RACGAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.84044450
2mitotic sister chromatid segregation (GO:0000070)5.54888320
3mitotic chromosome condensation (GO:0007076)5.47115356
4protein localization to chromosome, centromeric region (GO:0071459)5.31630531
5sister chromatid segregation (GO:0000819)5.30623181
6mitotic metaphase plate congression (GO:0007080)5.25386924
7kinetochore organization (GO:0051383)5.00140230
8* regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.86488862
9regulation of spindle organization (GO:0090224)4.73621200
10DNA unwinding involved in DNA replication (GO:0006268)4.70743012
11metaphase plate congression (GO:0051310)4.57544812
12attachment of spindle microtubules to kinetochore (GO:0008608)4.43484440
13CENP-A containing nucleosome assembly (GO:0034080)4.41905668
14kinetochore assembly (GO:0051382)4.37725402
15mitotic nuclear envelope disassembly (GO:0007077)4.35348320
16chromatin remodeling at centromere (GO:0031055)4.34961720
17establishment of chromosome localization (GO:0051303)4.34404792
18positive regulation of chromosome segregation (GO:0051984)4.32679259
19DNA strand elongation involved in DNA replication (GO:0006271)4.22733991
20regulation of mitotic spindle organization (GO:0060236)4.14784001
21positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.14724756
22positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.14724756
23positive regulation of mitotic sister chromatid separation (GO:1901970)4.14724756
24nuclear pore organization (GO:0006999)4.14640377
25DNA replication-independent nucleosome organization (GO:0034724)4.10780670
26DNA replication-independent nucleosome assembly (GO:0006336)4.10780670
27DNA replication checkpoint (GO:0000076)4.09809982
28establishment of integrated proviral latency (GO:0075713)4.09528650
29DNA replication initiation (GO:0006270)4.09109462
30protein localization to chromosome (GO:0034502)4.07925001
31membrane disassembly (GO:0030397)4.06155136
32nuclear envelope disassembly (GO:0051081)4.06155136
33DNA strand elongation (GO:0022616)4.01580204
34spindle checkpoint (GO:0031577)4.00925973
35DNA replication-dependent nucleosome organization (GO:0034723)3.98276550
36DNA replication-dependent nucleosome assembly (GO:0006335)3.98276550
37nuclear pore complex assembly (GO:0051292)3.97843284
38* regulation of chromosome segregation (GO:0051983)3.97358096
39telomere maintenance via semi-conservative replication (GO:0032201)3.89966802
40regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.87126850
41spindle assembly checkpoint (GO:0071173)3.84157191
42negative regulation of chromosome segregation (GO:0051985)3.83615328
43histone exchange (GO:0043486)3.83096764
44regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.82827360
45chromosome segregation (GO:0007059)3.79090328
46negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.76455553
47negative regulation of sister chromatid segregation (GO:0033046)3.76455553
48negative regulation of mitotic sister chromatid separation (GO:2000816)3.76455553
49negative regulation of mitotic sister chromatid segregation (GO:0033048)3.76455553
50regulation of mitotic metaphase/anaphase transition (GO:0030071)3.76282799
51mitotic recombination (GO:0006312)3.75347637
52mitotic spindle assembly checkpoint (GO:0007094)3.74590932
53meiotic chromosome segregation (GO:0045132)3.73623956
54DNA ligation (GO:0006266)3.73141542
55chromosome condensation (GO:0030261)3.72749662
56mitotic spindle checkpoint (GO:0071174)3.71244184
57regulation of translational fidelity (GO:0006450)3.70365520
58regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.68754927
59negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.66708520
60telomere maintenance via recombination (GO:0000722)3.62465627
61protein complex localization (GO:0031503)3.62335875
62regulation of sister chromatid segregation (GO:0033045)3.58609224
63regulation of mitotic sister chromatid separation (GO:0010965)3.58609224
64regulation of mitotic sister chromatid segregation (GO:0033047)3.58609224
65chromatin assembly or disassembly (GO:0006333)3.52761999
66regulation of centrosome cycle (GO:0046605)3.52456896
67regulation of sister chromatid cohesion (GO:0007063)3.51516690
68microtubule depolymerization (GO:0007019)3.45127847
69Golgi transport vesicle coating (GO:0048200)3.41517696
70COPI coating of Golgi vesicle (GO:0048205)3.41517696
71mitotic sister chromatid cohesion (GO:0007064)3.40487386
72ATP-dependent chromatin remodeling (GO:0043044)3.33631628
73histone-serine phosphorylation (GO:0035404)3.31583670
74cellular protein complex localization (GO:0034629)3.28692525
75nuclear envelope organization (GO:0006998)3.27914797
76DNA packaging (GO:0006323)3.26359487
77nucleobase biosynthetic process (GO:0046112)3.24516379
78DNA synthesis involved in DNA repair (GO:0000731)3.24501533
79telomere maintenance via telomere lengthening (GO:0010833)3.23281360
80DNA geometric change (GO:0032392)3.20565902
81DNA duplex unwinding (GO:0032508)3.20286114
82protein K6-linked ubiquitination (GO:0085020)3.18767125
83* mitotic cytokinesis (GO:0000281)3.18077785
84establishment of mitotic spindle localization (GO:0040001)3.15056624
85establishment of viral latency (GO:0019043)3.12263818
86nucleotide-excision repair, DNA gap filling (GO:0006297)3.11471095
87spindle organization (GO:0007051)3.10030848
88mitotic spindle organization (GO:0007052)3.09956474
89pore complex assembly (GO:0046931)3.09360472
90non-recombinational repair (GO:0000726)3.08301343
91double-strand break repair via nonhomologous end joining (GO:0006303)3.08301343
92mitotic cell cycle (GO:0000278)3.08257167
93negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.07501250
94regulation of exit from mitosis (GO:0007096)3.07195757
95nucleobase-containing small molecule interconversion (GO:0015949)3.06865117
96formation of translation preinitiation complex (GO:0001731)3.06378749
97DNA conformation change (GO:0071103)3.05192740
98folic acid-containing compound biosynthetic process (GO:0009396)3.05068238
99regulation of centriole replication (GO:0046599)3.03672905
100purine nucleobase biosynthetic process (GO:0009113)3.03401073
101DNA topological change (GO:0006265)3.03336510
102regulation of RNA export from nucleus (GO:0046831)2.97795532
103regulation of double-strand break repair via homologous recombination (GO:0010569)2.97342112
104IMP biosynthetic process (GO:0006188)2.95162379
105regulation of centrosome duplication (GO:0010824)2.93972474
106microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.93876393
107translesion synthesis (GO:0019985)2.93578466
108chromosome organization (GO:0051276)2.91408707
109ribosome assembly (GO:0042255)2.89592602
110negative regulation of mitosis (GO:0045839)2.88321007
111histone phosphorylation (GO:0016572)2.87337271
112mitotic G2/M transition checkpoint (GO:0044818)2.87044109
113postreplication repair (GO:0006301)2.83234730
114negative regulation of RNA splicing (GO:0033119)2.82047752
115regulation of telomere maintenance via telomerase (GO:0032210)2.81286467
116regulation of histone H3-K9 methylation (GO:0051570)2.81077110
117dosage compensation (GO:0007549)2.80040721
118mitotic cell cycle checkpoint (GO:0007093)2.78757371
119regulation of nuclear cell cycle DNA replication (GO:0033262)2.78371038
120heterochromatin organization (GO:0070828)2.77563394
121spindle assembly involved in mitosis (GO:0090307)2.76273124
122mitotic nuclear division (GO:0007067)2.75834735

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.87138589
2* FOXM1_23109430_ChIP-Seq_U2OS_Human7.46194878
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.52535061
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.33725181
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.61018825
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.10217612
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.02536685
8AR_21909140_ChIP-Seq_LNCAP_Human2.78686208
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.66874887
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.66618269
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46321583
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.44506894
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.35042957
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.26521051
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22658656
16XRN2_22483619_ChIP-Seq_HELA_Human2.17231363
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14986156
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.14958524
19* EST1_17652178_ChIP-ChIP_JURKAT_Human2.09378391
20* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08684076
21* ETS1_20019798_ChIP-Seq_JURKAT_Human2.02593920
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95541134
23MYC_22102868_ChIP-Seq_BL_Human1.84997197
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81634980
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81063595
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79153664
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.78913826
28* VDR_23849224_ChIP-Seq_CD4+_Human1.76553979
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70274054
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.66162700
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.64788353
32* CIITA_25753668_ChIP-Seq_RAJI_Human1.63498613
33FOXP3_21729870_ChIP-Seq_TREG_Human1.62360272
34DCP1A_22483619_ChIP-Seq_HELA_Human1.61470035
35TTF2_22483619_ChIP-Seq_HELA_Human1.59670119
36* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58509962
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57216126
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55119911
39GABP_19822575_ChIP-Seq_HepG2_Human1.50949963
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47484697
41ZNF263_19887448_ChIP-Seq_K562_Human1.45688238
42KDM5A_27292631_Chip-Seq_BREAST_Human1.44068896
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43059339
44* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41293782
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37086045
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34941834
47* ELK1_19687146_ChIP-ChIP_HELA_Human1.34633563
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32110174
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30261067
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27235108
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24690554
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23775814
53* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23753973
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23425059
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21129170
56* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21035485
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20817501
58VDR_21846776_ChIP-Seq_THP-1_Human1.20207720
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18977896
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17944183
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17319212
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16174581
63CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13169688
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12699593
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10913041
66TFEB_21752829_ChIP-Seq_HELA_Human1.09204713
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08921228
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07571376
69* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07192658
70TP63_17297297_ChIP-ChIP_HaCaT_Human1.06827141
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06435265
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05977579
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.05887559
74* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05453674
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05272620
76NANOG_21062744_ChIP-ChIP_HESCs_Human1.04520398
77* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04039238
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03645264
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.01969638
80SOX17_20123909_ChIP-Seq_XEN_Mouse1.01602662
81* CHD1_26751641_Chip-Seq_LNCaP_Human0.99805677
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98873863
83SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97957088
84ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96979276
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95408551
86* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95191555
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92017261
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91503921
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86958925
90CLOCK_20551151_ChIP-Seq_293T_Human0.86899142
91TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86056019
92ATF3_27146783_Chip-Seq_COLON_Human0.85394549
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85270933
94PKCTHETA_26484144_Chip-Seq_BREAST_Human0.84953985
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.83668948
96RBPJ_22232070_ChIP-Seq_NCS_Mouse0.82089234
97ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81116393
98EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.80945144
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80637951
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80251061
101SPI1_23547873_ChIP-Seq_NB4_Human0.77829001
102NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.77407890
103FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.77295359
104TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77288800
105TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77121577
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.77067261
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76303005
108PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.75594884
109MYC_18940864_ChIP-ChIP_HL60_Human0.75180210
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.73861324
111* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73253996
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.72637064
113NANOG_16153702_ChIP-ChIP_HESCs_Human0.72543830
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71324024
115TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.70986878
116CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.70150037
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.70015093
118NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.69976425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.14569495
2MP0003111_abnormal_nucleus_morphology4.86899877
3MP0010094_abnormal_chromosome_stability4.51153329
4MP0003077_abnormal_cell_cycle4.12624322
5MP0004957_abnormal_blastocyst_morpholog3.89462527
6MP0008057_abnormal_DNA_replication3.57961797
7MP0008007_abnormal_cellular_replicative2.77499116
8MP0008058_abnormal_DNA_repair2.60228914
9MP0008932_abnormal_embryonic_tissue2.55913579
10MP0010234_abnormal_vibrissa_follicle2.35848463
11MP0003123_paternal_imprinting2.34807253
12MP0010307_abnormal_tumor_latency2.31654571
13MP0000350_abnormal_cell_proliferation2.28547873
14* MP0001730_embryonic_growth_arrest2.24917752
15MP0010030_abnormal_orbit_morphology2.17810291
16MP0005076_abnormal_cell_differentiation2.05393057
17MP0010352_gastrointestinal_tract_polyps1.98936263
18MP0009697_abnormal_copulation1.89870370
19MP0001672_abnormal_embryogenesis/_devel1.85646737
20MP0005380_embryogenesis_phenotype1.85646737
21MP0001697_abnormal_embryo_size1.79052422
22MP0008877_abnormal_DNA_methylation1.78069240
23MP0004185_abnormal_adipocyte_glucose1.72848177
24MP0002396_abnormal_hematopoietic_system1.70650493
25MP0003984_embryonic_growth_retardation1.64481814
26* MP0002085_abnormal_embryonic_tissue1.64349024
27MP0004233_abnormal_muscle_weight1.63486351
28MP0003786_premature_aging1.61339723
29MP0002088_abnormal_embryonic_growth/wei1.61315136
30MP0000490_abnormal_crypts_of1.60186053
31* MP0002080_prenatal_lethality1.58125537
32MP0003121_genomic_imprinting1.57593632
33MP0004808_abnormal_hematopoietic_stem1.54845734
34MP0002084_abnormal_developmental_patter1.54250783
35MP0004197_abnormal_fetal_growth/weight/1.50705634
36MP0002086_abnormal_extraembryonic_tissu1.47533387
37MP0005623_abnormal_meninges_morphology1.47069690
38MP0003950_abnormal_plasma_membrane1.44702552
39MP0003705_abnormal_hypodermis_morpholog1.42808571
40MP0002009_preneoplasia1.39960924
41MP0003567_abnormal_fetal_cardiomyocyte1.38432043
42MP0001346_abnormal_lacrimal_gland1.35841141
43MP0003718_maternal_effect1.34241571
44MP0003941_abnormal_skin_development1.33194493
45MP0000313_abnormal_cell_death1.32323411
46MP0009278_abnormal_bone_marrow1.29926710
47MP0002019_abnormal_tumor_incidence1.27776661
48MP0000537_abnormal_urethra_morphology1.25998480
49MP0005501_abnormal_skin_physiology1.20136078
50MP0003937_abnormal_limbs/digits/tail_de1.17331290
51MP0003315_abnormal_perineum_morphology1.16441046
52MP0002210_abnormal_sex_determination1.14397197
53MP0000703_abnormal_thymus_morphology1.12549509
54MP0009333_abnormal_splenocyte_physiolog1.12377375
55MP0000733_abnormal_muscle_development1.06706938
56MP0000428_abnormal_craniofacial_morphol1.04863918
57MP0002060_abnormal_skin_morphology1.04006835
58MP0001293_anophthalmia1.03982641
59MP0000358_abnormal_cell_content/1.03405019
60MP0008438_abnormal_cutaneous_collagen1.03057156
61MP0002796_impaired_skin_barrier1.02904769
62MP0009053_abnormal_anal_canal1.01137667
63MP0006054_spinal_hemorrhage0.98881083
64MP0001145_abnormal_male_reproductive0.96831033
65MP0003763_abnormal_thymus_physiology0.95236352
66MP0002111_abnormal_tail_morphology0.94462126
67MP0001727_abnormal_embryo_implantation0.94121660
68MP0003115_abnormal_respiratory_system0.93542166
69MP0001929_abnormal_gametogenesis0.92430968
70MP0003119_abnormal_digestive_system0.91157528
71MP0003221_abnormal_cardiomyocyte_apopto0.89876192
72MP0005397_hematopoietic_system_phenotyp0.89737338
73MP0001545_abnormal_hematopoietic_system0.89737338
74MP0001661_extended_life_span0.89559608
75MP0003890_abnormal_embryonic-extraembry0.88727066
76MP0003385_abnormal_body_wall0.88585850
77MP0001849_ear_inflammation0.88579485
78MP0001348_abnormal_lacrimal_gland0.87439053
79MP0000627_abnormal_mammary_gland0.87125492
80MP0002092_abnormal_eye_morphology0.86585625
81MP0009672_abnormal_birth_weight0.85589272
82MP0005023_abnormal_wound_healing0.85586947
83MP0000762_abnormal_tongue_morphology0.84518994
84* MP0002398_abnormal_bone_marrow0.84484676
85MP0000579_abnormal_nail_morphology0.83121099
86MP0005621_abnormal_cell_physiology0.81357540
87MP0005451_abnormal_body_composition0.81014643
88MP0000653_abnormal_sex_gland0.80863891
89MP0002722_abnormal_immune_system0.80626867
90MP0000858_altered_metastatic_potential0.79801579
91MP0003935_abnormal_craniofacial_develop0.79163206
92MP0000432_abnormal_head_morphology0.78561478
93MP0002877_abnormal_melanocyte_morpholog0.78552945
94MP0001881_abnormal_mammary_gland0.78432936
95MP0009703_decreased_birth_body0.78405236
96MP0002932_abnormal_joint_morphology0.78282891
97MP0003566_abnormal_cell_adhesion0.78163976
98MP0004272_abnormal_basement_membrane0.77908964
99MP0001216_abnormal_epidermal_layer0.77845044
100MP0001119_abnormal_female_reproductive0.77763352
101MP0000569_abnormal_digit_pigmentation0.77759117
102MP0006035_abnormal_mitochondrial_morpho0.76036279
103MP0005384_cellular_phenotype0.75641253
104MP0004264_abnormal_extraembryonic_tissu0.75300265
105MP0005389_reproductive_system_phenotype0.73117206
106MP0003755_abnormal_palate_morphology0.72886955
107MP0002098_abnormal_vibrissa_morphology0.72160403
108MP0003453_abnormal_keratinocyte_physiol0.72032584
109MP0005257_abnormal_intraocular_pressure0.70349619
110MP0001243_abnormal_dermal_layer0.70243177
111MP0000689_abnormal_spleen_morphology0.69328696
112MP0000566_synostosis0.69232674
113MP0001286_abnormal_eye_development0.68514469
114MP0003699_abnormal_female_reproductive0.68245703
115MP0003943_abnormal_hepatobiliary_system0.68078914
116MP0001915_intracranial_hemorrhage0.67858670
117MP0000377_abnormal_hair_follicle0.67550831
118MP0002697_abnormal_eye_size0.67320736
119MP0003938_abnormal_ear_development0.66571157
120MP0002102_abnormal_ear_morphology0.66249279
121MP0002160_abnormal_reproductive_system0.66069226
122MP0005187_abnormal_penis_morphology0.66040000
123MP0000467_abnormal_esophagus_morphology0.66023815
124MP0000049_abnormal_middle_ear0.65117036
125MP0002925_abnormal_cardiovascular_devel0.64344010
126MP0002269_muscular_atrophy0.63633661
127MP0001919_abnormal_reproductive_system0.63504175
128MP0002114_abnormal_axial_skeleton0.63038153
129MP0003861_abnormal_nervous_system0.60496092
130* MP0002429_abnormal_blood_cell0.59588453
131MP0002938_white_spotting0.59144862
132MP0003448_altered_tumor_morphology0.58736593
133MP0002653_abnormal_ependyma_morphology0.58422576
134MP0000477_abnormal_intestine_morphology0.57684479
135MP0008770_decreased_survivor_rate0.57225488
136MP0003942_abnormal_urinary_system0.56934291
137MP0002116_abnormal_craniofacial_bone0.56675665

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.27070199
2Chromsome breakage (HP:0040012)4.20977669
3Birth length less than 3rd percentile (HP:0003561)3.45266757
4Meckel diverticulum (HP:0002245)3.32535889
5Patellar aplasia (HP:0006443)3.29456804
6Abnormality of chromosome stability (HP:0003220)3.23689514
7Increased nuchal translucency (HP:0010880)3.21269456
8Abnormality of the ileum (HP:0001549)3.16340820
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.15317413
10Aplasia/Hypoplasia of the patella (HP:0006498)3.10241802
11Cortical dysplasia (HP:0002539)3.09422598
12Selective tooth agenesis (HP:0001592)3.06053655
13Impulsivity (HP:0100710)3.04512384
14Duodenal stenosis (HP:0100867)2.97298477
15Small intestinal stenosis (HP:0012848)2.97298477
16Breast hypoplasia (HP:0003187)2.93530529
17Abnormality of the preputium (HP:0100587)2.92698953
18Ectopic kidney (HP:0000086)2.84405233
19Reticulocytopenia (HP:0001896)2.83775095
20Absent radius (HP:0003974)2.79343196
21Short 4th metacarpal (HP:0010044)2.72380707
22Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.72380707
23Progressive muscle weakness (HP:0003323)2.70410502
24Volvulus (HP:0002580)2.65837989
25Proximal placement of thumb (HP:0009623)2.65525541
26Deep philtrum (HP:0002002)2.64264751
27Deviation of the thumb (HP:0009603)2.63908873
28Absent forearm bone (HP:0003953)2.59859592
29Aplasia involving forearm bones (HP:0009822)2.59859592
30Progressive external ophthalmoplegia (HP:0000590)2.59785202
31Degeneration of anterior horn cells (HP:0002398)2.59358027
32Abnormality of the anterior horn cell (HP:0006802)2.59358027
33Carpal bone hypoplasia (HP:0001498)2.55247972
34Insomnia (HP:0100785)2.52841414
35Myelodysplasia (HP:0002863)2.50921709
36Colon cancer (HP:0003003)2.50892719
37Ependymoma (HP:0002888)2.46537269
38Abnormality of the duodenum (HP:0002246)2.45049277
39Medulloblastoma (HP:0002885)2.43641140
40Abnormality of the carotid arteries (HP:0005344)2.40670740
41Sloping forehead (HP:0000340)2.35770553
42Abnormal lung lobation (HP:0002101)2.35076042
43Abnormality of the calcaneus (HP:0008364)2.29380931
44Facial hemangioma (HP:0000329)2.27091007
45Atresia of the external auditory canal (HP:0000413)2.26433836
46Ankle contracture (HP:0006466)2.25684315
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24544898
48Abnormality of the labia minora (HP:0012880)2.23367074
49Neoplasm of the pancreas (HP:0002894)2.21706930
50Cafe-au-lait spot (HP:0000957)2.20388512
51Heterotopia (HP:0002282)2.19486551
52Absent thumb (HP:0009777)2.19206976
53Abnormality of the phalanges of the hallux (HP:0010057)2.17956221
5411 pairs of ribs (HP:0000878)2.15377382
55Asymmetry of the thorax (HP:0001555)2.13099955
56Termporal pattern (HP:0011008)2.12600331
57Insidious onset (HP:0003587)2.12600331
58Orthostatic hypotension (HP:0001278)2.12145694
59Abnormality of the umbilical cord (HP:0010881)2.12013689
60Tracheoesophageal fistula (HP:0002575)2.11665915
61Bone marrow hypocellularity (HP:0005528)2.11391069
62Rough bone trabeculation (HP:0100670)2.11281465
63Overriding aorta (HP:0002623)2.10803428
64Short thumb (HP:0009778)2.10394256
65Hypoplasia of the capital femoral epiphysis (HP:0003090)2.09804058
66High pitched voice (HP:0001620)2.08970463
67Rhabdomyosarcoma (HP:0002859)2.07989104
68Premature rupture of membranes (HP:0001788)2.07804934
69Abnormal number of incisors (HP:0011064)2.07663068
70Microglossia (HP:0000171)2.04867697
71Duplicated collecting system (HP:0000081)2.04138065
72Abnormality of the fetal cardiovascular system (HP:0010948)2.03797958
73Abnormal umbilical cord blood vessels (HP:0011403)2.03797958
74Single umbilical artery (HP:0001195)2.03797958
75Ankyloglossia (HP:0010296)2.03460158
76Nephroblastoma (Wilms tumor) (HP:0002667)2.01882740
77Triphalangeal thumb (HP:0001199)2.00587847
78Aplasia/Hypoplasia of the sternum (HP:0006714)1.98222527
79Overlapping toe (HP:0001845)1.97995044
80Abnormality of the distal phalanges of the toes (HP:0010182)1.97667310
81High anterior hairline (HP:0009890)1.96433837
82Oral leukoplakia (HP:0002745)1.95905396
83Horseshoe kidney (HP:0000085)1.94301607
84Prominent nose (HP:0000448)1.93946028
85Glioma (HP:0009733)1.93792128
86Renal duplication (HP:0000075)1.92939115
87Sensory axonal neuropathy (HP:0003390)1.90998962
88Agnosia (HP:0010524)1.90257244
89Leiomyosarcoma (HP:0100243)1.90010832
90Uterine leiomyosarcoma (HP:0002891)1.90010832
91Embryonal neoplasm (HP:0002898)1.89741512
92Slender long bone (HP:0003100)1.88684125
93Abnormality of the astrocytes (HP:0100707)1.88413796
94Astrocytoma (HP:0009592)1.88413796
95Embryonal renal neoplasm (HP:0011794)1.88367922
96Abnormality of glycolysis (HP:0004366)1.88180690
97Squamous cell carcinoma (HP:0002860)1.87394832
98Entropion (HP:0000621)1.86716375
99Poikiloderma (HP:0001029)1.86562825
100Oligodactyly (HP:0012165)1.86261278
101Abnormality of chromosome segregation (HP:0002916)1.85064241
102Multiple enchondromatosis (HP:0005701)1.84479630
103Premature graying of hair (HP:0002216)1.84307763
104Missing ribs (HP:0000921)1.84058905
105Duplication of thumb phalanx (HP:0009942)1.83932863
106Clubbing of toes (HP:0100760)1.83174152
107Ureteral duplication (HP:0000073)1.82139665
108Abnormality of oral frenula (HP:0000190)1.81695709
109Basal cell carcinoma (HP:0002671)1.81093556
110Microvesicular hepatic steatosis (HP:0001414)1.80042638
111Ulnar bowing (HP:0003031)1.79882737
112Elfin facies (HP:0004428)1.79454593
113Hyperacusis (HP:0010780)1.78353303
114Abnormality of the 4th metacarpal (HP:0010012)1.77865854
115Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.77081667
116Choanal atresia (HP:0000453)1.74868640
117Premature ovarian failure (HP:0008209)1.74792941
118Abnormality of the renal collecting system (HP:0004742)1.73935912
119Short middle phalanx of the 5th finger (HP:0004220)1.73330150
120Pelvic girdle muscle weakness (HP:0003749)1.73047506
121Broad distal phalanx of finger (HP:0009836)1.73000368
122Ragged-red muscle fibers (HP:0003200)1.72768116
123Small epiphyses (HP:0010585)1.72654333
124Vertebral arch anomaly (HP:0008438)1.72573219
125Sparse lateral eyebrow (HP:0005338)1.70744568
126Aplasia/Hypoplasia of the earlobes (HP:0009906)1.70382460
127Gastrointestinal carcinoma (HP:0002672)1.69954019
128Malignant gastrointestinal tract tumors (HP:0006749)1.69954019
129Arteriovenous malformation (HP:0100026)1.69435623
130Sandal gap (HP:0001852)1.69026356
131Osteolytic defects of the phalanges of the hand (HP:0009771)1.68802638
132Osteolytic defects of the hand bones (HP:0009699)1.68802638
133Abnormality of the distal phalanx of the thumb (HP:0009617)1.67731888
134Septate vagina (HP:0001153)1.67663179
135Shoulder girdle muscle weakness (HP:0003547)1.67026359
136Short nail (HP:0001799)1.66856564
137Wrist flexion contracture (HP:0001239)1.66567816
138Aplastic anemia (HP:0001915)1.65608940
139Shallow orbits (HP:0000586)1.64231265
140Trismus (HP:0000211)1.63949819
141Progressive hearing impairment (HP:0001730)1.63351349
142Abnormal foot bone ossification (HP:0010675)1.62668563
143Absent epiphyses (HP:0010577)1.62308518
144Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.62308518
145Spinal cord lesions (HP:0100561)1.61995367
146Abnormality of abdominal situs (HP:0011620)1.61448547
147Abdominal situs inversus (HP:0003363)1.61448547
148Aplasia/hypoplasia of the humerus (HP:0006507)1.61367101
149Broad palm (HP:0001169)1.61272440
150Cutaneous melanoma (HP:0012056)1.60972290
151Long eyelashes (HP:0000527)1.60488902
152Supernumerary spleens (HP:0009799)1.59246963
153Neoplasm of the colon (HP:0100273)1.58663331

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.59254690
2CDC74.38392816
3WEE13.87496134
4NEK23.81215036
5TTK2.77038916
6BRSK22.76409539
7BRSK12.63811811
8* PLK12.21160360
9NEK12.08634167
10CDK122.04840442
11STK102.03571987
12EEF2K2.00363757
13* AURKB1.95068843
14MST1R1.93595748
15SMG11.93487453
16PLK41.91960151
17TESK21.88000432
18SRPK11.83864104
19EIF2AK11.82441188
20PLK31.65115944
21CHEK21.62626401
22ATR1.61041148
23AURKA1.60686659
24CDK41.58886172
25MELK1.56922835
26CCNB11.56350923
27PASK1.55851331
28MAP3K81.54299117
29ICK1.52526397
30CDK71.51211750
31ACVR1B1.48200270
32MKNK11.47504089
33DYRK31.45767933
34RPS6KA41.44366224
35MAP3K101.42340452
36STK41.39936016
37TLK11.36078737
38PKN21.33193256
39RPS6KB21.32677713
40TRIB31.30481062
41MET1.29626433
42TSSK61.29571508
43* CHEK11.20294600
44MST41.19699279
45ZAK1.19212774
46VRK21.17685731
47MKNK21.16764973
48IRAK31.13461658
49PAK41.09400029
50STK31.09164087
51VRK11.08817978
52TAF10.99795515
53CDK60.99127896
54NME20.98373167
55BRD40.98312635
56EPHA20.95175247
57SCYL20.90796677
58ATM0.87546132
59CDK20.85418994
60ERBB40.79196640
61TESK10.79099251
62LATS10.77832657
63EIF2AK30.76240764
64CDK10.75107672
65TTN0.72910573
66PAK10.72723479
67TGFBR10.71041079
68CLK10.70310919
69PRPF4B0.70295037
70PTK20.69373484
71LRRK20.68345030
72CDK80.67417773
73LATS20.67110267
74ALK0.65481143
75PIM10.62121625
76MTOR0.56648586
77KSR20.54919259
78EIF2AK20.54624798
79STK38L0.54513498
80MARK30.53797357
81MAPK110.50847706
82MAP4K10.50343527
83CDK140.49601718
84SIK10.48948686
85BMX0.48866207
86CSNK2A10.41872411
87CDK90.41558292
88RAF10.40274753
89MAP3K90.40194264
90FGFR10.39786627
91KSR10.38215020
92CSNK2A20.37579224
93UHMK10.36081959
94DYRK1B0.34586502
95PAK20.34375050
96RPS6KA50.33812523
97PRKDC0.32260229
98PRKCI0.32176024
99MAPKAPK20.31564599
100NEK90.31361562
101PBK0.29982279
102LIMK10.29822377
103* AKT20.28777959
104ARAF0.28288949
105ILK0.27263184
106MAPK140.26770589
107NEK60.26371029
108TAOK20.24955178
109STK160.24207202
110BRAF0.24163944
111CDK11A0.23975567
112CDK150.23106526
113PNCK0.22505852
114AKT10.22286479
115FLT30.21692379
116CDK180.21341938
117PTK60.21059366
118CDC42BPA0.21034785
119PDGFRA0.20909991
120CSNK1E0.18300203
121RPS6KA10.17817650

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.72462746
2Mismatch repair_Homo sapiens_hsa034303.86663012
3Cell cycle_Homo sapiens_hsa041103.67579124
4Base excision repair_Homo sapiens_hsa034103.19433485
5RNA transport_Homo sapiens_hsa030133.13416973
6Spliceosome_Homo sapiens_hsa030403.12061102
7Homologous recombination_Homo sapiens_hsa034402.99441463
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.99144875
9Nucleotide excision repair_Homo sapiens_hsa034202.56760609
10Fanconi anemia pathway_Homo sapiens_hsa034602.51675675
11RNA polymerase_Homo sapiens_hsa030202.39887473
12One carbon pool by folate_Homo sapiens_hsa006702.34857530
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09908832
14p53 signaling pathway_Homo sapiens_hsa041152.03331883
15mRNA surveillance pathway_Homo sapiens_hsa030151.97038729
16Pyrimidine metabolism_Homo sapiens_hsa002401.96959351
17Non-homologous end-joining_Homo sapiens_hsa034501.90267355
18Proteasome_Homo sapiens_hsa030501.86862119
19Ribosome_Homo sapiens_hsa030101.85486794
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68483946
21RNA degradation_Homo sapiens_hsa030181.66750348
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.66634967
23Systemic lupus erythematosus_Homo sapiens_hsa053221.59920725
24Basal transcription factors_Homo sapiens_hsa030221.59470482
25Oocyte meiosis_Homo sapiens_hsa041141.50359100
26Viral carcinogenesis_Homo sapiens_hsa052031.41102946
27Epstein-Barr virus infection_Homo sapiens_hsa051691.31376365
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30951616
29MicroRNAs in cancer_Homo sapiens_hsa052061.26846557
30HTLV-I infection_Homo sapiens_hsa051661.16659917
31Carbon metabolism_Homo sapiens_hsa012001.10138275
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08082851
33Small cell lung cancer_Homo sapiens_hsa052221.07798565
34Vitamin B6 metabolism_Homo sapiens_hsa007501.05690031
35Herpes simplex infection_Homo sapiens_hsa051681.03953057
36Antigen processing and presentation_Homo sapiens_hsa046120.96875669
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96697810
38Purine metabolism_Homo sapiens_hsa002300.95468346
39Pyruvate metabolism_Homo sapiens_hsa006200.90303505
40Hippo signaling pathway_Homo sapiens_hsa043900.84561575
41Colorectal cancer_Homo sapiens_hsa052100.83741772
42Chronic myeloid leukemia_Homo sapiens_hsa052200.82893253
43Basal cell carcinoma_Homo sapiens_hsa052170.81039784
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79747435
45Notch signaling pathway_Homo sapiens_hsa043300.79024108
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78174069
47Adherens junction_Homo sapiens_hsa045200.77058636
48Alcoholism_Homo sapiens_hsa050340.76749610
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73765531
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73060891
51Hepatitis B_Homo sapiens_hsa051610.71319071
52Bladder cancer_Homo sapiens_hsa052190.71269491
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70626727
54Apoptosis_Homo sapiens_hsa042100.70501331
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68469976
56Thyroid cancer_Homo sapiens_hsa052160.68257982
57Viral myocarditis_Homo sapiens_hsa054160.66498906
58Glioma_Homo sapiens_hsa052140.65306650
59TGF-beta signaling pathway_Homo sapiens_hsa043500.65114847
60Pentose phosphate pathway_Homo sapiens_hsa000300.62873628
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62112600
62Sulfur relay system_Homo sapiens_hsa041220.60101542
63Shigellosis_Homo sapiens_hsa051310.58821710
64Renal cell carcinoma_Homo sapiens_hsa052110.58067472
65Pancreatic cancer_Homo sapiens_hsa052120.57762763
66Hedgehog signaling pathway_Homo sapiens_hsa043400.56317158
67Primary immunodeficiency_Homo sapiens_hsa053400.54008632
68Legionellosis_Homo sapiens_hsa051340.53597616
69Prostate cancer_Homo sapiens_hsa052150.52772450
70mTOR signaling pathway_Homo sapiens_hsa041500.52714288
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51547753
72Biosynthesis of amino acids_Homo sapiens_hsa012300.51187688
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51056150
74Measles_Homo sapiens_hsa051620.50278118
75ErbB signaling pathway_Homo sapiens_hsa040120.50216365
76Pathways in cancer_Homo sapiens_hsa052000.49961724
77Non-small cell lung cancer_Homo sapiens_hsa052230.49868504
78Fructose and mannose metabolism_Homo sapiens_hsa000510.48732330
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48216965
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47362142
81Proteoglycans in cancer_Homo sapiens_hsa052050.47199790
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46788831
83FoxO signaling pathway_Homo sapiens_hsa040680.45845383
84Steroid biosynthesis_Homo sapiens_hsa001000.45453011
85Selenocompound metabolism_Homo sapiens_hsa004500.44744758
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44331865
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.44159399
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.41157912
89Endometrial cancer_Homo sapiens_hsa052130.41154420
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.40288498
91AMPK signaling pathway_Homo sapiens_hsa041520.39593381
92Galactose metabolism_Homo sapiens_hsa000520.38552068
93N-Glycan biosynthesis_Homo sapiens_hsa005100.37819752
94HIF-1 signaling pathway_Homo sapiens_hsa040660.36344643
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36247931
96Glutathione metabolism_Homo sapiens_hsa004800.35147397
97Influenza A_Homo sapiens_hsa051640.35079926
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.34155990
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34149460
100Lysine degradation_Homo sapiens_hsa003100.33559480
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33509352
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33407909
103Tight junction_Homo sapiens_hsa045300.33139050
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.31590394
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31439429
106Wnt signaling pathway_Homo sapiens_hsa043100.31400695
107Insulin signaling pathway_Homo sapiens_hsa049100.30134688
108Melanoma_Homo sapiens_hsa052180.28460264
109Focal adhesion_Homo sapiens_hsa045100.28270482
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.28161772
111Fatty acid elongation_Homo sapiens_hsa000620.27005918
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.26735610
113Acute myeloid leukemia_Homo sapiens_hsa052210.26035281
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25550553
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25479268
116Gap junction_Homo sapiens_hsa045400.25375990
117Inositol phosphate metabolism_Homo sapiens_hsa005620.25048565
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24223300
119T cell receptor signaling pathway_Homo sapiens_hsa046600.24195602
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24188072
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23846282
122Folate biosynthesis_Homo sapiens_hsa007900.23078718
123B cell receptor signaling pathway_Homo sapiens_hsa046620.21075317
124Leishmaniasis_Homo sapiens_hsa051400.20373643
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.20001244
126Hematopoietic cell lineage_Homo sapiens_hsa046400.18121896
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.17052503

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