RAD17P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of mast cell activation (GO:0033004)5.06215183
2C4-dicarboxylate transport (GO:0015740)4.87405412
3presynaptic membrane assembly (GO:0097105)4.57267752
4response to pheromone (GO:0019236)4.39070124
5neurotransmitter uptake (GO:0001504)4.26645120
6regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.15772325
7platelet dense granule organization (GO:0060155)4.03746913
8regulation of glucokinase activity (GO:0033131)3.94885395
9regulation of hexokinase activity (GO:1903299)3.94885395
10establishment of protein localization to Golgi (GO:0072600)3.91487255
11regulation of heat generation (GO:0031650)3.90443032
12regulation of respiratory system process (GO:0044065)3.90439841
13negative regulation of cytosolic calcium ion concentration (GO:0051481)3.86662502
14negative regulation of protein autophosphorylation (GO:0031953)3.82120652
15DNA double-strand break processing (GO:0000729)3.77686192
16monoubiquitinated protein deubiquitination (GO:0035520)3.74023571
17positive regulation of developmental pigmentation (GO:0048087)3.69496799
18fatty acid elongation (GO:0030497)3.67775521
19signal peptide processing (GO:0006465)3.66081226
20glycerophospholipid catabolic process (GO:0046475)3.63591685
21postsynaptic membrane organization (GO:0001941)3.63134482
22positive regulation of heat generation (GO:0031652)3.58174812
23presynaptic membrane organization (GO:0097090)3.58100591
24regulation of fever generation (GO:0031620)3.54765595
25protein K11-linked deubiquitination (GO:0035871)3.49257514
26regulation of respiratory gaseous exchange (GO:0043576)3.46277678
27regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.42890736
28protein targeting to Golgi (GO:0000042)3.38066445
29cytochrome complex assembly (GO:0017004)3.31332550
30UDP-N-acetylglucosamine metabolic process (GO:0006047)3.30133270
31respiratory chain complex IV assembly (GO:0008535)3.28839021
32retrograde transport, vesicle recycling within Golgi (GO:0000301)3.26988439
33gamma-aminobutyric acid transport (GO:0015812)3.26057145
34cell wall macromolecule catabolic process (GO:0016998)3.25485281
35lung vasculature development (GO:0060426)3.22174206
36protein localization to cilium (GO:0061512)3.20494787
37negative regulation of execution phase of apoptosis (GO:1900118)3.19400818
38regulation of penile erection (GO:0060405)3.16705700
39protein targeting to lysosome (GO:0006622)3.16137323
40establishment of protein localization to vacuole (GO:0072666)3.16137323
41protein targeting to vacuole (GO:0006623)3.16137323
42protein localization to Golgi apparatus (GO:0034067)3.14762312
43positive regulation of TOR signaling (GO:0032008)3.11349509
44cellular ketone body metabolic process (GO:0046950)3.08762627
45regulation of pigment cell differentiation (GO:0050932)3.07960250
46positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.06329477
47regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.06329477
48hindbrain development (GO:0030902)3.05671319
49regulation of feeding behavior (GO:0060259)3.01148412
50regulation of protein glycosylation (GO:0060049)3.00291818
51negative regulation of circadian rhythm (GO:0042754)2.95260297
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.93413800
53cilium or flagellum-dependent cell motility (GO:0001539)2.92837057
54regulation of synapse structural plasticity (GO:0051823)2.92114728
55cilium morphogenesis (GO:0060271)2.90202970
56potassium ion export (GO:0071435)2.88400429
57L-fucose catabolic process (GO:0042355)2.86621939
58fucose catabolic process (GO:0019317)2.86621939
59L-fucose metabolic process (GO:0042354)2.86621939
60regulation of cilium movement (GO:0003352)2.84954966
61estrogen biosynthetic process (GO:0006703)2.84561176
62regulation of action potential (GO:0098900)2.83976142
63replication fork processing (GO:0031297)2.82942754
64peptidyl-histidine modification (GO:0018202)2.81946990
65positive regulation of glycolytic process (GO:0045821)2.81701386
66oxidative demethylation (GO:0070989)2.81050851
67negative regulation of translation, ncRNA-mediated (GO:0040033)2.80075838
68regulation of translation, ncRNA-mediated (GO:0045974)2.80075838
69negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.80075838
70L-amino acid import (GO:0043092)2.79456666
71neural tube formation (GO:0001841)2.77456679
72regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.77179192
73ketone body metabolic process (GO:1902224)2.76824438
74snRNA transcription (GO:0009301)2.76770776
75response to lipoprotein particle (GO:0055094)2.76735037
76relaxation of cardiac muscle (GO:0055119)2.72361183
77tryptophan catabolic process (GO:0006569)2.72295339
78indole-containing compound catabolic process (GO:0042436)2.72295339
79indolalkylamine catabolic process (GO:0046218)2.72295339
80potassium ion import (GO:0010107)2.70661484
81cell wall macromolecule metabolic process (GO:0044036)2.63944814
82DNA demethylation (GO:0080111)2.62965259
83dermatan sulfate biosynthetic process (GO:0030208)2.62365807
84negative regulation of nitric-oxide synthase activity (GO:0051001)2.60505030
85prostate gland growth (GO:0060736)2.59501999
86amine catabolic process (GO:0009310)2.59257871
87cellular biogenic amine catabolic process (GO:0042402)2.59257871
88epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.59064648
89protein complex biogenesis (GO:0070271)2.58832054
90neurotransmitter-gated ion channel clustering (GO:0072578)2.57640055
91tongue development (GO:0043586)2.57116529
92reflex (GO:0060004)2.55999128
93regulation of protein autophosphorylation (GO:0031952)2.54885394
94limb bud formation (GO:0060174)2.54856989
95regulation of neurotransmitter uptake (GO:0051580)2.53363649
96cellular response to ATP (GO:0071318)2.48567993
97positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.48073053
98regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.48073053
99vocalization behavior (GO:0071625)2.47884710
100intra-Golgi vesicle-mediated transport (GO:0006891)2.47506848

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.38359621
2POU3F2_20337985_ChIP-ChIP_501MEL_Human3.06836796
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.97983596
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.95192771
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66276939
6ZNF274_21170338_ChIP-Seq_K562_Hela2.65389143
7FUS_26573619_Chip-Seq_HEK293_Human2.62883036
8IGF1R_20145208_ChIP-Seq_DFB_Human2.54871451
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.47494615
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.44016468
11TAF15_26573619_Chip-Seq_HEK293_Human2.35859933
12AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.31817104
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31198942
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27376025
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22048135
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.20495258
17P300_19829295_ChIP-Seq_ESCs_Human2.10467914
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.08187639
19VDR_22108803_ChIP-Seq_LS180_Human2.02764951
20EWS_26573619_Chip-Seq_HEK293_Human2.00998296
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.88870359
22ER_23166858_ChIP-Seq_MCF-7_Human1.87669396
23OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85286583
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83819911
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81884134
26SMAD4_21799915_ChIP-Seq_A2780_Human1.79500114
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78074088
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.76872720
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75028386
30BCAT_22108803_ChIP-Seq_LS180_Human1.74616247
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72606714
32STAT3_23295773_ChIP-Seq_U87_Human1.69413079
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67515697
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.66369987
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.65569454
36TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.64814374
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63546023
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.62160448
39TP53_16413492_ChIP-PET_HCT116_Human1.61486286
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.59250667
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58860468
42AR_25329375_ChIP-Seq_VCAP_Human1.57112483
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53853271
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.53749650
45GATA1_22025678_ChIP-Seq_K562_Human1.53298060
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.52079785
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51197080
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.50561722
49CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.46388535
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43895782
51CBP_20019798_ChIP-Seq_JUKART_Human1.43191149
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43191149
53TP53_22573176_ChIP-Seq_HFKS_Human1.39309723
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.38947632
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38426136
56P53_22387025_ChIP-Seq_ESCs_Mouse1.38222946
57E2F1_18555785_Chip-Seq_ESCs_Mouse1.36143721
58TCF4_23295773_ChIP-Seq_U87_Human1.35987285
59CRX_20693478_ChIP-Seq_RETINA_Mouse1.32141617
60FLI1_21867929_ChIP-Seq_TH2_Mouse1.30867377
61AHR_22903824_ChIP-Seq_MCF-7_Human1.30612084
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29134817
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28842134
64STAT3_18555785_Chip-Seq_ESCs_Mouse1.27367554
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25880670
66RUNX2_22187159_ChIP-Seq_PCA_Human1.25812294
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25291818
68NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24464880
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24464880
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23769006
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23068758
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23068758
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22505475
74P300_18555785_Chip-Seq_ESCs_Mouse1.22047459
75EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.20430613
76SOX2_19829295_ChIP-Seq_ESCs_Human1.19968417
77NANOG_19829295_ChIP-Seq_ESCs_Human1.19968417
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.19346169
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.19041602
80OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19005900
81TCF4_22108803_ChIP-Seq_LS180_Human1.17260159
82CDX2_22108803_ChIP-Seq_LS180_Human1.16550120
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13781494
84SOX2_18555785_Chip-Seq_ESCs_Mouse1.13697845
85SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12939057
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12418406
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10981007
88KDM2B_26808549_Chip-Seq_REH_Human1.10157425
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.09765899
90ELK1_19687146_ChIP-ChIP_HELA_Human1.09559329
91RNF2_27304074_Chip-Seq_NSC_Mouse1.05410504
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05301686
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04727788
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03820194
95TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03070798
96TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03059135
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03017843
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02749724
99TP53_18474530_ChIP-ChIP_U2OS_Human1.02654299
100CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02152367

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy5.10699812
2MP0002254_reproductive_system_inflammat4.54425362
3MP0000569_abnormal_digit_pigmentation4.24448164
4MP0008057_abnormal_DNA_replication3.02494936
5MP0001986_abnormal_taste_sensitivity2.82212126
6MP0005367_renal/urinary_system_phenotyp2.69421621
7MP0000516_abnormal_urinary_system2.69421621
8MP0005423_abnormal_somatic_nervous2.52928723
9MP0003787_abnormal_imprinting2.51801918
10MP0000427_abnormal_hair_cycle2.51485329
11MP0003880_abnormal_central_pattern2.48673818
12MP0003195_calcinosis2.40898159
13MP0002735_abnormal_chemical_nociception2.35342040
14MP0008004_abnormal_stomach_pH2.09866981
15MP0001968_abnormal_touch/_nociception2.08639237
16MP0000383_abnormal_hair_follicle2.02653089
17MP0002837_dystrophic_cardiac_calcinosis2.01272240
18MP0010386_abnormal_urinary_bladder1.93534811
19MP0004147_increased_porphyrin_level1.79413430
20MP0008877_abnormal_DNA_methylation1.76567195
21MP0005174_abnormal_tail_pigmentation1.72341810
22MP0004043_abnormal_pH_regulation1.71209004
23MP0003136_yellow_coat_color1.67416562
24MP0005187_abnormal_penis_morphology1.64732428
25MP0009745_abnormal_behavioral_response1.63360846
26MP0000015_abnormal_ear_pigmentation1.60443537
27MP0004142_abnormal_muscle_tone1.57567494
28MP0002736_abnormal_nociception_after1.57312381
29MP0002876_abnormal_thyroid_physiology1.56643140
30MP0010678_abnormal_skin_adnexa1.56353721
31MP0002733_abnormal_thermal_nociception1.51193487
32MP0005551_abnormal_eye_electrophysiolog1.49597208
33MP0004270_analgesia1.47718869
34MP0001501_abnormal_sleep_pattern1.47157422
35MP0000613_abnormal_salivary_gland1.46643099
36MP0003011_delayed_dark_adaptation1.38702547
37MP0003718_maternal_effect1.32880574
38MP0008961_abnormal_basal_metabolism1.32536058
39MP0009046_muscle_twitch1.31970686
40MP0000372_irregular_coat_pigmentation1.30338175
41MP0009697_abnormal_copulation1.28330135
42MP0005386_behavior/neurological_phenoty1.26294736
43MP0004924_abnormal_behavior1.26294736
44MP0009780_abnormal_chondrocyte_physiolo1.26078670
45MP0002638_abnormal_pupillary_reflex1.23984835
46MP0008995_early_reproductive_senescence1.22130071
47MP0003786_premature_aging1.15257429
48MP0001970_abnormal_pain_threshold1.15165227
49MP0002295_abnormal_pulmonary_circulatio1.14880557
50MP0005075_abnormal_melanosome_morpholog1.10695633
51MP0006276_abnormal_autonomic_nervous1.06920324
52MP0001984_abnormal_olfaction1.05199704
53MP0002163_abnormal_gland_morphology1.05072417
54MP0002090_abnormal_vision1.04138273
55MP0002928_abnormal_bile_duct1.03360038
56MP0002734_abnormal_mechanical_nocicepti1.01425642
57MP0006072_abnormal_retinal_apoptosis1.00747036
58MP0008058_abnormal_DNA_repair1.00599191
59MP0005645_abnormal_hypothalamus_physiol0.99137035
60MP0002938_white_spotting0.99100887
61MP0002751_abnormal_autonomic_nervous0.98499899
62MP0003121_genomic_imprinting0.97760839
63MP0003646_muscle_fatigue0.97395187
64MP0005253_abnormal_eye_physiology0.96968604
65MP0003868_abnormal_feces_composition0.96726461
66MP0000538_abnormal_urinary_bladder0.96473861
67MP0003186_abnormal_redox_activity0.95001921
68MP0002272_abnormal_nervous_system0.94377868
69MP0000639_abnormal_adrenal_gland0.93660406
70MP0008872_abnormal_physiological_respon0.91439998
71MP0005248_abnormal_Harderian_gland0.89887967
72MP0004085_abnormal_heartbeat0.86894808
73MP0002572_abnormal_emotion/affect_behav0.86576700
74MP0001486_abnormal_startle_reflex0.86491240
75MP0001756_abnormal_urination0.85499754
76MP0005448_abnormal_energy_balance0.85240232
77MP0004133_heterotaxia0.84149513
78MP0005266_abnormal_metabolism0.80701006
79MP0002909_abnormal_adrenal_gland0.79260904
80MP0008775_abnormal_heart_ventricle0.77548470
81MP0002102_abnormal_ear_morphology0.77320307
82MP0010329_abnormal_lipoprotein_level0.76429113
83MP0003950_abnormal_plasma_membrane0.74844712
84MP0004885_abnormal_endolymph0.74631614
85MP0001324_abnormal_eye_pigmentation0.74143468
86MP0001299_abnormal_eye_distance/0.73897603
87MP0001664_abnormal_digestion0.73659735
88MP0003635_abnormal_synaptic_transmissio0.73242078
89MP0002063_abnormal_learning/memory/cond0.73029939
90MP0002064_seizures0.72434730
91MP0005171_absent_coat_pigmentation0.72341710
92MP0003937_abnormal_limbs/digits/tail_de0.71082591
93MP0001944_abnormal_pancreas_morphology0.70184249
94MP0002557_abnormal_social/conspecific_i0.68293741
95MP0003122_maternal_imprinting0.67229387
96MP0005379_endocrine/exocrine_gland_phen0.66723218
97MP0002095_abnormal_skin_pigmentation0.66567770
98MP0008873_increased_physiological_sensi0.64916556
99MP0005085_abnormal_gallbladder_physiolo0.64865411
100MP0002332_abnormal_exercise_endurance0.64552564

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)4.35458376
2Pancreatic fibrosis (HP:0100732)4.34694072
3Pancreatic cysts (HP:0001737)4.33714404
4Abnormality of midbrain morphology (HP:0002418)4.23000204
5Molar tooth sign on MRI (HP:0002419)4.23000204
6Hemiparesis (HP:0001269)4.01609726
7Aplasia/Hypoplasia of the tibia (HP:0005772)3.88356835
8Nephronophthisis (HP:0000090)3.69507690
9Hyperventilation (HP:0002883)3.50521061
10Intestinal atresia (HP:0011100)3.49553935
11Thyroiditis (HP:0100646)3.20706483
12Abnormality of the renal medulla (HP:0100957)3.12572762
13Volvulus (HP:0002580)3.10752261
14Abnormality of the renal cortex (HP:0011035)3.05358574
15Prolonged QT interval (HP:0001657)3.01986937
16Short tibia (HP:0005736)2.93032630
17Medial flaring of the eyebrow (HP:0010747)2.81546728
18Albinism (HP:0001022)2.79426808
19Genetic anticipation (HP:0003743)2.72482337
20Methylmalonic acidemia (HP:0002912)2.68094130
21Hypothermia (HP:0002045)2.63768274
22Renal cortical cysts (HP:0000803)2.63403675
23Cystic liver disease (HP:0006706)2.61240444
24Large for gestational age (HP:0001520)2.61183898
25Proximal tubulopathy (HP:0000114)2.55190688
26Progressive cerebellar ataxia (HP:0002073)2.50049560
27Aplasia/Hypoplasia of the tongue (HP:0010295)2.47218449
28Hematochezia (HP:0002573)2.46211563
29Facial diplegia (HP:0001349)2.44920008
30Abnormality of vitamin B metabolism (HP:0004340)2.40515057
31Polydipsia (HP:0001959)2.40254727
32Abnormal drinking behavior (HP:0030082)2.40254727
33Hemiplegia (HP:0002301)2.39704520
34Male pseudohermaphroditism (HP:0000037)2.39203857
35Febrile seizures (HP:0002373)2.37636937
36Tubular atrophy (HP:0000092)2.34262908
37Ketoacidosis (HP:0001993)2.32723460
38Gaze-evoked nystagmus (HP:0000640)2.30022533
39Upper limb muscle weakness (HP:0003484)2.28182488
40Genital tract atresia (HP:0001827)2.26664813
41Fair hair (HP:0002286)2.25484730
42Generalized hypopigmentation (HP:0007513)2.24330315
43Congenital primary aphakia (HP:0007707)2.21879285
44Methylmalonic aciduria (HP:0012120)2.20229751
45Chronic hepatic failure (HP:0100626)2.19288766
46Gait imbalance (HP:0002141)2.16239079
47Abnormality of vitamin metabolism (HP:0100508)2.16090543
48Aqueductal stenosis (HP:0002410)2.15305784
49Cerebellar dysplasia (HP:0007033)2.14490148
50Furrowed tongue (HP:0000221)2.13352772
51Sclerocornea (HP:0000647)2.10932014
52Vaginal atresia (HP:0000148)2.09250093
53Widely spaced teeth (HP:0000687)2.06733282
54Occipital encephalocele (HP:0002085)2.04039861
55Bile duct proliferation (HP:0001408)2.03534917
56Abnormal biliary tract physiology (HP:0012439)2.03534917
57Metaphyseal dysplasia (HP:0100255)2.03057449
58Drooling (HP:0002307)2.02970276
59Lissencephaly (HP:0001339)2.02146330
60Amyotrophic lateral sclerosis (HP:0007354)2.01538866
61Abolished electroretinogram (ERG) (HP:0000550)2.01381194
62Abnormal EKG (HP:0003115)2.01240158
63Ventricular fibrillation (HP:0001663)2.00535342
64Atonic seizures (HP:0010819)1.99763811
65Narrow forehead (HP:0000341)1.99517003
66Attenuation of retinal blood vessels (HP:0007843)1.98528674
67Polyuria (HP:0000103)1.96257589
68Hypochromic microcytic anemia (HP:0004840)1.95615073
69Abnormality of macular pigmentation (HP:0008002)1.95091802
70Abnormality of renal resorption (HP:0011038)1.94023754
71Large eyes (HP:0001090)1.93059784
72Sex reversal (HP:0012245)1.90686912
73Abnormal sex determination (HP:0012244)1.90686912
74Nephrogenic diabetes insipidus (HP:0009806)1.89379653
75Bifid tongue (HP:0010297)1.88835418
76Disproportionate short-trunk short stature (HP:0003521)1.88695180
77Retinal atrophy (HP:0001105)1.88092144
78Anencephaly (HP:0002323)1.87956405
79Hypomagnesemia (HP:0002917)1.87407616
80Epidermoid cyst (HP:0200040)1.87320945
81Anophthalmia (HP:0000528)1.87022170
82Abnormality of the ischium (HP:0003174)1.85102293
83Septate vagina (HP:0001153)1.84955651
84Excessive salivation (HP:0003781)1.80928094
85Generalized hypopigmentation of hair (HP:0011358)1.80005672
86Inability to walk (HP:0002540)1.79894199
87Poor coordination (HP:0002370)1.78605489
88Cupped ear (HP:0000378)1.77646588
89Progressive inability to walk (HP:0002505)1.73046070
90Hypoalbuminemia (HP:0003073)1.72523269
91Abnormal albumin level (HP:0012116)1.72523269
92Popliteal pterygium (HP:0009756)1.70683022
93Keratoconus (HP:0000563)1.69860105
94Increased corneal curvature (HP:0100692)1.69860105
95Abnormality of calcium-phosphate metabolism (HP:0100530)1.68974272
96Abnormality of the vitamin B12 metabolism (HP:0004341)1.68841690
97Macular degeneration (HP:0000608)1.68458468
98Hyperglycemia (HP:0003074)1.67762665
99Preaxial hand polydactyly (HP:0001177)1.67556312
100Sensory axonal neuropathy (HP:0003390)1.66732177

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.97077554
2TRIM283.37203967
3TNIK3.15968272
4INSRR2.74733603
5STK38L2.69598387
6BMPR1B2.59170620
7MKNK22.43315812
8ERBB32.21499781
9MAP4K22.20240785
10NEK12.20217283
11MAPK132.18781007
12BCR2.18106509
13TAOK12.15186041
14AKT32.04463201
15WNK31.99187312
16GRK11.97416055
17PRKD31.97410747
18PAK31.81264108
19MST41.72473365
20MAP3K41.71658455
21BRSK21.70614837
22ADRBK21.70076748
23ACVR1B1.62874817
24PLK21.48052912
25STK241.42917112
26PTK2B1.35323265
27STK381.30366993
28FGFR21.29130639
29MKNK11.28262436
30DAPK21.26381819
31SIK31.21666390
32MARK11.20808326
33STK31.16786038
34PINK11.10079272
35PRKCE0.99553997
36NUAK10.99285365
37CAMKK20.98350669
38CSNK1G10.97924865
39NLK0.96897213
40OXSR10.93464244
41STK390.90969308
42CSNK1G20.90615593
43NTRK30.87852741
44BMPR20.85297760
45WEE10.81667848
46MAP3K120.80185408
47FER0.79624678
48TRPM70.79054615
49TAOK30.77015423
50CASK0.76150275
51PRKCG0.75940654
52CSNK1G30.73914858
53MET0.73535195
54DYRK20.71508809
55PHKG10.70711287
56PHKG20.70711287
57MUSK0.70529784
58BRD40.68244592
59TGFBR10.68064607
60CHUK0.66293954
61WNK40.61465787
62STK110.58034032
63CAMK2A0.57240836
64CSNK1D0.55571633
65PRKACB0.51142634
66CSNK1A1L0.49996820
67ADRBK10.48374144
68CDK30.46154241
69FGFR10.46122775
70PIK3CA0.45789123
71KSR10.44377005
72CSNK1A10.42678134
73PRKG10.40702790
74TEC0.40287082
75PRKAA10.40127803
76PRKCZ0.38432059
77SGK20.37081519
78PIK3CG0.34132645
79CAMK40.34124180
80ZAK0.31802752
81MYLK0.30785140
82ATM0.30164036
83CSNK1E0.27175247
84ROCK10.26979734
85PRKAA20.26922501
86PLK40.26551684
87ROCK20.25480674
88PLK30.25243730
89EIF2AK30.25057582
90MINK10.24603383
91GRK50.24009546
92PRKACA0.23753301
93OBSCN0.22105674
94PRKCB0.21288703
95CAMK1G0.20473147
96PDK20.20156491
97MAPKAPK50.19528211
98SGK10.18427912
99RPS6KA30.17903137
100EGFR0.17764081

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.05173937
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.00947838
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.56219268
4Non-homologous end-joining_Homo sapiens_hsa034502.34659547
5Fatty acid elongation_Homo sapiens_hsa000622.25610927
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.17240243
7Butanoate metabolism_Homo sapiens_hsa006502.15304695
8Basal transcription factors_Homo sapiens_hsa030222.13691215
9Nicotine addiction_Homo sapiens_hsa050332.08428666
10Propanoate metabolism_Homo sapiens_hsa006402.07947083
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.05346004
12Taste transduction_Homo sapiens_hsa047422.05157829
13Circadian rhythm_Homo sapiens_hsa047102.03652578
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.77334281
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69061356
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.64794274
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64017212
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60807853
19ABC transporters_Homo sapiens_hsa020101.60016972
20Homologous recombination_Homo sapiens_hsa034401.57211987
21Insulin secretion_Homo sapiens_hsa049111.46595302
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43420090
23Phototransduction_Homo sapiens_hsa047441.40758809
24Fatty acid metabolism_Homo sapiens_hsa012121.40049220
25GABAergic synapse_Homo sapiens_hsa047271.32181274
26RNA polymerase_Homo sapiens_hsa030201.30648508
27Morphine addiction_Homo sapiens_hsa050321.28835295
28Caffeine metabolism_Homo sapiens_hsa002321.22386197
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20820232
30Mineral absorption_Homo sapiens_hsa049781.20438779
31Nitrogen metabolism_Homo sapiens_hsa009101.20052442
32Glutamatergic synapse_Homo sapiens_hsa047241.19556453
33Peroxisome_Homo sapiens_hsa041461.19260475
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18780466
35Circadian entrainment_Homo sapiens_hsa047131.12942494
36Sphingolipid metabolism_Homo sapiens_hsa006001.10166136
37Olfactory transduction_Homo sapiens_hsa047401.09302937
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06035537
39Amphetamine addiction_Homo sapiens_hsa050311.03107942
40Selenocompound metabolism_Homo sapiens_hsa004501.01760828
41Collecting duct acid secretion_Homo sapiens_hsa049661.00900536
42Ether lipid metabolism_Homo sapiens_hsa005651.00827628
43Regulation of autophagy_Homo sapiens_hsa041400.99145770
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98738238
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98512934
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.98297821
47Serotonergic synapse_Homo sapiens_hsa047260.97349919
48Fanconi anemia pathway_Homo sapiens_hsa034600.95975737
49Gastric acid secretion_Homo sapiens_hsa049710.95669466
50Linoleic acid metabolism_Homo sapiens_hsa005910.93215340
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92920229
52Vitamin B6 metabolism_Homo sapiens_hsa007500.91065775
53Dopaminergic synapse_Homo sapiens_hsa047280.87965695
54Synaptic vesicle cycle_Homo sapiens_hsa047210.87389527
55Retinol metabolism_Homo sapiens_hsa008300.86258507
56TGF-beta signaling pathway_Homo sapiens_hsa043500.84899433
57Dorso-ventral axis formation_Homo sapiens_hsa043200.84393223
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84351702
59Chemical carcinogenesis_Homo sapiens_hsa052040.77277647
60Long-term depression_Homo sapiens_hsa047300.76514473
61Tryptophan metabolism_Homo sapiens_hsa003800.76463295
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76232802
63Salivary secretion_Homo sapiens_hsa049700.73275269
64Ovarian steroidogenesis_Homo sapiens_hsa049130.72967363
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72829110
66Renin secretion_Homo sapiens_hsa049240.72571622
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71935447
68Fatty acid biosynthesis_Homo sapiens_hsa000610.64370182
69Cocaine addiction_Homo sapiens_hsa050300.63943157
70Sulfur metabolism_Homo sapiens_hsa009200.63708744
71Glutathione metabolism_Homo sapiens_hsa004800.62429721
72Oxidative phosphorylation_Homo sapiens_hsa001900.61837820
73cAMP signaling pathway_Homo sapiens_hsa040240.61076423
74beta-Alanine metabolism_Homo sapiens_hsa004100.59688460
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55956868
76Nucleotide excision repair_Homo sapiens_hsa034200.54041029
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50036979
78Purine metabolism_Homo sapiens_hsa002300.48425000
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45845382
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44570083
81Arachidonic acid metabolism_Homo sapiens_hsa005900.44346075
82p53 signaling pathway_Homo sapiens_hsa041150.44011125
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43528599
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41783758
85Lysine degradation_Homo sapiens_hsa003100.39445005
86Metabolic pathways_Homo sapiens_hsa011000.39141152
87Calcium signaling pathway_Homo sapiens_hsa040200.38718501
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38131973
89Glycerolipid metabolism_Homo sapiens_hsa005610.37131227
90N-Glycan biosynthesis_Homo sapiens_hsa005100.37013330
91One carbon pool by folate_Homo sapiens_hsa006700.35671181
92Fatty acid degradation_Homo sapiens_hsa000710.34957721
93RNA degradation_Homo sapiens_hsa030180.34513126
94Hedgehog signaling pathway_Homo sapiens_hsa043400.33896439
95Oxytocin signaling pathway_Homo sapiens_hsa049210.32427840
96Pyrimidine metabolism_Homo sapiens_hsa002400.31423131
97Thyroid hormone synthesis_Homo sapiens_hsa049180.30922918
98Axon guidance_Homo sapiens_hsa043600.29290412
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29228316
100Fat digestion and absorption_Homo sapiens_hsa049750.29080553

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