RAC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.36668179
2transcription from mitochondrial promoter (GO:0006390)6.17585705
3proline metabolic process (GO:0006560)6.02757830
4establishment or maintenance of monopolar cell polarity (GO:0061339)5.85210956
5establishment of monopolar cell polarity (GO:0061162)5.85210956
6embryonic process involved in female pregnancy (GO:0060136)5.82352619
7establishment of apical/basal cell polarity (GO:0035089)5.77670402
8positive regulation of protein homooligomerization (GO:0032464)5.69304100
9replication fork processing (GO:0031297)5.53846230
10establishment of mitochondrion localization, microtubule-mediated (GO:0034643)5.34385843
11mitochondrion transport along microtubule (GO:0047497)5.34385843
12DNA unwinding involved in DNA replication (GO:0006268)5.27171778
13cell migration in hindbrain (GO:0021535)5.26487424
14regulation of protein homooligomerization (GO:0032462)5.24972762
15pyrimidine nucleobase catabolic process (GO:0006208)5.16684548
16negative regulation of JAK-STAT cascade (GO:0046426)5.13742407
17heterochromatin organization (GO:0070828)5.04669730
18oxidative demethylation (GO:0070989)5.03259706
19regulation of cAMP-dependent protein kinase activity (GO:2000479)4.85316019
20regulation of integrin activation (GO:0033623)4.82577829
21establishment of mitochondrion localization (GO:0051654)4.75445880
22negative regulation of Ras GTPase activity (GO:0034261)4.37171132
23DNA deamination (GO:0045006)4.36481663
24L-serine metabolic process (GO:0006563)4.29101518
25maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.26365425
26peptidyl-arginine methylation (GO:0018216)4.08781834
27peptidyl-arginine N-methylation (GO:0035246)4.08781834
28mitochondrial DNA metabolic process (GO:0032042)4.07657710
29synaptic vesicle endocytosis (GO:0048488)4.01844271
30nucleobase catabolic process (GO:0046113)3.98573408
31regulation of mammary gland epithelial cell proliferation (GO:0033599)3.98408165
32nucleosome disassembly (GO:0006337)3.97513564
33protein-DNA complex disassembly (GO:0032986)3.97513564
34DNA strand renaturation (GO:0000733)3.83099863
35DNA replication initiation (GO:0006270)3.81668766
36ribosomal small subunit biogenesis (GO:0042274)3.81668570
37layer formation in cerebral cortex (GO:0021819)3.80036656
38DNA strand elongation involved in DNA replication (GO:0006271)3.77079928
39protein complex localization (GO:0031503)3.76783534
40mitotic G1 DNA damage checkpoint (GO:0031571)3.73488000
41nuclear pore complex assembly (GO:0051292)3.69489519
42positive regulation of dendritic spine morphogenesis (GO:0061003)3.68106611
43negative regulation of protein oligomerization (GO:0032460)3.66996985
44DNA strand elongation (GO:0022616)3.64927970
45mitotic chromosome condensation (GO:0007076)3.62632338
46somatic diversification of immune receptors via somatic mutation (GO:0002566)3.62097451
47somatic hypermutation of immunoglobulin genes (GO:0016446)3.62097451
48regulation of early endosome to late endosome transport (GO:2000641)3.61956884
49chromatin assembly (GO:0031497)3.59047237
50regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.58327506
51respiratory system process (GO:0003016)3.46587025
52spliceosomal tri-snRNP complex assembly (GO:0000244)3.45904409
53poly(A)+ mRNA export from nucleus (GO:0016973)3.44425054
54viral mRNA export from host cell nucleus (GO:0046784)3.43434003
55cellular response to ATP (GO:0071318)3.43337604
56positive regulation of microtubule polymerization (GO:0031116)3.42346290
57glial cell migration (GO:0008347)3.38955798
58nuclear pore organization (GO:0006999)3.37120597
59formation of translation preinitiation complex (GO:0001731)3.36732325
60DNA replication checkpoint (GO:0000076)3.36205534
61embryonic placenta development (GO:0001892)3.31846054
62regulation of translational fidelity (GO:0006450)3.29003590
63response to pheromone (GO:0019236)3.25196371
64regulation of protein oligomerization (GO:0032459)3.25145560
65G1 DNA damage checkpoint (GO:0044783)3.24421496
66histone H4-K12 acetylation (GO:0043983)3.23895728
67mitotic G1/S transition checkpoint (GO:0044819)3.23750267
68establishment of integrated proviral latency (GO:0075713)3.23688314
69establishment of protein localization to mitochondrial membrane (GO:0090151)3.22481615
70DNA integration (GO:0015074)3.19433101
71convergent extension (GO:0060026)3.17766249
72histone arginine methylation (GO:0034969)3.17540873
73neuromuscular process controlling posture (GO:0050884)3.16220519
74negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.15877364
75positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.15805275
76negative regulation of cell cycle arrest (GO:0071157)3.15522216
77embryonic camera-type eye development (GO:0031076)3.15127250
78mitotic sister chromatid segregation (GO:0000070)3.14610669
79central nervous system projection neuron axonogenesis (GO:0021952)3.12826441
80planar cell polarity pathway involved in neural tube closure (GO:0090179)3.12312476
81mRNA cleavage (GO:0006379)3.12309937
82protein localization to chromosome, centromeric region (GO:0071459)3.12111227
83negative regulation of mRNA processing (GO:0050686)3.11797199
84positive regulation of protein oligomerization (GO:0032461)3.10188887
85regulation of respiratory system process (GO:0044065)3.09985456
86synaptic vesicle exocytosis (GO:0016079)3.09967962
87positive regulation of microtubule polymerization or depolymerization (GO:0031112)3.08245376
88dosage compensation (GO:0007549)3.07820708
89glutamine family amino acid biosynthetic process (GO:0009084)3.06735606
90nodal signaling pathway (GO:0038092)3.06051292
91signal complex assembly (GO:0007172)3.05829660
92N-glycan processing (GO:0006491)3.05607011
93telomere maintenance via semi-conservative replication (GO:0032201)3.04319232
94regulation of microtubule polymerization (GO:0031113)3.03945663
95viral transcription (GO:0019083)3.01685458
96rRNA transcription (GO:0009303)3.01547719
97maturation of SSU-rRNA (GO:0030490)2.98484845
98negative regulation of microtubule polymerization (GO:0031115)2.98046205
99peptidyl-arginine omega-N-methylation (GO:0035247)2.96989258
100negative regulation of RNA splicing (GO:0033119)2.96161479
101intracellular estrogen receptor signaling pathway (GO:0030520)2.95969893
102polarized epithelial cell differentiation (GO:0030859)2.94955462
103protein localization to kinetochore (GO:0034501)2.93369513
104regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.92327121
105positive regulation of developmental pigmentation (GO:0048087)2.91554160
106cellular protein complex localization (GO:0034629)2.91087478
107pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.90945421
108base-excision repair, AP site formation (GO:0006285)2.90079341
109labyrinthine layer development (GO:0060711)2.89449416
110pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.88558401
111negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.87990917
112negative regulation of mRNA metabolic process (GO:1903312)2.87164132
113apoptotic process involved in morphogenesis (GO:0060561)2.87137416
114translational termination (GO:0006415)2.85936541
115pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.85799067
116serine family amino acid biosynthetic process (GO:0009070)2.85643917
117negative regulation of heart rate (GO:0010459)2.85353550
118sister chromatid segregation (GO:0000819)2.85143870
119anatomical structure regression (GO:0060033)2.83339551
120regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.83028193
121regulation of sister chromatid cohesion (GO:0007063)2.81586581
122regulation of hippo signaling (GO:0035330)2.81372488
123locomotory exploration behavior (GO:0035641)2.81325262
124nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.81047034
125positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.81007675
126regulation of translational elongation (GO:0006448)2.80336821
127pore complex assembly (GO:0046931)2.78655408
128protein retention in ER lumen (GO:0006621)2.78303805
129ribonucleoprotein complex biogenesis (GO:0022613)2.78193951
130base-excision repair (GO:0006284)2.77848826
131regulation of mitochondrial depolarization (GO:0051900)2.76574630
132regulation of RNA export from nucleus (GO:0046831)2.76051243
133spinal cord development (GO:0021510)2.75623601
134DNA duplex unwinding (GO:0032508)2.75275801
135regulation of glomerular filtration (GO:0003093)2.75030972
136establishment of protein localization to vacuole (GO:0072666)2.74621967
137protein targeting to vacuole (GO:0006623)2.74621967
138protein targeting to lysosome (GO:0006622)2.74621967
139non-recombinational repair (GO:0000726)2.74065653
140double-strand break repair via nonhomologous end joining (GO:0006303)2.74065653
141dendrite morphogenesis (GO:0048813)2.73598757
142synaptic vesicle maturation (GO:0016188)2.72943730
143nucleobase-containing small molecule interconversion (GO:0015949)2.71830208
144nuclear envelope reassembly (GO:0031468)2.71424128
145mitotic nuclear envelope reassembly (GO:0007084)2.71424128
146ribosomal small subunit assembly (GO:0000028)2.71203465
147UTP biosynthetic process (GO:0006228)2.71182497
148face development (GO:0060324)2.69918144
149regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.65538274
150translational elongation (GO:0006414)2.65399090
151pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.65219986
152regulation of NFAT protein import into nucleus (GO:0051532)2.64714187
153RNA stabilization (GO:0043489)2.63601121
154mRNA stabilization (GO:0048255)2.63601121
155ribosome biogenesis (GO:0042254)2.63134571
156pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.60578172
157regulation of translational termination (GO:0006449)2.60381066
158DNA topological change (GO:0006265)2.60192940
159paraxial mesoderm development (GO:0048339)2.59207681
160DNA geometric change (GO:0032392)2.59010978
161maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.57273646
162chromosome condensation (GO:0030261)2.57106545
163mitotic nuclear envelope disassembly (GO:0007077)2.56013375
164regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.55499778
165chromatin assembly or disassembly (GO:0006333)2.54626688
166protein complex disassembly (GO:0043241)2.54219022
167folic acid-containing compound biosynthetic process (GO:0009396)2.51848508
168IMP biosynthetic process (GO:0006188)2.49508148
169CTP biosynthetic process (GO:0006241)2.46231396
170CTP metabolic process (GO:0046036)2.46231396
171DNA replication-dependent nucleosome organization (GO:0034723)2.46219319
172DNA replication-dependent nucleosome assembly (GO:0006335)2.46219319
173ribosomal large subunit biogenesis (GO:0042273)2.45953508
174DNA conformation change (GO:0071103)2.45698252
175pre-miRNA processing (GO:0031054)2.45329117
176membrane disassembly (GO:0030397)2.42302934
177nuclear envelope disassembly (GO:0051081)2.42302934
178positive regulation of chromosome segregation (GO:0051984)2.41959007
179guanosine-containing compound biosynthetic process (GO:1901070)2.41369204
180protein maturation by protein folding (GO:0022417)2.40412312
181outer ear morphogenesis (GO:0042473)2.40034756
182positive regulation of DNA-dependent DNA replication (GO:2000105)2.39421304
183macromolecular complex disassembly (GO:0032984)2.38191185
184UTP metabolic process (GO:0046051)2.37681045

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.76109635
2ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.79753551
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.35654823
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.33307667
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.23416539
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.19043194
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.99795760
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.91194695
9ERG_21242973_ChIP-ChIP_JURKAT_Human2.72555706
10SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.69049482
11ZFP281_18757296_ChIP-ChIP_E14_Mouse2.62359878
12NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.61981703
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.61172270
14XRN2_22483619_ChIP-Seq_HELA_Human2.60525315
15SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.59892896
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.58139850
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.50517214
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.50517214
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.50517214
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39214284
21LXR_22292898_ChIP-Seq_THP-1_Human2.29390984
22* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.28960039
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.22554020
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21321767
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20076160
26ZNF263_19887448_ChIP-Seq_K562_Human2.18589848
27POU5F1_16518401_ChIP-PET_MESCs_Mouse2.18575712
28ZFP281_27345836_Chip-Seq_ESCs_Mouse2.09703632
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.03430991
30* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.98317199
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.97661864
32NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.96473002
33RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.95432347
34TCF3_18692474_ChIP-Seq_MESCs_Mouse1.90754124
35CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.90085271
36ZFX_18555785_ChIP-Seq_MESCs_Mouse1.86232411
37NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.83849621
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83246627
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.82625051
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.81685190
41* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78759053
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78669466
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77591667
44* KDM2B_26808549_Chip-Seq_K562_Human1.77298925
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73533358
46NANOG_21062744_ChIP-ChIP_HESCs_Human1.71264925
47TTF2_22483619_ChIP-Seq_HELA_Human1.70135822
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65953554
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.60200604
50KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.59863460
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.59771832
52TCF3_18692474_ChIP-Seq_MEFs_Mouse1.58267997
53* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.57153325
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56927923
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56622230
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.56460522
57REST_21632747_ChIP-Seq_MESCs_Mouse1.55669678
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52156784
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.52030814
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.51504651
61* KDM2B_26808549_Chip-Seq_DND41_Human1.51384125
62* VDR_21846776_ChIP-Seq_THP-1_Human1.49203686
63TP53_20018659_ChIP-ChIP_R1E_Mouse1.48946994
64GABP_19822575_ChIP-Seq_HepG2_Human1.46758475
65* RING1B_27294783_Chip-Seq_NPCs_Mouse1.46653281
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.46082345
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.46081132
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45763046
69CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.44021293
70DCP1A_22483619_ChIP-Seq_HELA_Human1.41852986
71RACK7_27058665_Chip-Seq_MCF-7_Human1.41560835
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41165773
73PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.39905902
74* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.38263611
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36932268
76* TET1_21490601_ChIP-Seq_MESCs_Mouse1.36163849
77CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35384780
78PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34706925
79POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.34358351
80SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.33992895
81KDM5A_27292631_Chip-Seq_BREAST_Human1.33141185
82* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33051524
83CTCF_27219007_Chip-Seq_Bcells_Human1.32825123
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32442180
85P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30534733
86TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.28963233
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27558306
88EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26341721
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.25992987
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.25973851
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24495312
92NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.23135940
93EZH2_22144423_ChIP-Seq_EOC_Human1.22950926
94RARB_27405468_Chip-Seq_BRAIN_Mouse1.21670060
95NANOG_18692474_ChIP-Seq_MESCs_Mouse1.21627517
96KDM2B_26808549_Chip-Seq_JURKAT_Human1.21505342
97STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21405153
98SOX2_18692474_ChIP-Seq_MESCs_Mouse1.21297016
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21241905
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20723072
101MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20472361
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20157048
103* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19563323
104CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18531108
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16140665
106OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15991394
107* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15330108
108PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15052438
109* FOXP1_21924763_ChIP-Seq_HESCs_Human1.14623968
110SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14005814
111CREB1_26743006_Chip-Seq_LNCaP_Human1.11748922
112POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11051175
113RING1B_27294783_Chip-Seq_ESCs_Mouse1.10448217
114NANOG_16518401_ChIP-PET_MESCs_Mouse1.10428934
115MYC_22102868_ChIP-Seq_BL_Human1.10381249
116POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10333733
117SMC4_20622854_ChIP-Seq_HELA_Human1.09511216
118NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09230423
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05965926
120SOX2_18692474_ChIP-Seq_MEFs_Mouse1.04988385
121KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04642083
122TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.04602481
123* AR_21909140_ChIP-Seq_LNCAP_Human1.04558961
124OCT4_19829295_ChIP-Seq_ESCs_Human1.04459320
125WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03871468
126NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03822086
127MYC_18555785_ChIP-Seq_MESCs_Mouse1.03800418
128ETS1_21867929_ChIP-Seq_TH2_Mouse1.03493821
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03097489
130* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02951180
131* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02516031
132CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02156112
133TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01585702
134* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01447991
135* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01427017
136E2F1_20622854_ChIP-Seq_HELA_Human1.01005607
137RARB_24833708_ChIP-Seq_LIVER_Mouse1.00047203
138SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00018248
139OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99860894
140E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98791530
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98458657
142SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98140547
143CIITA_25753668_ChIP-Seq_RAJI_Human0.97482348
144* TP53_23651856_ChIP-Seq_MEFs_Mouse0.97184989
145P68_20966046_ChIP-Seq_HELA_Human0.96881044
146SA1_27219007_Chip-Seq_ERYTHROID_Human0.96654213
147* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96576610
148SPI1_26923725_Chip-Seq_HPCs_Mouse0.96533371
149THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95974687
150TP63_19390658_ChIP-ChIP_HaCaT_Human0.95416012
151* ELK3_25401928_ChIP-Seq_HUVEC_Human0.94906284
152YY1_22570637_ChIP-Seq_MALME-3M_Human0.93820819
153ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93483819
154* NCOR1_26117541_ChIP-Seq_K562_Human0.93441855

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.47494921
2MP0004233_abnormal_muscle_weight3.43380964
3MP0008057_abnormal_DNA_replication3.35976264
4MP0003693_abnormal_embryo_hatching3.31204823
5MP0010030_abnormal_orbit_morphology3.30906421
6MP0009278_abnormal_bone_marrow3.25994130
7MP0005171_absent_coat_pigmentation3.24350881
8MP0003111_abnormal_nucleus_morphology3.20169879
9MP0000537_abnormal_urethra_morphology2.68077549
10MP0002653_abnormal_ependyma_morphology2.57873658
11MP0003283_abnormal_digestive_organ2.54665042
12MP0003119_abnormal_digestive_system2.54435325
13MP0000778_abnormal_nervous_system2.33403035
14MP0003890_abnormal_embryonic-extraembry2.29709523
15MP0004133_heterotaxia2.26952389
16MP0003077_abnormal_cell_cycle2.26276045
17MP0005623_abnormal_meninges_morphology2.24537396
18MP0001346_abnormal_lacrimal_gland2.21880821
19MP0003123_paternal_imprinting2.19444648
20MP0004185_abnormal_adipocyte_glucose2.19329278
21MP0008995_early_reproductive_senescence2.13407986
22MP0000678_abnormal_parathyroid_gland2.12619408
23MP0003705_abnormal_hypodermis_morpholog2.11481355
24MP0004270_analgesia1.99895776
25MP0001730_embryonic_growth_arrest1.95344879
26MP0006072_abnormal_retinal_apoptosis1.91853541
27MP0003635_abnormal_synaptic_transmissio1.91812818
28MP0002009_preneoplasia1.91671074
29MP0000579_abnormal_nail_morphology1.91256902
30* MP0002063_abnormal_learning/memory/cond1.89026210
31MP0009672_abnormal_birth_weight1.88518626
32MP0000955_abnormal_spinal_cord1.82441261
33MP0005645_abnormal_hypothalamus_physiol1.81030278
34MP0005076_abnormal_cell_differentiation1.68910112
35MP0002697_abnormal_eye_size1.66751010
36MP0002184_abnormal_innervation1.65518155
37MP0003315_abnormal_perineum_morphology1.64911852
38MP0000350_abnormal_cell_proliferation1.63074960
39MP0004811_abnormal_neuron_physiology1.61095997
40MP0002249_abnormal_larynx_morphology1.60963356
41MP0000049_abnormal_middle_ear1.59906570
42* MP0002733_abnormal_thermal_nociception1.59786487
43MP0000462_abnormal_digestive_system1.58613075
44MP0002572_abnormal_emotion/affect_behav1.58217177
45MP0001188_hyperpigmentation1.55965054
46MP0003172_abnormal_lysosome_physiology1.54063299
47MP0005423_abnormal_somatic_nervous1.53458149
48MP0002282_abnormal_trachea_morphology1.52832369
49MP0000566_synostosis1.52512868
50MP0002084_abnormal_developmental_patter1.51936575
51MP0008058_abnormal_DNA_repair1.51657772
52MP0005174_abnormal_tail_pigmentation1.49277649
53MP0001348_abnormal_lacrimal_gland1.47848526
54MP0003937_abnormal_limbs/digits/tail_de1.45642202
55MP0004858_abnormal_nervous_system1.44788291
56MP0002877_abnormal_melanocyte_morpholog1.39987594
57MP0008007_abnormal_cellular_replicative1.39345026
58MP0009046_muscle_twitch1.38479397
59MP0002080_prenatal_lethality1.37374655
60MP0005187_abnormal_penis_morphology1.36957667
61MP0002234_abnormal_pharynx_morphology1.36497925
62MP0003861_abnormal_nervous_system1.35007413
63* MP0001970_abnormal_pain_threshold1.33932195
64MP0002085_abnormal_embryonic_tissue1.32622127
65MP0003984_embryonic_growth_retardation1.27334042
66MP0008877_abnormal_DNA_methylation1.27169483
67MP0002163_abnormal_gland_morphology1.23963150
68MP0002734_abnormal_mechanical_nocicepti1.22958326
69MP0001293_anophthalmia1.22719780
70MP0002088_abnormal_embryonic_growth/wei1.19249231
71MP0002152_abnormal_brain_morphology1.18524911
72MP0002092_abnormal_eye_morphology1.18151930
73MP0010352_gastrointestinal_tract_polyps1.17606677
74MP0000015_abnormal_ear_pigmentation1.16539561
75MP0000534_abnormal_ureter_morphology1.14604633
76MP0002882_abnormal_neuron_morphology1.14424650
77MP0005248_abnormal_Harderian_gland1.13277305
78MP0001697_abnormal_embryo_size1.13183189
79MP0003137_abnormal_impulse_conducting1.12998718
80MP0003329_amyloid_beta_deposits1.12204686
81MP0000003_abnormal_adipose_tissue1.11846889
82MP0002086_abnormal_extraembryonic_tissu1.11248800
83MP0005397_hematopoietic_system_phenotyp1.11028303
84MP0001545_abnormal_hematopoietic_system1.11028303
85MP0004197_abnormal_fetal_growth/weight/1.10090482
86MP0004142_abnormal_muscle_tone1.10043227
87MP0002064_seizures1.09806753
88MP0001340_abnormal_eyelid_morphology1.09511475
89MP0002269_muscular_atrophy1.08958157
90MP0000639_abnormal_adrenal_gland1.08269132
91MP0010307_abnormal_tumor_latency1.06742012
92MP0010094_abnormal_chromosome_stability1.05670426
93MP0005501_abnormal_skin_physiology1.04664227
94MP0005666_abnormal_adipose_tissue1.04416260
95MP0003786_premature_aging1.04073270
96MP0003122_maternal_imprinting1.04030911
97MP0003755_abnormal_palate_morphology1.03220723
98MP0003453_abnormal_keratinocyte_physiol1.02016223
99MP0001440_abnormal_grooming_behavior1.01053657
100MP0002735_abnormal_chemical_nociception0.99182858
101MP0002116_abnormal_craniofacial_bone0.98487077
102MP0000428_abnormal_craniofacial_morphol0.98427675
103MP0000371_diluted_coat_color0.98271237
104MP0009250_abnormal_appendicular_skeleto0.97777770
105MP0003567_abnormal_fetal_cardiomyocyte0.96808598
106MP0006292_abnormal_olfactory_placode0.96516037
107MP0001849_ear_inflammation0.96299855
108MP0000313_abnormal_cell_death0.96230758
109MP0002751_abnormal_autonomic_nervous0.96180624
110MP0005386_behavior/neurological_phenoty0.95258794
111MP0004924_abnormal_behavior0.95258794
112MP0009379_abnormal_foot_pigmentation0.94995646
113MP0002081_perinatal_lethality0.94115676
114MP0003938_abnormal_ear_development0.93829639
115* MP0002066_abnormal_motor_capabilities/c0.93679238
116MP0001661_extended_life_span0.93435590
117MP0001286_abnormal_eye_development0.93080286
118MP0005451_abnormal_body_composition0.92839339
119MP0008932_abnormal_embryonic_tissue0.92252789
120MP0002822_catalepsy0.92093423
121MP0002932_abnormal_joint_morphology0.91941544
122MP0001502_abnormal_circadian_rhythm0.90968849
123MP0003385_abnormal_body_wall0.90649619
124MP0003718_maternal_effect0.90565736
125MP0003115_abnormal_respiratory_system0.90522825
126MP0002111_abnormal_tail_morphology0.90509550
127MP0001968_abnormal_touch/_nociception0.90281157
128MP0004885_abnormal_endolymph0.90114949
129MP0005375_adipose_tissue_phenotype0.89688281
130MP0003880_abnormal_central_pattern0.89297062
131MP0003935_abnormal_craniofacial_develop0.88830404
132MP0000516_abnormal_urinary_system0.87338234
133MP0005367_renal/urinary_system_phenotyp0.87338234
134MP0000751_myopathy0.87141615
135MP0009703_decreased_birth_body0.85905019
136MP0002114_abnormal_axial_skeleton0.85640131
137MP0002089_abnormal_postnatal_growth/wei0.85443369
138MP0010234_abnormal_vibrissa_follicle0.85417413
139MP0002160_abnormal_reproductive_system0.83078676
140MP0003121_genomic_imprinting0.82799262
141MP0009745_abnormal_behavioral_response0.81716680
142MP0003942_abnormal_urinary_system0.81697184
143MP0003634_abnormal_glial_cell0.81445810
144MP0009053_abnormal_anal_canal0.81417032
145MP0002796_impaired_skin_barrier0.81349196
146MP0000733_abnormal_muscle_development0.80881551
147MP0002557_abnormal_social/conspecific_i0.80353281
148MP0004957_abnormal_blastocyst_morpholog0.78919543
149MP0006276_abnormal_autonomic_nervous0.78867879
150MP0005380_embryogenesis_phenotype0.77822193
151MP0001672_abnormal_embryogenesis/_devel0.77822193
152MP0000762_abnormal_tongue_morphology0.76989790
153MP0000681_abnormal_thyroid_gland0.75695323
154MP0000470_abnormal_stomach_morphology0.75113682
155MP0010768_mortality/aging0.74585677
156MP0002233_abnormal_nose_morphology0.71678389

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)4.64253537
2Facial hemangioma (HP:0000329)4.61370637
3Annular pancreas (HP:0001734)4.52648200
4Turricephaly (HP:0000262)4.38748104
5Rib fusion (HP:0000902)4.37561798
6Broad distal phalanx of finger (HP:0009836)3.66195921
7Myokymia (HP:0002411)3.57876224
8Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.49196755
9Rectovaginal fistula (HP:0000143)3.48612798
10Rectal fistula (HP:0100590)3.48612798
11Truncus arteriosus (HP:0001660)3.43743847
12Coronal craniosynostosis (HP:0004440)3.42860387
13Alopecia of scalp (HP:0002293)3.30990373
14Abnormality of the labia minora (HP:0012880)3.25466948
15Increased IgM level (HP:0003496)3.25074735
16Male infertility (HP:0003251)3.24300822
17Abnormality of the aortic arch (HP:0012303)3.20080078
18Tongue fasciculations (HP:0001308)3.14259840
19Aplasia/Hypoplasia of the sacrum (HP:0008517)3.13108117
20Anteriorly placed anus (HP:0001545)3.11298928
21Pustule (HP:0200039)3.09268044
22Hyperthyroidism (HP:0000836)3.09206614
23Vaginal fistula (HP:0004320)3.08112321
24Birth length less than 3rd percentile (HP:0003561)3.07710233
25Intestinal fistula (HP:0100819)3.06089651
26Orthostatic hypotension (HP:0001278)3.03696048
27Hyperacusis (HP:0010780)2.98530308
28Abnormality of the lower motor neuron (HP:0002366)2.98259595
29Alacrima (HP:0000522)2.95325127
30Ulnar bowing (HP:0003031)2.95169209
31Astrocytoma (HP:0009592)2.95117872
32Abnormality of the astrocytes (HP:0100707)2.95117872
33Broad alveolar ridges (HP:0000187)2.92555661
34Short humerus (HP:0005792)2.89498351
35Choanal stenosis (HP:0000452)2.89096423
36Muscle fibrillation (HP:0010546)2.87669798
37High anterior hairline (HP:0009890)2.86806204
38Aplasia/hypoplasia of the humerus (HP:0006507)2.86583777
39Reticulocytopenia (HP:0001896)2.85838727
40Congenital hip dislocation (HP:0001374)2.85026582
41Poikiloderma (HP:0001029)2.83323969
42Akinesia (HP:0002304)2.80324938
43Visual hallucinations (HP:0002367)2.79266661
44Insomnia (HP:0100785)2.78595715
45Short chin (HP:0000331)2.73059299
46Obstructive sleep apnea (HP:0002870)2.67659256
47Transposition of the great arteries (HP:0001669)2.62228676
48Abnormal connection of the cardiac segments (HP:0011545)2.62228676
49Abnormal ventriculo-arterial connection (HP:0011563)2.62228676
50Amyotrophic lateral sclerosis (HP:0007354)2.61598412
51Mutism (HP:0002300)2.59754767
52Growth hormone excess (HP:0000845)2.56672668
53Fetal akinesia sequence (HP:0001989)2.53989529
54Vertebral hypoplasia (HP:0008417)2.52961595
55Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.52961595
56Septate vagina (HP:0001153)2.52479200
57Dysautonomia (HP:0002459)2.51277222
58Hamartoma (HP:0010566)2.48775443
59Narrow nasal bridge (HP:0000446)2.47413465
60Intestinal atresia (HP:0011100)2.47002141
61Progressive muscle weakness (HP:0003323)2.46755665
62Hypercortisolism (HP:0001578)2.40929769
63Abnormality of the phalanges of the hallux (HP:0010057)2.38715632
64Increased nuchal translucency (HP:0010880)2.38585880
65Hypochromic microcytic anemia (HP:0004840)2.38406919
66Abnormality of cells of the erythroid lineage (HP:0012130)2.34926855
67Diminished movement (HP:0002374)2.34708293
68Hypotrichosis (HP:0001006)2.33090431
69Congenital malformation of the right heart (HP:0011723)2.31729517
70Double outlet right ventricle (HP:0001719)2.31729517
71Absent radius (HP:0003974)2.31263368
72Selective tooth agenesis (HP:0001592)2.31029904
73Abnormality of cochlea (HP:0000375)2.27874420
74Absent forearm bone (HP:0003953)2.25386425
75Aplasia involving forearm bones (HP:0009822)2.25386425
76Increased number of teeth (HP:0011069)2.24741722
77Mucopolysacchariduria (HP:0008155)2.23594489
78Urinary glycosaminoglycan excretion (HP:0003541)2.23594489
79Aplasia of the musculature (HP:0100854)2.21624884
80Patellar aplasia (HP:0006443)2.20978207
81Aqueductal stenosis (HP:0002410)2.18664615
82Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17276456
83Duplication of thumb phalanx (HP:0009942)2.17034928
84Decreased lacrimation (HP:0000633)2.16979384
85Atresia of the external auditory canal (HP:0000413)2.16710865
86Pointed chin (HP:0000307)2.16384647
87Abnormal number of incisors (HP:0011064)2.15968952
88Long palpebral fissure (HP:0000637)2.14596799
89Cholecystitis (HP:0001082)2.14448374
90Abnormal gallbladder physiology (HP:0012438)2.14448374
91Patellar dislocation (HP:0002999)2.11767484
92Overriding aorta (HP:0002623)2.11556034
93Heterotopia (HP:0002282)2.10658688
94Abnormality of polysaccharide metabolism (HP:0011012)2.10096354
95Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10096354
96Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10096354
97Bowel incontinence (HP:0002607)2.09918591
98Bifid uvula (HP:0000193)2.09369373
99Abnormal large intestine physiology (HP:0012700)2.06790754
100Aplasia/Hypoplasia of the patella (HP:0006498)2.05595967
101Supranuclear gaze palsy (HP:0000605)2.04086771
102Proximal placement of thumb (HP:0009623)2.03840308
103Glioma (HP:0009733)2.03820324
104Breast hypoplasia (HP:0003187)2.02454821
105Abnormality of reticulocytes (HP:0004312)2.01709635
106Partial duplication of thumb phalanx (HP:0009944)2.01173403
107Clumsiness (HP:0002312)2.00261947
108Abnormality of male internal genitalia (HP:0000022)1.99862935
109Cortical dysplasia (HP:0002539)1.99729352
110Abnormal hemoglobin (HP:0011902)1.99539710
111Elfin facies (HP:0004428)1.98762227
112Capillary hemangiomas (HP:0005306)1.97966925
113Dysmetric saccades (HP:0000641)1.97851121
114Large for gestational age (HP:0001520)1.97719580
115Disproportionate tall stature (HP:0001519)1.97683376
116Unilateral renal agenesis (HP:0000122)1.97041431
117Dysostosis multiplex (HP:0000943)1.96725593
118Chromsome breakage (HP:0040012)1.96246591
119Renal duplication (HP:0000075)1.94314302
120Partial duplication of the phalanx of hand (HP:0009999)1.93820763
121Atrophy/Degeneration involving motor neurons (HP:0007373)1.92782654
122Deep palmar crease (HP:0006191)1.91663478
123Premature skin wrinkling (HP:0100678)1.91497400
124Abnormal number of erythroid precursors (HP:0012131)1.90997340
125Deviation of the thumb (HP:0009603)1.90558651
126Limb dystonia (HP:0002451)1.90399259
127Hypoparathyroidism (HP:0000829)1.90084501
128Basal cell carcinoma (HP:0002671)1.89991976
129Absence seizures (HP:0002121)1.88887539
130Epileptic encephalopathy (HP:0200134)1.87768768
131Ankle clonus (HP:0011448)1.87404591
132Cerebral aneurysm (HP:0004944)1.87343645
133Failure to thrive in infancy (HP:0001531)1.87135264
134Shawl scrotum (HP:0000049)1.86691850
135Vertebral fusion (HP:0002948)1.86537626
136Squamous cell carcinoma (HP:0002860)1.83886733
137Microretrognathia (HP:0000308)1.83624404
138Split hand (HP:0001171)1.83213888
139Spastic diplegia (HP:0001264)1.83165838
140Achilles tendon contracture (HP:0001771)1.82691241
141Abnormality of the distal phalanx of the thumb (HP:0009617)1.82133412
142Microvesicular hepatic steatosis (HP:0001414)1.79833729
143Polyphagia (HP:0002591)1.78811824
144Poor suck (HP:0002033)1.75547786
145Hypokinesia (HP:0002375)1.75160071
146Multiple enchondromatosis (HP:0005701)1.74503057
147Pseudobulbar signs (HP:0002200)1.73899900
148Neoplasm of the oral cavity (HP:0100649)1.73784452
149Hypotelorism (HP:0000601)1.73343850
150Generalized hypotonia (HP:0001290)1.73069943
151Ependymoma (HP:0002888)1.72372647
152Partial agenesis of the corpus callosum (HP:0001338)1.72326140
153Sleep apnea (HP:0010535)1.72205754
154Horseshoe kidney (HP:0000085)1.71978833
155Atonic seizures (HP:0010819)1.71653697
156Albinism (HP:0001022)1.71255325
157Focal seizures (HP:0007359)1.71159836
158Abnormality of the fetal cardiovascular system (HP:0010948)1.70625921
159Abnormal umbilical cord blood vessels (HP:0011403)1.70625921
160Single umbilical artery (HP:0001195)1.70625921
161Facial cleft (HP:0002006)1.69868202
162Arnold-Chiari malformation (HP:0002308)1.69304289
163Abnormality of chromosome segregation (HP:0002916)1.68888219
164Morphological abnormality of the inner ear (HP:0011390)1.68538250
165Abnormality of the calcaneus (HP:0008364)1.68298708
166Obsessive-compulsive behavior (HP:0000722)1.67356426
167Abnormally folded helix (HP:0008544)1.66736543
168Optic nerve coloboma (HP:0000588)1.64904142
169Preauricular skin tag (HP:0000384)1.64853504
170Abnormality of the umbilical cord (HP:0010881)1.64715041
171Atelectasis (HP:0100750)1.62287885
172Reticulocytosis (HP:0001923)1.61859013
173Calcaneovalgus deformity (HP:0001848)1.61418194
174Short middle phalanx of the 5th finger (HP:0004220)1.60964404
175Aplasia involving bones of the extremities (HP:0009825)1.60941771
176Aplasia involving bones of the upper limbs (HP:0009823)1.60941771
177Aplasia of the phalanges of the hand (HP:0009802)1.60941771
178Cutaneous syndactyly (HP:0012725)1.59161458
179Hepatoblastoma (HP:0002884)1.57540151
180Cheekbone underdevelopment (HP:0010669)1.57512127
181Abnormality of the tricuspid valve (HP:0001702)1.57240664
182Rectal prolapse (HP:0002035)1.56610513
183Abnormality of the gallbladder (HP:0005264)1.56027436

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.96391340
2EEF2K4.27516072
3MARK14.26605696
4MAP3K64.05036082
5DDR24.04163977
6MAPK153.82056465
7SMG13.77193731
8LATS23.23669887
9MAP3K93.21801286
10TYRO32.98108427
11CDK122.68297941
12CDC72.66944381
13BUB12.65424830
14MAP3K112.65381859
15NME22.62292232
16UHMK12.44110388
17PHKG12.34127586
18PHKG22.34127586
19DAPK12.34073175
20PINK12.29640152
21MATK2.27095694
22FGR2.24136823
23DYRK22.14976822
24VRK21.90033170
25TTK1.82929495
26PDGFRA1.75309952
27IRAK31.74379282
28CAMK1D1.67548976
29SRPK11.57735148
30BMX1.55878482
31PRKD21.52783965
32NTRK21.46874691
33DYRK1B1.40178774
34BRAF1.39270937
35CAMK1G1.36775076
36ERBB31.35734955
37MINK11.34910545
38PAK61.30393085
39TAOK11.19677746
40PIM21.19316399
41KDR1.17909791
42ATR1.15996644
43CSK1.11763475
44NME11.11514225
45ARAF1.11360521
46BRSK11.11259480
47TSSK61.07456939
48YES11.01254022
49CDC42BPA1.01043259
50CHEK11.00364738
51MAP3K80.99833631
52SIK10.99286001
53PKN20.98835613
54TAF10.98596677
55RPS6KB20.97002452
56ILK0.96814799
57CHEK20.94783670
58MAP3K40.92203243
59KSR20.92133236
60AKT20.91557302
61NEK20.90410416
62CDK80.88879126
63EPHA20.86540422
64STK160.85382476
65KSR10.84678541
66CDK70.80882717
67AKT30.80724757
68GSK3A0.79915035
69CDK60.77284317
70CDK40.75935847
71RPS6KC10.75459274
72RPS6KL10.75459274
73ZAK0.74859801
74PRPF4B0.73915346
75SIK20.72872419
76BRD40.72818169
77WEE10.71996439
78RAF10.70984650
79MARK20.70933379
80CDK10.70418445
81AURKB0.69616818
82PRKAA10.69540276
83CDK150.69080566
84STK40.69029076
85CDK180.69015594
86NEK10.68041260
87PRKCZ0.67920978
88PLK40.67829574
89MAPK130.67010903
90CDK50.65307781
91CDK140.63736412
92ALK0.63396379
93NTRK10.63201222
94CSNK1G20.62994371
95CDK11A0.62673935
96MAP2K70.62475337
97CSNK1G10.62346516
98LIMK10.61093116
99RPS6KA10.61085561
100DAPK20.60665767
101PLK30.60554744
102NTRK30.60180805
103TRIB30.59798372
104LRRK20.59206757
105MAP3K100.58713707
106RPS6KA60.58150371
107EPHB20.57225291
108MTOR0.57063612
109MAP2K20.55536854
110DYRK30.55045153
111RIPK10.54818793
112IRAK20.54748696
113TESK10.53240040
114RPS6KA20.52693368
115STK380.52162620
116ATM0.51510577
117PBK0.50466516
118AURKA0.49448880
119CSNK1E0.49358319
120PAK40.49127023
121RPS6KA40.48991935
122PRKCI0.48638769
123TLK10.47857091
124CSNK1G30.47844257
125PTK60.46288653
126DAPK30.45687234
127RPS6KA50.45555474
128MAPK110.45499229
129VRK10.45273955
130HIPK20.45220819
131PRKD30.45031727
132CDK190.44575655
133CAMK2A0.43969144
134PIM10.43342049
135CLK10.43040745
136SCYL20.42122283
137EIF2AK10.42022603
138PAK10.40662219
139MKNK10.40532175
140PLK10.38664783
141EGFR0.37652868
142TRPM70.37321174
143CAMK2B0.35303861
144MAPK100.34917465
145MAPK40.33551996
146LATS10.33491572
147TAOK20.33273564
148CDK20.31266685
149MAPK90.30938107
150PTK20.30567834
151PAK30.29201983
152PDGFRB0.28114718
153CSNK1A1L0.27706679
154RPS6KB10.26642026
155CAMK2G0.26091868
156SGK10.25316563
157MAP2K40.24953745
158MAPKAPK30.23938330
159TESK20.23832221
160RPS6KA30.23716071

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.38160829
2Base excision repair_Homo sapiens_hsa034102.74864276
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.70881730
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.67034331
5mTOR signaling pathway_Homo sapiens_hsa041502.51342946
6Hippo signaling pathway_Homo sapiens_hsa043902.45398936
7Ribosome_Homo sapiens_hsa030102.41714794
8Mismatch repair_Homo sapiens_hsa034302.30605907
9Hedgehog signaling pathway_Homo sapiens_hsa043402.22596671
10Circadian rhythm_Homo sapiens_hsa047102.01569287
11Synaptic vesicle cycle_Homo sapiens_hsa047211.91643375
12Vitamin B6 metabolism_Homo sapiens_hsa007501.87376251
13Oocyte meiosis_Homo sapiens_hsa041141.86171542
14Notch signaling pathway_Homo sapiens_hsa043301.85839166
15Gap junction_Homo sapiens_hsa045401.83415801
16Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.72385590
17mRNA surveillance pathway_Homo sapiens_hsa030151.68952646
18Longevity regulating pathway - mammal_Homo sapiens_hsa042111.67790260
19One carbon pool by folate_Homo sapiens_hsa006701.62175217
20ErbB signaling pathway_Homo sapiens_hsa040121.62048483
21Basal cell carcinoma_Homo sapiens_hsa052171.58436789
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54447916
23Endometrial cancer_Homo sapiens_hsa052131.51680847
24Pyrimidine metabolism_Homo sapiens_hsa002401.49595794
25Nicotine addiction_Homo sapiens_hsa050331.47088056
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46452649
27Bladder cancer_Homo sapiens_hsa052191.39871000
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.39029371
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37726166
30GABAergic synapse_Homo sapiens_hsa047271.31351170
31Carbon metabolism_Homo sapiens_hsa012001.30663884
32Dorso-ventral axis formation_Homo sapiens_hsa043201.30439242
33* Wnt signaling pathway_Homo sapiens_hsa043101.30258579
34Pentose phosphate pathway_Homo sapiens_hsa000301.26504453
35Dopaminergic synapse_Homo sapiens_hsa047281.25703886
36TGF-beta signaling pathway_Homo sapiens_hsa043501.25056363
37* Axon guidance_Homo sapiens_hsa043601.24599570
38GnRH signaling pathway_Homo sapiens_hsa049121.23132822
39Estrogen signaling pathway_Homo sapiens_hsa049151.21198898
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19973989
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19280234
42RNA polymerase_Homo sapiens_hsa030201.17951494
43* Colorectal cancer_Homo sapiens_hsa052101.17921568
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16897153
45Olfactory transduction_Homo sapiens_hsa047401.16260769
46DNA replication_Homo sapiens_hsa030301.14534861
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11953190
48Tight junction_Homo sapiens_hsa045301.10483249
49Insulin signaling pathway_Homo sapiens_hsa049101.08571798
50Homologous recombination_Homo sapiens_hsa034401.08012793
51RNA transport_Homo sapiens_hsa030131.07436097
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05026517
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.04810388
54Long-term depression_Homo sapiens_hsa047301.02864121
55Non-homologous end-joining_Homo sapiens_hsa034501.01115097
56Shigellosis_Homo sapiens_hsa051311.00730405
57p53 signaling pathway_Homo sapiens_hsa041150.98655298
58Alcoholism_Homo sapiens_hsa050340.97521936
59Glioma_Homo sapiens_hsa052140.96915224
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96362876
61Pyruvate metabolism_Homo sapiens_hsa006200.96171706
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96115146
63* VEGF signaling pathway_Homo sapiens_hsa043700.95227979
64Lysine degradation_Homo sapiens_hsa003100.95125742
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94874128
66Amphetamine addiction_Homo sapiens_hsa050310.93871311
67Long-term potentiation_Homo sapiens_hsa047200.92691157
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92227485
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92065280
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91315674
71Arginine and proline metabolism_Homo sapiens_hsa003300.90643691
72AMPK signaling pathway_Homo sapiens_hsa041520.90504503
73Glutamatergic synapse_Homo sapiens_hsa047240.90388932
74Melanogenesis_Homo sapiens_hsa049160.89500145
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89462022
76* Adherens junction_Homo sapiens_hsa045200.89227235
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89206821
78Fructose and mannose metabolism_Homo sapiens_hsa000510.88154944
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87970280
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86324159
81Galactose metabolism_Homo sapiens_hsa000520.85492824
82Folate biosynthesis_Homo sapiens_hsa007900.85382340
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85007156
84Circadian entrainment_Homo sapiens_hsa047130.84893222
85Chronic myeloid leukemia_Homo sapiens_hsa052200.84425980
86Endocytosis_Homo sapiens_hsa041440.84359044
87* Choline metabolism in cancer_Homo sapiens_hsa052310.83303248
88Cholinergic synapse_Homo sapiens_hsa047250.83067448
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82902331
90Fanconi anemia pathway_Homo sapiens_hsa034600.82494662
91MicroRNAs in cancer_Homo sapiens_hsa052060.81827771
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.79580341
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79475301
94Morphine addiction_Homo sapiens_hsa050320.79141563
95Purine metabolism_Homo sapiens_hsa002300.78772094
96Steroid biosynthesis_Homo sapiens_hsa001000.78340650
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78119010
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76042325
99Spliceosome_Homo sapiens_hsa030400.75040415
100Sulfur relay system_Homo sapiens_hsa041220.74738121
101Oxytocin signaling pathway_Homo sapiens_hsa049210.73239740
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72165803
103Renal cell carcinoma_Homo sapiens_hsa052110.70993848
104Selenocompound metabolism_Homo sapiens_hsa004500.70949578
105Nucleotide excision repair_Homo sapiens_hsa034200.70193534
106* MAPK signaling pathway_Homo sapiens_hsa040100.69633354
107Cell cycle_Homo sapiens_hsa041100.69589166
108* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69534382
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69419902
110Vibrio cholerae infection_Homo sapiens_hsa051100.68625350
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68448845
112N-Glycan biosynthesis_Homo sapiens_hsa005100.67586076
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.67362728
114Biosynthesis of amino acids_Homo sapiens_hsa012300.65800258
115Basal transcription factors_Homo sapiens_hsa030220.61758058
116Fatty acid metabolism_Homo sapiens_hsa012120.60982328
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57962265
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56189296
119Prion diseases_Homo sapiens_hsa050200.54870843
120Serotonergic synapse_Homo sapiens_hsa047260.54452825
121Prolactin signaling pathway_Homo sapiens_hsa049170.54199936
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53386252
123Salivary secretion_Homo sapiens_hsa049700.52753789
124Arginine biosynthesis_Homo sapiens_hsa002200.52309681
125Insulin secretion_Homo sapiens_hsa049110.52270191
126Acute myeloid leukemia_Homo sapiens_hsa052210.51368669
127Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51269288
128Thyroid cancer_Homo sapiens_hsa052160.51249854
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50484517
130Proteoglycans in cancer_Homo sapiens_hsa052050.49336145
131Cocaine addiction_Homo sapiens_hsa050300.48987510
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47859300
133Non-small cell lung cancer_Homo sapiens_hsa052230.46651103
134Viral carcinogenesis_Homo sapiens_hsa052030.44883739
135Huntingtons disease_Homo sapiens_hsa050160.44196897
136Prostate cancer_Homo sapiens_hsa052150.41835773
137Melanoma_Homo sapiens_hsa052180.40949984
138* Ras signaling pathway_Homo sapiens_hsa040140.39949017
139* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39936221
140Gastric acid secretion_Homo sapiens_hsa049710.39839753
141Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39037553
142RNA degradation_Homo sapiens_hsa030180.38433877
143Glucagon signaling pathway_Homo sapiens_hsa049220.38410057

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