RAC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.10852711
2Golgi transport vesicle coating (GO:0048200)5.10852711
3protein retention in ER lumen (GO:0006621)4.85123196
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.74358945
5desmosome organization (GO:0002934)3.95757144
6retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.79664906
7regulation of early endosome to late endosome transport (GO:2000641)3.78928834
8protein localization to endosome (GO:0036010)3.78776216
9protein maturation by protein folding (GO:0022417)3.75346824
10stress fiber assembly (GO:0043149)3.52033019
11Arp2/3 complex-mediated actin nucleation (GO:0034314)3.29501847
12positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.20023063
13cortical actin cytoskeleton organization (GO:0030866)3.19279189
14renal filtration (GO:0097205)3.14131911
15cell adhesion mediated by integrin (GO:0033627)3.13087935
16planar cell polarity pathway involved in neural tube closure (GO:0090179)3.12112377
17regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.07519897
18barbed-end actin filament capping (GO:0051016)3.00389117
19glomerular filtration (GO:0003094)2.98612073
20hippo signaling (GO:0035329)2.96174197
21positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.95845486
22regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.95845486
23regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.95440108
24* positive regulation of lamellipodium assembly (GO:0010592)2.92100898
25glucocorticoid receptor signaling pathway (GO:0042921)2.90295083
26dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.89435603
27sodium ion export (GO:0071436)2.88465846
28regulation of mammary gland epithelial cell proliferation (GO:0033599)2.86461144
29cellular copper ion homeostasis (GO:0006878)2.84840976
30mesodermal cell differentiation (GO:0048333)2.83751941
31regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.80310136
32activation of Rac GTPase activity (GO:0032863)2.75041327
33negative regulation of fatty acid transport (GO:2000192)2.74389623
34regulation of mitotic spindle organization (GO:0060236)2.74249190
35cortical cytoskeleton organization (GO:0030865)2.73546843
36hemidesmosome assembly (GO:0031581)2.73125653
37focal adhesion assembly (GO:0048041)2.70701139
38cell-substrate adherens junction assembly (GO:0007045)2.70701139
39negative regulation of catenin import into nucleus (GO:0035414)2.70337214
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.67831603
41cytoskeletal anchoring at plasma membrane (GO:0007016)2.67756072
42establishment of endothelial barrier (GO:0061028)2.66962279
43basement membrane organization (GO:0071711)2.66478643
44glutamate secretion (GO:0014047)2.65717564
45positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.64165458
46adhesion of symbiont to host cell (GO:0044650)2.63664428
47virion attachment to host cell (GO:0019062)2.63664428
48nucleobase-containing small molecule interconversion (GO:0015949)2.62556116
49lens fiber cell development (GO:0070307)2.62512479
50* localization within membrane (GO:0051668)2.62131259
51regulation of water loss via skin (GO:0033561)2.61022142
52hypotonic response (GO:0006971)2.60705403
53morphogenesis of an endothelium (GO:0003159)2.60543002
54endothelial tube morphogenesis (GO:0061154)2.60543002
55protein targeting to plasma membrane (GO:0072661)2.60268826
56cell-substrate junction assembly (GO:0007044)2.59551599
57vesicle coating (GO:0006901)2.59430688
58regulation of glucose import in response to insulin stimulus (GO:2001273)2.59305601
59adhesion of symbiont to host (GO:0044406)2.58613908
60apoptotic cell clearance (GO:0043277)2.58067219
61neuron projection extension involved in neuron projection guidance (GO:1902284)2.57823813
62axon extension involved in axon guidance (GO:0048846)2.57823813
63regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.57010556
64establishment of protein localization to plasma membrane (GO:0090002)2.56930237
65modulation by virus of host morphology or physiology (GO:0019048)2.56623856
66regulation of protein dephosphorylation (GO:0035304)2.56525805
67positive regulation of Cdc42 GTPase activity (GO:0043089)2.56142494
68blood vessel maturation (GO:0001955)2.55872201
69synaptic vesicle docking involved in exocytosis (GO:0016081)2.55636469
70actin filament bundle organization (GO:0061572)2.55396164
71actin filament bundle assembly (GO:0051017)2.55396164
72* semaphorin-plexin signaling pathway (GO:0071526)2.52673847
73synaptic vesicle maturation (GO:0016188)2.52359167
74cell-cell junction maintenance (GO:0045217)2.52162085
75proline biosynthetic process (GO:0006561)2.50586518
76branching involved in mammary gland duct morphogenesis (GO:0060444)2.50266282
77glucose 6-phosphate metabolic process (GO:0051156)2.49186580
78chondrocyte proliferation (GO:0035988)2.48460820
79mating behavior (GO:0007617)2.47249896
80* positive regulation of lamellipodium organization (GO:1902745)2.46818593
81corticosteroid receptor signaling pathway (GO:0031958)2.46256887
82positive regulation of tolerance induction (GO:0002645)2.44216370
83dermatan sulfate biosynthetic process (GO:0030208)2.42852806
84regulation of glomerular filtration (GO:0003093)2.41683881
85actin nucleation (GO:0045010)2.40765951
86regulation of clathrin-mediated endocytosis (GO:2000369)2.40085342
87negative regulation of protein localization to plasma membrane (GO:1903077)2.39893612
88layer formation in cerebral cortex (GO:0021819)2.39550374
89Rap protein signal transduction (GO:0032486)2.37768382
90activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.37662296
91clathrin coat assembly (GO:0048268)2.37167631
92polarized epithelial cell differentiation (GO:0030859)2.37006461
93muscle cell migration (GO:0014812)2.36708753
94regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.36605717
95* substrate adhesion-dependent cell spreading (GO:0034446)2.36519470
96growth hormone receptor signaling pathway (GO:0060396)2.36489968
97negative regulation of ERBB signaling pathway (GO:1901185)2.36436095
98cellular protein complex localization (GO:0034629)2.36175728
99negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059)2.34902700
100regulation of protein heterodimerization activity (GO:0043497)2.33680793
101receptor recycling (GO:0001881)2.33374554
102nuclear envelope reassembly (GO:0031468)2.32810024
103mitotic nuclear envelope reassembly (GO:0007084)2.32810024
104prostanoid biosynthetic process (GO:0046457)2.31043164
105prostaglandin biosynthetic process (GO:0001516)2.31043164
106regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.30707644
107negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.30649074
108lung lobe morphogenesis (GO:0060463)2.30139061
109positive regulation of nuclease activity (GO:0032075)2.29984413
110positive regulation of macrophage cytokine production (GO:0060907)2.29939925
111actin filament depolymerization (GO:0030042)2.29832285
112endocytic recycling (GO:0032456)2.29600102
113embryo implantation (GO:0007566)2.29477906
114positive regulation of pseudopodium assembly (GO:0031274)2.29096338
115pentose-phosphate shunt (GO:0006098)2.28524985
116protein complex localization (GO:0031503)2.28213803
117positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.28187464
118positive regulation of protein localization to plasma membrane (GO:1903078)2.28140849
119DNA unwinding involved in DNA replication (GO:0006268)2.28011322
120regulation of macrophage cytokine production (GO:0010935)2.27782014
121cyclooxygenase pathway (GO:0019371)2.27406780
122response to laminar fluid shear stress (GO:0034616)2.27010274
123surfactant homeostasis (GO:0043129)2.25904531
124maternal placenta development (GO:0001893)2.25778861
125endothelial cell morphogenesis (GO:0001886)2.24682967
126nerve growth factor signaling pathway (GO:0038180)2.24653540
127adenosine receptor signaling pathway (GO:0001973)2.23767926
128membrane raft organization (GO:0031579)2.23648135
129substrate-dependent cell migration (GO:0006929)2.23158722
130dermatan sulfate metabolic process (GO:0030205)2.22321695
131positive regulation of actin filament depolymerization (GO:0030836)2.21970359
132patterning of blood vessels (GO:0001569)2.21744099
133endodermal cell differentiation (GO:0035987)2.20699565
134negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.20327293
135regulation of integrin-mediated signaling pathway (GO:2001044)2.20320828
136positive regulation of epithelial to mesenchymal transition (GO:0010718)2.19222934
137regulation of protein localization to plasma membrane (GO:1903076)2.18879138
138positive regulation of receptor recycling (GO:0001921)2.18217384
139regulation of ARF GTPase activity (GO:0032312)2.18038556
140peptidyl-proline hydroxylation (GO:0019511)2.18005932
141negative regulation of vascular permeability (GO:0043116)2.17559983
142integrin-mediated signaling pathway (GO:0007229)2.15677528
143cellular response to growth hormone stimulus (GO:0071378)2.12335254
144adherens junction assembly (GO:0034333)2.11232021
145lymphangiogenesis (GO:0001946)2.10629444
146regulation of tight junction assembly (GO:2000810)2.10090788
147regulation of tolerance induction (GO:0002643)2.09327618
148germ cell migration (GO:0008354)2.08944572
149positive regulation of glycoprotein metabolic process (GO:1903020)2.06894759
150radial glial cell differentiation (GO:0060019)2.06786751
151skin morphogenesis (GO:0043589)2.06660783
152peptidyl-tyrosine autophosphorylation (GO:0038083)2.06269275
153endocardial cushion development (GO:0003197)2.05856031
154chondrocyte development (GO:0002063)2.05384503
155regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.05209340
156epithelial cell-cell adhesion (GO:0090136)2.04764495
157myelin maintenance (GO:0043217)2.03768061
158negative regulation of cardiac muscle tissue growth (GO:0055022)2.03381775
159negative regulation of heart growth (GO:0061117)2.03381775
160SMAD protein complex assembly (GO:0007183)2.02981950
161regulation of SMAD protein import into nucleus (GO:0060390)2.02836319
162* Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.02724597
163vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.02580690
164vascular endothelial growth factor signaling pathway (GO:0038084)2.02058549
165membrane budding (GO:0006900)2.00942930
166cellular potassium ion homeostasis (GO:0030007)2.00159239
167* Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)1.99909222
168* immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00021.99909222
169* Fc-gamma receptor signaling pathway (GO:0038094)1.99909222
170negative regulation of smooth muscle cell migration (GO:0014912)1.99530678
171positive regulation of blood vessel endothelial cell migration (GO:0043536)1.98761136
172epithelial cell differentiation involved in prostate gland development (GO:0060742)1.98760883
173positive regulation of histone deacetylation (GO:0031065)1.98401145
174receptor catabolic process (GO:0032801)1.98231444
175regulation of T cell tolerance induction (GO:0002664)1.98168156
176renal system development (GO:0072001)1.97972019
177platelet aggregation (GO:0070527)1.97721291
178branching involved in salivary gland morphogenesis (GO:0060445)1.96693169

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.11071798
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.77789244
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.51093970
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.46683243
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.14689788
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.67384305
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.34824146
8WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.33920613
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.31771216
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.27807449
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.27192652
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.22281001
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.20951783
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.16211022
15KDM2B_26808549_Chip-Seq_DND41_Human2.12298355
16CLOCK_20551151_ChIP-Seq_293T_Human2.09383593
17EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.93566867
18TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.92751610
19VDR_21846776_ChIP-Seq_THP-1_Human1.89840939
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86714283
21SRY_22984422_ChIP-ChIP_TESTIS_Rat1.82392550
22VDR_24763502_ChIP-Seq_THP-1_Human1.78242987
23* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.77239267
24* TCF7_22412390_ChIP-Seq_EML_Mouse1.76264479
25* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.75059587
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75036487
27* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.73812249
28* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.70689625
29KDM2B_26808549_Chip-Seq_JURKAT_Human1.68733836
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.68472737
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.68217284
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.67512307
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66531818
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65220448
35MYC_22102868_ChIP-Seq_BL_Human1.64067958
36AR_21909140_ChIP-Seq_LNCAP_Human1.63744260
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63315915
38KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.61594684
39* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.60307796
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59307544
41RUNX_20019798_ChIP-Seq_JUKART_Human1.58416372
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.58270588
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57158320
44* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.57101634
45SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.56950712
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.56213504
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52404770
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.52321297
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.51883636
50KDM2B_26808549_Chip-Seq_K562_Human1.51011323
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.49627755
52ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.49567695
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.48129199
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44852129
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.43216935
56SPI1_23127762_ChIP-Seq_K562_Human1.43131806
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.42228755
58RACK7_27058665_Chip-Seq_MCF-7_Human1.41781761
59MAF_26560356_Chip-Seq_TH1_Human1.41465627
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.40336613
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40159939
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40133114
63LXR_22292898_ChIP-Seq_THP-1_Human1.39599514
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38765287
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38588776
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38504955
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36875641
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.36477245
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35496479
70* IRF8_27001747_Chip-Seq_BMDM_Mouse1.35136965
71* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34657890
72* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34164966
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33875461
74SCL_19346495_ChIP-Seq_HPC-7_Human1.32895027
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32760656
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32172660
77VDR_24787735_ChIP-Seq_THP-1_Human1.31821761
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31645718
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.31286055
80HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29953292
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27517486
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27438080
83SOX2_20726797_ChIP-Seq_SW620_Human1.26424898
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26329891
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26010661
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23969535
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23953859
88STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22673811
89BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22352394
90FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.21845990
91OCT4_18692474_ChIP-Seq_MEFs_Mouse1.21677068
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21501920
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21355961
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20831741
95SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19201662
96MYC_18555785_ChIP-Seq_MESCs_Mouse1.18947221
97* CJUN_26792858_Chip-Seq_BT549_Human1.18312553
98ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.18200961
99UBF1/2_26484160_Chip-Seq_HMECs_Human1.17851076
100BRD4_25478319_ChIP-Seq_HGPS_Human1.15135539
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14644468
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14172919
103DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13816182
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13440614
105MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13298179
106CDX2_20551321_ChIP-Seq_CACO-2_Human1.13238353
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13188317
108ZNF263_19887448_ChIP-Seq_K562_Human1.13062465
109NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13003073
110CREB1_26743006_Chip-Seq_LNCaP_Human1.12316402
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12302222
112SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12204776
113SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12204776
114SMC1_22415368_ChIP-Seq_MEFs_Mouse1.11875340
115RXR_22108803_ChIP-Seq_LS180_Human1.10786979
116ATF3_27146783_Chip-Seq_COLON_Human1.10397466
117PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09762071
118TET1_21490601_ChIP-Seq_MESCs_Mouse1.08606878
119SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07002199
120* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06045605
121* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05980908
122UTX_26944678_Chip-Seq_JUKART_Human1.05273012
123TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.04769951
124SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04446387
125NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03520606
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03520606
127* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03447792
128SMC4_20622854_ChIP-Seq_HELA_Human1.03287196
129SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.03216160
130Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03111216
131WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02373600
132MYB_26560356_Chip-Seq_TH2_Human1.01926643
133SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01724668
134CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00959860
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00778039
136EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00705789
137RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00705789
138TP53_16413492_ChIP-PET_HCT116_Human1.00662510
139EP300_21415370_ChIP-Seq_HL-1_Mouse1.00525680
140TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00328571
141SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99856773
142EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99676094
143AR_21572438_ChIP-Seq_LNCaP_Human0.99617877
144PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99482107
145CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99242293
146RUNX1_27514584_Chip-Seq_MCF-7_Human0.99055549
147SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98973528
148CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98398915
149SA1_27219007_Chip-Seq_ERYTHROID_Human0.97546479
150TP53_22127205_ChIP-Seq_IMR90_Human0.96720945
151* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96574060
152STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94321574
153* P68_20966046_ChIP-Seq_HELA_Human0.93821927
154MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93323724
155HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92401762

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.52561687
2MP0003300_gastrointestinal_ulcer3.10806995
3MP0002796_impaired_skin_barrier3.03922002
4MP0008438_abnormal_cutaneous_collagen2.87886202
5MP0003303_peritoneal_inflammation2.65977343
6MP0005623_abnormal_meninges_morphology2.44648858
7MP0005257_abnormal_intraocular_pressure2.42866568
8MP0009780_abnormal_chondrocyte_physiolo2.40346552
9MP0004272_abnormal_basement_membrane2.40033756
10MP0010234_abnormal_vibrissa_follicle2.35274930
11MP0005409_darkened_coat_color2.34428400
12MP0006054_spinal_hemorrhage2.32126389
13MP0000537_abnormal_urethra_morphology2.31349588
14MP0009379_abnormal_foot_pigmentation2.27993600
15MP0010368_abnormal_lymphatic_system2.24647754
16MP0003123_paternal_imprinting2.14233633
17MP0010352_gastrointestinal_tract_polyps2.13744074
18MP0003566_abnormal_cell_adhesion2.08815185
19MP0001958_emphysema2.06948026
20MP0003279_aneurysm2.05643180
21MP0005275_abnormal_skin_tensile2.02799906
22MP0005076_abnormal_cell_differentiation2.02002638
23MP0000733_abnormal_muscle_development2.01377933
24* MP0005501_abnormal_skin_physiology1.97909281
25MP0003329_amyloid_beta_deposits1.92208265
26MP0001879_abnormal_lymphatic_vessel1.91649116
27MP0005167_abnormal_blood-brain_barrier1.85371849
28MP0000579_abnormal_nail_morphology1.80753143
29MP0003091_abnormal_cell_migration1.79071577
30MP0009053_abnormal_anal_canal1.74864531
31MP0009384_cardiac_valve_regurgitation1.74715131
32MP0000678_abnormal_parathyroid_gland1.69907388
33MP0005503_abnormal_tendon_morphology1.68481688
34MP0008260_abnormal_autophagy1.66907954
35MP0000762_abnormal_tongue_morphology1.63415232
36MP0000566_synostosis1.51142221
37MP0000343_altered_response_to1.48036842
38MP0002060_abnormal_skin_morphology1.44437247
39MP0009278_abnormal_bone_marrow1.43120195
40MP0005058_abnormal_lysosome_morphology1.41736713
41MP0003191_abnormal_cellular_cholesterol1.40933236
42MP0003941_abnormal_skin_development1.40636641
43MP0010678_abnormal_skin_adnexa1.40150907
44MP0005023_abnormal_wound_healing1.38276327
45MP0004782_abnormal_surfactant_physiolog1.34203794
46MP0003075_altered_response_to1.31136090
47MP0004264_abnormal_extraembryonic_tissu1.30138062
48MP0003828_pulmonary_edema1.27955974
49MP0004270_analgesia1.27424391
50MP0001533_abnormal_skeleton_physiology1.27250487
51MP0000920_abnormal_myelination1.27140392
52MP0000534_abnormal_ureter_morphology1.26817384
53MP0004858_abnormal_nervous_system1.25402824
54MP0009250_abnormal_appendicular_skeleto1.23872186
55MP0001299_abnormal_eye_distance/1.22811933
56MP0002166_altered_tumor_susceptibility1.21843854
57MP0000465_gastrointestinal_hemorrhage1.21708814
58MP0004808_abnormal_hematopoietic_stem1.21668461
59MP0003950_abnormal_plasma_membrane1.18941374
60MP0010030_abnormal_orbit_morphology1.18385714
61MP0003436_decreased_susceptibility_to1.18367855
62MP0002098_abnormal_vibrissa_morphology1.17790427
63MP0003634_abnormal_glial_cell1.17727448
64MP0005248_abnormal_Harderian_gland1.16865277
65MP0000767_abnormal_smooth_muscle1.15889831
66MP0000467_abnormal_esophagus_morphology1.14515959
67MP0002249_abnormal_larynx_morphology1.14509326
68MP0002282_abnormal_trachea_morphology1.14118050
69MP0005165_increased_susceptibility_to1.12461042
70* MP0001216_abnormal_epidermal_layer1.10848717
71MP0009840_abnormal_foam_cell1.10439486
72MP0002998_abnormal_bone_remodeling1.09766044
73MP0001851_eye_inflammation1.08997213
74MP0002089_abnormal_postnatal_growth/wei1.08206000
75MP0001881_abnormal_mammary_gland1.08086041
76MP0000627_abnormal_mammary_gland1.07650435
77MP0003448_altered_tumor_morphology1.07125558
78MP0003385_abnormal_body_wall1.06112318
79MP0005451_abnormal_body_composition1.06011326
80MP0005508_abnormal_skeleton_morphology1.05645247
81MP0003122_maternal_imprinting1.05563378
82MP0001849_ear_inflammation1.03202158
83MP0005367_renal/urinary_system_phenotyp1.03117053
84MP0000516_abnormal_urinary_system1.03117053
85MP0002925_abnormal_cardiovascular_devel1.02477986
86MP0008932_abnormal_embryonic_tissue1.00695404
87MP0002896_abnormal_bone_mineralization1.00179770
88MP0004947_skin_inflammation1.00096219
89MP0003942_abnormal_urinary_system0.99648185
90MP0004185_abnormal_adipocyte_glucose0.99002116
91MP0005166_decreased_susceptibility_to0.98296672
92MP0000681_abnormal_thyroid_gland0.98058782
93MP0001346_abnormal_lacrimal_gland0.97609091
94MP0005390_skeleton_phenotype0.96475279
95MP0002006_tumorigenesis0.95558674
96MP0005666_abnormal_adipose_tissue0.95193792
97MP0000383_abnormal_hair_follicle0.95137839
98MP0004859_abnormal_synaptic_plasticity0.93357630
99MP0003172_abnormal_lysosome_physiology0.93172915
100MP0000751_myopathy0.92906506
101MP0004510_myositis0.91790356
102MP0002933_joint_inflammation0.91495787
103MP0005397_hematopoietic_system_phenotyp0.91486217
104MP0001545_abnormal_hematopoietic_system0.91486217
105* MP0010771_integument_phenotype0.90759361
106MP0001915_intracranial_hemorrhage0.90739587
107MP0002128_abnormal_blood_circulation0.90670554
108MP0002113_abnormal_skeleton_development0.89723165
109MP0001614_abnormal_blood_vessel0.88794003
110MP0002877_abnormal_melanocyte_morpholog0.88264124
111MP0000569_abnormal_digit_pigmentation0.88074717
112MP0001730_embryonic_growth_arrest0.86933911
113MP0000747_muscle_weakness0.86275329
114MP0002932_abnormal_joint_morphology0.85990354
115MP0000003_abnormal_adipose_tissue0.84705637
116MP0003115_abnormal_respiratory_system0.84493887
117MP0000462_abnormal_digestive_system0.83798428
118MP0003879_abnormal_hair_cell0.83165320
119MP0003690_abnormal_glial_cell0.83078611
120MP0000249_abnormal_blood_vessel0.82266421
121MP0000428_abnormal_craniofacial_morphol0.82159858
122MP0005464_abnormal_platelet_physiology0.81823862
123MP0002419_abnormal_innate_immunity0.79426916
124MP0001542_abnormal_bone_strength0.78888098
125MP0010155_abnormal_intestine_physiology0.78851683
126* MP0003453_abnormal_keratinocyte_physiol0.77740401
127MP0003315_abnormal_perineum_morphology0.77264509
128MP0005621_abnormal_cell_physiology0.76958652
129MP0004883_abnormal_blood_vessel0.76601192
130MP0005164_abnormal_response_to0.75247291
131MP0001853_heart_inflammation0.74606364
132MP0000163_abnormal_cartilage_morphology0.73946956
133MP0000858_altered_metastatic_potential0.73851395
134MP0000685_abnormal_immune_system0.73785519
135MP0001727_abnormal_embryo_implantation0.73453792
136MP0005388_respiratory_system_phenotype0.72109000
137MP0002133_abnormal_respiratory_system0.72109000
138MP0004233_abnormal_muscle_weight0.72014926
139MP0003183_abnormal_peptide_metabolism0.71988727
140* MP0000377_abnormal_hair_follicle0.71757207
141MP0008961_abnormal_basal_metabolism0.71735136
142MP0001348_abnormal_lacrimal_gland0.71307194
143MP0000350_abnormal_cell_proliferation0.71274603
144MP0003567_abnormal_fetal_cardiomyocyte0.71180152
145MP0000750_abnormal_muscle_regeneration0.71039138
146MP0002115_abnormal_skeleton_extremities0.70990267
147MP0002396_abnormal_hematopoietic_system0.70226402
148MP0005375_adipose_tissue_phenotype0.70185470
149MP0003045_fibrosis0.69629809
150MP0002405_respiratory_system_inflammati0.68209923
151MP0005197_abnormal_uvea_morphology0.68198711
152MP0004957_abnormal_blastocyst_morpholog0.67504148
153MP0009672_abnormal_birth_weight0.66083072
154MP0000604_amyloidosis0.65972715
155MP0005193_abnormal_anterior_eye0.63773914

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.92215888
2Shallow orbits (HP:0000586)3.71135202
3Cerebral aneurysm (HP:0004944)3.27803206
4Aortic aneurysm (HP:0004942)3.19646518
5Insomnia (HP:0100785)3.19481587
6Hyperparathyroidism (HP:0000843)3.10481108
7Hematochezia (HP:0002573)3.10369539
8Arterial tortuosity (HP:0005116)3.04589966
9Distal lower limb muscle weakness (HP:0009053)3.03842138
10Upper limb amyotrophy (HP:0009129)3.01986721
11Distal upper limb amyotrophy (HP:0007149)3.01986721
12Vascular tortuosity (HP:0004948)2.92284005
13Cerebral inclusion bodies (HP:0100314)2.91233757
14Broad metatarsal (HP:0001783)2.78513977
15Abnormality of the Achilles tendon (HP:0005109)2.78315833
16Aortic dissection (HP:0002647)2.76491967
17Distal lower limb amyotrophy (HP:0008944)2.73551059
18Increased cerebral lipofuscin (HP:0011813)2.71042090
19Papilledema (HP:0001085)2.67639053
20Hand muscle atrophy (HP:0009130)2.61852366
21Premature rupture of membranes (HP:0001788)2.60636661
22Short 4th metacarpal (HP:0010044)2.58219529
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.58219529
24Deviation of the hallux (HP:0010051)2.51964161
25Hallux valgus (HP:0001822)2.44550424
26Nuclear cataract (HP:0100018)2.43652685
27Lower limb amyotrophy (HP:0007210)2.42523375
28Dilatation of the ascending aorta (HP:0005111)2.42513154
29Megalencephaly (HP:0001355)2.40058236
30Short nail (HP:0001799)2.39635998
31Supranuclear gaze palsy (HP:0000605)2.36680550
32Mitral valve prolapse (HP:0001634)2.36021372
33Macroorchidism (HP:0000053)2.35528100
34Ankyloglossia (HP:0010296)2.35283675
35Increased neuronal autofluorescent lipopigment (HP:0002074)2.34882088
36Dysostosis multiplex (HP:0000943)2.30213277
37Hypercalcemia (HP:0003072)2.28498872
38Increased density of long bones (HP:0006392)2.24282306
39Spinal rigidity (HP:0003306)2.23873432
40Genu recurvatum (HP:0002816)2.21861058
41Buphthalmos (HP:0000557)2.21858568
42Coronal craniosynostosis (HP:0004440)2.20282029
43Elfin facies (HP:0004428)2.20259771
44Disinhibition (HP:0000734)2.18074927
45Abnormality of the distal phalanges of the toes (HP:0010182)2.16544867
46Atrophic scars (HP:0001075)2.14396116
47Termporal pattern (HP:0011008)2.13161043
48Insidious onset (HP:0003587)2.13161043
49Abnormality of liposaccharide metabolism (HP:0010968)2.13137273
50Abnormality of glycosphingolipid metabolism (HP:0004343)2.13137273
51Abnormality of glycolipid metabolism (HP:0010969)2.13137273
52Diminished motivation (HP:0000745)2.11728024
53Bladder diverticulum (HP:0000015)2.11281991
54Ankle contracture (HP:0006466)2.08876401
55Overgrowth (HP:0001548)2.06711390
56Back pain (HP:0003418)2.06427183
57Abnormality of the 4th metacarpal (HP:0010012)2.05568304
58Trismus (HP:0000211)2.05516422
59Peritonitis (HP:0002586)2.05173877
60Striae distensae (HP:0001065)2.04405864
61Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.04348763
62Right ventricular cardiomyopathy (HP:0011663)2.03838969
63Subacute progressive viral hepatitis (HP:0006572)2.03574069
64Spondylolisthesis (HP:0003302)2.02521804
65Turricephaly (HP:0000262)2.00944929
66Abnormality of oral frenula (HP:0000190)2.00524737
67Spinal cord compression (HP:0002176)2.00237858
68Fragile skin (HP:0001030)1.98225117
69Enlarged penis (HP:0000040)1.97036009
70Hyperacusis (HP:0010780)1.96619815
71Apathy (HP:0000741)1.96147874
72Rectal prolapse (HP:0002035)1.96008240
73Asymmetry of the thorax (HP:0001555)1.93098371
74Mitral regurgitation (HP:0001653)1.92128518
75Disproportionate tall stature (HP:0001519)1.91289640
76Osteolytic defects of the hand bones (HP:0009699)1.91160691
77Osteolytic defects of the phalanges of the hand (HP:0009771)1.91160691
78Centrally nucleated skeletal muscle fibers (HP:0003687)1.90567033
79Interstitial pulmonary disease (HP:0006530)1.90342928
80Polycythemia (HP:0001901)1.89880856
81Spontaneous hematomas (HP:0007420)1.89427279
82Annular pancreas (HP:0001734)1.88417116
83Hyperextensible skin (HP:0000974)1.87778463
84Flat acetabular roof (HP:0003180)1.87676485
85Thin bony cortex (HP:0002753)1.87438116
86Achilles tendon contracture (HP:0001771)1.86890108
87Abnormality of the 2nd finger (HP:0004100)1.86717614
88Exostoses (HP:0100777)1.86369131
89Hypercortisolism (HP:0001578)1.85934299
90Ulnar bowing (HP:0003031)1.85326681
91Action tremor (HP:0002345)1.84456442
92Eczematoid dermatitis (HP:0000976)1.83622830
93Neuronal loss in central nervous system (HP:0002529)1.83604257
94Aplasia of the phalanges of the hand (HP:0009802)1.83370958
95Aplasia involving bones of the extremities (HP:0009825)1.83370958
96Aplasia involving bones of the upper limbs (HP:0009823)1.83370958
97Aneurysm (HP:0002617)1.82170649
98Multiple lipomas (HP:0001012)1.80770408
99Increased connective tissue (HP:0009025)1.79946718
100Cervical subluxation (HP:0003308)1.79073383
101Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.78783119
102Mucopolysacchariduria (HP:0008155)1.78579371
103Urinary glycosaminoglycan excretion (HP:0003541)1.78579371
104Bone pain (HP:0002653)1.78009101
105Overriding aorta (HP:0002623)1.77792533
106Lymphangioma (HP:0100764)1.77466540
107Patellar dislocation (HP:0002999)1.76378670
108Obstructive sleep apnea (HP:0002870)1.74408452
109Mildly elevated creatine phosphokinase (HP:0008180)1.73565892
110Trigonocephaly (HP:0000243)1.72316489
111Neurofibrillary tangles (HP:0002185)1.71985278
112Distal sensory impairment (HP:0002936)1.71617886
113Soft skin (HP:0000977)1.71403470
114Blue sclerae (HP:0000592)1.70943061
115Cellulitis (HP:0100658)1.70742583
116Scapular winging (HP:0003691)1.69976675
117Foot dorsiflexor weakness (HP:0009027)1.69708326
118Mutism (HP:0002300)1.69652039
119Camptodactyly of toe (HP:0001836)1.69268338
120Long palpebral fissure (HP:0000637)1.68488236
121Bronchomalacia (HP:0002780)1.67241521
122Hyperthyroidism (HP:0000836)1.66939827
123Hammertoe (HP:0001765)1.65951622
124Abnormality of nail color (HP:0100643)1.64637154
125Bicuspid aortic valve (HP:0001647)1.64607397
126Pili torti (HP:0003777)1.64183415
127Arnold-Chiari malformation (HP:0002308)1.63864569
128Abnormality of carpal bone ossification (HP:0006257)1.63787661
129J-shaped sella turcica (HP:0002680)1.63678196
130Selective tooth agenesis (HP:0001592)1.63058952
131Narrow palate (HP:0000189)1.63043354
132Growth hormone excess (HP:0000845)1.62248042
133Abnormality of the gastric mucosa (HP:0004295)1.62184773
134Osteopenia (HP:0000938)1.61520606
135Abnormality of the acetabulum (HP:0003170)1.61391044
136Axonal loss (HP:0003447)1.61302809
137Fatigue (HP:0012378)1.60892881
138Myokymia (HP:0002411)1.60761416
139Abnormality of the lumbar spine (HP:0100712)1.60119396
140Abnormality of the peritoneum (HP:0002585)1.60028472
141Congenital glaucoma (HP:0001087)1.59775282
142Natal tooth (HP:0000695)1.59629455
143Flattened epiphyses (HP:0003071)1.59598379
144Wormian bones (HP:0002645)1.57797891
145Renal duplication (HP:0000075)1.57514520
146Atelectasis (HP:0100750)1.57058837
147Abnormality of the distal phalanx of the thumb (HP:0009617)1.56756730
148Flat cornea (HP:0007720)1.56514449
149Vertebral compression fractures (HP:0002953)1.56114561
150Advanced eruption of teeth (HP:0006288)1.55756577
151Neonatal death (HP:0003811)1.55481883
152Elbow flexion contracture (HP:0002987)1.54764889
153Hydroureter (HP:0000072)1.54617554
154Abnormality of polysaccharide metabolism (HP:0011012)1.53934816
155Abnormality of glycosaminoglycan metabolism (HP:0004371)1.53934816
156Abnormality of mucopolysaccharide metabolism (HP:0011020)1.53934816
157Acanthosis nigricans (HP:0000956)1.53289501
158Syringomyelia (HP:0003396)1.53254605
159Spinal cord lesions (HP:0100561)1.53254605
160Pseudobulbar signs (HP:0002200)1.52263138
161Limb-girdle muscle atrophy (HP:0003797)1.51890128
162Round ear (HP:0100830)1.51635759
163Visceral angiomatosis (HP:0100761)1.51393370
164Pointed chin (HP:0000307)1.51191491
165Arachnodactyly (HP:0001166)1.51011156

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.33112749
2EPHA23.42611212
3MST1R2.78256288
4TESK22.61916076
5NME22.52681105
6PKN22.50488947
7LRRK22.49811581
8EPHB12.45371652
9ARAF2.43698946
10IRAK32.39116987
11SCYL22.09242556
12TGFBR22.04447810
13LIMK12.02303269
14ERN11.96257247
15EIF2AK11.87051562
16KSR21.86399334
17STK101.83625174
18RIPK11.81181431
19TESK11.78315240
20EPHB21.76264705
21DDR21.68682470
22PAK41.68205842
23PTK61.65992513
24SMG11.65147228
25TYRO31.61607378
26FGFR21.56186071
27MAP3K91.56113669
28KDR1.53282453
29PDGFRA1.50213609
30BMX1.48955531
31ICK1.45564898
32CDK61.36724561
33MAP3K101.33639857
34RPS6KA41.31613286
35TTN1.27760905
36PRPF4B1.25390881
37TAOK11.24781014
38RET1.23673193
39MAP3K121.22765883
40NTRK11.20680736
41ILK1.19827657
42TAOK21.17026379
43KSR11.16934199
44LATS21.16698012
45ABL21.14884095
46FGFR31.12247494
47BLK1.11405357
48MINK11.04978758
49TBK11.02938385
50CAMKK10.99622697
51PAK20.99101840
52MAP3K110.97967465
53BRAF0.97716469
54PDGFRB0.96118118
55FGFR10.95216601
56EPHA30.94899539
57ROCK20.92807476
58PIM20.92755567
59MAP4K10.92566152
60FER0.92449484
61MOS0.91654447
62SIK10.90347421
63MAP3K20.89350903
64UHMK10.89249300
65ERBB40.89208345
66PAK60.88153664
67MYLK0.85929883
68CDK140.84289229
69EEF2K0.83163718
70FES0.82890852
71NEK90.82863585
72MAP3K10.81396264
73PBK0.80689484
74CDK120.79843682
75MATK0.79687608
76PTK2B0.79612875
77NEK10.79376837
78ALK0.79267015
79MET0.78959921
80PRKD30.78917844
81MAP3K30.78513236
82CAMK2G0.78493216
83PRKD10.77658014
84TGFBR10.76757920
85CDK190.75240039
86CAMK1G0.74516460
87* PTK20.74347815
88CSK0.74256693
89MAPKAPK30.74165202
90DYRK1B0.73309565
91CDK80.72645937
92TIE10.72244117
93BRSK10.71054880
94LMTK20.70886201
95LATS10.70560050
96CAMK2B0.67797402
97STK380.67314832
98MTOR0.65554965
99SIK30.65446921
100PRKG20.65385400
101MAP3K80.64737254
102CAMK1D0.64680946
103CDC42BPA0.63856199
104ZAP700.61867579
105JAK30.61619904
106PRKCH0.61550888
107ERBB20.61069367
108ROCK10.60291126
109STK30.60159254
110PAK10.59332601
111MAPKAPK50.58821651
112FYN0.58178155
113CAMKK20.55855031
114CAMK2D0.55815138
115CSNK1A1L0.55612438
116* SRC0.55579341
117AURKA0.55374517
118CDK180.54701503
119EGFR0.52840263
120RPS6KB20.52136945
121MAP3K130.52082196
122CDK150.51446737
123KIT0.50462560
124MAPKAPK20.49592848
125PDPK10.48312085
126FGR0.48177914
127PAK30.46904257
128FGFR40.46668996
129CDK11A0.45632806
130MARK10.45421162
131CSF1R0.45301865
132HCK0.45150098
133BUB10.45000526
134HIPK20.44951782
135RPS6KA20.44292705
136MARK20.43076297
137DAPK10.41853136
138CDK70.40094280
139EPHA40.39245615
140TTK0.37899456
141DAPK30.36405374
142NTRK30.36399202
143PRKD20.35968063
144AKT20.34383073
145STK240.34237099
146RAF10.32868688

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.00831860
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.57233575
3Vibrio cholerae infection_Homo sapiens_hsa051102.24335390
4* Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.19429135
5Prion diseases_Homo sapiens_hsa050201.96511980
6Synaptic vesicle cycle_Homo sapiens_hsa047211.89701043
7Chronic myeloid leukemia_Homo sapiens_hsa052201.73572369
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.72258667
9* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.71853838
10* Leukocyte transendothelial migration_Homo sapiens_hsa046701.57536360
11* Proteoglycans in cancer_Homo sapiens_hsa052051.56187667
12* Shigellosis_Homo sapiens_hsa051311.54912861
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54797734
14* Focal adhesion_Homo sapiens_hsa045101.54477462
15Galactose metabolism_Homo sapiens_hsa000521.51759095
16Platelet activation_Homo sapiens_hsa046111.51569160
17* Adherens junction_Homo sapiens_hsa045201.48661305
18Leishmaniasis_Homo sapiens_hsa051401.44465939
19Glioma_Homo sapiens_hsa052141.43034198
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38758252
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35950547
22* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35836846
23* Pancreatic cancer_Homo sapiens_hsa052121.35238423
24* Renal cell carcinoma_Homo sapiens_hsa052111.34964133
25Pentose phosphate pathway_Homo sapiens_hsa000301.34447916
26Other glycan degradation_Homo sapiens_hsa005111.33116332
27* VEGF signaling pathway_Homo sapiens_hsa043701.33065123
28* Neurotrophin signaling pathway_Homo sapiens_hsa047221.32579337
29Endocytosis_Homo sapiens_hsa041441.31101053
30Endometrial cancer_Homo sapiens_hsa052131.25522558
31Hippo signaling pathway_Homo sapiens_hsa043901.23431865
32Toxoplasmosis_Homo sapiens_hsa051451.23066490
33* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.21057494
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21033535
35Small cell lung cancer_Homo sapiens_hsa052221.20920066
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20847005
37Thyroid cancer_Homo sapiens_hsa052161.19951984
38Bladder cancer_Homo sapiens_hsa052191.19900163
39ECM-receptor interaction_Homo sapiens_hsa045121.19425960
40* Osteoclast differentiation_Homo sapiens_hsa043801.18953504
41Biosynthesis of amino acids_Homo sapiens_hsa012301.18665626
42* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18621721
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.18426582
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17923682
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17633747
46Non-small cell lung cancer_Homo sapiens_hsa052231.17245025
47* Salmonella infection_Homo sapiens_hsa051321.15928143
48MicroRNAs in cancer_Homo sapiens_hsa052061.15694129
49Fructose and mannose metabolism_Homo sapiens_hsa000511.14704983
50* Colorectal cancer_Homo sapiens_hsa052101.14685359
51Pertussis_Homo sapiens_hsa051331.12851940
52Amoebiasis_Homo sapiens_hsa051461.12649025
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10178271
54* Sphingolipid signaling pathway_Homo sapiens_hsa040711.09137918
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06292498
56* Axon guidance_Homo sapiens_hsa043601.06113493
57* Viral myocarditis_Homo sapiens_hsa054161.05967208
58* B cell receptor signaling pathway_Homo sapiens_hsa046621.04283181
59Folate biosynthesis_Homo sapiens_hsa007901.02264492
60* Rap1 signaling pathway_Homo sapiens_hsa040151.01814686
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01533699
62Lysosome_Homo sapiens_hsa041421.00004612
63Acute myeloid leukemia_Homo sapiens_hsa052210.99832762
64Gap junction_Homo sapiens_hsa045400.99659883
65* Chemokine signaling pathway_Homo sapiens_hsa040620.99640676
66Vitamin B6 metabolism_Homo sapiens_hsa007500.98662804
67Dorso-ventral axis formation_Homo sapiens_hsa043200.97593361
68* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97438201
69Hepatitis B_Homo sapiens_hsa051610.97324013
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.97039890
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96237003
72TGF-beta signaling pathway_Homo sapiens_hsa043500.96106449
73Sulfur metabolism_Homo sapiens_hsa009200.95033313
74Tuberculosis_Homo sapiens_hsa051520.92901745
75Estrogen signaling pathway_Homo sapiens_hsa049150.92721697
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92027683
77Prostate cancer_Homo sapiens_hsa052150.89003629
78ErbB signaling pathway_Homo sapiens_hsa040120.88934649
79Melanogenesis_Homo sapiens_hsa049160.88915177
80Gastric acid secretion_Homo sapiens_hsa049710.87482687
81Phenylalanine metabolism_Homo sapiens_hsa003600.86867182
82Carbon metabolism_Homo sapiens_hsa012000.85380229
83Tight junction_Homo sapiens_hsa045300.85316533
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84824239
85Insulin signaling pathway_Homo sapiens_hsa049100.84514047
86* Pathways in cancer_Homo sapiens_hsa052000.84310709
87Arginine and proline metabolism_Homo sapiens_hsa003300.83930855
88Long-term depression_Homo sapiens_hsa047300.82119579
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80950405
90TNF signaling pathway_Homo sapiens_hsa046680.78306740
91Long-term potentiation_Homo sapiens_hsa047200.78283967
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78003763
93GnRH signaling pathway_Homo sapiens_hsa049120.77798436
94Glutathione metabolism_Homo sapiens_hsa004800.77152959
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75831810
96Malaria_Homo sapiens_hsa051440.75775096
97Sulfur relay system_Homo sapiens_hsa041220.75665375
98Dilated cardiomyopathy_Homo sapiens_hsa054140.75209040
99* Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75158691
100T cell receptor signaling pathway_Homo sapiens_hsa046600.74916844
101* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74730218
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74422863
103mTOR signaling pathway_Homo sapiens_hsa041500.72975740
104Basal cell carcinoma_Homo sapiens_hsa052170.72790041
105Sphingolipid metabolism_Homo sapiens_hsa006000.70276845
106Hedgehog signaling pathway_Homo sapiens_hsa043400.70221097
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70139259
108Prolactin signaling pathway_Homo sapiens_hsa049170.69454570
109HIF-1 signaling pathway_Homo sapiens_hsa040660.69422550
110Melanoma_Homo sapiens_hsa052180.69187289
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.68865959
112* Wnt signaling pathway_Homo sapiens_hsa043100.66984543
113Fatty acid elongation_Homo sapiens_hsa000620.66855438
114Oxytocin signaling pathway_Homo sapiens_hsa049210.66685679
115Mineral absorption_Homo sapiens_hsa049780.66254279
116HTLV-I infection_Homo sapiens_hsa051660.65793905
117AMPK signaling pathway_Homo sapiens_hsa041520.65508679
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65399007
119* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64667287
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64659965
121Thyroid hormone synthesis_Homo sapiens_hsa049180.64308245
122Apoptosis_Homo sapiens_hsa042100.64260779
123Hepatitis C_Homo sapiens_hsa051600.63720457
124* Ras signaling pathway_Homo sapiens_hsa040140.62791564
125Cholinergic synapse_Homo sapiens_hsa047250.62728795
126Notch signaling pathway_Homo sapiens_hsa043300.62327831
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.60441036
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60170952
129Dopaminergic synapse_Homo sapiens_hsa047280.59992462
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59304291
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58865104
132* MAPK signaling pathway_Homo sapiens_hsa040100.58223060
133Cocaine addiction_Homo sapiens_hsa050300.58023538
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57399587
135Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56571822
136Collecting duct acid secretion_Homo sapiens_hsa049660.51953450
137* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51137368
138Amphetamine addiction_Homo sapiens_hsa050310.49169259
139N-Glycan biosynthesis_Homo sapiens_hsa005100.48835073
140Bile secretion_Homo sapiens_hsa049760.46390004
141Pyruvate metabolism_Homo sapiens_hsa006200.45728297
142* Phagosome_Homo sapiens_hsa041450.45095015
143Protein digestion and absorption_Homo sapiens_hsa049740.43830292

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