RAD23A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX biosynthetic process (GO:0006782)9.30749665
2porphyrin-containing compound biosynthetic process (GO:0006779)7.84062993
3heme biosynthetic process (GO:0006783)7.75118679
4tetrapyrrole biosynthetic process (GO:0033014)6.92611512
5porphyrin-containing compound metabolic process (GO:0006778)6.33256484
6heme metabolic process (GO:0042168)6.29404118
7sarcoplasmic reticulum calcium ion transport (GO:0070296)5.97117874
8skeletal muscle contraction (GO:0003009)5.73975898
9actin-mediated cell contraction (GO:0070252)5.57678075
10regulation of skeletal muscle contraction (GO:0014819)5.31872333
11creatine metabolic process (GO:0006600)5.19966041
12erythrocyte maturation (GO:0043249)4.96295261
13erythrocyte development (GO:0048821)4.86647278
14striated muscle contraction (GO:0006941)4.38498143
15tetrapyrrole metabolic process (GO:0033013)4.16811597
16gluconeogenesis (GO:0006094)4.15776878
17negative regulation of cell size (GO:0045792)4.07036133
18actin filament-based movement (GO:0030048)3.94572717
19response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.90052949
20hemoglobin metabolic process (GO:0020027)3.89106143
21hexose biosynthetic process (GO:0019319)3.80230403
22pigment biosynthetic process (GO:0046148)3.79232293
23IMP biosynthetic process (GO:0006188)3.79053213
24positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.71110390
25monosaccharide biosynthetic process (GO:0046364)3.69130836
26myofibril assembly (GO:0030239)3.60577135
27glycogen catabolic process (GO:0005980)3.54231000
28negative regulation of necroptotic process (GO:0060546)3.52481385
29negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.51626731
30glycolytic process (GO:0006096)3.51032232
31oxygen transport (GO:0015671)3.50391780
32response to lead ion (GO:0010288)3.50385514
33skeletal muscle fiber development (GO:0048741)3.49971625
34positive regulation of myotube differentiation (GO:0010831)3.49074246
35glucan biosynthetic process (GO:0009250)3.48538871
36glycogen biosynthetic process (GO:0005978)3.48538871
37regulation of relaxation of muscle (GO:1901077)3.48354927
38response to methylmercury (GO:0051597)3.47549959
39response to muscle activity (GO:0014850)3.44906470
40IMP metabolic process (GO:0046040)3.42577506
41cardiac muscle contraction (GO:0060048)3.41585761
42folic acid-containing compound biosynthetic process (GO:0009396)3.41218423
43response to insecticide (GO:0017085)3.39100065
44skeletal muscle adaptation (GO:0043501)3.36678690
45purine nucleotide salvage (GO:0032261)3.34048212
46fructose metabolic process (GO:0006000)3.32049716
47DNA deamination (GO:0045006)3.30928595
48negative regulation of erythrocyte differentiation (GO:0045647)3.30871087
49tricarboxylic acid cycle (GO:0006099)3.25623893
50oxaloacetate metabolic process (GO:0006107)3.23115043
51myeloid cell development (GO:0061515)3.22243678
52glucan catabolic process (GO:0009251)3.21675651
53pigment metabolic process (GO:0042440)3.20308314
54oxidative phosphorylation (GO:0006119)3.13711161
55DNA strand elongation involved in DNA replication (GO:0006271)3.11316170
56positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.10273376
57gas transport (GO:0015669)3.10108009
58negative regulation of potassium ion transmembrane transport (GO:1901380)3.09517533
59lysine metabolic process (GO:0006553)3.04320294
60lysine catabolic process (GO:0006554)3.04320294
613-UTR-mediated mRNA stabilization (GO:0070935)3.02787919
622-oxoglutarate metabolic process (GO:0006103)3.02448021
63purine-containing compound salvage (GO:0043101)3.01610552
64muscle contraction (GO:0006936)2.99911029
65proline biosynthetic process (GO:0006561)2.99310998
66negative regulation of necrotic cell death (GO:0060547)2.99040915
67regulation of response to osmotic stress (GO:0047484)2.96305346
68GDP-mannose metabolic process (GO:0019673)2.96118476
69NADH metabolic process (GO:0006734)2.95708034
70deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.94529089
71DNA replication initiation (GO:0006270)2.93938068
72erythrocyte differentiation (GO:0030218)2.93663488
73DNA strand elongation (GO:0022616)2.93024352
74regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.91854674
75cellular polysaccharide catabolic process (GO:0044247)2.90088207
76modulation by virus of host process (GO:0019054)2.87635262
77telomere maintenance via semi-conservative replication (GO:0032201)2.85741889
78regulation of translational termination (GO:0006449)2.85600789
79mitotic chromosome condensation (GO:0007076)2.84844903
80COPI coating of Golgi vesicle (GO:0048205)2.83410209
81Golgi transport vesicle coating (GO:0048200)2.83410209
82regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.83409919
83DNA unwinding involved in DNA replication (GO:0006268)2.83238561
84DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.79451399
85ribosomal small subunit assembly (GO:0000028)2.79103165
86nuclear envelope reassembly (GO:0031468)2.78920232
87mitotic nuclear envelope reassembly (GO:0007084)2.78920232
88negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.78899816
89muscle cell cellular homeostasis (GO:0046716)2.78799522
90myotube cell development (GO:0014904)2.78424486
91protein maturation by protein folding (GO:0022417)2.78258935
92cardiac myofibril assembly (GO:0055003)2.77930788
93ribosomal small subunit biogenesis (GO:0042274)2.77097203
94pyrimidine nucleoside salvage (GO:0043097)2.76240959
95pyrimidine-containing compound salvage (GO:0008655)2.76240959
96cellular hyperosmotic response (GO:0071474)2.76085240
97sequestering of actin monomers (GO:0042989)2.75160299
98glucose metabolic process (GO:0006006)2.74235300
99muscle filament sliding (GO:0030049)2.72925139
100actin-myosin filament sliding (GO:0033275)2.72925139
101maternal placenta development (GO:0001893)2.72242691
102iron-sulfur cluster assembly (GO:0016226)2.71771684
103metallo-sulfur cluster assembly (GO:0031163)2.71771684
104glycogen metabolic process (GO:0005977)2.70616485
105pteridine-containing compound biosynthetic process (GO:0042559)2.68132279
106modulation by symbiont of host cellular process (GO:0044068)2.67942741
107cofactor biosynthetic process (GO:0051188)2.67339382
108retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.67111605
109endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.66973471
110protein autoprocessing (GO:0016540)2.64870629
111formation of translation preinitiation complex (GO:0001731)2.64463532
112DNA replication-dependent nucleosome organization (GO:0034723)2.62012793
113DNA replication-dependent nucleosome assembly (GO:0006335)2.62012793
114glucan metabolic process (GO:0044042)2.61700866
115cellular glucan metabolic process (GO:0006073)2.61700866
116nucleotide salvage (GO:0043173)2.61646236
117muscle system process (GO:0003012)2.61242737
118response to inactivity (GO:0014854)2.60884238
119DNA damage response, signal transduction resulting in transcription (GO:0042772)2.58885053
120polysaccharide catabolic process (GO:0000272)2.58224383
121negative regulation of skeletal muscle tissue development (GO:0048642)2.57188076
122L-alpha-amino acid transmembrane transport (GO:1902475)2.55670640
123nucleobase-containing small molecule interconversion (GO:0015949)2.55178947
124valine metabolic process (GO:0006573)2.54260229
125actomyosin structure organization (GO:0031032)2.53748136
126DNA replication checkpoint (GO:0000076)2.53100015
127tricarboxylic acid metabolic process (GO:0072350)2.52367281
128aspartate family amino acid catabolic process (GO:0009068)2.52300240
129activation of MAPKKK activity (GO:0000185)2.50602698
130regulation of necroptotic process (GO:0060544)2.49010346
131embryonic hemopoiesis (GO:0035162)2.46706250
132negative regulation of B cell apoptotic process (GO:0002903)2.46551822
133sarcomere organization (GO:0045214)2.46320686
134regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.44813799
135translational elongation (GO:0006414)2.43186076
136DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.43066409
137response to arsenic-containing substance (GO:0046685)2.42284445
138platelet formation (GO:0030220)2.40943317
139galactose catabolic process (GO:0019388)2.40850817
140protein retention in ER lumen (GO:0006621)2.39658211
141signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.38633708
142intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.38633708
143pentose-phosphate shunt (GO:0006098)2.38154192
144AMP metabolic process (GO:0046033)2.36977337
145antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.36120980
146antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.36120980
147signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.34392197
148signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.34392197
149signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.34392197
150viral transcription (GO:0019083)2.34208848
151signal transduction involved in DNA integrity checkpoint (GO:0072401)2.32960351
152signal transduction involved in DNA damage checkpoint (GO:0072422)2.32960351
153tetrahydrofolate metabolic process (GO:0046653)2.32078038
154megakaryocyte development (GO:0035855)2.31070684
155proteasome assembly (GO:0043248)2.30454353
156negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.30044883
157mitotic sister chromatid segregation (GO:0000070)2.29771363
158cellular response to dexamethasone stimulus (GO:0071549)2.28674164
159regulation of translational fidelity (GO:0006450)2.28660818
160very-low-density lipoprotein particle assembly (GO:0034379)2.28342721
161mitochondrial fusion (GO:0008053)2.27944969
162signal transduction involved in cell cycle checkpoint (GO:0072395)2.26561306
163barbed-end actin filament capping (GO:0051016)2.26520646
164translational termination (GO:0006415)2.25090539
165telomere maintenance via recombination (GO:0000722)2.24443556
166T cell apoptotic process (GO:0070231)2.23696661
167negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.23307736
168protoporphyrinogen IX metabolic process (GO:0046501)10.1614982

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.89312558
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.89120361
3FOXM1_23109430_ChIP-Seq_U2OS_Human2.54972831
4* MYC_18555785_ChIP-Seq_MESCs_Mouse2.42122737
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37926715
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.31321334
7GATA1_22025678_ChIP-Seq_K562_Human2.16271083
8MYC_22102868_ChIP-Seq_BL_Human2.10077243
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.06383900
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05556947
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.05181461
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02612103
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94132436
14* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.89429930
15ETS1_20019798_ChIP-Seq_JURKAT_Human1.87676732
16EST1_17652178_ChIP-ChIP_JURKAT_Human1.86367379
17E2F4_17652178_ChIP-ChIP_JURKAT_Human1.84236223
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84183404
19TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81528336
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.79142907
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78212103
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76084728
23GATA1_19941826_ChIP-Seq_K562_Human1.75952183
24RACK7_27058665_Chip-Seq_MCF-7_Human1.75220681
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73304979
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72865443
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71666011
28VDR_21846776_ChIP-Seq_THP-1_Human1.71662337
29XRN2_22483619_ChIP-Seq_HELA_Human1.66973092
30* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.66688213
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65736786
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63748265
33GATA1_19941827_ChIP-Seq_MEL_Mouse1.60854999
34KDM2B_26808549_Chip-Seq_DND41_Human1.59485208
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58975353
36SCL_19346495_ChIP-Seq_HPC-7_Human1.58683921
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.58602452
38* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58103242
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.56936905
40CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55056896
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54725166
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51871051
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51574186
44* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.49799178
45TCF7_22412390_ChIP-Seq_EML_Mouse1.49563529
46* VDR_23849224_ChIP-Seq_CD4+_Human1.48765503
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.47276056
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46196126
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46000969
50PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44528560
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44514976
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43960257
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43932060
54ZNF263_19887448_ChIP-Seq_K562_Human1.38539570
55* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37867194
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37400645
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35942980
58DCP1A_22483619_ChIP-Seq_HELA_Human1.35132613
59HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.35086439
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.34872831
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34619466
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.33768079
63FOXP3_21729870_ChIP-Seq_TREG_Human1.33295028
64SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33227582
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32477283
66MAF_26560356_Chip-Seq_TH1_Human1.31641327
67CIITA_25753668_ChIP-Seq_RAJI_Human1.29732897
68* GABP_19822575_ChIP-Seq_HepG2_Human1.29130216
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28338964
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27473103
71KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.27182683
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25683915
73* NCOR1_26117541_ChIP-Seq_K562_Human1.25492248
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23099793
75ELF1_20517297_ChIP-Seq_JURKAT_Human1.20783337
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20475455
77* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20216764
78NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19265362
79ATF3_27146783_Chip-Seq_COLON_Human1.18836491
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.18200583
81* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16923454
82BCOR_27268052_Chip-Seq_Bcells_Human1.16887371
83RXR_22158963_ChIP-Seq_LIVER_Mouse1.16577276
84SMC4_20622854_ChIP-Seq_HELA_Human1.15938137
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15817824
86* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15591967
87SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15574709
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14746011
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14200952
90KDM5A_27292631_Chip-Seq_BREAST_Human1.14112228
91MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14061239
92* VDR_24763502_ChIP-Seq_THP-1_Human1.14022949
93CTCF_26484167_Chip-Seq_Bcells_Mouse1.13771969
94* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13604663
95BCL6_27268052_Chip-Seq_Bcells_Human1.13282969
96IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13280098
97KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12724140
98* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12371090
99E2F1_21310950_ChIP-Seq_MCF-7_Human1.12237383
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11904128
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11876600
102* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11504376
103SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10191624
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10168040
105IRF8_22096565_ChIP-ChIP_GC-B_Human1.10084708
106RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09837627
107CLOCK_20551151_ChIP-Seq_293T_Human1.09726009
108ELK3_25401928_ChIP-Seq_HUVEC_Human1.08518917
109* TFEB_21752829_ChIP-Seq_HELA_Human1.08494172
110UTX_26944678_Chip-Seq_JUKART_Human1.08192083
111* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08089790
112* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07863090
113PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07748957
114MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07555418
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07270492
116CTCF_21964334_Chip-Seq_Bcells_Human1.05657828
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05280242
118GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04747442
119EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04237096
120P68_20966046_ChIP-Seq_HELA_Human1.04042991
121TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03341790
122KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02959965
123* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02494729
124MAF_26560356_Chip-Seq_TH2_Human1.02085453
125THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01914194
126E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01896136
127RUNX1_22412390_ChIP-Seq_EML_Mouse1.01837335
128EGR1_19374776_ChIP-ChIP_THP-1_Human1.01674289
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01592255
130* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01061924
131* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00731196
132STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00013986
133MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99813217
134* LXR_22292898_ChIP-Seq_THP-1_Human0.99639798
135AR_21909140_ChIP-Seq_LNCAP_Human0.99118013
136BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97962612
137GATA2_19941826_ChIP-Seq_K562_Human0.97774471

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo6.86014140
2MP0004147_increased_porphyrin_level5.16422953
3MP0005451_abnormal_body_composition4.65404524
4MP0005083_abnormal_biliary_tract3.18979083
5MP0003806_abnormal_nucleotide_metabolis3.15982220
6MP0000749_muscle_degeneration2.50710497
7MP0002139_abnormal_hepatobiliary_system2.30441195
8MP0003646_muscle_fatigue2.28594610
9MP0003111_abnormal_nucleus_morphology2.18672296
10MP0004185_abnormal_adipocyte_glucose2.17785344
11MP0006036_abnormal_mitochondrial_physio2.15721293
12MP0003191_abnormal_cellular_cholesterol2.14940729
13MP0002837_dystrophic_cardiac_calcinosis2.12200657
14MP0000733_abnormal_muscle_development2.03019245
15MP0003186_abnormal_redox_activity1.95510332
16MP0005058_abnormal_lysosome_morphology1.88843224
17MP0005397_hematopoietic_system_phenotyp1.88811069
18MP0001545_abnormal_hematopoietic_system1.88811069
19MP0004510_myositis1.88086801
20MP0010094_abnormal_chromosome_stability1.81422070
21MP0003077_abnormal_cell_cycle1.78757815
22MP0004957_abnormal_blastocyst_morpholog1.76211417
23MP0000685_abnormal_immune_system1.74415674
24MP0003693_abnormal_embryo_hatching1.74164862
25MP0009840_abnormal_foam_cell1.68174315
26MP0000003_abnormal_adipose_tissue1.67676726
27MP0002269_muscular_atrophy1.58786021
28MP0005375_adipose_tissue_phenotype1.55159511
29MP0005620_abnormal_muscle_contractility1.52153667
30MP0000747_muscle_weakness1.52035787
31MP0003705_abnormal_hypodermis_morpholog1.42903896
32MP0008775_abnormal_heart_ventricle1.42550493
33MP0003283_abnormal_digestive_organ1.42523972
34MP0000013_abnormal_adipose_tissue1.39187699
35MP0009333_abnormal_splenocyte_physiolog1.38623069
36MP0005636_abnormal_mineral_homeostasis1.36110172
37MP0000751_myopathy1.34213007
38MP0009278_abnormal_bone_marrow1.33755783
39MP0002822_catalepsy1.33643819
40MP0005330_cardiomyopathy1.33163517
41MP0004087_abnormal_muscle_fiber1.32875837
42MP0000750_abnormal_muscle_regeneration1.31629355
43MP0006138_congestive_heart_failure1.31304687
44MP0008260_abnormal_autophagy1.30661083
45MP0002398_abnormal_bone_marrow1.30236265
46MP0010307_abnormal_tumor_latency1.30157930
47MP0004084_abnormal_cardiac_muscle1.28843525
48MP0010352_gastrointestinal_tract_polyps1.23689958
49MP0004858_abnormal_nervous_system1.22729226
50MP0000759_abnormal_skeletal_muscle1.21578033
51MP0002722_abnormal_immune_system1.20118283
52MP0000689_abnormal_spleen_morphology1.19655358
53MP0001661_extended_life_span1.18215791
54MP0002396_abnormal_hematopoietic_system1.17514139
55MP0005670_abnormal_white_adipose1.16523900
56MP0000609_abnormal_liver_physiology1.14845775
57MP0005076_abnormal_cell_differentiation1.14685721
58MP0004145_abnormal_muscle_electrophysio1.14280074
59MP0001730_embryonic_growth_arrest1.13412120
60MP0002106_abnormal_muscle_physiology1.10689632
61MP0008007_abnormal_cellular_replicative1.08787425
62MP0003763_abnormal_thymus_physiology1.08167458
63MP0002877_abnormal_melanocyte_morpholog1.08091678
64MP0005671_abnormal_response_to1.07802848
65MP0002132_abnormal_respiratory_system1.06409875
66MP0002429_abnormal_blood_cell1.06221760
67MP0003045_fibrosis1.05531432
68MP0004036_abnormal_muscle_relaxation1.04772163
69MP0004233_abnormal_muscle_weight1.02431435
70MP0009643_abnormal_urine_homeostasis1.02311426
71MP0005387_immune_system_phenotype1.01966919
72MP0001790_abnormal_immune_system1.01966919
73MP0000490_abnormal_crypts_of1.01748372
74MP0000358_abnormal_cell_content/1.01339185
75MP0002019_abnormal_tumor_incidence1.01330442
76MP0005501_abnormal_skin_physiology1.00952072
77MP0000350_abnormal_cell_proliferation1.00438882
78MP0000313_abnormal_cell_death0.98064819
79MP0002108_abnormal_muscle_morphology0.97197329
80MP0005319_abnormal_enzyme/_coenzyme0.96855740
81MP0000598_abnormal_liver_morphology0.96071632
82MP0003566_abnormal_cell_adhesion0.95508304
83MP0002971_abnormal_brown_adipose0.94937719
84MP0003300_gastrointestinal_ulcer0.93453163
85MP0001835_abnormal_antigen_presentation0.90831455
86MP0001853_heart_inflammation0.90458145
87MP0000703_abnormal_thymus_morphology0.90039085
88MP0000343_altered_response_to0.89818484
89MP0005266_abnormal_metabolism0.89799422
90MP0006035_abnormal_mitochondrial_morpho0.88835327
91MP0008875_abnormal_xenobiotic_pharmacok0.88535534
92MP0010630_abnormal_cardiac_muscle0.88474552
93MP0004808_abnormal_hematopoietic_stem0.86588932
94MP0002138_abnormal_hepatobiliary_system0.85211979
95MP0002405_respiratory_system_inflammati0.84029482
96MP0005464_abnormal_platelet_physiology0.83786487
97MP0004130_abnormal_muscle_cell0.83657217
98MP0002332_abnormal_exercise_endurance0.82559735
99MP0004043_abnormal_pH_regulation0.81145403
100MP0006054_spinal_hemorrhage0.81056112
101MP0001873_stomach_inflammation0.81006636
102MP0004215_abnormal_myocardial_fiber0.80492973
103MP0005666_abnormal_adipose_tissue0.80324095
104* MP0002080_prenatal_lethality0.79837565
105MP0005365_abnormal_bile_salt0.79760834
106MP0003221_abnormal_cardiomyocyte_apopto0.79698318
107MP0000858_altered_metastatic_potential0.79613815
108MP0005584_abnormal_enzyme/coenzyme_acti0.79576625
109MP0000678_abnormal_parathyroid_gland0.79188426
110MP0008058_abnormal_DNA_repair0.78290467
111MP0009931_abnormal_skin_appearance0.77969084
112MP0005369_muscle_phenotype0.77951019
113MP0000716_abnormal_immune_system0.76568302
114MP0001544_abnormal_cardiovascular_syste0.76013448
115MP0005385_cardiovascular_system_phenoty0.76013448
116MP0003436_decreased_susceptibility_to0.75911254
117MP0002972_abnormal_cardiac_muscle0.75703669
118MP0005085_abnormal_gallbladder_physiolo0.75569343
119MP0008872_abnormal_physiological_respon0.75206475
120MP0005025_abnormal_response_to0.74266683
121MP0003453_abnormal_keratinocyte_physiol0.72663496
122MP0003075_altered_response_to0.72070092
123MP0003303_peritoneal_inflammation0.69027167
124MP0002127_abnormal_cardiovascular_syste0.67026159
125MP0005165_increased_susceptibility_to0.66763387
126MP0002970_abnormal_white_adipose0.66392173
127MP0003828_pulmonary_edema0.63512368
128MP0003950_abnormal_plasma_membrane0.56175616
129MP0001727_abnormal_embryo_implantation0.55631296
130MP0008874_decreased_physiological_sensi0.53998607
131MP0003786_premature_aging0.53968973
132MP0005166_decreased_susceptibility_to0.53064009
133MP0009672_abnormal_birth_weight0.52223324
134MP0002060_abnormal_skin_morphology0.49401626
135MP0001849_ear_inflammation0.49191426
136MP0001348_abnormal_lacrimal_gland0.49061899

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)8.25456201
2Poikilocytosis (HP:0004447)7.01385093
3Reticulocytosis (HP:0001923)6.16731932
4Cholelithiasis (HP:0001081)5.16508566
5Abnormal gallbladder morphology (HP:0012437)4.77008977
6Acanthocytosis (HP:0001927)4.76631886
7Hyperbilirubinemia (HP:0002904)4.27856401
8Paralysis (HP:0003470)4.27575773
9Abnormality of reticulocytes (HP:0004312)4.23982026
10Abnormality of skeletal muscle fiber size (HP:0012084)4.11155292
11Diaphragmatic weakness (HP:0009113)4.04666339
12Neck muscle weakness (HP:0000467)3.88705451
13Exercise-induced muscle cramps (HP:0003710)3.61514301
14Increased variability in muscle fiber diameter (HP:0003557)3.50326932
15Abnormal number of erythroid precursors (HP:0012131)3.48444476
16Myoglobinuria (HP:0002913)3.44994432
17Rhabdomyolysis (HP:0003201)3.39612865
18Distal lower limb amyotrophy (HP:0008944)3.35526344
19Abnormality of the gallbladder (HP:0005264)3.32346710
20Abnormality of cells of the erythroid lineage (HP:0012130)3.13175302
21Increased serum ferritin (HP:0003281)3.11782532
22Abnormal gallbladder physiology (HP:0012438)3.11265061
23Cholecystitis (HP:0001082)3.11265061
24Hypochromic microcytic anemia (HP:0004840)3.02630324
25Abnormality of the calf musculature (HP:0001430)2.97033370
26Calcaneovalgus deformity (HP:0001848)2.93485324
27Abnormality of iron homeostasis (HP:0011031)2.90036275
28Exercise-induced myalgia (HP:0003738)2.88373711
29Muscle fiber inclusion bodies (HP:0100299)2.82106088
30Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.75816853
31Rimmed vacuoles (HP:0003805)2.69650604
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.66980825
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.66980825
34Abnormality of transition element cation homeostasis (HP:0011030)2.66053115
35Mildly elevated creatine phosphokinase (HP:0008180)2.59872332
36Hepatic necrosis (HP:0002605)2.56626990
37Deformed tarsal bones (HP:0008119)2.55261818
38Bulbar palsy (HP:0001283)2.52380881
39Cutaneous photosensitivity (HP:0000992)2.48798266
40Nemaline bodies (HP:0003798)2.47530372
41Spinal rigidity (HP:0003306)2.46580009
42Osteomalacia (HP:0002749)2.46452389
43Frequent falls (HP:0002359)2.46417517
44Polycythemia (HP:0001901)2.42969029
45Achilles tendon contracture (HP:0001771)2.40971941
46Microcytic anemia (HP:0001935)2.39215252
47Increased connective tissue (HP:0009025)2.37263282
48Multiple enchondromatosis (HP:0005701)2.36371186
49Ileus (HP:0002595)2.33952864
50Petechiae (HP:0000967)2.32436462
51Fatigue (HP:0012378)2.30925768
52Hypoglycemic coma (HP:0001325)2.30843669
53Hepatocellular necrosis (HP:0001404)2.30170636
54Ventricular tachycardia (HP:0004756)2.29331365
55Generalized muscle weakness (HP:0003324)2.26206640
56Malignant hyperthermia (HP:0002047)2.25908402
57Foot dorsiflexor weakness (HP:0009027)2.24293184
58Birth length less than 3rd percentile (HP:0003561)2.24140934
59Progressive muscle weakness (HP:0003323)2.23769106
60Lower limb amyotrophy (HP:0007210)2.23577798
61Cerebral palsy (HP:0100021)2.20957121
62Muscle fiber splitting (HP:0003555)2.19393815
63Slender build (HP:0001533)2.19339161
64Type 1 muscle fiber predominance (HP:0003803)2.18985279
65EMG: neuropathic changes (HP:0003445)2.18936952
66Exercise intolerance (HP:0003546)2.18872715
67Abnormality of the foot musculature (HP:0001436)2.17254568
68Ulnar deviation of the wrist (HP:0003049)2.14188604
69Hypochromic anemia (HP:0001931)2.13207024
70Abnormality of the Achilles tendon (HP:0005109)2.12067699
71Trismus (HP:0000211)2.11985796
72Increased muscle lipid content (HP:0009058)2.11797141
73Limb-girdle muscle atrophy (HP:0003797)2.08500082
74Muscle stiffness (HP:0003552)2.08062867
75Abnormality of fatty-acid metabolism (HP:0004359)2.07781137
76Distal arthrogryposis (HP:0005684)2.06934092
77Pustule (HP:0200039)2.06834911
78Myopathic facies (HP:0002058)2.05867922
79Myotonia (HP:0002486)2.05253539
80Urticaria (HP:0001025)2.04903282
81Hyporeflexia of lower limbs (HP:0002600)2.03986376
82Nausea (HP:0002018)2.03965762
83EMG: myopathic abnormalities (HP:0003458)2.03057808
84Difficulty climbing stairs (HP:0003551)2.00880488
85Palpitations (HP:0001962)2.00627184
86Bundle branch block (HP:0011710)1.99717770
87Abnormality of glycolysis (HP:0004366)1.99388110
88Scapular winging (HP:0003691)1.99355123
89Late onset (HP:0003584)1.97305929
90Hyponatremia (HP:0002902)1.97141104
91Easy fatigability (HP:0003388)1.95204470
92Abnormal mitochondria in muscle tissue (HP:0008316)1.91316866
93Generalized amyotrophy (HP:0003700)1.90501470
94Abnormality of the calcaneus (HP:0008364)1.90492685
95Generalized hyperpigmentation (HP:0007440)1.88869437
96Dicarboxylic aciduria (HP:0003215)1.86100174
97Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86100174
98Sudden death (HP:0001699)1.85517062
99Increased serum lactate (HP:0002151)1.85481583
100Ragged-red muscle fibers (HP:0003200)1.83594981
101Weak cry (HP:0001612)1.82484033
102Axonal loss (HP:0003447)1.82093699
103Abnormality of the left ventricular outflow tract (HP:0011103)1.82077539
104Subaortic stenosis (HP:0001682)1.82077539
105Progressive external ophthalmoplegia (HP:0000590)1.81981947
106Metabolic acidosis (HP:0001942)1.81412356
107Reduced subcutaneous adipose tissue (HP:0003758)1.81297615
108Insomnia (HP:0100785)1.80831698
109Lipoatrophy (HP:0100578)1.79922957
110Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78427560
111Increased intramyocellular lipid droplets (HP:0012240)1.77930334
112Vertebral compression fractures (HP:0002953)1.77700992
113Hypertensive crisis (HP:0100735)1.77277044
114Pathologic fracture (HP:0002756)1.76551388
115Stridor (HP:0010307)1.75494084
116Areflexia of lower limbs (HP:0002522)1.74231640
117Asymmetric septal hypertrophy (HP:0001670)1.72653158
118Respiratory insufficiency due to muscle weakness (HP:0002747)1.70505179
119Hyperammonemia (HP:0001987)1.70326402
120Congenital hip dislocation (HP:0001374)1.69937172
121Calf muscle hypertrophy (HP:0008981)1.69840785
122Muscle hypertrophy of the lower extremities (HP:0008968)1.69738306
123Mitochondrial inheritance (HP:0001427)1.69588863
124Lactic acidosis (HP:0003128)1.69437188
125Difficulty running (HP:0009046)1.69271968
126Absent phalangeal crease (HP:0006109)1.69243851
127Round ear (HP:0100830)1.68951583
128Basal cell carcinoma (HP:0002671)1.68936558
129Cerebral hypomyelination (HP:0006808)1.68922875
130Fetal akinesia sequence (HP:0001989)1.68552588
131Abnormal atrioventricular conduction (HP:0005150)1.67458011
132Dilated cardiomyopathy (HP:0001644)1.67434803
133Muscle fiber atrophy (HP:0100295)1.65983899
134Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.65969253
135Respiratory failure (HP:0002878)1.65277342
136Increased CSF lactate (HP:0002490)1.65024781
137Papilloma (HP:0012740)1.64051505
138Verrucae (HP:0200043)1.64051505
139Increased serum pyruvate (HP:0003542)1.63505937
140Acute necrotizing encephalopathy (HP:0006965)1.63054594
141Centrally nucleated skeletal muscle fibers (HP:0003687)1.62468442
142Distal lower limb muscle weakness (HP:0009053)1.61246612
143Gowers sign (HP:0003391)1.60418469
144Muscular dystrophy (HP:0003560)1.52222394
145Waddling gait (HP:0002515)1.50872132
146Neoplasm of head and neck (HP:0012288)1.49649799
147Esophageal neoplasm (HP:0100751)1.49649799
148Abnormal finger flexion creases (HP:0006143)1.49434095
149Shoulder girdle muscle weakness (HP:0003547)1.47989977

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.82491928
2PHKG13.33786934
3PHKG23.33786934
4NME23.16808877
5PRPF4B3.09162078
6BCKDK2.63085766
7TLK12.49771282
8TRIB32.41463850
9NEK12.38589769
10MAP3K112.24206431
11PKN22.17470123
12SMG12.10461692
13TESK22.08738828
14BUB12.07711409
15TTN2.04960536
16MAP4K11.98906763
17ICK1.97422117
18STK101.96258326
19FLT31.94766637
20CDC71.90171734
21EEF2K1.87999027
22TESK11.86857894
23KDR1.84921515
24MAPKAPK31.82963657
25VRK21.82423424
26CDK121.80325992
27PDK31.70414584
28PDK41.70414584
29STK41.69602104
30ERN11.67767182
31CCNB11.57693636
32MAPK121.54989727
33MAP3K101.50237846
34MAP2K31.45087872
35PIM21.42744938
36TSSK61.40967825
37BRSK11.40756779
38OBSCN1.36741539
39MAP3K81.36076773
40LRRK21.35686418
41ARAF1.35070677
42RPS6KB21.26342059
43NEK21.26265453
44ZAK1.21585009
45SCYL21.18118557
46PIK3CG1.17296231
47MAPK111.16963760
48GRK61.06800066
49TYK21.05307037
50PIK3CA1.00808974
51ZAP701.00072264
52TBK10.96469480
53PAK40.96118064
54WEE10.96014344
55MOS0.89729945
56VRK10.87162394
57LMTK20.86574070
58DYRK30.85738788
59PASK0.85248073
60PIM10.84640403
61MAP3K10.84106292
62TRPM70.83864367
63EPHA20.82985288
64AURKA0.82755010
65TAOK20.81903871
66AURKB0.81847539
67MAP2K20.81559897
68MST1R0.80662531
69DAPK30.79264138
70LIMK10.75890026
71CDK40.73854370
72MAP3K130.71728725
73RIPK10.69862841
74NME10.69434507
75MTOR0.69370262
76MAP2K60.69145988
77RPS6KA50.67928913
78ILK0.67492298
79STK160.67336016
80KSR20.67126608
81PLK10.67012760
82SYK0.66630539
83DYRK1B0.65848444
84PDK20.65577722
85PDPK10.63823145
86IKBKB0.62619679
87MUSK0.62108639
88MAPKAPK20.59390515
89RPS6KL10.58745408
90STK240.57804939
91DMPK0.56721960
92JAK30.56138043
93CDK80.55742243
94RPS6KA40.55616445
95NEK90.54052458
96MST40.53667761
97BRSK20.53608917
98MAP3K70.53253731
99SIK10.52950146
100CDK70.52561305
101CAMK2G0.51085074
102TAOK10.50336912
103MYLK0.50204648
104HIPK20.49468063
105MAP3K30.47842446
106PRKG20.47475570
107MET0.47084233
108DAPK10.46652318
109IKBKE0.46514337
110PAK10.45479402
111TIE10.45360187
112BMX0.44383017
113ABL20.44318628
114EPHB10.43646390
115CDC42BPA0.42349475
116MAPK40.41463042
117ATR0.40112565
118BRAF0.39233658
119CHEK10.39037359
120AKT20.38883386
121RPS6KA60.38323324
122SIK30.37927885
123BTK0.37434966
124IRAK30.36994079
125PINK10.36785522
126IRAK20.36651474
127MAP2K10.36627651
128JAK20.36383457
129PRKD20.36173926
130CSNK2A10.36090341
131CAMK40.36059826
132CDK60.35961677
133TTK0.35037574
134RPS6KC10.34423376
135MARK20.32371059
136PDK10.32155109
137MAPKAPK50.31446768
138PRKD30.31065434
139MARK30.30766378
140RAF10.30746052
141RPS6KA20.29097386
142CHEK20.28324045

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008604.23785226
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.55255565
3DNA replication_Homo sapiens_hsa030303.18701357
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.91111717
5Sulfur relay system_Homo sapiens_hsa041222.86008572
6Proteasome_Homo sapiens_hsa030502.58625845
7Systemic lupus erythematosus_Homo sapiens_hsa053222.41720386
8Carbon metabolism_Homo sapiens_hsa012002.09772485
9Mismatch repair_Homo sapiens_hsa034302.09280553
10Ribosome_Homo sapiens_hsa030102.03326707
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.00773594
12Biosynthesis of amino acids_Homo sapiens_hsa012301.93319728
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85128829
14Dilated cardiomyopathy_Homo sapiens_hsa054141.82053408
15Pyruvate metabolism_Homo sapiens_hsa006201.81594353
16One carbon pool by folate_Homo sapiens_hsa006701.74400479
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72030290
18Insulin signaling pathway_Homo sapiens_hsa049101.70510798
19Base excision repair_Homo sapiens_hsa034101.70491503
20Parkinsons disease_Homo sapiens_hsa050121.68540414
21Sulfur metabolism_Homo sapiens_hsa009201.65996458
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.64954063
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.55538227
24Pentose phosphate pathway_Homo sapiens_hsa000301.42690712
25Oxidative phosphorylation_Homo sapiens_hsa001901.42301317
26Fatty acid degradation_Homo sapiens_hsa000711.41989468
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41820653
28Vitamin B6 metabolism_Homo sapiens_hsa007501.40533983
29Selenocompound metabolism_Homo sapiens_hsa004501.36768286
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36310820
31AMPK signaling pathway_Homo sapiens_hsa041521.35899859
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34396590
33Cell cycle_Homo sapiens_hsa041101.32885002
34Folate biosynthesis_Homo sapiens_hsa007901.32566706
35Propanoate metabolism_Homo sapiens_hsa006401.32327268
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30852755
37Glucagon signaling pathway_Homo sapiens_hsa049221.30328246
38Spliceosome_Homo sapiens_hsa030401.25932304
39Homologous recombination_Homo sapiens_hsa034401.22419629
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.21402300
41Fructose and mannose metabolism_Homo sapiens_hsa000511.17875464
42Pyrimidine metabolism_Homo sapiens_hsa002401.17800053
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.17676808
44Antigen processing and presentation_Homo sapiens_hsa046121.09689368
45RNA transport_Homo sapiens_hsa030131.09647000
46Non-small cell lung cancer_Homo sapiens_hsa052231.02495607
47Chronic myeloid leukemia_Homo sapiens_hsa052201.00080373
48* Nucleotide excision repair_Homo sapiens_hsa034200.98285632
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97492829
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97276749
51Viral carcinogenesis_Homo sapiens_hsa052030.97171399
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96117484
53VEGF signaling pathway_Homo sapiens_hsa043700.93975573
54Huntingtons disease_Homo sapiens_hsa050160.92526465
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86207070
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85377037
57RNA polymerase_Homo sapiens_hsa030200.83639895
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83154928
59Phenylalanine metabolism_Homo sapiens_hsa003600.82057147
60Prion diseases_Homo sapiens_hsa050200.81984744
61Bladder cancer_Homo sapiens_hsa052190.79937978
62Galactose metabolism_Homo sapiens_hsa000520.79548637
63Alcoholism_Homo sapiens_hsa050340.79441101
64* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78636963
65Tryptophan metabolism_Homo sapiens_hsa003800.76718184
66Pancreatic cancer_Homo sapiens_hsa052120.76698337
67Legionellosis_Homo sapiens_hsa051340.76086727
68Fatty acid metabolism_Homo sapiens_hsa012120.75989818
69Circadian rhythm_Homo sapiens_hsa047100.75468390
70p53 signaling pathway_Homo sapiens_hsa041150.75036215
71Cardiac muscle contraction_Homo sapiens_hsa042600.71415820
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71377526
73Primary immunodeficiency_Homo sapiens_hsa053400.71281743
74Alzheimers disease_Homo sapiens_hsa050100.70335603
75ABC transporters_Homo sapiens_hsa020100.69950896
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69683551
77Glutathione metabolism_Homo sapiens_hsa004800.69659189
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68765980
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.68253664
80Hematopoietic cell lineage_Homo sapiens_hsa046400.67576914
81Glioma_Homo sapiens_hsa052140.65238245
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.64422101
83Apoptosis_Homo sapiens_hsa042100.63978256
84mTOR signaling pathway_Homo sapiens_hsa041500.61281841
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.60372366
86Fat digestion and absorption_Homo sapiens_hsa049750.60161160
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56760379
88Protein export_Homo sapiens_hsa030600.56365045
89Arginine and proline metabolism_Homo sapiens_hsa003300.56053940
90PPAR signaling pathway_Homo sapiens_hsa033200.55465329
91mRNA surveillance pathway_Homo sapiens_hsa030150.54568997
92Peroxisome_Homo sapiens_hsa041460.54193353
93beta-Alanine metabolism_Homo sapiens_hsa004100.53745800
94Measles_Homo sapiens_hsa051620.53317028
95Arginine biosynthesis_Homo sapiens_hsa002200.53016986
96Epstein-Barr virus infection_Homo sapiens_hsa051690.52116198
97RNA degradation_Homo sapiens_hsa030180.51805803
98Lysine degradation_Homo sapiens_hsa003100.51734843
99Metabolic pathways_Homo sapiens_hsa011000.51329466
100Renal cell carcinoma_Homo sapiens_hsa052110.51081298
101N-Glycan biosynthesis_Homo sapiens_hsa005100.48868572
102GnRH signaling pathway_Homo sapiens_hsa049120.48568296
103Tyrosine metabolism_Homo sapiens_hsa003500.47233277
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46691530
105B cell receptor signaling pathway_Homo sapiens_hsa046620.46574001
106Other glycan degradation_Homo sapiens_hsa005110.45585870
107Thyroid cancer_Homo sapiens_hsa052160.45345145
108Purine metabolism_Homo sapiens_hsa002300.45096911
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.43414906
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41946996
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41123156
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38935466
113Oxytocin signaling pathway_Homo sapiens_hsa049210.38739823
114Malaria_Homo sapiens_hsa051440.38115505
115HIF-1 signaling pathway_Homo sapiens_hsa040660.37855313
116Insulin resistance_Homo sapiens_hsa049310.37637538
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37121626
118Herpes simplex infection_Homo sapiens_hsa051680.36170806
119Fatty acid elongation_Homo sapiens_hsa000620.35615396
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35522163
121Starch and sucrose metabolism_Homo sapiens_hsa005000.35395435
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.34090262
123Hepatitis B_Homo sapiens_hsa051610.33867924
124Fanconi anemia pathway_Homo sapiens_hsa034600.32992533
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.32732614
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32714012
127Vibrio cholerae infection_Homo sapiens_hsa051100.32571732
128Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31032969
129Shigellosis_Homo sapiens_hsa051310.30995001
130Acute myeloid leukemia_Homo sapiens_hsa052210.30309869
131Viral myocarditis_Homo sapiens_hsa054160.28914296
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28902050
133HTLV-I infection_Homo sapiens_hsa051660.27993124
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27721682
135Long-term potentiation_Homo sapiens_hsa047200.27196431

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