RAC1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)6.21783344
2cytidine deamination (GO:0009972)5.44172243
3cytidine metabolic process (GO:0046087)5.44172243
4cytidine catabolic process (GO:0006216)5.44172243
5pyrimidine ribonucleoside catabolic process (GO:0046133)5.21532111
6establishment of protein localization to mitochondrial membrane (GO:0090151)5.15411125
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.93855870
8spinal cord association neuron differentiation (GO:0021527)4.55107413
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.46991940
10ATP synthesis coupled proton transport (GO:0015986)4.46991940
11DNA deamination (GO:0045006)4.38909570
12urinary tract smooth muscle contraction (GO:0014848)4.08713931
13pyrimidine nucleobase catabolic process (GO:0006208)3.97116195
14substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.95436224
15substrate-independent telencephalic tangential migration (GO:0021826)3.95436224
16cerebellar Purkinje cell layer development (GO:0021680)3.82444992
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.81277744
18protein neddylation (GO:0045116)3.80828622
19respiratory electron transport chain (GO:0022904)3.75705340
20electron transport chain (GO:0022900)3.73507164
21nephron tubule morphogenesis (GO:0072078)3.71517521
22nephron epithelium morphogenesis (GO:0072088)3.71517521
23regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.62506757
24water-soluble vitamin biosynthetic process (GO:0042364)3.59270946
25toxin metabolic process (GO:0009404)3.58836219
26peristalsis (GO:0030432)3.58014173
27positive regulation of calcium-mediated signaling (GO:0050850)3.56540098
28preassembly of GPI anchor in ER membrane (GO:0016254)3.49418885
29response to histamine (GO:0034776)3.47561831
30nonmotile primary cilium assembly (GO:0035058)3.40726174
31neuronal action potential (GO:0019228)3.36109927
32short-term memory (GO:0007614)3.32866213
33GPI anchor metabolic process (GO:0006505)3.25005275
34regulation of glucokinase activity (GO:0033131)3.21268798
35regulation of hexokinase activity (GO:1903299)3.21268798
36nucleobase catabolic process (GO:0046113)3.19572078
37DNA demethylation (GO:0080111)3.15068650
38DNA integration (GO:0015074)3.14835428
39behavioral response to nicotine (GO:0035095)3.14471329
40GPI anchor biosynthetic process (GO:0006506)3.05164397
41cellular response to nicotine (GO:0071316)3.03983849
42phosphorelay signal transduction system (GO:0000160)3.03283902
43pyrimidine-containing compound catabolic process (GO:0072529)2.98427423
44regulation of cell fate specification (GO:0042659)2.97716808
45regulation of cell fate commitment (GO:0010453)2.97451978
46chaperone-mediated protein transport (GO:0072321)2.96296825
47regulation of mesoderm development (GO:2000380)2.93236613
48positive regulation of prostaglandin secretion (GO:0032308)2.91336096
49regulation of meiosis I (GO:0060631)2.90914843
50hydrogen ion transmembrane transport (GO:1902600)2.90380911
51eosinophil chemotaxis (GO:0048245)2.89963962
52mannosylation (GO:0097502)2.86825345
53proton transport (GO:0015992)2.85956970
54epithelial cell maturation (GO:0002070)2.84294366
55platelet dense granule organization (GO:0060155)2.83806079
56iron-sulfur cluster assembly (GO:0016226)2.83022925
57metallo-sulfur cluster assembly (GO:0031163)2.83022925
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80679583
59mitochondrial respiratory chain complex I assembly (GO:0032981)2.80679583
60NADH dehydrogenase complex assembly (GO:0010257)2.80679583
61ATP biosynthetic process (GO:0006754)2.80037790
62hydrogen transport (GO:0006818)2.77657616
63negative regulation of mast cell activation (GO:0033004)2.76870108
64protein complex biogenesis (GO:0070271)2.75262134
65neurofilament cytoskeleton organization (GO:0060052)2.74981379
66cilium morphogenesis (GO:0060271)2.74188742
67vocalization behavior (GO:0071625)2.72192057
68inner ear receptor stereocilium organization (GO:0060122)2.71439095
69neuron cell-cell adhesion (GO:0007158)2.71118846
70positive regulation of fatty acid transport (GO:2000193)2.69941809
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.69650152
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.69650152
73negative regulation by host of viral transcription (GO:0043922)2.68426180
74positive regulation of interleukin-8 secretion (GO:2000484)2.67790121
75pyrimidine nucleoside catabolic process (GO:0046135)2.67680191
76positive regulation of dendritic spine morphogenesis (GO:0061003)2.67648013
77purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.67113250
78RNA destabilization (GO:0050779)2.64981481
79negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.64021939
80endoderm formation (GO:0001706)2.63445263
81eosinophil migration (GO:0072677)2.62385591
82DNA dealkylation (GO:0035510)2.62237706
83response to nicotine (GO:0035094)2.61664629
84anterograde synaptic vesicle transport (GO:0048490)2.58558969
85regulation of calcium-mediated signaling (GO:0050848)2.58017101
86purine nucleoside triphosphate biosynthetic process (GO:0009145)2.55652098
87transmission of nerve impulse (GO:0019226)2.54122062
88inner ear receptor cell development (GO:0060119)2.54110198
89regulation of transcription involved in cell fate commitment (GO:0060850)2.52871781
90neuromuscular synaptic transmission (GO:0007274)2.49899798
91renal tubule morphogenesis (GO:0061333)2.48705303
92regulation of synapse structural plasticity (GO:0051823)2.48666461
93axonemal dynein complex assembly (GO:0070286)2.48603764
94cilium movement (GO:0003341)2.48599308
95protein localization to cilium (GO:0061512)2.47937444
96hypothalamus development (GO:0021854)2.47361012
97negative regulation of glial cell differentiation (GO:0045686)2.46946812
98cell differentiation in spinal cord (GO:0021515)2.45230004
99detection of light stimulus involved in sensory perception (GO:0050962)2.45183850
100detection of light stimulus involved in visual perception (GO:0050908)2.45183850

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.98302245
2TAF15_26573619_Chip-Seq_HEK293_Human3.52835045
3ZNF274_21170338_ChIP-Seq_K562_Hela3.37499489
4GBX2_23144817_ChIP-Seq_PC3_Human3.06644502
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.89652892
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.87122113
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67619475
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.65978208
9VDR_22108803_ChIP-Seq_LS180_Human2.53697454
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.47057176
11IGF1R_20145208_ChIP-Seq_DFB_Human2.18958160
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18571641
13RNF2_27304074_Chip-Seq_NSC_Mouse2.17861610
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09716247
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05239083
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.97815905
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94096350
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92883869
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86770977
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85333627
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82426390
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81975902
23EWS_26573619_Chip-Seq_HEK293_Human1.80489950
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.75317817
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.69118896
26MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.68485803
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66748698
28P300_19829295_ChIP-Seq_ESCs_Human1.66349808
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63878124
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.63872000
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63068122
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61154075
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59718513
34REST_21632747_ChIP-Seq_MESCs_Mouse1.56501578
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.54785177
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.53611857
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51030346
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49570483
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49541096
40MYC_18940864_ChIP-ChIP_HL60_Human1.48963408
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47749603
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.46898122
43FUS_26573619_Chip-Seq_HEK293_Human1.45529650
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.45483773
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41035409
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40119439
47TP53_22573176_ChIP-Seq_HFKS_Human1.38968647
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37904426
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37103767
50AR_21572438_ChIP-Seq_LNCaP_Human1.35594817
51BCAT_22108803_ChIP-Seq_LS180_Human1.35058400
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35037838
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34151691
54ER_23166858_ChIP-Seq_MCF-7_Human1.31491345
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29607068
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29607068
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29158793
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23665633
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23665633
60SMAD4_21799915_ChIP-Seq_A2780_Human1.23609987
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22737901
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22102515
63SOX2_19829295_ChIP-Seq_ESCs_Human1.20999917
64NANOG_19829295_ChIP-Seq_ESCs_Human1.20999917
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15647421
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.15019277
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14264349
68AR_25329375_ChIP-Seq_VCAP_Human1.14066457
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13246249
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.12723880
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11857723
72SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11712681
73EST1_17652178_ChIP-ChIP_JURKAT_Human1.11063862
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.11016140
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10060209
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09618582
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.08678029
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.08304233
79TAL1_26923725_Chip-Seq_HPCs_Mouse1.07849078
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07655164
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05408079
82MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05097764
83IRF8_21731497_ChIP-ChIP_J774_Mouse1.04549371
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03471877
85TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03310841
86CBP_20019798_ChIP-Seq_JUKART_Human1.01801672
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01801672
88ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00176089
89TAF2_19829295_ChIP-Seq_ESCs_Human1.00042655
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99810015
91STAT3_23295773_ChIP-Seq_U87_Human0.98809464
92P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98701886
93SMAD4_21741376_ChIP-Seq_EPCs_Human0.95412615
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95262018
95RUNX2_22187159_ChIP-Seq_PCA_Human0.94318763
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93064478
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92917067
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90295022
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.90161617
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89112099

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.97343389
2MP0004147_increased_porphyrin_level3.21118950
3MP0002736_abnormal_nociception_after2.87882408
4MP0005423_abnormal_somatic_nervous2.79751830
5MP0001968_abnormal_touch/_nociception2.76807873
6MP0003122_maternal_imprinting2.75203101
7MP0005377_hearing/vestibular/ear_phenot2.65840603
8MP0003878_abnormal_ear_physiology2.65840603
9MP0004133_heterotaxia2.58931281
10MP0003880_abnormal_central_pattern2.57237028
11MP0008875_abnormal_xenobiotic_pharmacok2.56956723
12MP0008877_abnormal_DNA_methylation2.34516007
13MP0006292_abnormal_olfactory_placode2.32657668
14MP0003121_genomic_imprinting2.24164023
15MP0002163_abnormal_gland_morphology2.08075819
16MP0002102_abnormal_ear_morphology2.04759241
17MP0000372_irregular_coat_pigmentation2.03728730
18MP0001188_hyperpigmentation2.01632476
19MP0002653_abnormal_ependyma_morphology1.97525922
20MP0009379_abnormal_foot_pigmentation1.92351804
21MP0003567_abnormal_fetal_cardiomyocyte1.80222247
22MP0001984_abnormal_olfaction1.77615104
23MP0002735_abnormal_chemical_nociception1.76128547
24MP0004742_abnormal_vestibular_system1.74785910
25MP0005084_abnormal_gallbladder_morpholo1.72055658
26MP0009745_abnormal_behavioral_response1.65185563
27MP0003123_paternal_imprinting1.61879169
28MP0005379_endocrine/exocrine_gland_phen1.61836969
29MP0005551_abnormal_eye_electrophysiolog1.60347743
30MP0002234_abnormal_pharynx_morphology1.60252694
31MP0001486_abnormal_startle_reflex1.60122457
32MP0001529_abnormal_vocalization1.57817878
33MP0001346_abnormal_lacrimal_gland1.55361144
34MP0006072_abnormal_retinal_apoptosis1.49293194
35MP0005671_abnormal_response_to1.48348810
36MP0002009_preneoplasia1.42760538
37MP0002272_abnormal_nervous_system1.40308683
38MP0000026_abnormal_inner_ear1.38092776
39MP0001485_abnormal_pinna_reflex1.37551767
40MP0002734_abnormal_mechanical_nocicepti1.36468457
41MP0006276_abnormal_autonomic_nervous1.36186485
42MP0002938_white_spotting1.34938541
43MP0001905_abnormal_dopamine_level1.31625836
44MP0002822_catalepsy1.28479710
45MP0000631_abnormal_neuroendocrine_gland1.27522959
46MP0005248_abnormal_Harderian_gland1.26950726
47MP0002067_abnormal_sensory_capabilities1.24105962
48MP0000049_abnormal_middle_ear1.22965929
49MP0001970_abnormal_pain_threshold1.20471511
50MP0004145_abnormal_muscle_electrophysio1.20110159
51MP0002064_seizures1.19818574
52MP0004885_abnormal_endolymph1.18594932
53MP0002572_abnormal_emotion/affect_behav1.16442336
54MP0003938_abnormal_ear_development1.15070281
55MP0002733_abnormal_thermal_nociception1.14502303
56MP0003937_abnormal_limbs/digits/tail_de1.11886174
57MP0001986_abnormal_taste_sensitivity1.09675674
58MP0003635_abnormal_synaptic_transmissio1.09043026
59MP0000566_synostosis1.07509062
60MP0005253_abnormal_eye_physiology1.06836551
61MP0001293_anophthalmia1.06724242
62MP0002557_abnormal_social/conspecific_i1.03902867
63MP0003011_delayed_dark_adaptation1.03531302
64MP0002752_abnormal_somatic_nervous1.03396091
65MP0002063_abnormal_learning/memory/cond1.02431615
66MP0008789_abnormal_olfactory_epithelium1.02259290
67MP0009250_abnormal_appendicular_skeleto1.01531968
68MP0003890_abnormal_embryonic-extraembry1.00664276
69MP0004142_abnormal_muscle_tone1.00453003
70MP0002909_abnormal_adrenal_gland0.99837545
71MP0002932_abnormal_joint_morphology0.99658714
72MP0005499_abnormal_olfactory_system0.97363929
73MP0005394_taste/olfaction_phenotype0.97363929
74MP0000778_abnormal_nervous_system0.95803503
75MP0005645_abnormal_hypothalamus_physiol0.95763141
76MP0001501_abnormal_sleep_pattern0.95473290
77MP0002277_abnormal_respiratory_mucosa0.92953697
78MP0001963_abnormal_hearing_physiology0.92829667
79MP0000955_abnormal_spinal_cord0.91652074
80MP0002233_abnormal_nose_morphology0.90795268
81MP0005195_abnormal_posterior_eye0.89886200
82MP0004043_abnormal_pH_regulation0.89633489
83MP0000383_abnormal_hair_follicle0.88451225
84MP0001502_abnormal_circadian_rhythm0.88229429
85MP0001299_abnormal_eye_distance/0.87198311
86MP0002876_abnormal_thyroid_physiology0.86861457
87MP0003866_abnormal_defecation0.86156809
88MP0008872_abnormal_physiological_respon0.81963109
89MP0000647_abnormal_sebaceous_gland0.81401991
90MP0009046_muscle_twitch0.77788062
91MP0002184_abnormal_innervation0.73560178
92MP0002882_abnormal_neuron_morphology0.72440926
93MP0005386_behavior/neurological_phenoty0.71857734
94MP0004924_abnormal_behavior0.71857734
95MP0000579_abnormal_nail_morphology0.70530753
96MP0003119_abnormal_digestive_system0.69754854
97MP0001324_abnormal_eye_pigmentation0.69135915
98MP0000427_abnormal_hair_cycle0.68834595
99MP0008569_lethality_at_weaning0.67733229
100MP0009384_cardiac_valve_regurgitation0.65798786

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)4.79100225
2Acute necrotizing encephalopathy (HP:0006965)4.21359959
3Molar tooth sign on MRI (HP:0002419)4.21150755
4Abnormality of midbrain morphology (HP:0002418)4.21150755
5Pancreatic cysts (HP:0001737)3.96012570
6Pancreatic fibrosis (HP:0100732)3.80245714
7Abnormal biliary tract physiology (HP:0012439)3.74664872
8Bile duct proliferation (HP:0001408)3.74664872
9Progressive macrocephaly (HP:0004481)3.54749516
10Septo-optic dysplasia (HP:0100842)3.50660846
11Abnormal mitochondria in muscle tissue (HP:0008316)3.48658229
12Acute encephalopathy (HP:0006846)3.43033935
13Mitochondrial inheritance (HP:0001427)3.41920320
14Gait imbalance (HP:0002141)3.17374618
15Nephronophthisis (HP:0000090)3.15496739
16Medial flaring of the eyebrow (HP:0010747)3.11528132
17Colon cancer (HP:0003003)3.10483827
18Limb dystonia (HP:0002451)3.04957612
19Renal Fanconi syndrome (HP:0001994)3.03859251
20Increased hepatocellular lipid droplets (HP:0006565)3.02431307
21Congenital primary aphakia (HP:0007707)2.94831167
22Sclerocornea (HP:0000647)2.84547557
23Congenital stationary night blindness (HP:0007642)2.81450782
243-Methylglutaconic aciduria (HP:0003535)2.81448777
25Male pseudohermaphroditism (HP:0000037)2.66360466
26Nephrogenic diabetes insipidus (HP:0009806)2.64241298
27Lipid accumulation in hepatocytes (HP:0006561)2.61955037
28Chronic hepatic failure (HP:0100626)2.61091548
29Vaginal atresia (HP:0000148)2.60954412
30Increased CSF lactate (HP:0002490)2.59756550
31Genital tract atresia (HP:0001827)2.52172135
32Abnormality of the renal medulla (HP:0100957)2.46541502
33Cystic liver disease (HP:0006706)2.46264148
34Renal cortical cysts (HP:0000803)2.43389140
35Absent septum pellucidum (HP:0001331)2.43341700
36Rectal prolapse (HP:0002035)2.38210064
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.38101640
38Absent rod-and cone-mediated responses on ERG (HP:0007688)2.37134787
39Hyperventilation (HP:0002883)2.36355253
40Cerebral edema (HP:0002181)2.34289926
41Abnormal respiratory motile cilium physiology (HP:0012261)2.29737582
42Broad-based gait (HP:0002136)2.28538787
43Anencephaly (HP:0002323)2.28334802
44Protruding tongue (HP:0010808)2.27215271
45Increased intramyocellular lipid droplets (HP:0012240)2.23714229
46Abnormal rod and cone electroretinograms (HP:0008323)2.17380975
47Tachypnea (HP:0002789)2.14550652
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.14118857
49Decreased activity of mitochondrial respiratory chain (HP:0008972)2.14118857
50Tented upper lip vermilion (HP:0010804)2.12509650
51Abnormality of the septum pellucidum (HP:0007375)2.09623773
52Abnormality of the renal cortex (HP:0011035)2.09245766
53Aplasia/Hypoplasia of the tongue (HP:0010295)2.09228151
54Optic disc pallor (HP:0000543)2.08924524
55Abnormality of urine glucose concentration (HP:0011016)2.06298334
56Glycosuria (HP:0003076)2.06298334
57Decreased central vision (HP:0007663)2.05801625
58Hepatic necrosis (HP:0002605)2.05058255
59Hepatocellular necrosis (HP:0001404)2.04857412
60Supernumerary spleens (HP:0009799)2.02823169
61Generalized aminoaciduria (HP:0002909)1.97900022
62Methylmalonic acidemia (HP:0002912)1.95885698
63Abolished electroretinogram (ERG) (HP:0000550)1.94391082
64Optic nerve coloboma (HP:0000588)1.94312585
65Adrenal hypoplasia (HP:0000835)1.93389677
66Pachygyria (HP:0001302)1.92424188
67Poor coordination (HP:0002370)1.92373256
68Postaxial foot polydactyly (HP:0001830)1.91275594
69Carpal bone hypoplasia (HP:0001498)1.89749494
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89458300
71Recurrent corneal erosions (HP:0000495)1.89441378
72Congenital, generalized hypertrichosis (HP:0004540)1.87595473
73Leukodystrophy (HP:0002415)1.86603240
74Concave nail (HP:0001598)1.85700859
75Optic nerve hypoplasia (HP:0000609)1.85458200
76Sex reversal (HP:0012245)1.85231735
77Abnormal sex determination (HP:0012244)1.85231735
78Cortical dysplasia (HP:0002539)1.84341574
79Abnormal ciliary motility (HP:0012262)1.83079196
80Pendular nystagmus (HP:0012043)1.82373920
81Degeneration of the lateral corticospinal tracts (HP:0002314)1.82182034
82Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.82182034
83Congenital hepatic fibrosis (HP:0002612)1.81677454
84Infantile muscular hypotonia (HP:0008947)1.81209612
85Hemiplegia (HP:0002301)1.80975858
86Abnormality of renal resorption (HP:0011038)1.80606811
87Polyphagia (HP:0002591)1.79833237
88Type II lissencephaly (HP:0007260)1.78873690
89Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78803282
90Occipital encephalocele (HP:0002085)1.78604579
91Furrowed tongue (HP:0000221)1.78256270
92Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76200621
93Abnormality of the labia minora (HP:0012880)1.74452842
94Abnormal respiratory epithelium morphology (HP:0012253)1.74296861
95Abnormal respiratory motile cilium morphology (HP:0005938)1.74296861
96Lissencephaly (HP:0001339)1.73976527
97Shawl scrotum (HP:0000049)1.72909910
98Hyperphosphaturia (HP:0003109)1.71230913
99Rhinitis (HP:0012384)1.70789617
100Narrow forehead (HP:0000341)1.70744388

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK14.06825977
2ZAK3.76747955
3ADRBK23.37780633
4TXK3.24563718
5PINK13.10020548
6LIMK12.78568516
7WNK32.73948314
8CASK2.73924695
9PNCK2.66338700
10WNK42.58413293
11TAF12.57054888
12MARK12.43852258
13MAP4K22.29924651
14TRIM282.28267279
15MAP3K42.05067881
16KDR1.99692204
17BMPR1B1.99119580
18DYRK31.97960805
19TLK11.90698836
20DYRK21.87961542
21GRK11.62725741
22NME11.58600785
23TIE11.52967573
24MAPK131.52880298
25MATK1.42971730
26NUAK11.42637906
27TNIK1.37570751
28VRK21.35591759
29TAOK31.32128732
30TYRO31.25794628
31PIK3CA1.23348269
32FRK1.21344124
33MKNK21.14765918
34BCKDK1.13173704
35MINK11.07914400
36MAPKAPK51.04645390
37NTRK31.04540555
38BRSK20.96879062
39CAMK2A0.96441576
40SRPK10.96049492
41EPHA40.94758937
42MKNK10.92519001
43VRK10.85963659
44MAP2K70.82378916
45STK110.79693122
46BUB10.76567911
47DYRK1B0.73255629
48MAP3K90.70642280
49MAPK150.64864956
50MAP3K120.64616724
51BCR0.63976077
52STK160.61156568
53WEE10.59812649
54MAP4K10.59623441
55PHKG10.58966550
56PHKG20.58966550
57CAMKK20.57716093
58BMPR20.57538146
59DMPK0.56473626
60NTRK20.56383020
61UHMK10.55348694
62CAMK2B0.54820591
63MAP3K110.54784385
64CAMK2D0.50816563
65CSNK1G20.49986872
66ADRBK10.48136060
67PRKCQ0.47125897
68SYK0.46524232
69PRKCG0.44801301
70MARK20.43527039
71EIF2AK30.43289905
72ITK0.41772762
73CDK90.40969792
74PIM10.40377134
75GRK50.40275182
76LCK0.38252889
77PRKACA0.38211891
78NTRK10.37694775
79CSNK1A10.35660708
80CCNB10.35088548
81PLK30.30800870
82NEK20.30786858
83CDK190.30632841
84PRKCE0.30580812
85TESK20.29737359
86INSRR0.29478624
87CDK50.28954217
88CSNK1E0.28441849
89FYN0.27993188
90CSNK1G30.27809922
91CHEK20.27621305
92CAMK2G0.25721851
93OBSCN0.25608915
94PRKCA0.25336131
95MAP3K60.25167473
96TESK10.24838200
97GRK70.24509492
98PRKG10.24475700
99RPS6KA50.23770524
100AURKB0.23540359

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.19041000
2Parkinsons disease_Homo sapiens_hsa050123.61622375
3Protein export_Homo sapiens_hsa030603.15703696
4Cardiac muscle contraction_Homo sapiens_hsa042602.61276632
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.59025740
6Nicotine addiction_Homo sapiens_hsa050332.54621216
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.53089748
8Sulfur metabolism_Homo sapiens_hsa009202.45290272
9Ribosome_Homo sapiens_hsa030102.39638166
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.34538959
11Alzheimers disease_Homo sapiens_hsa050102.32559718
12Huntingtons disease_Homo sapiens_hsa050162.27014952
13Primary immunodeficiency_Homo sapiens_hsa053402.23354244
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.04292096
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.96578048
16Phototransduction_Homo sapiens_hsa047441.89020357
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67590866
18Graft-versus-host disease_Homo sapiens_hsa053321.67146678
19GABAergic synapse_Homo sapiens_hsa047271.57676182
20Autoimmune thyroid disease_Homo sapiens_hsa053201.57141216
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.56443506
22Linoleic acid metabolism_Homo sapiens_hsa005911.54419450
23Morphine addiction_Homo sapiens_hsa050321.52530123
24Allograft rejection_Homo sapiens_hsa053301.51634933
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42329774
26Asthma_Homo sapiens_hsa053101.39531087
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31006939
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.29765261
29Rheumatoid arthritis_Homo sapiens_hsa053231.26324668
30Type I diabetes mellitus_Homo sapiens_hsa049401.24191810
31Nitrogen metabolism_Homo sapiens_hsa009101.21519738
32Taste transduction_Homo sapiens_hsa047421.19691750
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.17973664
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14583158
35Butanoate metabolism_Homo sapiens_hsa006501.12816284
36RNA polymerase_Homo sapiens_hsa030201.11292573
37Caffeine metabolism_Homo sapiens_hsa002321.09893532
38Hematopoietic cell lineage_Homo sapiens_hsa046401.07884931
39Basal transcription factors_Homo sapiens_hsa030221.07059105
40Olfactory transduction_Homo sapiens_hsa047401.01977837
41Proteasome_Homo sapiens_hsa030501.01731116
42Antigen processing and presentation_Homo sapiens_hsa046120.95443669
43Collecting duct acid secretion_Homo sapiens_hsa049660.92411296
44Peroxisome_Homo sapiens_hsa041460.90019410
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89159597
46Dopaminergic synapse_Homo sapiens_hsa047280.87715580
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86266284
48Fatty acid biosynthesis_Homo sapiens_hsa000610.83094330
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.82522162
50Ether lipid metabolism_Homo sapiens_hsa005650.81046954
51Glutamatergic synapse_Homo sapiens_hsa047240.79730252
52Cocaine addiction_Homo sapiens_hsa050300.77200950
53Salmonella infection_Homo sapiens_hsa051320.72717244
54Serotonergic synapse_Homo sapiens_hsa047260.72688005
55Circadian entrainment_Homo sapiens_hsa047130.70444022
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.68247441
57Amphetamine addiction_Homo sapiens_hsa050310.65804531
58RNA degradation_Homo sapiens_hsa030180.65713676
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63410849
60Mineral absorption_Homo sapiens_hsa049780.63350819
61Tryptophan metabolism_Homo sapiens_hsa003800.59874759
62Steroid biosynthesis_Homo sapiens_hsa001000.59227405
63Insulin secretion_Homo sapiens_hsa049110.56319598
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56169320
65Cholinergic synapse_Homo sapiens_hsa047250.54204483
66Homologous recombination_Homo sapiens_hsa034400.53123730
67Chemical carcinogenesis_Homo sapiens_hsa052040.53105150
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50846602
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50381556
70Purine metabolism_Homo sapiens_hsa002300.48764922
71Mismatch repair_Homo sapiens_hsa034300.48675187
72Fat digestion and absorption_Homo sapiens_hsa049750.48258665
73Metabolic pathways_Homo sapiens_hsa011000.47077077
74Alcoholism_Homo sapiens_hsa050340.47060767
75Gastric acid secretion_Homo sapiens_hsa049710.46994200
76cAMP signaling pathway_Homo sapiens_hsa040240.45855077
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43676123
78Retinol metabolism_Homo sapiens_hsa008300.41640384
79Tyrosine metabolism_Homo sapiens_hsa003500.41340146
80Systemic lupus erythematosus_Homo sapiens_hsa053220.41322438
81Nucleotide excision repair_Homo sapiens_hsa034200.40618641
82Bile secretion_Homo sapiens_hsa049760.40534493
83beta-Alanine metabolism_Homo sapiens_hsa004100.39836343
84Salivary secretion_Homo sapiens_hsa049700.38982910
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38805222
86Axon guidance_Homo sapiens_hsa043600.36872476
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36613744
88Arachidonic acid metabolism_Homo sapiens_hsa005900.33958014
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33355204
90Selenocompound metabolism_Homo sapiens_hsa004500.33076269
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32547586
92Calcium signaling pathway_Homo sapiens_hsa040200.32032819
93Fanconi anemia pathway_Homo sapiens_hsa034600.31687094
94Viral myocarditis_Homo sapiens_hsa054160.30999892
95Phenylalanine metabolism_Homo sapiens_hsa003600.30801176
96Spliceosome_Homo sapiens_hsa030400.29984533
97Pancreatic secretion_Homo sapiens_hsa049720.29395974
98Pyrimidine metabolism_Homo sapiens_hsa002400.28832025
99Phagosome_Homo sapiens_hsa041450.28359060
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28071027

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »