077_abnormal_cell_cycle2.95445835
11MP0002139_abnormal_hepatobiliary_system2.84241063
12MP0002736_abnormal_nociception_after2.61691130
13MP0005084_abnormal_gallbladder_morpholo2.59395577
14MP0005365_abnormal_bile_salt2.53319935
15MP0008932_abnormal_embryonic_tissue2.42284450
16MP0009697_abnormal_copulation2.38836728
17MP0006072_abnormal_retinal_apoptosis2.34737203
18MP0005085_abnormal_gallbladder_physiolo2.24129660
19MP0008872_abnormal_physiological_respon2.23962571
20MP0003123_paternal_imprinting2.21585849
21MP0005551_abnormal_eye_electrophysiolog2.21278434
22MP0003186_abnormal_redox_activity2.08353288
23MP0008007_abnormal_cellular_replicative2.07607851
24MP0002837_dystrophic_cardiac_calcinosis2.03106697
25MP0005253_abnormal_eye_physiology2.01076493
26MP0003718_maternal_effect1.92182363
27MP0008877_abnormal_DNA_methylation1.91400445
28MP0000427_abnormal_hair_cycle1.91283913
29MP0001727_abnormal_embryo_implantation1.91270062
30MP0001730_embryonic_growth_arrest1.89971060
31MP0002234_abnormal_pharynx_morphology1.88075918
32MP0000647_abnormal_sebaceous_gland1.86146542
33MP0001984_abnormal_olfaction1.85689708
34MP0000372_irregular_coat_pigmentation1.82587147
35MP0001968_abnormal_touch/_nociception1.78640036
36MP0001764_abnormal_homeostasis1.78387154
37MP0003786_premature_aging1.76637679
38MP0002163_abnormal_gland_morphology1.75709294
39MP0003890_abnormal_embryonic-extraembry1.75473380
40MP0000569_abnormal_digit_pigmentation1.73703198
41MP0002876_abnormal_thyroid_physiology1.72540735
42MP0010678_abnormal_skin_adnexa1.68522206
43MP0000383_abnormal_hair_follicle1.67942219
44MP0010030_abnormal_orbit_morphology1.66151689
45MP0003121_genomic_imprinting1.60938574
46MP0006036_abnormal_mitochondrial_physio1.58090579
47MP0008875_abnormal_xenobiotic_pharmacok1.54289474
48MP0004885_abnormal_endolymph1.53812061
49MP0004043_abnormal_pH_regulation1.53489806
50MP0004742_abnormal_vestibular_system1.46852640
51MP0004215_abnormal_myocardial_fiber1.45775225
52MP0009840_abnormal_foam_cell1.43311891
53MP0008789_abnormal_olfactory_epithelium1.43232537
54MP0001697_abnormal_embryo_size1.42880961
55MP0005266_abnormal_metabolism1.42519606
56MP0005645_abnormal_hypothalamus_physiol1.41881071
57MP0000350_abnormal_cell_proliferation1.40010161
58MP0003656_abnormal_erythrocyte_physiolo1.39358414
59MP0001529_abnormal_vocalization1.36560208
60MP0009046_muscle_twitch1.36225907
61MP0002638_abnormal_pupillary_reflex1.33911378
62MP0010386_abnormal_urinary_bladder1.33320010
63MP0002272_abnormal_nervous_system1.29847564
64MP0003122_maternal_imprinting1.28321372
65MP0009053_abnormal_anal_canal1.28282450
66MP0002396_abnormal_hematopoietic_system1.27938940
67MP0005380_embryogenesis_phenotype1.27085482
68MP0001672_abnormal_embryogenesis/_devel1.27085482
69MP0001501_abnormal_sleep_pattern1.26726301
70MP0003984_embryonic_growth_retardation1.23650476
71MP0002088_abnormal_embryonic_growth/wei1.22465422
72MP0009672_abnormal_birth_weight1.21540742
73MP0001293_anophthalmia1.19828133
74MP0005379_endocrine/exocrine_gland_phen1.18827851
75MP0002938_white_spotting1.18286527
76MP0002090_abnormal_vision1.15487744
77MP0005167_abnormal_blood-brain_barrier1.14509440
78MP0002277_abnormal_respiratory_mucosa1.13208464
79MP0002080_prenatal_lethality1.12574167
80MP0001905_abnormal_dopamine_level1.11842149
81MP0005075_abnormal_melanosome_morpholog1.11111081
82MP0005332_abnormal_amino_acid1.10020753
83MP0000230_abnormal_systemic_arterial1.09196141
84MP0003252_abnormal_bile_duct1.07235163
85MP0001188_hyperpigmentation1.05460888
86MP0006276_abnormal_autonomic_nervous1.04238942
87MP0003941_abnormal_skin_development1.03553996
88MP0003011_delayed_dark_adaptation1.03221634
89MP0004197_abnormal_fetal_growth/weight/1.02345101
90MP0006035_abnormal_mitochondrial_morpho1.02258229
91MP0003195_calcinosis1.02186772
92MP0005083_abnormal_biliary_tract1.01567907
93MP0003950_abnormal_plasma_membrane1.00324858
94MP0001986_abnormal_taste_sensitivity0.98726254
95MP0003646_muscle_fatigue0.98373812
96MP0004147_increased_porphyrin_level0.98289753
97MP0002085_abnormal_embryonic_tissue0.98043028
98MP0003880_abnormal_central_pattern0.95710679
99MP0002210_abnormal_sex_determination0.94742845
100MP0001485_abnormal_pinna_reflex0.94311616
101MP0000313_abnormal_cell_death0.94278667
102MP0005319_abnormal_enzyme/_coenzyme0.93859273
103MP0004133_heterotaxia0.93189967
104MP0003567_abnormal_fetal_cardiomyocyte0.92803705
105MP0005220_abnormal_exocrine_pancreas0.92480179
106MP0005376_homeostasis/metabolism_phenot0.90434799
107MP0005636_abnormal_mineral_homeostasis0.90424888
108MP0003724_increased_susceptibility_to0.90078086
109MP0005394_taste/olfaction_phenotype0.89090649
110MP0005499_abnormal_olfactory_system0.89090649
111MP0003137_abnormal_impulse_conducting0.88936088
112MP0004142_abnormal_muscle_tone0.88874376
113MP0002086_abnormal_extraembryonic_tissu0.87451743
114MP0000598_abnormal_liver_morphology0.86761229
115MP0005174_abnormal_tail_pigmentation0.86088677
116MP0005408_hypopigmentation0.85929175
117MP0002019_abnormal_tumor_incidence0.85800066
118MP0003221_abnormal_cardiomyocyte_apopto0.85333616
119MP0002282_abnormal_trachea_morphology0.84974271
120MP0002160_abnormal_reproductive_system0.83810482
121MP0010307_abnormal_tumor_latency0.83461123
122MP0000609_abnormal_liver_physiology0.83377361
123MP0009745_abnormal_behavioral_response0.83207894
124MP0001915_intracranial_hemorrhage0.83085788
125MP0002084_abnormal_developmental_patter0.81563512
126MP0001286_abnormal_eye_development0.81322527
127MP0001177_atelectasis0.80816625
128MP0005391_vision/eye_phenotype0.79780295
129MP0003119_abnormal_digestive_system0.79579552
130MP0006054_spinal_hemorrhage0.79439470
131MP0002095_abnormal_skin_pigmentation0.78983437
132MP0008995_early_reproductive_senescence0.78532345
133MP0002111_abnormal_tail_morphology0.77935065
134MP0000631_abnormal_neuroendocrine_gland0.77756374
135MP0001145_abnormal_male_reproductive0.77271988
136MP0000613_abnormal_salivary_gland0.76621724
137MP0006292_abnormal_olfactory_placode0.75615988
138MP0003943_abnormal_hepatobiliary_system0.75375677
139MP0001666_abnormal_nutrient_absorption0.75110035
140MP0004019_abnormal_vitamin_homeostasis0.74168588
141MP0004145_abnormal_muscle_electrophysio0.73012578
142MP0000358_abnormal_cell_content/0.72890116
143MP0009703_decreased_birth_body0.72855398
144MP0004782_abnormal_surfactant_physiolog0.72653847
145MP0005646_abnormal_pituitary_gland0.71750324
146MP0001119_abnormal_female_reproductive0.71743387
147MP0000653_abnormal_sex_gland0.71622571
148MP0005410_abnormal_fertilization0.71541072
149MP0009764_decreased_sensitivity_to0.71500460
150MP0004085_abnormal_heartbeat0.68675110
151MP0002653_abnormal_ependyma_morphology0.68128774
152MP0004924_abnormal_behavior0.68013498
153MP0005386_behavior/neurological_phenoty0.68013498
154MP0005195_abnormal_posterior_eye0.66556877
155MP0005671_abnormal_response_to0.65503967
156MP0004084_abnormal_cardiac_muscle0.64933652
157MP0001853_heart_inflammation0.64633989
158MP0009333_abnormal_splenocyte_physiolog0.64044317
159MP0001919_abnormal_reproductive_system0.63674682
160MP0000749_muscle_degeneration0.63490332
161MP0002229_neurodegeneration0.63302563
162MP0002751_abnormal_autonomic_nervous0.62949575
163MP0001929_abnormal_gametogenesis0.62169908
164MP0005389_reproductive_system_phenotype0.60295305
165MP0002269_muscular_atrophy0.57298686
166MP0005384_cellular_phenotype0.56588468
167MP0002127_abnormal_cardiovascular_syste0.54916322
168MP0010329_abnormal_lipoprotein_level0.54882225
169MP0009765_abnormal_xenobiotic_induced0.54446710

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the anterior horn cell (HP:0006802)3.76351567
2Degeneration of anterior horn cells (HP:0002398)3.76351567
3Type II lissencephaly (HP:0007260)3.74192797
4Birth length less than 3rd percentile (HP:0003561)3.71835859
5Abnormality of aromatic amino acid family metabolism (HP:0004338)3.56104986
6Hypobetalipoproteinemia (HP:0003563)3.55182365
7Abnormality of pyrimidine metabolism (HP:0004353)3.48725335
8Pancreatic cysts (HP:0001737)3.38035811
9Carpal bone hypoplasia (HP:0001498)3.06062904
10Pancreatic fibrosis (HP:0100732)3.03151992
11Abnormality of glycolysis (HP:0004366)3.02287778
12Increased serum pyruvate (HP:0003542)3.02287778
13Hypoglycemic coma (HP:0001325)3.02161771
14Hepatic necrosis (HP:0002605)3.01985098
15Irregular epiphyses (HP:0010582)2.98799801
16Chromsome breakage (HP:0040012)2.96909072
17True hermaphroditism (HP:0010459)2.91076935
18Methylmalonic acidemia (HP:0002912)2.90168604
19Acute necrotizing encephalopathy (HP:0006965)2.87979741
20Renal cortical cysts (HP:0000803)2.86767112
21Cerebellar dysplasia (HP:0007033)2.84818396
22Decreased electroretinogram (ERG) amplitude (HP:0000654)2.84138249
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.80590485
24Retinal dysplasia (HP:0007973)2.78381277
25Intrahepatic cholestasis (HP:0001406)2.78086097
26Increased CSF lactate (HP:0002490)2.78061488
27Breast hypoplasia (HP:0003187)2.77533409
28Increased serum lactate (HP:0002151)2.75201486
29Hepatocellular necrosis (HP:0001404)2.72991172
30Abnormal mitochondria in muscle tissue (HP:0008316)2.70362793
31Medial flaring of the eyebrow (HP:0010747)2.69926437
32Abnormality of monocarboxylic acid metabolism (HP:0010996)2.69452256
33Congenital stationary night blindness (HP:0007642)2.68695294
34Pancreatic islet-cell hyperplasia (HP:0004510)2.68258027
35Mitochondrial inheritance (HP:0001427)2.67965736
36Acute encephalopathy (HP:0006846)2.67933579
37Cerebral edema (HP:0002181)2.64979326
38Decreased central vision (HP:0007663)2.64899575
39Lipid accumulation in hepatocytes (HP:0006561)2.64561972
40Exertional dyspnea (HP:0002875)2.63740602
41Prolonged partial thromboplastin time (HP:0003645)2.63074168
42Cerebral hypomyelination (HP:0006808)2.61835060
43Autoamputation (HP:0001218)2.58916351
44Abnormality of the renal cortex (HP:0011035)2.55745984
45Progressive inability to walk (HP:0002505)2.55425330
46Increased intramyocellular lipid droplets (HP:0012240)2.52898090
473-Methylglutaconic aciduria (HP:0003535)2.51624344
48Inability to walk (HP:0002540)2.48882723
49Increased hepatocellular lipid droplets (HP:0006565)2.48273164
50Patellar aplasia (HP:0006443)2.47488217
51Type I transferrin isoform profile (HP:0003642)2.46981478
52Abnormality of midbrain morphology (HP:0002418)2.45592528
53Molar tooth sign on MRI (HP:0002419)2.45592528
54Congenital, generalized hypertrichosis (HP:0004540)2.44255316
55Nephronophthisis (HP:0000090)2.37661004
56Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.35490505
57Abnormality of glycine metabolism (HP:0010895)2.34971584
58Abnormality of serine family amino acid metabolism (HP:0010894)2.34971584
59Reticulocytopenia (HP:0001896)2.34821224
60Hyperglycinuria (HP:0003108)2.32180158
61Lissencephaly (HP:0001339)2.31934399
62Abnormality of alanine metabolism (HP:0010916)2.31786531
63Hyperalaninemia (HP:0003348)2.31786531
64Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.31786531
65Oral leukoplakia (HP:0002745)2.30404908
66Abolished electroretinogram (ERG) (HP:0000550)2.30225960
67Abnormality of the ileum (HP:0001549)2.30096387
68Hypothermia (HP:0002045)2.28834986
69Vitreoretinal degeneration (HP:0000655)2.28138893
70Aplasia/Hypoplasia of the patella (HP:0006498)2.24320707
71Hyperglycinemia (HP:0002154)2.24207644
72Optic disc pallor (HP:0000543)2.24133050
73Respiratory difficulties (HP:0002880)2.22222229
74Hypoglycemic seizures (HP:0002173)2.22208612
75Increased corneal curvature (HP:0100692)2.20555781
76Keratoconus (HP:0000563)2.20555781
77Microvesicular hepatic steatosis (HP:0001414)2.20397188
78Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18627519
79Abnormality of methionine metabolism (HP:0010901)2.18102349
80Methylmalonic aciduria (HP:0012120)2.17007409
81Congenital primary aphakia (HP:0007707)2.16431717
82Meckel diverticulum (HP:0002245)2.16322504
83Microretrognathia (HP:0000308)2.15842014
84Hyperventilation (HP:0002883)2.15268113
85Abnormality of chromosome stability (HP:0003220)2.13000061
86Lactic acidosis (HP:0003128)2.12440792
87Gait imbalance (HP:0002141)2.10073542
88Increased muscle lipid content (HP:0009058)2.09519934
89Selective tooth agenesis (HP:0001592)2.09144068
90Pachygyria (HP:0001302)2.09139092
91Decreased activity of mitochondrial respiratory chain (HP:0008972)2.08872490
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.08872490
93Abnormality of the pancreatic islet cells (HP:0006476)2.08857691
94Abnormality of endocrine pancreas physiology (HP:0012093)2.08857691
95CNS demyelination (HP:0007305)2.08159278
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07025971
97Megaloblastic anemia (HP:0001889)2.05998460
98Abnormality of the preputium (HP:0100587)2.05056425
99Abnormality of serum amino acid levels (HP:0003112)2.05012550
100Delayed CNS myelination (HP:0002188)2.04957290
101Generalized aminoaciduria (HP:0002909)2.04675476
102Abnormality of the heme biosynthetic pathway (HP:0010472)2.03201413
103Nephrogenic diabetes insipidus (HP:0009806)2.03187515
104Abnormality of the renal medulla (HP:0100957)2.03120868
105Poor speech (HP:0002465)2.02525182
106Aplasia/hypoplasia of the uterus (HP:0008684)2.02514321
107Attenuation of retinal blood vessels (HP:0007843)2.01041890
108Fair hair (HP:0002286)1.99687449
109Aplasia/Hypoplasia of the tongue (HP:0010295)1.99594893
110Hypochromic microcytic anemia (HP:0004840)1.99540611
111Short tibia (HP:0005736)1.99521591
112Hypolipoproteinemia (HP:0010981)1.98035090
113Aplastic anemia (HP:0001915)1.97859057
114Neoplasm of the adrenal gland (HP:0100631)1.95967966
115Absent radius (HP:0003974)1.95935056
116Hyperbilirubinemia (HP:0002904)1.95736109
117Progressive macrocephaly (HP:0004481)1.95384195
118Opisthotonus (HP:0002179)1.95299123
119Fat malabsorption (HP:0002630)1.91853293
120Abnormality of urine glucose concentration (HP:0011016)1.91688180
121Glycosuria (HP:0003076)1.91688180
122Aplasia/Hypoplasia of the tibia (HP:0005772)1.91276240
123Absent epiphyses (HP:0010577)1.90488625
124Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.90488625
125Optic nerve hypoplasia (HP:0000609)1.89969034
126Hyperammonemia (HP:0001987)1.89849187
127Aplasia/Hypoplasia of the uvula (HP:0010293)1.89668780
128Diastasis recti (HP:0001540)1.88706840
129Nausea (HP:0002018)1.88565349
130Abnormal number of incisors (HP:0011064)1.87530999
131Leukodystrophy (HP:0002415)1.87480931
132Enlarged kidneys (HP:0000105)1.87397888
133Hypoplasia of the fovea (HP:0007750)1.87069637
134Aplasia/Hypoplasia of the fovea (HP:0008060)1.87069637
135Rough bone trabeculation (HP:0100670)1.86698272
136Abnormality of renal resorption (HP:0011038)1.86395173
137Lethargy (HP:0001254)1.86259173
138Pendular nystagmus (HP:0012043)1.86054320
139Abnormal rod and cone electroretinograms (HP:0008323)1.85941472
140Abnormality of macular pigmentation (HP:0008002)1.85718503
141Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84880488
142Aplasia involving forearm bones (HP:0009822)1.84209029
143Absent forearm bone (HP:0003953)1.84209029
144Respiratory failure (HP:0002878)1.83925531
145Colon cancer (HP:0003003)1.83623140
146Duplicated collecting system (HP:0000081)1.83581398
147Exercise intolerance (HP:0003546)1.83545959
148Abnormal lung lobation (HP:0002101)1.83218769
149Abnormality of sulfur amino acid metabolism (HP:0004339)1.81705561
150Stomach cancer (HP:0012126)1.81411875
151Bone marrow hypocellularity (HP:0005528)1.80732547
152Abnormality of vitamin B metabolism (HP:0004340)1.80237942
153Abnormality of the fovea (HP:0000493)1.79666841
154Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79388026
155Steatorrhea (HP:0002570)1.79002758
156Hyperinsulinemic hypoglycemia (HP:0000825)1.78610122
157Renal Fanconi syndrome (HP:0001994)1.78210310
158Abnormal protein glycosylation (HP:0012346)1.77067379
159Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77067379
16011 pairs of ribs (HP:0000878)1.76764649
161Abnormal glycosylation (HP:0012345)1.76686512
162Abnormal protein N-linked glycosylation (HP:0012347)1.76686512
163Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76527676

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.57406109
2PASK4.22846983
3STK163.67627110
4TRIM283.16426922
5EIF2AK13.05542981
6CDC73.04612389
7WEE12.95105431
8NUAK12.83231447
9VRK22.80822021
10BRSK22.69038762
11SRPK12.42124294
12BMPR1B2.41149052
13FRK2.39227993
14EIF2AK32.30718249
15ACVR1B2.22016448
16BCKDK1.92938582
17PBK1.92748215
18NEK11.92131595
19ADRBK21.89340880
20PLK41.87655907
21TESK21.83683635
22MKNK11.80552281
23CASK1.74258064
24VRK11.71433436
25MAP3K121.70653025
26TTK1.68484424
27ZAK1.67663137
28TAOK31.67384504
29BCR1.65227604
30TSSK61.65061992
31BRAF1.61113737
32STK38L1.52821804
33GRK11.52597302
34PLK11.51509169
35FLT31.45516654
36MKNK21.42030166
37BRSK11.41496382
38PLK31.39560256
39MAP3K41.38490463
40TAF11.38255038
41PIM21.37179471
42MST41.32986367
43ATR1.32026935
44AURKA1.30157302
45AKT31.30029248
46LIMK11.29332243
47SIK31.29245776
48TLK11.29072304
49OBSCN1.22334960
50TESK11.21149407
51AURKB1.20725503
52CAMKK21.19436481
53PINK11.19432157
54TXK1.19111097
55PLK21.09855429
56WNK41.08650015
57CSNK1G21.07551255
58CHEK21.06199615
59STK101.03287981
60CDK71.02968218
61CSNK1G11.00885440
62MAP3K111.00389818
63NME20.97953698
64MAP2K70.97814274
65CDK80.94694653
66NEK20.94511865
67TNIK0.93769780
68EIF2AK20.91346595
69PDK40.88861489
70PDK30.88861489
71KDR0.87747289
72OXSR10.86243130
73CHEK10.84577804
74TAOK20.82612390
75STK390.82409407
76MARK30.79190504
77MAPKAPK30.78569551
78RPS6KA40.78132137
79MAP4K20.77061738
80IRAK30.75848712
81CDK40.75208303
82SCYL20.74938750
83CSNK1A1L0.74496938
84MAPK130.73853383
85PHKG10.73728160
86PHKG20.73728160
87ATM0.70886312
88PRKCE0.69335378
89STK240.66893606
90RPS6KB20.66323841
91STK30.64186728
92CCNB10.63569580
93PDK20.62409887
94MAP3K50.62029629
95PAK30.61748322
96MAP3K60.61356919
97CSNK2A10.61057767
98YES10.60802780
99DYRK20.59574823
100TEC0.58486114
101CSNK2A20.58429848
102IRAK40.57537473
103GRK50.57514299
104ERBB30.57118140
105DAPK10.57066232
106PIM10.56848952
107MAP3K80.55170744
108FER0.54039773
109STK40.53460676
110MELK0.53416662
111PRKCG0.53396178
112ABL20.53340340
113ERN10.52491712
114MARK10.51196236
115CDK20.50760149
116CDK10.50623121
117NME10.50169962
118INSRR0.50128001
119MAP3K140.49420553
120ADRBK10.48923801
121DYRK30.48626326
122TGFBR10.47777756
123MAP2K30.47512015
124GRK70.45957626
125WNK30.43760596
126CDK120.42285765
127IGF1R0.37490244
128RPS6KB10.35832031
129PRKG10.35663066
130ARAF0.34493706
131EPHA20.34237591
132PIK3CA0.33855857
133PRKCQ0.32728397
134PAK40.32090091
135RPS6KA50.31367148
136PIK3CG0.29853343
137BMPR20.29672360
138CAMK2A0.29528231
139PAK10.29420896
140CDK30.28510074
141MAPKAPK50.28457398
142NEK90.27687586
143PRKCI0.27425287
144EPHA30.27317649
145ABL10.27256140
146IKBKB0.26905785
147CLK10.26854801
148CSNK1D0.26664245
149CSNK1G30.25916161
150CSNK1A10.25760482
151BRD40.25694045
152ERBB40.25394532
153CDK60.24968915
154MET0.24488932
155MYLK0.24159587
156NEK60.24034096
157IRAK10.23132340

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.66683229
2DNA replication_Homo sapiens_hsa030303.42583222
3Mismatch repair_Homo sapiens_hsa034303.12482277
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.62508983
5RNA polymerase_Homo sapiens_hsa030202.56186468
6Protein export_Homo sapiens_hsa030602.51239112
7Base excision repair_Homo sapiens_hsa034102.34451985
8One carbon pool by folate_Homo sapiens_hsa006702.31981189
9Nucleotide excision repair_Homo sapiens_hsa034202.16069967
10Spliceosome_Homo sapiens_hsa030402.09389536
11Pyrimidine metabolism_Homo sapiens_hsa002402.06169809
12Homologous recombination_Homo sapiens_hsa034402.04834212
13RNA transport_Homo sapiens_hsa030132.02363353
14Folate biosynthesis_Homo sapiens_hsa007901.96720546
15Ribosome_Homo sapiens_hsa030101.94211413
16Cell cycle_Homo sapiens_hsa041101.93790481
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91408553
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90363462
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.85696476
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.80786413
21Caffeine metabolism_Homo sapiens_hsa002321.76261467
22Basal transcription factors_Homo sapiens_hsa030221.71472683
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66046983
24Phototransduction_Homo sapiens_hsa047441.65428767
25Non-homologous end-joining_Homo sapiens_hsa034501.58855531
26Steroid biosynthesis_Homo sapiens_hsa001001.58241740
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.53927006
28Selenocompound metabolism_Homo sapiens_hsa004501.50023051
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47329194
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.46248586
31Fanconi anemia pathway_Homo sapiens_hsa034601.41756821
32Biosynthesis of amino acids_Homo sapiens_hsa012301.37163022
33RNA degradation_Homo sapiens_hsa030181.36039860
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.35374663
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29518482
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.28283589
37Parkinsons disease_Homo sapiens_hsa050121.25671369
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24072480
39Oxidative phosphorylation_Homo sapiens_hsa001901.22388304
40Peroxisome_Homo sapiens_hsa041461.17718114
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13704525
42Carbon metabolism_Homo sapiens_hsa012001.13087698
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10649386
44p53 signaling pathway_Homo sapiens_hsa041151.08468704
45Fatty acid elongation_Homo sapiens_hsa000621.07950627
46Huntingtons disease_Homo sapiens_hsa050161.03546318
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02848006
48Tryptophan metabolism_Homo sapiens_hsa003801.02742349
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01987260
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01200509
51Purine metabolism_Homo sapiens_hsa002301.00276045
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00223371
53Pyruvate metabolism_Homo sapiens_hsa006200.98404650
54Pentose phosphate pathway_Homo sapiens_hsa000300.97544085
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94020253
56Arginine and proline metabolism_Homo sapiens_hsa003300.90312796
57Glutathione metabolism_Homo sapiens_hsa004800.88582314
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87060193
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87033946
60mRNA surveillance pathway_Homo sapiens_hsa030150.86346727
61Collecting duct acid secretion_Homo sapiens_hsa049660.85897582
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84965715
63Fatty acid degradation_Homo sapiens_hsa000710.84016115
64Retinol metabolism_Homo sapiens_hsa008300.83447011
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.83243840
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81708497
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79809922
68Tyrosine metabolism_Homo sapiens_hsa003500.78056895
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77804840
70Arginine biosynthesis_Homo sapiens_hsa002200.77717439
71Cardiac muscle contraction_Homo sapiens_hsa042600.77599650
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77499199
73Propanoate metabolism_Homo sapiens_hsa006400.76087763
74Vitamin B6 metabolism_Homo sapiens_hsa007500.73093515
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72625945
76Metabolic pathways_Homo sapiens_hsa011000.72455189
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70233840
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68797242
79Epstein-Barr virus infection_Homo sapiens_hsa051690.68076816
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67977894
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63932800
82Histidine metabolism_Homo sapiens_hsa003400.62611590
83Circadian rhythm_Homo sapiens_hsa047100.62380338
84Asthma_Homo sapiens_hsa053100.61708098
85Complement and coagulation cascades_Homo sapiens_hsa046100.61469714
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61065456
87Ether lipid metabolism_Homo sapiens_hsa005650.60903046
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59846292
89Sulfur metabolism_Homo sapiens_hsa009200.59482187
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59135888
91Phenylalanine metabolism_Homo sapiens_hsa003600.57962448
92Type I diabetes mellitus_Homo sapiens_hsa049400.56881612
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56012458
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.55748337
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55355638
96Sulfur relay system_Homo sapiens_hsa041220.54915014
97Chemical carcinogenesis_Homo sapiens_hsa052040.54871895
98Butanoate metabolism_Homo sapiens_hsa006500.52166883
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.51727695
100Fatty acid metabolism_Homo sapiens_hsa012120.51717734
101Nicotine addiction_Homo sapiens_hsa050330.50791619
102Glycerolipid metabolism_Homo sapiens_hsa005610.48057779
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47757562
104N-Glycan biosynthesis_Homo sapiens_hsa005100.46391265
105beta-Alanine metabolism_Homo sapiens_hsa004100.45860592
106Fructose and mannose metabolism_Homo sapiens_hsa000510.42664777
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42134210
108Oocyte meiosis_Homo sapiens_hsa041140.41926563
109Nitrogen metabolism_Homo sapiens_hsa009100.41664760
110Vitamin digestion and absorption_Homo sapiens_hsa049770.41616691
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41278367
112Alzheimers disease_Homo sapiens_hsa050100.40343379
113Arachidonic acid metabolism_Homo sapiens_hsa005900.40295025
114Starch and sucrose metabolism_Homo sapiens_hsa005000.39102618
115Galactose metabolism_Homo sapiens_hsa000520.37791882
116Linoleic acid metabolism_Homo sapiens_hsa005910.37225246
117Olfactory transduction_Homo sapiens_hsa047400.37196904
118Primary immunodeficiency_Homo sapiens_hsa053400.36856271
119Systemic lupus erythematosus_Homo sapiens_hsa053220.35401466
120Regulation of autophagy_Homo sapiens_hsa041400.33249602
121Fat digestion and absorption_Homo sapiens_hsa049750.31681789
122Mineral absorption_Homo sapiens_hsa049780.29676378
123Serotonergic synapse_Homo sapiens_hsa047260.29243961
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28850307
125Graft-versus-host disease_Homo sapiens_hsa053320.27616203
126Herpes simplex infection_Homo sapiens_hsa051680.27249011

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