RAD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1post-embryonic morphogenesis (GO:0009886)5.92778107
2detection of molecule of bacterial origin (GO:0032490)5.79856995
3auditory receptor cell stereocilium organization (GO:0060088)5.55932451
4negative regulation of macroautophagy (GO:0016242)5.49937767
5energy homeostasis (GO:0097009)5.04232278
6positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.91142192
7sulfate transmembrane transport (GO:1902358)4.48398855
8sulfate transport (GO:0008272)4.15914346
9cellular anion homeostasis (GO:0030002)4.03099449
10inner ear receptor stereocilium organization (GO:0060122)3.99200463
11lateral ventricle development (GO:0021670)3.82583862
12detection of external biotic stimulus (GO:0098581)3.79363512
13protein localization to kinetochore (GO:0034501)3.73687216
14phosphate ion homeostasis (GO:0055062)3.68573744
15trivalent inorganic anion homeostasis (GO:0072506)3.68573744
16regulation of centriole replication (GO:0046599)3.58895964
17pseudouridine synthesis (GO:0001522)3.47961422
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.46145780
19cullin deneddylation (GO:0010388)3.41678634
20somatic hypermutation of immunoglobulin genes (GO:0016446)3.40536177
21somatic diversification of immune receptors via somatic mutation (GO:0002566)3.40536177
22establishment of integrated proviral latency (GO:0075713)3.32762133
23protein deneddylation (GO:0000338)3.22517043
24mitotic sister chromatid segregation (GO:0000070)3.21933158
25tRNA methylation (GO:0030488)3.21698548
26positive regulation of uterine smooth muscle contraction (GO:0070474)3.20799467
27DNA replication-dependent nucleosome organization (GO:0034723)3.19828137
28DNA replication-dependent nucleosome assembly (GO:0006335)3.19828137
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17270009
30CENP-A containing nucleosome assembly (GO:0034080)3.16942700
31DNA strand renaturation (GO:0000733)3.16391449
32nucleobase biosynthetic process (GO:0046112)3.16330333
33detection of biotic stimulus (GO:0009595)3.12130857
34chromatin remodeling at centromere (GO:0031055)3.12130564
35glycoside metabolic process (GO:0016137)3.12068183
36regulation of nuclear cell cycle DNA replication (GO:0033262)3.10848394
37protein localization to chromosome, centromeric region (GO:0071459)3.09786239
38purine nucleobase biosynthetic process (GO:0009113)3.09441020
39regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08621877
40regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.06841083
41regulation of mitotic spindle checkpoint (GO:1903504)3.06841083
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.06522043
43proteasome assembly (GO:0043248)3.05901238
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.05272164
45termination of RNA polymerase III transcription (GO:0006386)3.04418247
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.04418247
47regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.03055058
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.03041554
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.03041554
50NADH dehydrogenase complex assembly (GO:0010257)3.03041554
51sister chromatid segregation (GO:0000819)3.01634472
52mitochondrial RNA metabolic process (GO:0000959)3.00623840
53mitochondrial respiratory chain complex assembly (GO:0033108)3.00295507
54respiratory chain complex IV assembly (GO:0008535)2.99732878
55postreplication repair (GO:0006301)2.96779226
56energy coupled proton transport, down electrochemical gradient (GO:0015985)2.96231599
57ATP synthesis coupled proton transport (GO:0015986)2.96231599
58DNA deamination (GO:0045006)2.95499025
59DNA replication initiation (GO:0006270)2.94834399
60positive regulation of protein sumoylation (GO:0033235)2.94797763
61regulation of interleukin-6 biosynthetic process (GO:0045408)2.93720642
62telomere maintenance via semi-conservative replication (GO:0032201)2.93605649
63protein complex biogenesis (GO:0070271)2.92960324
64kinetochore assembly (GO:0051382)2.92905995
65spliceosomal snRNP assembly (GO:0000387)2.92681252
66positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.90630236
67centriole assembly (GO:0098534)2.90532362
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.88904273
69negative regulation of ligase activity (GO:0051352)2.88904273
70recombinational repair (GO:0000725)2.88354542
71regulation of centrosome cycle (GO:0046605)2.87540599
72spindle checkpoint (GO:0031577)2.86780895
73double-strand break repair via homologous recombination (GO:0000724)2.85142252
74kinetochore organization (GO:0051383)2.84002092
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.83972004
76replicative senescence (GO:0090399)2.82235925
77negative regulation of response to nutrient levels (GO:0032108)2.82034501
78negative regulation of response to extracellular stimulus (GO:0032105)2.82034501
79meiotic chromosome segregation (GO:0045132)2.80983520
80ribosome assembly (GO:0042255)2.80643778
81DNA-dependent DNA replication (GO:0006261)2.79007707
82negative regulation of DNA-dependent DNA replication (GO:2000104)2.78094419
83mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.78054625
84* DNA catabolic process, exonucleolytic (GO:0000738)2.77851295
85water-soluble vitamin biosynthetic process (GO:0042364)2.75723609
86DNA integration (GO:0015074)2.75399091
87mitotic spindle checkpoint (GO:0071174)2.75320502
88DNA replication checkpoint (GO:0000076)2.75025308
89chaperone-mediated protein transport (GO:0072321)2.72327702
90negative regulation of chromosome segregation (GO:0051985)2.72313038
91rRNA modification (GO:0000154)2.71845328
92synapsis (GO:0007129)2.71813728
93termination of RNA polymerase I transcription (GO:0006363)2.71806025
94protein neddylation (GO:0045116)2.71600966
95estrogen biosynthetic process (GO:0006703)2.71183089
96tRNA processing (GO:0008033)2.71050271
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.70693695
98protein-cofactor linkage (GO:0018065)2.69432823
99protein K6-linked ubiquitination (GO:0085020)2.69339770
100DNA damage response, detection of DNA damage (GO:0042769)2.69197663
101negative regulation of mitotic sister chromatid separation (GO:2000816)2.68892897
102negative regulation of sister chromatid segregation (GO:0033046)2.68892897
103negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.68892897
104negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.68892897
105negative regulation of mitotic sister chromatid segregation (GO:0033048)2.68892897
106establishment of protein localization to mitochondrial membrane (GO:0090151)2.68400030
107regulation of helicase activity (GO:0051095)2.68078715
108nuclear pore complex assembly (GO:0051292)2.67525212
109histone H3-K9 modification (GO:0061647)2.66975561
110positive regulation of neurological system process (GO:0031646)2.65809994
111nuclear pore organization (GO:0006999)2.65336902
112telomere maintenance via recombination (GO:0000722)2.64537425
113DNA strand elongation involved in DNA replication (GO:0006271)2.63968289
114tRNA metabolic process (GO:0006399)2.63607740
115double-strand break repair via nonhomologous end joining (GO:0006303)2.63498172
116non-recombinational repair (GO:0000726)2.63498172
117positive regulation of neurotransmitter secretion (GO:0001956)2.59244487
118regulation of double-strand break repair via homologous recombination (GO:0010569)2.58459304
119DNA strand elongation (GO:0022616)2.57704811
120mitotic metaphase plate congression (GO:0007080)2.57679985
121mismatch repair (GO:0006298)2.56784502
122regulation of DNA endoreduplication (GO:0032875)2.55960555
123sulfur compound transport (GO:0072348)2.55711191
124pyrimidine dimer repair (GO:0006290)2.53272347
125maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.53013585
126transcription elongation from RNA polymerase I promoter (GO:0006362)2.52910832
127telomere maintenance via telomere lengthening (GO:0010833)2.52898072
128deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.50774785
129rRNA methylation (GO:0031167)2.49728373
130positive regulation of DNA-dependent DNA replication (GO:2000105)2.48433240
131inositol metabolic process (GO:0006020)2.47375166
132DNA replication-independent nucleosome organization (GO:0034724)2.46485447
133DNA replication-independent nucleosome assembly (GO:0006336)2.46485447
134regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.45597296
135mitotic recombination (GO:0006312)2.43165074
136histone H2A acetylation (GO:0043968)2.41843421
137bicarbonate transport (GO:0015701)2.41420110
138histone exchange (GO:0043486)2.39096641
139regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.34843440
140transcription from RNA polymerase I promoter (GO:0006360)2.33906435
141maturation of 5.8S rRNA (GO:0000460)2.31170968
142tRNA modification (GO:0006400)2.30506150
143maintenance of gastrointestinal epithelium (GO:0030277)2.30214259
144mesenchymal cell differentiation involved in kidney development (GO:0072161)2.28843949
145mesenchymal cell differentiation involved in renal system development (GO:2001012)2.28843949
146deoxyribonucleotide biosynthetic process (GO:0009263)2.28090746
147replication fork processing (GO:0031297)2.28048890
148eye photoreceptor cell development (GO:0042462)2.27992995
149transcription initiation from RNA polymerase I promoter (GO:0006361)2.26866224
150DNA synthesis involved in DNA repair (GO:0000731)2.26552914
151metaphase plate congression (GO:0051310)2.26424467
152exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.25395636
153DNA double-strand break processing (GO:0000729)2.25366155
154ribosome biogenesis (GO:0042254)2.25249579
155regulation of uterine smooth muscle contraction (GO:0070472)2.25012121
156modulation by virus of host process (GO:0019054)2.23830045
157pore complex assembly (GO:0046931)2.23491564
158IMP biosynthetic process (GO:0006188)2.22410906
159negative regulation of mast cell activation (GO:0033004)2.21139924
160paraxial mesoderm development (GO:0048339)2.20547806
161nucleotide-excision repair, DNA gap filling (GO:0006297)2.20493596
162transcription-coupled nucleotide-excision repair (GO:0006283)2.19649943
163polyketide metabolic process (GO:0030638)17.3408784
164doxorubicin metabolic process (GO:0044598)17.3408784
165daunorubicin metabolic process (GO:0044597)17.3408784
166aminoglycoside antibiotic metabolic process (GO:0030647)11.1370402

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.76253960
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.06811121
3FOXM1_23109430_ChIP-Seq_U2OS_Human2.88001314
4CREB1_15753290_ChIP-ChIP_HEK293T_Human2.87141766
5EZH2_22144423_ChIP-Seq_EOC_Human2.66449257
6GBX2_23144817_ChIP-Seq_PC3_Human2.64813847
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.62341305
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.55155119
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.54633099
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.54146314
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.52139495
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.51855457
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.46699502
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.40533999
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30651687
16PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22958527
17POU5F1_16153702_ChIP-ChIP_HESCs_Human2.14619184
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.14420049
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12067448
20SUZ12_27294783_Chip-Seq_NPCs_Mouse2.08005321
21NFE2_27457419_Chip-Seq_LIVER_Mouse2.06686481
22ZNF274_21170338_ChIP-Seq_K562_Hela2.06494024
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05759185
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.05756384
25PADI4_21655091_ChIP-ChIP_MCF-7_Human1.99361603
26* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94984998
27DCP1A_22483619_ChIP-Seq_HELA_Human1.94894018
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.92707124
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.92625982
30VDR_22108803_ChIP-Seq_LS180_Human1.87880873
31IRF1_19129219_ChIP-ChIP_H3396_Human1.81090883
32* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81041895
33AR_21909140_ChIP-Seq_LNCAP_Human1.78587500
34* GABP_17652178_ChIP-ChIP_JURKAT_Human1.74486169
35XRN2_22483619_ChIP-Seq_HELA_Human1.68283941
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68265968
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66707263
38EWS_26573619_Chip-Seq_HEK293_Human1.66540222
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.62214732
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58373752
41* GABP_19822575_ChIP-Seq_HepG2_Human1.56757864
42* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53910807
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.53563265
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.53563265
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.53563265
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52375281
47* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51002591
48* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48586921
49* VDR_23849224_ChIP-Seq_CD4+_Human1.48378804
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47460507
51* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47078127
52FOXP3_21729870_ChIP-Seq_TREG_Human1.46678047
53* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44271181
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.44048611
55NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.42539598
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38400201
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37332873
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.36266927
59SUZ12_18555785_Chip-Seq_ESCs_Mouse1.35212577
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.35093316
61* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35053560
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35028325
63* ETS1_20019798_ChIP-Seq_JURKAT_Human1.34481719
64NMYC_18555785_Chip-Seq_ESCs_Mouse1.33826669
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32554567
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30340194
67STAT3_18555785_Chip-Seq_ESCs_Mouse1.29964417
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27592312
69P53_22387025_ChIP-Seq_ESCs_Mouse1.27240407
70RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26438393
71* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25798649
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25208001
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24904388
74OCT4_18555785_Chip-Seq_ESCs_Mouse1.24854733
75RNF2_27304074_Chip-Seq_NSC_Mouse1.24562535
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.24064209
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23356127
78RUNX1_27457419_Chip-Seq_LIVER_Mouse1.22928206
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21736582
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20484956
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.20409950
82* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19939102
83ZFX_18555785_Chip-Seq_ESCs_Mouse1.19920352
84EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19914404
85KDM5A_27292631_Chip-Seq_BREAST_Human1.17306279
86FUS_26573619_Chip-Seq_HEK293_Human1.15866131
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15487825
88HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15424869
89P300_18555785_Chip-Seq_ESCs_Mouse1.15043866
90NANOG_16153702_ChIP-ChIP_HESCs_Human1.14414901
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14066616
92KLF4_18555785_Chip-Seq_ESCs_Mouse1.13480643
93SOX2_16153702_ChIP-ChIP_HESCs_Human1.13324442
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12822321
95TAF15_26573619_Chip-Seq_HEK293_Human1.12408020
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11824476
97CMYC_18555785_Chip-Seq_ESCs_Mouse1.10146379
98SOX2_18555785_Chip-Seq_ESCs_Mouse1.09909242
99TTF2_22483619_ChIP-Seq_HELA_Human1.09612120
100P300_19829295_ChIP-Seq_ESCs_Human1.08582411
101ESRRB_18555785_Chip-Seq_ESCs_Mouse1.07898270
102ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05644856
103MYC_18940864_ChIP-ChIP_HL60_Human1.05574943
104E2F1_21310950_ChIP-Seq_MCF-7_Human1.05347778
105SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.05111198
106CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03498530
107PU1_27457419_Chip-Seq_LIVER_Mouse1.03052456
108NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02515555
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02187331
110ELK1_19687146_ChIP-ChIP_HELA_Human1.00587205
111KAP1_22055183_ChIP-Seq_ESCs_Mouse1.00403972
112POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00363986
113CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99343909
114CBX2_27304074_Chip-Seq_ESCs_Mouse0.99310256
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96769374
116MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96365256
117CTCF_18555785_Chip-Seq_ESCs_Mouse0.95429125
118E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95236276
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95036333
120OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94870835
121HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94561741
122CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94411632
123SMAD1_18555785_Chip-Seq_ESCs_Mouse0.94391046
124CRX_20693478_ChIP-Seq_RETINA_Mouse0.93895763
125CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93451561
126SALL1_21062744_ChIP-ChIP_HESCs_Human0.93234529
127TP53_22573176_ChIP-Seq_HFKS_Human0.92821353
128ELK1_22589737_ChIP-Seq_MCF10A_Human0.92421286
129IGF1R_20145208_ChIP-Seq_DFB_Human0.92366988
130SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91324164
131RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89471873
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87865446
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.87324294
134DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83803031
135SOX17_20123909_ChIP-Seq_XEN_Mouse0.80293991
136* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.79717434
137PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79701434
138HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77760675
139RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77400992
140CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.76872065
141CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.74670297
142BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.74302605
143GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.73989190
144SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73361092
145ER_23166858_ChIP-Seq_MCF-7_Human0.70225833

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology6.03410865
2MP0005377_hearing/vestibular/ear_phenot6.03410865
3MP0008004_abnormal_stomach_pH4.77805578
4MP0006292_abnormal_olfactory_placode3.75278552
5MP0005645_abnormal_hypothalamus_physiol3.65261506
6MP0009697_abnormal_copulation2.99160368
7MP0000678_abnormal_parathyroid_gland2.84049559
8MP0010094_abnormal_chromosome_stability2.80778943
9MP0003941_abnormal_skin_development2.75743881
10MP0008058_abnormal_DNA_repair2.75235562
11MP0000566_synostosis2.74633532
12MP0003693_abnormal_embryo_hatching2.73037998
13MP0001986_abnormal_taste_sensitivity2.71982274
14MP0003879_abnormal_hair_cell2.68000851
15MP0003111_abnormal_nucleus_morphology2.61606951
16MP0001485_abnormal_pinna_reflex2.41801008
17MP0008057_abnormal_DNA_replication2.38303088
18MP0006072_abnormal_retinal_apoptosis2.20190177
19MP0003077_abnormal_cell_cycle2.05809299
20MP0002132_abnormal_respiratory_system1.97525305
21MP0004147_increased_porphyrin_level1.91755920
22MP0004742_abnormal_vestibular_system1.87187524
23MP0005423_abnormal_somatic_nervous1.85964358
24MP0002102_abnormal_ear_morphology1.83298263
25MP0004957_abnormal_blastocyst_morpholog1.79292387
26MP0001188_hyperpigmentation1.75106012
27MP0002638_abnormal_pupillary_reflex1.66308165
28MP0002277_abnormal_respiratory_mucosa1.63352899
29MP0002837_dystrophic_cardiac_calcinosis1.57158047
30MP0000372_irregular_coat_pigmentation1.52019593
31MP0005253_abnormal_eye_physiology1.47175112
32MP0002938_white_spotting1.46643352
33MP0006035_abnormal_mitochondrial_morpho1.44700473
34MP0006276_abnormal_autonomic_nervous1.43677685
35MP0002396_abnormal_hematopoietic_system1.42809279
36MP0003786_premature_aging1.42033526
37MP0008007_abnormal_cellular_replicative1.38545603
38MP0005646_abnormal_pituitary_gland1.37286743
39MP0003567_abnormal_fetal_cardiomyocyte1.32248034
40MP0003718_maternal_effect1.32074472
41MP0002163_abnormal_gland_morphology1.30552908
42MP0003806_abnormal_nucleotide_metabolis1.29993692
43MP0008877_abnormal_DNA_methylation1.24980270
44MP0008789_abnormal_olfactory_epithelium1.23859664
45MP0005551_abnormal_eye_electrophysiolog1.21896094
46MP0008932_abnormal_embryonic_tissue1.16905424
47MP0001293_anophthalmia1.14933734
48MP0005389_reproductive_system_phenotype1.13733220
49MP0006036_abnormal_mitochondrial_physio1.13598308
50MP0003119_abnormal_digestive_system1.13566224
51MP0002234_abnormal_pharynx_morphology1.12750685
52MP0003186_abnormal_redox_activity1.12491275
53MP0010030_abnormal_orbit_morphology1.12355985
54MP0003646_muscle_fatigue1.12211402
55MP0005379_endocrine/exocrine_gland_phen1.11539761
56MP0000647_abnormal_sebaceous_gland1.10695839
57MP0001697_abnormal_embryo_size1.10070541
58MP0002210_abnormal_sex_determination1.09631858
59MP0005171_absent_coat_pigmentation1.08417344
60MP0000470_abnormal_stomach_morphology1.06763012
61MP0002160_abnormal_reproductive_system1.06234212
62MP0001529_abnormal_vocalization1.05655746
63MP0002084_abnormal_developmental_patter1.05073947
64MP0001486_abnormal_startle_reflex1.03487612
65MP0003136_yellow_coat_color1.02295742
66MP0001984_abnormal_olfaction1.01008433
67MP0005391_vision/eye_phenotype1.00878620
68MP0001119_abnormal_female_reproductive0.98548484
69MP0000358_abnormal_cell_content/0.96662291
70MP0005187_abnormal_penis_morphology0.96403573
71MP0001672_abnormal_embryogenesis/_devel0.96336602
72MP0005380_embryogenesis_phenotype0.96336602
73MP0004142_abnormal_muscle_tone0.95844267
74MP0001730_embryonic_growth_arrest0.95060346
75MP0010307_abnormal_tumor_latency0.93524830
76MP0002697_abnormal_eye_size0.92337081
77MP0003938_abnormal_ear_development0.90749268
78MP0001919_abnormal_reproductive_system0.89354390
79MP0004133_heterotaxia0.87902566
80MP0000026_abnormal_inner_ear0.87835787
81MP0003890_abnormal_embryonic-extraembry0.87207818
82MP0005647_abnormal_sex_gland0.87193446
83MP0002098_abnormal_vibrissa_morphology0.87183752
84MP0000490_abnormal_crypts_of0.87023327
85MP0010386_abnormal_urinary_bladder0.85173231
86MP0001186_pigmentation_phenotype0.84007181
87MP0004215_abnormal_myocardial_fiber0.83996329
88MP0002249_abnormal_larynx_morphology0.83082525
89MP0004197_abnormal_fetal_growth/weight/0.83078518
90MP0002111_abnormal_tail_morphology0.82982208
91MP0008995_early_reproductive_senescence0.81895918
92MP0002735_abnormal_chemical_nociception0.81781374
93MP0001963_abnormal_hearing_physiology0.81734988
94MP0009046_muscle_twitch0.81030969
95MP0002095_abnormal_skin_pigmentation0.80888864
96MP0005084_abnormal_gallbladder_morpholo0.80645732
97MP0003936_abnormal_reproductive_system0.80524539
98MP0003755_abnormal_palate_morphology0.78925528
99MP0000681_abnormal_thyroid_gland0.78543412
100MP0002088_abnormal_embryonic_growth/wei0.78055806
101MP0002080_prenatal_lethality0.77603020
102MP0003984_embryonic_growth_retardation0.77525071
103MP0003787_abnormal_imprinting0.77051289
104MP0002075_abnormal_coat/hair_pigmentati0.77035134
105MP0003937_abnormal_limbs/digits/tail_de0.76406198
106MP0002751_abnormal_autonomic_nervous0.76032081
107MP0000631_abnormal_neuroendocrine_gland0.75408638
108MP0001324_abnormal_eye_pigmentation0.75272611
109MP0002557_abnormal_social/conspecific_i0.74940262
110MP0000516_abnormal_urinary_system0.74539880
111MP0005367_renal/urinary_system_phenotyp0.74539880
112MP0000653_abnormal_sex_gland0.73985422
113MP0003763_abnormal_thymus_physiology0.73649488
114MP0003137_abnormal_impulse_conducting0.72924573
115MP0003315_abnormal_perineum_morphology0.71193690
116MP0002184_abnormal_innervation0.70456047
117MP0008872_abnormal_physiological_respon0.70443011
118MP0003861_abnormal_nervous_system0.70412258
119MP0009672_abnormal_birth_weight0.70329603
120MP0002090_abnormal_vision0.70226414
121MP0000613_abnormal_salivary_gland0.70179764
122MP0005195_abnormal_posterior_eye0.69516106
123MP0000579_abnormal_nail_morphology0.69261116
124MP0005075_abnormal_melanosome_morpholog0.69066337
125MP0004381_abnormal_hair_follicle0.68940896
126MP0003950_abnormal_plasma_membrane0.68474421
127MP0001664_abnormal_digestion0.67787568
128MP0001145_abnormal_male_reproductive0.66993985
129MP0000049_abnormal_middle_ear0.64660355
130MP0001764_abnormal_homeostasis0.63947393
131MP0000350_abnormal_cell_proliferation0.61853232
132MP0001286_abnormal_eye_development0.61748466
133MP0005501_abnormal_skin_physiology0.61385318
134MP0003698_abnormal_male_reproductive0.60148530
135MP0000383_abnormal_hair_follicle0.58794866
136MP0000313_abnormal_cell_death0.57680578
137MP0001929_abnormal_gametogenesis0.55411260
138MP0000015_abnormal_ear_pigmentation0.54890891
139MP0002127_abnormal_cardiovascular_syste0.54210448
140MP0002233_abnormal_nose_morphology0.53397981
141MP0000427_abnormal_hair_cycle0.53207117
142MP0004782_abnormal_surfactant_physiolog0.53023596
143MP0005310_abnormal_salivary_gland0.52146983
144MP0002085_abnormal_embryonic_tissue0.50491917
145MP0003121_genomic_imprinting0.49782366
146MP0001968_abnormal_touch/_nociception0.49367497
147MP0002736_abnormal_nociception_after0.48636321
148MP0001346_abnormal_lacrimal_gland0.48057815

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)7.37647193
2Unilateral renal agenesis (HP:0000122)6.34353323
3Chromosomal breakage induced by crosslinking agents (HP:0003221)5.74934124
4Alopecia of scalp (HP:0002293)5.30256420
5Chromsome breakage (HP:0040012)5.23615745
6Abnormality of dental color (HP:0011073)5.03686034
7Bilateral sensorineural hearing impairment (HP:0008619)4.93315752
8Absent eyebrow (HP:0002223)4.87520220
9Follicular hyperkeratosis (HP:0007502)4.47418149
10Absent eyelashes (HP:0000561)4.44237247
11Dynein arm defect of respiratory motile cilia (HP:0012255)4.11756999
12Absent/shortened dynein arms (HP:0200106)4.11756999
13Cheilitis (HP:0100825)4.07569898
14Duplicated collecting system (HP:0000081)4.05231402
15Abnormality of the renal collecting system (HP:0004742)3.85848197
16Recurrent corneal erosions (HP:0000495)3.62934232
17Chronic otitis media (HP:0000389)3.39296270
18Abnormality of the preputium (HP:0100587)3.26399137
19Acute necrotizing encephalopathy (HP:0006965)3.19223450
20Ectopic kidney (HP:0000086)3.16432440
21Aplasia/Hypoplasia of the uvula (HP:0010293)3.09652530
22Abnormal mitochondria in muscle tissue (HP:0008316)3.01814832
23Reticulocytopenia (HP:0001896)3.01308595
24Erythroderma (HP:0001019)2.99981890
25Abnormal respiratory motile cilium morphology (HP:0005938)2.97717637
26Abnormal respiratory epithelium morphology (HP:0012253)2.97717637
27Meckel diverticulum (HP:0002245)2.96341608
28Ectropion (HP:0000656)2.95262157
29Abnormality of DNA repair (HP:0003254)2.92454269
30Abolished electroretinogram (ERG) (HP:0000550)2.90964172
31Renal dysplasia (HP:0000110)2.89247217
32Abnormality of the labia minora (HP:0012880)2.89095205
33Acute encephalopathy (HP:0006846)2.88160083
34Abnormal ciliary motility (HP:0012262)2.86847315
35Abnormality of the ileum (HP:0001549)2.84612011
36Increased CSF lactate (HP:0002490)2.83092617
37Increased hepatocellular lipid droplets (HP:0006565)2.81038977
38Colon cancer (HP:0003003)2.78624524
39Abnormality of alanine metabolism (HP:0010916)2.76796317
40Hyperalaninemia (HP:0003348)2.76796317
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.76796317
42Abnormality of chromosome stability (HP:0003220)2.74451921
43Lipid accumulation in hepatocytes (HP:0006561)2.72982263
44Hyperphosphatemia (HP:0002905)2.72003105
45Mitochondrial inheritance (HP:0001427)2.71390963
46Birth length less than 3rd percentile (HP:0003561)2.70959286
47Tetany (HP:0001281)2.68215986
48Pancreatic fibrosis (HP:0100732)2.57735993
49Septo-optic dysplasia (HP:0100842)2.56434944
50Absent hair (HP:0002298)2.54902194
51Progressive macrocephaly (HP:0004481)2.52245082
52Blepharitis (HP:0000498)2.49740413
53True hermaphroditism (HP:0010459)2.48089622
54Cerebral edema (HP:0002181)2.47909633
55Methylmalonic acidemia (HP:0002912)2.47759114
56Chronic hepatic failure (HP:0100626)2.46501050
57Hypoplasia of the capital femoral epiphysis (HP:0003090)2.45952464
58Pancreatic cysts (HP:0001737)2.44352406
59Absent radius (HP:0003974)2.44275077
60Hepatocellular necrosis (HP:0001404)2.42968658
61Oligohydramnios (HP:0001562)2.41443039
62Renal agenesis (HP:0000104)2.41376996
63Volvulus (HP:0002580)2.37969856
64Osteomalacia (HP:0002749)2.37540026
65Sparse eyelashes (HP:0000653)2.34466938
66Clubbing of toes (HP:0100760)2.33473879
67Hypergonadotropic hypogonadism (HP:0000815)2.32645164
68Increased serum lactate (HP:0002151)2.32021152
69Absent forearm bone (HP:0003953)2.31162387
70Aplasia involving forearm bones (HP:0009822)2.31162387
71Keratitis (HP:0000491)2.28243949
72Hepatic necrosis (HP:0002605)2.26148633
73Abnormal biliary tract physiology (HP:0012439)2.21682822
74Bile duct proliferation (HP:0001408)2.21682822
75Absent thumb (HP:0009777)2.21334220
76Abnormal respiratory motile cilium physiology (HP:0012261)2.21067093
77Type 2 muscle fiber atrophy (HP:0003554)2.19564711
78Horseshoe kidney (HP:0000085)2.12029756
79Abnormal lung lobation (HP:0002101)2.12010720
80Aplasia/Hypoplasia of the tibia (HP:0005772)2.11090134
81Chronic sinusitis (HP:0011109)2.10594222
82Patellar aplasia (HP:0006443)2.09600768
83Abnormality of the pons (HP:0007361)2.08642618
84Glioma (HP:0009733)2.08382218
85Prostate neoplasm (HP:0100787)2.07684105
86Abnormal number of erythroid precursors (HP:0012131)2.07606998
87Triphalangeal thumb (HP:0001199)2.06609024
88Neoplasm of the lung (HP:0100526)2.04394568
89Neoplasm of the respiratory system (HP:0100606)2.03815319
90Congenital, generalized hypertrichosis (HP:0004540)2.03364471
91Short tibia (HP:0005736)2.02957033
92Duplication of thumb phalanx (HP:0009942)2.02069446
93Small intestinal stenosis (HP:0012848)2.01865561
94Duodenal stenosis (HP:0100867)2.01865561
95Small epiphyses (HP:0010585)2.01685103
96Lactic acidosis (HP:0003128)2.00259146
97Rhinitis (HP:0012384)1.99224845
98Methylmalonic aciduria (HP:0012120)1.98828353
99Abnormality of the carotid arteries (HP:0005344)1.97279934
100Oligodactyly (hands) (HP:0001180)1.96036425
101Abnormality of cells of the erythroid lineage (HP:0012130)1.93460985
102Abnormality of serum amino acid levels (HP:0003112)1.93306310
103Medial flaring of the eyebrow (HP:0010747)1.92427895
104Abnormality of homocysteine metabolism (HP:0010919)1.91642645
105Homocystinuria (HP:0002156)1.91642645
106Aplasia/Hypoplasia of the patella (HP:0006498)1.91057849
107Short thumb (HP:0009778)1.87553839
108Sclerocornea (HP:0000647)1.87444788
109Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.86498911
110Absent epiphyses (HP:0010577)1.86498911
111Ependymoma (HP:0002888)1.86069263
112Breast hypoplasia (HP:0003187)1.85910140
113Megaloblastic anemia (HP:0001889)1.85700878
114Decreased activity of mitochondrial respiratory chain (HP:0008972)1.85440163
115Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.85440163
116Intestinal atresia (HP:0011100)1.84584092
117Premature graying of hair (HP:0002216)1.83879129
118Hypoplasia of the pons (HP:0012110)1.83558848
119Bone marrow hypocellularity (HP:0005528)1.82889446
120Pendular nystagmus (HP:0012043)1.81201312
121Cerebellar dysplasia (HP:0007033)1.80575024
122Muscle fiber atrophy (HP:0100295)1.79491058
123Increased serum pyruvate (HP:0003542)1.77921646
124Type II lissencephaly (HP:0007260)1.77399959
125Type I transferrin isoform profile (HP:0003642)1.77180568
126Aplasia/Hypoplasia of the sternum (HP:0006714)1.76763348
127Aganglionic megacolon (HP:0002251)1.76652074
128Abnormality of methionine metabolism (HP:0010901)1.76404078
129Optic nerve coloboma (HP:0000588)1.76162295
130Sloping forehead (HP:0000340)1.74724231
131Macrocytic anemia (HP:0001972)1.74618788
132Ureteral duplication (HP:0000073)1.72506825
133Renal Fanconi syndrome (HP:0001994)1.72082899
134Congenital sensorineural hearing impairment (HP:0008527)1.70251932
135Abnormality of glycolysis (HP:0004366)1.69665786
136Optic disc pallor (HP:0000543)1.69133435
137Exercise intolerance (HP:0003546)1.68882320
138Congenital primary aphakia (HP:0007707)1.67843777
139Neoplasm of the colon (HP:0100273)1.67549228
140Erythema (HP:0010783)1.66723259
141Abnormality of the astrocytes (HP:0100707)1.66629197
142Astrocytoma (HP:0009592)1.66629197
143Abnormality of the renal medulla (HP:0100957)1.66450872
144Abnormality of calcium-phosphate metabolism (HP:0100530)1.66158482
145Aplasia/Hypoplasia involving the musculature (HP:0001460)1.65813586
146Myelodysplasia (HP:0002863)1.65003974
147Conical tooth (HP:0000698)1.64809180
1483-Methylglutaconic aciduria (HP:0003535)1.64728938
149Increased intramyocellular lipid droplets (HP:0012240)1.63866207
150Pancytopenia (HP:0001876)1.63281946
151Microvesicular hepatic steatosis (HP:0001414)1.63113952
152Abnormality of the duodenum (HP:0002246)1.63106972
153Absent septum pellucidum (HP:0001331)1.62362198
154Abnormality of midbrain morphology (HP:0002418)1.62346237
155Molar tooth sign on MRI (HP:0002419)1.62346237
156Abnormality of pyrimidine metabolism (HP:0004353)1.62209895
157Nephroblastoma (Wilms tumor) (HP:0002667)1.59632750
158Melanoma (HP:0002861)1.59483844
159Astigmatism (HP:0000483)1.57803878
160Nephronophthisis (HP:0000090)1.56525927
161Abnormality of the septum pellucidum (HP:0007375)1.55951120

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK36.96999325
2SIK23.91291768
3EPHA23.02279028
4SIK12.98417391
5ZAK2.92647834
6SRPK12.74947265
7STK162.57547740
8NEK12.37566605
9STK38L2.36767054
10VRK22.35789796
11PDK22.32192345
12MARK32.20444066
13CDK82.04653175
14TRIM281.93013920
15VRK11.88881961
16EIF2AK11.87639727
17BUB11.86306226
18CDC71.86245425
19TNIK1.80352028
20NME11.77139519
21TXK1.75229607
22EIF2AK21.74038353
23TTK1.60490246
24PRPF4B1.58901470
25WNK31.57375279
26FRK1.53444691
27WEE11.51006689
28LATS11.47653705
29ADRBK21.45922969
30PLK41.44032626
31CASK1.43489271
32CHEK21.33847683
33CDK71.32728755
34MAP3K41.29655865
35PAK41.29365308
36ATR1.28251476
37MST41.27991577
38YES11.17199413
39PNCK1.15440881
40IRAK41.15215965
41MKNK21.14408337
42IRAK31.12682277
43TAF11.11705300
44ERBB31.10815209
45TAOK21.10766348
46EIF2AK31.10080777
47NEK21.09349010
48MAP4K21.08797474
49BMPR1B1.08562560
50GRK11.08560121
51MKNK11.08481225
52PLK11.08306644
53MAPK131.06725533
54BRD41.04260924
55CCNB11.02274094
56DYRK21.00127231
57PLK30.98613403
58WNK40.98196754
59TLK10.95088613
60ACVR1B0.92891619
61AKT30.92751221
62TGFBR10.89875931
63NUAK10.88809326
64TSSK60.88738723
65MAP3K140.85671562
66SGK20.85164034
67TEC0.83372195
68PLK20.81481350
69MAP3K120.80178063
70CDK30.80126292
71CSNK1G10.75373753
72OXSR10.73751936
73BCKDK0.72154455
74CHEK10.72114272
75DYRK30.72020187
76BRAF0.68684954
77NEK60.68618342
78RPS6KA40.67605029
79BCR0.67085301
80ERBB40.67018503
81TNK20.66286673
82AURKB0.64222305
83BRSK20.63688378
84MAP2K70.62180215
85STK390.61915660
86CAMKK20.60306863
87AURKA0.60106370
88CSNK1G20.59676514
89IRAK20.58152890
90PASK0.57723701
91ATM0.56911866
92GRK70.52663120
93MARK20.51550335
94RPS6KA50.50041008
95CDK40.49942695
96RPS6KB20.48959876
97PRKCG0.45973287
98STK40.45633426
99CSNK1D0.45181053
100CSNK2A20.42582690
101* CSNK2A10.41021031
102NME20.40005397
103BRSK10.39566866
104CSNK1E0.39233605
105STK380.39142657
106LATS20.39037828
107IRAK10.37055020
108NTRK30.36029315
109PINK10.35284045
110PIM20.34191996
111MELK0.33546203
112PBK0.33351989
113NLK0.33295983
114BMPR20.31890027
115CDK20.31224105
116PRKCE0.31215009
117INSRR0.30696582
118CSNK1A1L0.30411763
119CAMK10.30323386
120DAPK10.29990589
121PRKCI0.29525926
122PIM10.29303352
123LYN0.28205859
124IKBKB0.27976067
125CDK10.27913749
126OBSCN0.27258255
127RAF10.27189591
128RPS6KB10.27154027
129MAPKAPK50.26539601
130ALK0.26272009
131PRKDC0.26211578
132CLK10.26100955
133RPS6KL10.25506884
134RPS6KC10.25506884
135ADRBK10.25398126
136AKT10.25241066
137PAK30.24994899
138STK30.24767298
139MAP2K60.24404451
140CSNK1G30.23883890

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.11974782
2Mismatch repair_Homo sapiens_hsa034303.79650539
3Homologous recombination_Homo sapiens_hsa034403.73529692
4Fanconi anemia pathway_Homo sapiens_hsa034603.58775948
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.79310376
6RNA polymerase_Homo sapiens_hsa030202.74897786
7Base excision repair_Homo sapiens_hsa034102.56485184
8Nucleotide excision repair_Homo sapiens_hsa034202.54895767
9Spliceosome_Homo sapiens_hsa030402.48478437
10Oxidative phosphorylation_Homo sapiens_hsa001902.48297120
11Basal transcription factors_Homo sapiens_hsa030222.28412950
12Cell cycle_Homo sapiens_hsa041102.26039300
13Parkinsons disease_Homo sapiens_hsa050122.19604847
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.18849078
15Pyrimidine metabolism_Homo sapiens_hsa002402.12159430
16Non-homologous end-joining_Homo sapiens_hsa034502.10667810
17One carbon pool by folate_Homo sapiens_hsa006702.05896211
18Proteasome_Homo sapiens_hsa030501.96623659
19Ribosome_Homo sapiens_hsa030101.91638060
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88325524
21RNA transport_Homo sapiens_hsa030131.86444469
22Selenocompound metabolism_Homo sapiens_hsa004501.71137808
23Primary immunodeficiency_Homo sapiens_hsa053401.70760778
24Propanoate metabolism_Homo sapiens_hsa006401.66917974
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66834397
26RNA degradation_Homo sapiens_hsa030181.65042375
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.53981167
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.52617688
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51077591
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39288816
31Purine metabolism_Homo sapiens_hsa002301.38666658
32Nicotine addiction_Homo sapiens_hsa050331.35685180
33p53 signaling pathway_Homo sapiens_hsa041151.35485874
34Alzheimers disease_Homo sapiens_hsa050101.34795933
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23885283
36Pyruvate metabolism_Homo sapiens_hsa006201.22924353
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.21046905
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19509595
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17581212
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16846068
41Phototransduction_Homo sapiens_hsa047441.09118165
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.08990567
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08730014
44mRNA surveillance pathway_Homo sapiens_hsa030151.04524006
45Hematopoietic cell lineage_Homo sapiens_hsa046401.03984638
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03759865
47Steroid biosynthesis_Homo sapiens_hsa001001.03113641
48Fatty acid elongation_Homo sapiens_hsa000621.01809011
49Butanoate metabolism_Homo sapiens_hsa006500.98799501
50Protein export_Homo sapiens_hsa030600.97680665
51Mineral absorption_Homo sapiens_hsa049780.97124328
52Cardiac muscle contraction_Homo sapiens_hsa042600.92225859
53Nitrogen metabolism_Homo sapiens_hsa009100.91494895
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91223473
55Herpes simplex infection_Homo sapiens_hsa051680.89404424
56Systemic lupus erythematosus_Homo sapiens_hsa053220.89001001
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88388931
58Sphingolipid metabolism_Homo sapiens_hsa006000.83853346
59Measles_Homo sapiens_hsa051620.82533883
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82025491
61Circadian rhythm_Homo sapiens_hsa047100.81987748
62Sulfur metabolism_Homo sapiens_hsa009200.80773302
63Epstein-Barr virus infection_Homo sapiens_hsa051690.78392068
64Biosynthesis of amino acids_Homo sapiens_hsa012300.76993331
65Folate biosynthesis_Homo sapiens_hsa007900.73902208
66Vitamin B6 metabolism_Homo sapiens_hsa007500.70212890
67Taste transduction_Homo sapiens_hsa047420.69836329
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69805555
69HTLV-I infection_Homo sapiens_hsa051660.68152493
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.67921174
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67909497
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66278540
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65932460
74Melanoma_Homo sapiens_hsa052180.65382298
75Carbon metabolism_Homo sapiens_hsa012000.63096373
76Autoimmune thyroid disease_Homo sapiens_hsa053200.61277602
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59863850
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59817496
79Sulfur relay system_Homo sapiens_hsa041220.59542196
80Glutathione metabolism_Homo sapiens_hsa004800.58743863
81Fatty acid metabolism_Homo sapiens_hsa012120.57572522
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57523718
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57295097
84Arachidonic acid metabolism_Homo sapiens_hsa005900.56618100
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55813751
86Peroxisome_Homo sapiens_hsa041460.55736452
87Serotonergic synapse_Homo sapiens_hsa047260.55121380
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54903466
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54281466
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.52623561
91Wnt signaling pathway_Homo sapiens_hsa043100.52533994
92Calcium signaling pathway_Homo sapiens_hsa040200.50074180
93TGF-beta signaling pathway_Homo sapiens_hsa043500.48738670
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48373200
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47641410
96Lysine degradation_Homo sapiens_hsa003100.46624271
97Notch signaling pathway_Homo sapiens_hsa043300.45151809
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45088655
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44379001
100Tryptophan metabolism_Homo sapiens_hsa003800.43950645
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41935052
102Hedgehog signaling pathway_Homo sapiens_hsa043400.40452366
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40126127
104Graft-versus-host disease_Homo sapiens_hsa053320.39702090
105N-Glycan biosynthesis_Homo sapiens_hsa005100.39560712
106Ovarian steroidogenesis_Homo sapiens_hsa049130.39365182
107MicroRNAs in cancer_Homo sapiens_hsa052060.39207450
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38088698
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37485990
110Allograft rejection_Homo sapiens_hsa053300.37121082
111Huntingtons disease_Homo sapiens_hsa050160.37088778
112Fatty acid biosynthesis_Homo sapiens_hsa000610.36320844
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.35429984
114Hippo signaling pathway_Homo sapiens_hsa043900.35312374
115Alcoholism_Homo sapiens_hsa050340.34810227
116Axon guidance_Homo sapiens_hsa043600.34619895
117Viral carcinogenesis_Homo sapiens_hsa052030.34359814
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34281849
119Linoleic acid metabolism_Homo sapiens_hsa005910.33989802
120T cell receptor signaling pathway_Homo sapiens_hsa046600.33868391
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32229862
122Arginine and proline metabolism_Homo sapiens_hsa003300.30680036
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30031225
124Morphine addiction_Homo sapiens_hsa050320.29918219
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29582740
126beta-Alanine metabolism_Homo sapiens_hsa004100.28495877
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27836590
128Regulation of autophagy_Homo sapiens_hsa041400.27468688
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26383319
130Basal cell carcinoma_Homo sapiens_hsa052170.26363638
131Arginine biosynthesis_Homo sapiens_hsa002200.25994814
132Chemical carcinogenesis_Homo sapiens_hsa052040.25362592
133Ether lipid metabolism_Homo sapiens_hsa005650.25329521
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25116702
135Oocyte meiosis_Homo sapiens_hsa041140.25078243
136Asthma_Homo sapiens_hsa053100.24565033
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24323638
138Apoptosis_Homo sapiens_hsa042100.24150298
139Vitamin digestion and absorption_Homo sapiens_hsa049770.24036214
140Metabolic pathways_Homo sapiens_hsa011000.23817383
141Fatty acid degradation_Homo sapiens_hsa000710.23642937
142FoxO signaling pathway_Homo sapiens_hsa040680.23088503
143Antigen processing and presentation_Homo sapiens_hsa046120.22723623
144alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21325237
145Olfactory transduction_Homo sapiens_hsa047400.21171772
146Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21053103
147Ras signaling pathway_Homo sapiens_hsa040140.20828177
148Influenza A_Homo sapiens_hsa051640.19359200

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