RAD21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.39019147
2nuclear pore organization (GO:0006999)5.06528310
3nuclear pore complex assembly (GO:0051292)4.97406695
4mitotic chromosome condensation (GO:0007076)4.96376029
5mitotic sister chromatid cohesion (GO:0007064)4.94298679
6regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.93771282
7DNA unwinding involved in DNA replication (GO:0006268)4.89556124
8sister chromatid segregation (GO:0000819)4.78137561
9protein localization to chromosome, centromeric region (GO:0071459)4.64636843
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.64539481
11mitotic sister chromatid segregation (GO:0000070)4.47948773
12regulation of RNA export from nucleus (GO:0046831)4.44635990
13DNA ligation (GO:0006266)4.19980209
14heterochromatin organization (GO:0070828)4.12793400
15regulation of sister chromatid cohesion (GO:0007063)4.09994260
16positive regulation of chromosome segregation (GO:0051984)4.09105582
17regulation of centriole replication (GO:0046599)4.07276526
18regulation of spindle organization (GO:0090224)4.04755488
19mitotic nuclear envelope disassembly (GO:0007077)4.00285985
20positive regulation of mitotic sister chromatid separation (GO:1901970)3.99043990
21positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.99043990
22positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.99043990
23pre-miRNA processing (GO:0031054)3.97440281
24attachment of spindle microtubules to kinetochore (GO:0008608)3.92209593
25mitotic metaphase plate congression (GO:0007080)3.90890482
26establishment of integrated proviral latency (GO:0075713)3.89329026
27CENP-A containing nucleosome assembly (GO:0034080)3.84194471
28membrane disassembly (GO:0030397)3.81115391
29nuclear envelope disassembly (GO:0051081)3.81115391
30DNA strand elongation involved in DNA replication (GO:0006271)3.79815468
31negative regulation of histone methylation (GO:0031061)3.79490063
32kinetochore organization (GO:0051383)3.78066356
33pore complex assembly (GO:0046931)3.75306971
34DNA strand elongation (GO:0022616)3.70726857
35chromatin remodeling at centromere (GO:0031055)3.68410755
36regulation of mitotic spindle organization (GO:0060236)3.67557322
37regulation of nucleobase-containing compound transport (GO:0032239)3.65559797
38glucocorticoid receptor signaling pathway (GO:0042921)3.63863152
39metaphase plate congression (GO:0051310)3.61490858
40sister chromatid cohesion (GO:0007062)3.61023740
41regulation of histone H3-K9 methylation (GO:0051570)3.60297212
42DNA duplex unwinding (GO:0032508)3.53748438
43chromatin assembly (GO:0031497)3.53294376
44DNA geometric change (GO:0032392)3.52058976
45* protein localization to chromosome (GO:0034502)3.50584884
46V(D)J recombination (GO:0033151)3.47495102
47microtubule depolymerization (GO:0007019)3.46534443
48histone-serine phosphorylation (GO:0035404)3.46381767
49regulation of chromosome segregation (GO:0051983)3.46377170
50chromosome condensation (GO:0030261)3.42957570
51dosage compensation (GO:0007549)3.42573264
52double-strand break repair via nonhomologous end joining (GO:0006303)3.41793843
53non-recombinational repair (GO:0000726)3.41793843
54mRNA stabilization (GO:0048255)3.31130216
55RNA stabilization (GO:0043489)3.31130216
56mitotic spindle organization (GO:0007052)3.30372525
57DNA topological change (GO:0006265)3.27930279
58histone exchange (GO:0043486)3.27106266
59establishment of chromosome localization (GO:0051303)3.25925441
60telomere maintenance via semi-conservative replication (GO:0032201)3.25169851
61mitotic recombination (GO:0006312)3.23274619
62regulation of centrosome duplication (GO:0010824)3.22838335
63nuclear envelope organization (GO:0006998)3.21472083
64protein complex localization (GO:0031503)3.20776260
65NLS-bearing protein import into nucleus (GO:0006607)3.18390898
66spindle checkpoint (GO:0031577)3.16475708
67cellular protein complex localization (GO:0034629)3.16323770
68histone H2A monoubiquitination (GO:0035518)3.16162589
69regulation of DNA endoreduplication (GO:0032875)3.12434186
70negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.11561539
71chromatin assembly or disassembly (GO:0006333)3.10948096
72alternative mRNA splicing, via spliceosome (GO:0000380)3.10881401
73microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.10784429
74monoubiquitinated protein deubiquitination (GO:0035520)3.10570179
75corticosteroid receptor signaling pathway (GO:0031958)3.08789515
76positive regulation of histone H3-K4 methylation (GO:0051571)3.08411062
77regulation of translational termination (GO:0006449)3.07113562
78spindle assembly involved in mitosis (GO:0090307)3.05242493
79regulation of mitotic metaphase/anaphase transition (GO:0030071)3.04567720
80DNA conformation change (GO:0071103)3.03828602
81peptidyl-lysine dimethylation (GO:0018027)3.03355869
82meiotic chromosome segregation (GO:0045132)3.03054574
83spindle assembly checkpoint (GO:0071173)3.02893105
84mitotic cytokinesis (GO:0000281)3.01806987
85spindle organization (GO:0007051)3.00539754
86* chromosome segregation (GO:0007059)2.98787240
87cytoplasmic mRNA processing body assembly (GO:0033962)2.98275437
88DNA replication-dependent nucleosome assembly (GO:0006335)2.96705607
89DNA replication-dependent nucleosome organization (GO:0034723)2.96705607
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.96636888
91gene silencing by RNA (GO:0031047)2.95307431
92negative regulation of chromosome segregation (GO:0051985)2.94683868
93hippo signaling (GO:0035329)2.94260353
94mitotic spindle checkpoint (GO:0071174)2.94151544
95telomere maintenance via recombination (GO:0000722)2.93681289
96DNA packaging (GO:0006323)2.93155191
97histone phosphorylation (GO:0016572)2.92682072
98translesion synthesis (GO:0019985)2.91219693
99DNA replication checkpoint (GO:0000076)2.91126141
100mitotic spindle assembly checkpoint (GO:0007094)2.90601259
101establishment of mitotic spindle localization (GO:0040001)2.89678659
102regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.89513128
103negative regulation of RNA splicing (GO:0033119)2.88695909
104mitotic G2/M transition checkpoint (GO:0044818)2.87851492
105regulation of mitotic sister chromatid separation (GO:0010965)2.87340276
106regulation of mitotic sister chromatid segregation (GO:0033047)2.87340276
107regulation of sister chromatid segregation (GO:0033045)2.87340276
108kinetochore assembly (GO:0051382)2.87187867
109negative regulation of mitotic sister chromatid separation (GO:2000816)2.84429198
110negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84429198
111negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84429198
112negative regulation of sister chromatid segregation (GO:0033046)2.84429198
113regulation of translational fidelity (GO:0006450)2.83571880
114protein localization to microtubule (GO:0035372)2.83051380
115DNA synthesis involved in DNA repair (GO:0000731)2.81432118
116regulation of histone H3-K27 methylation (GO:0061085)2.80313301
117nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.79903875
118spindle assembly (GO:0051225)2.79296212
119DNA replication initiation (GO:0006270)2.77648986
120negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.74758078
121DNA replication-independent nucleosome organization (GO:0034724)2.74339934
122DNA replication-independent nucleosome assembly (GO:0006336)2.74339934
123negative regulation of DNA repair (GO:0045738)2.74078144
124negative regulation of mRNA metabolic process (GO:1903312)2.73733039
125gene silencing (GO:0016458)2.73626110
126regulation of centrosome cycle (GO:0046605)2.73475957
127regulation of helicase activity (GO:0051095)2.73350603
128negative regulation of mRNA processing (GO:0050686)2.72174614
129ATP-dependent chromatin remodeling (GO:0043044)2.71585790
130regulation of mRNA stability (GO:0043488)2.69341223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.79096084
2FOXM1_23109430_ChIP-Seq_U2OS_Human7.28572947
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.13558912
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.99424577
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.56212700
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.99860164
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.81508334
8MYC_22102868_ChIP-Seq_BL_Human2.76477111
9* AR_21909140_ChIP-Seq_LNCAP_Human2.76420712
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.44283063
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.35671139
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.35050217
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.13060078
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.05114362
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01290150
16TP63_19390658_ChIP-ChIP_HaCaT_Human1.93870962
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83033813
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82402207
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77464412
20NELFA_20434984_ChIP-Seq_ESCs_Mouse1.76221530
21ZNF263_19887448_ChIP-Seq_K562_Human1.72781225
22RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66741039
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66559893
24MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65823339
25CIITA_25753668_ChIP-Seq_RAJI_Human1.62857826
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.57699931
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54500790
28CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53319401
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52039410
30SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.51416381
31HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.51181137
32TCF7_22412390_ChIP-Seq_EML_Mouse1.48955473
33VDR_21846776_ChIP-Seq_THP-1_Human1.47194097
34* KDM5A_27292631_Chip-Seq_BREAST_Human1.46101502
35XRN2_22483619_ChIP-Seq_HELA_Human1.43087477
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42894494
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38711297
38PKCTHETA_26484144_Chip-Seq_BREAST_Human1.37205251
39NANOG_21062744_ChIP-ChIP_HESCs_Human1.37182388
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37003257
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36172445
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35547182
43KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35264904
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34515144
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33754550
46CHD1_26751641_Chip-Seq_LNCaP_Human1.33259678
47* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32116638
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32033508
49DCP1A_22483619_ChIP-Seq_HELA_Human1.29217482
50* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28631868
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.27860725
52KDM2B_26808549_Chip-Seq_DND41_Human1.27203605
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27121309
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26519385
55SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26193130
56* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25592537
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22955265
58CLOCK_20551151_ChIP-Seq_293T_Human1.21366295
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19586081
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.18043419
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.18043419
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.18043419
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16083389
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14360478
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14190311
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13030361
67FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.12654856
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12404573
69* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11079964
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10419386
71* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09927316
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09728345
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06803597
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06745463
75* ATF3_27146783_Chip-Seq_COLON_Human1.06702985
76* UTX_26944678_Chip-Seq_JUKART_Human1.05320353
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04515378
78MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03829749
79CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02879144
80* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01690482
81MAF_26560356_Chip-Seq_TH1_Human1.01171241
82* NCOR1_26117541_ChIP-Seq_K562_Human1.01002639
83ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00734233
84TFEB_21752829_ChIP-Seq_HELA_Human1.00668638
85SOX17_20123909_ChIP-Seq_XEN_Mouse1.00353245
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98848823
87* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98698157
88TTF2_22483619_ChIP-Seq_HELA_Human0.98654185
89ELK3_25401928_ChIP-Seq_HUVEC_Human0.98483151
90PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97286756
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96591576
92SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96318311
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95979913
94NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95448033
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95389847
96* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93916378
97STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93063924
98FOXP3_21729870_ChIP-Seq_TREG_Human0.92151021
99ELK1_19687146_ChIP-ChIP_HELA_Human0.91365706
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89986842
101ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89078932
102VDR_23849224_ChIP-Seq_CD4+_Human0.88833153
103NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87828612
104KDM2B_26808549_Chip-Seq_JURKAT_Human0.87633598
105E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87420826
106THAP11_20581084_ChIP-Seq_MESCs_Mouse0.87243706
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87066626
108* GABP_19822575_ChIP-Seq_HepG2_Human0.86542322
109BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86407329
110TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86114399
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.86043701
112SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85765327
113MYB_26560356_Chip-Seq_TH1_Human0.85025493
114* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84922831
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84912411
116* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84187956
117NANOG_16153702_ChIP-ChIP_HESCs_Human0.81876239
118EST1_17652178_ChIP-ChIP_JURKAT_Human0.81581409
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79670803
120TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79569275
121* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.79164479
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77782430
123* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.77623114
124ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.76878025
125SOX2_16153702_ChIP-ChIP_HESCs_Human0.75917389
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74607630
127FUS_26573619_Chip-Seq_HEK293_Human0.73442226
128POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.73384158
129WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.72967623
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.71610411
131POU5F1_16153702_ChIP-ChIP_HESCs_Human0.70360977
132ERG_20887958_ChIP-Seq_HPC-7_Mouse0.69652705
133SOX9_26525672_Chip-Seq_HEART_Mouse0.69162545
134EWS_26573619_Chip-Seq_HEK293_Human0.69068524
135TCF3_18692474_ChIP-Seq_MESCs_Mouse0.67162181
136NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.66891869
137ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.65107331

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.33161102
2MP0010094_abnormal_chromosome_stability3.10661162
3MP0004957_abnormal_blastocyst_morpholog3.10121088
4MP0003693_abnormal_embryo_hatching3.01178028
5MP0003077_abnormal_cell_cycle2.94450892
6MP0010352_gastrointestinal_tract_polyps2.89301099
7MP0005076_abnormal_cell_differentiation2.89072230
8MP0003705_abnormal_hypodermis_morpholog2.83181715
9MP0003123_paternal_imprinting2.80179252
10MP0008057_abnormal_DNA_replication2.74297650
11MP0000537_abnormal_urethra_morphology2.36672433
12MP0001730_embryonic_growth_arrest2.33148322
13MP0002877_abnormal_melanocyte_morpholog2.31665433
14MP0010307_abnormal_tumor_latency2.31075895
15MP0003300_gastrointestinal_ulcer2.23661122
16MP0000350_abnormal_cell_proliferation2.12494935
17MP0003121_genomic_imprinting1.96198658
18MP0008877_abnormal_DNA_methylation1.92461376
19MP0005380_embryogenesis_phenotype1.90460744
20MP0001672_abnormal_embryogenesis/_devel1.90460744
21MP0004197_abnormal_fetal_growth/weight/1.89868045
22MP0002084_abnormal_developmental_patter1.87674413
23MP0001697_abnormal_embryo_size1.87602025
24MP0002086_abnormal_extraembryonic_tissu1.85255327
25MP0003984_embryonic_growth_retardation1.83442468
26MP0010234_abnormal_vibrissa_follicle1.80789126
27MP0008007_abnormal_cellular_replicative1.80731062
28MP0002088_abnormal_embryonic_growth/wei1.80613369
29MP0002085_abnormal_embryonic_tissue1.77705950
30MP0003567_abnormal_fetal_cardiomyocyte1.76167774
31MP0002396_abnormal_hematopoietic_system1.69689503
32MP0004808_abnormal_hematopoietic_stem1.67873939
33MP0009697_abnormal_copulation1.65742350
34MP0001849_ear_inflammation1.63947880
35MP0009278_abnormal_bone_marrow1.62738673
36MP0002009_preneoplasia1.58757314
37MP0003566_abnormal_cell_adhesion1.57763949
38MP0000566_synostosis1.55706596
39MP0004264_abnormal_extraembryonic_tissu1.53370977
40* MP0002080_prenatal_lethality1.53307013
41MP0000733_abnormal_muscle_development1.51876556
42MP0001346_abnormal_lacrimal_gland1.47979999
43MP0008932_abnormal_embryonic_tissue1.45075538
44MP0009053_abnormal_anal_canal1.43769639
45MP0000428_abnormal_craniofacial_morphol1.39663233
46MP0010030_abnormal_orbit_morphology1.36714729
47MP0004233_abnormal_muscle_weight1.36392735
48MP0005623_abnormal_meninges_morphology1.35616611
49MP0003937_abnormal_limbs/digits/tail_de1.29510355
50MP0009703_decreased_birth_body1.28720748
51MP0003943_abnormal_hepatobiliary_system1.28127552
52MP0004185_abnormal_adipocyte_glucose1.28049131
53MP0003890_abnormal_embryonic-extraembry1.27319612
54MP0005248_abnormal_Harderian_gland1.24987651
55MP0008058_abnormal_DNA_repair1.23990630
56MP0000569_abnormal_digit_pigmentation1.23799693
57MP0000490_abnormal_crypts_of1.20104167
58MP0006054_spinal_hemorrhage1.16945861
59MP0009672_abnormal_birth_weight1.16248372
60MP0001915_intracranial_hemorrhage1.13926277
61MP0003935_abnormal_craniofacial_develop1.13617460
62MP0003119_abnormal_digestive_system1.11047818
63MP0005187_abnormal_penis_morphology1.10115080
64MP0003122_maternal_imprinting1.09295801
65MP0003385_abnormal_body_wall1.06959639
66MP0002925_abnormal_cardiovascular_devel1.06482552
67MP0002019_abnormal_tumor_incidence1.06150531
68MP0001293_anophthalmia1.05015149
69MP0003941_abnormal_skin_development1.04329576
70MP0003115_abnormal_respiratory_system1.03992746
71MP0000313_abnormal_cell_death1.02267381
72MP0002233_abnormal_nose_morphology0.98909996
73MP0003787_abnormal_imprinting0.98373613
74MP0002092_abnormal_eye_morphology0.98154966
75MP0003283_abnormal_digestive_organ0.97487751
76MP0000432_abnormal_head_morphology0.97106590
77MP0005257_abnormal_intraocular_pressure0.97024964
78MP0000703_abnormal_thymus_morphology0.96868713
79MP0002796_impaired_skin_barrier0.94718837
80MP0001545_abnormal_hematopoietic_system0.94124349
81MP0005397_hematopoietic_system_phenotyp0.94124349
82MP0010678_abnormal_skin_adnexa0.93278350
83MP0003221_abnormal_cardiomyocyte_apopto0.91813223
84MP0002111_abnormal_tail_morphology0.91122536
85MP0002166_altered_tumor_susceptibility0.89742823
86MP0005409_darkened_coat_color0.88825199
87MP0010630_abnormal_cardiac_muscle0.88107568
88MP0000477_abnormal_intestine_morphology0.87328282
89MP0002697_abnormal_eye_size0.87257895
90MP0000377_abnormal_hair_follicle0.84418967
91MP0002006_tumorigenesis0.83670094
92MP0003315_abnormal_perineum_morphology0.83256596
93MP0001784_abnormal_fluid_regulation0.80862871
94MP0000266_abnormal_heart_morphology0.80446378
95* MP0001929_abnormal_gametogenesis0.79364351
96MP0005621_abnormal_cell_physiology0.78783291
97MP0002098_abnormal_vibrissa_morphology0.77712514
98MP0002081_perinatal_lethality0.76752679
99MP0003091_abnormal_cell_migration0.76481592
100MP0003786_premature_aging0.76316202
101MP0000762_abnormal_tongue_morphology0.76280947
102MP0000627_abnormal_mammary_gland0.75613144
103MP0001340_abnormal_eyelid_morphology0.73665110
104MP0001145_abnormal_male_reproductive0.72966277
105MP0005501_abnormal_skin_physiology0.72862032
106MP0003755_abnormal_palate_morphology0.72507188
107MP0003453_abnormal_keratinocyte_physiol0.72452718
108MP0005023_abnormal_wound_healing0.72128552
109MP0003942_abnormal_urinary_system0.71851576
110MP0002210_abnormal_sex_determination0.71601947
111MP0008961_abnormal_basal_metabolism0.70708622
112MP0000383_abnormal_hair_follicle0.70576572
113MP0003861_abnormal_nervous_system0.70529323
114MP0005384_cellular_phenotype0.70483033
115MP0001286_abnormal_eye_development0.69345791
116MP0002932_abnormal_joint_morphology0.69269012
117MP0001177_atelectasis0.69045759
118MP0006292_abnormal_olfactory_placode0.67621762
119MP0002114_abnormal_axial_skeleton0.67430543
120MP0000647_abnormal_sebaceous_gland0.67291507
121MP0000462_abnormal_digestive_system0.66699124
122MP0001188_hyperpigmentation0.66632664
123MP0003303_peritoneal_inflammation0.66118941
124MP0002928_abnormal_bile_duct0.65773248
125MP0002398_abnormal_bone_marrow0.64278300
126MP0008770_decreased_survivor_rate0.64269403

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.66514245
2Ependymoma (HP:0002888)3.36951469
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.34112825
4Short 4th metacarpal (HP:0010044)3.34112825
5Nephroblastoma (Wilms tumor) (HP:0002667)3.32541518
6Embryonal renal neoplasm (HP:0011794)3.18173819
7Astrocytoma (HP:0009592)2.95350851
8Abnormality of the astrocytes (HP:0100707)2.95350851
9* Increased nuchal translucency (HP:0010880)2.87952000
10Selective tooth agenesis (HP:0001592)2.87183496
11Macroorchidism (HP:0000053)2.83630626
12Insidious onset (HP:0003587)2.77598873
13Termporal pattern (HP:0011008)2.77598873
14Subacute progressive viral hepatitis (HP:0006572)2.72233819
15Abnormal lung lobation (HP:0002101)2.66449876
16Abnormality of the preputium (HP:0100587)2.66141000
17Hyperacusis (HP:0010780)2.62942067
18Abnormality of the 4th metacarpal (HP:0010012)2.58691221
19Heterotopia (HP:0002282)2.54452177
20Meckel diverticulum (HP:0002245)2.49065032
21Ankle contracture (HP:0006466)2.48663713
22* Deviation of the thumb (HP:0009603)2.46945092
23Glioma (HP:0009733)2.45820041
24Abnormality of the fingertips (HP:0001211)2.45509421
25Duodenal stenosis (HP:0100867)2.44618193
26Small intestinal stenosis (HP:0012848)2.44618193
27* Volvulus (HP:0002580)2.44057667
28* Proximal placement of thumb (HP:0009623)2.43581169
29Facial hemangioma (HP:0000329)2.43333767
30Myelodysplasia (HP:0002863)2.43206304
31High pitched voice (HP:0001620)2.43130917
32Medulloblastoma (HP:0002885)2.42316851
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.41116655
34Colon cancer (HP:0003003)2.36772793
35Renal duplication (HP:0000075)2.36421486
36Biliary tract neoplasm (HP:0100574)2.36280094
37Cystic hygroma (HP:0000476)2.31827803
38Shallow orbits (HP:0000586)2.30943035
39Leiomyosarcoma (HP:0100243)2.29774118
40Uterine leiomyosarcoma (HP:0002891)2.29774118
41Neoplasm of the oral cavity (HP:0100649)2.28282799
42Abnormality of the ileum (HP:0001549)2.27838629
43Malignant gastrointestinal tract tumors (HP:0006749)2.27784772
44Gastrointestinal carcinoma (HP:0002672)2.27784772
45Prominent nose (HP:0000448)2.27035219
46Embryonal neoplasm (HP:0002898)2.26152965
47Enlarged penis (HP:0000040)2.24207420
48Microglossia (HP:0000171)2.22163190
49Impulsivity (HP:0100710)2.21963294
50Rhabdomyosarcoma (HP:0002859)2.21146957
51Abnormality of the fetal cardiovascular system (HP:0010948)2.20975738
52Abnormal umbilical cord blood vessels (HP:0011403)2.20975738
53Single umbilical artery (HP:0001195)2.20975738
54Cerebral aneurysm (HP:0004944)2.20649007
55Basal cell carcinoma (HP:0002671)2.18127020
56Rectal prolapse (HP:0002035)2.15268212
57Acute myeloid leukemia (HP:0004808)2.12423665
58Pelvic girdle muscle weakness (HP:0003749)2.11504312
59Abnormality of the duodenum (HP:0002246)2.11237656
60Abnormality of the labia minora (HP:0012880)2.11010193
61Birth length less than 3rd percentile (HP:0003561)2.10423000
62Urethral obstruction (HP:0000796)2.09669327
63Bladder neoplasm (HP:0009725)2.09012715
64Bladder carcinoma (HP:0002862)2.09012715
65Long eyelashes (HP:0000527)2.08713278
66Broad palm (HP:0001169)2.07571347
67Cafe-au-lait spot (HP:0000957)2.04502109
68Neoplasm of striated muscle (HP:0009728)2.03837287
69Abnormality of the carotid arteries (HP:0005344)2.03523496
70High anterior hairline (HP:0009890)2.02652834
71Abnormal foot bone ossification (HP:0010675)1.99878805
72Absent radius (HP:0003974)1.99183534
73Abnormality of chromosome stability (HP:0003220)1.98869481
74Abnormal number of incisors (HP:0011064)1.98371208
75Broad thumb (HP:0011304)1.98177333
76Overriding aorta (HP:0002623)1.97032148
77Increased density of long bones (HP:0006392)1.96971512
78Abnormality of chromosome segregation (HP:0002916)1.95384298
79Ectopic kidney (HP:0000086)1.94339498
80Limited elbow extension (HP:0001377)1.93186872
81Renovascular hypertension (HP:0100817)1.92591088
82Trigonocephaly (HP:0000243)1.91883110
83Sandal gap (HP:0001852)1.89995037
84Patellar aplasia (HP:0006443)1.89614293
85Curly hair (HP:0002212)1.89312489
86Fibrous tissue neoplasm (HP:0012316)1.87941154
87Sloping forehead (HP:0000340)1.87781308
88Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.87551369
89* Atresia of the external auditory canal (HP:0000413)1.86017341
90Ovarian neoplasm (HP:0100615)1.85706895
91Ankyloglossia (HP:0010296)1.85699336
92Progressive external ophthalmoplegia (HP:0000590)1.85078556
93Elfin facies (HP:0004428)1.84319087
94Long clavicles (HP:0000890)1.83366522
95Aqueductal stenosis (HP:0002410)1.83293783
96Fibroma (HP:0010614)1.82958603
97Insomnia (HP:0100785)1.82877419
98Aplasia/Hypoplasia of the patella (HP:0006498)1.82652799
99Deep philtrum (HP:0002002)1.82278721
100Intestinal polyp (HP:0005266)1.82120699
101Abnormality of the calcaneus (HP:0008364)1.80892643
102Absent forearm bone (HP:0003953)1.80054460
103Aplasia involving forearm bones (HP:0009822)1.80054460
104Bowel diverticulosis (HP:0005222)1.80011500
105Intestinal polyposis (HP:0200008)1.79549796
106Thyroid carcinoma (HP:0002890)1.78290275
107Abnormality of the umbilical cord (HP:0010881)1.78054574
108Overlapping toe (HP:0001845)1.77933774
109Uterine neoplasm (HP:0010784)1.77577756
110Spinal cord lesions (HP:0100561)1.77568922
111Syringomyelia (HP:0003396)1.77568922
112Relative macrocephaly (HP:0004482)1.77269415
113Pseudobulbar signs (HP:0002200)1.76581525
114* Obsessive-compulsive behavior (HP:0000722)1.76037393
115Asymmetry of the thorax (HP:0001555)1.75458285
116Abnormality of the left ventricular outflow tract (HP:0011103)1.75308036
117Subaortic stenosis (HP:0001682)1.75308036
118Arteriovenous malformation (HP:0100026)1.75272444
119Cutaneous melanoma (HP:0012056)1.74900637
120Missing ribs (HP:0000921)1.74778346
121Metaphyseal cupping (HP:0003021)1.74713648
122Neoplasm of the small intestine (HP:0100833)1.73787059
123Abnormality of the musculature of the pelvis (HP:0001469)1.72543399
124Abnormality of the hip-girdle musculature (HP:0001445)1.72543399
125Skin tags (HP:0010609)1.72464988
12611 pairs of ribs (HP:0000878)1.72418860
127Ulnar bowing (HP:0003031)1.71999810
128Skull defect (HP:0001362)1.71755463
129Chromsome breakage (HP:0040012)1.71287460
130Vertebral arch anomaly (HP:0008438)1.70784154
131Abnormality of oral frenula (HP:0000190)1.69511418
132Broad phalanges of the hand (HP:0009768)1.69186549
133Degeneration of anterior horn cells (HP:0002398)1.68483256
134Abnormality of the anterior horn cell (HP:0006802)1.68483256
135Acute lymphatic leukemia (HP:0006721)1.68177771
136Hallux valgus (HP:0001822)1.68057576
137Aplasia/Hypoplasia of the sternum (HP:0006714)1.67943473
138Flared metaphyses (HP:0003015)1.67902665
139Short middle phalanx of finger (HP:0005819)1.66602977
140Neoplasm of the colon (HP:0100273)1.66418673
141Deviation of the hallux (HP:0010051)1.66129768
142Cortical dysplasia (HP:0002539)1.65926246
143Pointed chin (HP:0000307)1.65576116
144Sparse lateral eyebrow (HP:0005338)1.65550888
145* Choanal atresia (HP:0000453)1.65149013
146Short humerus (HP:0005792)1.64577446
147Large earlobe (HP:0009748)1.64382306
148* Truncal obesity (HP:0001956)1.64015079
149Short 1st metacarpal (HP:0010034)1.63966289
150Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.63966289
151Bicuspid aortic valve (HP:0001647)1.63872091
152Transitional cell carcinoma of the bladder (HP:0006740)1.63431665
153Papillary thyroid carcinoma (HP:0002895)1.63379968
154Anal stenosis (HP:0002025)1.63185148
155Neoplasm of the rectum (HP:0100743)1.63078851
156Neoplasm of the pancreas (HP:0002894)1.62962424
157Short middle phalanx of the 5th finger (HP:0004220)1.53614795
158Hypospadias (HP:0000047)1.53273581

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.00854811
2CDC73.91774852
3TRIB33.15713456
4NEK23.12216847
5PKN23.09040566
6MAP3K92.74019718
7MAP3K102.62482249
8EEF2K2.61446612
9STK32.55109553
10TAF12.36738326
11WEE12.24316754
12EIF2AK12.09442464
13TTK2.09213178
14STK102.00177619
15LATS11.97534587
16CDK41.94787723
17PBK1.91256772
18NEK11.86615331
19CDK61.79852557
20MST1R1.78200176
21BUB11.74213214
22BRSK21.70013276
23DMPK1.60686077
24SCYL21.58932361
25PASK1.53653666
26NUAK11.51990260
27PTK61.49718746
28BRD41.49093548
29TRIM281.49069175
30EIF2AK31.47261386
31AURKB1.42907130
32PLK11.41995301
33ALK1.40230205
34SMG11.38630026
35PDGFRA1.34869412
36MAP3K81.31367067
37RIPK11.29258715
38CHEK11.26791255
39ACVR1B1.23256091
40PLK31.23089929
41STK241.22709095
42LRRK21.20718360
43MTOR1.18487548
44RPS6KB21.13866646
45MELK1.13615184
46MKNK11.13198853
47ATR1.12293042
48PAK41.12184124
49CDK71.11831004
50YES11.10710301
51STK41.10706865
52CHEK21.10289999
53BRSK11.07917872
54EIF2AK21.04866612
55TTN1.03500901
56STK38L1.00795721
57MKNK20.96619967
58MET0.95303494
59TSSK60.93018353
60CDK20.89703474
61ATM0.89460810
62SIK30.88178680
63RPS6KA40.84944995
64CAMK1D0.83112444
65ILK0.82886734
66SIK10.82773721
67BCR0.79953685
68MAP3K70.79788141
69FGFR10.78834074
70DYRK30.78666419
71ERBB30.78150599
72CCNB10.76947327
73TGFBR10.76301893
74LATS20.76004623
75CDK90.75986053
76PDGFRB0.75842104
77TYRO30.74373611
78BRAF0.72566845
79ICK0.72129997
80KSR20.71617719
81PRPF4B0.71089686
82STK390.70535630
83CDK10.70152743
84RAF10.70028001
85CAMK1G0.68574345
86CLK10.67160325
87TNIK0.66669399
88PAK20.66457763
89PLK40.64059589
90CASK0.62858341
91SRPK10.62592199
92PIM10.61960196
93PNCK0.58744534
94BMX0.54727225
95ERBB40.53450458
96EPHA20.52031466
97PRKDC0.51440722
98FLT30.51237172
99PAK10.50038361
100FGFR20.49450896
101CSNK1D0.48633483
102FGFR40.48088047
103CDK180.47902048
104MAPK140.46458461
105CDK30.46034380
106DDR20.45652344
107TRPM70.44258668
108AURKA0.44060303
109NLK0.43828066
110UHMK10.43577040
111MARK30.43478226
112NEK60.43361480
113FGFR30.43258788
114KSR10.41914205
115CDK80.41819735
116CDK11A0.41726279
117CDK150.40928497
118DYRK1B0.40666617
119CSNK1E0.40091505
120MINK10.40072794
121RET0.39917923
122HIPK20.39732325
123MAP3K140.39136667
124PTK20.39041994
125MAPK10.38682569
126PLK20.37911695
127CDK140.36750635
128FRK0.36406131
129AKT20.36333704
130GRK60.34917058
131GSK3B0.34654794
132MAP2K20.34330544
133MAP3K20.32756640
134WNK10.31767466
135TAOK10.31185050
136MST40.29813133
137AKT10.28442998
138MAPK100.28006862

Predicted pathways (KEGG)

RankGene SetZ-score
1* Cell cycle_Homo sapiens_hsa041103.09313882
2DNA replication_Homo sapiens_hsa030303.04900764
3RNA transport_Homo sapiens_hsa030132.77614148
4Mismatch repair_Homo sapiens_hsa034302.61886524
5Spliceosome_Homo sapiens_hsa030402.29193578
6mRNA surveillance pathway_Homo sapiens_hsa030152.26230986
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98839157
8Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.86373720
9Adherens junction_Homo sapiens_hsa045201.81922603
10Chronic myeloid leukemia_Homo sapiens_hsa052201.76830997
11Small cell lung cancer_Homo sapiens_hsa052221.76138422
12MicroRNAs in cancer_Homo sapiens_hsa052061.68748253
13Base excision repair_Homo sapiens_hsa034101.61589013
14Oocyte meiosis_Homo sapiens_hsa041141.61435391
15Viral carcinogenesis_Homo sapiens_hsa052031.58287330
16Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.57552019
17p53 signaling pathway_Homo sapiens_hsa041151.54228953
18Endometrial cancer_Homo sapiens_hsa052131.53535876
19mTOR signaling pathway_Homo sapiens_hsa041501.52110918
20Colorectal cancer_Homo sapiens_hsa052101.51279786
21One carbon pool by folate_Homo sapiens_hsa006701.50178748
22Non-homologous end-joining_Homo sapiens_hsa034501.48884960
23Homologous recombination_Homo sapiens_hsa034401.48865741
24Hippo signaling pathway_Homo sapiens_hsa043901.48214720
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47588788
26Nucleotide excision repair_Homo sapiens_hsa034201.38599041
27Fanconi anemia pathway_Homo sapiens_hsa034601.27069795
28HTLV-I infection_Homo sapiens_hsa051661.25518189
29Non-small cell lung cancer_Homo sapiens_hsa052231.25160390
30Pancreatic cancer_Homo sapiens_hsa052121.24734261
31Thyroid cancer_Homo sapiens_hsa052161.24650556
32Proteoglycans in cancer_Homo sapiens_hsa052051.24287021
33Antigen processing and presentation_Homo sapiens_hsa046121.22416177
34RNA degradation_Homo sapiens_hsa030181.20436866
35Vitamin B6 metabolism_Homo sapiens_hsa007501.16918554
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16622914
37Lysine degradation_Homo sapiens_hsa003101.16546901
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15563745
39Prostate cancer_Homo sapiens_hsa052151.11745022
40TGF-beta signaling pathway_Homo sapiens_hsa043501.09647897
41Basal cell carcinoma_Homo sapiens_hsa052171.08457094
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08202931
43Herpes simplex infection_Homo sapiens_hsa051681.05300163
44Epstein-Barr virus infection_Homo sapiens_hsa051691.03710979
45Focal adhesion_Homo sapiens_hsa045101.02813387
46Viral myocarditis_Homo sapiens_hsa054161.02585960
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00464827
48Dorso-ventral axis formation_Homo sapiens_hsa043201.00363969
49Systemic lupus erythematosus_Homo sapiens_hsa053220.97186406
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.96807619
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95561225
52Tight junction_Homo sapiens_hsa045300.94915717
53Renal cell carcinoma_Homo sapiens_hsa052110.93979171
54Bladder cancer_Homo sapiens_hsa052190.91467760
55FoxO signaling pathway_Homo sapiens_hsa040680.91043417
56Acute myeloid leukemia_Homo sapiens_hsa052210.89267398
57Notch signaling pathway_Homo sapiens_hsa043300.89176929
58Hepatitis B_Homo sapiens_hsa051610.88751728
59Pathways in cancer_Homo sapiens_hsa052000.88627925
60Glioma_Homo sapiens_hsa052140.88299241
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.86684985
62Biosynthesis of amino acids_Homo sapiens_hsa012300.86482445
63Basal transcription factors_Homo sapiens_hsa030220.86348813
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85402914
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82321865
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.81273948
67Toxoplasmosis_Homo sapiens_hsa051450.79952558
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78750206
69Hedgehog signaling pathway_Homo sapiens_hsa043400.77908914
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76687085
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75276289
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74199629
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73465906
74Wnt signaling pathway_Homo sapiens_hsa043100.71676833
75AMPK signaling pathway_Homo sapiens_hsa041520.71619717
76Inositol phosphate metabolism_Homo sapiens_hsa005620.71418791
77Melanogenesis_Homo sapiens_hsa049160.70451820
78ECM-receptor interaction_Homo sapiens_hsa045120.68655337
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68235148
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68064679
81VEGF signaling pathway_Homo sapiens_hsa043700.67840372
82Apoptosis_Homo sapiens_hsa042100.66559414
83Platelet activation_Homo sapiens_hsa046110.65569665
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64350098
85T cell receptor signaling pathway_Homo sapiens_hsa046600.63807788
86Long-term potentiation_Homo sapiens_hsa047200.63729878
87Fatty acid biosynthesis_Homo sapiens_hsa000610.60750249
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.60095261
89Insulin resistance_Homo sapiens_hsa049310.58734764
90Insulin signaling pathway_Homo sapiens_hsa049100.58014636
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.57456759
92Prolactin signaling pathway_Homo sapiens_hsa049170.56490157
93HIF-1 signaling pathway_Homo sapiens_hsa040660.56139575
94Estrogen signaling pathway_Homo sapiens_hsa049150.55703220
95Alcoholism_Homo sapiens_hsa050340.55227676
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53723064
97Amoebiasis_Homo sapiens_hsa051460.53234121
98B cell receptor signaling pathway_Homo sapiens_hsa046620.53019697
99Shigellosis_Homo sapiens_hsa051310.52937355
100Leishmaniasis_Homo sapiens_hsa051400.51760230
101Melanoma_Homo sapiens_hsa052180.51217572
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50027860
103Measles_Homo sapiens_hsa051620.49873556
104Gap junction_Homo sapiens_hsa045400.49822661
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49638028
106Carbon metabolism_Homo sapiens_hsa012000.47262408
107Pyruvate metabolism_Homo sapiens_hsa006200.47216194
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46603099
109Steroid biosynthesis_Homo sapiens_hsa001000.46402219
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.45389214
111Pyrimidine metabolism_Homo sapiens_hsa002400.45334955
112TNF signaling pathway_Homo sapiens_hsa046680.44361105
113ErbB signaling pathway_Homo sapiens_hsa040120.40625584
114Selenocompound metabolism_Homo sapiens_hsa004500.39851201
115Choline metabolism in cancer_Homo sapiens_hsa052310.39615958
116Endocytosis_Homo sapiens_hsa041440.39186685
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38989167
118Glucagon signaling pathway_Homo sapiens_hsa049220.38872118
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37736764
120Pentose phosphate pathway_Homo sapiens_hsa000300.37227455
121Axon guidance_Homo sapiens_hsa043600.34707995

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