RAC1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.58080275
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.93662806
3ATP synthesis coupled proton transport (GO:0015986)5.93662806
4sequestering of actin monomers (GO:0042989)5.57853692
5DNA deamination (GO:0045006)4.95075180
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.64078422
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.50132677
8chaperone-mediated protein transport (GO:0072321)4.44638348
9protein complex biogenesis (GO:0070271)4.40833982
10respiratory electron transport chain (GO:0022904)4.39618690
11electron transport chain (GO:0022900)4.32745007
12ribosomal small subunit assembly (GO:0000028)4.25490522
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.18062154
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.18062154
15NADH dehydrogenase complex assembly (GO:0010257)4.18062154
16mitochondrial respiratory chain complex assembly (GO:0033108)3.86619643
17cytidine deamination (GO:0009972)3.78703332
18cytidine metabolic process (GO:0046087)3.78703332
19cytidine catabolic process (GO:0006216)3.78703332
20viral transcription (GO:0019083)3.74852905
21platelet dense granule organization (GO:0060155)3.72742214
22translational termination (GO:0006415)3.63560494
23protein localization to cilium (GO:0061512)3.55786231
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.45042517
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.43696379
26tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.43696379
27iron-sulfur cluster assembly (GO:0016226)3.42567160
28metallo-sulfur cluster assembly (GO:0031163)3.42567160
29cotranslational protein targeting to membrane (GO:0006613)3.41915143
30protein-cofactor linkage (GO:0018065)3.36744395
31protein targeting to ER (GO:0045047)3.35931706
32ATP biosynthetic process (GO:0006754)3.28183337
33protein neddylation (GO:0045116)3.26711669
34hydrogen ion transmembrane transport (GO:1902600)3.26530251
35translational elongation (GO:0006414)3.23806427
36pyrimidine ribonucleoside catabolic process (GO:0046133)3.19832115
37nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19725291
38protein localization to endoplasmic reticulum (GO:0070972)3.19394413
39establishment of protein localization to endoplasmic reticulum (GO:0072599)3.18108900
40proteasome assembly (GO:0043248)3.14923166
41proton transport (GO:0015992)3.12480547
42hydrogen transport (GO:0006818)3.08771735
43regulation of activation of Janus kinase activity (GO:0010533)3.08225967
44mannosylation (GO:0097502)3.07650122
45regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.04287424
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.03391927
47GPI anchor metabolic process (GO:0006505)3.03388176
48GPI anchor biosynthetic process (GO:0006506)3.02044930
49behavioral response to nicotine (GO:0035095)3.00179489
50preassembly of GPI anchor in ER membrane (GO:0016254)2.98680924
51purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.97659694
52anterograde synaptic vesicle transport (GO:0048490)2.95498446
53positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.95016852
54purine nucleoside triphosphate biosynthetic process (GO:0009145)2.91545695
55negative regulation of heart rate (GO:0010459)2.90664510
56maturation of SSU-rRNA (GO:0030490)2.86905748
57viral life cycle (GO:0019058)2.85974647
58spliceosomal complex assembly (GO:0000245)2.83453672
59negative regulation of mast cell activation (GO:0033004)2.83032578
60DNA damage response, detection of DNA damage (GO:0042769)2.77633076
61negative regulation of telomere maintenance (GO:0032205)2.75307243
62termination of RNA polymerase III transcription (GO:0006386)2.75108570
63transcription elongation from RNA polymerase III promoter (GO:0006385)2.75108570
64cellular protein complex disassembly (GO:0043624)2.73432578
65regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.69155800
66neuron fate determination (GO:0048664)2.65415499
67nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.64303049
68organelle disassembly (GO:1903008)2.63802274
69respiratory chain complex IV assembly (GO:0008535)2.61295701
70regulation of mitotic spindle checkpoint (GO:1903504)2.60340087
71regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.60340087
72cytochrome complex assembly (GO:0017004)2.57135199
73translational initiation (GO:0006413)2.56437885
74Arp2/3 complex-mediated actin nucleation (GO:0034314)2.55164227
75neural tube formation (GO:0001841)2.53103973
76inner mitochondrial membrane organization (GO:0007007)2.52537421
77ribonucleoprotein complex disassembly (GO:0032988)2.50943832
78translation (GO:0006412)2.48995086
79water-soluble vitamin biosynthetic process (GO:0042364)2.46991698
80spliceosomal snRNP assembly (GO:0000387)2.46919174
81rRNA modification (GO:0000154)2.45810384
82regulation of cilium movement (GO:0003352)2.45792633
83actin nucleation (GO:0045010)2.44909318
84negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.41381793
85ribonucleoside triphosphate biosynthetic process (GO:0009201)2.40750452
86positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.40747139
87spinal cord association neuron differentiation (GO:0021527)2.39868083
88oxidative phosphorylation (GO:0006119)2.36908937
89epithelial cilium movement (GO:0003351)2.35155588
90pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.33017197
91regulation of cellular amino acid metabolic process (GO:0006521)2.32921077
92base-excision repair, AP site formation (GO:0006285)2.32348125
93DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.31558434
94negative regulation of transcription regulatory region DNA binding (GO:2000678)2.31325416
95synaptic transmission, cholinergic (GO:0007271)2.30992987
96pyrimidine nucleobase catabolic process (GO:0006208)2.30866235
97intracellular protein transmembrane import (GO:0044743)2.29723349
98negative regulation by host of viral transcription (GO:0043922)2.29001191
99positive regulation of prostaglandin secretion (GO:0032308)2.28114201
100histone mRNA metabolic process (GO:0008334)2.27983974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.87032703
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.74124121
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.31986511
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.29906477
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.27586679
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.08294113
7EZH2_22144423_ChIP-Seq_EOC_Human3.02426864
8ZNF274_21170338_ChIP-Seq_K562_Hela2.71518457
9VDR_22108803_ChIP-Seq_LS180_Human2.50004777
10TAF15_26573619_Chip-Seq_HEK293_Human2.41674911
11IGF1R_20145208_ChIP-Seq_DFB_Human2.40072314
12VDR_23849224_ChIP-Seq_CD4+_Human2.38690424
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.35883239
14ELK1_19687146_ChIP-ChIP_HELA_Human2.35221340
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.32242995
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.29595904
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14497483
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02013371
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95408960
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94285066
21EWS_26573619_Chip-Seq_HEK293_Human1.88734572
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86726348
23FOXP3_21729870_ChIP-Seq_TREG_Human1.86268404
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84806165
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80843769
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79472489
27TP53_22573176_ChIP-Seq_HFKS_Human1.78693197
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76527823
29FUS_26573619_Chip-Seq_HEK293_Human1.73879330
30MYC_18940864_ChIP-ChIP_HL60_Human1.70188764
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65905643
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63662498
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61439304
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.55460395
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53689054
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.53206879
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.52108237
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.46327761
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44504716
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.41025375
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39032308
42P300_19829295_ChIP-Seq_ESCs_Human1.38571562
43ER_23166858_ChIP-Seq_MCF-7_Human1.38067077
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36824880
45IRF1_19129219_ChIP-ChIP_H3396_Human1.35752444
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35041880
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34777491
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28854321
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.25925833
50SOX2_16153702_ChIP-ChIP_HESCs_Human1.25676410
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25261509
52AR_20517297_ChIP-Seq_VCAP_Human1.22505912
53RNF2_27304074_Chip-Seq_NSC_Mouse1.21470251
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.20762475
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20762475
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.20325411
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19103716
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.15466654
59NANOG_19829295_ChIP-Seq_ESCs_Human1.14602835
60SOX2_19829295_ChIP-Seq_ESCs_Human1.14602835
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12984565
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12430072
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11707022
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11570454
65GBX2_23144817_ChIP-Seq_PC3_Human1.11457088
66TTF2_22483619_ChIP-Seq_HELA_Human1.11114959
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08349377
68GATA3_26560356_Chip-Seq_TH2_Human1.07953473
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07883437
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07445978
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07232526
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07164405
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06654516
74CIITA_25753668_ChIP-Seq_RAJI_Human1.05997045
75MYC_18555785_ChIP-Seq_MESCs_Mouse1.05976532
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03470342
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03221790
78GABP_19822575_ChIP-Seq_HepG2_Human1.02758807
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01527958
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.01367890
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01189269
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99373693
83CBP_20019798_ChIP-Seq_JUKART_Human0.97037087
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97037087
85XRN2_22483619_ChIP-Seq_HELA_Human0.94021635
86NFE2_27457419_Chip-Seq_LIVER_Mouse0.93990479
87NCOR_22424771_ChIP-Seq_293T_Human0.91574109
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90175819
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89856926
90FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88623614
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86641860
92MYC_19829295_ChIP-Seq_ESCs_Human0.86045080
93DCP1A_22483619_ChIP-Seq_HELA_Human0.83917723
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83353291
95ERG_20517297_ChIP-Seq_VCAP_Human0.83188352
96HTT_18923047_ChIP-ChIP_STHdh_Human0.83181108
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82811260
98PCGF2_27294783_Chip-Seq_NPCs_Mouse0.82569736
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82107966
100TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81725647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.04571430
2MP0002277_abnormal_respiratory_mucosa3.02129093
3MP0002102_abnormal_ear_morphology3.00668514
4MP0003880_abnormal_central_pattern2.98027020
5MP0001529_abnormal_vocalization2.90316994
6MP0009379_abnormal_foot_pigmentation2.89871565
7MP0005084_abnormal_gallbladder_morpholo2.63070794
8MP0006292_abnormal_olfactory_placode2.41701451
9MP0006072_abnormal_retinal_apoptosis2.40120158
10MP0008995_early_reproductive_senescence2.00736862
11MP0003724_increased_susceptibility_to1.89382866
12MP0004147_increased_porphyrin_level1.88394370
13MP0004142_abnormal_muscle_tone1.85368733
14MP0009785_altered_susceptibility_to1.83617763
15MP0002653_abnormal_ependyma_morphology1.78517183
16MP0004133_heterotaxia1.76710254
17MP0001835_abnormal_antigen_presentation1.76308610
18MP0005645_abnormal_hypothalamus_physiol1.72604014
19MP0003011_delayed_dark_adaptation1.71563595
20MP0008058_abnormal_DNA_repair1.68367277
21MP0006276_abnormal_autonomic_nervous1.67868899
22MP0002928_abnormal_bile_duct1.67154088
23MP0003136_yellow_coat_color1.61486134
24MP0005551_abnormal_eye_electrophysiolog1.61173938
25MP0008789_abnormal_olfactory_epithelium1.56265613
26MP0001905_abnormal_dopamine_level1.50793540
27MP0005253_abnormal_eye_physiology1.46986041
28MP0002736_abnormal_nociception_after1.41518061
29MP0002735_abnormal_chemical_nociception1.36790008
30MP0008875_abnormal_xenobiotic_pharmacok1.34894254
31MP0001800_abnormal_humoral_immune1.31651924
32MP0001968_abnormal_touch/_nociception1.31127674
33MP0002822_catalepsy1.29279965
34MP0005377_hearing/vestibular/ear_phenot1.27662821
35MP0003878_abnormal_ear_physiology1.27662821
36MP0004145_abnormal_muscle_electrophysio1.26523843
37MP0001984_abnormal_olfaction1.24960608
38MP0002095_abnormal_skin_pigmentation1.24857209
39MP0002132_abnormal_respiratory_system1.24728381
40MP0000631_abnormal_neuroendocrine_gland1.23945200
41MP0001486_abnormal_startle_reflex1.23319332
42MP0003938_abnormal_ear_development1.21997446
43MP0005394_taste/olfaction_phenotype1.21422601
44MP0005499_abnormal_olfactory_system1.21422601
45MP0000372_irregular_coat_pigmentation1.19177104
46MP0001485_abnormal_pinna_reflex1.18614348
47MP0009745_abnormal_behavioral_response1.17539991
48MP0002148_abnormal_hypersensitivity_rea1.17447933
49MP0002272_abnormal_nervous_system1.16173456
50MP0001188_hyperpigmentation1.14352679
51MP0009764_decreased_sensitivity_to1.12018622
52MP0004742_abnormal_vestibular_system1.11750108
53MP0002876_abnormal_thyroid_physiology1.10668295
54MP0003122_maternal_imprinting1.10098305
55MP0003866_abnormal_defecation1.09249276
56MP0003567_abnormal_fetal_cardiomyocyte1.08030502
57MP0002723_abnormal_immune_serum1.08016516
58MP0003806_abnormal_nucleotide_metabolis1.06511501
59MP0001986_abnormal_taste_sensitivity1.06462697
60MP0002638_abnormal_pupillary_reflex1.04832658
61MP0002751_abnormal_autonomic_nervous1.04601245
62MP0005075_abnormal_melanosome_morpholog1.00520069
63MP0005000_abnormal_immune_tolerance0.98355360
64MP0000026_abnormal_inner_ear0.97542513
65MP0001970_abnormal_pain_threshold0.95989908
66MP0000566_synostosis0.94988592
67MP0002452_abnormal_antigen_presenting0.94920530
68MP0002938_white_spotting0.94496984
69MP0001293_anophthalmia0.92430521
70MP0008872_abnormal_physiological_respon0.91172579
71MP0000465_gastrointestinal_hemorrhage0.90534957
72MP0001819_abnormal_immune_cell0.90045207
73MP0001324_abnormal_eye_pigmentation0.89562156
74MP0002420_abnormal_adaptive_immunity0.88345887
75MP0002064_seizures0.87173468
76MP0002282_abnormal_trachea_morphology0.86994809
77MP0002752_abnormal_somatic_nervous0.86987042
78MP0005025_abnormal_response_to0.86772714
79MP0002067_abnormal_sensory_capabilities0.86318112
80MP0003186_abnormal_redox_activity0.85530400
81MP0001790_abnormal_immune_system0.84533304
82MP0005387_immune_system_phenotype0.84533304
83MP0002572_abnormal_emotion/affect_behav0.84401569
84MP0006082_CNS_inflammation0.82405798
85MP0005085_abnormal_gallbladder_physiolo0.82152200
86MP0003786_premature_aging0.81272963
87MP0005167_abnormal_blood-brain_barrier0.79590936
88MP0005195_abnormal_posterior_eye0.79360697
89MP0000647_abnormal_sebaceous_gland0.77456062
90MP0010386_abnormal_urinary_bladder0.76802126
91MP0002234_abnormal_pharynx_morphology0.76091030
92MP0000685_abnormal_immune_system0.76088962
93MP0006035_abnormal_mitochondrial_morpho0.75301752
94MP0000778_abnormal_nervous_system0.75133394
95MP0005646_abnormal_pituitary_gland0.72445283
96MP0001346_abnormal_lacrimal_gland0.72404517
97MP0002734_abnormal_mechanical_nocicepti0.71286874
98MP0009046_muscle_twitch0.70929703
99MP0002733_abnormal_thermal_nociception0.70910171
100MP0008877_abnormal_DNA_methylation0.69115879

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.58788095
2Abnormal mitochondria in muscle tissue (HP:0008316)4.19726359
3Mitochondrial inheritance (HP:0001427)4.06087344
4Acute encephalopathy (HP:0006846)3.79902329
53-Methylglutaconic aciduria (HP:0003535)3.77733693
6Progressive macrocephaly (HP:0004481)3.75047695
7Increased hepatocellular lipid droplets (HP:0006565)3.59255878
8Lipid accumulation in hepatocytes (HP:0006561)3.50632953
9Increased CSF lactate (HP:0002490)3.48717722
10Hepatocellular necrosis (HP:0001404)3.27335899
11Type II lissencephaly (HP:0007260)3.19821746
12Pancreatic cysts (HP:0001737)3.13168884
13True hermaphroditism (HP:0010459)2.97947855
14Hepatic necrosis (HP:0002605)2.97793597
15Renal Fanconi syndrome (HP:0001994)2.94237180
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.90924095
17Decreased activity of mitochondrial respiratory chain (HP:0008972)2.90924095
18Increased intramyocellular lipid droplets (HP:0012240)2.87660536
19Congenital, generalized hypertrichosis (HP:0004540)2.85822017
20Cerebral edema (HP:0002181)2.85552108
21Medial flaring of the eyebrow (HP:0010747)2.84299028
22Abolished electroretinogram (ERG) (HP:0000550)2.78487126
23Aplastic anemia (HP:0001915)2.67712083
24Pancreatic fibrosis (HP:0100732)2.64523807
25Cerebellar dysplasia (HP:0007033)2.60849446
26Retinal dysplasia (HP:0007973)2.60057319
27Optic disc pallor (HP:0000543)2.55438069
28Type 2 muscle fiber atrophy (HP:0003554)2.52622272
29Exertional dyspnea (HP:0002875)2.52355623
30Severe combined immunodeficiency (HP:0004430)2.50552520
31Increased muscle lipid content (HP:0009058)2.47819775
32Abnormal number of erythroid precursors (HP:0012131)2.45308057
33Gait imbalance (HP:0002141)2.45224750
34Abnormality of cells of the erythroid lineage (HP:0012130)2.40006334
35Molar tooth sign on MRI (HP:0002419)2.38267279
36Abnormality of midbrain morphology (HP:0002418)2.38267279
37Congenital primary aphakia (HP:0007707)2.37229576
38Septo-optic dysplasia (HP:0100842)2.35300850
39Congenital stationary night blindness (HP:0007642)2.31407583
40Nephrogenic diabetes insipidus (HP:0009806)2.31324383
41Hypoproteinemia (HP:0003075)2.30396793
42Nephronophthisis (HP:0000090)2.30021205
43IgG deficiency (HP:0004315)2.27005387
44Reticulocytopenia (HP:0001896)2.26651500
45Hypothermia (HP:0002045)2.24997796
46B lymphocytopenia (HP:0010976)2.24243514
47Abnormality of B cell number (HP:0010975)2.22924745
48Decreased central vision (HP:0007663)2.21529133
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20693452
50Lactic acidosis (HP:0003128)2.20454247
51Increased serum lactate (HP:0002151)2.18161952
52Methylmalonic acidemia (HP:0002912)2.14093938
53Panhypogammaglobulinemia (HP:0003139)2.13713974
54Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13514132
55Muscle fiber atrophy (HP:0100295)2.12857977
56Lissencephaly (HP:0001339)2.11983552
57Stomatitis (HP:0010280)2.11421184
58Rib fusion (HP:0000902)2.08487616
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05663986
60Pendular nystagmus (HP:0012043)2.02489140
61Focal motor seizures (HP:0011153)2.01664473
62Pallor (HP:0000980)2.01435081
63Leukodystrophy (HP:0002415)1.99261002
64Attenuation of retinal blood vessels (HP:0007843)1.99227991
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97907738
66Sclerocornea (HP:0000647)1.93215692
67Hypoplasia of the pons (HP:0012110)1.93124862
68Abnormality of the pons (HP:0007361)1.93081952
69Abnormality of the prostate (HP:0008775)1.92938719
70Generalized aminoaciduria (HP:0002909)1.92423250
71Abnormality of renal resorption (HP:0011038)1.92369812
72Macrocytic anemia (HP:0001972)1.89104731
73Respiratory difficulties (HP:0002880)1.87911042
74Exercise intolerance (HP:0003546)1.87604688
75Polyphagia (HP:0002591)1.87586803
76Abnormality of the renal medulla (HP:0100957)1.87454203
77Respiratory failure (HP:0002878)1.86112938
78Limb dystonia (HP:0002451)1.84673006
79Abnormal rod and cone electroretinograms (HP:0008323)1.83998563
80Short tibia (HP:0005736)1.82953776
81Hypochromic microcytic anemia (HP:0004840)1.81947190
82Lethargy (HP:0001254)1.79830845
83Increased IgM level (HP:0003496)1.78364598
84Myokymia (HP:0002411)1.77617871
85Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.77233664
86Vaginal atresia (HP:0000148)1.76731808
87Thyroid-stimulating hormone excess (HP:0002925)1.76689279
88Microvesicular hepatic steatosis (HP:0001414)1.76166466
89Abnormal respiratory motile cilium physiology (HP:0012261)1.75851347
90Abnormal respiratory epithelium morphology (HP:0012253)1.75280665
91Abnormal respiratory motile cilium morphology (HP:0005938)1.75280665
92Combined immunodeficiency (HP:0005387)1.74723190
93Cystic liver disease (HP:0006706)1.74571977
94Concave nail (HP:0001598)1.73449443
95Tubulointerstitial nephritis (HP:0001970)1.73005472
96Anencephaly (HP:0002323)1.72997974
97Methylmalonic aciduria (HP:0012120)1.72260104
98Poor suck (HP:0002033)1.72047023
99Delayed CNS myelination (HP:0002188)1.70854513
100Growth hormone deficiency (HP:0000824)1.69996181

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.61465108
2TXK3.06156868
3CDK192.96121001
4ZAK2.39267659
5BCKDK2.34015447
6TSSK62.19175417
7VRK22.18696444
8DYRK22.18106576
9TESK22.17415082
10SRPK12.16959209
11VRK12.16227458
12MAPK152.15272498
13TRIM282.11218326
14TAOK32.10621582
15ADRBK22.03798393
16WNK31.98259981
17TIE11.94935842
18TLK11.80523575
19MAP3K121.76395378
20BMPR21.71168743
21PINK11.69640880
22BCR1.62803844
23KDR1.62573370
24MAPK131.51833098
25MAP2K71.50110123
26GRK11.49808063
27DYRK31.43780464
28MAP3K41.43709059
29WNK41.29880268
30MARK11.29147937
31INSRR1.23405637
32NUAK11.21850074
33NME11.20783735
34MAP4K11.14043047
35GRK71.11385850
36MATK1.08467313
37CAMKK21.05380939
38FES1.04366749
39BMPR1B1.02968757
40RPS6KA51.02912842
41ERBB31.01767079
42CDK80.97979360
43CSNK1G30.95754864
44STK160.95557027
45RPS6KA40.94871515
46LIMK10.91781479
47CSNK1G20.90666135
48SYK0.89099348
49EPHA30.86653667
50MST40.78568962
51LYN0.75423093
52MARK30.75274888
53CSNK1A1L0.68294308
54OXSR10.67995420
55TEC0.67582840
56RIPK40.65843847
57PRKCE0.65410358
58ITK0.64308104
59GRK60.64068802
60LCK0.63897803
61BLK0.63538471
62CSF1R0.62279267
63IRAK40.62066187
64CSNK1G10.60062134
65MAP3K50.59527957
66MUSK0.58735946
67IKBKB0.58194653
68PRKCQ0.57872524
69PLK40.55712806
70CCNB10.55505987
71PIM10.54075192
72UHMK10.54073495
73ADRBK10.52787418
74CASK0.52257877
75MINK10.50630864
76CSNK2A20.49218442
77EIF2AK30.48767942
78CSNK2A10.45739006
79BTK0.44863965
80PRKCG0.44862709
81PRKG10.44312590
82KIT0.43935025
83PAK30.43043650
84PRKACA0.42246056
85EPHA40.41077939
86DYRK1B0.40838084
87OBSCN0.40561524
88TESK10.39247392
89CAMK2A0.39174251
90MAP2K40.38395499
91CDK140.37125188
92PLK30.36769976
93DYRK1A0.35750082
94IKBKE0.35637308
95ATR0.32396345
96CSK0.32389167
97IGF1R0.31961153
98PLK20.31945797
99CAMK10.31888535
100ZAP700.31857531

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.37606652
2Parkinsons disease_Homo sapiens_hsa050123.79691389
3Ribosome_Homo sapiens_hsa030103.41026715
4Protein export_Homo sapiens_hsa030603.11045453
5Proteasome_Homo sapiens_hsa030503.01503306
6Asthma_Homo sapiens_hsa053102.97437386
7Graft-versus-host disease_Homo sapiens_hsa053322.71898495
8Allograft rejection_Homo sapiens_hsa053302.65179427
9Autoimmune thyroid disease_Homo sapiens_hsa053202.58024606
10Huntingtons disease_Homo sapiens_hsa050162.42436385
11Alzheimers disease_Homo sapiens_hsa050102.39551566
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.27986800
13Type I diabetes mellitus_Homo sapiens_hsa049402.25699418
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.14733231
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09542486
16Primary immunodeficiency_Homo sapiens_hsa053401.95914279
17Cardiac muscle contraction_Homo sapiens_hsa042601.93655331
18Antigen processing and presentation_Homo sapiens_hsa046121.89834703
19RNA polymerase_Homo sapiens_hsa030201.87015310
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73629063
21Rheumatoid arthritis_Homo sapiens_hsa053231.67413386
22Phototransduction_Homo sapiens_hsa047441.60008186
23Spliceosome_Homo sapiens_hsa030401.47335799
24Homologous recombination_Homo sapiens_hsa034401.45468177
25Basal transcription factors_Homo sapiens_hsa030221.41736463
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38715189
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28076444
28RNA degradation_Homo sapiens_hsa030181.27320232
29Systemic lupus erythematosus_Homo sapiens_hsa053221.26938264
30Sulfur metabolism_Homo sapiens_hsa009201.26177109
31Regulation of autophagy_Homo sapiens_hsa041401.20499520
32Nicotine addiction_Homo sapiens_hsa050331.12922808
33Viral myocarditis_Homo sapiens_hsa054161.10086455
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09383430
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04118320
36Staphylococcus aureus infection_Homo sapiens_hsa051501.03459450
37Leishmaniasis_Homo sapiens_hsa051400.99483905
38Hematopoietic cell lineage_Homo sapiens_hsa046400.98251740
39Maturity onset diabetes of the young_Homo sapiens_hsa049500.92479912
40Collecting duct acid secretion_Homo sapiens_hsa049660.89778295
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89685736
42Sulfur relay system_Homo sapiens_hsa041220.86235415
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85033421
44Fanconi anemia pathway_Homo sapiens_hsa034600.84753272
45Nitrogen metabolism_Homo sapiens_hsa009100.83816210
46Nucleotide excision repair_Homo sapiens_hsa034200.81371129
47Base excision repair_Homo sapiens_hsa034100.78356218
48Mismatch repair_Homo sapiens_hsa034300.78330654
49Butanoate metabolism_Homo sapiens_hsa006500.76198236
50Peroxisome_Homo sapiens_hsa041460.74781987
51Phagosome_Homo sapiens_hsa041450.73307339
52Pyrimidine metabolism_Homo sapiens_hsa002400.70658378
53Non-homologous end-joining_Homo sapiens_hsa034500.69103112
54Olfactory transduction_Homo sapiens_hsa047400.65643198
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60770950
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60641825
57Taste transduction_Homo sapiens_hsa047420.60259617
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59964501
59GABAergic synapse_Homo sapiens_hsa047270.59254048
60Purine metabolism_Homo sapiens_hsa002300.58754009
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58152435
62Linoleic acid metabolism_Homo sapiens_hsa005910.58100401
63Epstein-Barr virus infection_Homo sapiens_hsa051690.57081559
64Alcoholism_Homo sapiens_hsa050340.56470845
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52985593
66Legionellosis_Homo sapiens_hsa051340.51962009
67Salmonella infection_Homo sapiens_hsa051320.48983845
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48288305
69RNA transport_Homo sapiens_hsa030130.48234096
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47684192
71Metabolic pathways_Homo sapiens_hsa011000.46926421
72Folate biosynthesis_Homo sapiens_hsa007900.46205473
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45588653
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45487821
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45417174
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44967000
77Propanoate metabolism_Homo sapiens_hsa006400.44327750
78Herpes simplex infection_Homo sapiens_hsa051680.43536436
79One carbon pool by folate_Homo sapiens_hsa006700.40546914
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39927071
81Tuberculosis_Homo sapiens_hsa051520.39872271
82Arachidonic acid metabolism_Homo sapiens_hsa005900.39710177
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36154869
84Selenocompound metabolism_Homo sapiens_hsa004500.35334617
85DNA replication_Homo sapiens_hsa030300.33745708
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.33724102
87Tryptophan metabolism_Homo sapiens_hsa003800.33689131
88Morphine addiction_Homo sapiens_hsa050320.33597627
89Chemical carcinogenesis_Homo sapiens_hsa052040.32401051
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31465458
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31419785
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.30976779
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.30735622
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29298121
95African trypanosomiasis_Homo sapiens_hsa051430.28273501
96Shigellosis_Homo sapiens_hsa051310.26328864
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25802495
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24860659
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23181782
100Cocaine addiction_Homo sapiens_hsa050300.21763172

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