RAC1P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.35727492
2RNA localization (GO:0006403)7.75190187
3negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 6.84534593
4positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)6.80679265
5ribosomal small subunit biogenesis (GO:0042274)6.79803930
6maturation of 5.8S rRNA (GO:0000460)6.78532782
7establishment of protein localization to mitochondrial membrane (GO:0090151)6.56362870
8signal complex assembly (GO:0007172)6.44736336
9viral transcription (GO:0019083)6.22124882
10positive regulation of translational initiation (GO:0045948)6.19647588
11regulation of protein glycosylation (GO:0060049)6.13549548
12translational termination (GO:0006415)5.85700046
13megakaryocyte development (GO:0035855)5.70375692
14regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 5.62413135
15activated T cell proliferation (GO:0050798)5.35029250
16positive regulation of signal transduction by p53 class mediator (GO:1901798)5.28771974
17negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)5.26650541
18positive regulation of glycoprotein biosynthetic process (GO:0010560)5.02768509
19cotranslational protein targeting to membrane (GO:0006613)4.87924681
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.87068244
21regulation of mitochondrial translation (GO:0070129)4.86968942
22protein targeting to ER (GO:0045047)4.74273000
23negative regulation of inclusion body assembly (GO:0090084)4.59133198
24secretory granule organization (GO:0033363)4.58075854
25translational elongation (GO:0006414)4.57083257
26leukocyte migration involved in inflammatory response (GO:0002523)4.53906926
27regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)4.48776969
28establishment of protein localization to endoplasmic reticulum (GO:0072599)4.45917325
29protein localization to endoplasmic reticulum (GO:0070972)4.45826948
30cellular protein complex disassembly (GO:0043624)4.34000886
31ubiquinone biosynthetic process (GO:0006744)4.24536445
32negative regulation of signal transduction by p53 class mediator (GO:1901797)4.24055898
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.20877274
34negative regulation of blood vessel endothelial cell migration (GO:0043537)4.01814287
35morphogenesis of an endothelium (GO:0003159)3.99186550
36endothelial tube morphogenesis (GO:0061154)3.99186550
37protein complex biogenesis (GO:0070271)3.98631245
38viral life cycle (GO:0019058)3.96142982
39translational initiation (GO:0006413)3.84870108
40diacylglycerol metabolic process (GO:0046339)3.83433364
41ubiquinone metabolic process (GO:0006743)3.79113798
42positive regulation of glycoprotein metabolic process (GO:1903020)3.71764688
43auditory behavior (GO:0031223)3.66547278
44erythrocyte maturation (GO:0043249)3.57570286
45negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.57460988
46protein polyglutamylation (GO:0018095)3.57036639
47quinone biosynthetic process (GO:1901663)3.56355921
48heme transport (GO:0015886)3.55328296
49protein complex disassembly (GO:0043241)3.46633880
50spermatid nucleus differentiation (GO:0007289)3.40221663
51negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.37314398
52cytochrome complex assembly (GO:0017004)3.36042607
53platelet formation (GO:0030220)3.35849364
54mechanosensory behavior (GO:0007638)3.34532225
55L-ascorbic acid metabolic process (GO:0019852)3.33512295
56mitochondrial respiratory chain complex assembly (GO:0033108)3.33084198
57macromolecular complex disassembly (GO:0032984)3.30016687
58nonmotile primary cilium assembly (GO:0035058)3.27586761
59transcytosis (GO:0045056)3.21628767
60leukocyte cell-cell adhesion (GO:0007159)3.19958411
61positive regulation of endothelial cell apoptotic process (GO:2000353)3.19904540
62lymphangiogenesis (GO:0001946)3.19468914
63regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)3.17963925
64piRNA metabolic process (GO:0034587)3.15638547
65dendritic spine morphogenesis (GO:0060997)3.15371045
66response to auditory stimulus (GO:0010996)3.12655394
67transcription from RNA polymerase I promoter (GO:0006360)3.11574064
68fusion of sperm to egg plasma membrane (GO:0007342)3.08560566
69protein targeting to membrane (GO:0006612)3.08297213
70pseudouridine synthesis (GO:0001522)3.07662641
71arachidonic acid secretion (GO:0050482)3.07635110
72icosanoid secretion (GO:0032309)3.07635110
73neurotransmitter-gated ion channel clustering (GO:0072578)3.07179187
74T cell apoptotic process (GO:0070231)3.05785966
75protein heterotetramerization (GO:0051290)3.03674888
76epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98515715
77negative regulation of endothelial cell migration (GO:0010596)2.95921122
78leukotriene biosynthetic process (GO:0019370)2.94101708
79synaptonemal complex assembly (GO:0007130)2.93258208
80negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)2.92720598
81negative regulation of translational initiation (GO:0045947)2.92256589
82neutrophil activation involved in immune response (GO:0002283)2.86765501
83response to nitrosative stress (GO:0051409)2.85521608
84pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.85231986
85negative regulation of chemokine production (GO:0032682)2.84850122
86heterotypic cell-cell adhesion (GO:0034113)2.83433911
87ncRNA 3-end processing (GO:0043628)2.81312550
88lymph vessel development (GO:0001945)2.78540711
89signal peptide processing (GO:0006465)2.78270060
90cellular anion homeostasis (GO:0030002)2.78066486
91necroptotic process (GO:0070266)2.74419230
92positive regulation of mast cell degranulation (GO:0043306)2.73372395
93positive regulation of mast cell activation involved in immune response (GO:0033008)2.73372395
94organic cation transport (GO:0015695)2.72485418
95translation (GO:0006412)2.71526786
96regulation of regulatory T cell differentiation (GO:0045589)2.71260614
97regulation of endothelial cell differentiation (GO:0045601)2.70176562
98negative regulation of membrane potential (GO:0045837)2.68367688
99iron coordination entity transport (GO:1901678)2.67269472
100neuronal stem cell maintenance (GO:0097150)2.65754919

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.25445558
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.50783565
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.57895413
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.08283660
5VDR_22108803_ChIP-Seq_LS180_Human2.82575403
6CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.58756873
7EZH2_22144423_ChIP-Seq_EOC_Human2.58533488
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.58003978
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.39758661
10RNF2_27304074_Chip-Seq_NSC_Mouse2.14644956
11PCGF2_27294783_Chip-Seq_NPCs_Mouse2.14302393
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.13705178
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.11289438
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05566468
15CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03969761
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01355829
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.94295796
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.94238242
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.94238242
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.94238242
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86772401
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85812389
23CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.80060449
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.79127597
25PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.75634125
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.74795874
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.71612161
28EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.70287095
29SRY_22984422_ChIP-ChIP_TESTIS_Rat1.63685994
30GBX2_23144817_ChIP-Seq_PC3_Human1.62954176
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.61723180
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.54641195
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.52108321
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50618540
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48552459
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.46584611
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.46584611
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43731959
39TP53_16413492_ChIP-PET_HCT116_Human1.35306012
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35080477
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34692439
42TBX3_20139965_ChIP-Seq_ESCs_Mouse1.31609582
43AR_21572438_ChIP-Seq_LNCaP_Human1.30932316
44TBX3_20139965_ChIP-Seq_MESCs_Mouse1.30169488
45SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.28372399
46SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27905693
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26858462
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25863792
49TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.25406040
50EGR1_19032775_ChIP-ChIP_M12_Human1.25344018
51TCF4_18268006_ChIP-ChIP_LS174T_Human1.24827916
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.24014245
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23665408
54IRF1_19129219_ChIP-ChIP_H3396_Human1.23346054
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.22061869
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21769251
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20456874
58STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.20062533
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19528683
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18288265
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16237165
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.13320682
63RUNX_20019798_ChIP-Seq_JUKART_Human1.10669914
64NANOG_19829295_ChIP-Seq_ESCs_Human1.09373746
65SOX2_19829295_ChIP-Seq_ESCs_Human1.09373746
66NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07878720
67RUNX2_22187159_ChIP-Seq_PCA_Human1.07316849
68MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07070002
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05991258
70AHR_22903824_ChIP-Seq_MCF-7_Human1.05467160
71TAF2_19829295_ChIP-Seq_ESCs_Human1.05268685
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.04954360
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03603480
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03603480
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02182090
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.01098543
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.00989358
78EZH2_27294783_Chip-Seq_NPCs_Mouse0.99185744
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98680384
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96732174
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96413676
82TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95686296
83ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93637096
84TP53_18474530_ChIP-ChIP_U2OS_Human0.93491454
85TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93139556
86SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90655249
87ARNT_22903824_ChIP-Seq_MCF-7_Human0.89804088
88CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89406265
89IGF1R_20145208_ChIP-Seq_DFB_Human0.89275903
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84060957
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82399996
92RBPJ_21746931_ChIP-Seq_IB4_Human0.78687734
93PRDM14_20953172_ChIP-Seq_ESCs_Human0.77495892
94FUS_26573619_Chip-Seq_HEK293_Human0.77022739
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.76886115
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.76754371
97RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.76049637
98MYC_18940864_ChIP-ChIP_HL60_Human0.76045182
99ZNF274_21170338_ChIP-Seq_K562_Hela0.74788642
100CBX2_22325352_ChIP-Seq_293T-Rex_Human0.74581720

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.28960129
2MP0009379_abnormal_foot_pigmentation4.87593086
3MP0006292_abnormal_olfactory_placode3.71607660
4MP0004147_increased_porphyrin_level3.66489049
5MP0001851_eye_inflammation2.73483821
6MP0005084_abnormal_gallbladder_morpholo2.64885311
7MP0003136_yellow_coat_color2.46437694
8MP0002933_joint_inflammation2.34171464
9MP0010386_abnormal_urinary_bladder2.11252482
10MP0002277_abnormal_respiratory_mucosa2.09125984
11MP0001879_abnormal_lymphatic_vessel2.06800178
12MP0002735_abnormal_chemical_nociception1.91401794
13MP0003724_increased_susceptibility_to1.84933654
14MP0004145_abnormal_muscle_electrophysio1.84369240
15MP0005410_abnormal_fertilization1.81449031
16MP0003195_calcinosis1.79191069
17MP0001986_abnormal_taste_sensitivity1.79154508
18MP0004142_abnormal_muscle_tone1.75777327
19MP0001529_abnormal_vocalization1.74072202
20MP0000372_irregular_coat_pigmentation1.57695352
21MP0002148_abnormal_hypersensitivity_rea1.55309489
22MP0008961_abnormal_basal_metabolism1.53025976
23MP0001905_abnormal_dopamine_level1.48551966
24MP0002938_white_spotting1.45520822
25MP0004885_abnormal_endolymph1.45175409
26MP0002653_abnormal_ependyma_morphology1.44199732
27MP0005253_abnormal_eye_physiology1.38621081
28MP0003638_abnormal_response/metabolism_1.38235754
29MP0003880_abnormal_central_pattern1.37999304
30MP0005367_renal/urinary_system_phenotyp1.34963099
31MP0000516_abnormal_urinary_system1.34963099
32MP0000462_abnormal_digestive_system1.28897146
33MP0000534_abnormal_ureter_morphology1.27933061
34MP0003011_delayed_dark_adaptation1.27520345
35MP0001486_abnormal_startle_reflex1.27255908
36MP0008260_abnormal_autophagy1.26562914
37MP0009053_abnormal_anal_canal1.26274713
38MP0008875_abnormal_xenobiotic_pharmacok1.21178070
39MP0006276_abnormal_autonomic_nervous1.20316940
40MP0001968_abnormal_touch/_nociception1.19396450
41MP0003315_abnormal_perineum_morphology1.18826893
42MP0001664_abnormal_digestion1.17366414
43MP0002837_dystrophic_cardiac_calcinosis1.15806097
44MP0005197_abnormal_uvea_morphology1.14959797
45MP0008789_abnormal_olfactory_epithelium1.14834007
46MP0009250_abnormal_appendicular_skeleto1.13471883
47MP0006082_CNS_inflammation1.12858228
48MP0005167_abnormal_blood-brain_barrier1.12573924
49MP0002736_abnormal_nociception_after1.09633906
50MP0005408_hypopigmentation1.09038568
51MP0009745_abnormal_behavioral_response1.08490875
52MP0003943_abnormal_hepatobiliary_system1.06438952
53MP0000537_abnormal_urethra_morphology1.04853739
54MP0001440_abnormal_grooming_behavior1.04701365
55MP0000343_altered_response_to1.04594199
56MP0001727_abnormal_embryo_implantation1.03070404
57MP0009046_muscle_twitch1.02031914
58MP0005386_behavior/neurological_phenoty0.97942583
59MP0004924_abnormal_behavior0.97942583
60MP0002928_abnormal_bile_duct0.96159152
61MP0000778_abnormal_nervous_system0.95908191
62MP0008004_abnormal_stomach_pH0.95579678
63MP0005195_abnormal_posterior_eye0.93532631
64MP0005085_abnormal_gallbladder_physiolo0.93255429
65MP0005595_abnormal_vascular_smooth0.92819634
66MP0000230_abnormal_systemic_arterial0.91451827
67MP0005025_abnormal_response_to0.91412669
68MP0006035_abnormal_mitochondrial_morpho0.90785601
69MP0000538_abnormal_urinary_bladder0.90769138
70MP0003937_abnormal_limbs/digits/tail_de0.90550064
71MP0001485_abnormal_pinna_reflex0.90542365
72MP0005503_abnormal_tendon_morphology0.90415687
73MP0002876_abnormal_thyroid_physiology0.89604918
74MP0002557_abnormal_social/conspecific_i0.88103586
75MP0002572_abnormal_emotion/affect_behav0.87586123
76MP0005000_abnormal_immune_tolerance0.87505340
77MP0002067_abnormal_sensory_capabilities0.86606760
78MP0001800_abnormal_humoral_immune0.84632863
79MP0001191_abnormal_skin_condition0.83796029
80MP0005636_abnormal_mineral_homeostasis0.83685998
81MP0002272_abnormal_nervous_system0.81398351
82MP0005409_darkened_coat_color0.80673211
83MP0002064_seizures0.79563380
84MP0005423_abnormal_somatic_nervous0.78508562
85MP0002184_abnormal_innervation0.76610632
86MP0005645_abnormal_hypothalamus_physiol0.76184729
87MP0002733_abnormal_thermal_nociception0.75515034
88MP0008872_abnormal_physiological_respon0.75143673
89MP0005551_abnormal_eye_electrophysiolog0.74961473
90MP0000631_abnormal_neuroendocrine_gland0.74889943
91MP0001293_anophthalmia0.74063390
92MP0008058_abnormal_DNA_repair0.74035521
93MP0003137_abnormal_impulse_conducting0.72998132
94MP0002723_abnormal_immune_serum0.72680009
95MP0000049_abnormal_middle_ear0.72504020
96MP0006072_abnormal_retinal_apoptosis0.71970408
97MP0005391_vision/eye_phenotype0.69930644
98MP0009785_altered_susceptibility_to0.68180575
99MP0002419_abnormal_innate_immunity0.67248540
100MP0001970_abnormal_pain_threshold0.65928692

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)6.58410135
2Congenital, generalized hypertrichosis (HP:0004540)4.70689133
3Periodontitis (HP:0000704)4.31093316
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.12898477
5Aplastic anemia (HP:0001915)3.83306369
6Abnormality of binocular vision (HP:0011514)3.82223917
7Diplopia (HP:0000651)3.82223917
8Aplasia/Hypoplasia of the sacrum (HP:0008517)3.58474881
9Chronic bronchitis (HP:0004469)3.44812279
10Abnormality of the intervertebral disk (HP:0005108)3.42821617
11Nasal speech (HP:0001611)3.33064580
12Leukocytosis (HP:0001974)3.29468634
13Reticulocytopenia (HP:0001896)3.22005359
14Sparse scalp hair (HP:0002209)3.21570532
15Concave nail (HP:0001598)3.19622367
16Maternal diabetes (HP:0009800)3.17261018
17Recurrent abscess formation (HP:0002722)3.07807570
18Cortical visual impairment (HP:0100704)3.00482319
19Status epilepticus (HP:0002133)2.91511997
20Aplasia/Hypoplasia of the spleen (HP:0010451)2.88983777
21Hypoplastic toenails (HP:0001800)2.78774349
22Asplenia (HP:0001746)2.78765073
23Autoimmune thrombocytopenia (HP:0001973)2.76322565
24Absent eyebrow (HP:0002223)2.74968519
25Macrocytic anemia (HP:0001972)2.70584595
26Anencephaly (HP:0002323)2.70375929
27Acute necrotizing encephalopathy (HP:0006965)2.68885997
28Delayed CNS myelination (HP:0002188)2.67163787
29Papilledema (HP:0001085)2.66857721
30Abnormal respiratory motile cilium physiology (HP:0012261)2.65467926
31Abnormality of macular pigmentation (HP:0008002)2.64656864
32Hypotrichosis (HP:0001006)2.61323864
33Hemiparesis (HP:0001269)2.60362943
34Congenital stationary night blindness (HP:0007642)2.58558333
35Unsteady gait (HP:0002317)2.56998646
36Gingivitis (HP:0000230)2.56233728
37Pancreatic cysts (HP:0001737)2.53982549
38Hypoplasia of the uterus (HP:0000013)2.50838968
39Pancreatic fibrosis (HP:0100732)2.42878487
40Absent eyelashes (HP:0000561)2.40334001
41Cerebral hypomyelination (HP:0006808)2.36869594
42Aplasia/hypoplasia of the uterus (HP:0008684)2.34891738
43Bony spicule pigmentary retinopathy (HP:0007737)2.34859262
44Abnormal mitochondria in muscle tissue (HP:0008316)2.30079496
45Cerebellar dysplasia (HP:0007033)2.28440583
46Abolished electroretinogram (ERG) (HP:0000550)2.24467902
47Woolly hair (HP:0002224)2.24345873
48Pallor (HP:0000980)2.23009120
49Confusion (HP:0001289)2.22677633
50Dyskinesia (HP:0100660)2.19413465
51True hermaphroditism (HP:0010459)2.17753913
52Progressive macrocephaly (HP:0004481)2.16776063
53Acute encephalopathy (HP:0006846)2.16484095
54Supernumerary spleens (HP:0009799)2.15897342
553-Methylglutaconic aciduria (HP:0003535)2.14166745
56Pendular nystagmus (HP:0012043)2.13680841
57Pulmonic stenosis (HP:0001642)2.13087754
58Hypoplasia of the fovea (HP:0007750)2.09059963
59Aplasia/Hypoplasia of the fovea (HP:0008060)2.09059963
60Autoimmune hemolytic anemia (HP:0001890)2.06571809
61Atonic seizures (HP:0010819)2.06361948
62Aplasia of the musculature (HP:0100854)2.06010962
63Abnormality of reticulocytes (HP:0004312)2.02429389
64Septo-optic dysplasia (HP:0100842)2.02224364
65Hypoproteinemia (HP:0003075)1.99227979
66Rhinitis (HP:0012384)1.97352195
67Attenuation of retinal blood vessels (HP:0007843)1.95208654
68Absent hand (HP:0004050)1.92003931
69Hyperglycinemia (HP:0002154)1.91517377
70Increased IgM level (HP:0003496)1.89812720
7111 pairs of ribs (HP:0000878)1.89555767
72Abnormality of cells of the erythroid lineage (HP:0012130)1.87094940
73Abnormal delayed hypersensitivity skin test (HP:0002963)1.86274177
74Mitochondrial inheritance (HP:0001427)1.84876105
75Focal seizures (HP:0007359)1.84081031
76Paralysis (HP:0003470)1.83692280
77Agitation (HP:0000713)1.83127724
78Alveolar cell carcinoma (HP:0006519)1.82441049
79Morphological abnormality of the pyramidal tract (HP:0002062)1.81093367
80Deep philtrum (HP:0002002)1.80202330
81Oral leukoplakia (HP:0002745)1.78767149
82Aplasia/Hypoplasia of the tibia (HP:0005772)1.77896404
83Rimmed vacuoles (HP:0003805)1.76312277
84Absent hair (HP:0002298)1.76123244
85Abnormal number of erythroid precursors (HP:0012131)1.75143039
86B lymphocytopenia (HP:0010976)1.74896674
87Elevated erythrocyte sedimentation rate (HP:0003565)1.74125061
88Scotoma (HP:0000575)1.73420159
89Short femoral neck (HP:0100864)1.72907038
90Absence seizures (HP:0002121)1.72531057
91Abnormality of the fovea (HP:0000493)1.71974058
92Male pseudohermaphroditism (HP:0000037)1.71168386
93Absent septum pellucidum (HP:0001331)1.67492943
94Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.66655348
95Myelomeningocele (HP:0002475)1.66636072
96Ulnar claw (HP:0001178)1.65693352
97Increased CSF lactate (HP:0002490)1.64503942
98Cupped ribs (HP:0000887)1.64446534
99Cystic liver disease (HP:0006706)1.63566132
100Abnormality of B cell number (HP:0010975)1.63562188

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK18.93193521
2TIE15.12446109
3TSSK64.87649289
4MAPK153.58907765
5MAP4K13.24585263
6PBK3.11557416
7BMPR23.01740444
8PRKCH2.71077584
9EPHB22.24206027
10PRKCI2.18797972
11TYRO32.18763222
12TXK1.80791542
13FES1.70502594
14PRKCG1.53875292
15PASK1.47148345
16PNCK1.37624919
17PDPK11.32013228
18CSK1.30418410
19VRK11.20024291
20DAPK31.13288036
21PRKCD1.03578500
22PIK3CA1.02466319
23GRK10.97858197
24STK38L0.94132661
25WNK30.93313084
26PDK20.91220102
27FRK0.89345442
28OXSR10.89154859
29PRKCQ0.88542286
30STK390.87825733
31NEK10.87102999
32DAPK10.87033035
33PRKCE0.86594135
34CDK30.85486552
35EPHA40.82054613
36INSRR0.80586248
37DYRK20.79002683
38WEE10.75151770
39FGR0.72597672
40RPS6KA50.72509268
41TAOK30.68758951
42LCK0.66973586
43ADRBK10.65267159
44CCNB10.58847747
45DYRK30.58161112
46MAPK130.54094836
47MAP3K90.53960988
48MAP4K20.53815464
49BMPR1B0.52630856
50MAPK40.52086053
51EPHB10.50046897
52UHMK10.49556810
53NTRK30.45557330
54WNK40.45553859
55CAMK10.45420740
56EPHA30.43681861
57MAP3K20.43169349
58VRK20.42330460
59PRKCB0.41351475
60STK240.41198918
61CAMK2A0.40803000
62ADRBK20.39208924
63IRAK20.39182800
64OBSCN0.38216503
65DAPK20.37759870
66ICK0.37576246
67FLT30.37417334
68MAP2K60.37286989
69GRK70.37156092
70GSK3A0.37037127
71CAMK2G0.37023647
72PRKCZ0.36895843
73MATK0.34611391
74TEC0.33174936
75LATS20.33049937
76PKN10.32576778
77SRC0.31962905
78PRKACA0.30230827
79CDK80.29315230
80PIK3CG0.28672410
81SIK20.28503141
82CSNK2A20.28026867
83MARK10.27772705
84CAMK2D0.26108647
85ERBB20.25998483
86CSNK2A10.23598363
87DYRK1B0.23443958
88PRKCA0.22690380
89PRKD10.20313821
90IKBKB0.20180954
91RPS6KA60.19961447
92EGFR0.19225538
93NTRK20.19207189
94CASK0.19167075
95NTRK10.17901225
96FYN0.17779603
97CSNK1A10.17111341
98STK380.16967914
99EIF2AK30.16563154
100MAP2K20.15941367

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.02325416
2RNA polymerase_Homo sapiens_hsa030203.29120947
3Graft-versus-host disease_Homo sapiens_hsa053322.79860388
4Tyrosine metabolism_Homo sapiens_hsa003502.77936034
5Malaria_Homo sapiens_hsa051442.69142394
6Legionellosis_Homo sapiens_hsa051342.22367500
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.21716217
8Oxidative phosphorylation_Homo sapiens_hsa001902.08516371
9Staphylococcus aureus infection_Homo sapiens_hsa051502.04873838
10Allograft rejection_Homo sapiens_hsa053302.04466371
11Parkinsons disease_Homo sapiens_hsa050122.04443093
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.00722476
13Autoimmune thyroid disease_Homo sapiens_hsa053201.99447499
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.89280880
15Type I diabetes mellitus_Homo sapiens_hsa049401.86738987
16Olfactory transduction_Homo sapiens_hsa047401.85114231
17Prion diseases_Homo sapiens_hsa050201.72257764
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.70799078
19Viral myocarditis_Homo sapiens_hsa054161.69966877
20African trypanosomiasis_Homo sapiens_hsa051431.67993795
21Rheumatoid arthritis_Homo sapiens_hsa053231.67821190
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64551808
23Dorso-ventral axis formation_Homo sapiens_hsa043201.64249407
24Cardiac muscle contraction_Homo sapiens_hsa042601.63450646
25Sulfur relay system_Homo sapiens_hsa041221.57337043
26Glycerolipid metabolism_Homo sapiens_hsa005611.43050765
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42978269
28Linoleic acid metabolism_Homo sapiens_hsa005911.41037795
29Antigen processing and presentation_Homo sapiens_hsa046121.38021271
30Choline metabolism in cancer_Homo sapiens_hsa052311.36055064
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34394423
32Alzheimers disease_Homo sapiens_hsa050101.34347034
33Phototransduction_Homo sapiens_hsa047441.30891303
34Leishmaniasis_Homo sapiens_hsa051401.29933319
35ErbB signaling pathway_Homo sapiens_hsa040121.26632770
36Pertussis_Homo sapiens_hsa051331.18168036
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.13543730
38Huntingtons disease_Homo sapiens_hsa050161.12439311
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10458001
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10144431
41Protein export_Homo sapiens_hsa030601.06730265
42Complement and coagulation cascades_Homo sapiens_hsa046101.05356021
43RNA degradation_Homo sapiens_hsa030181.03797075
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99949752
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95305298
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93736543
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91634128
48Nicotine addiction_Homo sapiens_hsa050330.90705831
49Fat digestion and absorption_Homo sapiens_hsa049750.90559848
50Chemical carcinogenesis_Homo sapiens_hsa052040.86824809
51Asthma_Homo sapiens_hsa053100.85888054
52Bile secretion_Homo sapiens_hsa049760.77867833
53Mineral absorption_Homo sapiens_hsa049780.76645118
54Nitrogen metabolism_Homo sapiens_hsa009100.76572046
55Caffeine metabolism_Homo sapiens_hsa002320.75327382
56Ether lipid metabolism_Homo sapiens_hsa005650.73705971
57Purine metabolism_Homo sapiens_hsa002300.73061950
58Pyrimidine metabolism_Homo sapiens_hsa002400.70732746
59Glutathione metabolism_Homo sapiens_hsa004800.68996418
60Insulin resistance_Homo sapiens_hsa049310.63026309
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61419538
62TGF-beta signaling pathway_Homo sapiens_hsa043500.60322791
63Acute myeloid leukemia_Homo sapiens_hsa052210.59412353
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.57058767
65HIF-1 signaling pathway_Homo sapiens_hsa040660.56747424
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.55417269
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54002188
68Butanoate metabolism_Homo sapiens_hsa006500.53366297
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.51369191
70Taste transduction_Homo sapiens_hsa047420.51321518
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.50001477
72Arachidonic acid metabolism_Homo sapiens_hsa005900.48905466
73Tryptophan metabolism_Homo sapiens_hsa003800.48072596
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46004217
75Measles_Homo sapiens_hsa051620.45742956
76Serotonergic synapse_Homo sapiens_hsa047260.45325209
77Insulin secretion_Homo sapiens_hsa049110.43639799
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42389462
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42238674
80T cell receptor signaling pathway_Homo sapiens_hsa046600.41424105
81Protein digestion and absorption_Homo sapiens_hsa049740.40413988
82Calcium signaling pathway_Homo sapiens_hsa040200.35316508
83Rap1 signaling pathway_Homo sapiens_hsa040150.34991519
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34952979
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34020508
86Axon guidance_Homo sapiens_hsa043600.33959585
87Hematopoietic cell lineage_Homo sapiens_hsa046400.33065356
88ABC transporters_Homo sapiens_hsa020100.32344419
89Ras signaling pathway_Homo sapiens_hsa040140.30738185
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.30671592
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30035333
92Retinol metabolism_Homo sapiens_hsa008300.28957620
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28896730
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.26786104
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24510037
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.24409773
97Circadian entrainment_Homo sapiens_hsa047130.23767561
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.23493906
99Amoebiasis_Homo sapiens_hsa051460.23167395
100Morphine addiction_Homo sapiens_hsa050320.21722645

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