ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	phospholipid scrambling (GO:0017121)	9.42123413
2	positive regulation of catecholamine secretion (GO:0033605)	9.38522085
3	negative regulation of amino acid transport (GO:0051956)	9.31225799
4	regulation of glutamate secretion (GO:0014048)	7.53343138
5	negative regulation of neurotransmitter transport (GO:0051589)	6.85209172
6	intestinal epithelial cell development (GO:0060576)	6.77066442
7	serotonin receptor signaling pathway (GO:0007210)	6.61166230
8	mannose metabolic process (GO:0006013)	6.54183936
9	pharyngeal system development (GO:0060037)	6.28795990
10	DNA replication checkpoint (GO:0000076)	5.69881128
11	N-glycan processing (GO:0006491)	5.50532266
12	UDP-N-acetylglucosamine metabolic process (GO:0006047)	5.05613989
13	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.05359126
14	positive regulation of organic acid transport (GO:0032892)	5.05137529
15	regulation of membrane lipid distribution (GO:0097035)	4.76388724
16	negative regulation of organic acid transport (GO:0032891)	4.64140450
17	cellular response to ATP (GO:0071318)	4.63378066
18	negative regulation of activin receptor signaling pathway (GO:0032926)	4.61930937
19	early endosome to late endosome transport (GO:0045022)	4.59820199
20	regulation of dopamine secretion (GO:0014059)	4.55588046
21	negative regulation of protein tyrosine kinase activity (GO:0061099)	4.48615202
22	regulation of amino acid transport (GO:0051955)	4.33133693
23	muscle cell fate commitment (GO:0042693)	4.28693400
24	activated T cell proliferation (GO:0050798)	4.18526414
25	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.17466606
26	protein K48-linked deubiquitination (GO:0071108)	4.15597570
27	positive regulation of amine transport (GO:0051954)	4.15193227
28	protein K63-linked deubiquitination (GO:0070536)	4.11600688
29	flavonoid metabolic process (GO:0009812)	3.93705845
30	pathway-restricted SMAD protein phosphorylation (GO:0060389)	3.92816073
31	cilium or flagellum-dependent cell motility (GO:0001539)	3.91388592
32	negative regulation of amine transport (GO:0051953)	3.89796870
33	positive regulation of immune response to tumor cell (GO:0002839)	3.86997749
34	regulation of immune response to tumor cell (GO:0002837)	3.86997749
35	regulation of response to tumor cell (GO:0002834)	3.86997749
36	positive regulation of response to tumor cell (GO:0002836)	3.86997749
37	urogenital system development (GO:0001655)	3.86377493
38	axonemal dynein complex assembly (GO:0070286)	3.83396159
39	axoneme assembly (GO:0035082)	3.79030355
40	branched-chain amino acid catabolic process (GO:0009083)	3.71127562
41	epithelial cell fate commitment (GO:0072148)	3.64626564
42	cellular glucuronidation (GO:0052695)	3.60509125
43	cilium movement (GO:0003341)	3.50890643
44	glomerular visceral epithelial cell development (GO:0072015)	3.46490311
45	glucuronate metabolic process (GO:0019585)	3.46451970
46	uronic acid metabolic process (GO:0006063)	3.46451970
47	necroptotic process (GO:0070266)	3.42939690
48	epithelial cilium movement (GO:0003351)	3.42656918
49	positive regulation of protein kinase C signaling (GO:0090037)	3.42159068
50	phospholipid translocation (GO:0045332)	3.40714847
51	lipid translocation (GO:0034204)	3.40714847
52	actin filament capping (GO:0051693)	3.30372870
53	T cell mediated immunity (GO:0002456)	3.28839192
54	glomerular epithelial cell development (GO:0072310)	3.23910901
55	regulation of cell-cell adhesion mediated by cadherin (GO:2000047)	3.09962353
56	negative regulation of gluconeogenesis (GO:0045721)	3.08387399
57	Golgi to endosome transport (GO:0006895)	3.04165967
58	rRNA catabolic process (GO:0016075)	3.00134148
59	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.98633215
60	branched-chain amino acid metabolic process (GO:0009081)	2.97745159
61	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.97716415
62	microtubule nucleation (GO:0007020)	2.96857690
63	keratinocyte development (GO:0003334)	2.96157744
64	heme transport (GO:0015886)	2.95866289
65	nucleotide-sugar metabolic process (GO:0009225)	2.95758406
66	base-excision repair, AP site formation (GO:0006285)	2.95740397
67	cAMP catabolic process (GO:0006198)	2.93523549
68	regulation of hippo signaling (GO:0035330)	2.92980497
69	cullin deneddylation (GO:0010388)	2.91754030
70	lung lobe morphogenesis (GO:0060463)	2.90832526
71	mannosylation (GO:0097502)	2.86392844
72	columnar/cuboidal epithelial cell development (GO:0002066)	2.83157374
73	negative regulation of mast cell activation (GO:0033004)	2.82992070
74	plasma membrane repair (GO:0001778)	2.81041951
75	tight junction assembly (GO:0070830)	2.80006440
76	benzene-containing compound metabolic process (GO:0042537)	2.78434375
77	long-term synaptic potentiation (GO:0060291)	2.72340688
78	motile cilium assembly (GO:0044458)	2.72145828
79	mature B cell differentiation involved in immune response (GO:0002313)	2.65728465
80	phenylpropanoid metabolic process (GO:0009698)	2.65657344
81	cyclic nucleotide catabolic process (GO:0009214)	2.64688968
82	regulation of RIG-I signaling pathway (GO:0039535)	2.58351236
83	exocrine pancreas development (GO:0031017)	2.56533615
84	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.54273635
85	positive regulation of histone H3-K4 methylation (GO:0051571)	2.52666474
86	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.52238501
87	regulation of action potential (GO:0098900)	2.51419069
88	negative regulation of actin filament depolymerization (GO:0030835)	2.51098924
89	sulfate transmembrane transport (GO:1902358)	2.47705014
90	protein deneddylation (GO:0000338)	2.47212822
91	retinal cone cell development (GO:0046549)	2.44026829
92	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.43869687
93	programmed necrotic cell death (GO:0097300)	2.42036075
94	atrial septum morphogenesis (GO:0060413)	2.41192275
95	protein K11-linked deubiquitination (GO:0035871)	2.41010689
96	peroxisome fission (GO:0016559)	2.40427813
97	regulation of female receptivity (GO:0045924)	2.40216862
98	endosome organization (GO:0007032)	2.39314784
99	positive regulation of amino acid transport (GO:0051957)	10.3213282
100	negative regulation of neurotransmitter secretion (GO:0046929)	10.2843990

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	3.57652305
2	VDR_22108803_ChIP-Seq_LS180_Human	3.21429603
3	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.70518141
4	EWS_26573619_Chip-Seq_HEK293_Human	2.43156813
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.32702405
6	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.30702733
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.28668013
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.11617717
9	ER_23166858_ChIP-Seq_MCF-7_Human	2.05581052
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.00995104
11	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.00139508
12	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.89971139
13	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.81174584
14	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.79576111
15	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.78801817
16	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.75473513
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.74473747
18	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.73086116
19	P300_19829295_ChIP-Seq_ESCs_Human	1.73039913
20	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.68573860
21	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.59479716
22	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.54259818
23	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.53461065
24	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.53275246
25	ZNF274_21170338_ChIP-Seq_K562_Hela	1.52778352
26	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.50731761
27	CJUN_26792858_Chip-Seq_BT549_Human	1.47513425
28	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.47059148
29	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.46275568
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.41605476
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41263325
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.41205249
33	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.41104744
34	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.38791365
35	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.37817585
36	SMAD4_21799915_ChIP-Seq_A2780_Human	1.37790235
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.37747866
38	FUS_26573619_Chip-Seq_HEK293_Human	1.36756458
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36574300
40	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.36007709
41	TCF4_22108803_ChIP-Seq_LS180_Human	1.35889913
42	STAT3_23295773_ChIP-Seq_U87_Human	1.34549007
43	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.33651388
44	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.33453962
45	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.33361610
46	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.32983079
47	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.32291923
48	AR_21572438_ChIP-Seq_LNCaP_Human	1.29288004
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.25511284
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25511284
51	BCAT_22108803_ChIP-Seq_LS180_Human	1.25452418
52	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.24035810
53	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.23640761
54	DROSHA_22980978_ChIP-Seq_HELA_Human	1.23401619
55	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.23138144
56	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.23019516
57	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.22723788
58	AHR_22903824_ChIP-Seq_MCF-7_Human	1.21380638
59	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.21163423
60	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.20844330
61	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.20844330
62	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.20823145
63	AR_25329375_ChIP-Seq_VCAP_Human	1.20214567
64	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.18345291
65	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.17748539
66	GATA4_25053715_ChIP-Seq_YYC3_Human	1.17383310
67	CDX2_22108803_ChIP-Seq_LS180_Human	1.16575072
68	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.16546672
69	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.15496984
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15291733
71	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.14250800
72	TCF4_23295773_ChIP-Seq_U87_Human	1.14120558
73	KDM2B_26808549_Chip-Seq_REH_Human	1.12295581
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11657062
75	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11657062
76	TP53_16413492_ChIP-PET_HCT116_Human	1.11225313
77	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.10843851
78	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.10579461
79	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.09918089
80	TP63_23658742_ChIP-Seq_EP156T_Human	1.08946398
81	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08713106
82	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.06529363
83	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.06364435
84	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.06190871
85	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05910350
86	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05494194
87	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.04927190
88	LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.04808950
89	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.04228875
90	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03562873
91	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02069910
92	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02069910
93	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.01537627
94	TBL1_22424771_ChIP-Seq_293T_Human	1.01450485
95	TAF2_19829295_ChIP-Seq_ESCs_Human	1.00346940
96	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.98900742
97	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.97775344
98	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.97020317
99	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.96853284
100	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.96779381

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008961_abnormal_basal_metabolism	6.74636093
2	MP0002822_catalepsy	4.82451091
3	MP0004782_abnormal_surfactant_physiolog	3.44346297
4	MP0002234_abnormal_pharynx_morphology	2.77996206
5	MP0002396_abnormal_hematopoietic_system	2.67611858
6	MP0002163_abnormal_gland_morphology	2.41340739
7	MP0003183_abnormal_peptide_metabolism	2.37959571
8	MP0003656_abnormal_erythrocyte_physiolo	2.31300555
9	MP0000383_abnormal_hair_follicle	2.28131489
10	MP0001666_abnormal_nutrient_absorption	2.18313004
11	MP0002009_preneoplasia	2.14026016
12	MP0008875_abnormal_xenobiotic_pharmacok	2.07798859
13	MP0005275_abnormal_skin_tensile	2.00393648
14	MP0002166_altered_tumor_susceptibility	1.97718411
15	MP0003868_abnormal_feces_composition	1.91185093
16	MP0005167_abnormal_blood-brain_barrier	1.88086739
17	MP0005379_endocrine/exocrine_gland_phen	1.86413036
18	MP0000678_abnormal_parathyroid_gland	1.75423646
19	MP0002102_abnormal_ear_morphology	1.74328564
20	MP0005365_abnormal_bile_salt	1.74227215
21	MP0003453_abnormal_keratinocyte_physiol	1.69740868
22	MP0004142_abnormal_muscle_tone	1.67079359
23	MP0004484_altered_response_of	1.66875505
24	MP0008995_early_reproductive_senescence	1.64828849
25	MP0003890_abnormal_embryonic-extraembry	1.59301370
26	MP0000613_abnormal_salivary_gland	1.58440745
27	MP0002837_dystrophic_cardiac_calcinosis	1.57601045
28	MP0005409_darkened_coat_color	1.56578059
29	MP0005408_hypopigmentation	1.55407112
30	MP0003136_yellow_coat_color	1.44419903
31	MP0008057_abnormal_DNA_replication	1.43736851
32	MP0001873_stomach_inflammation	1.43473025
33	MP0002876_abnormal_thyroid_physiology	1.41009851
34	MP0010678_abnormal_skin_adnexa	1.40723469
35	MP0002735_abnormal_chemical_nociception	1.40477327
36	MP0009780_abnormal_chondrocyte_physiolo	1.40300742
37	MP0002277_abnormal_respiratory_mucosa	1.39648052
38	MP0001664_abnormal_digestion	1.39426487
39	MP0005389_reproductive_system_phenotype	1.39373918
40	MP0003045_fibrosis	1.37966798
41	MP0008872_abnormal_physiological_respon	1.37318089
42	MP0004043_abnormal_pH_regulation	1.35406766
43	MP0002160_abnormal_reproductive_system	1.33038471
44	MP0005085_abnormal_gallbladder_physiolo	1.32253241
45	MP0002282_abnormal_trachea_morphology	1.30558203
46	MP0003300_gastrointestinal_ulcer	1.27197941
47	MP0000470_abnormal_stomach_morphology	1.24299496
48	MP0001919_abnormal_reproductive_system	1.22143586
49	MP0001790_abnormal_immune_system	1.21159553
50	MP0005387_immune_system_phenotype	1.21159553
51	MP0008007_abnormal_cellular_replicative	1.19447933
52	MP0004808_abnormal_hematopoietic_stem	1.18121791
53	MP0003283_abnormal_digestive_organ	1.17556291
54	MP0001216_abnormal_epidermal_layer	1.15623563
55	MP0002006_tumorigenesis	1.13603838
56	MP0001346_abnormal_lacrimal_gland	1.13440917
57	MP0002653_abnormal_ependyma_morphology	1.11860916
58	MP0003866_abnormal_defecation	1.10109738
59	MP0009643_abnormal_urine_homeostasis	1.08795617
60	MP0004215_abnormal_myocardial_fiber	1.08460886
61	MP0001191_abnormal_skin_condition	1.07861295
62	MP0009333_abnormal_splenocyte_physiolog	1.07430175
63	MP0002249_abnormal_larynx_morphology	1.06921935
64	MP0001348_abnormal_lacrimal_gland	1.06705224
65	MP0004134_abnormal_chest_morphology	1.06267142
66	MP0005551_abnormal_eye_electrophysiolog	1.04203628
67	MP0005083_abnormal_biliary_tract	1.02870980
68	MP0002136_abnormal_kidney_physiology	0.99869060
69	MP0003638_abnormal_response/metabolism_	0.98124140
70	MP0005410_abnormal_fertilization	0.95908215
71	MP0005503_abnormal_tendon_morphology	0.92373595
72	MP0006054_spinal_hemorrhage	0.91547600
73	MP0004264_abnormal_extraembryonic_tissu	0.90409144
74	MP0003828_pulmonary_edema	0.87911745
75	MP0000490_abnormal_crypts_of	0.87730106
76	MP0000427_abnormal_hair_cycle	0.85364800
77	MP0005646_abnormal_pituitary_gland	0.84709904
78	MP0000372_irregular_coat_pigmentation	0.83571473
79	MP0003195_calcinosis	0.81967262
80	MP0000049_abnormal_middle_ear	0.81962426
81	MP0010155_abnormal_intestine_physiology	0.81849250
82	MP0000163_abnormal_cartilage_morphology	0.80003935
83	MP0008438_abnormal_cutaneous_collagen	0.78914138
84	MP0002405_respiratory_system_inflammati	0.78837605
85	MP0002098_abnormal_vibrissa_morphology	0.76327893
86	MP0005671_abnormal_response_to	0.74732588
87	MP0005166_decreased_susceptibility_to	0.74585372
88	MP0008004_abnormal_stomach_pH	0.73849041
89	MP0002060_abnormal_skin_morphology	0.71949665
90	MP0002108_abnormal_muscle_morphology	0.71704287
91	MP0005171_absent_coat_pigmentation	0.71143752
92	MP0000477_abnormal_intestine_morphology	0.70813761
93	MP0004381_abnormal_hair_follicle	0.70593740
94	MP0000367_abnormal_coat/_hair	0.69990063
95	MP0003119_abnormal_digestive_system	0.69749537
96	MP0002133_abnormal_respiratory_system	0.66009573
97	MP0005388_respiratory_system_phenotype	0.66009573
98	MP0005332_abnormal_amino_acid	0.65909886
99	MP0002135_abnormal_kidney_morphology	0.65779699
100	MP0002733_abnormal_thermal_nociception	0.65295828

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the renal collecting system (HP:0004742)	6.95919700
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	6.12646979
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.50793612
4	Absent/shortened dynein arms (HP:0200106)	5.50793612
5	Duplicated collecting system (HP:0000081)	5.24702498
6	Short 1st metacarpal (HP:0010034)	4.34017304
7	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	4.34017304
8	Abnormal rod and cone electroretinograms (HP:0008323)	3.88517048
9	Abnormality of the 1st metacarpal (HP:0010009)	3.88291870
10	Chronic hepatic failure (HP:0100626)	3.80622824
11	Ketosis (HP:0001946)	3.79315521
12	Abnormality of DNA repair (HP:0003254)	3.70038642
13	Lip pit (HP:0100267)	3.67076890
14	Methylmalonic acidemia (HP:0002912)	3.58823808
15	Abnormal ciliary motility (HP:0012262)	3.48678728
16	Abnormal respiratory epithelium morphology (HP:0012253)	3.42682083
17	Abnormal respiratory motile cilium morphology (HP:0005938)	3.42682083
18	Large for gestational age (HP:0001520)	3.30889411
19	Vertebral hypoplasia (HP:0008417)	3.30886825
20	Aplasia/Hypoplasia of the vertebrae (HP:0008515)	3.30886825
21	Short phalanx of the thumb (HP:0009660)	3.28674516
22	Menorrhagia (HP:0000132)	3.21473154
23	Abnormality of the intrinsic pathway (HP:0010989)	3.16059202
24	Abnormal respiratory motile cilium physiology (HP:0012261)	3.10030879
25	Hypoproteinemia (HP:0003075)	3.04180656
26	High pitched voice (HP:0001620)	2.94516387
27	Abnormality of the common coagulation pathway (HP:0010990)	2.92797357
28	Fused cervical vertebrae (HP:0002949)	2.69870654
29	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.69135485
30	Type I transferrin isoform profile (HP:0003642)	2.60892442
31	Attenuation of retinal blood vessels (HP:0007843)	2.59846090
32	Reduced antithrombin III activity (HP:0001976)	2.58096503
33	Pendular nystagmus (HP:0012043)	2.57826890
34	Concave nail (HP:0001598)	2.56501013
35	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.56173910
36	Right ventricular cardiomyopathy (HP:0011663)	2.55104275
37	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	2.53956232
38	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.53777901
39	Decreased central vision (HP:0007663)	2.51168958
40	Ureteral duplication (HP:0000073)	2.48729459
41	Abnormal biliary tract morphology (HP:0012440)	2.45684365
42	Short hallux (HP:0010109)	2.45534799
43	Pancreatic cysts (HP:0001737)	2.42527969
44	Abnormality of vitamin B metabolism (HP:0004340)	2.42228714
45	Striae distensae (HP:0001065)	2.41493744
46	Methylmalonic aciduria (HP:0012120)	2.39561279
47	Pancreatic fibrosis (HP:0100732)	2.35522876
48	Chronic sinusitis (HP:0011109)	2.35443510
49	Keratoconus (HP:0000563)	2.33936414
50	Increased corneal curvature (HP:0100692)	2.33936414
51	J-shaped sella turcica (HP:0002680)	2.31701279
52	Stenosis of the external auditory canal (HP:0000402)	2.31240647
53	Hyperactive renin-angiotensin system (HP:0000841)	2.23491623
54	Milia (HP:0001056)	2.22185746
55	Pancreatic islet-cell hyperplasia (HP:0004510)	2.21135632
56	Pancreatitis (HP:0001733)	2.19832144
57	Autoimmune hemolytic anemia (HP:0001890)	2.19141881
58	True hermaphroditism (HP:0010459)	2.18560832
59	Rhinitis (HP:0012384)	2.18214401
60	Cerebral edema (HP:0002181)	2.14769351
61	Nephronophthisis (HP:0000090)	2.13387221
62	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.12985454
63	Abnormal protein N-linked glycosylation (HP:0012347)	2.12985454
64	Abnormal protein glycosylation (HP:0012346)	2.12985454
65	Abnormal glycosylation (HP:0012345)	2.12985454
66	Poor head control (HP:0002421)	2.10396937
67	Abnormality of the renal cortex (HP:0011035)	2.08636762
68	Tubular atrophy (HP:0000092)	2.04685119
69	Clubbing of toes (HP:0100760)	2.01627339
70	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.00511458
71	Abnormality of the renal medulla (HP:0100957)	2.00466506
72	Decreased circulating renin level (HP:0003351)	2.00288693
73	Widely spaced teeth (HP:0000687)	1.99461436
74	Abnormality of the pancreatic islet cells (HP:0006476)	1.97155125
75	Abnormality of endocrine pancreas physiology (HP:0012093)	1.97155125
76	Abolished electroretinogram (ERG) (HP:0000550)	1.95191157
77	Morphological abnormality of the middle ear (HP:0008609)	1.92324416
78	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.91642435
79	Abnormal pancreas size (HP:0012094)	1.90948780
80	Constricted visual fields (HP:0001133)	1.90866385
81	Flat acetabular roof (HP:0003180)	1.90820093
82	Absent thumb (HP:0009777)	1.89306273
83	Abnormal finger flexion creases (HP:0006143)	1.88170300
84	Bronchiectasis (HP:0002110)	1.85267121
85	Abnormality of vitamin metabolism (HP:0100508)	1.85180059
86	Hypochromic anemia (HP:0001931)	1.83439890
87	11 pairs of ribs (HP:0000878)	1.83107150
88	Abnormality of the anterior horn cell (HP:0006802)	1.78915709
89	Degeneration of anterior horn cells (HP:0002398)	1.78915709
90	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.75317974
91	Chronic bronchitis (HP:0004469)	1.74259826
92	Glycosuria (HP:0003076)	1.70314075
93	Abnormality of urine glucose concentration (HP:0011016)	1.70314075
94	Hypoplasia of the pons (HP:0012110)	1.69108322
95	Abnormality of the pons (HP:0007361)	1.68617774
96	Hyperaldosteronism (HP:0000859)	1.68011493
97	Abnormality of cochlea (HP:0000375)	1.67548507
98	Down-sloping shoulders (HP:0200021)	1.66753851
99	Exotropia (HP:0000577)	1.66624519
100	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.66256901

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK3	5.92803034
2	MUSK	2.65835698
3	FRK	2.65482372
4	TGFBR2	2.17591305
5	FER	2.13344069
6	BCKDK	12.5006157
7	MST4	1.81715452
8	IKBKE	1.73350803
9	BCR	1.61777623
10	GRK1	1.57833945
11	NEK9	1.47060316
12	DAPK2	1.27776056
13	EPHA3	1.20571599
14	CHUK	1.10903745
15	EPHA2	1.07777180
16	EIF2AK2	1.07752081
17	WNK1	1.04629508
18	ADRBK2	1.02924066
19	WNK4	1.01667985
20	MST1R	0.99523523
21	PAK3	0.97906112
22	BUB1	0.97883655
23	PRKCI	0.97353564
24	TLK1	0.95643045
25	ERBB3	0.93192263
26	MAPKAPK5	0.89994020
27	EPHB1	0.89930170
28	IKBKB	0.87961959
29	ACVR1B	0.84425504
30	MAPK15	0.81153547
31	PRKCE	0.76132125
32	IRAK1	0.75657667
33	NME1	0.74101533
34	RPS6KA6	0.73575645
35	ABL1	0.70536100
36	ATR	0.66527544
37	BRSK2	0.65855806
38	MAPK13	0.64947146
39	STK38	0.64533195
40	AKT3	0.63253977
41	STK39	0.59989543
42	NUAK1	0.59074280
43	RPS6KC1	0.56575523
44	RPS6KL1	0.56575523
45	RPS6KA2	0.52207477
46	INSRR	0.51220871
47	PHKG2	0.50212037
48	PHKG1	0.50212037
49	TAOK3	0.47907564
50	PLK4	0.46440095
51	NLK	0.42322382
52	PRKAA2	0.42161958
53	MAP2K1	0.41813637
54	MAPKAPK2	0.41723159
55	MAP2K6	0.40406986
56	HIPK2	0.40297575
57	MAP3K3	0.40166254
58	PTK2B	0.38589320
59	PTK6	0.38448497
60	INSR	0.38283002
61	MET	0.38128899
62	ERBB2	0.36799348
63	OXSR1	0.36194863
64	GSK3A	0.36152981
65	STK11	0.36034271
66	MARK3	0.35971743
67	ZAP70	0.35405928
68	PIM1	0.34971774
69	FGFR1	0.33924741
70	PRKG2	0.33733198
71	TRIM28	0.33610966
72	PBK	0.32998499
73	TXK	0.32559609
74	RPS6KB1	0.32466777
75	TAF1	0.29025061
76	PRKCD	0.29002311
77	ADRBK1	0.27183089
78	PRKDC	0.25680391
79	TIE1	0.24767701
80	PIK3CA	0.24623841
81	AKT2	0.24275754
82	WNK3	0.23766322
83	IGF1R	0.23181231
84	MAP3K2	0.22292683
85	SGK2	0.20340404
86	MYLK	0.19897328
87	ABL2	0.17005397
88	BMPR1B	0.16729833
89	KIT	0.16614375
90	TEC	0.16501011
91	MAP2K2	0.16276197
92	PRKACA	0.16099085
93	PRKCA	0.14843241
94	TSSK6	0.13878277
95	MAPK3	0.13298303
96	PINK1	0.12506984
97	CSNK1D	0.12119888
98	PRKD2	0.11681419
99	RPS6KA5	0.11163128
100	TBK1	0.10965073

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur relay system_Homo sapiens_hsa04122	5.02480586
2	Propanoate metabolism_Homo sapiens_hsa00640	3.53163169
3	N-Glycan biosynthesis_Homo sapiens_hsa00510	2.97960115
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.75646121
5	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.73407326
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.64805782
7	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.63419520
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.57621566
9	Starch and sucrose metabolism_Homo sapiens_hsa00500	2.52213158
10	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.44434104
11	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.39494256
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.31358132
13	Nitrogen metabolism_Homo sapiens_hsa00910	2.20888975
14	Retinol metabolism_Homo sapiens_hsa00830	2.12741374
15	Chemical carcinogenesis_Homo sapiens_hsa05204	2.10570136
16	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.76849456
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.74459262
18	Histidine metabolism_Homo sapiens_hsa00340	1.73486314
19	ABC transporters_Homo sapiens_hsa02010	1.71265056
20	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.70151927
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.69891729
22	Caffeine metabolism_Homo sapiens_hsa00232	1.66904932
23	Mineral absorption_Homo sapiens_hsa04978	1.58328277
24	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.56279101
25	Fatty acid elongation_Homo sapiens_hsa00062	1.49740177
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.45420851
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.36313249
28	Renin-angiotensin system_Homo sapiens_hsa04614	1.33461928
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.33347959
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.23336627
31	Selenocompound metabolism_Homo sapiens_hsa00450	1.22402150
32	Fat digestion and absorption_Homo sapiens_hsa04975	1.20626384
33	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.18014514
34	Sphingolipid metabolism_Homo sapiens_hsa00600	1.16288275
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.13936838
36	beta-Alanine metabolism_Homo sapiens_hsa00410	1.11928837
37	Sulfur metabolism_Homo sapiens_hsa00920	1.10315099
38	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.08320479
39	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.04533122
40	Serotonergic synapse_Homo sapiens_hsa04726	1.02500030
41	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.00493309
42	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.97260349
43	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.96989745
44	Phototransduction_Homo sapiens_hsa04744	0.96950588
45	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.94993049
46	Galactose metabolism_Homo sapiens_hsa00052	0.94213904
47	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.91507715
48	Protein digestion and absorption_Homo sapiens_hsa04974	0.89966948
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.88156664
50	Salivary secretion_Homo sapiens_hsa04970	0.86204936
51	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.84293838
52	Insulin secretion_Homo sapiens_hsa04911	0.81940874
53	Bile secretion_Homo sapiens_hsa04976	0.78551548
54	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.72369089
55	Calcium signaling pathway_Homo sapiens_hsa04020	0.71447098
56	Type I diabetes mellitus_Homo sapiens_hsa04940	0.71021141
57	Renin secretion_Homo sapiens_hsa04924	0.68449943
58	Butanoate metabolism_Homo sapiens_hsa00650	0.67309478
59	Fatty acid degradation_Homo sapiens_hsa00071	0.66102491
60	Peroxisome_Homo sapiens_hsa04146	0.65713295
61	Tyrosine metabolism_Homo sapiens_hsa00350	0.64690218
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.60579997
63	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.60565009
64	Olfactory transduction_Homo sapiens_hsa04740	0.60560734
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.58065160
66	cAMP signaling pathway_Homo sapiens_hsa04024	0.56680588
67	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.56178513
68	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.55591203
69	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.54808487
70	Pancreatic secretion_Homo sapiens_hsa04972	0.51692654
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.49883158
72	PPAR signaling pathway_Homo sapiens_hsa03320	0.48271480
73	Fatty acid metabolism_Homo sapiens_hsa01212	0.46055583
74	Basal cell carcinoma_Homo sapiens_hsa05217	0.41926253
75	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.40858258
76	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.40143518
77	Taste transduction_Homo sapiens_hsa04742	0.39943785
78	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.39628625
79	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.38446624
80	Gastric acid secretion_Homo sapiens_hsa04971	0.38310872
81	Metabolic pathways_Homo sapiens_hsa01100	0.37989040
82	Fanconi anemia pathway_Homo sapiens_hsa03460	0.33774637
83	ECM-receptor interaction_Homo sapiens_hsa04512	0.33651375
84	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.33619478
85	Arginine and proline metabolism_Homo sapiens_hsa00330	0.33371292
86	Allograft rejection_Homo sapiens_hsa05330	0.32526463
87	Oocyte meiosis_Homo sapiens_hsa04114	0.32313971
88	Morphine addiction_Homo sapiens_hsa05032	0.28084431
89	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.27393107
90	Tight junction_Homo sapiens_hsa04530	0.26977639
91	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.24293373
92	Graft-versus-host disease_Homo sapiens_hsa05332	0.23733671
93	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.23596685
94	Circadian entrainment_Homo sapiens_hsa04713	0.23231839
95	Folate biosynthesis_Homo sapiens_hsa00790	0.18475228
96	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.11854665
97	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.11807838
98	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.11512453
99	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.11337445
100	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.11071319

RAD17P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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