RAD21L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.96604902
2protein targeting to Golgi (GO:0000042)9.08106343
3establishment of protein localization to Golgi (GO:0072600)8.75379367
4chromosome condensation (GO:0030261)8.59537234
5DNA packaging (GO:0006323)8.55253310
6retrograde transport, vesicle recycling within Golgi (GO:0000301)8.46875621
7microtubule depolymerization (GO:0007019)8.14677522
8plasma membrane fusion (GO:0045026)7.79562137
9microtubule polymerization or depolymerization (GO:0031109)7.58580351
10centriole replication (GO:0007099)7.53001361
11spermatid development (GO:0007286)7.47701020
12sperm capacitation (GO:0048240)7.42423667
13rRNA methylation (GO:0031167)7.11401965
14protein polyglutamylation (GO:0018095)7.03039023
15sperm-egg recognition (GO:0035036)6.94640320
16regulation of centriole replication (GO:0046599)6.82955557
17single strand break repair (GO:0000012)6.71873501
18protein localization to Golgi apparatus (GO:0034067)6.64573630
19centriole assembly (GO:0098534)6.52488936
20* spermatogenesis (GO:0007283)6.43681974
21* male gamete generation (GO:0048232)6.42114109
22binding of sperm to zona pellucida (GO:0007339)6.40660773
23spermatid nucleus differentiation (GO:0007289)6.35189471
24multicellular organism reproduction (GO:0032504)6.33739563
25* gamete generation (GO:0007276)5.96498977
26rRNA modification (GO:0000154)5.90737811
27reproduction (GO:0000003)5.73217262
28calcium ion-dependent exocytosis (GO:0017156)5.71995319
29cell-cell recognition (GO:0009988)5.62672398
30male meiosis I (GO:0007141)5.61131772
31nuclear pore complex assembly (GO:0051292)5.58193953
32response to pheromone (GO:0019236)5.56056176
33synapsis (GO:0007129)5.50264327
34piRNA metabolic process (GO:0034587)5.42754181
35phosphatidylethanolamine biosynthetic process (GO:0006646)5.42453857
36axonemal dynein complex assembly (GO:0070286)5.41181924
37glomerular visceral epithelial cell development (GO:0072015)5.32203725
38microtubule severing (GO:0051013)5.22558263
39phosphatidylethanolamine metabolic process (GO:0046337)5.08698913
40single fertilization (GO:0007338)5.05559479
41microtubule nucleation (GO:0007020)5.01871963
42chromosome organization involved in meiosis (GO:0070192)4.97490417
43cilium or flagellum-dependent cell motility (GO:0001539)4.95436246
44sexual reproduction (GO:0019953)4.93018179
45glomerular epithelial cell development (GO:0072310)4.85462278
46negative regulation of inclusion body assembly (GO:0090084)4.79623061
47male meiosis (GO:0007140)4.75018936
48* multicellular organismal reproductive process (GO:0048609)4.74527294
49DNA methylation involved in gamete generation (GO:0043046)4.72049223
50synaptonemal complex assembly (GO:0007130)4.70687269
51regulation of Rab GTPase activity (GO:0032313)4.65138460
52positive regulation of Rab GTPase activity (GO:0032851)4.65138460
53regulation of cilium movement (GO:0003352)4.62400611
54germ cell development (GO:0007281)4.60795674
55RNA destabilization (GO:0050779)4.58225550
56* fertilization (GO:0009566)4.53698109
57motile cilium assembly (GO:0044458)4.53354249
58epithelial cilium movement (GO:0003351)4.44657833
59meiosis I (GO:0007127)4.38350344
60cellular process involved in reproduction in multicellular organism (GO:0022412)4.38317684
61regulation of meiosis I (GO:0060631)4.36403964
62nucleus organization (GO:0006997)4.28348083
63nuclear pore organization (GO:0006999)4.24548778
64pore complex assembly (GO:0046931)4.24212530
65synaptonemal complex organization (GO:0070193)4.16940615
66cell wall macromolecule catabolic process (GO:0016998)4.16438838
67multicellular organismal movement (GO:0050879)4.08844209
68musculoskeletal movement (GO:0050881)4.08844209
69cell wall macromolecule metabolic process (GO:0044036)4.08336070
70meiotic nuclear division (GO:0007126)4.02151214
71intra-Golgi vesicle-mediated transport (GO:0006891)3.83225801
72regulation of transcription involved in cell fate commitment (GO:0060850)3.77516047
73cilium movement (GO:0003341)3.72205160
74Golgi to endosome transport (GO:0006895)3.67824747
75membrane protein intracellular domain proteolysis (GO:0031293)3.59255859
76glycerol ether metabolic process (GO:0006662)3.50612951
77chromatin silencing (GO:0006342)3.48600334
78DNA synthesis involved in DNA repair (GO:0000731)3.43770332
79histone H3-K9 demethylation (GO:0033169)3.42688927
80regulation of inclusion body assembly (GO:0090083)3.28231717
81* meiotic cell cycle process (GO:1903046)3.26330889
82cellular ketone body metabolic process (GO:0046950)3.24518036
83protein depolymerization (GO:0051261)3.24419190
84regulation of centrosome duplication (GO:0010824)3.21674915
85resolution of meiotic recombination intermediates (GO:0000712)3.21354540
86ether metabolic process (GO:0018904)3.20712661
87organic cation transport (GO:0015695)3.20501943
88acrosome assembly (GO:0001675)3.15925828
89DNA conformation change (GO:0071103)3.14212840
90homeostasis of number of cells within a tissue (GO:0048873)3.13298625
91ventricular system development (GO:0021591)3.11653398
92centrosome duplication (GO:0051298)3.08644977
93tRNA methylation (GO:0030488)3.01263978
94histone exchange (GO:0043486)3.00947070
95RNA localization (GO:0006403)2.97563582
96regulation of microtubule-based movement (GO:0060632)2.97303652
97detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.96067964
98multicellular organismal development (GO:0007275)2.92365047
99sperm motility (GO:0030317)11.1919712
100fusion of sperm to egg plasma membrane (GO:0007342)10.3327668

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.05419073
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.91607347
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.09222964
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.95056434
5EZH2_22144423_ChIP-Seq_EOC_Human2.62198756
6FUS_26573619_Chip-Seq_HEK293_Human2.52361979
7IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.40951975
8CBP_20019798_ChIP-Seq_JUKART_Human2.40951975
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.32441756
10TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32211783
11POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.32211783
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.24412372
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22750986
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.13421272
15ER_23166858_ChIP-Seq_MCF-7_Human1.94854517
16UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.86500612
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83806176
18* RAC3_21632823_ChIP-Seq_H3396_Human1.77161638
19VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.76369407
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75098377
21ERA_21632823_ChIP-Seq_H3396_Human1.74981790
22SMAD4_21741376_ChIP-Seq_EPCs_Human1.74325961
23ELF1_20517297_ChIP-Seq_JURKAT_Human1.73920612
24EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.72062342
25WDR5_24793694_ChIP-Seq_LNCAP_Human1.69779879
26MYC_19829295_ChIP-Seq_ESCs_Human1.68379669
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67002269
28NANOG_20526341_ChIP-Seq_ESCs_Human1.63817741
29ARNT_22903824_ChIP-Seq_MCF-7_Human1.61751005
30ZNF274_21170338_ChIP-Seq_K562_Hela1.59781784
31PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.58740251
32HNFA_21074721_ChIP-Seq_CACO-2_Human1.57253860
33EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.55354841
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53945820
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53891026
36RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.53763634
37CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.52892003
38ERG_20517297_ChIP-Seq_VCAP_Human1.51773315
39CBX2_22325352_ChIP-Seq_293T-Rex_Human1.51378668
40RBPJ_21746931_ChIP-Seq_IB4_Human1.51203888
41VDR_22108803_ChIP-Seq_LS180_Human1.49374805
42NFYB_21822215_ChIP-Seq_K562_Human1.49026165
43ETV1_20927104_ChIP-Seq_GIST48_Human1.45939282
44YY1_22570637_ChIP-Seq_MALME-3M_Human1.45351159
45TBL1_22424771_ChIP-Seq_293T_Human1.44531104
46TAF2_19829295_ChIP-Seq_ESCs_Human1.43769256
47PHF8_20622853_ChIP-Seq_HELA_Human1.40655962
48RUNX1_26923725_Chip-Seq_HPCs_Mouse1.40336527
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39564248
50DROSHA_22980978_ChIP-Seq_HELA_Human1.39176442
51P300_19829295_ChIP-Seq_ESCs_Human1.38568373
52OCT4_20526341_ChIP-Seq_ESCs_Human1.38132828
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.37994874
54TP53_18474530_ChIP-ChIP_U2OS_Human1.37345420
55AR_25329375_ChIP-Seq_VCAP_Human1.36843135
56STAT3_23295773_ChIP-Seq_U87_Human1.36556630
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.36129368
58SMC4_20622854_ChIP-Seq_HELA_Human1.34914915
59PHF8_20622854_ChIP-Seq_HELA_Human1.33713882
60CEBPB_22108803_ChIP-Seq_LS180_Human1.30177567
61BCL6_27268052_Chip-Seq_Bcells_Human1.30090295
62KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28690060
63CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28041963
64CTCF_20526341_ChIP-Seq_ESCs_Human1.26807451
65SMAD3_21741376_ChIP-Seq_ESCs_Human1.26736515
66CTCF_27219007_Chip-Seq_Bcells_Human1.25997862
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25682727
68P68_20966046_ChIP-Seq_HELA_Human1.25596988
69TP63_22573176_ChIP-Seq_HFKS_Human1.24055204
70SOX2_22085726_ChIP-Seq_NPCs_Mouse1.22411343
71BCOR_27268052_Chip-Seq_Bcells_Human1.22283914
72E2F1_20622854_ChIP-Seq_HELA_Human1.22122280
73PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.22066460
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21277840
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20869816
76TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20752652
77GATA6_21074721_ChIP-Seq_CACO-2_Human1.19061215
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.18874639
79RUNX2_22187159_ChIP-Seq_PCA_Human1.17464648
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16797492
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.16749149
82NFYA_21822215_ChIP-Seq_K562_Human1.15780794
83KLF5_25053715_ChIP-Seq_YYC3_Human1.15377346
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15314718
85P53_21459846_ChIP-Seq_SAOS-2_Human1.14851249
86HOXB7_26014856_ChIP-Seq_BT474_Human1.14203271
87JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13013267
88TAF15_26573619_Chip-Seq_HEK293_Human1.12953395
89E2F1_17053090_ChIP-ChIP_MCF-7_Human1.10310967
90CJUN_26792858_Chip-Seq_BT549_Human1.10168577
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.09067330
92KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.08791386
93* SMAD4_21799915_ChIP-Seq_A2780_Human1.08599483
94ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07816231
95SOX2_19829295_ChIP-Seq_ESCs_Human1.07485757
96NANOG_19829295_ChIP-Seq_ESCs_Human1.07485757
97TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.07368144
98SMAD4_21741376_ChIP-Seq_HESCs_Human1.04781002
99SALL4_22934838_ChIP-ChIP_CD34+_Human1.04603957
100FOXH1_21741376_ChIP-Seq_EPCs_Human1.04473834

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology5.57931716
2MP0005377_hearing/vestibular/ear_phenot5.57931716
3MP0003698_abnormal_male_reproductive4.59662688
4MP0001929_abnormal_gametogenesis4.41867054
5MP0005670_abnormal_white_adipose4.15752362
6MP0001348_abnormal_lacrimal_gland3.59505427
7MP0008877_abnormal_DNA_methylation3.28040214
8MP0002210_abnormal_sex_determination2.83485976
9MP0002161_abnormal_fertility/fecundity2.60554283
10MP0003718_maternal_effect2.44581270
11MP0005451_abnormal_body_composition2.23861080
12MP0001145_abnormal_male_reproductive2.15235608
13MP0003646_muscle_fatigue2.03837396
14MP0000678_abnormal_parathyroid_gland2.03388926
15MP0000653_abnormal_sex_gland2.01583719
16MP0005410_abnormal_fertilization10.8866754
17MP0005379_endocrine/exocrine_gland_phen1.99525104
18MP0001485_abnormal_pinna_reflex1.88665135
19MP0005310_abnormal_salivary_gland1.82014222
20MP0003879_abnormal_hair_cell1.70388333
21MP0001486_abnormal_startle_reflex1.48405572
22MP0005423_abnormal_somatic_nervous1.38546418
23MP0004233_abnormal_muscle_weight1.36123755
24MP0002282_abnormal_trachea_morphology1.29590632
25MP0009053_abnormal_anal_canal1.25053516
26MP0004742_abnormal_vestibular_system1.19074031
27MP0004957_abnormal_blastocyst_morpholog1.18202171
28MP0003077_abnormal_cell_cycle1.14683301
29MP0005395_other_phenotype1.14542705
30MP0002132_abnormal_respiratory_system1.09995720
31MP0009697_abnormal_copulation1.09009343
32MP0004510_myositis1.07742238
33MP0008058_abnormal_DNA_repair1.07370743
34MP0002234_abnormal_pharynx_morphology1.06534168
35MP0001765_abnormal_ion_homeostasis1.06315288
36MP0001963_abnormal_hearing_physiology1.06024564
37MP0000534_abnormal_ureter_morphology1.05255838
38MP0005083_abnormal_biliary_tract0.94935365
39MP0004859_abnormal_synaptic_plasticity0.90168523
40MP0004036_abnormal_muscle_relaxation0.85702387
41MP0005551_abnormal_eye_electrophysiolog0.85199295
42MP0005666_abnormal_adipose_tissue0.82973056
43MP0002735_abnormal_chemical_nociception0.82062014
44MP0009115_abnormal_fat_cell0.81193881
45MP0004084_abnormal_cardiac_muscle0.78427664
46MP0002249_abnormal_larynx_morphology0.76591402
47MP0000026_abnormal_inner_ear0.76579393
48MP0002127_abnormal_cardiovascular_syste0.74917314
49MP0004085_abnormal_heartbeat0.74524907
50MP0001968_abnormal_touch/_nociception0.74227694
51MP0010307_abnormal_tumor_latency0.71460140
52MP0000003_abnormal_adipose_tissue0.71259635
53MP0003950_abnormal_plasma_membrane0.71082882
54MP0005167_abnormal_blood-brain_barrier0.70823488
55MP0005253_abnormal_eye_physiology0.70438876
56MP0003699_abnormal_female_reproductive0.68259605
57MP0008995_early_reproductive_senescence0.67492161
58MP0002229_neurodegeneration0.65389802
59MP0005375_adipose_tissue_phenotype0.65053580
60MP0000955_abnormal_spinal_cord0.64916498
61MP0005623_abnormal_meninges_morphology0.64085040
62MP0005408_hypopigmentation0.62815630
63MP0003011_delayed_dark_adaptation0.60371463
64MP0000230_abnormal_systemic_arterial0.60371389
65MP0001879_abnormal_lymphatic_vessel0.59970867
66MP0002067_abnormal_sensory_capabilities0.59533148
67MP0004782_abnormal_surfactant_physiolog0.59522858
68MP0008007_abnormal_cellular_replicative0.58306010
69MP0001119_abnormal_female_reproductive0.57426175
70MP0009780_abnormal_chondrocyte_physiolo0.51735563
71MP0002138_abnormal_hepatobiliary_system0.51342360
72MP0001299_abnormal_eye_distance/0.50468480
73MP0001984_abnormal_olfaction0.49022546
74MP0001905_abnormal_dopamine_level0.48757382
75MP0002733_abnormal_thermal_nociception0.47973529
76MP0002160_abnormal_reproductive_system0.47793249
77MP0005636_abnormal_mineral_homeostasis0.47636441
78MP0003936_abnormal_reproductive_system0.43752068
79MP0002557_abnormal_social/conspecific_i0.43125449
80MP0003385_abnormal_body_wall0.43067818
81MP0002269_muscular_atrophy0.43033058
82MP0010368_abnormal_lymphatic_system0.42206302
83MP0002085_abnormal_embryonic_tissue0.42149171
84MP0005248_abnormal_Harderian_gland0.41201926
85MP0006276_abnormal_autonomic_nervous0.40455509
86MP0008775_abnormal_heart_ventricle0.40069349
87MP0005397_hematopoietic_system_phenotyp0.39888833
88MP0001545_abnormal_hematopoietic_system0.39888833
89MP0000013_abnormal_adipose_tissue0.38879311
90MP0000681_abnormal_thyroid_gland0.38676108
91MP0005332_abnormal_amino_acid0.37263294
92MP0003693_abnormal_embryo_hatching0.36289331
93MP0005084_abnormal_gallbladder_morpholo0.36199391
94MP0005535_abnormal_body_temperature0.34886702
95MP0002572_abnormal_emotion/affect_behav0.33516274
96MP0008770_decreased_survivor_rate0.33211760
97MP0003935_abnormal_craniofacial_develop0.33028243
98MP0002168_other_aberrant_phenotype0.32304577
99MP0008932_abnormal_embryonic_tissue0.32185848
100MP0008569_lethality_at_weaning0.31830391

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial nephritis (HP:0001970)7.57880610
2Severe visual impairment (HP:0001141)6.36258276
3Chronic hepatic failure (HP:0100626)6.21999482
4Asymmetric septal hypertrophy (HP:0001670)6.09864501
5Absent/shortened dynein arms (HP:0200106)5.58564512
6Dynein arm defect of respiratory motile cilia (HP:0012255)5.58564512
7Cone-rod dystrophy (HP:0000548)5.07093806
8Male infertility (HP:0003251)4.76119057
9Menstrual irregularities (HP:0000858)4.40014401
10Resting tremor (HP:0002322)4.39251911
11Aplasia/Hypoplasia of the earlobes (HP:0009906)4.33430908
12Hyperkalemia (HP:0002153)4.22557444
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.20294471
14Infertility (HP:0000789)4.15353797
15Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.07746576
16Abnormal respiratory motile cilium physiology (HP:0012261)4.04110961
17Abnormal ciliary motility (HP:0012262)3.97742415
18Hypoalphalipoproteinemia (HP:0003233)3.94567776
19Abnormality of dental color (HP:0011073)3.93775261
20Abnormality of macular pigmentation (HP:0008002)3.85318070
21Attenuation of retinal blood vessels (HP:0007843)3.85010018
22Bony spicule pigmentary retinopathy (HP:0007737)3.84820390
23Bell-shaped thorax (HP:0001591)3.78365008
24Progressive sensorineural hearing impairment (HP:0000408)3.72138055
25Nasal polyposis (HP:0100582)3.67550501
26Renovascular hypertension (HP:0100817)3.65127869
27Amelogenesis imperfecta (HP:0000705)3.57799398
28Abnormal respiratory epithelium morphology (HP:0012253)3.51045069
29Abnormal respiratory motile cilium morphology (HP:0005938)3.51045069
30Truncal obesity (HP:0001956)3.45480788
31Abnormal spermatogenesis (HP:0008669)3.40004458
32Tubulointerstitial abnormality (HP:0001969)3.39966289
33Stage 5 chronic kidney disease (HP:0003774)3.33107991
34Enlarged epiphyses (HP:0010580)3.22001506
35Insulin-resistant diabetes mellitus (HP:0000831)3.17470177
36Subcapsular cataract (HP:0000523)3.12352519
37Hypoplasia of the thymus (HP:0000778)3.09727115
38Impulsivity (HP:0100710)3.05652283
39Nephronophthisis (HP:0000090)3.05604296
40Progressive cerebellar ataxia (HP:0002073)3.02933884
41Abnormality of the nasal mucosa (HP:0000433)2.99541291
42Azoospermia (HP:0000027)2.96087583
43Portal hypertension (HP:0001409)2.93453332
44Hypoplastic ischia (HP:0003175)2.79696632
45Potter facies (HP:0002009)2.76687897
46Facial shape deformation (HP:0011334)2.76687897
47Abnormality of the costochondral junction (HP:0000919)2.73908643
48Abnormality of the hepatic vasculature (HP:0006707)2.72686196
49Postural instability (HP:0002172)2.71816321
50Intellectual disability, moderate (HP:0002342)2.70881574
51Increased purine levels (HP:0004368)2.70463297
52Hyperuricemia (HP:0002149)2.70463297
53Spontaneous abortion (HP:0005268)2.67771552
54Abnormality of the renal medulla (HP:0100957)2.65723072
55Focal segmental glomerulosclerosis (HP:0000097)2.62286135
56Progressive hearing impairment (HP:0001730)2.56715121
57Abnormality of the ischium (HP:0003174)2.52219595
58Upper limb muscle weakness (HP:0003484)2.47839144
59Flattened epiphyses (HP:0003071)2.45478331
60Sandal gap (HP:0001852)2.40271601
61Tubular atrophy (HP:0000092)2.34345724
62Rhinitis (HP:0012384)2.34011391
63Osteomalacia (HP:0002749)2.32201074
64Hypophosphatemic rickets (HP:0004912)2.30028812
65Convex nasal ridge (HP:0000444)2.17488081
66Glomerulosclerosis (HP:0000096)2.16313449
67Horizontal nystagmus (HP:0000666)2.16020410
68Hypolipoproteinemia (HP:0010981)2.09385005
69Ventricular tachycardia (HP:0004756)2.07399119
70Chronic bronchitis (HP:0004469)2.05463041
71Abnormality of potassium homeostasis (HP:0011042)2.05319538
72Abnormal urine output (HP:0012590)2.04147595
73Polydipsia (HP:0001959)1.98263272
74Abnormal drinking behavior (HP:0030082)1.98263272
75Abnormal rod and cone electroretinograms (HP:0008323)1.97311280
76Hypoalbuminemia (HP:0003073)1.92896502
77Abnormal albumin level (HP:0012116)1.92896502
78Hand muscle atrophy (HP:0009130)1.87916036
79Insulin resistance (HP:0000855)1.86977287
80Unilateral renal agenesis (HP:0000122)1.86547264
81Bradycardia (HP:0001662)1.85993263
82Hypergonadotropic hypogonadism (HP:0000815)1.84741205
83Flat capital femoral epiphysis (HP:0003370)1.80917484
84Abnormality of renal excretion (HP:0011036)1.80538521
85Obsessive-compulsive behavior (HP:0000722)1.80509399
86Abnormality of purine metabolism (HP:0004352)1.79862583
87Abnormality of the epiphysis of the femoral head (HP:0010574)1.78724336
88Polar cataract (HP:0010696)1.78690747
89Acanthosis nigricans (HP:0000956)1.78076011
90Scotoma (HP:0000575)1.76565309
91Widely patent fontanelles and sutures (HP:0004492)1.75424474
92Generalized aminoaciduria (HP:0002909)1.73091885
93Congenital sensorineural hearing impairment (HP:0008527)1.71397639
94Underdeveloped nasal alae (HP:0000430)1.71009887
95Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.69743463
96Polyuria (HP:0000103)1.66908788
97Abnormality of femoral epiphyses (HP:0006499)1.66652484
98Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.66652484
99Duodenal stenosis (HP:0100867)1.66023645
100Small intestinal stenosis (HP:0012848)1.66023645

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.48835726
2BRD44.36806111
3PLK24.12517915
4TESK13.94300480
5PNCK3.53624078
6DDR23.08106280
7PIK3CG3.00218547
8STK38L2.68087020
9CAMK1G2.42754263
10STK382.40834816
11MAP4K22.10976746
12PLK410.2040282
13PRKD31.84882419
14TYRO31.81187675
15MST1R1.77683674
16NEK61.69911173
17PTK2B1.54375210
18CDK121.47614208
19PDK11.38473746
20PDPK11.36440109
21MAPK151.19607112
22AKT31.05009198
23CDK71.00959312
24WNK10.95106922
25TIE10.82787089
26CDK190.81222952
27BRSK10.80362712
28BRAF0.77865778
29KSR20.77830382
30PRKG20.76358523
31PDK20.75135584
32MET0.73773641
33CAMK1D0.70991280
34NTRK30.69996817
35DYRK1B0.66777738
36MAP3K90.65041013
37BRSK20.61923060
38LATS20.54047633
39MAP3K20.50676752
40PRKG10.49693908
41MAP3K110.48807775
42CHEK10.47334343
43SIK20.45907847
44CDK20.45607592
45CDK10.44885370
46RPS6KA20.43440589
47MAPK10.38871500
48MAP3K80.38870742
49MTOR0.38577950
50CAMK10.38501502
51MAP2K20.36913432
52PLK10.36569842
53PRKAA20.36051997
54TESK20.35350993
55LATS10.35059103
56ROCK10.35040189
57GSK3B0.34830186
58CDK30.34462769
59RPS6KA10.30146418
60NEK20.29189593
61PRKCG0.22905874
62BMPR1B0.22233021
63ARAF0.22070529
64MAPK140.19839713
65CDK80.19688256
66STK30.18801120
67STK390.18670132
68SGK10.18617796
69EPHA20.18461607
70PRKCB0.18443229
71MAP3K10.18388488
72MAPK80.18220039
73WNK40.18116103
74OXSR10.17906708
75TRPM70.17752990
76EEF2K0.15549281
77MAPK100.15215649
78FRK0.14771904
79AKT10.14482108
80FER0.14271193
81MAPK110.13885830
82PRKCZ0.13298826
83DYRK30.13294234
84MAP3K40.12683948
85FGFR10.12452920
86TTK0.12060092
87AURKA0.11845305
88BLK0.11443760
89PAK20.10996104
90PRKACB0.10752643
91MAPKAPK50.10151278
92PAK10.10111647
93JAK30.08965193
94ACVR1B0.08915435
95CAMK40.07311428
96MAP2K10.07171794
97RET0.06870695
98MUSK0.05484282
99ATM0.05374910
100CHEK20.05288521

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.51787356
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.85899212
3Olfactory transduction_Homo sapiens_hsa047404.39912303
4RNA transport_Homo sapiens_hsa030133.10880134
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.67660828
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.58428333
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.95623604
8Taste transduction_Homo sapiens_hsa047421.89959120
9Dorso-ventral axis formation_Homo sapiens_hsa043201.87736663
10Glycerophospholipid metabolism_Homo sapiens_hsa005641.83076801
11Phenylalanine metabolism_Homo sapiens_hsa003601.76589584
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.63925331
13Oocyte meiosis_Homo sapiens_hsa041141.54221512
14Butanoate metabolism_Homo sapiens_hsa006501.52069889
15Fanconi anemia pathway_Homo sapiens_hsa034601.50088582
16Fatty acid metabolism_Homo sapiens_hsa012121.47025589
17Fatty acid degradation_Homo sapiens_hsa000711.43542168
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.40473104
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.36048052
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.34643709
21Type II diabetes mellitus_Homo sapiens_hsa049301.33630666
22Basal transcription factors_Homo sapiens_hsa030221.32512073
23Inositol phosphate metabolism_Homo sapiens_hsa005621.29748614
24Selenocompound metabolism_Homo sapiens_hsa004501.29335529
25ECM-receptor interaction_Homo sapiens_hsa045121.21082180
26Homologous recombination_Homo sapiens_hsa034401.20027714
27Protein digestion and absorption_Homo sapiens_hsa049741.12439366
28Phototransduction_Homo sapiens_hsa047441.07232161
29Adipocytokine signaling pathway_Homo sapiens_hsa049201.05142126
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.04800640
31ABC transporters_Homo sapiens_hsa020101.04065005
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03956112
33Calcium signaling pathway_Homo sapiens_hsa040201.02635561
34VEGF signaling pathway_Homo sapiens_hsa043700.99799315
35Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98077801
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95356805
37Synaptic vesicle cycle_Homo sapiens_hsa047210.95330180
38Endocytosis_Homo sapiens_hsa041440.94706975
39mRNA surveillance pathway_Homo sapiens_hsa030150.92736570
40Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90770147
41Cell cycle_Homo sapiens_hsa041100.90331093
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89558082
43Arginine biosynthesis_Homo sapiens_hsa002200.87823765
44Primary bile acid biosynthesis_Homo sapiens_hsa001200.82883645
45Purine metabolism_Homo sapiens_hsa002300.81918828
46Base excision repair_Homo sapiens_hsa034100.81356644
47Salivary secretion_Homo sapiens_hsa049700.77543130
48Non-homologous end-joining_Homo sapiens_hsa034500.76621712
49cAMP signaling pathway_Homo sapiens_hsa040240.75026463
50Nucleotide excision repair_Homo sapiens_hsa034200.74660838
51Sulfur relay system_Homo sapiens_hsa041220.73679815
52Arginine and proline metabolism_Homo sapiens_hsa003300.71593030
53Tyrosine metabolism_Homo sapiens_hsa003500.69953812
54Glutamatergic synapse_Homo sapiens_hsa047240.63313571
55Circadian entrainment_Homo sapiens_hsa047130.62854827
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60255463
57Hedgehog signaling pathway_Homo sapiens_hsa043400.60125706
58Morphine addiction_Homo sapiens_hsa050320.58900547
59Renin-angiotensin system_Homo sapiens_hsa046140.56832567
60Pancreatic secretion_Homo sapiens_hsa049720.54583413
61Influenza A_Homo sapiens_hsa051640.53834606
62Adherens junction_Homo sapiens_hsa045200.49905636
63Nicotine addiction_Homo sapiens_hsa050330.49665862
64Focal adhesion_Homo sapiens_hsa045100.49387719
65Tight junction_Homo sapiens_hsa045300.46941222
66Glycerolipid metabolism_Homo sapiens_hsa005610.46161766
67Cardiac muscle contraction_Homo sapiens_hsa042600.46152385
68Estrogen signaling pathway_Homo sapiens_hsa049150.45780103
69Serotonergic synapse_Homo sapiens_hsa047260.45221869
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44594780
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42973433
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42458996
73Fat digestion and absorption_Homo sapiens_hsa049750.41480131
74mTOR signaling pathway_Homo sapiens_hsa041500.40271303
75PPAR signaling pathway_Homo sapiens_hsa033200.40203610
76Gastric acid secretion_Homo sapiens_hsa049710.39242694
77MAPK signaling pathway_Homo sapiens_hsa040100.39030132
78Biosynthesis of amino acids_Homo sapiens_hsa012300.38871932
79Vitamin B6 metabolism_Homo sapiens_hsa007500.38324992
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37020868
81Long-term potentiation_Homo sapiens_hsa047200.36614209
82Propanoate metabolism_Homo sapiens_hsa006400.34966053
83Mismatch repair_Homo sapiens_hsa034300.34178607
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.33772314
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32903830
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32293614
87Nitrogen metabolism_Homo sapiens_hsa009100.32014249
88Bile secretion_Homo sapiens_hsa049760.31163802
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30865857
90Prostate cancer_Homo sapiens_hsa052150.30193605
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28256354
92DNA replication_Homo sapiens_hsa030300.28181587
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28065224
94Acute myeloid leukemia_Homo sapiens_hsa052210.28006359
95Retinol metabolism_Homo sapiens_hsa008300.27119229
96Lysine degradation_Homo sapiens_hsa003100.26870729
97Pyrimidine metabolism_Homo sapiens_hsa002400.26672994
98Huntingtons disease_Homo sapiens_hsa050160.26667188
99Cholinergic synapse_Homo sapiens_hsa047250.26202569
100Antigen processing and presentation_Homo sapiens_hsa046120.25639712

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