RAD18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.95106718
2kinetochore organization (GO:0051383)4.86889938
3DNA replication initiation (GO:0006270)4.85021990
4DNA unwinding involved in DNA replication (GO:0006268)4.82845051
5protein localization to kinetochore (GO:0034501)4.82154613
6telomere maintenance via semi-conservative replication (GO:0032201)4.78184977
7DNA strand elongation (GO:0022616)4.71068378
8nuclear pore complex assembly (GO:0051292)4.66808168
9nuclear pore organization (GO:0006999)4.65671959
10CENP-A containing nucleosome assembly (GO:0034080)4.56539562
11DNA replication checkpoint (GO:0000076)4.55591021
12chromatin remodeling at centromere (GO:0031055)4.55184711
13telomere maintenance via recombination (GO:0000722)4.50362283
14mitotic chromosome condensation (GO:0007076)4.46533796
15mitotic recombination (GO:0006312)4.45554344
16mitotic metaphase plate congression (GO:0007080)4.38455081
17establishment of integrated proviral latency (GO:0075713)4.35552838
18protein localization to chromosome, centromeric region (GO:0071459)4.27697397
19attachment of spindle microtubules to kinetochore (GO:0008608)4.23810281
20mitotic nuclear envelope disassembly (GO:0007077)4.18972440
21mitotic sister chromatid segregation (GO:0000070)4.17089965
22DNA replication-independent nucleosome organization (GO:0034724)4.15191241
23DNA replication-independent nucleosome assembly (GO:0006336)4.15191241
24mitotic sister chromatid cohesion (GO:0007064)4.14677097
25kinetochore assembly (GO:0051382)4.14626890
26meiotic chromosome segregation (GO:0045132)4.11360852
27metaphase plate congression (GO:0051310)4.09940591
28DNA replication-dependent nucleosome assembly (GO:0006335)4.08756402
29DNA replication-dependent nucleosome organization (GO:0034723)4.08756402
30sister chromatid segregation (GO:0000819)4.01883279
31DNA ligation (GO:0006266)4.01549629
32double-strand break repair via nonhomologous end joining (GO:0006303)3.96383242
33non-recombinational repair (GO:0000726)3.96383242
34histone exchange (GO:0043486)3.90917996
35nuclear envelope disassembly (GO:0051081)3.87890673
36membrane disassembly (GO:0030397)3.87890673
37establishment of chromosome localization (GO:0051303)3.86452902
38telomere maintenance via telomere lengthening (GO:0010833)3.83887953
39nucleotide-excision repair, DNA gap filling (GO:0006297)3.81546744
40IMP biosynthetic process (GO:0006188)3.73803888
41regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.70609646
42pore complex assembly (GO:0046931)3.67903081
43regulation of spindle organization (GO:0090224)3.63910336
44ribosome assembly (GO:0042255)3.60993000
45regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.55586071
46nucleobase biosynthetic process (GO:0046112)3.51818373
47DNA duplex unwinding (GO:0032508)3.42274406
48DNA geometric change (GO:0032392)3.42211087
49IMP metabolic process (GO:0046040)3.41819975
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.38290061
51chromosome segregation (GO:0007059)3.34219016
52translesion synthesis (GO:0019985)3.33768875
53chromatin assembly or disassembly (GO:0006333)3.32310252
54spindle checkpoint (GO:0031577)3.32225064
55regulation of centrosome cycle (GO:0046605)3.30492126
56positive regulation of chromosome segregation (GO:0051984)3.30159687
57regulation of sister chromatid cohesion (GO:0007063)3.29877904
58purine nucleobase biosynthetic process (GO:0009113)3.29453500
59establishment of viral latency (GO:0019043)3.29307468
60regulation of chromosome segregation (GO:0051983)3.28106880
61telomere maintenance (GO:0000723)3.27960554
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.27629154
63protein K6-linked ubiquitination (GO:0085020)3.25702824
64telomere organization (GO:0032200)3.25569033
65regulation of mitotic metaphase/anaphase transition (GO:0030071)3.24840856
66regulation of centriole replication (GO:0046599)3.22323228
67spindle assembly checkpoint (GO:0071173)3.22201036
68postreplication repair (GO:0006301)3.22174509
69mitotic G2/M transition checkpoint (GO:0044818)3.22172328
70heterochromatin organization (GO:0070828)3.21130089
71folic acid-containing compound biosynthetic process (GO:0009396)3.20962240
72negative regulation of chromosome segregation (GO:0051985)3.20175189
73formation of translation preinitiation complex (GO:0001731)3.20030807
74negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.19766935
75negative regulation of sister chromatid segregation (GO:0033046)3.19766935
76negative regulation of mitotic sister chromatid separation (GO:2000816)3.19766935
77negative regulation of mitotic sister chromatid segregation (GO:0033048)3.19766935
78proteasome assembly (GO:0043248)3.19749731
79deoxyribonucleotide biosynthetic process (GO:0009263)3.19207168
80regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.18651074
81protein localization to chromosome (GO:0034502)3.16955649
82regulation of DNA endoreduplication (GO:0032875)3.16879004
83DNA conformation change (GO:0071103)3.16361867
84regulation of mitotic spindle organization (GO:0060236)3.15387491
85replication fork processing (GO:0031297)3.13928328
86ATP-dependent chromatin remodeling (GO:0043044)3.13919223
87regulation of double-strand break repair via homologous recombination (GO:0010569)3.13281558
88regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.13261763
89negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11905862
90mitotic spindle assembly checkpoint (GO:0007094)3.11635043
91negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.10956581
92DNA topological change (GO:0006265)3.10358145
93G1/S transition of mitotic cell cycle (GO:0000082)3.09850895
94cell cycle G1/S phase transition (GO:0044843)3.09850895
95positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.09712211
96positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.09712211
97positive regulation of mitotic sister chromatid separation (GO:1901970)3.09712211
98chromosome condensation (GO:0030261)3.09488279
99regulation of translational fidelity (GO:0006450)3.09262978
100somatic hypermutation of immunoglobulin genes (GO:0016446)3.07984274
101somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07984274
102mitotic spindle checkpoint (GO:0071174)3.06608703
103regulation of mitotic sister chromatid separation (GO:0010965)3.06373741
104regulation of mitotic sister chromatid segregation (GO:0033047)3.06373741
105regulation of sister chromatid segregation (GO:0033045)3.06373741
106DNA packaging (GO:0006323)3.05221568
107ribosomal small subunit assembly (GO:0000028)3.03583689
108regulation of histone H3-K9 methylation (GO:0051570)3.03455434
109mismatch repair (GO:0006298)3.03407652
110mitotic cell cycle (GO:0000278)2.98553330
111maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.96551277
112maturation of SSU-rRNA (GO:0030490)2.95306850
113DNA synthesis involved in DNA repair (GO:0000731)2.93136733
114nuclear envelope organization (GO:0006998)2.92284417
115regulation of nuclear cell cycle DNA replication (GO:0033262)2.89062338
116regulation of mitotic spindle checkpoint (GO:1903504)2.88913582
117regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.88913582
118chromosome organization (GO:0051276)2.88488362

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.24021658
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.55272068
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.79522013
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.66882895
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.07122578
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.86024823
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.70220646
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.59764168
9* EST1_17652178_ChIP-ChIP_JURKAT_Human2.59672925
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54878837
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.54496574
12AR_21909140_ChIP-Seq_LNCAP_Human2.52323071
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.43567286
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.40084355
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36847985
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34446202
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.26738416
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.20495665
19* ETS1_20019798_ChIP-Seq_JURKAT_Human2.13035044
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12488920
21VDR_23849224_ChIP-Seq_CD4+_Human2.10511314
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04132653
23XRN2_22483619_ChIP-Seq_HELA_Human2.03866213
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00348726
25E2F7_22180533_ChIP-Seq_HELA_Human11.0508153
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98405210
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95229746
28FOXP3_21729870_ChIP-Seq_TREG_Human1.92220266
29* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86980216
30* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85600333
31ELK1_19687146_ChIP-ChIP_HELA_Human1.82628078
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82395376
33DCP1A_22483619_ChIP-Seq_HELA_Human1.80226311
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74150971
35TTF2_22483619_ChIP-Seq_HELA_Human1.68228647
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67075014
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65181716
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61024353
39GABP_19822575_ChIP-Seq_HepG2_Human1.59832231
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57265527
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56107814
42* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55513168
43CIITA_25753668_ChIP-Seq_RAJI_Human1.52630457
44MYC_22102868_ChIP-Seq_BL_Human1.49431217
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49115898
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48513556
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44027490
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43557558
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43539017
50* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43462958
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40165634
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36023062
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34530789
54KDM5A_27292631_Chip-Seq_BREAST_Human1.33476306
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.33468815
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30524695
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26165465
58E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25355144
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.21224197
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18466563
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18120052
62TFEB_21752829_ChIP-Seq_HELA_Human1.17745625
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13554329
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.11710270
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.11591706
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11516102
67* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10815419
68* SRF_21415370_ChIP-Seq_HL-1_Mouse1.09923530
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05225993
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03343440
71MYC_18940864_ChIP-ChIP_HL60_Human0.98765944
72SPI1_23547873_ChIP-Seq_NB4_Human0.98747293
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97473963
74SOX17_20123909_ChIP-Seq_XEN_Mouse0.95972341
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92895213
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92213777
77SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91789987
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91331284
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89612141
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89186147
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88181749
82ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87891702
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87889127
84MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86200366
85VDR_21846776_ChIP-Seq_THP-1_Human0.85956888
86CHD1_26751641_Chip-Seq_LNCaP_Human0.84694464
87STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83978051
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82687808
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.80858802
90* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80401979
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80134895
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.79615018
93MYB_26560356_Chip-Seq_TH2_Human0.78510391
94SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.78403402
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78202026
96HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77853851
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77568465
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76890895
99MYB_26560356_Chip-Seq_TH1_Human0.76871002
100* NANOG_16153702_ChIP-ChIP_HESCs_Human0.76453172
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.75978776
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73725492
103KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.73616121
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73071118
105MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.72547387
106PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.71428224
107STAT4_19710469_ChIP-ChIP_TH1__Mouse0.70860464
108NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.69335407
109* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.68946084
110NANOG_21062744_ChIP-ChIP_HESCs_Human0.68895886
111TBX5_21415370_ChIP-Seq_HL-1_Mouse0.67123303
112* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.66930613
113SOX2_16153702_ChIP-ChIP_HESCs_Human0.66657689

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.15141755
2MP0003693_abnormal_embryo_hatching4.76132699
3MP0008057_abnormal_DNA_replication4.53848290
4MP0003111_abnormal_nucleus_morphology4.35611186
5MP0003077_abnormal_cell_cycle3.96018585
6MP0004957_abnormal_blastocyst_morpholog3.90571562
7MP0008058_abnormal_DNA_repair3.48181474
8MP0008877_abnormal_DNA_methylation3.33801323
9MP0008007_abnormal_cellular_replicative2.97438520
10MP0002396_abnormal_hematopoietic_system2.72513993
11MP0008932_abnormal_embryonic_tissue2.46195606
12MP0010307_abnormal_tumor_latency2.38267588
13MP0010352_gastrointestinal_tract_polyps2.30066523
14MP0000350_abnormal_cell_proliferation2.14734675
15MP0003123_paternal_imprinting2.08674886
16MP0001730_embryonic_growth_arrest2.06773052
17MP0004808_abnormal_hematopoietic_stem2.03273454
18MP0003786_premature_aging1.87844940
19MP0003806_abnormal_nucleotide_metabolis1.70542057
20MP0000490_abnormal_crypts_of1.67627161
21MP0003763_abnormal_thymus_physiology1.61271178
22MP0003941_abnormal_skin_development1.60213192
23* MP0002210_abnormal_sex_determination1.56939922
24MP0001672_abnormal_embryogenesis/_devel1.56140928
25MP0005380_embryogenesis_phenotype1.56140928
26MP0001697_abnormal_embryo_size1.55394890
27MP0003121_genomic_imprinting1.49120624
28MP0002019_abnormal_tumor_incidence1.47505397
29MP0003984_embryonic_growth_retardation1.43706537
30MP0000313_abnormal_cell_death1.43368522
31MP0006292_abnormal_olfactory_placode1.42829135
32MP0002009_preneoplasia1.38898981
33MP0002088_abnormal_embryonic_growth/wei1.38789380
34MP0002080_prenatal_lethality1.37930440
35MP0005076_abnormal_cell_differentiation1.37610271
36MP0004197_abnormal_fetal_growth/weight/1.34702778
37MP0005397_hematopoietic_system_phenotyp1.33544750
38MP0001545_abnormal_hematopoietic_system1.33544750
39MP0002085_abnormal_embryonic_tissue1.32539558
40* MP0001929_abnormal_gametogenesis1.32173868
41MP0002398_abnormal_bone_marrow1.31910039
42MP0000703_abnormal_thymus_morphology1.31886657
43MP0006054_spinal_hemorrhage1.31879592
44* MP0001145_abnormal_male_reproductive1.28652576
45MP0004233_abnormal_muscle_weight1.26729736
46MP0002084_abnormal_developmental_patter1.26121416
47MP0002086_abnormal_extraembryonic_tissu1.25158990
48MP0009333_abnormal_splenocyte_physiolog1.21035078
49MP0006035_abnormal_mitochondrial_morpho1.18153173
50MP0003718_maternal_effect1.13560423
51* MP0000653_abnormal_sex_gland1.13440284
52MP0000569_abnormal_digit_pigmentation1.13309501
53MP0002722_abnormal_immune_system1.10080994
54MP0000689_abnormal_spleen_morphology1.09342365
55MP0001853_heart_inflammation1.08103608
56MP0003567_abnormal_fetal_cardiomyocyte1.06198892
57MP0005408_hypopigmentation1.06194485
58MP0000372_irregular_coat_pigmentation1.05133421
59MP0001293_anophthalmia1.03578047
60MP0003950_abnormal_plasma_membrane1.02012548
61MP0003890_abnormal_embryonic-extraembry1.00206503
62MP0002697_abnormal_eye_size0.98198547
63MP0001119_abnormal_female_reproductive0.96577034
64MP0003315_abnormal_perineum_morphology0.95931061
65MP0002429_abnormal_blood_cell0.94073114
66MP0003705_abnormal_hypodermis_morpholog0.93539936
67MP0001286_abnormal_eye_development0.92725220
68MP0004185_abnormal_adipocyte_glucose0.90348906
69MP0001915_intracranial_hemorrhage0.88006342
70MP0002234_abnormal_pharynx_morphology0.87174024
71MP0000858_altered_metastatic_potential0.86258073
72MP0000716_abnormal_immune_system0.85546461
73MP0002095_abnormal_skin_pigmentation0.85139989
74MP0000537_abnormal_urethra_morphology0.85001324
75MP0001835_abnormal_antigen_presentation0.84712548
76MP0009697_abnormal_copulation0.83948917
77MP0003221_abnormal_cardiomyocyte_apopto0.82537134
78MP0002160_abnormal_reproductive_system0.81337090
79MP0001800_abnormal_humoral_immune0.81125543
80MP0009672_abnormal_birth_weight0.80290894
81MP0005671_abnormal_response_to0.80226731
82MP0005023_abnormal_wound_healing0.79708039
83MP0000015_abnormal_ear_pigmentation0.79309046
84MP0005621_abnormal_cell_physiology0.79161483
85MP0002006_tumorigenesis0.78989528
86MP0010030_abnormal_orbit_morphology0.78850901
87MP0001661_extended_life_span0.78532286
88MP0005174_abnormal_tail_pigmentation0.78292335
89MP0002420_abnormal_adaptive_immunity0.78259948
90MP0002092_abnormal_eye_morphology0.77544629
91MP0005384_cellular_phenotype0.77512967
92MP0003787_abnormal_imprinting0.77092122
93MP0001819_abnormal_immune_cell0.75889900
94MP0005501_abnormal_skin_physiology0.75123406
95MP0002452_abnormal_antigen_presenting0.74212094
96MP0006036_abnormal_mitochondrial_physio0.73924348
97* MP0003698_abnormal_male_reproductive0.73268972
98MP0009703_decreased_birth_body0.71569959
99MP0003937_abnormal_limbs/digits/tail_de0.71374425
100MP0003943_abnormal_hepatobiliary_system0.70997869
101MP0009053_abnormal_anal_canal0.70789875
102MP0002166_altered_tumor_susceptibility0.69867837
103MP0003566_abnormal_cell_adhesion0.69332653
104MP0002405_respiratory_system_inflammati0.68992629
105MP0005395_other_phenotype0.68571279
106MP0003699_abnormal_female_reproductive0.67840456
107MP0003448_altered_tumor_morphology0.67532806
108MP0002075_abnormal_coat/hair_pigmentati0.66545532
109MP0001727_abnormal_embryo_implantation0.66507877
110MP0001873_stomach_inflammation0.65885653
111MP0005389_reproductive_system_phenotype0.63049116
112MP0001243_abnormal_dermal_layer0.61445524
113MP0002111_abnormal_tail_morphology0.61090007
114MP0000358_abnormal_cell_content/0.60687064
115MP0002060_abnormal_skin_morphology0.60231454
116MP0002723_abnormal_immune_serum0.60180352
117MP0002233_abnormal_nose_morphology0.60113501
118MP0009278_abnormal_bone_marrow0.59645501
119MP0000428_abnormal_craniofacial_morphol0.58233097
120MP0000627_abnormal_mammary_gland0.57920978
121MP0003935_abnormal_craniofacial_develop0.57857136
122MP0001881_abnormal_mammary_gland0.57450278
123MP0000432_abnormal_head_morphology0.57095675
124* MP0002161_abnormal_fertility/fecundity0.54740314
125MP0002877_abnormal_melanocyte_morpholog0.54664347
126MP0000371_diluted_coat_color0.54347214
127MP0001216_abnormal_epidermal_layer0.54287271
128MP0002938_white_spotting0.54243606
129MP0001346_abnormal_lacrimal_gland0.54180005
130MP0000647_abnormal_sebaceous_gland0.53618036
131MP0003385_abnormal_body_wall0.52809405
132MP0005075_abnormal_melanosome_morpholog0.52605633
133MP0003186_abnormal_redox_activity0.52584412
134MP0008770_decreased_survivor_rate0.51203123
135MP0003861_abnormal_nervous_system0.51056634
136MP0002970_abnormal_white_adipose0.49302519

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.00491512
2Chromsome breakage (HP:0040012)4.89838014
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.42541566
4Abnormality of chromosome stability (HP:0003220)3.93157929
5Selective tooth agenesis (HP:0001592)3.71522608
6Meckel diverticulum (HP:0002245)3.38452343
7Abnormality of the preputium (HP:0100587)3.34118941
8Reticulocytopenia (HP:0001896)3.25905794
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.24390536
10Abnormality of the ileum (HP:0001549)3.23041469
1111 pairs of ribs (HP:0000878)3.11004887
12Myelodysplasia (HP:0002863)3.08509716
13Medulloblastoma (HP:0002885)3.06751136
14Colon cancer (HP:0003003)3.05910012
15Volvulus (HP:0002580)2.97055289
16Small intestinal stenosis (HP:0012848)2.95970689
17Duodenal stenosis (HP:0100867)2.95970689
18Ectopic kidney (HP:0000086)2.95023254
19Degeneration of anterior horn cells (HP:0002398)2.94779273
20Abnormality of the anterior horn cell (HP:0006802)2.94779273
21Breast hypoplasia (HP:0003187)2.91642304
22Patellar aplasia (HP:0006443)2.87303920
23Aplasia/Hypoplasia of the sacrum (HP:0008517)2.85189680
24Aplastic anemia (HP:0001915)2.82521926
25Agnosia (HP:0010524)2.78602715
26Microvesicular hepatic steatosis (HP:0001414)2.73816727
27Cortical dysplasia (HP:0002539)2.68661505
28Impulsivity (HP:0100710)2.66507136
29Aplasia/Hypoplasia of the patella (HP:0006498)2.61809317
30Increased nuchal translucency (HP:0010880)2.60368013
31Sloping forehead (HP:0000340)2.53429628
32Oral leukoplakia (HP:0002745)2.51433379
33Rhabdomyosarcoma (HP:0002859)2.48261184
34Ependymoma (HP:0002888)2.45261723
35Absent thumb (HP:0009777)2.44537277
36Short middle phalanx of the 5th finger (HP:0004220)2.42287439
37Bone marrow hypocellularity (HP:0005528)2.41764359
38Abnormality of the carotid arteries (HP:0005344)2.40396469
39Abnormal lung lobation (HP:0002101)2.39472954
40Multiple enchondromatosis (HP:0005701)2.37126939
41Abnormality of glycolysis (HP:0004366)2.36930340
42Nephroblastoma (Wilms tumor) (HP:0002667)2.36491171
43Overlapping toe (HP:0001845)2.36437501
44Hypoplasia of the capital femoral epiphysis (HP:0003090)2.35360843
45Abnormality of the duodenum (HP:0002246)2.34510374
46Premature graying of hair (HP:0002216)2.31355218
47Clubbing of toes (HP:0100760)2.30403730
48Carpal bone hypoplasia (HP:0001498)2.29905102
49Acute myeloid leukemia (HP:0004808)2.29249318
50Abnormal spermatogenesis (HP:0008669)2.29110880
51Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.26891280
52Short 4th metacarpal (HP:0010044)2.26891280
53Duplicated collecting system (HP:0000081)2.24038014
54Deviation of the thumb (HP:0009603)2.23903675
55Abnormality of DNA repair (HP:0003254)2.23402374
56Proximal placement of thumb (HP:0009623)2.23231393
57Embryonal renal neoplasm (HP:0011794)2.22456859
58Basal cell carcinoma (HP:0002671)2.21419329
59Abnormal number of incisors (HP:0011064)2.18792814
60Cafe-au-lait spot (HP:0000957)2.18270549
61High pitched voice (HP:0001620)2.17540300
62Absent radius (HP:0003974)2.16764147
63Prominent nose (HP:0000448)2.16312700
64Progressive muscle weakness (HP:0003323)2.15795591
65Abnormality of cochlea (HP:0000375)2.13161253
66Abnormality of the fingertips (HP:0001211)2.12492858
67Amaurosis fugax (HP:0100576)2.11315654
68Neoplasm of the pancreas (HP:0002894)2.10382104
69Increased serum pyruvate (HP:0003542)2.10127884
70Abnormality of methionine metabolism (HP:0010901)2.07633312
71Abnormal number of erythroid precursors (HP:0012131)2.06505049
72Choanal atresia (HP:0000453)2.06210187
73Abnormality of the labia minora (HP:0012880)2.05519629
74Abnormality of cells of the erythroid lineage (HP:0012130)2.02613414
75Abnormality of the renal collecting system (HP:0004742)2.00229398
76Lymphoma (HP:0002665)1.99814875
77Pancytopenia (HP:0001876)1.98946218
78Absent forearm bone (HP:0003953)1.98006303
79Aplasia involving forearm bones (HP:0009822)1.98006303
80Thrombocytosis (HP:0001894)1.97699965
81Long eyelashes (HP:0000527)1.97571372
82Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.97370161
83Absent epiphyses (HP:0010577)1.97370161
84Abnormality of the columella (HP:0009929)1.96752280
85Tracheoesophageal fistula (HP:0002575)1.96608931
86Cholecystitis (HP:0001082)1.96370167
87Abnormal gallbladder physiology (HP:0012438)1.96370167
88Aplasia/Hypoplasia of the earlobes (HP:0009906)1.96216640
89Arteriovenous malformation (HP:0100026)1.94134664
90Irregular epiphyses (HP:0010582)1.93914466
91Rough bone trabeculation (HP:0100670)1.92757859
92Missing ribs (HP:0000921)1.90920492
93Abnormal umbilical cord blood vessels (HP:0011403)1.90899957
94Single umbilical artery (HP:0001195)1.90899957
95Abnormality of the fetal cardiovascular system (HP:0010948)1.90899957
96Triphalangeal thumb (HP:0001199)1.90829299
97Atresia of the external auditory canal (HP:0000413)1.90827346
98IgM deficiency (HP:0002850)1.90006447
99Cellular immunodeficiency (HP:0005374)1.88913903
100Squamous cell carcinoma (HP:0002860)1.88879212
101Slender long bone (HP:0003100)1.87332956
102Supernumerary spleens (HP:0009799)1.87022197
103Facial cleft (HP:0002006)1.87004759
104Short thumb (HP:0009778)1.86440727
105Microglossia (HP:0000171)1.84921641
106Embryonal neoplasm (HP:0002898)1.84571248
107Secondary amenorrhea (HP:0000869)1.84422085
108Neoplasm of the colon (HP:0100273)1.83808656
109Deep philtrum (HP:0002002)1.83292122
110Progressive external ophthalmoplegia (HP:0000590)1.80807067
111Hypoplastic pelvis (HP:0008839)1.80662763
112Aplasia/Hypoplasia of the sternum (HP:0006714)1.79600369
113Poikiloderma (HP:0001029)1.78456056
114Pallor (HP:0000980)1.78273111
115Premature ovarian failure (HP:0008209)1.77910752
116Abnormality of the umbilical cord (HP:0010881)1.77201241
117Macrocytic anemia (HP:0001972)1.76923524
118Sandal gap (HP:0001852)1.76876892
119Abnormality of chromosome segregation (HP:0002916)1.74167536
120Cutaneous melanoma (HP:0012056)1.73606272
121Abnormality of pyrimidine metabolism (HP:0004353)1.72919538
122Optic nerve coloboma (HP:0000588)1.72790936
123Glioma (HP:0009733)1.71468909
124Horseshoe kidney (HP:0000085)1.70042861
125Facial hemangioma (HP:0000329)1.69749616
126Pulmonary fibrosis (HP:0002206)1.69607051
127Neoplasm of striated muscle (HP:0009728)1.68795569
128Acute lymphatic leukemia (HP:0006721)1.68502033
129Broad palm (HP:0001169)1.67271201
130Astrocytoma (HP:0009592)1.67200971
131Abnormality of the astrocytes (HP:0100707)1.67200971
132Biliary tract neoplasm (HP:0100574)1.66712022
133High anterior hairline (HP:0009890)1.65326784
134Partial agenesis of the corpus callosum (HP:0001338)1.61006711
135Entropion (HP:0000621)1.57806518

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* CDC74.95833043
2WEE14.12589977
3BUB13.73079581
4ACVR1B2.95910326
5NEK22.90158165
6EIF2AK12.81993690
7SRPK12.54634563
8BRSK22.53435282
9TTK2.41394383
10NEK12.36212893
11VRK22.28710328
12PLK42.26903474
13CDK122.26037447
14ATR2.11231840
15PLK12.11009261
16MKNK12.02702833
17VRK11.91433155
18AURKB1.87719319
19EIF2AK31.87154061
20TSSK61.79333110
21MST41.78443114
22PASK1.76707755
23PLK31.72946819
24CDK71.71052077
25BRSK11.64033431
26STK101.61385479
27RPS6KA41.58468882
28CHEK21.56306311
29CCNB11.54495855
30TAF11.53639959
31CHEK11.41197695
32CDK41.39113650
33SCYL21.37625732
34TLK11.36334480
35STK41.34458535
36BRD41.31169694
37MKNK21.29941418
38SMG11.29746803
39TGFBR11.26516001
40TESK21.14914208
41ZAK1.12823644
42* ATM1.11994000
43MAP4K11.11293532
44MAP3K81.11257891
45RPS6KB21.08094718
46EEF2K1.07014541
47AURKA1.05555789
48CDK61.05491455
49NME21.05302853
50DYRK31.01878797
51MELK1.00529452
52STK161.00296615
53CLK10.99620481
54CDK80.99097530
55PAK40.96611263
56TRIM280.95777820
57PIM10.95677929
58NME10.91748733
59* CDK20.91722848
60EIF2AK20.89033616
61STK30.88583082
62PDK20.88043289
63MST1R0.87663434
64PBK0.82179565
65TEC0.80924685
66CDK10.78184706
67TXK0.78151398
68TESK10.77023129
69ERBB40.74201077
70JAK30.69316047
71PNCK0.63417343
72CSNK2A10.61315226
73NEK90.61229378
74CSNK2A20.60579504
75FLT30.58776733
76BTK0.58517914
77PIM20.52854596
78RPS6KA50.51658402
79CDK30.51419275
80PDK30.49210161
81PDK40.49210161
82LRRK20.48106813
83IRAK30.46014558
84STK240.44337828
85IRAK40.43387159
86NUAK10.42754273
87PAK10.41679786
88ALK0.40318481
89MAP3K100.39703734
90CSNK1E0.39689467
91PRKDC0.39449342
92KIT0.39068112
93DAPK10.38817569
94BRAF0.37905819
95MET0.36967339
96ICK0.34527072
97RAF10.34271114
98MAPK140.34186259
99ERBB30.34043830
100MARK30.34043045
101LATS10.33718864
102CDK180.33524472
103ZAP700.33276103
104RPS6KB10.31556184
105CDK150.31314966
106CHUK0.31291399
107MTOR0.31107674
108AKT20.30592965
109MAPKAPK50.29459935
110CDK11A0.29002509
111CDK140.27964689
112CAMK1G0.27695687
113STK38L0.27523140
114ITK0.27437154
115YES10.26427289
116CSF1R0.26371116
117ILK0.26113790
118CSNK1A1L0.25654534
119MAPK10.24827747
120EPHA20.24485382
121TYK20.24236603
122BMPR1B0.23983924
123CDK90.23934432
124LYN0.23603113
125AKT10.23467977
126KDR0.23188244
127CSNK1G10.23184304
128PAK20.22658508
129CAMK1D0.22473832
130CSNK1D0.22164852
131FGFR10.17987290
132PLK20.17516747

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.29495686
2Mismatch repair_Homo sapiens_hsa034304.40778786
3Homologous recombination_Homo sapiens_hsa034403.45777859
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.31425548
5Base excision repair_Homo sapiens_hsa034103.22107603
6Cell cycle_Homo sapiens_hsa041103.17513975
7Spliceosome_Homo sapiens_hsa030402.94790670
8RNA transport_Homo sapiens_hsa030132.92083557
9Nucleotide excision repair_Homo sapiens_hsa034202.91026179
10Fanconi anemia pathway_Homo sapiens_hsa034602.72558415
11Non-homologous end-joining_Homo sapiens_hsa034502.68305895
12One carbon pool by folate_Homo sapiens_hsa006702.50571691
13RNA polymerase_Homo sapiens_hsa030202.39329131
14Proteasome_Homo sapiens_hsa030502.38918094
15Ribosome_Homo sapiens_hsa030102.13687268
16Pyrimidine metabolism_Homo sapiens_hsa002402.13403495
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13148790
18Basal transcription factors_Homo sapiens_hsa030222.02527426
19RNA degradation_Homo sapiens_hsa030182.01275792
20p53 signaling pathway_Homo sapiens_hsa041151.79976100
21mRNA surveillance pathway_Homo sapiens_hsa030151.79049445
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53367440
23Systemic lupus erythematosus_Homo sapiens_hsa053221.37836013
24Herpes simplex infection_Homo sapiens_hsa051681.24125389
25Epstein-Barr virus infection_Homo sapiens_hsa051691.22549163
26Antigen processing and presentation_Homo sapiens_hsa046121.21808224
27Viral carcinogenesis_Homo sapiens_hsa052031.16271897
28Pyruvate metabolism_Homo sapiens_hsa006201.16140154
29Purine metabolism_Homo sapiens_hsa002301.14635048
30Oocyte meiosis_Homo sapiens_hsa041141.10993006
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03888892
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02238404
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01376742
34Carbon metabolism_Homo sapiens_hsa012000.98825395
35HTLV-I infection_Homo sapiens_hsa051660.97377856
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94504260
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93931071
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93926271
39Small cell lung cancer_Homo sapiens_hsa052220.85548789
40MicroRNAs in cancer_Homo sapiens_hsa052060.85319392
41Primary immunodeficiency_Homo sapiens_hsa053400.83436934
42Measles_Homo sapiens_hsa051620.80135694
43Huntingtons disease_Homo sapiens_hsa050160.77333420
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74813034
45Legionellosis_Homo sapiens_hsa051340.73496648
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.71674632
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70133469
48Steroid biosynthesis_Homo sapiens_hsa001000.68823673
49Parkinsons disease_Homo sapiens_hsa050120.68073174
50Fatty acid elongation_Homo sapiens_hsa000620.67139665
51Thyroid cancer_Homo sapiens_hsa052160.64885808
52Hepatitis B_Homo sapiens_hsa051610.64169132
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63146536
54Apoptosis_Homo sapiens_hsa042100.62760323
55Propanoate metabolism_Homo sapiens_hsa006400.61611855
56Sulfur relay system_Homo sapiens_hsa041220.59420594
57Selenocompound metabolism_Homo sapiens_hsa004500.59211993
58Allograft rejection_Homo sapiens_hsa053300.57503554
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57218391
60Hematopoietic cell lineage_Homo sapiens_hsa046400.57033527
61Vitamin B6 metabolism_Homo sapiens_hsa007500.56892782
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56136188
63Protein export_Homo sapiens_hsa030600.55974804
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54756313
65Pentose phosphate pathway_Homo sapiens_hsa000300.54094382
66Oxidative phosphorylation_Homo sapiens_hsa001900.53859237
67TGF-beta signaling pathway_Homo sapiens_hsa043500.53271683
68Colorectal cancer_Homo sapiens_hsa052100.53099962
69Influenza A_Homo sapiens_hsa051640.50831958
70N-Glycan biosynthesis_Homo sapiens_hsa005100.50829593
71Viral myocarditis_Homo sapiens_hsa054160.50776691
72Shigellosis_Homo sapiens_hsa051310.49534871
73Alcoholism_Homo sapiens_hsa050340.46303521
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46302239
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45462924
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45070185
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44966599
78Leishmaniasis_Homo sapiens_hsa051400.44259948
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.43180902
80Chronic myeloid leukemia_Homo sapiens_hsa052200.43131294
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.43073367
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40467906
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37392132
84Pancreatic cancer_Homo sapiens_hsa052120.37310051
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36792572
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36162980
87Graft-versus-host disease_Homo sapiens_hsa053320.35641307
88Metabolic pathways_Homo sapiens_hsa011000.35590543
89Non-small cell lung cancer_Homo sapiens_hsa052230.35528175
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35431387
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34697125
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.34528107
93T cell receptor signaling pathway_Homo sapiens_hsa046600.34479423
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.31905078
95Pathways in cancer_Homo sapiens_hsa052000.31853381
96Lysine degradation_Homo sapiens_hsa003100.30562410
97Toxoplasmosis_Homo sapiens_hsa051450.29508125
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29289003
99Galactose metabolism_Homo sapiens_hsa000520.28596657
100Prostate cancer_Homo sapiens_hsa052150.27566910
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27535203
102B cell receptor signaling pathway_Homo sapiens_hsa046620.26805039
103Hippo signaling pathway_Homo sapiens_hsa043900.26727270
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26503203
105Adherens junction_Homo sapiens_hsa045200.26258994
106Alzheimers disease_Homo sapiens_hsa050100.26255868
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26017378
108Biosynthesis of amino acids_Homo sapiens_hsa012300.25917974
109Asthma_Homo sapiens_hsa053100.25722818
110Notch signaling pathway_Homo sapiens_hsa043300.25546955
111HIF-1 signaling pathway_Homo sapiens_hsa040660.25464803
112Basal cell carcinoma_Homo sapiens_hsa052170.25019322
113Melanoma_Homo sapiens_hsa052180.24874738
114Type I diabetes mellitus_Homo sapiens_hsa049400.24310299
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.24128463
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.23863682
117Acute myeloid leukemia_Homo sapiens_hsa052210.23794229
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23353380
119Fructose and mannose metabolism_Homo sapiens_hsa000510.22689513
120Autoimmune thyroid disease_Homo sapiens_hsa053200.22061804
121Folate biosynthesis_Homo sapiens_hsa007900.21737190
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21216392
123Sulfur metabolism_Homo sapiens_hsa009200.20425133
124Renin-angiotensin system_Homo sapiens_hsa046140.19704466
125FoxO signaling pathway_Homo sapiens_hsa040680.18946852
126Malaria_Homo sapiens_hsa051440.18903757
127Wnt signaling pathway_Homo sapiens_hsa043100.18591352
128Bladder cancer_Homo sapiens_hsa052190.18316350
129Glutathione metabolism_Homo sapiens_hsa004800.17246477
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16864308
131TNF signaling pathway_Homo sapiens_hsa046680.16616903
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.16616030
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.16314277
134Fatty acid metabolism_Homo sapiens_hsa012120.14857031
135Glioma_Homo sapiens_hsa052140.09659611
136Renal cell carcinoma_Homo sapiens_hsa052110.03923749

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