RAD1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleoside diphosphate catabolic process (GO:0009134)9.53956913
2pyrimidine nucleotide catabolic process (GO:0006244)8.41470646
3sequestering of actin monomers (GO:0042989)6.75759454
4regulation of somitogenesis (GO:0014807)5.92811577
5meiosis I (GO:0007127)5.31641284
6water-soluble vitamin biosynthetic process (GO:0042364)5.07211535
7mismatch repair (GO:0006298)5.06651680
8endothelial tube morphogenesis (GO:0061154)4.98387104
9morphogenesis of an endothelium (GO:0003159)4.98387104
10protein-cofactor linkage (GO:0018065)4.94108775
11reciprocal DNA recombination (GO:0035825)4.69062684
12reciprocal meiotic recombination (GO:0007131)4.69062684
13pyrimidine nucleoside catabolic process (GO:0046135)4.64747538
14positive regulation of embryonic development (GO:0040019)4.42625749
15positive regulation of gastrulation (GO:2000543)4.38511612
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.30537914
17positive regulation of triglyceride biosynthetic process (GO:0010867)4.16087919
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.10806351
19positive regulation of endothelial cell differentiation (GO:0045603)4.07527570
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.93637726
21resolution of meiotic recombination intermediates (GO:0000712)3.91828829
22male meiosis (GO:0007140)3.78188310
23regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.76475346
24ribonucleoside diphosphate metabolic process (GO:0009185)3.65786645
25isoprenoid biosynthetic process (GO:0008299)3.62574530
26nucleoside transmembrane transport (GO:1901642)3.60009366
27negative regulation of membrane potential (GO:0045837)3.56641792
28response to pheromone (GO:0019236)3.50253088
29DNA deamination (GO:0045006)3.50060749
30synaptonemal complex assembly (GO:0007130)3.49648049
31synaptonemal complex organization (GO:0070193)3.49231341
32mitochondrial RNA metabolic process (GO:0000959)3.48457931
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.48348907
34purine deoxyribonucleotide catabolic process (GO:0009155)3.48278970
35regulation of endothelial cell differentiation (GO:0045601)3.46106766
36mannosylation (GO:0097502)3.43389393
37spermatid nucleus differentiation (GO:0007289)3.40409715
38mitochondrial respiratory chain complex assembly (GO:0033108)3.33602860
39maturation of 5.8S rRNA (GO:0000460)3.32807280
40pyrimidine ribonucleoside metabolic process (GO:0046131)3.32106868
41kinetochore assembly (GO:0051382)3.29474748
42respiratory electron transport chain (GO:0022904)3.29025981
43electron transport chain (GO:0022900)3.26440377
44pyrimidine-containing compound catabolic process (GO:0072529)3.24452360
45DNA damage response, detection of DNA damage (GO:0042769)3.23211466
46negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.22429900
47pyrimidine ribonucleotide metabolic process (GO:0009218)3.21308714
48dopamine transport (GO:0015872)3.18385345
49kynurenine metabolic process (GO:0070189)3.18014665
50energy coupled proton transport, down electrochemical gradient (GO:0015985)3.17760346
51ATP synthesis coupled proton transport (GO:0015986)3.17760346
52ribosomal large subunit biogenesis (GO:0042273)3.14912767
53cytidine deamination (GO:0009972)3.12846701
54cytidine metabolic process (GO:0046087)3.12846701
55cytidine catabolic process (GO:0006216)3.12846701
56dorsal/ventral neural tube patterning (GO:0021904)3.10072847
57regulation of isotype switching to IgG isotypes (GO:0048302)3.08868486
58mitochondrion morphogenesis (GO:0070584)3.07631855
59male meiosis I (GO:0007141)3.05329954
60autophagic vacuole fusion (GO:0000046)3.01968417
61transmission of nerve impulse (GO:0019226)3.00890497
62endocrine pancreas development (GO:0031018)3.00082582
63chromosome organization involved in meiosis (GO:0070192)2.95832873
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.89442881
65somite rostral/caudal axis specification (GO:0032525)2.89150400
66folic acid-containing compound biosynthetic process (GO:0009396)2.85478465
67arginine metabolic process (GO:0006525)2.84667302
68regulation of triglyceride biosynthetic process (GO:0010866)2.81475578
69DNA catabolic process, exonucleolytic (GO:0000738)2.80942121
70tryptophan catabolic process (GO:0006569)2.80040222
71indole-containing compound catabolic process (GO:0042436)2.80040222
72indolalkylamine catabolic process (GO:0046218)2.80040222
73DNA double-strand break processing (GO:0000729)2.78159798
74protein complex biogenesis (GO:0070271)2.75383316
75CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.73460555
76behavioral response to nicotine (GO:0035095)2.68671073
77neuron fate specification (GO:0048665)2.67752762
78dopaminergic neuron differentiation (GO:0071542)2.66434682
79short-chain fatty acid metabolic process (GO:0046459)2.66191909
80innate immune response in mucosa (GO:0002227)2.64000519
81regulation of cellular amino acid metabolic process (GO:0006521)2.63945544
82regulation of appetite (GO:0032098)2.63513206
83adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.61611220
84CENP-A containing nucleosome assembly (GO:0034080)2.60687267
85cullin deneddylation (GO:0010388)2.59110197
86mitochondrial respiratory chain complex I assembly (GO:0032981)2.58453656
87NADH dehydrogenase complex assembly (GO:0010257)2.58453656
88mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.58453656
89negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.55861716
90negative regulation of ligase activity (GO:0051352)2.55861716
91regulation of activin receptor signaling pathway (GO:0032925)2.55731301
92positive regulation of meiosis (GO:0045836)2.55137011
93primitive streak formation (GO:0090009)2.54953839
94indolalkylamine metabolic process (GO:0006586)2.53681722
95recombinational repair (GO:0000725)2.53211667
96double-strand break repair via homologous recombination (GO:0000724)2.52035621
97pyrimidine nucleoside metabolic process (GO:0006213)2.50722953
98detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.48541593
99DNA ligation (GO:0006266)2.46629700
100pyrimidine ribonucleoside catabolic process (GO:0046133)10.4808576

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.07878800
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.69983685
3VDR_22108803_ChIP-Seq_LS180_Human3.41328882
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.35042077
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.14894980
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.03243784
7IGF1R_20145208_ChIP-Seq_DFB_Human2.91941522
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.82473035
9ZNF274_21170338_ChIP-Seq_K562_Hela2.81907952
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81624844
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.77771816
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.74452301
13EZH2_22144423_ChIP-Seq_EOC_Human2.52484735
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.36901157
15POU5F1_16153702_ChIP-ChIP_HESCs_Human2.32099760
16VDR_23849224_ChIP-Seq_CD4+_Human2.13900152
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.07556413
18MYC_18940864_ChIP-ChIP_HL60_Human2.07115521
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.03103267
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94895205
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.94577921
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.94093033
23IRF1_19129219_ChIP-ChIP_H3396_Human1.93729376
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91149525
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90694126
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85458809
27HTT_18923047_ChIP-ChIP_STHdh_Human1.84113723
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80126469
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.79232092
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69753350
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66139465
32MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.63372120
33SOX2_16153702_ChIP-ChIP_HESCs_Human1.62698793
34ELK1_19687146_ChIP-ChIP_HELA_Human1.62567535
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62482001
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.58417034
37GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.56766469
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54489050
39GBX2_23144817_ChIP-Seq_PC3_Human1.47726005
40FOXP3_21729870_ChIP-Seq_TREG_Human1.41453279
41EWS_26573619_Chip-Seq_HEK293_Human1.40311223
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.39164214
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38578387
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38164746
45TP53_22573176_ChIP-Seq_HFKS_Human1.36492823
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33948700
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33653929
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32833088
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31406892
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.30840106
51KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29980571
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28374946
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.27983067
54FUS_26573619_Chip-Seq_HEK293_Human1.25595016
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25511827
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22226308
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20301962
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.20279073
59JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19982877
60TAF15_26573619_Chip-Seq_HEK293_Human1.19614222
61P300_19829295_ChIP-Seq_ESCs_Human1.17485456
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16838853
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16493129
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16306431
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16091778
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.14610650
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13030760
68TTF2_22483619_ChIP-Seq_HELA_Human1.10732069
69BCAT_22108803_ChIP-Seq_LS180_Human1.09388059
70SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08406240
71NCOR_22424771_ChIP-Seq_293T_Human1.07464492
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07196684
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07002204
74ERA_21632823_ChIP-Seq_H3396_Human1.06689151
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05741055
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.04855189
77CBP_20019798_ChIP-Seq_JUKART_Human1.04709342
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04709342
79ER_23166858_ChIP-Seq_MCF-7_Human1.02634253
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99962266
81FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99210360
82REST_21632747_ChIP-Seq_MESCs_Mouse0.98586375
83RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98401566
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98302536
85SMAD4_21799915_ChIP-Seq_A2780_Human0.98126032
86SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97220995
87REST_18959480_ChIP-ChIP_MESCs_Mouse0.96705663
88AR_21572438_ChIP-Seq_LNCaP_Human0.95385125
89RNF2_27304074_Chip-Seq_NSC_Mouse0.95187349
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94242583
91KAP1_22055183_ChIP-Seq_ESCs_Mouse0.93541860
92SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93425147
93FOXA1_25329375_ChIP-Seq_VCAP_Human0.92147288
94FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92147288
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91484387
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91199691
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90444354
98EZH2_27294783_Chip-Seq_ESCs_Mouse0.90301302
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.89954720
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89382622

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ5.41562434
2MP0002102_abnormal_ear_morphology5.38256391
3MP0004742_abnormal_vestibular_system3.54763205
4MP0002277_abnormal_respiratory_mucosa3.30603683
5MP0008872_abnormal_physiological_respon2.51277768
6MP0003011_delayed_dark_adaptation2.27455606
7MP0010094_abnormal_chromosome_stability2.12017560
8MP0005084_abnormal_gallbladder_morpholo2.10419941
9MP0003136_yellow_coat_color2.06967471
10MP0002653_abnormal_ependyma_morphology2.04762296
11MP0000631_abnormal_neuroendocrine_gland1.97801720
12MP0001986_abnormal_taste_sensitivity1.97582116
13MP0003950_abnormal_plasma_membrane1.97534096
14MP0008875_abnormal_xenobiotic_pharmacok1.95641533
15MP0005671_abnormal_response_to1.84960831
16MP0008007_abnormal_cellular_replicative1.83558593
17MP0008058_abnormal_DNA_repair1.82326417
18MP0001905_abnormal_dopamine_level1.77200587
19MP0001485_abnormal_pinna_reflex1.73681474
20MP0006292_abnormal_olfactory_placode1.69006650
21MP0005448_abnormal_energy_balance1.68940101
22MP0001529_abnormal_vocalization1.65570874
23MP0003119_abnormal_digestive_system1.64859318
24MP0002693_abnormal_pancreas_physiology1.64134074
25MP0006276_abnormal_autonomic_nervous1.61609518
26MP0004885_abnormal_endolymph1.58361061
27MP0004133_heterotaxia1.56264328
28MP0002837_dystrophic_cardiac_calcinosis1.51938384
29MP0002638_abnormal_pupillary_reflex1.49363406
30MP0005253_abnormal_eye_physiology1.45171529
31MP0003959_abnormal_lean_body1.44536717
32MP0003693_abnormal_embryo_hatching1.43633325
33MP0002736_abnormal_nociception_after1.43292123
34MP0000778_abnormal_nervous_system1.37384069
35MP0001348_abnormal_lacrimal_gland1.35078550
36MP0001177_atelectasis1.33909095
37MP0009745_abnormal_behavioral_response1.33720945
38MP0009840_abnormal_foam_cell1.33687274
39MP0002735_abnormal_chemical_nociception1.33330056
40MP0006072_abnormal_retinal_apoptosis1.26340405
41MP0002272_abnormal_nervous_system1.25788741
42MP0002282_abnormal_trachea_morphology1.25146411
43MP0005551_abnormal_eye_electrophysiolog1.24194779
44MP0001968_abnormal_touch/_nociception1.18603668
45MP0002557_abnormal_social/conspecific_i1.15941666
46MP0003866_abnormal_defecation1.15788434
47MP0008789_abnormal_olfactory_epithelium1.14499803
48MP0005645_abnormal_hypothalamus_physiol1.13946761
49MP0002234_abnormal_pharynx_morphology1.12392523
50MP0002064_seizures1.12138546
51MP0002210_abnormal_sex_determination1.09921385
52MP0001944_abnormal_pancreas_morphology1.09786876
53MP0001835_abnormal_antigen_presentation1.09029083
54MP0001873_stomach_inflammation1.08154651
55MP0004142_abnormal_muscle_tone1.07785689
56MP0002928_abnormal_bile_duct0.98802708
57MP0003890_abnormal_embryonic-extraembry0.98616329
58MP0001929_abnormal_gametogenesis0.97775070
59MP0009333_abnormal_splenocyte_physiolog0.96056219
60MP0002751_abnormal_autonomic_nervous0.95598385
61MP0008775_abnormal_heart_ventricle0.95053862
62MP0001502_abnormal_circadian_rhythm0.94540221
63MP0001919_abnormal_reproductive_system0.93093341
64MP0000026_abnormal_inner_ear0.90998801
65MP0005085_abnormal_gallbladder_physiolo0.89325692
66MP0003635_abnormal_synaptic_transmissio0.87791435
67MP0004957_abnormal_blastocyst_morpholog0.85776244
68MP0002160_abnormal_reproductive_system0.85379982
69MP0003646_muscle_fatigue0.83761307
70MP0002734_abnormal_mechanical_nocicepti0.81125727
71MP0010329_abnormal_lipoprotein_level0.80929686
72MP0000049_abnormal_middle_ear0.80890520
73MP0003698_abnormal_male_reproductive0.79055746
74MP0001486_abnormal_startle_reflex0.77909136
75MP0005394_taste/olfaction_phenotype0.77257508
76MP0005499_abnormal_olfactory_system0.77257508
77MP0005220_abnormal_exocrine_pancreas0.76422349
78MP0003699_abnormal_female_reproductive0.76289019
79MP0005195_abnormal_posterior_eye0.74974902
80MP0001119_abnormal_female_reproductive0.74785175
81MP0008877_abnormal_DNA_methylation0.74559759
82MP0003786_premature_aging0.73750076
83MP0002932_abnormal_joint_morphology0.71992109
84MP0009785_altered_susceptibility_to0.70728091
85MP0002067_abnormal_sensory_capabilities0.70589000
86MP0002752_abnormal_somatic_nervous0.68982624
87MP0000383_abnormal_hair_follicle0.68498856
88MP0001963_abnormal_hearing_physiology0.67471299
89MP0000653_abnormal_sex_gland0.67111161
90MP0002909_abnormal_adrenal_gland0.66513475
91MP0000427_abnormal_hair_cycle0.66201450
92MP0001984_abnormal_olfaction0.66034866
93MP0005389_reproductive_system_phenotype0.65131209
94MP0002882_abnormal_neuron_morphology0.64829509
95MP0003943_abnormal_hepatobiliary_system0.64803684
96MP0005636_abnormal_mineral_homeostasis0.63729412
97MP0005391_vision/eye_phenotype0.63062538
98MP0001727_abnormal_embryo_implantation0.61991624
99MP0002161_abnormal_fertility/fecundity0.61661918
100MP0002572_abnormal_emotion/affect_behav0.61597023

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)6.41166083
2Biliary tract neoplasm (HP:0100574)6.20810614
3Retinal dysplasia (HP:0007973)6.11264476
4Neoplasm of the rectum (HP:0100743)4.53621013
5Neoplasm of the small intestine (HP:0100833)4.35667092
6Anterior segment dysgenesis (HP:0007700)4.34966640
7Acute necrotizing encephalopathy (HP:0006965)3.98163209
8Abnormal mitochondria in muscle tissue (HP:0008316)3.60997948
9Abnormal biliary tract morphology (HP:0012440)3.42305583
10Progressive macrocephaly (HP:0004481)3.34406391
11Neoplasm of the colon (HP:0100273)3.30317618
12Mitochondrial inheritance (HP:0001427)3.29166707
13Lissencephaly (HP:0001339)3.17140116
14Optic nerve hypoplasia (HP:0000609)3.11548152
15Generalized aminoaciduria (HP:0002909)3.10901917
16Acute encephalopathy (HP:0006846)3.05281496
17Birth length less than 3rd percentile (HP:0003561)3.03334536
18Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.90817594
19Increased CSF lactate (HP:0002490)2.86207811
20Progressive inability to walk (HP:0002505)2.82353674
21Cerebellar dysplasia (HP:0007033)2.77317692
22Pendular nystagmus (HP:0012043)2.75600834
23Increased hepatocellular lipid droplets (HP:0006565)2.74926896
24Neonatal respiratory distress (HP:0002643)2.69707930
25Retrobulbar optic neuritis (HP:0100654)2.55284973
26Optic neuritis (HP:0100653)2.55284973
27Partial agenesis of the corpus callosum (HP:0001338)2.52021096
28Increased serum lactate (HP:0002151)2.50024818
29Hepatic necrosis (HP:0002605)2.47157612
30Hepatocellular necrosis (HP:0001404)2.44013885
31Ketoacidosis (HP:0001993)2.43664883
32Ketosis (HP:0001946)2.42941581
33Cortical dysplasia (HP:0002539)2.41796716
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.41288362
35Decreased activity of mitochondrial respiratory chain (HP:0008972)2.41288362
36Lipid accumulation in hepatocytes (HP:0006561)2.38416772
37Ovarian neoplasm (HP:0100615)2.35703672
38Septo-optic dysplasia (HP:0100842)2.35442346
39Cerebral edema (HP:0002181)2.34546499
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.33808600
41Abolished electroretinogram (ERG) (HP:0000550)2.32392159
42Delayed CNS myelination (HP:0002188)2.28695977
43Tetraparesis (HP:0002273)2.25293302
44Uterine neoplasm (HP:0010784)2.25252467
45Abnormality of the pons (HP:0007361)2.21942729
46Intestinal atresia (HP:0011100)2.18690473
47Congenital stationary night blindness (HP:0007642)2.17213767
48Hypoplasia of the pons (HP:0012110)2.13919924
49Tetany (HP:0001281)2.11055037
50Degeneration of the lateral corticospinal tracts (HP:0002314)2.08682356
51Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.08682356
52Lactic acidosis (HP:0003128)2.03261859
53Male pseudohermaphroditism (HP:0000037)2.02008273
54Patellar aplasia (HP:0006443)2.01305357
55Neoplasm of the pancreas (HP:0002894)1.98859295
56Ascites (HP:0001541)1.98605760
57Pancreatic fibrosis (HP:0100732)1.98505695
58Type I diabetes mellitus (HP:0100651)1.97960327
59Aplasia/Hypoplasia of the patella (HP:0006498)1.96112062
60Pancytopenia (HP:0001876)1.95592179
61Inability to walk (HP:0002540)1.95343182
62Abnormality of the pancreatic islet cells (HP:0006476)1.91950058
63Abnormality of endocrine pancreas physiology (HP:0012093)1.91950058
64Exertional dyspnea (HP:0002875)1.91474558
65Orchitis (HP:0100796)1.91348175
66Aplastic anemia (HP:0001915)1.91134475
67Keratoconjunctivitis sicca (HP:0001097)1.89530998
68Portal hypertension (HP:0001409)1.88837055
69Keratoconjunctivitis (HP:0001096)1.88382018
70Hypoplastic pelvis (HP:0008839)1.87980456
71Intestinal polyposis (HP:0200008)1.87344266
72Aplasia/hypoplasia of the uterus (HP:0008684)1.85912704
73Pancreatic cysts (HP:0001737)1.83714538
74True hermaphroditism (HP:0010459)1.83030742
75Molar tooth sign on MRI (HP:0002419)1.82920732
76Abnormality of midbrain morphology (HP:0002418)1.82920732
77Methylmalonic acidemia (HP:0002912)1.82389116
78Leiomyosarcoma (HP:0100243)1.81311830
79Uterine leiomyosarcoma (HP:0002891)1.81311830
80Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.81159324
81Late onset (HP:0003584)1.80661414
82Abnormal number of incisors (HP:0011064)1.80644797
83Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.80407881
84Optic disc pallor (HP:0000543)1.79727137
85Reduced antithrombin III activity (HP:0001976)1.78956849
86Leukodystrophy (HP:0002415)1.78767047
87Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.78285814
88Renal Fanconi syndrome (HP:0001994)1.77126565
89Morphological abnormality of the middle ear (HP:0008609)1.76336786
90Impaired vibration sensation in the lower limbs (HP:0002166)1.76215343
91Aplasia/Hypoplasia of the brainstem (HP:0007362)1.75877089
92Hypoplasia of the brainstem (HP:0002365)1.75877089
93Gastrointestinal carcinoma (HP:0002672)1.75466359
94Malignant gastrointestinal tract tumors (HP:0006749)1.75466359
95Abnormal eating behavior (HP:0100738)1.75233428
96Abnormality of the corticospinal tract (HP:0002492)1.75150859
97Type I transferrin isoform profile (HP:0003642)1.74940360
98Abnormality of the hepatic vasculature (HP:0006707)1.74805251
99Congenital, generalized hypertrichosis (HP:0004540)1.73335886
100Exercise intolerance (HP:0003546)1.73165127

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK165.20887270
2MAP2K63.85187928
3INSRR3.41737574
4VRK13.28279223
5BRSK22.86017051
6PNCK2.68726572
7PASK2.51526291
8VRK22.49439490
9BUB12.19295993
10MAPK152.16159700
11ZAK2.03839006
12TESK21.95703520
13KDR1.94566210
14CDC71.80595877
15CAMKK21.80278376
16MAPK131.80144129
17WNK31.67865731
18NUAK11.60032240
19ADRBK21.56579751
20WEE11.53541891
21PBK1.45180595
22RPS6KA51.37381357
23NLK1.33915994
24IRAK11.33091241
25TYRO31.24614724
26LATS11.22861325
27TNIK1.21830909
28CDK151.17388154
29MAP2K71.17329298
30CDK11A1.16382983
31MAPKAPK31.16024614
32NTRK21.15060778
33DAPK21.14727035
34CCNB11.12100521
35CAMKK11.11862730
36CDK181.11436766
37TAOK31.11347703
38TSSK61.10801718
39MAP3K41.08496903
40TXK1.07781466
41TLK11.04450451
42DYRK21.03717800
43STK391.02597109
44CDK140.99162680
45NME10.96091555
46MKNK20.95144797
47SRPK10.92846536
48AURKA0.92657247
49MINK10.90927107
50CSF1R0.90883953
51MAP4K20.86695302
52OXSR10.86195110
53PRKCH0.82789328
54BMPR1B0.80975390
55GRK10.79483233
56BRSK10.78809295
57WNK40.72999723
58UHMK10.72894001
59PTK2B0.69868327
60PRKCG0.68351568
61TTK0.67805271
62RPS6KA40.67508834
63MARK10.63521975
64AURKB0.61032387
65PIM20.58555926
66PLK30.57896869
67BCKDK0.57370762
68CHEK20.55587888
69CASK0.55362188
70CLK10.54507591
71DAPK10.51799734
72TGFBR20.50710354
73CHUK0.49331399
74ITK0.48660608
75PLK10.43683082
76CSNK2A10.43392279
77FRK0.43216336
78CDK30.41454771
79ATR0.41242125
80PAK10.40938319
81ACVR1B0.39051407
82EPHA30.36754148
83MKNK10.36047172
84MAP4K10.35524447
85DAPK30.34116276
86LIMK10.33147230
87GRK70.32669052
88PRKCE0.32615952
89MAPK110.32477486
90PRKACA0.32115661
91AKT30.31148790
92DYRK30.30044740
93MYLK0.29869120
94CSNK2A20.28033823
95GRK50.27881299
96EPHB20.26954021
97MAPKAPK50.26026728
98PRKCQ0.24764792
99GSK3A0.24441437
100CAMK2A0.22403777

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.96251657
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.88780407
3Proteasome_Homo sapiens_hsa030503.65726459
4Oxidative phosphorylation_Homo sapiens_hsa001903.37860187
5Parkinsons disease_Homo sapiens_hsa050123.25035201
6Homologous recombination_Homo sapiens_hsa034402.88968930
7One carbon pool by folate_Homo sapiens_hsa006702.62072765
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49695817
9RNA polymerase_Homo sapiens_hsa030202.28858658
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.06344692
11Huntingtons disease_Homo sapiens_hsa050161.98693432
12Pyrimidine metabolism_Homo sapiens_hsa002401.89500097
13Systemic lupus erythematosus_Homo sapiens_hsa053221.88417811
14Cardiac muscle contraction_Homo sapiens_hsa042601.84056243
15Ribosome_Homo sapiens_hsa030101.83725016
16Alzheimers disease_Homo sapiens_hsa050101.82934970
17DNA replication_Homo sapiens_hsa030301.78802423
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76836989
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.61876585
20Asthma_Homo sapiens_hsa053101.61810101
21Protein export_Homo sapiens_hsa030601.61518199
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61231348
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60316596
24Spliceosome_Homo sapiens_hsa030401.50346379
25Fanconi anemia pathway_Homo sapiens_hsa034601.45565729
26Butanoate metabolism_Homo sapiens_hsa006501.45059601
27Allograft rejection_Homo sapiens_hsa053301.40198968
28Steroid biosynthesis_Homo sapiens_hsa001001.35693362
29Autoimmune thyroid disease_Homo sapiens_hsa053201.33777199
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.25694551
31Fatty acid biosynthesis_Homo sapiens_hsa000611.25560995
32Tryptophan metabolism_Homo sapiens_hsa003801.25341283
33Alcoholism_Homo sapiens_hsa050341.20679053
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20207965
35Phototransduction_Homo sapiens_hsa047441.19719789
36Non-homologous end-joining_Homo sapiens_hsa034501.16668924
37Purine metabolism_Homo sapiens_hsa002301.16079859
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.14254009
39Caffeine metabolism_Homo sapiens_hsa002321.10188937
40Linoleic acid metabolism_Homo sapiens_hsa005911.06947512
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06289819
42Fatty acid degradation_Homo sapiens_hsa000711.05600148
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02394272
44Primary immunodeficiency_Homo sapiens_hsa053400.97227582
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.96072079
46Base excision repair_Homo sapiens_hsa034100.92547332
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92485837
48Nucleotide excision repair_Homo sapiens_hsa034200.90872739
49Fatty acid metabolism_Homo sapiens_hsa012120.88037612
50Nicotine addiction_Homo sapiens_hsa050330.85605598
51Propanoate metabolism_Homo sapiens_hsa006400.83267407
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79200570
53Basal transcription factors_Homo sapiens_hsa030220.78841666
54Retinol metabolism_Homo sapiens_hsa008300.77038061
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69548240
56Circadian rhythm_Homo sapiens_hsa047100.64708333
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64422686
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61352827
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60381148
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57780405
61RNA transport_Homo sapiens_hsa030130.57669344
62Cocaine addiction_Homo sapiens_hsa050300.57245753
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53390628
64Metabolic pathways_Homo sapiens_hsa011000.53079734
65Morphine addiction_Homo sapiens_hsa050320.52662552
66Type I diabetes mellitus_Homo sapiens_hsa049400.51007880
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.50801949
68Selenocompound metabolism_Homo sapiens_hsa004500.49486265
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47244602
70Regulation of autophagy_Homo sapiens_hsa041400.46785372
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42121028
72Taste transduction_Homo sapiens_hsa047420.40768217
73Pyruvate metabolism_Homo sapiens_hsa006200.40177478
74p53 signaling pathway_Homo sapiens_hsa041150.38490854
75RNA degradation_Homo sapiens_hsa030180.38068068
76Epstein-Barr virus infection_Homo sapiens_hsa051690.36793731
77Bile secretion_Homo sapiens_hsa049760.36352836
78Hematopoietic cell lineage_Homo sapiens_hsa046400.35112200
79Graft-versus-host disease_Homo sapiens_hsa053320.34974539
80Chemical carcinogenesis_Homo sapiens_hsa052040.33226365
81Mineral absorption_Homo sapiens_hsa049780.33216361
82Fat digestion and absorption_Homo sapiens_hsa049750.31450240
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30493408
84Olfactory transduction_Homo sapiens_hsa047400.29845530
85Fatty acid elongation_Homo sapiens_hsa000620.29022646
86Cell cycle_Homo sapiens_hsa041100.27671448
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26930347
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24940658
89Oocyte meiosis_Homo sapiens_hsa041140.23445761
90Amphetamine addiction_Homo sapiens_hsa050310.21710679
91Starch and sucrose metabolism_Homo sapiens_hsa005000.21668814
92Antigen processing and presentation_Homo sapiens_hsa046120.20837175
93Insulin secretion_Homo sapiens_hsa049110.19746105
94mRNA surveillance pathway_Homo sapiens_hsa030150.19270632
95Peroxisome_Homo sapiens_hsa041460.18600594
96T cell receptor signaling pathway_Homo sapiens_hsa046600.18421037
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18038385
98PPAR signaling pathway_Homo sapiens_hsa033200.16059890
99Serotonergic synapse_Homo sapiens_hsa047260.15971085
100Ether lipid metabolism_Homo sapiens_hsa005650.15864974

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