RAD17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.67543088
2cullin deneddylation (GO:0010388)4.66430242
3negative regulation of neurotransmitter secretion (GO:0046929)4.47661902
4nuclear pore organization (GO:0006999)4.44682008
5protein deneddylation (GO:0000338)4.35994748
6nuclear pore complex assembly (GO:0051292)4.23082450
7protein localization to kinetochore (GO:0034501)4.14719227
8* DNA replication checkpoint (GO:0000076)4.13584726
9chromatin remodeling at centromere (GO:0031055)4.08132495
10DNA double-strand break processing (GO:0000729)4.03207368
11metaphase plate congression (GO:0051310)4.01624783
12CENP-A containing nucleosome assembly (GO:0034080)3.97451950
13ribosome assembly (GO:0042255)3.92572840
14resolution of meiotic recombination intermediates (GO:0000712)3.89398120
15purine nucleobase biosynthetic process (GO:0009113)3.87299095
16monoubiquitinated protein deubiquitination (GO:0035520)3.80427057
17DNA replication initiation (GO:0006270)3.78642443
18establishment of chromosome localization (GO:0051303)3.78332579
19positive regulation of amino acid transport (GO:0051957)3.78114281
20mitotic nuclear envelope disassembly (GO:0007077)3.76107247
21attachment of spindle microtubules to kinetochore (GO:0008608)3.75905483
22DNA replication-independent nucleosome assembly (GO:0006336)3.73906206
23DNA replication-independent nucleosome organization (GO:0034724)3.73906206
24protein localization to chromosome, centromeric region (GO:0071459)3.73239693
25DNA replication-dependent nucleosome assembly (GO:0006335)3.71416842
26DNA replication-dependent nucleosome organization (GO:0034723)3.71416842
27nucleobase biosynthetic process (GO:0046112)3.71232298
28negative regulation of DNA-dependent DNA replication (GO:2000104)3.66978972
29maturation of SSU-rRNA (GO:0030490)3.66467356
30histone exchange (GO:0043486)3.64168422
31centriole replication (GO:0007099)3.54637311
32mitotic chromosome condensation (GO:0007076)3.51891179
33piRNA metabolic process (GO:0034587)3.51867481
34membrane disassembly (GO:0030397)3.49753306
35nuclear envelope disassembly (GO:0051081)3.49753306
36negative regulation of neurotransmitter transport (GO:0051589)3.48660551
37DNA strand elongation involved in DNA replication (GO:0006271)3.45742842
38ribosome biogenesis (GO:0042254)3.43171256
39spindle checkpoint (GO:0031577)3.42860073
40serotonin receptor signaling pathway (GO:0007210)3.41926097
41positive regulation of catecholamine secretion (GO:0033605)3.41124346
42regulation of RNA export from nucleus (GO:0046831)3.40709279
43synaptonemal complex assembly (GO:0007130)3.39102538
44positive regulation of chromosome segregation (GO:0051984)3.37908807
45DNA unwinding involved in DNA replication (GO:0006268)3.36954219
46regulation of meiosis I (GO:0060631)3.36247982
47kinetochore organization (GO:0051383)3.34688618
48synapsis (GO:0007129)3.34326623
49regulation of spindle organization (GO:0090224)3.33007122
50protein K6-linked ubiquitination (GO:0085020)3.32587445
51branched-chain amino acid catabolic process (GO:0009083)3.32212604
52pore complex assembly (GO:0046931)3.30622169
53DNA strand elongation (GO:0022616)3.27536697
54regulation of centriole replication (GO:0046599)3.27409362
55maturation of 5.8S rRNA (GO:0000460)3.26160878
56spindle assembly checkpoint (GO:0071173)3.25952993
57protein K11-linked ubiquitination (GO:0070979)3.24338767
58negative regulation of sister chromatid segregation (GO:0033046)3.23782428
59negative regulation of mitotic sister chromatid separation (GO:2000816)3.23782428
60negative regulation of mitotic sister chromatid segregation (GO:0033048)3.23782428
61negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.23782428
62mitotic spindle checkpoint (GO:0071174)3.22367753
63regulation of mitotic metaphase/anaphase transition (GO:0030071)3.21887787
64negative regulation of chromosome segregation (GO:0051985)3.21836968
65ribonucleoprotein complex disassembly (GO:0032988)3.21469467
66regulation of chromosome segregation (GO:0051983)3.21304869
67regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.20726535
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19747375
69negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.18333608
70regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.17720395
71synaptonemal complex organization (GO:0070193)3.14940287
72mitotic spindle assembly checkpoint (GO:0007094)3.14665882
73folic acid-containing compound biosynthetic process (GO:0009396)3.13734252
74neural tube formation (GO:0001841)3.13165590
75spliceosomal snRNP assembly (GO:0000387)3.12090765
76mitotic G2/M transition checkpoint (GO:0044818)3.11935080
77chromatin assembly or disassembly (GO:0006333)3.10455097
78somatic hypermutation of immunoglobulin genes (GO:0016446)3.09542526
79somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09542526
80male meiosis (GO:0007140)3.07551568
81mitotic sister chromatid cohesion (GO:0007064)3.06799075
82IMP biosynthetic process (GO:0006188)3.06677396
83regulation of sister chromatid segregation (GO:0033045)3.05314813
84regulation of mitotic sister chromatid separation (GO:0010965)3.05314813
85regulation of mitotic sister chromatid segregation (GO:0033047)3.05314813
86ATP-dependent chromatin remodeling (GO:0043044)3.04842730
87maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.04178587
88regulation of DNA endoreduplication (GO:0032875)3.04088206
89meiotic chromosome segregation (GO:0045132)3.03471643
90protein localization to chromosome (GO:0034502)3.03430600
91male meiosis I (GO:0007141)3.03336678
92negative regulation of amino acid transport (GO:0051956)3.00305182
93negative regulation of DNA recombination (GO:0045910)3.00084236
94female gonad development (GO:0008585)2.99797151
95proteasome assembly (GO:0043248)2.99559324
96organelle disassembly (GO:1903008)2.99439788
97telomere maintenance via semi-conservative replication (GO:0032201)2.99423651
98positive regulation of mitotic sister chromatid separation (GO:1901970)2.97160472
99positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.97160472
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.97160472
101RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.96561957
102regulation of centrosome cycle (GO:0046605)2.96267846
103DNA ligation (GO:0006266)2.95122908
104kinetochore assembly (GO:0051382)2.94619823
105regulation of double-strand break repair via homologous recombination (GO:0010569)2.93183046
106histone H2A acetylation (GO:0043968)2.92745960
107telomere maintenance via recombination (GO:0000722)2.92420630
108sister chromatid cohesion (GO:0007062)2.91307025
109formation of translation preinitiation complex (GO:0001731)2.88749958
110postreplication repair (GO:0006301)2.88586252
111regulation of mitotic spindle organization (GO:0060236)2.88349945
112exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.88189452
113mitotic G2 DNA damage checkpoint (GO:0007095)2.86961840
114regulation of mitotic spindle checkpoint (GO:1903504)2.86407146
115regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.86407146
116histone mRNA metabolic process (GO:0008334)2.85612530
117meiotic nuclear division (GO:0007126)2.81964791
118somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.81036533
119isotype switching (GO:0045190)2.81036533
120somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.81036533
121DNA methylation involved in gamete generation (GO:0043046)2.80687954
122transcription elongation from RNA polymerase II promoter (GO:0006368)2.80542824
123viral mRNA export from host cell nucleus (GO:0046784)2.80442763
124nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80316874
125mitotic recombination (GO:0006312)2.79885501
126regulation of nuclear cell cycle DNA replication (GO:0033262)2.79772100
127spliceosomal complex assembly (GO:0000245)2.78461485
128regulation of posttranscriptional gene silencing (GO:0060147)2.78447418
129regulation of gene silencing by miRNA (GO:0060964)2.78447418
130regulation of gene silencing by RNA (GO:0060966)2.78447418
131ribonucleoprotein complex biogenesis (GO:0022613)2.76642616
132rRNA processing (GO:0006364)2.76133049
133rRNA methylation (GO:0031167)2.75799640
134replication fork processing (GO:0031297)2.75351715
135regulation of histone H3-K9 methylation (GO:0051570)2.74419980
136regulation of helicase activity (GO:0051095)2.74175704
1377-methylguanosine mRNA capping (GO:0006370)2.74059785
138nuclear envelope organization (GO:0006998)2.73403697
139mitotic sister chromatid segregation (GO:0000070)2.72678584
140DNA geometric change (GO:0032392)2.72460665
141epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.69143122
142sister chromatid segregation (GO:0000819)2.68176819
143intraciliary transport (GO:0042073)2.64751415
144negative regulation of meiosis (GO:0045835)2.63711017
145positive regulation of histone H3-K4 methylation (GO:0051571)2.62842076
146preassembly of GPI anchor in ER membrane (GO:0016254)2.62080873
147recombinational repair (GO:0000725)2.62060005
148double-strand break repair via homologous recombination (GO:0000724)2.61598788
149protein neddylation (GO:0045116)2.58605869
150isoprenoid biosynthetic process (GO:0008299)2.57632701
151response to pheromone (GO:0019236)2.56720874
152regulation of glutamate secretion (GO:0014048)2.55798134
153microtubule anchoring (GO:0034453)2.53169035
154termination of RNA polymerase II transcription (GO:0006369)2.53113630
155DNA catabolic process, exonucleolytic (GO:0000738)2.50391149
156branched-chain amino acid metabolic process (GO:0009081)2.50224448
157non-recombinational repair (GO:0000726)2.49140974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.44975574
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.92157831
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.67850669
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.66825458
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.49512629
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.17109356
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.03525534
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.98637766
9* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.95211003
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.83067043
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.77607275
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.76854847
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.75301743
14IGF1R_20145208_ChIP-Seq_DFB_Human2.73226930
15ZNF274_21170338_ChIP-Seq_K562_Hela2.68899804
16EWS_26573619_Chip-Seq_HEK293_Human2.67331296
17* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.66104224
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59692645
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.54900755
20VDR_22108803_ChIP-Seq_LS180_Human2.50113652
21FUS_26573619_Chip-Seq_HEK293_Human2.44258173
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38228078
23* VDR_23849224_ChIP-Seq_CD4+_Human2.37706536
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36585362
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32350164
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29942641
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.26507057
28AR_21909140_ChIP-Seq_LNCAP_Human2.20504421
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.19732828
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19581017
31FLI1_27457419_Chip-Seq_LIVER_Mouse2.12987703
32XRN2_22483619_ChIP-Seq_HELA_Human2.10340939
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08560301
34E2F1_21310950_ChIP-Seq_MCF-7_Human2.04569177
35* FOXP3_21729870_ChIP-Seq_TREG_Human2.03204795
36ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02465297
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96079479
38ELK1_19687146_ChIP-ChIP_HELA_Human1.95245988
39DCP1A_22483619_ChIP-Seq_HELA_Human1.93318574
40* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90243763
41GBX2_23144817_ChIP-Seq_PC3_Human1.89373557
42GABP_19822575_ChIP-Seq_HepG2_Human1.88163356
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86082750
44P300_19829295_ChIP-Seq_ESCs_Human1.85953674
45* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85951189
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81871400
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79842831
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78118802
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74840065
50TAF15_26573619_Chip-Seq_HEK293_Human1.70768895
51* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70377940
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69803919
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.69401591
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68893983
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68134530
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67332700
57KDM5A_27292631_Chip-Seq_BREAST_Human1.66146576
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65731456
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65357529
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63390201
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58473048
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57711361
63TTF2_22483619_ChIP-Seq_HELA_Human1.56719828
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54841037
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50057258
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.48566993
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48538556
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46572671
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45140514
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42735921
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42181476
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41647455
73ER_23166858_ChIP-Seq_MCF-7_Human1.40931542
74CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39258398
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38927737
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38511050
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.38495149
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36856930
79CIITA_25753668_ChIP-Seq_RAJI_Human1.36602271
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.34487420
81TFEB_21752829_ChIP-Seq_HELA_Human1.33639763
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31934933
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31662847
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30464377
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30011236
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29589580
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27249421
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27129969
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26313512
90MYC_22102868_ChIP-Seq_BL_Human1.25964050
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.25715624
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25431980
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25093238
94YY1_21170310_ChIP-Seq_MESCs_Mouse1.24840881
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24430348
96TP53_22573176_ChIP-Seq_HFKS_Human1.23288127
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22799351
98CBP_20019798_ChIP-Seq_JUKART_Human1.19394369
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19394369
100STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18334960
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17844583
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.15251877
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.15225831
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14841983
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.12220737
106KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12168971
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12025193
108NANOG_16153702_ChIP-ChIP_HESCs_Human1.10957436
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10942899
110SMAD4_21799915_ChIP-Seq_A2780_Human1.10802421
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10658096
112SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09934919
113PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08214462
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07916546
115RNF2_27304074_Chip-Seq_NSC_Mouse1.07109527
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05744016
117FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05255986
118BCAT_22108803_ChIP-Seq_LS180_Human1.04645319
119SOX2_16153702_ChIP-ChIP_HESCs_Human1.04498886
120* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02457705
121NANOG_19829295_ChIP-Seq_ESCs_Human1.02078743
122SOX2_19829295_ChIP-Seq_ESCs_Human1.02078743
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01769807
124* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01761888
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.01072722
126TAL1_26923725_Chip-Seq_HPCs_Mouse1.00416491
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99296017
128PIAS1_25552417_ChIP-Seq_VCAP_Human0.99276126
129STAT3_23295773_ChIP-Seq_U87_Human0.97875333
130EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97429361
131TCF4_22108803_ChIP-Seq_LS180_Human0.96789061
132P53_22387025_ChIP-Seq_ESCs_Mouse0.96735391
133BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96715903
134DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96484496
135HTT_18923047_ChIP-ChIP_STHdh_Human0.96449577
136MYC_18940864_ChIP-ChIP_HL60_Human0.95910394
137FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95291236
138P300_18555785_Chip-Seq_ESCs_Mouse0.94678326
139RUNX2_22187159_ChIP-Seq_PCA_Human0.94626636
140IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93895222
141NANOG_21062744_ChIP-ChIP_HESCs_Human0.93607909
142* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92565546
143SPI1_23547873_ChIP-Seq_NB4_Human0.90681980
144SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89464782
145CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88760521
146SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88520909
147KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88025205
148NOTCH1_21737748_ChIP-Seq_TLL_Human0.87083791
149POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84291318
150ELK1_22589737_ChIP-Seq_MCF10A_Human0.83493831
151SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82937851
152* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82297294
153GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81756783
154CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81235822
155SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.79988744
156POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76377037
157CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73269485
158HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.72513825
159SOX17_20123909_ChIP-Seq_XEN_Mouse0.71150956
160CHD1_26751641_Chip-Seq_LNCaP_Human0.69823269
161TBX5_21415370_ChIP-Seq_HL-1_Mouse0.68845267

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.18534812
2MP0010094_abnormal_chromosome_stability4.45042559
3MP0008057_abnormal_DNA_replication3.93875833
4MP0003077_abnormal_cell_cycle3.93283217
5MP0003111_abnormal_nucleus_morphology3.92846293
6MP0004957_abnormal_blastocyst_morpholog3.78245341
7MP0008058_abnormal_DNA_repair3.62115738
8MP0008877_abnormal_DNA_methylation3.59614256
9MP0001529_abnormal_vocalization2.84611601
10MP0008007_abnormal_cellular_replicative2.83730284
11MP0002102_abnormal_ear_morphology2.82543124
12MP0003787_abnormal_imprinting2.56513217
13MP0002163_abnormal_gland_morphology2.49255983
14MP0003123_paternal_imprinting2.48860651
15MP0001730_embryonic_growth_arrest2.40518528
16MP0010307_abnormal_tumor_latency2.22484888
17MP0000350_abnormal_cell_proliferation2.09506313
18MP0008932_abnormal_embryonic_tissue2.08029854
19MP0003786_premature_aging2.06755214
20MP0002210_abnormal_sex_determination1.98882170
21MP0003880_abnormal_central_pattern1.96000473
22MP0001929_abnormal_gametogenesis1.93020883
23MP0003718_maternal_effect1.85470582
24MP0010352_gastrointestinal_tract_polyps1.80833397
25MP0002234_abnormal_pharynx_morphology1.78522774
26MP0006072_abnormal_retinal_apoptosis1.76448047
27MP0005379_endocrine/exocrine_gland_phen1.73194110
28MP0001672_abnormal_embryogenesis/_devel1.73065236
29MP0005380_embryogenesis_phenotype1.73065236
30MP0002822_catalepsy1.68041154
31MP0008961_abnormal_basal_metabolism1.67825384
32MP0001697_abnormal_embryo_size1.66851981
33MP0001145_abnormal_male_reproductive1.66203660
34MP0004215_abnormal_myocardial_fiber1.59298675
35MP0003984_embryonic_growth_retardation1.58121426
36MP0000569_abnormal_digit_pigmentation1.56316586
37MP0002837_dystrophic_cardiac_calcinosis1.56277015
38MP0002088_abnormal_embryonic_growth/wei1.53566719
39MP0000653_abnormal_sex_gland1.49899601
40MP0003806_abnormal_nucleotide_metabolis1.49490775
41MP0005253_abnormal_eye_physiology1.49401298
42MP0002396_abnormal_hematopoietic_system1.43976861
43* MP0002080_prenatal_lethality1.41068810
44MP0003195_calcinosis1.40535969
45MP0002084_abnormal_developmental_patter1.38465202
46* MP0002085_abnormal_embryonic_tissue1.34691998
47MP0002086_abnormal_extraembryonic_tissu1.32723351
48MP0009697_abnormal_copulation1.32685374
49MP0000313_abnormal_cell_death1.30962724
50MP0000372_irregular_coat_pigmentation1.30164556
51MP0001188_hyperpigmentation1.28627642
52MP0003122_maternal_imprinting1.27458250
53MP0009333_abnormal_splenocyte_physiolog1.26236051
54MP0006035_abnormal_mitochondrial_morpho1.25397394
55MP0005076_abnormal_cell_differentiation1.24948495
56MP0001984_abnormal_olfaction1.21981431
57MP0002019_abnormal_tumor_incidence1.21630376
58MP0005410_abnormal_fertilization1.18954779
59MP0003890_abnormal_embryonic-extraembry1.18777705
60MP0002751_abnormal_autonomic_nervous1.17829213
61MP0006292_abnormal_olfactory_placode1.17639652
62MP0003698_abnormal_male_reproductive1.17502383
63MP0005408_hypopigmentation1.15982454
64MP0002653_abnormal_ependyma_morphology1.15449534
65MP0003121_genomic_imprinting1.15412754
66MP0001119_abnormal_female_reproductive1.14742596
67MP0003763_abnormal_thymus_physiology1.13467348
68MP0004782_abnormal_surfactant_physiolog1.11412677
69MP0004808_abnormal_hematopoietic_stem1.10957922
70MP0006276_abnormal_autonomic_nervous1.10881411
71MP0009672_abnormal_birth_weight1.10370159
72MP0002160_abnormal_reproductive_system1.10096676
73MP0004142_abnormal_muscle_tone1.09074457
74MP0008789_abnormal_olfactory_epithelium1.07910900
75MP0000490_abnormal_crypts_of1.07361495
76MP0004197_abnormal_fetal_growth/weight/1.07062087
77MP0003567_abnormal_fetal_cardiomyocyte1.05896286
78MP0005551_abnormal_eye_electrophysiolog1.03601801
79MP0005389_reproductive_system_phenotype1.01944473
80MP0000703_abnormal_thymus_morphology1.01464364
81MP0003186_abnormal_redox_activity1.00597811
82MP0003656_abnormal_erythrocyte_physiolo0.98743969
83MP0002398_abnormal_bone_marrow0.97883873
84MP0002233_abnormal_nose_morphology0.96416003
85MP0001293_anophthalmia0.95286456
86MP0005367_renal/urinary_system_phenotyp0.90231153
87MP0000516_abnormal_urinary_system0.90231153
88MP0000647_abnormal_sebaceous_gland0.89871518
89MP0005645_abnormal_hypothalamus_physiol0.89525166
90MP0002161_abnormal_fertility/fecundity0.88769880
91MP0000689_abnormal_spleen_morphology0.88243764
92MP0000778_abnormal_nervous_system0.87866564
93MP0001986_abnormal_taste_sensitivity0.86557953
94MP0002877_abnormal_melanocyte_morpholog0.85995646
95MP0005075_abnormal_melanosome_morpholog0.85916243
96MP0000631_abnormal_neuroendocrine_gland0.85361767
97MP0005499_abnormal_olfactory_system0.84705821
98MP0005394_taste/olfaction_phenotype0.84705821
99MP0001853_heart_inflammation0.84226927
100MP0001286_abnormal_eye_development0.83061770
101MP0010386_abnormal_urinary_bladder0.82778862
102MP0002177_abnormal_outer_ear0.82026295
103MP0002722_abnormal_immune_system0.81504501
104MP0002184_abnormal_innervation0.80925290
105MP0005395_other_phenotype0.80565467
106MP0009703_decreased_birth_body0.80245815
107MP0003221_abnormal_cardiomyocyte_apopto0.80112410
108MP0001545_abnormal_hematopoietic_system0.79659272
109MP0005397_hematopoietic_system_phenotyp0.79659272
110MP0000358_abnormal_cell_content/0.78771922
111MP0000049_abnormal_middle_ear0.78073715
112MP0006036_abnormal_mitochondrial_physio0.77430838
113MP0001666_abnormal_nutrient_absorption0.77377692
114MP0010030_abnormal_orbit_morphology0.75499878
115MP0004264_abnormal_extraembryonic_tissu0.75068843
116MP0000858_altered_metastatic_potential0.74908895
117MP0004885_abnormal_endolymph0.74401793
118MP0002009_preneoplasia0.74251257
119MP0005386_behavior/neurological_phenoty0.74064868
120MP0004924_abnormal_behavior0.74064868
121MP0005384_cellular_phenotype0.74014271
122MP0002429_abnormal_blood_cell0.73893149
123MP0003699_abnormal_female_reproductive0.73854362
124MP0005621_abnormal_cell_physiology0.73621540
125MP0001177_atelectasis0.72181791
126MP0002938_white_spotting0.71708920
127MP0001915_intracranial_hemorrhage0.71704839
128MP0002090_abnormal_vision0.71405676
129MP0001764_abnormal_homeostasis0.70979146
130MP0003937_abnormal_limbs/digits/tail_de0.70973047
131MP0005391_vision/eye_phenotype0.70047969
132MP0001835_abnormal_antigen_presentation0.68410456
133MP0005266_abnormal_metabolism0.67305063
134MP0000716_abnormal_immune_system0.66949969
135MP0004133_heterotaxia0.66087247
136MP0003828_pulmonary_edema0.65689785
137MP0003941_abnormal_skin_development0.65123552
138MP0006054_spinal_hemorrhage0.61380140
139MP0005220_abnormal_exocrine_pancreas0.59126448
140MP0002693_abnormal_pancreas_physiology0.58402196
141MP0003943_abnormal_hepatobiliary_system0.54321630
142MP0002127_abnormal_cardiovascular_syste0.53434997
143MP0001944_abnormal_pancreas_morphology0.52097728
144MP0001919_abnormal_reproductive_system0.51857844
145MP0003119_abnormal_digestive_system0.51607770
146MP0008995_early_reproductive_senescence0.51530372
147MP0000432_abnormal_head_morphology0.49668641
148MP0002638_abnormal_pupillary_reflex0.49337930
149MP0001800_abnormal_humoral_immune0.49059604
150* MP0000598_abnormal_liver_morphology0.48758254
151MP0000428_abnormal_craniofacial_morphol0.48711160

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.15522661
2Chromsome breakage (HP:0040012)4.92508126
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.63361285
4Impulsivity (HP:0100710)3.97450898
5Abnormality of chromosome stability (HP:0003220)3.67307197
6Degeneration of anterior horn cells (HP:0002398)3.60685734
7Abnormality of the anterior horn cell (HP:0006802)3.60685734
8Breast hypoplasia (HP:0003187)3.37593457
9Reticulocytopenia (HP:0001896)3.22219913
10Methylmalonic acidemia (HP:0002912)3.21239575
11Patellar aplasia (HP:0006443)3.20448774
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.17831294
13Meckel diverticulum (HP:0002245)3.17012850
14Abnormality of the preputium (HP:0100587)3.13598221
15Hypoplasia of the capital femoral epiphysis (HP:0003090)3.12128415
16Abnormality of the heme biosynthetic pathway (HP:0010472)3.11926129
17Ectopic kidney (HP:0000086)3.11794226
18Abnormal spermatogenesis (HP:0008669)3.06370946
19Duplicated collecting system (HP:0000081)3.04422508
20Abnormality of the ileum (HP:0001549)2.99163579
21Aplasia/Hypoplasia of the patella (HP:0006498)2.94248431
22Medial flaring of the eyebrow (HP:0010747)2.92834518
23Carpal bone hypoplasia (HP:0001498)2.89264702
24Myelodysplasia (HP:0002863)2.84247165
25Abnormality of the renal collecting system (HP:0004742)2.75068515
26Absent radius (HP:0003974)2.66562995
27Sloping forehead (HP:0000340)2.66449937
28Absent thumb (HP:0009777)2.66087451
29Duodenal stenosis (HP:0100867)2.62492135
30Small intestinal stenosis (HP:0012848)2.62492135
31Ureteral duplication (HP:0000073)2.58712826
32Stenosis of the external auditory canal (HP:0000402)2.56274986
3311 pairs of ribs (HP:0000878)2.51407327
34Abnormality of aspartate family amino acid metabolism (HP:0010899)2.51042352
35Abnormality of methionine metabolism (HP:0010901)2.49169068
36Pancreatic islet-cell hyperplasia (HP:0004510)2.46439559
37Nephrogenic diabetes insipidus (HP:0009806)2.41354451
38Abnormality of midbrain morphology (HP:0002418)2.37799403
39Molar tooth sign on MRI (HP:0002419)2.37799403
40Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.37733007
41Absent epiphyses (HP:0010577)2.37733007
42Clubbing of toes (HP:0100760)2.37514709
43Renal cortical cysts (HP:0000803)2.36817696
44Congenital primary aphakia (HP:0007707)2.36626408
45Absent forearm bone (HP:0003953)2.36497135
46Aplasia involving forearm bones (HP:0009822)2.36497135
47Prominent nose (HP:0000448)2.34532309
48Increased hepatocellular lipid droplets (HP:0006565)2.33363694
49Azoospermia (HP:0000027)2.33317850
50Abnormality of the labia minora (HP:0012880)2.32707342
51Bone marrow hypocellularity (HP:0005528)2.31550570
52Gait imbalance (HP:0002141)2.31025143
53Selective tooth agenesis (HP:0001592)2.30486040
54Aplastic anemia (HP:0001915)2.30136389
55Methylmalonic aciduria (HP:0012120)2.28817204
56Nephronophthisis (HP:0000090)2.28064015
57Intestinal atresia (HP:0011100)2.25412051
58Cerebral edema (HP:0002181)2.23834886
59Oral leukoplakia (HP:0002745)2.23417555
60Secondary amenorrhea (HP:0000869)2.23067350
61Horseshoe kidney (HP:0000085)2.20701992
62Genital tract atresia (HP:0001827)2.19640517
63Abnormality of the renal cortex (HP:0011035)2.18948069
64Neoplasm of the adrenal cortex (HP:0100641)2.18521528
65Cafe-au-lait spot (HP:0000957)2.17946146
66Thyroid carcinoma (HP:0002890)2.17052013
67Lipid accumulation in hepatocytes (HP:0006561)2.17027071
68Abnormality of the pancreatic islet cells (HP:0006476)2.16317703
69Abnormality of endocrine pancreas physiology (HP:0012093)2.16317703
70Gonadotropin excess (HP:0000837)2.15832599
71Abnormality of the duodenum (HP:0002246)2.14962943
72Papillary thyroid carcinoma (HP:0002895)2.14779620
73Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.12654501
74Abnormal lung lobation (HP:0002101)2.11504523
75Abnormality of the carotid arteries (HP:0005344)2.10605912
76Overlapping toe (HP:0001845)2.10052168
77Rough bone trabeculation (HP:0100670)2.08699873
78Nephroblastoma (Wilms tumor) (HP:0002667)2.05898952
79Neoplasm of the adrenal gland (HP:0100631)2.05778521
80Abnormality of the renal medulla (HP:0100957)1.99612720
81Vaginal atresia (HP:0000148)1.99603889
82Medulloblastoma (HP:0002885)1.99346512
83Cortical dysplasia (HP:0002539)1.96923634
84Embryonal renal neoplasm (HP:0011794)1.96233005
85Colon cancer (HP:0003003)1.96109661
86Abnormal biliary tract morphology (HP:0012440)1.95696528
87Chronic hepatic failure (HP:0100626)1.95688150
88Poor coordination (HP:0002370)1.95012157
89Abnormality of pyrimidine metabolism (HP:0004353)1.94795768
90Astigmatism (HP:0000483)1.94632489
91Abnormality of DNA repair (HP:0003254)1.93914028
92Hyperglycinemia (HP:0002154)1.93151917
93Abnormality of serum amino acid levels (HP:0003112)1.91954497
94True hermaphroditism (HP:0010459)1.91908134
95Increased CSF lactate (HP:0002490)1.91773557
96Abnormality of the vitamin B12 metabolism (HP:0004341)1.91681134
97Cellular immunodeficiency (HP:0005374)1.91651442
98Abnormality of lateral ventricle (HP:0030047)1.91449524
99Capillary hemangiomas (HP:0005306)1.91242581
100Thrombocytosis (HP:0001894)1.90824670
101Abnormal protein N-linked glycosylation (HP:0012347)1.90557818
102Abnormal protein glycosylation (HP:0012346)1.90557818
103Abnormal glycosylation (HP:0012345)1.90557818
104Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90557818
105Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.90450856
106Facial hemangioma (HP:0000329)1.89940218
107Prominent metopic ridge (HP:0005487)1.89303769
108Abnormality of vitamin B metabolism (HP:0004340)1.87796215
109Hyperinsulinemic hypoglycemia (HP:0000825)1.86894340
110Supernumerary spleens (HP:0009799)1.86288033
111Acute myeloid leukemia (HP:0004808)1.85941291
112Facial cleft (HP:0002006)1.85710628
113Aplasia/Hypoplasia of the sternum (HP:0006714)1.84530931
114Dyskinesia (HP:0100660)1.83195318
115Missing ribs (HP:0000921)1.81548078
116Volvulus (HP:0002580)1.81241018
117High pitched voice (HP:0001620)1.81104570
118Gastrointestinal atresia (HP:0002589)1.80770156
119Hypoglycemic seizures (HP:0002173)1.80685293
120Tongue fasciculations (HP:0001308)1.79883703
121Short thumb (HP:0009778)1.79016927
122Pancreatic fibrosis (HP:0100732)1.78878327
123Reduced antithrombin III activity (HP:0001976)1.78630407
124Microretrognathia (HP:0000308)1.78091307
125Large for gestational age (HP:0001520)1.77997191
126Pulmonary fibrosis (HP:0002206)1.77779940
127Ketosis (HP:0001946)1.77431445
128Rhabdomyosarcoma (HP:0002859)1.77088307
129Optic nerve coloboma (HP:0000588)1.76310770
130Abnormality of the metopic suture (HP:0005556)1.76198560
131Acute encephalopathy (HP:0006846)1.76056027
132Median cleft lip (HP:0000161)1.75810414
133Abnormality of alanine metabolism (HP:0010916)1.74904942
134Hyperalaninemia (HP:0003348)1.74904942
135Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.74904942
136Decreased testicular size (HP:0008734)1.74822127
137Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74555296
138Septo-optic dysplasia (HP:0100842)1.74042740
139Acute necrotizing encephalopathy (HP:0006965)1.73747456
140Tubulointerstitial nephritis (HP:0001970)1.73735957
141Type I transferrin isoform profile (HP:0003642)1.73689536
142Postaxial hand polydactyly (HP:0001162)1.73429160
143Abolished electroretinogram (ERG) (HP:0000550)1.73190361
144Premature graying of hair (HP:0002216)1.73091271
145Abnormal pancreas size (HP:0012094)1.73003101
146Multiple enchondromatosis (HP:0005701)1.70251956
147Oligohydramnios (HP:0001562)1.69944953
148Pancreatic cysts (HP:0001737)1.69535248
149Recurrent bronchitis (HP:0002837)1.69448940
150Hypoglycemic coma (HP:0001325)1.69295479
151Pancytopenia (HP:0001876)1.68010358
152Rhabdomyolysis (HP:0003201)1.67750123
153Arteriovenous malformation (HP:0100026)1.67712223
154Limb hypertonia (HP:0002509)1.67503884
155Short middle phalanx of the 5th finger (HP:0004220)1.67313081
156Abnormality of homocysteine metabolism (HP:0010919)1.67061582
157Homocystinuria (HP:0002156)1.67061582
158Abnormal biliary tract physiology (HP:0012439)1.66445221
159Sandal gap (HP:0001852)1.66261208
160Bronchitis (HP:0012387)1.65486401
161Triphalangeal thumb (HP:0001199)1.64326026
162Hyperglycemia (HP:0003074)1.62274695
163Spinal muscular atrophy (HP:0007269)1.62003247
164Neoplasm of the pancreas (HP:0002894)1.61719553
165Ovarian neoplasm (HP:0100615)1.61432128

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK24.37886165
2TRIM284.16415805
3CDC73.81175211
4PLK43.70128120
5BCR3.39971100
6WEE13.32678344
7BUB13.08457631
8SRPK12.87440880
9EIF2AK12.74069194
10NEK22.49505833
11ACVR1B2.35286464
12TTK2.30705526
13PDK42.08661949
14PDK32.08661949
15BRSK12.02345030
16BMPR1B2.00846026
17DYRK32.00648851
18PLK31.94080475
19PLK11.91938770
20PASK1.89609157
21EIF2AK31.88541539
22MARK31.81997104
23STK38L1.81469853
24CHEK21.80145488
25MAP3K41.59855183
26FLT31.59697057
27TSSK61.58654537
28AURKB1.56370354
29CDK121.55673291
30STK101.52115130
31MAPK131.50975603
32TAF11.47857749
33TNIK1.45594051
34* ATR1.39696162
35NEK11.36070964
36PBK1.31355847
37RPS6KA41.31189216
38PNCK1.30710930
39MAP2K71.30495221
40SCYL21.30205058
41SIK31.24224945
42CHEK11.23690463
43NME21.22667023
44PINK11.21872525
45MAP4K21.17716482
46VRK11.17416569
47GRK11.15069241
48PDK21.14670982
49CDK71.14579978
50ZAK1.12715713
51MELK1.10802272
52CSNK1G11.06332303
53BRAF1.06164386
54CCNB11.05716512
55RPS6KB21.04152281
56MKNK11.02737186
57STK41.02686160
58PLK21.02657651
59CSNK1G21.02557839
60CSNK1G31.01023585
61MKNK21.00303373
62NUAK10.95897193
63TESK20.95211566
64MAP3K80.94901806
65* ATM0.94708982
66CASK0.93901001
67CSNK1A1L0.93530405
68AURKA0.90026520
69STK390.84900455
70STK30.84184031
71TLK10.84130704
72TGFBR10.83107154
73TESK10.82947954
74MINK10.81495043
75PRKCE0.79368237
76PIM10.77594472
77CDK20.75640491
78WNK40.74275318
79EPHA40.72969342
80STK160.72589065
81MAP4K10.71849668
82FRK0.70255164
83CDK40.69935931
84MARK10.68111777
85NEK90.66757883
86AKT30.66236400
87TAOK30.65812052
88VRK20.62769834
89LATS10.61504591
90IRAK30.61138977
91CSNK2A10.60670874
92CSNK2A20.60659791
93CDK10.59073000
94KSR10.58267759
95JAK30.56857175
96CDK80.54843326
97OXSR10.54347323
98WNK30.53102600
99EIF2AK20.52507397
100MUSK0.51876566
101PAK30.51422643
102RPS6KA50.50785074
103ADRBK20.50464002
104EPHA20.48907095
105PRKD30.48055771
106ZAP700.46915723
107BRD40.46756265
108INSRR0.45526806
109MAP3K90.43703943
110TYK20.43639651
111TRPM70.43287851
112CHUK0.43120267
113DYRK1B0.42638191
114CDK30.42631349
115CDK90.42196648
116IRAK40.41565994
117MST40.40892878
118PRKCI0.40744560
119DYRK20.40653272
120OBSCN0.39957081
121MAP3K140.39436480
122EEF2K0.35565801
123PAK10.35525540
124LMTK20.35506914
125PRKCG0.35488547
126CDK190.34937777
127CSNK1E0.32183665
128NLK0.31808754
129TXK0.31756092
130STK240.30368660
131CSNK1A10.30100887
132CSNK1D0.30010470
133YES10.29914390
134ERBB30.29189682
135PKN10.28697541
136* PRKDC0.28255883
137RPS6KB10.27864275
138BCKDK0.27703542
139CDK60.27655629
140TEC0.26667893
141FGFR20.26010987
142PRKAA10.25991147
143LRRK20.25741587
144ITK0.24317497

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.87913163
2DNA replication_Homo sapiens_hsa030303.74277461
3RNA transport_Homo sapiens_hsa030133.25081620
4Mismatch repair_Homo sapiens_hsa034303.19272567
5RNA polymerase_Homo sapiens_hsa030203.15185883
6Cell cycle_Homo sapiens_hsa041102.94266537
7Spliceosome_Homo sapiens_hsa030402.90824217
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.88998149
9Proteasome_Homo sapiens_hsa030502.84349008
10Basal transcription factors_Homo sapiens_hsa030222.83646098
11Homologous recombination_Homo sapiens_hsa034402.66535840
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.56198857
13Base excision repair_Homo sapiens_hsa034102.55162327
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.54974732
15RNA degradation_Homo sapiens_hsa030182.46982932
16Non-homologous end-joining_Homo sapiens_hsa034502.46459129
17Fanconi anemia pathway_Homo sapiens_hsa034602.40881891
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.40252216
19Protein export_Homo sapiens_hsa030602.40157556
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.39716970
21Nucleotide excision repair_Homo sapiens_hsa034202.36782622
22One carbon pool by folate_Homo sapiens_hsa006702.28367865
23Pyrimidine metabolism_Homo sapiens_hsa002402.09266377
24mRNA surveillance pathway_Homo sapiens_hsa030151.95766369
25Vitamin B6 metabolism_Homo sapiens_hsa007501.95597231
26Ribosome_Homo sapiens_hsa030101.91498547
27Steroid biosynthesis_Homo sapiens_hsa001001.78686488
28p53 signaling pathway_Homo sapiens_hsa041151.69217845
29Butanoate metabolism_Homo sapiens_hsa006501.62923655
30Phototransduction_Homo sapiens_hsa047441.47836187
31Pentose phosphate pathway_Homo sapiens_hsa000301.40085429
32Antigen processing and presentation_Homo sapiens_hsa046121.38864394
33Epstein-Barr virus infection_Homo sapiens_hsa051691.35071413
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.28454816
35Purine metabolism_Homo sapiens_hsa002301.27328908
36Selenocompound metabolism_Homo sapiens_hsa004501.24215247
37Herpes simplex infection_Homo sapiens_hsa051681.18583622
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17364281
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17001286
40Fatty acid elongation_Homo sapiens_hsa000621.16215436
41Oxidative phosphorylation_Homo sapiens_hsa001901.11037979
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08451714
43Peroxisome_Homo sapiens_hsa041461.05262995
44Systemic lupus erythematosus_Homo sapiens_hsa053221.04869871
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04348994
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02612479
47Viral carcinogenesis_Homo sapiens_hsa052031.02402279
48Parkinsons disease_Homo sapiens_hsa050120.98087102
49Oocyte meiosis_Homo sapiens_hsa041140.96543464
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92759058
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90987131
52beta-Alanine metabolism_Homo sapiens_hsa004100.90685802
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89746689
54Nitrogen metabolism_Homo sapiens_hsa009100.83530896
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80995980
56Sulfur relay system_Homo sapiens_hsa041220.79335321
57Biosynthesis of amino acids_Homo sapiens_hsa012300.76794934
58Olfactory transduction_Homo sapiens_hsa047400.74491973
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73557096
60Nicotine addiction_Homo sapiens_hsa050330.73332712
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73212857
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73155402
63Regulation of autophagy_Homo sapiens_hsa041400.72899818
64Legionellosis_Homo sapiens_hsa051340.69764885
65Carbon metabolism_Homo sapiens_hsa012000.69713612
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.68946566
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67421983
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67177425
69Circadian rhythm_Homo sapiens_hsa047100.63688047
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61181758
71Retinol metabolism_Homo sapiens_hsa008300.60190907
72Folate biosynthesis_Homo sapiens_hsa007900.59501413
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.59481651
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58917435
75Fatty acid degradation_Homo sapiens_hsa000710.58653226
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57899234
77Thyroid cancer_Homo sapiens_hsa052160.57441000
78MicroRNAs in cancer_Homo sapiens_hsa052060.55534200
79HTLV-I infection_Homo sapiens_hsa051660.55417241
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.54822552
81Fatty acid metabolism_Homo sapiens_hsa012120.54266489
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54201538
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54171186
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.52250325
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51003022
86Huntingtons disease_Homo sapiens_hsa050160.50433923
87Hedgehog signaling pathway_Homo sapiens_hsa043400.49978802
88Small cell lung cancer_Homo sapiens_hsa052220.48041919
89Measles_Homo sapiens_hsa051620.47413514
90Apoptosis_Homo sapiens_hsa042100.46958697
91Serotonergic synapse_Homo sapiens_hsa047260.45242419
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45174880
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44989002
94ABC transporters_Homo sapiens_hsa020100.44153473
95Starch and sucrose metabolism_Homo sapiens_hsa005000.43605018
96Wnt signaling pathway_Homo sapiens_hsa043100.42215446
97Tryptophan metabolism_Homo sapiens_hsa003800.41487701
98Linoleic acid metabolism_Homo sapiens_hsa005910.41242706
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41082120
100TGF-beta signaling pathway_Homo sapiens_hsa043500.40925660
101Arginine and proline metabolism_Homo sapiens_hsa003300.40714618
102Influenza A_Homo sapiens_hsa051640.40273884
103Taste transduction_Homo sapiens_hsa047420.36142451
104Amphetamine addiction_Homo sapiens_hsa050310.35890106
105Caffeine metabolism_Homo sapiens_hsa002320.35136716
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34801913
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34761997
108Alzheimers disease_Homo sapiens_hsa050100.34352208
109Hepatitis B_Homo sapiens_hsa051610.34322369
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33052781
111Dopaminergic synapse_Homo sapiens_hsa047280.32426783
112GABAergic synapse_Homo sapiens_hsa047270.31815515
113Galactose metabolism_Homo sapiens_hsa000520.31646737
114Prostate cancer_Homo sapiens_hsa052150.31435368
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.31164304
116Propanoate metabolism_Homo sapiens_hsa006400.31078338
117Ether lipid metabolism_Homo sapiens_hsa005650.30710964
118Primary immunodeficiency_Homo sapiens_hsa053400.30154829
119FoxO signaling pathway_Homo sapiens_hsa040680.29953761
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29699109
121N-Glycan biosynthesis_Homo sapiens_hsa005100.29029988
122Lysine degradation_Homo sapiens_hsa003100.28468523
123Hippo signaling pathway_Homo sapiens_hsa043900.28314839
124Hematopoietic cell lineage_Homo sapiens_hsa046400.26627436
125Graft-versus-host disease_Homo sapiens_hsa053320.26113771
126Fructose and mannose metabolism_Homo sapiens_hsa000510.25712361
127Metabolic pathways_Homo sapiens_hsa011000.25285355
128Type I diabetes mellitus_Homo sapiens_hsa049400.23898998
129Insulin secretion_Homo sapiens_hsa049110.23817717
130Glutathione metabolism_Homo sapiens_hsa004800.23740666
131Shigellosis_Homo sapiens_hsa051310.23582175
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22992583
133Alcoholism_Homo sapiens_hsa050340.22816710
134Viral myocarditis_Homo sapiens_hsa054160.22795856
135Adherens junction_Homo sapiens_hsa045200.21908576
136Pyruvate metabolism_Homo sapiens_hsa006200.21779981
137Basal cell carcinoma_Homo sapiens_hsa052170.20648818
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.20442309
139RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15996164
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.15024999
141Arachidonic acid metabolism_Homo sapiens_hsa005900.14662343
142HIF-1 signaling pathway_Homo sapiens_hsa040660.13960810
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13548244
144Renin-angiotensin system_Homo sapiens_hsa046140.13479549
145Colorectal cancer_Homo sapiens_hsa052100.12677237
146Autoimmune thyroid disease_Homo sapiens_hsa053200.12057727
147Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.11409015
148Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.11280526
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09572880
150Thyroid hormone signaling pathway_Homo sapiens_hsa049190.08637843
151Pancreatic cancer_Homo sapiens_hsa052120.08228343

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