RABL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Ras superfamily of small GTPases. The encoded protein binds to both GTP and GDP and may play a role in cell growth and survival. Overexpression of this gene may play a role in breast cancer tumorigenesis, and pseudogenes of this gene are located on the long arm of chromosome 2 and the short arm of chromosome 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GDP-mannose metabolic process (GO:0019673)8.34647523
2cellular response to ATP (GO:0071318)8.26884649
3adenine nucleotide transport (GO:0051503)7.65779959
4DNA strand renaturation (GO:0000733)7.65045799
5adenosine receptor signaling pathway (GO:0001973)7.59371570
6purine ribonucleotide transport (GO:0015868)6.76145525
7meiotic chromosome segregation (GO:0045132)6.68935398
8negative regulation of cell aging (GO:0090344)6.29940474
9positive regulation of protein kinase C signaling (GO:0090037)6.17862532
10purine nucleotide transport (GO:0015865)6.15486494
11UV protection (GO:0009650)5.65304413
12G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.59466865
13rRNA methylation (GO:0031167)5.38892139
14nucleoside transmembrane transport (GO:1901642)5.19795218
15sensory perception of taste (GO:0050909)5.13725940
16purinergic nucleotide receptor signaling pathway (GO:0035590)4.90932345
17synaptic vesicle maturation (GO:0016188)4.83381860
18regulation of short-term neuronal synaptic plasticity (GO:0048172)4.74439163
19lens fiber cell differentiation (GO:0070306)4.74225944
20locomotory exploration behavior (GO:0035641)4.72456911
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.70929103
22histone phosphorylation (GO:0016572)4.67108099
23melanin biosynthetic process (GO:0042438)4.65758036
24regulation of skeletal muscle contraction (GO:0014819)4.60835082
25rRNA modification (GO:0000154)4.54266808
26response to ATP (GO:0033198)4.50405443
27urinary tract smooth muscle contraction (GO:0014848)4.47202958
28ribosomal small subunit biogenesis (GO:0042274)4.38482453
29melanin metabolic process (GO:0006582)4.24389436
30regulation of translational fidelity (GO:0006450)4.21221819
31mannose metabolic process (GO:0006013)4.18786321
32sex determination (GO:0007530)4.13463418
33positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.07200209
34peptidyl-glutamic acid carboxylation (GO:0017187)3.97911836
35protein carboxylation (GO:0018214)3.97911836
36nucleoside transport (GO:0015858)3.97708287
37nucleotide transmembrane transport (GO:1901679)3.95362343
38purinergic receptor signaling pathway (GO:0035587)3.93982851
39G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.88342178
40nucleotide-sugar biosynthetic process (GO:0009226)3.86853344
41proline biosynthetic process (GO:0006561)3.86597567
42vocalization behavior (GO:0071625)3.83377035
43sodium ion export (GO:0071436)3.79123704
44cellular potassium ion homeostasis (GO:0030007)3.78420872
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.75712106
46DNA replication checkpoint (GO:0000076)3.72221819
47neuronal action potential propagation (GO:0019227)3.71970642
48cytoskeletal anchoring at plasma membrane (GO:0007016)3.71291848
49regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.70458134
50layer formation in cerebral cortex (GO:0021819)3.70203254
51regulation of protein kinase A signaling (GO:0010738)3.68904833
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.67405670
53purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.64007053
54ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.64007053
55nucleoside bisphosphate biosynthetic process (GO:0033866)3.64007053
56peristalsis (GO:0030432)3.63171636
57regulation of synapse structural plasticity (GO:0051823)3.62609640
58negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.59179699
59activation of protein kinase A activity (GO:0034199)3.58696456
60planar cell polarity pathway involved in neural tube closure (GO:0090179)3.56977855
61synaptic vesicle exocytosis (GO:0016079)3.54010201
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.53584895
63glutamate secretion (GO:0014047)3.53028047
64regulation of hydrogen peroxide metabolic process (GO:0010310)3.52363176
65synaptic vesicle docking involved in exocytosis (GO:0016081)3.52008901
66regulation of glutamate receptor signaling pathway (GO:1900449)3.48924711
67cell communication by electrical coupling (GO:0010644)3.47730747
68plasma membrane repair (GO:0001778)3.47537132
69G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.44894886
70dendritic spine morphogenesis (GO:0060997)3.41906919
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.41276943
72folic acid metabolic process (GO:0046655)3.39807483
73gonadal mesoderm development (GO:0007506)3.38980298
74regulation of synaptic vesicle exocytosis (GO:2000300)3.37701556
75regulation of cell aging (GO:0090342)3.34871151
76neuronal ion channel clustering (GO:0045161)3.32528384
77protein retention in ER lumen (GO:0006621)3.32278656
78secondary metabolite biosynthetic process (GO:0044550)3.28879924
79regulation of neuronal synaptic plasticity (GO:0048168)3.28764620
80potassium ion import (GO:0010107)3.23601791
81neuromuscular process controlling balance (GO:0050885)3.21499790
82exploration behavior (GO:0035640)3.21169476
83semaphorin-plexin signaling pathway (GO:0071526)3.19379033
84modulation by virus of host process (GO:0019054)3.17184466
85regulation of long-term neuronal synaptic plasticity (GO:0048169)3.16236335
86G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.13819642
87neuromuscular synaptic transmission (GO:0007274)3.13782539
88regulation of mammary gland epithelial cell proliferation (GO:0033599)3.12786330
89regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.12528788
90regulation of ARF protein signal transduction (GO:0032012)3.12160749
91protein insertion into membrane (GO:0051205)3.10966392
92peptidyl-lysine dimethylation (GO:0018027)3.10797147
93regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.07617526
94regulation of dendritic spine morphogenesis (GO:0061001)3.04756292
95neurotransmitter secretion (GO:0007269)3.04427558
96ionotropic glutamate receptor signaling pathway (GO:0035235)3.03799093
97negative regulation of cell size (GO:0045792)2.99137620
98long-term memory (GO:0007616)2.99056787
99actin filament bundle organization (GO:0061572)2.98616158
100actin filament bundle assembly (GO:0051017)2.98616158
101maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.97365546
102negative regulation of cytosolic calcium ion concentration (GO:0051481)2.96216227
103DNA duplex unwinding (GO:0032508)2.95719433
104positive regulation of synapse maturation (GO:0090129)2.95560674
105mating behavior (GO:0007617)2.94016405
106proline metabolic process (GO:0006560)2.93579984
107vesicle transport along microtubule (GO:0047496)2.93017989
108membrane depolarization during action potential (GO:0086010)2.92461826
109membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.90846112
110cerebellar Purkinje cell differentiation (GO:0021702)2.90819046
111regulation of synaptic vesicle transport (GO:1902803)2.90329471
112establishment of nucleus localization (GO:0040023)2.89358400
113regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.88866625
114membrane repolarization (GO:0086009)2.88272931
115regulation of nuclear cell cycle DNA replication (GO:0033262)2.88199748
116glycine transport (GO:0015816)2.87733769
117protein localization to synapse (GO:0035418)2.87466754
118potassium ion homeostasis (GO:0055075)2.87461820
119focal adhesion assembly (GO:0048041)2.86292254
120cell-substrate adherens junction assembly (GO:0007045)2.86292254
121purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.85862887
1223-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.85862887
123dendritic spine organization (GO:0097061)2.83299438
124positive regulation of catecholamine secretion (GO:0033605)2.83169726
125negative regulation of potassium ion transmembrane transport (GO:1901380)2.83026580
126regulation of protein kinase C signaling (GO:0090036)2.81552835
127transmission of nerve impulse (GO:0019226)2.79541942
128dendrite morphogenesis (GO:0048813)2.79266523
129grooming behavior (GO:0007625)2.78886486
130endocytic recycling (GO:0032456)2.78849049
131negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.78050463
132tRNA modification (GO:0006400)2.77625787
133cell-cell junction maintenance (GO:0045217)2.77552948
134synaptic transmission, glutamatergic (GO:0035249)2.77103794
135cell communication involved in cardiac conduction (GO:0086065)2.76732369
136cerebellar Purkinje cell layer development (GO:0021680)2.76175569
137regulation of ARF GTPase activity (GO:0032312)2.76099391
138regulation of calcium ion transmembrane transport (GO:1903169)2.76079572
139regulation of calcium ion transmembrane transporter activity (GO:1901019)2.76079572
140positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.75438333
141regulation of membrane repolarization (GO:0060306)2.74935011
142prepulse inhibition (GO:0060134)2.73110717
143modulation by symbiont of host cellular process (GO:0044068)2.72442256
144DNA geometric change (GO:0032392)2.71979751
145chemosensory behavior (GO:0007635)2.71802341
146cellular response to virus (GO:0098586)2.71776642
147positive regulation of membrane potential (GO:0045838)2.70326470
148regulation of fatty acid beta-oxidation (GO:0031998)2.69478098
149regulation of excitatory postsynaptic membrane potential (GO:0060079)2.69325458
150anatomical structure regression (GO:0060033)2.67426288
151sialylation (GO:0097503)2.67420296
152very-low-density lipoprotein particle assembly (GO:0034379)2.66862148
153regulation of synaptic plasticity (GO:0048167)2.66845238
154diacylglycerol metabolic process (GO:0046339)2.66534592
155positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.66339374
156phosphate ion transmembrane transport (GO:0035435)2.66171435
157membrane repolarization during action potential (GO:0086011)2.66062239
158positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.66051335
159regulation of cholesterol biosynthetic process (GO:0045540)2.65926125
160glutamate receptor signaling pathway (GO:0007215)2.65874207
161negative regulation of catenin import into nucleus (GO:0035414)2.64600789
162neuron-neuron synaptic transmission (GO:0007270)2.64075857
163adherens junction assembly (GO:0034333)2.63474422
164nucleotide transport (GO:0006862)2.62543442
165suckling behavior (GO:0001967)2.61536122
166negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.60097535
167detection of calcium ion (GO:0005513)2.57449860
168basement membrane organization (GO:0071711)2.57436678
169regulation of postsynaptic membrane potential (GO:0060078)2.57264364
170positive regulation of potassium ion transmembrane transport (GO:1901381)2.57155488
171neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.56561974
172synaptic vesicle endocytosis (GO:0048488)2.54691363
173trivalent inorganic anion homeostasis (GO:0072506)2.53475213
174phosphate ion homeostasis (GO:0055062)2.53475213
175regulation of Rap GTPase activity (GO:0032317)2.53461492
176peptidyl-threonine phosphorylation (GO:0018107)2.53109560
177regulation of early endosome to late endosome transport (GO:2000641)2.52185414
178activation of Rac GTPase activity (GO:0032863)2.51700284
179neuromuscular process controlling posture (GO:0050884)2.51430901
180cell migration in hindbrain (GO:0021535)2.50775097
181positive regulation of dendritic spine development (GO:0060999)2.50549589
182positive regulation of dendritic spine morphogenesis (GO:0061003)2.49781495
183neuromuscular junction development (GO:0007528)2.48397046
184regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.47855970
185organelle transport along microtubule (GO:0072384)2.46704771
186positive regulation of potassium ion transport (GO:0043268)2.46604776
187positive regulation of Rap GTPase activity (GO:0032854)2.46283026
188regulation of ion transmembrane transporter activity (GO:0032412)2.45863478
189negative regulation of organelle assembly (GO:1902116)2.45104636
190membrane depolarization (GO:0051899)2.45036583
191auditory behavior (GO:0031223)2.44711876
192regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.44113306
193regulation of vesicle fusion (GO:0031338)2.43935242
194striatum development (GO:0021756)2.43849351

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.53951418
2VDR_21846776_ChIP-Seq_THP-1_Human3.86486826
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.28117995
4RARB_27405468_Chip-Seq_BRAIN_Mouse3.11008374
5DROSHA_22980978_ChIP-Seq_HELA_Human2.89106186
6TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.74549926
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.56002119
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.55054779
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.48155378
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45665713
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45665713
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.37805916
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29437083
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27485790
15ZFP281_18757296_ChIP-ChIP_E14_Mouse2.24328473
16WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.16665363
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13863463
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.11751024
19KDM2B_26808549_Chip-Seq_K562_Human2.09856349
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.09060312
21DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.08963178
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.06460870
23REST_21632747_ChIP-Seq_MESCs_Mouse2.05854083
24STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04382490
25ERG_21242973_ChIP-ChIP_JURKAT_Human2.04345317
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.04046230
27TET1_21451524_ChIP-Seq_MESCs_Mouse2.03600320
28KDM2B_26808549_Chip-Seq_SUP-B15_Human2.02268698
29XRN2_22483619_ChIP-Seq_HELA_Human2.01225986
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.00583992
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00135017
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99493658
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.98093612
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97313132
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.96279671
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.96068179
37MAF_26560356_Chip-Seq_TH2_Human1.91179604
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90702649
39EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.90094804
40KDM2B_26808549_Chip-Seq_DND41_Human1.87155534
41CTCF_27219007_Chip-Seq_ERYTHROID_Human1.82754037
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.81776677
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.80669936
44BCOR_27268052_Chip-Seq_Bcells_Human1.80658660
45BCL6_27268052_Chip-Seq_Bcells_Human1.80583957
46VDR_24763502_ChIP-Seq_THP-1_Human1.79879130
47LXR_22292898_ChIP-Seq_THP-1_Human1.78371844
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77743051
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.75898751
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75546377
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.74719755
52E2F1_20622854_ChIP-Seq_HELA_Human1.64373422
53TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.62989254
54PHF8_20622854_ChIP-Seq_HELA_Human1.62275235
55DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.61193524
56MAF_26560356_Chip-Seq_TH1_Human1.60857382
57SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.59130922
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.58176648
59RARB_24833708_ChIP-Seq_LIVER_Mouse1.57759240
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.57741505
61SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56769967
62RARA_24833708_ChIP-Seq_LIVER_Mouse1.55600336
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.52126120
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49369302
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.48202162
66CTCF_27219007_Chip-Seq_Bcells_Human1.44016008
67FOXP1_21924763_ChIP-Seq_HESCs_Human1.43989660
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43354592
69ZNF263_19887448_ChIP-Seq_K562_Human1.42305823
70EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41642165
71TP63_17297297_ChIP-ChIP_HaCaT_Human1.37980353
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.37702375
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37123610
74SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36729928
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36452697
76NCOR1_26117541_ChIP-Seq_K562_Human1.36404600
77CREB1_26743006_Chip-Seq_LNCaP_Human1.33219370
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33160852
79GBX2_23144817_ChIP-Seq_PC3_Human1.32976913
80RXRA_24833708_ChIP-Seq_LIVER_Mouse1.31293190
81CTCF_21964334_Chip-Seq_Bcells_Human1.30969849
82ZNF274_21170338_ChIP-Seq_K562_Hela1.30779414
83E2F7_22180533_ChIP-Seq_HELA_Human1.30072110
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.29713214
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29373908
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29014468
87TP53_22127205_ChIP-Seq_IMR90_Human1.28897886
88ETS1_21867929_ChIP-Seq_TH2_Mouse1.28658546
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28474361
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27934160
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27020756
92SA1_27219007_Chip-Seq_Bcells_Human1.26204223
93AR_19668381_ChIP-Seq_PC3_Human1.25787679
94TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.25423665
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24374784
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22652288
97OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22041419
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21771951
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21639485
100ATF3_27146783_Chip-Seq_COLON_Human1.21592865
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.20856819
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20789568
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20727576
104PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20250345
105UTX_26944678_Chip-Seq_JUKART_Human1.20083900
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19913354
107CTCF_21964334_ChIP-Seq_BJAB-B_Human1.19752991
108ESR1_20079471_ChIP-ChIP_T-47D_Human1.19665565
109SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.19587428
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.18816194
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18256383
112SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17247137
113TCF7_22412390_ChIP-Seq_EML_Mouse1.16882031
114JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.16147215
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14495361
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14406889
117FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14068137
118RACK7_27058665_Chip-Seq_MCF-7_Human1.13146754
119SMC4_20622854_ChIP-Seq_HELA_Human1.12686869
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10615563
121CTCF_20526341_ChIP-Seq_ESCs_Human1.09434747
122CTCF_26484167_Chip-Seq_Bcells_Mouse1.09154737
123TET1_21490601_ChIP-Seq_MESCs_Mouse1.08882822
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08235035
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07854593
126PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06054699
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05611345
128P68_20966046_ChIP-Seq_HELA_Human1.04262211
129FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04261645
130EP300_21415370_ChIP-Seq_HL-1_Mouse1.03775556
131KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02161270
132EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.01920768
133SOX2_21211035_ChIP-Seq_LN229_Gbm1.01594952
134ISL1_27105846_Chip-Seq_CPCs_Mouse1.01075635
135AR_21572438_ChIP-Seq_LNCaP_Human1.00962372
136NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00832880
137NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.00823108
138NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99970515
139SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99051853
140KLF4_19829295_ChIP-Seq_ESCs_Human0.98422166
141ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98096953
142CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97691736
143MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96410363
144MYC_22102868_ChIP-Seq_BL_Human0.95877729
145SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95236499
146YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94233660
147RUNX1_27514584_Chip-Seq_MCF-7_Human0.93770209
148TBX20_22328084_ChIP-Seq_HEART_Mouse0.93317901
149TBX20_22080862_ChIP-Seq_HEART_Mouse0.93317901
150UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93107725
151ELK3_25401928_ChIP-Seq_HUVEC_Human0.92243290
152AHR_22903824_ChIP-Seq_MCF-7_Human0.91292645
153SA1_27219007_Chip-Seq_ERYTHROID_Human0.90955532
154SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90463882
155SMAD3_21741376_ChIP-Seq_ESCs_Human0.90358236
156TP53_23651856_ChIP-Seq_MEFs_Mouse0.90276663
157TP53_20018659_ChIP-ChIP_R1E_Mouse0.88549377
158TP63_22573176_ChIP-Seq_HFKS_Human0.88327790
159OCT4_19829295_ChIP-Seq_ESCs_Human0.88311218
160ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86523881

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation6.46217508
2MP0003136_yellow_coat_color6.18708998
3MP0004859_abnormal_synaptic_plasticity5.77058921
4MP0001986_abnormal_taste_sensitivity5.45296069
5MP0005174_abnormal_tail_pigmentation5.37379370
6MP0005409_darkened_coat_color5.06834670
7MP0001188_hyperpigmentation4.04773407
8MP0003635_abnormal_synaptic_transmissio3.17269052
9MP0004270_analgesia2.86962287
10MP0000751_myopathy2.80886095
11MP0004381_abnormal_hair_follicle2.73883830
12MP0004145_abnormal_muscle_electrophysio2.60945336
13MP0002822_catalepsy2.47987566
14MP0003880_abnormal_central_pattern2.43060319
15MP0002909_abnormal_adrenal_gland2.41229831
16MP0003283_abnormal_digestive_organ2.38261345
17MP0002063_abnormal_learning/memory/cond2.28256000
18MP0005083_abnormal_biliary_tract2.27883237
19MP0003111_abnormal_nucleus_morphology2.27661598
20MP0009745_abnormal_behavioral_response2.25761320
21MP0009780_abnormal_chondrocyte_physiolo2.25564357
22MP0002064_seizures2.17097284
23MP0000015_abnormal_ear_pigmentation2.12788604
24MP0002837_dystrophic_cardiac_calcinosis2.03374761
25MP0008961_abnormal_basal_metabolism1.96575156
26MP0009046_muscle_twitch1.94369101
27MP0003453_abnormal_keratinocyte_physiol1.93358464
28MP0004858_abnormal_nervous_system1.88468928
29MP0000747_muscle_weakness1.85066330
30MP0004233_abnormal_muscle_weight1.84115118
31MP0002272_abnormal_nervous_system1.82925115
32MP0008569_lethality_at_weaning1.74533143
33MP0001502_abnormal_circadian_rhythm1.72962595
34MP0002572_abnormal_emotion/affect_behav1.70779055
35MP0000013_abnormal_adipose_tissue1.69985569
36MP0001968_abnormal_touch/_nociception1.64335357
37MP0005423_abnormal_somatic_nervous1.59553220
38MP0001756_abnormal_urination1.56215650
39MP0001486_abnormal_startle_reflex1.55339980
40MP0002734_abnormal_mechanical_nocicepti1.55236042
41MP0005451_abnormal_body_composition1.50122009
42MP0003122_maternal_imprinting1.49703636
43MP0002234_abnormal_pharynx_morphology1.49490498
44MP0001440_abnormal_grooming_behavior1.49152745
45MP0002638_abnormal_pupillary_reflex1.49151175
46MP0004811_abnormal_neuron_physiology1.48102663
47MP0003693_abnormal_embryo_hatching1.46843343
48MP0004036_abnormal_muscle_relaxation1.44987781
49MP0004087_abnormal_muscle_fiber1.44749864
50MP0000955_abnormal_spinal_cord1.44107951
51MP0005058_abnormal_lysosome_morphology1.42317271
52MP0003329_amyloid_beta_deposits1.41989778
53MP0002269_muscular_atrophy1.41581452
54MP0000749_muscle_degeneration1.39181777
55MP0005623_abnormal_meninges_morphology1.38961603
56MP0000538_abnormal_urinary_bladder1.37782742
57MP0000678_abnormal_parathyroid_gland1.35712698
58MP0000003_abnormal_adipose_tissue1.34681767
59MP0002733_abnormal_thermal_nociception1.33480107
60MP0004084_abnormal_cardiac_muscle1.31036071
61MP0004885_abnormal_endolymph1.30536326
62MP0000759_abnormal_skeletal_muscle1.30473327
63MP0002067_abnormal_sensory_capabilities1.27950070
64MP0002184_abnormal_innervation1.27466049
65MP0004130_abnormal_muscle_cell1.26674928
66MP0010234_abnormal_vibrissa_follicle1.25877408
67MP0003705_abnormal_hypodermis_morpholog1.25704296
68MP0001970_abnormal_pain_threshold1.25385612
69MP0004957_abnormal_blastocyst_morpholog1.23760676
70MP0004215_abnormal_myocardial_fiber1.22795048
71MP0002106_abnormal_muscle_physiology1.22699695
72MP0001501_abnormal_sleep_pattern1.21684654
73MP0003137_abnormal_impulse_conducting1.20458493
74MP0002557_abnormal_social/conspecific_i1.18994583
75MP0004185_abnormal_adipocyte_glucose1.18960001
76MP0001348_abnormal_lacrimal_gland1.17431877
77MP0002249_abnormal_larynx_morphology1.16293214
78MP0005501_abnormal_skin_physiology1.14805921
79MP0009278_abnormal_bone_marrow1.14579721
80MP0001299_abnormal_eye_distance/1.14433378
81MP0003646_muscle_fatigue1.13378045
82MP0005386_behavior/neurological_phenoty1.13090844
83MP0004924_abnormal_behavior1.13090844
84MP0002066_abnormal_motor_capabilities/c1.11916518
85MP0004085_abnormal_heartbeat1.11837229
86MP0002882_abnormal_neuron_morphology1.10302636
87MP0003787_abnormal_imprinting1.09993470
88MP0000778_abnormal_nervous_system1.09396000
89MP0002736_abnormal_nociception_after1.09371765
90MP0005369_muscle_phenotype1.07289985
91MP0003045_fibrosis1.06135348
92MP0005375_adipose_tissue_phenotype1.05040666
93MP0005330_cardiomyopathy1.04613705
94MP0004043_abnormal_pH_regulation1.04542209
95MP0000569_abnormal_digit_pigmentation1.03594773
96MP0002152_abnormal_brain_morphology0.99037838
97MP0005620_abnormal_muscle_contractility0.98903617
98MP0003879_abnormal_hair_cell0.97696134
99MP0001849_ear_inflammation0.97676311
100MP0001664_abnormal_digestion0.95347499
101MP0000750_abnormal_muscle_regeneration0.93909152
102MP0003172_abnormal_lysosome_physiology0.93382016
103MP0003633_abnormal_nervous_system0.93024064
104MP0002735_abnormal_chemical_nociception0.92204048
105MP0000537_abnormal_urethra_morphology0.89714677
106MP0005584_abnormal_enzyme/coenzyme_acti0.85959843
107MP0002089_abnormal_postnatal_growth/wei0.85609010
108MP0003091_abnormal_cell_migration0.84441935
109MP0001661_extended_life_span0.84260581
110MP0003634_abnormal_glial_cell0.83393116
111MP0004484_altered_response_of0.83117122
112MP0010094_abnormal_chromosome_stability0.82134769
113MP0001958_emphysema0.81896313
114MP0009931_abnormal_skin_appearance0.81586403
115MP0004510_myositis0.80199020
116MP0001765_abnormal_ion_homeostasis0.79866243
117MP0005187_abnormal_penis_morphology0.79569828
118MP0002075_abnormal_coat/hair_pigmentati0.79449143
119MP0005666_abnormal_adipose_tissue0.79107656
120MP0005257_abnormal_intraocular_pressure0.78676939
121MP0005076_abnormal_cell_differentiation0.78597714
122MP0000534_abnormal_ureter_morphology0.77803526
123MP0000733_abnormal_muscle_development0.76760665
124MP0010630_abnormal_cardiac_muscle0.76093546
125MP0005645_abnormal_hypothalamus_physiol0.75812382
126MP0008770_decreased_survivor_rate0.75182346
127MP0005365_abnormal_bile_salt0.75120897
128MP0003077_abnormal_cell_cycle0.74423301
129MP0002796_impaired_skin_barrier0.73823536
130MP0003631_nervous_system_phenotype0.72474570
131MP0004142_abnormal_muscle_tone0.71032233
132MP0002069_abnormal_eating/drinking_beha0.70533587
133MP0002877_abnormal_melanocyte_morpholog0.70380448
134MP0001984_abnormal_olfaction0.69383935
135MP0000920_abnormal_myelination0.68681536
136MP0002229_neurodegeneration0.68420791
137MP0005167_abnormal_blood-brain_barrier0.68017465
138MP0001873_stomach_inflammation0.67647575
139MP0003861_abnormal_nervous_system0.67197910
140MP0010771_integument_phenotype0.65157679
141MP0005332_abnormal_amino_acid0.62070924
142MP0004197_abnormal_fetal_growth/weight/0.61151840
143MP0003123_paternal_imprinting0.60958669
144MP0000367_abnormal_coat/_hair0.60422718
145MP0001346_abnormal_lacrimal_gland0.58710512
146MP0004019_abnormal_vitamin_homeostasis0.58194001
147MP0002080_prenatal_lethality0.55803856
148MP0002019_abnormal_tumor_incidence0.54412723
149MP0001186_pigmentation_phenotype0.53901200
150MP0009840_abnormal_foam_cell0.52352700
151MP0000350_abnormal_cell_proliferation0.52230734
152MP0002086_abnormal_extraembryonic_tissu0.51955816
153MP0003303_peritoneal_inflammation0.51055639
154MP0005220_abnormal_exocrine_pancreas0.50373337
155MP0010386_abnormal_urinary_bladder0.50179573
156MP0003448_altered_tumor_morphology0.50156642
157MP0000358_abnormal_cell_content/0.49500798
158MP0003984_embryonic_growth_retardation0.49080496
159MP0001730_embryonic_growth_arrest0.47936185
160MP0010030_abnormal_orbit_morphology0.47216890
161MP0001672_abnormal_embryogenesis/_devel0.47013450
162MP0005380_embryogenesis_phenotype0.47013450
163MP0003115_abnormal_respiratory_system0.46688767
164MP0005621_abnormal_cell_physiology0.45997508
165MP0003632_abnormal_nervous_system0.44091002
166MP0002088_abnormal_embryonic_growth/wei0.43934743
167MP0000470_abnormal_stomach_morphology0.41057161
168MP0001216_abnormal_epidermal_layer0.41026032

Predicted human phenotypes

RankGene SetZ-score
1Ulnar bowing (HP:0003031)6.15265718
2Rib fusion (HP:0000902)5.86311646
3Thin bony cortex (HP:0002753)5.46081122
4Rectovaginal fistula (HP:0000143)5.30981683
5Rectal fistula (HP:0100590)5.30981683
6Intestinal fistula (HP:0100819)5.29453520
7Testicular atrophy (HP:0000029)5.18863817
8Vaginal fistula (HP:0004320)5.17650928
9Poikiloderma (HP:0001029)5.09710469
10Facial hemangioma (HP:0000329)4.73481965
11Coronal craniosynostosis (HP:0004440)4.67167796
12Myokymia (HP:0002411)4.24227122
13Focal motor seizures (HP:0011153)3.95288157
14Visual hallucinations (HP:0002367)3.79009953
15Akinesia (HP:0002304)3.75245030
16Anteriorly placed anus (HP:0001545)3.74774638
17Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.63640304
18Squamous cell carcinoma (HP:0002860)3.51636824
19Focal seizures (HP:0007359)3.49744944
20Popliteal pterygium (HP:0009756)3.46869237
21Short chin (HP:0000331)3.43536922
22Delayed epiphyseal ossification (HP:0002663)3.42676321
23Myopathic facies (HP:0002058)3.27137994
24Bowed forearm bones (HP:0003956)3.27098379
25Bowing of the arm (HP:0006488)3.27098379
26Male infertility (HP:0003251)3.17648855
27Patellar aplasia (HP:0006443)3.16478027
28Choanal stenosis (HP:0000452)3.16251364
29Insomnia (HP:0100785)3.15743486
30Abnormality of the intrinsic pathway (HP:0010989)3.13273472
31Fetal akinesia sequence (HP:0001989)3.05905236
32Aplasia of the musculature (HP:0100854)3.05364311
33Congenital stationary night blindness (HP:0007642)3.02629413
34Hemorrhage of the eye (HP:0011885)3.02237507
35Exercise-induced myalgia (HP:0003738)2.99281691
36Capillary hemangiomas (HP:0005306)2.97975616
37Sudden death (HP:0001699)2.94851693
38Aplasia/Hypoplasia of the patella (HP:0006498)2.92596613
39Birth length less than 3rd percentile (HP:0003561)2.88333574
40Ankle clonus (HP:0011448)2.86967363
41Bundle branch block (HP:0011710)2.83340438
42Action tremor (HP:0002345)2.81332837
43Thin ribs (HP:0000883)2.79769947
44Hyperacusis (HP:0010780)2.79680822
45Joint stiffness (HP:0001387)2.79512164
46Supranuclear gaze palsy (HP:0000605)2.74759562
47Attenuation of retinal blood vessels (HP:0007843)2.72457289
48Ventricular fibrillation (HP:0001663)2.70331555
49Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.69086543
50Pointed chin (HP:0000307)2.65901265
51Dysmetric saccades (HP:0000641)2.64842525
52Breast hypoplasia (HP:0003187)2.63439295
53Depression (HP:0000716)2.59212200
54Resting tremor (HP:0002322)2.59153771
55Difficulty running (HP:0009046)2.58532304
56Exercise-induced muscle cramps (HP:0003710)2.55924787
57Muscle hypertrophy of the lower extremities (HP:0008968)2.55432046
58Chorioretinal atrophy (HP:0000533)2.55346238
59Impaired vibration sensation in the lower limbs (HP:0002166)2.54933664
60Hyporeflexia of lower limbs (HP:0002600)2.52909871
61Bony spicule pigmentary retinopathy (HP:0007737)2.50040626
62Calf muscle hypertrophy (HP:0008981)2.49771154
63Abnormality of the costochondral junction (HP:0000919)2.48304476
64Atonic seizures (HP:0010819)2.48031366
65Urinary urgency (HP:0000012)2.43146342
66Prolonged QT interval (HP:0001657)2.40029486
67Short humerus (HP:0005792)2.39677561
68Cerebral aneurysm (HP:0004944)2.36762146
69Distal upper limb amyotrophy (HP:0007149)2.36072960
70Upper limb amyotrophy (HP:0009129)2.36072960
71Lower limb amyotrophy (HP:0007210)2.35240590
72Increased variability in muscle fiber diameter (HP:0003557)2.34960684
73Narrow nasal bridge (HP:0000446)2.34471236
74Generalized tonic-clonic seizures (HP:0002069)2.34334786
75Atrioventricular block (HP:0001678)2.33389468
76Difficulty climbing stairs (HP:0003551)2.31615051
77Flat occiput (HP:0005469)2.30410673
78Myotonia (HP:0002486)2.29883110
79Absence seizures (HP:0002121)2.28983632
80Rectal prolapse (HP:0002035)2.28407400
81Widely patent fontanelles and sutures (HP:0004492)2.27843825
82Absent thumb (HP:0009777)2.27393912
83Neoplasm of the heart (HP:0100544)2.27211214
84Abnormal social behavior (HP:0012433)2.26195287
85Impaired social interactions (HP:0000735)2.26195287
86Elfin facies (HP:0004428)2.26015798
87Enlarged epiphyses (HP:0010580)2.23427208
88Cerebral inclusion bodies (HP:0100314)2.21545173
89Dyschromatopsia (HP:0007641)2.21370823
90Macroorchidism (HP:0000053)2.19653878
91Progressive muscle weakness (HP:0003323)2.19033862
92Ankyloglossia (HP:0010296)2.18888836
93Annular pancreas (HP:0001734)2.18055286
94Abnormality of the calf musculature (HP:0001430)2.17627243
95Rapidly progressive (HP:0003678)2.16836839
96Dysdiadochokinesis (HP:0002075)2.16481639
97Congenital hip dislocation (HP:0001374)2.15491749
98Urinary bladder sphincter dysfunction (HP:0002839)2.15002567
99Deep palmar crease (HP:0006191)2.14666692
100Abnormality of the lower motor neuron (HP:0002366)2.14466869
101Dysmetria (HP:0001310)2.14302504
102Overriding aorta (HP:0002623)2.14239473
103Achilles tendon contracture (HP:0001771)2.13907056
104Pterygium (HP:0001059)2.13863128
105Amniotic constriction ring (HP:0009775)2.13196901
106Abnormality of placental membranes (HP:0011409)2.13196901
107Type 1 muscle fiber predominance (HP:0003803)2.12301858
108Poor eye contact (HP:0000817)2.11832072
109Increased number of teeth (HP:0011069)2.10688467
110Termporal pattern (HP:0011008)2.10217321
111Insidious onset (HP:0003587)2.10217321
112Myoglobinuria (HP:0002913)2.09260224
113Megalencephaly (HP:0001355)2.08957111
114Postural instability (HP:0002172)2.08750778
115Shallow orbits (HP:0000586)2.08433161
116Premature graying of hair (HP:0002216)2.08212057
117Easy fatigability (HP:0003388)2.08147718
118Distal lower limb amyotrophy (HP:0008944)2.08061761
119Absent radius (HP:0003974)2.07826961
120Spina bifida occulta (HP:0003298)2.06465327
121Spastic gait (HP:0002064)2.06002015
122Aplasia/hypoplasia of the humerus (HP:0006507)2.05420262
123Papilledema (HP:0001085)2.03481142
124Truncal ataxia (HP:0002078)2.02712763
125Facial diplegia (HP:0001349)2.02640025
126Impaired smooth pursuit (HP:0007772)2.02412367
127Basal cell carcinoma (HP:0002671)2.01944349
128Epileptic encephalopathy (HP:0200134)1.99834801
129Abnormality of skeletal muscle fiber size (HP:0012084)1.99777518
130Homocystinuria (HP:0002156)1.99540748
131Abnormality of homocysteine metabolism (HP:0010919)1.99540748
132Progressive cerebellar ataxia (HP:0002073)1.99320821
133Hypophosphatemic rickets (HP:0004912)1.96153196
134Dialeptic seizures (HP:0011146)1.95197248
135Hemiplegia (HP:0002301)1.95137544
136Scapular winging (HP:0003691)1.94961748
137Anxiety (HP:0000739)1.93572743
138Abnormal EKG (HP:0003115)1.91056635
139Joint hemorrhage (HP:0005261)1.89882664
140Absent forearm bone (HP:0003953)1.89117562
141Aplasia involving forearm bones (HP:0009822)1.89117562
142Renal duplication (HP:0000075)1.88481611
143Broad metatarsal (HP:0001783)1.87642448
144Broad-based gait (HP:0002136)1.87640737
145Flat cornea (HP:0007720)1.87553882
146Bronchomalacia (HP:0002780)1.82718270
147Malignant hyperthermia (HP:0002047)1.82308766
148Slender long bone (HP:0003100)1.80501547
149Wide cranial sutures (HP:0010537)1.79929070
150Syncope (HP:0001279)1.79845724
151Hypoventilation (HP:0002791)1.78518051
152Atrial fibrillation (HP:0005110)1.78474686
153Hypercortisolism (HP:0001578)1.78420876
154Muscle fiber splitting (HP:0003555)1.78188635
155Turricephaly (HP:0000262)1.77970945
156Pendular nystagmus (HP:0012043)1.77500017
157Increased connective tissue (HP:0009025)1.77211496
158Broad face (HP:0000283)1.76372825
159Hand muscle atrophy (HP:0009130)1.75940095
160External ophthalmoplegia (HP:0000544)1.75578315
161Primary atrial arrhythmia (HP:0001692)1.74926107
162Mask-like facies (HP:0000298)1.74561394
163Abnormality of the Achilles tendon (HP:0005109)1.74483778
164Limb-girdle muscle atrophy (HP:0003797)1.74330120
165Renovascular hypertension (HP:0100817)1.74083615
166Abnormality of the fingertips (HP:0001211)1.73543722
167Short thumb (HP:0009778)1.73088125
168Bowel diverticulosis (HP:0005222)1.72990842
169Prolonged partial thromboplastin time (HP:0003645)1.72403205
170Hypoalbuminemia (HP:0003073)1.71658470
171Abnormal albumin level (HP:0012116)1.71658470
172Subaortic stenosis (HP:0001682)1.71431837
173Abnormality of the left ventricular outflow tract (HP:0011103)1.71431837
174Abnormality of ocular smooth pursuit (HP:0000617)1.71352042
175EMG: myopathic abnormalities (HP:0003458)1.71242526
176Lower limb muscle weakness (HP:0007340)1.70549161
177Hypoplasia of the radius (HP:0002984)1.70232746
178Mildly elevated creatine phosphokinase (HP:0008180)1.70187614
179Intention tremor (HP:0002080)1.69718417
180Obsessive-compulsive behavior (HP:0000722)1.69674441
181Diminished movement (HP:0002374)1.68200969
182Neonatal onset (HP:0003623)1.68113872
183Hyperinsulinemic hypoglycemia (HP:0000825)1.65576124
184Abnormal atrioventricular conduction (HP:0005150)1.61397672
185Genu recurvatum (HP:0002816)1.59378231
186Hypoplasia of the pons (HP:0012110)1.58252026
187Cholelithiasis (HP:0001081)1.57287957
188Cheilitis (HP:0100825)1.55511239
189Germ cell neoplasia (HP:0100728)1.54170547
190Decreased circulating renin level (HP:0003351)1.53973892
191Progressive external ophthalmoplegia (HP:0000590)1.53164833
192Heart block (HP:0012722)1.52362497

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.83546291
2TRIB33.51600577
3EPHA43.34459356
4PRKD33.24062218
5MAP3K93.05635950
6SMG13.03561501
7NTRK33.03003437
8SIK12.98538581
9PAK62.36305580
10KSR22.30022731
11ERN12.21789787
12PKN22.17961047
13NTRK12.07792829
14TESK22.00422030
15TTN1.96218482
16IRAK31.93790387
17MAP3K41.90985538
18DMPK1.86905682
19GRK61.83960530
20ICK1.77607723
21CAMKK11.72317413
22DAPK21.70172633
23EEF2K1.69931778
24MINK11.68994376
25BLK1.68359572
26PRPF4B1.59147344
27PDGFRA1.54835014
28MST1R1.52192817
29MAP2K31.52115571
30MUSK1.52070522
31SIK21.51540641
32CAMK1G1.50033720
33TYRO31.48083759
34PHKG11.47691433
35PHKG21.47691433
36STK381.45670510
37IRAK21.44695016
38PNCK1.42578277
39UHMK11.40921368
40RIPK11.38980630
41ALK1.34745751
42TAOK11.30129527
43EPHA21.29786548
44KSR11.29024590
45CDK51.28794096
46MAP2K41.26156760
47WNK11.23358908
48RET1.22815828
49WNK41.21919488
50FGFR41.20654684
51CDK41.19761475
52PRKCH1.19200712
53MAP3K21.19103061
54MARK21.17632836
55SCYL21.15500221
56LMTK21.15211946
57MAPK111.14346716
58MAP3K71.13819299
59NEK21.13703134
60NTRK21.12555039
61BMX1.09298012
62DDR21.03061779
63FES1.02886899
64PAK31.01344014
65NME20.99992893
66ARAF0.95804664
67CAMK10.95753533
68MAP3K100.92151934
69FER0.89857308
70CDC42BPA0.89283038
71RPS6KB20.89184886
72MAPK120.86089714
73STK110.86018448
74TLK10.84762532
75LATS20.84659213
76MAP3K130.83881144
77PDPK10.82044252
78MAP3K10.81664169
79MAP2K60.80242371
80NEK10.80208419
81DYRK1B0.79833806
82PTK60.77430314
83ZAP700.77342518
84RPS6KC10.76902112
85RPS6KL10.76902112
86PTK2B0.76779702
87PAK40.76485530
88PDK10.75629686
89MAP3K110.74087630
90MARK10.73488014
91RIPK40.73487541
92CDK150.72494575
93MAPKAPK30.70557031
94CDK190.70325803
95BRAF0.68874142
96RPS6KA60.68505781
97PDGFRB0.68451164
98PTK20.68048781
99CDK180.67734757
100PRKD10.67670983
101STK160.67610130
102CDK140.66529021
103CDK11A0.65405506
104MAP2K20.64921589
105CAMK1D0.62389087
106HIPK20.61924324
107CAMKK20.61303870
108PRKD20.59972718
109MTOR0.59964017
110RAF10.59518687
111DAPK10.59307962
112CHEK20.59238320
113MAPK100.59110338
114ROCK20.58508395
115CDK120.56455291
116RPS6KA30.55752819
117SGK10.55702534
118PAK20.55361745
119MELK0.54757166
120MAP2K10.54665146
121CDK60.54586470
122TNK20.52806056
123PRKCG0.52265389
124MAPK80.51909653
125PDK40.50811318
126PDK30.50811318
127DAPK30.50026986
128CSNK1E0.49362560
129MET0.48993073
130STK390.48844908
131RPS6KA20.47988994
132CCNB10.47157411
133AURKA0.47119760
134CAMK2D0.46717315
135OBSCN0.45975609
136ILK0.44219353
137MAP3K80.43947236
138FYN0.42471168
139CAMK2B0.42277635
140CAMK2A0.42075815
141AKT20.39638493
142SGK30.39115876
143CAMK40.39009212
144ATR0.38745953
145CDK70.37618719
146RPS6KA10.37486202
147TAOK20.36556376
148CDK10.35162387
149CDK20.34094283
150PRKG20.33472967
151PRKAA10.33395303
152TBK10.33375577
153SGK2230.30669011

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041226.17953602
2Fructose and mannose metabolism_Homo sapiens_hsa000513.80811211
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.38551261
4Long-term potentiation_Homo sapiens_hsa047202.33556945
5Circadian entrainment_Homo sapiens_hsa047132.11086118
6Insulin secretion_Homo sapiens_hsa049112.10081813
7Olfactory transduction_Homo sapiens_hsa047402.07018065
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.06474971
9Synaptic vesicle cycle_Homo sapiens_hsa047212.02889214
10Amphetamine addiction_Homo sapiens_hsa050312.00442280
11Nicotine addiction_Homo sapiens_hsa050331.99875283
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99778125
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.97037666
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.89528865
15Gastric acid secretion_Homo sapiens_hsa049711.87530052
16Glutamatergic synapse_Homo sapiens_hsa047241.87126807
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.86540829
18Salivary secretion_Homo sapiens_hsa049701.82532817
19GABAergic synapse_Homo sapiens_hsa047271.82115715
20Dopaminergic synapse_Homo sapiens_hsa047281.82019915
21Other glycan degradation_Homo sapiens_hsa005111.81782944
22Morphine addiction_Homo sapiens_hsa050321.79530966
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.76848287
24Oxytocin signaling pathway_Homo sapiens_hsa049211.69233815
25Cholinergic synapse_Homo sapiens_hsa047251.68853505
26Type II diabetes mellitus_Homo sapiens_hsa049301.56417901
27Dilated cardiomyopathy_Homo sapiens_hsa054141.56366598
28Renin secretion_Homo sapiens_hsa049241.55865665
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.51966370
30GnRH signaling pathway_Homo sapiens_hsa049121.50937293
31Cocaine addiction_Homo sapiens_hsa050301.46913126
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.46004902
33Pancreatic secretion_Homo sapiens_hsa049721.42992843
34Glioma_Homo sapiens_hsa052141.41522280
35Estrogen signaling pathway_Homo sapiens_hsa049151.41341017
36Calcium signaling pathway_Homo sapiens_hsa040201.38426912
37Lysine degradation_Homo sapiens_hsa003101.37913396
38Long-term depression_Homo sapiens_hsa047301.37125188
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37122323
40Gap junction_Homo sapiens_hsa045401.37111074
41Notch signaling pathway_Homo sapiens_hsa043301.35123317
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.29521832
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28011493
44Sphingolipid metabolism_Homo sapiens_hsa006001.26736910
45Cardiac muscle contraction_Homo sapiens_hsa042601.26174991
46cAMP signaling pathway_Homo sapiens_hsa040241.20974325
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18114506
48Taste transduction_Homo sapiens_hsa047421.17803268
49Vitamin digestion and absorption_Homo sapiens_hsa049771.15299360
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14129427
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.13691248
52Melanogenesis_Homo sapiens_hsa049161.13283343
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12742569
54Biosynthesis of amino acids_Homo sapiens_hsa012301.10452722
55Vascular smooth muscle contraction_Homo sapiens_hsa042701.09859737
56VEGF signaling pathway_Homo sapiens_hsa043701.06716425
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06441116
58Phospholipase D signaling pathway_Homo sapiens_hsa040721.06420193
59Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04740567
60mTOR signaling pathway_Homo sapiens_hsa041501.04410781
61Glucagon signaling pathway_Homo sapiens_hsa049221.04087907
62ErbB signaling pathway_Homo sapiens_hsa040121.03914721
63Dorso-ventral axis formation_Homo sapiens_hsa043201.03774046
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03018595
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02850588
66Serotonergic synapse_Homo sapiens_hsa047261.01064697
67Axon guidance_Homo sapiens_hsa043600.99496214
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96608234
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.94876218
70Oocyte meiosis_Homo sapiens_hsa041140.93076285
71Thyroid hormone synthesis_Homo sapiens_hsa049180.93022717
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92770916
73Circadian rhythm_Homo sapiens_hsa047100.91958028
74Insulin signaling pathway_Homo sapiens_hsa049100.87286302
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86829735
76Fanconi anemia pathway_Homo sapiens_hsa034600.86746552
77Hippo signaling pathway_Homo sapiens_hsa043900.86019173
78Renal cell carcinoma_Homo sapiens_hsa052110.84195240
79Non-small cell lung cancer_Homo sapiens_hsa052230.83087322
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81458511
81Choline metabolism in cancer_Homo sapiens_hsa052310.81275740
82Nitrogen metabolism_Homo sapiens_hsa009100.80230818
83Arginine biosynthesis_Homo sapiens_hsa002200.80132696
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80070340
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79601693
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.76786702
87Base excision repair_Homo sapiens_hsa034100.76754092
88MAPK signaling pathway_Homo sapiens_hsa040100.75365197
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72859644
90Acute myeloid leukemia_Homo sapiens_hsa052210.72851945
91Rap1 signaling pathway_Homo sapiens_hsa040150.72532477
92Focal adhesion_Homo sapiens_hsa045100.69971686
93Endometrial cancer_Homo sapiens_hsa052130.68939953
94Chronic myeloid leukemia_Homo sapiens_hsa052200.68610813
95Endocytosis_Homo sapiens_hsa041440.67726034
96Tight junction_Homo sapiens_hsa045300.67195458
97Proteoglycans in cancer_Homo sapiens_hsa052050.65059329
98AMPK signaling pathway_Homo sapiens_hsa041520.63664784
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63510356
100Lysosome_Homo sapiens_hsa041420.61959781
101Pyruvate metabolism_Homo sapiens_hsa006200.61736493
102Insulin resistance_Homo sapiens_hsa049310.61516262
103Basal cell carcinoma_Homo sapiens_hsa052170.60251963
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59632285
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58597687
106Galactose metabolism_Homo sapiens_hsa000520.58492137
107Platelet activation_Homo sapiens_hsa046110.58078395
108Wnt signaling pathway_Homo sapiens_hsa043100.57973548
109Pentose phosphate pathway_Homo sapiens_hsa000300.57857610
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57609763
111Alcoholism_Homo sapiens_hsa050340.57271479
112Cell cycle_Homo sapiens_hsa041100.57070839
113Bladder cancer_Homo sapiens_hsa052190.56898788
114Phenylalanine metabolism_Homo sapiens_hsa003600.56445628
115Thyroid cancer_Homo sapiens_hsa052160.56333240
116Vibrio cholerae infection_Homo sapiens_hsa051100.55969299
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.55137163
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54429808
119Pancreatic cancer_Homo sapiens_hsa052120.54232778
120Hedgehog signaling pathway_Homo sapiens_hsa043400.52913906
121Inositol phosphate metabolism_Homo sapiens_hsa005620.51320192
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51299308
123Protein digestion and absorption_Homo sapiens_hsa049740.51242286
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.49348452
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49339814
126Ras signaling pathway_Homo sapiens_hsa040140.47496148
127DNA replication_Homo sapiens_hsa030300.46564060
128mRNA surveillance pathway_Homo sapiens_hsa030150.46533219
129Prolactin signaling pathway_Homo sapiens_hsa049170.45152561
130HIF-1 signaling pathway_Homo sapiens_hsa040660.44647829
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44020489
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43381696
1332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43324262
134Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42620217
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.42092941
136Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41489519
137Prion diseases_Homo sapiens_hsa050200.38458392
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36602030
139Hepatitis C_Homo sapiens_hsa051600.36294024
140Fat digestion and absorption_Homo sapiens_hsa049750.35634282
141Colorectal cancer_Homo sapiens_hsa052100.35220767
142Vitamin B6 metabolism_Homo sapiens_hsa007500.34865420
143MicroRNAs in cancer_Homo sapiens_hsa052060.33476637
144Bile secretion_Homo sapiens_hsa049760.33117798
145Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32823379
146Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.28890023
147B cell receptor signaling pathway_Homo sapiens_hsa046620.28277565
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26897338
149Small cell lung cancer_Homo sapiens_hsa052220.26423662
150HTLV-I infection_Homo sapiens_hsa051660.26056417

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