RAD23B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.89184687
2COPI coating of Golgi vesicle (GO:0048205)4.89184687
3nuclear pore complex assembly (GO:0051292)4.76033760
4nuclear pore organization (GO:0006999)4.59993414
5folic acid-containing compound biosynthetic process (GO:0009396)4.25173715
6pre-miRNA processing (GO:0031054)4.20523502
7heterochromatin organization (GO:0070828)4.02862051
8desmosome organization (GO:0002934)3.99710631
9regulation of translational termination (GO:0006449)3.87898787
10regulation of translational fidelity (GO:0006450)3.84407340
11regulation of hippo signaling (GO:0035330)3.69244766
12peptidyl-lysine dimethylation (GO:0018027)3.59306821
13cell-substrate junction assembly (GO:0007044)3.52786623
14planar cell polarity pathway involved in neural tube closure (GO:0090179)3.52585069
15NLS-bearing protein import into nucleus (GO:0006607)3.52519185
16hippo signaling (GO:0035329)3.46815909
17maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.46058276
18mitotic sister chromatid cohesion (GO:0007064)3.43425415
19regulation of glucose import in response to insulin stimulus (GO:2001273)3.42619700
20regulation of RNA export from nucleus (GO:0046831)3.41075995
21regulation of gene silencing by RNA (GO:0060966)3.39868411
22regulation of posttranscriptional gene silencing (GO:0060147)3.39868411
23regulation of gene silencing by miRNA (GO:0060964)3.39868411
24regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.32771638
25regulation of early endosome to late endosome transport (GO:2000641)3.31970588
26hemidesmosome assembly (GO:0031581)3.31814959
27DNA unwinding involved in DNA replication (GO:0006268)3.30845171
28paraxial mesoderm development (GO:0048339)3.29125321
29protein retention in ER lumen (GO:0006621)3.28757738
30epithelial cell-cell adhesion (GO:0090136)3.25010147
31negative regulation of fibrinolysis (GO:0051918)3.22897415
32retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.22281753
33mRNA stabilization (GO:0048255)3.21414274
34RNA stabilization (GO:0043489)3.21414274
35skin morphogenesis (GO:0043589)3.18609563
36glycine metabolic process (GO:0006544)3.17277978
37polarized epithelial cell differentiation (GO:0030859)3.14263677
38pore complex assembly (GO:0046931)3.13152161
39protein localization to microtubule (GO:0035372)3.12541541
40chaperone-mediated protein complex assembly (GO:0051131)3.11611988
41COPII vesicle coating (GO:0048208)3.11393452
42chromatin assembly (GO:0031497)3.10654222
43histone H2A monoubiquitination (GO:0035518)3.06966333
44cellular protein complex localization (GO:0034629)3.06276072
45establishment of apical/basal cell polarity (GO:0035089)3.02242378
46cell adhesion mediated by integrin (GO:0033627)3.01930304
47positive regulation of SMAD protein import into nucleus (GO:0060391)3.01216376
48vesicle coating (GO:0006901)2.98455657
49regulation of fatty acid beta-oxidation (GO:0031998)2.96595514
50tetrahydrofolate metabolic process (GO:0046653)2.96593509
51adherens junction assembly (GO:0034333)2.96540551
52embryonic process involved in female pregnancy (GO:0060136)2.96058177
53membrane disassembly (GO:0030397)2.95779700
54nuclear envelope disassembly (GO:0051081)2.95779700
55mitotic nuclear envelope disassembly (GO:0007077)2.95752112
56protein localization to kinetochore (GO:0034501)2.95731706
57protein complex localization (GO:0031503)2.95157340
58negative regulation of histone methylation (GO:0031061)2.93606995
59spliceosomal tri-snRNP complex assembly (GO:0000244)2.93102321
60maternal placenta development (GO:0001893)2.92794121
61negative regulation of fatty acid transport (GO:2000192)2.90115439
62cytoplasmic mRNA processing body assembly (GO:0033962)2.89150014
63dicarboxylic acid biosynthetic process (GO:0043650)2.86060079
64regulation of cholesterol homeostasis (GO:2000188)2.85095544
65negative regulation of cell size (GO:0045792)2.84748166
66glucocorticoid receptor signaling pathway (GO:0042921)2.84375011
67notochord development (GO:0030903)2.83935004
68regulation of sister chromatid cohesion (GO:0007063)2.83638049
69regulation of nucleobase-containing compound transport (GO:0032239)2.83228017
70activation of Rac GTPase activity (GO:0032863)2.83185042
71alpha-linolenic acid metabolic process (GO:0036109)2.81118802
72basement membrane organization (GO:0071711)2.79868421
73DNA replication-dependent nucleosome organization (GO:0034723)2.79276470
74DNA replication-dependent nucleosome assembly (GO:0006335)2.79276470
75anterior/posterior axis specification, embryo (GO:0008595)2.78244799
76negative regulation of DNA repair (GO:0045738)2.77574077
77midgut development (GO:0007494)2.77426111
78protein localization to endosome (GO:0036010)2.77052366
79regulation of mammary gland epithelial cell proliferation (GO:0033599)2.76975121
80proline biosynthetic process (GO:0006561)2.76310296
81sister chromatid segregation (GO:0000819)2.75398653
82negative regulation of fatty acid biosynthetic process (GO:0045717)2.74786112
83regulation of SMAD protein import into nucleus (GO:0060390)2.72840466
84one-carbon metabolic process (GO:0006730)2.70480071
85dosage compensation (GO:0007549)2.70463370
864-hydroxyproline metabolic process (GO:0019471)2.70448211
87bundle of His cell to Purkinje myocyte communication (GO:0086069)2.69571562
88lysine metabolic process (GO:0006553)2.69439535
89lysine catabolic process (GO:0006554)2.69439535
90dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.68473005
91positive regulation of fatty acid beta-oxidation (GO:0032000)2.68348558
92gap junction assembly (GO:0016264)2.68185273
93regulation of histone H3-K9 methylation (GO:0051570)2.68076622
94regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.67205278
95protein export from nucleus (GO:0006611)2.67146369
96urea metabolic process (GO:0019627)2.64668988
97urea cycle (GO:0000050)2.64668988
98cytoskeletal anchoring at plasma membrane (GO:0007016)2.64101747
99cell-substrate adherens junction assembly (GO:0007045)2.62972013
100focal adhesion assembly (GO:0048041)2.62972013
101establishment or maintenance of monopolar cell polarity (GO:0061339)2.62631297
102establishment of monopolar cell polarity (GO:0061162)2.62631297
103serine family amino acid catabolic process (GO:0009071)2.60613476
104regulation of NFAT protein import into nucleus (GO:0051532)2.57452322
105chromosome condensation (GO:0030261)2.56989274
106regulation of fibrinolysis (GO:0051917)2.54929253
107mitotic chromosome condensation (GO:0007076)2.54720708
108gene silencing by RNA (GO:0031047)2.51874093
109DNA duplex unwinding (GO:0032508)2.50385830
110Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.50233547
111cysteine metabolic process (GO:0006534)2.48540869
112regulation of histone H3-K27 methylation (GO:0061085)2.48531469
113epithelial cell differentiation involved in prostate gland development (GO:0060742)2.48271487
114insulin-like growth factor receptor signaling pathway (GO:0048009)2.48158889
115trophectodermal cell differentiation (GO:0001829)2.47965262
116positive regulation of nuclease activity (GO:0032075)2.47870330
117branching involved in mammary gland duct morphogenesis (GO:0060444)2.47451758
118nuclear envelope organization (GO:0006998)2.47295905
119DNA geometric change (GO:0032392)2.47140717
120embryonic eye morphogenesis (GO:0048048)2.44739888
121serine family amino acid metabolic process (GO:0009069)2.44671372
122negative regulation of sterol transport (GO:0032372)2.44027219
123negative regulation of cholesterol transport (GO:0032375)2.44027219
124positive regulation of mitotic sister chromatid separation (GO:1901970)2.43972366
125positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.43972366
126positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.43972366
127ER-nucleus signaling pathway (GO:0006984)2.43585947
128epoxygenase P450 pathway (GO:0019373)2.43004714
129regulation of establishment of planar polarity (GO:0090175)2.42623263
130serine family amino acid biosynthetic process (GO:0009070)2.42025707
131mitotic G1 DNA damage checkpoint (GO:0031571)2.41723188
132mammary gland epithelial cell proliferation (GO:0033598)2.41289392
133plasma membrane repair (GO:0001778)2.41073126
134positive regulation of cellular response to insulin stimulus (GO:1900078)2.40846532
135gastrulation with mouth forming second (GO:0001702)2.40690809
136peptidyl-arginine omega-N-methylation (GO:0035247)2.40480618
137stress fiber assembly (GO:0043149)2.40236568
138regulation of mRNA stability (GO:0043488)2.40195644
139activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.39565224
140endoplasmic reticulum unfolded protein response (GO:0030968)2.39211450
141positive regulation of chromosome segregation (GO:0051984)2.39190955
142regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.38080754
143cellular response to epidermal growth factor stimulus (GO:0071364)2.37808520
144low-density lipoprotein particle clearance (GO:0034383)2.36571373
145embryonic foregut morphogenesis (GO:0048617)2.36340557
146convergent extension (GO:0060026)2.32346510
147embryonic camera-type eye morphogenesis (GO:0048596)2.31877335
148regulation of mitotic spindle organization (GO:0060236)2.31504765
149positive regulation of blood vessel endothelial cell migration (GO:0043536)2.31184437
150protein hydroxylation (GO:0018126)2.30891394
151regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.29181477
152regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.28420144
153regulation of transforming growth factor beta2 production (GO:0032909)2.27688646
154iron ion import (GO:0097286)2.27355566
155negative regulation of protein localization to plasma membrane (GO:1903077)2.25823147
156nucleobase-containing small molecule interconversion (GO:0015949)2.24558967
157regulation of nuclease activity (GO:0032069)2.23034145
158peptidyl-proline hydroxylation (GO:0019511)2.23020238
159positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.21316828
160endodermal cell differentiation (GO:0035987)2.21043467
161positive regulation of protein export from nucleus (GO:0046827)2.20840993
162mitotic cytokinesis (GO:0000281)2.20525546
163G1 DNA damage checkpoint (GO:0044783)2.20476287
164regulation of protein export from nucleus (GO:0046825)2.20432385
165pentose-phosphate shunt (GO:0006098)2.19442987
166positive regulation of endothelial cell apoptotic process (GO:2000353)2.19353408
167cellular response to unfolded protein (GO:0034620)2.19300646

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.55898017
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.47289722
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.72899737
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.57135925
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.49352793
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.10203265
7ZNF263_19887448_ChIP-Seq_K562_Human2.66666291
8CLOCK_20551151_ChIP-Seq_293T_Human2.50275908
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.42747796
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.37846561
11ESR1_15608294_ChIP-ChIP_MCF-7_Human2.37119518
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.34722046
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.28630024
14* MYC_22102868_ChIP-Seq_BL_Human2.27938059
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.25366181
16AR_21909140_ChIP-Seq_LNCAP_Human2.19500672
17* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.16122391
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.10465626
19SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.08035772
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.02087289
21LXR_22158963_ChIP-Seq_LIVER_Mouse2.00919131
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.00030483
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.99032828
24ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.95514094
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.90461048
26* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.87367107
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.85904224
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.84730902
29TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.82387502
30SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.74615130
31STAT3_1855785_ChIP-Seq_MESCs_Mouse1.73891465
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.73084594
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.72353342
34ZFP281_27345836_Chip-Seq_ESCs_Mouse1.71646534
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.70169433
36P300_27058665_Chip-Seq_ZR-75-30cells_Human1.69221796
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.66630840
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66466650
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64644652
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.62943705
41KDM2B_26808549_Chip-Seq_DND41_Human1.62604625
42* ATF3_27146783_Chip-Seq_COLON_Human1.62197692
43* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57068080
44KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56260754
45CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.50616963
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50241591
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49856254
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49223528
49TCF7_22412390_ChIP-Seq_EML_Mouse1.48398218
50SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.48077554
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.48077554
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47984159
53TCF3_18692474_ChIP-Seq_MEFs_Mouse1.47016168
54* E2F1_21310950_ChIP-Seq_MCF-7_Human1.45299392
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44570560
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43349311
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43138378
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43039487
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.41733547
60CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.40334201
61PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39091909
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38517399
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38209342
64* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37810947
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.36686012
66UBF1/2_26484160_Chip-Seq_HMECs_Human1.36250518
67* CHD1_26751641_Chip-Seq_LNCaP_Human1.35155939
68* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33739954
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30667549
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.30648365
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.30646375
72SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30134541
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.29909413
74LXR_22292898_ChIP-Seq_THP-1_Human1.28146574
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27949026
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27499912
77TCF3_18692474_ChIP-Seq_MESCs_Mouse1.26786623
78* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25728659
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25262451
80NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.25166199
81RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24764250
82SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.24639847
83SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24581055
84EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.24274812
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.24145124
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23700441
87RACK7_27058665_Chip-Seq_MCF-7_Human1.22826471
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22549879
89STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21985733
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21434915
91KDM2B_26808549_Chip-Seq_JURKAT_Human1.19928054
92* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19782223
93CREB1_26743006_Chip-Seq_LNCaP_Human1.19219499
94KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19183009
95NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.18821020
96NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.18720425
97POU5F1_16518401_ChIP-PET_MESCs_Mouse1.18562347
98ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18243263
99* NANOG_21062744_ChIP-ChIP_HESCs_Human1.16235171
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16134303
101FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.15590049
102PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15528579
103* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.14728713
104* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.14138365
105KDM2B_26808549_Chip-Seq_K562_Human1.10930615
106* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10225077
107GATA6_25053715_ChIP-Seq_YYC3_Human1.10187909
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10026436
109* RUNX1_27514584_Chip-Seq_MCF-7_Human1.07743915
110* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07424965
111* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05988402
112* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04679112
113* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04141121
114TRIM28_21343339_ChIP-Seq_HEK293_Human1.04066579
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03551146
116* NCOR1_26117541_ChIP-Seq_K562_Human1.03129491
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02961305
118* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02872944
119* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02673618
120SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02546986
121NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02332582
122* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02320481
123TP53_22127205_ChIP-Seq_IMR90_Human1.02293088
124TBX20_22328084_ChIP-Seq_HEART_Mouse1.02071440
125TBX20_22080862_ChIP-Seq_HEART_Mouse1.02071440
126SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01739578
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00557227
128* KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99456693
129* KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99456693
130* KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99456693
131PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98912877
132FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98483628
133SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97960636
134BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97814408
135KDM5A_27292631_Chip-Seq_BREAST_Human0.97413939

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog5.14200058
2MP0010352_gastrointestinal_tract_polyps3.36510842
3MP0010234_abnormal_vibrissa_follicle3.18962889
4MP0002139_abnormal_hepatobiliary_system2.91699966
5MP0005076_abnormal_cell_differentiation2.85861026
6MP0003941_abnormal_skin_development2.62319832
7MP0005360_urolithiasis2.55973100
8MP0005451_abnormal_body_composition2.37484251
9MP0005623_abnormal_meninges_morphology2.31010993
10MP0000537_abnormal_urethra_morphology2.30717806
11MP0008438_abnormal_cutaneous_collagen2.17926991
12MP0005085_abnormal_gallbladder_physiolo2.15182721
13MP0003566_abnormal_cell_adhesion1.96073505
14MP0002877_abnormal_melanocyte_morpholog1.95619253
15MP0001730_embryonic_growth_arrest1.90297376
16MP0004185_abnormal_adipocyte_glucose1.88894114
17MP0005365_abnormal_bile_salt1.88430081
18* MP0004197_abnormal_fetal_growth/weight/1.87839988
19MP0003252_abnormal_bile_duct1.83304475
20MP0010307_abnormal_tumor_latency1.82191940
21MP0003123_paternal_imprinting1.78149866
22MP0002084_abnormal_developmental_patter1.74571094
23MP0005409_darkened_coat_color1.74233531
24MP0003806_abnormal_nucleotide_metabolis1.69741326
25MP0000733_abnormal_muscle_development1.64272763
26MP0005275_abnormal_skin_tensile1.63848892
27MP0010030_abnormal_orbit_morphology1.60920767
28* MP0002086_abnormal_extraembryonic_tissu1.60202822
29MP0004957_abnormal_blastocyst_morpholog1.58304797
30MP0002009_preneoplasia1.58250939
31MP0005380_embryogenesis_phenotype1.56545592
32MP0001672_abnormal_embryogenesis/_devel1.56545592
33MP0001849_ear_inflammation1.55180786
34MP0003950_abnormal_plasma_membrane1.52754400
35MP0002088_abnormal_embryonic_growth/wei1.51380562
36MP0003890_abnormal_embryonic-extraembry1.51189883
37MP0003984_embryonic_growth_retardation1.50400910
38MP0004858_abnormal_nervous_system1.48266882
39MP0001697_abnormal_embryo_size1.46650236
40MP0003119_abnormal_digestive_system1.46638137
41MP0000350_abnormal_cell_proliferation1.45969613
42MP0002085_abnormal_embryonic_tissue1.44753832
43MP0003111_abnormal_nucleus_morphology1.44638596
44MP0003300_gastrointestinal_ulcer1.43842803
45MP0009672_abnormal_birth_weight1.43317306
46MP0004233_abnormal_muscle_weight1.42895957
47MP0005187_abnormal_penis_morphology1.39003140
48MP0003283_abnormal_digestive_organ1.35993387
49MP0000579_abnormal_nail_morphology1.34814261
50MP0003115_abnormal_respiratory_system1.32500252
51MP0005023_abnormal_wound_healing1.30264622
52MP0005083_abnormal_biliary_tract1.28464284
53MP0004272_abnormal_basement_membrane1.27291500
54MP0003567_abnormal_fetal_cardiomyocyte1.27005330
55MP0000762_abnormal_tongue_morphology1.26813983
56MP0000751_myopathy1.25255688
57MP0002697_abnormal_eye_size1.24788092
58MP0003091_abnormal_cell_migration1.24046371
59MP0010329_abnormal_lipoprotein_level1.22094460
60MP0002080_prenatal_lethality1.21360513
61MP0009384_cardiac_valve_regurgitation1.19654634
62MP0005666_abnormal_adipose_tissue1.19142735
63MP0001915_intracranial_hemorrhage1.18919313
64MP0004782_abnormal_surfactant_physiolog1.16937279
65MP0000566_synostosis1.16674698
66MP0003077_abnormal_cell_cycle1.16577830
67MP0003693_abnormal_embryo_hatching1.15427517
68MP0000428_abnormal_craniofacial_morphol1.15037348
69* MP0009053_abnormal_anal_canal1.13617751
70MP0001216_abnormal_epidermal_layer1.13349992
71MP0010094_abnormal_chromosome_stability1.11324019
72MP0000759_abnormal_skeletal_muscle1.10759353
73MP0004264_abnormal_extraembryonic_tissu1.10290597
74MP0005248_abnormal_Harderian_gland1.10176144
75MP0000747_muscle_weakness1.08384793
76MP0001661_extended_life_span1.07523313
77MP0002282_abnormal_trachea_morphology1.04260880
78* MP0009703_decreased_birth_body1.04205300
79MP0000377_abnormal_hair_follicle1.03829267
80MP0000627_abnormal_mammary_gland1.03139163
81MP0002098_abnormal_vibrissa_morphology1.03063171
82MP0002089_abnormal_postnatal_growth/wei1.02356348
83MP0008057_abnormal_DNA_replication1.01886480
84MP0000569_abnormal_digit_pigmentation0.99547233
85MP0003937_abnormal_limbs/digits/tail_de0.99468757
86MP0003385_abnormal_body_wall0.99063540
87MP0000467_abnormal_esophagus_morphology0.98650935
88MP0003191_abnormal_cellular_cholesterol0.97982944
89MP0001958_emphysema0.97749859
90MP0002796_impaired_skin_barrier0.97737973
91MP0002896_abnormal_bone_mineralization0.97454958
92MP0003453_abnormal_keratinocyte_physiol0.94917777
93MP0005375_adipose_tissue_phenotype0.94216322
94MP0000462_abnormal_digestive_system0.94190926
95MP0003935_abnormal_craniofacial_develop0.93823299
96MP0008932_abnormal_embryonic_tissue0.93663250
97MP0004087_abnormal_muscle_fiber0.92924540
98MP0003121_genomic_imprinting0.92064046
99MP0008770_decreased_survivor_rate0.92062467
100MP0001299_abnormal_eye_distance/0.92032447
101MP0002111_abnormal_tail_morphology0.91897802
102MP0009840_abnormal_foam_cell0.91703067
103MP0006138_congestive_heart_failure0.90592657
104MP0010630_abnormal_cardiac_muscle0.89879425
105MP0000767_abnormal_smooth_muscle0.89841623
106MP0005503_abnormal_tendon_morphology0.89684938
107MP0003221_abnormal_cardiomyocyte_apopto0.89316675
108MP0000609_abnormal_liver_physiology0.88581804
109MP0005257_abnormal_intraocular_pressure0.88446220
110MP0009780_abnormal_chondrocyte_physiolo0.87802534
111MP0003315_abnormal_perineum_morphology0.87209719
112MP0002269_muscular_atrophy0.87179315
113* MP0002925_abnormal_cardiovascular_devel0.87041884
114MP0005621_abnormal_cell_physiology0.86184724
115* MP0002092_abnormal_eye_morphology0.85824024
116MP0000534_abnormal_ureter_morphology0.85616839
117MP0000750_abnormal_muscle_regeneration0.85063989
118MP0001881_abnormal_mammary_gland0.83426921
119MP0010678_abnormal_skin_adnexa0.83112680
120MP0006054_spinal_hemorrhage0.83096309
121MP0004130_abnormal_muscle_cell0.82053411
122MP0000516_abnormal_urinary_system0.81556034
123MP0005367_renal/urinary_system_phenotyp0.81556034
124MP0002653_abnormal_ependyma_morphology0.81547072
125MP0001293_anophthalmia0.81247239
126MP0003942_abnormal_urinary_system0.81068151
127MP0001346_abnormal_lacrimal_gland0.79924335
128* MP0000432_abnormal_head_morphology0.79836829
129MP0005501_abnormal_skin_physiology0.79293263
130MP0003861_abnormal_nervous_system0.78389132
131MP0003279_aneurysm0.78330678
132MP0002060_abnormal_skin_morphology0.77732977
133MP0000003_abnormal_adipose_tissue0.77591485
134MP0002108_abnormal_muscle_morphology0.77502179
135MP0008875_abnormal_xenobiotic_pharmacok0.77139135
136MP0008961_abnormal_basal_metabolism0.76545674
137MP0003303_peritoneal_inflammation0.75480736
138MP0000598_abnormal_liver_morphology0.74625072

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.41724379
2Asymmetry of the thorax (HP:0001555)3.41328238
3Deep venous thrombosis (HP:0002625)3.35297662
4Abnormality of the lower motor neuron (HP:0002366)3.13268880
5Shallow orbits (HP:0000586)3.02636933
6Ependymoma (HP:0002888)2.86447337
7Pseudobulbar signs (HP:0002200)2.82592507
8Abnormality of the astrocytes (HP:0100707)2.79316475
9Astrocytoma (HP:0009592)2.79316475
10Abnormality of the Achilles tendon (HP:0005109)2.76797894
11Spastic diplegia (HP:0001264)2.76698734
12Achilles tendon contracture (HP:0001771)2.65461464
13Back pain (HP:0003418)2.65109712
14Premature rupture of membranes (HP:0001788)2.64113200
15Abnormality of monocarboxylic acid metabolism (HP:0010996)2.63709811
16Intrahepatic cholestasis (HP:0001406)2.59084639
17Cerebral aneurysm (HP:0004944)2.53414868
18Subacute progressive viral hepatitis (HP:0006572)2.51841560
19Mitral valve prolapse (HP:0001634)2.47934885
20Osteolytic defects of the phalanges of the hand (HP:0009771)2.47825673
21Osteolytic defects of the hand bones (HP:0009699)2.47825673
22Flat acetabular roof (HP:0003180)2.45739074
23Arterial tortuosity (HP:0005116)2.45318481
24Genu recurvatum (HP:0002816)2.45023159
25Hyperacusis (HP:0010780)2.44853736
26Vascular tortuosity (HP:0004948)2.38001882
27Ankle contracture (HP:0006466)2.37573673
28Spinal rigidity (HP:0003306)2.35313741
29Advanced eruption of teeth (HP:0006288)2.32525654
30Increased connective tissue (HP:0009025)2.31676251
31Renovascular hypertension (HP:0100817)2.31382494
32Vertebral compression fractures (HP:0002953)2.31270583
33Distal lower limb amyotrophy (HP:0008944)2.30583587
34Heterotopia (HP:0002282)2.29561858
35Right ventricular cardiomyopathy (HP:0011663)2.28499283
36Xanthomatosis (HP:0000991)2.27444709
37Hypobetalipoproteinemia (HP:0003563)2.23028776
38Cortical dysplasia (HP:0002539)2.21864592
39Distal upper limb amyotrophy (HP:0007149)2.21772575
40Upper limb amyotrophy (HP:0009129)2.21772575
41Fragile skin (HP:0001030)2.20440091
42Bowel diverticulosis (HP:0005222)2.19904524
43Type 1 muscle fiber predominance (HP:0003803)2.17339340
44Spinal cord lesions (HP:0100561)2.16178735
45Syringomyelia (HP:0003396)2.16178735
46Lymphangioma (HP:0100764)2.15813319
47Natal tooth (HP:0000695)2.15312710
48Insidious onset (HP:0003587)2.15060026
49Termporal pattern (HP:0011008)2.15060026
50Abnormality of oral frenula (HP:0000190)2.14733819
51Renal duplication (HP:0000075)2.13204785
52Hand muscle atrophy (HP:0009130)2.13009026
53Fibroma (HP:0010614)2.11719101
54Biliary tract neoplasm (HP:0100574)2.10726427
55Increased density of long bones (HP:0006392)2.10343353
56Difficulty climbing stairs (HP:0003551)2.09953373
57Ulnar bowing (HP:0003031)2.08258841
58Short nail (HP:0001799)2.08098625
59Atrophic scars (HP:0001075)2.07364318
60Short 4th metacarpal (HP:0010044)2.06565625
61Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.06565625
62Mildly elevated creatine phosphokinase (HP:0008180)2.05920528
63Fibrous tissue neoplasm (HP:0012316)2.05280102
64Enlarged penis (HP:0000040)2.04539418
65Pelvic girdle muscle weakness (HP:0003749)2.04071149
66Deviation of the thumb (HP:0009603)2.03401381
67Hallux valgus (HP:0001822)2.03329268
68Rectal prolapse (HP:0002035)2.02805870
69Disproportionate tall stature (HP:0001519)2.01792982
70Increased nuchal translucency (HP:0010880)2.01728432
71Broad face (HP:0000283)2.01351450
72Deviation of the hallux (HP:0010051)2.01341885
73Sparse lateral eyebrow (HP:0005338)2.01022358
74Distal lower limb muscle weakness (HP:0009053)2.00456737
75Wormian bones (HP:0002645)2.00113095
76Abnormality of the 4th metacarpal (HP:0010012)1.98307733
77Increased variability in muscle fiber diameter (HP:0003557)1.96144271
78Shoulder girdle muscle weakness (HP:0003547)1.94705286
79Centrally nucleated skeletal muscle fibers (HP:0003687)1.94671776
80Turricephaly (HP:0000262)1.94622925
81Epidermoid cyst (HP:0200040)1.94439738
82Bladder diverticulum (HP:0000015)1.94307947
83Abnormality of the distal phalanx of the thumb (HP:0009617)1.93734875
84Hypolipoproteinemia (HP:0010981)1.92491481
85Abnormality of skeletal muscle fiber size (HP:0012084)1.91561403
86Aneurysm (HP:0002617)1.91110744
87Vertebral clefting (HP:0008428)1.89498864
88Glioma (HP:0009733)1.89076350
89Elfin facies (HP:0004428)1.88066131
90Hypoalphalipoproteinemia (HP:0003233)1.87875190
91Malignant gastrointestinal tract tumors (HP:0006749)1.87098331
92Gastrointestinal carcinoma (HP:0002672)1.87098331
93Proximal placement of thumb (HP:0009623)1.86528535
94Macroorchidism (HP:0000053)1.85736194
95Thin bony cortex (HP:0002753)1.84348249
96Adenoma sebaceum (HP:0009720)1.84207487
97Angiofibromas (HP:0010615)1.84207487
98Ankyloglossia (HP:0010296)1.83838782
99Vertebral arch anomaly (HP:0008438)1.83309659
100Blue sclerae (HP:0000592)1.82984957
101Lower limb amyotrophy (HP:0007210)1.82401139
102Arnold-Chiari malformation (HP:0002308)1.82269773
103Hypopigmentation of the fundus (HP:0007894)1.82194761
104Aortic dissection (HP:0002647)1.81380896
105Relative macrocephaly (HP:0004482)1.79999226
106Selective tooth agenesis (HP:0001592)1.79746711
107Increased mean platelet volume (HP:0011877)1.78641074
108Dilatation of the ascending aorta (HP:0005111)1.78553951
109Aortic aneurysm (HP:0004942)1.77040966
110Mitral regurgitation (HP:0001653)1.76946092
111Pterygium (HP:0001059)1.76498380
112Abnormality of the calcaneus (HP:0008364)1.76232358
113Missing ribs (HP:0000921)1.76059614
114Wrist flexion contracture (HP:0001239)1.75204668
115Rhabdomyosarcoma (HP:0002859)1.74553987
116Peritonitis (HP:0002586)1.73432050
117Long palpebral fissure (HP:0000637)1.73334857
118Overgrowth (HP:0001548)1.73037036
119Trismus (HP:0000211)1.72738258
120Elbow flexion contracture (HP:0002987)1.72707178
121Colon cancer (HP:0003003)1.72585857
122Abnormal ossification of hand bones (HP:0005921)1.71974210
123Buphthalmos (HP:0000557)1.70487501
124Round ear (HP:0100830)1.70269052
125Short humerus (HP:0005792)1.70200186
126Hepatocellular carcinoma (HP:0001402)1.70062276
127Abnormality of carpal bone ossification (HP:0006257)1.70062041
128Overriding aorta (HP:0002623)1.69897233
129Neoplasm of striated muscle (HP:0009728)1.68773691
130Deep philtrum (HP:0002002)1.68029177
131Hyporeflexia of lower limbs (HP:0002600)1.67542261
132Limb-girdle muscle weakness (HP:0003325)1.67253982
133Abnormality of the acetabulum (HP:0003170)1.67184040
134Volvulus (HP:0002580)1.67059453
135Coronal craniosynostosis (HP:0004440)1.66358683
136Patellar dislocation (HP:0002999)1.66150307
137Microglossia (HP:0000171)1.66114287
138Resting tremor (HP:0002322)1.65775488
139Broad metatarsal (HP:0001783)1.65287220
140Abnormality of the distal phalanges of the toes (HP:0010182)1.64802070
141Hyperextensible skin (HP:0000974)1.64207005
142Abnormality of the musculature of the pelvis (HP:0001469)1.63700730
143Abnormality of the hip-girdle musculature (HP:0001445)1.63700730
144Myocardial infarction (HP:0001658)1.62273968
145Abnormality of the diencephalon (HP:0010662)1.62063953
146Nemaline bodies (HP:0003798)1.61444311
147Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.60927941
148Insomnia (HP:0100785)1.60898672
149Breech presentation (HP:0001623)1.60482984
150Abnormality of the gastric mucosa (HP:0004295)1.60355880
151Intestinal polyp (HP:0005266)1.59890334
152Exercise-induced myalgia (HP:0003738)1.59352566
153Dysmetric saccades (HP:0000641)1.57904541
154Intestinal polyposis (HP:0200008)1.57644571
155Complement deficiency (HP:0004431)1.57015640
156Uterine leiomyosarcoma (HP:0002891)1.56903977
157Leiomyosarcoma (HP:0100243)1.56903977
158Cervical subluxation (HP:0003308)1.56691301
159Cubitus valgus (HP:0002967)1.55583708
160Metaphyseal cupping (HP:0003021)1.55407182
161Overlapping toe (HP:0001845)1.54885178
162Muscle fiber inclusion bodies (HP:0100299)1.54209708
163Cupped ribs (HP:0000887)1.53582099
164Flat cornea (HP:0007720)1.53017619
165Neonatal death (HP:0003811)1.52728153
166Biconcave vertebral bodies (HP:0004586)1.52456929

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.97303474
2TRIB33.89479784
3LATS13.18254235
4EEF2K3.14796325
5CDK123.10511102
6SMG12.93612492
7LATS22.47097580
8MAP3K102.42297100
9NEK12.16631740
10TTN2.11257918
11PDGFRA2.08202808
12MST1R2.04641557
13SCYL22.04346489
14IRAK32.00622326
15CDC71.96825791
16PRPF4B1.92431136
17PTK61.84324781
18ALK1.83436742
19EPHA21.79399667
20ICK1.77771218
21RIPK11.70359245
22DDR21.69762965
23BMX1.65239233
24NEK21.57448319
25MTOR1.41885041
26SIK11.41220570
27STK31.40636827
28CDK61.38976270
29RPS6KB21.36892812
30TYRO31.32770859
31EIF2AK11.31410781
32PAK21.24336081
33NTRK11.19341036
34PBK1.17772426
35KSR21.14058075
36PRKD31.08793961
37NME21.08573248
38LRRK21.08456274
39TTK1.07503124
40RET1.03215741
41PAK41.01766975
42PTK20.98632063
43MAP3K80.98504081
44PAK60.98288454
45CDK40.97187266
46ERN10.95291914
47KSR10.95092769
48FGFR10.94943821
49PDK30.94002053
50PDK40.94002053
51MET0.93616837
52ERBB40.90157298
53MAP3K90.89025243
54CAMK1D0.86945823
55PASK0.86657966
56TAF10.84695910
57ARAF0.81150814
58FLT30.80767892
59FGFR20.80470991
60PDGFRB0.80289632
61STK100.80263216
62FER0.79739218
63DMPK0.79711090
64STK240.78873301
65CAMK1G0.76733573
66STK38L0.75969628
67CHEK10.74583735
68MAP3K20.73551114
69TRPM70.73010932
70MOS0.72811957
71PNCK0.72236616
72BRAF0.67998531
73TGFBR10.66702667
74FGFR40.66480796
75MAP3K130.65714580
76CSNK1D0.65325726
77STK380.63632926
78CSNK1E0.63148365
79CDK20.61640439
80PAK30.61594622
81FRK0.61019215
82TESK10.58447001
83DYRK1B0.57287316
84NEK90.56085925
85SGK30.54491810
86ATM0.53102867
87AKT20.51369898
88WEE10.51343662
89CDK70.50839180
90MELK0.50670584
91EPHB20.50438744
92TAOK20.49780688
93PDPK10.49498615
94CAMKK10.48790248
95AKT30.48658135
96TAOK10.48652190
97PLK10.48020831
98ERBB20.46974043
99FGFR30.46645111
100RPS6KA20.46624734
101CHEK20.45595716
102LIMK10.45508236
103AURKB0.45197169
104BRSK10.44593326
105CLK10.43302905
106RPS6KA40.42932687
107MAP2K40.42430292
108CDK90.41985157
109TSSK60.41136841
110BRD40.40709132
111MAP3K70.40378826
112CDK80.40036059
113PRKDC0.39920809
114CDK10.39758451
115RPS6KA10.39370905
116GSK3A0.39273549
117PLK30.39097939
118CDC42BPA0.38819330
119RPS6KB10.37962112
120BRSK20.37748324
121MAP2K10.37506782
122ILK0.36357382
123EGFR0.35290511
124MAP3K60.35108720
125SRPK10.34969997
126ATR0.34304957
127WNK10.33736857
128MAP3K10.33685083
129MAPK110.33386404
130MAPK100.33325440

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.03326206
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.15356043
3Arginine biosynthesis_Homo sapiens_hsa002202.57746219
4One carbon pool by folate_Homo sapiens_hsa006702.32091759
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.19271686
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.91596659
7Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.91528636
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.84255759
9Selenocompound metabolism_Homo sapiens_hsa004501.75863032
10Lysine degradation_Homo sapiens_hsa003101.64307483
11Biosynthesis of amino acids_Homo sapiens_hsa012301.63976481
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63264141
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62041670
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58153586
15mTOR signaling pathway_Homo sapiens_hsa041501.52112854
16Central carbon metabolism in cancer_Homo sapiens_hsa052301.43877881
17Adherens junction_Homo sapiens_hsa045201.42161551
18Bladder cancer_Homo sapiens_hsa052191.37027726
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36766775
20Hippo signaling pathway_Homo sapiens_hsa043901.35990617
21Complement and coagulation cascades_Homo sapiens_hsa046101.31804701
22MicroRNAs in cancer_Homo sapiens_hsa052061.30367230
23RNA transport_Homo sapiens_hsa030131.26202824
24Tryptophan metabolism_Homo sapiens_hsa003801.25936046
25Chronic myeloid leukemia_Homo sapiens_hsa052201.24931053
26Proteoglycans in cancer_Homo sapiens_hsa052051.23800458
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22158268
28mRNA surveillance pathway_Homo sapiens_hsa030151.17805003
29Fatty acid degradation_Homo sapiens_hsa000711.17692438
30Bile secretion_Homo sapiens_hsa049761.16477329
31Endometrial cancer_Homo sapiens_hsa052131.13042251
32Carbon metabolism_Homo sapiens_hsa012001.12153235
33Focal adhesion_Homo sapiens_hsa045101.11462336
34Vitamin B6 metabolism_Homo sapiens_hsa007501.05308027
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04516798
36PPAR signaling pathway_Homo sapiens_hsa033201.04461687
37Basal cell carcinoma_Homo sapiens_hsa052171.04456260
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03196756
39Fatty acid biosynthesis_Homo sapiens_hsa000611.02638876
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01886950
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.01858253
42Glioma_Homo sapiens_hsa052141.00933504
43Small cell lung cancer_Homo sapiens_hsa052220.99500223
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98469331
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.96776979
46AMPK signaling pathway_Homo sapiens_hsa041520.96517125
47Systemic lupus erythematosus_Homo sapiens_hsa053220.94654783
48Dorso-ventral axis formation_Homo sapiens_hsa043200.92393876
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91883512
50Tight junction_Homo sapiens_hsa045300.91567559
51Non-small cell lung cancer_Homo sapiens_hsa052230.90898890
52Insulin resistance_Homo sapiens_hsa049310.89651841
53Fatty acid metabolism_Homo sapiens_hsa012120.89191740
54* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88783304
55Colorectal cancer_Homo sapiens_hsa052100.88066583
56TGF-beta signaling pathway_Homo sapiens_hsa043500.88054637
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87849872
58Thyroid cancer_Homo sapiens_hsa052160.87786866
59Glucagon signaling pathway_Homo sapiens_hsa049220.87505156
60ECM-receptor interaction_Homo sapiens_hsa045120.87042239
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86477391
62Dilated cardiomyopathy_Homo sapiens_hsa054140.86261077
63Viral carcinogenesis_Homo sapiens_hsa052030.85600678
64Cell cycle_Homo sapiens_hsa041100.84674081
65Prolactin signaling pathway_Homo sapiens_hsa049170.84037053
66Fat digestion and absorption_Homo sapiens_hsa049750.83784238
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83358880
68Butanoate metabolism_Homo sapiens_hsa006500.82805586
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81095943
70Insulin signaling pathway_Homo sapiens_hsa049100.80282280
71Renal cell carcinoma_Homo sapiens_hsa052110.79490340
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78812261
73Estrogen signaling pathway_Homo sapiens_hsa049150.78416925
74Pathways in cancer_Homo sapiens_hsa052000.77234284
75Inositol phosphate metabolism_Homo sapiens_hsa005620.76229559
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74937742
77Choline metabolism in cancer_Homo sapiens_hsa052310.73963800
78GnRH signaling pathway_Homo sapiens_hsa049120.73406989
79Other glycan degradation_Homo sapiens_hsa005110.73053882
80Fructose and mannose metabolism_Homo sapiens_hsa000510.72206137
81Amoebiasis_Homo sapiens_hsa051460.71645025
82Pyruvate metabolism_Homo sapiens_hsa006200.71364753
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.70535867
84Galactose metabolism_Homo sapiens_hsa000520.70055268
85Hedgehog signaling pathway_Homo sapiens_hsa043400.69844796
86VEGF signaling pathway_Homo sapiens_hsa043700.69773648
87Oocyte meiosis_Homo sapiens_hsa041140.68196672
88Melanogenesis_Homo sapiens_hsa049160.68151033
89Prostate cancer_Homo sapiens_hsa052150.67836781
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67619487
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67342690
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67189087
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66997792
94DNA replication_Homo sapiens_hsa030300.66865594
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65938486
96Pancreatic cancer_Homo sapiens_hsa052120.65804626
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.62517393
98FoxO signaling pathway_Homo sapiens_hsa040680.61207927
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60744240
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60706157
101Vibrio cholerae infection_Homo sapiens_hsa051100.60288598
102Thyroid hormone synthesis_Homo sapiens_hsa049180.59342658
103Hepatitis B_Homo sapiens_hsa051610.59067101
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.59027987
105Long-term potentiation_Homo sapiens_hsa047200.58928769
106N-Glycan biosynthesis_Homo sapiens_hsa005100.56496098
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.56348680
108Gap junction_Homo sapiens_hsa045400.56313045
109Starch and sucrose metabolism_Homo sapiens_hsa005000.56194286
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.56179056
111Prion diseases_Homo sapiens_hsa050200.56036401
112Propanoate metabolism_Homo sapiens_hsa006400.55948475
113Hepatitis C_Homo sapiens_hsa051600.55249904
114Endocytosis_Homo sapiens_hsa041440.55005029
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54848630
116Shigellosis_Homo sapiens_hsa051310.54703638
117ErbB signaling pathway_Homo sapiens_hsa040120.52742074
118HTLV-I infection_Homo sapiens_hsa051660.52536919
119Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52295093
120Viral myocarditis_Homo sapiens_hsa054160.52198749
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50546512
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.50190484
123Pentose phosphate pathway_Homo sapiens_hsa000300.49998999
124Wnt signaling pathway_Homo sapiens_hsa043100.49364711
125Phenylalanine metabolism_Homo sapiens_hsa003600.48942130
126Melanoma_Homo sapiens_hsa052180.48324636
127HIF-1 signaling pathway_Homo sapiens_hsa040660.48137099
128p53 signaling pathway_Homo sapiens_hsa041150.47775759
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47632070
130Notch signaling pathway_Homo sapiens_hsa043300.45482787
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45388223
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43984343
133Acute myeloid leukemia_Homo sapiens_hsa052210.42599038

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