ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein localization to kinetochore (GO:0034501)	5.76198581
2	DNA replication checkpoint (GO:0000076)	5.41150690
3	DNA strand elongation involved in DNA replication (GO:0006271)	5.28813005
4	DNA replication initiation (GO:0006270)	5.14452911
5	telomere maintenance via semi-conservative replication (GO:0032201)	5.03554487
6	DNA strand elongation (GO:0022616)	5.02736413
7	protein localization to chromosome, centromeric region (GO:0071459)	4.92511958
8	mitotic sister chromatid segregation (GO:0000070)	4.74527209
9	mitotic metaphase plate congression (GO:0007080)	4.67755514
10	* DNA unwinding involved in DNA replication (GO:0006268)	4.62084537
11	telomere maintenance via recombination (GO:0000722)	4.55648917
12	DNA replication-dependent nucleosome assembly (GO:0006335)	4.55004549
13	DNA replication-dependent nucleosome organization (GO:0034723)	4.55004549
14	establishment of integrated proviral latency (GO:0075713)	4.40179817
15	chromatin remodeling at centromere (GO:0031055)	4.33849735
16	CENP-A containing nucleosome assembly (GO:0034080)	4.33827877
17	* mitotic recombination (GO:0006312)	4.32739622
18	regulation of nuclear cell cycle DNA replication (GO:0033262)	4.26156582
19	mitotic chromosome condensation (GO:0007076)	4.23157401
20	sister chromatid segregation (GO:0000819)	4.20204240
21	attachment of spindle microtubules to kinetochore (GO:0008608)	4.13751239
22	metaphase plate congression (GO:0051310)	4.13069181
23	telomere maintenance via telomere lengthening (GO:0010833)	4.03669727
24	kinetochore organization (GO:0051383)	4.02717725
25	DNA replication-independent nucleosome assembly (GO:0006336)	3.98832422
26	DNA replication-independent nucleosome organization (GO:0034724)	3.98832422
27	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.92134532
28	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.89818705
29	proteasome assembly (GO:0043248)	3.84719981
30	mitotic nuclear envelope disassembly (GO:0007077)	3.80667823
31	nucleobase biosynthetic process (GO:0046112)	3.78214649
32	formation of translation preinitiation complex (GO:0001731)	3.76332325
33	maturation of SSU-rRNA (GO:0030490)	3.73470240
34	kinetochore assembly (GO:0051382)	3.71635360
35	nuclear pore organization (GO:0006999)	3.70189621
36	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.68118766
37	DNA ligation (GO:0006266)	3.67399601
38	establishment of chromosome localization (GO:0051303)	3.64754378
39	histone exchange (GO:0043486)	3.61220638
40	nuclear pore complex assembly (GO:0051292)	3.59039744
41	meiotic chromosome segregation (GO:0045132)	3.56151227
42	folic acid-containing compound biosynthetic process (GO:0009396)	3.54858533
43	establishment of viral latency (GO:0019043)	3.53847515
44	ribosomal small subunit biogenesis (GO:0042274)	3.51910244
45	purine nucleobase biosynthetic process (GO:0009113)	3.50761209
46	nuclear envelope disassembly (GO:0051081)	3.49295347
47	membrane disassembly (GO:0030397)	3.49295347
48	ribosome biogenesis (GO:0042254)	3.48139334
49	regulation of spindle organization (GO:0090224)	3.44988328
50	regulation of telomere maintenance via telomerase (GO:0032210)	3.43501371
51	ribonucleoprotein complex biogenesis (GO:0022613)	3.41792269
52	regulation of mitochondrial translation (GO:0070129)	3.40763021
53	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.39013551
54	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.39013551
55	protein localization to chromosome (GO:0034502)	3.36460924
56	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.34827473
57	* DNA duplex unwinding (GO:0032508)	3.34167768
58	DNA catabolic process, exonucleolytic (GO:0000738)	3.33686671
59	* DNA geometric change (GO:0032392)	3.33091210
60	chromatin assembly or disassembly (GO:0006333)	3.30800023
61	ribosomal small subunit assembly (GO:0000028)	3.30084458
62	ribosomal large subunit biogenesis (GO:0042273)	3.29796214
63	spindle checkpoint (GO:0031577)	3.29575602
64	rRNA modification (GO:0000154)	3.28617380
65	non-recombinational repair (GO:0000726)	3.25872641
66	double-strand break repair via nonhomologous end joining (GO:0006303)	3.25872641
67	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.24837397
68	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.24566802
69	viral transcription (GO:0019083)	3.24160576
70	translesion synthesis (GO:0019985)	3.21940040
71	chromosome segregation (GO:0007059)	3.21348115
72	translational termination (GO:0006415)	3.20398517
73	heterochromatin organization (GO:0070828)	3.20234550
74	negative regulation of chromosome segregation (GO:0051985)	3.20047571
75	regulation of chromosome segregation (GO:0051983)	3.19759317
76	synapsis (GO:0007129)	3.18781443
77	spindle assembly checkpoint (GO:0071173)	3.18108519
78	IMP biosynthetic process (GO:0006188)	3.16567403
79	mitotic sister chromatid cohesion (GO:0007064)	3.16185982
80	negative regulation of mitotic sister chromatid separation (GO:2000816)	3.16079591
81	negative regulation of mitotic sister chromatid segregation (GO:0033048)	3.16079591
82	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	3.16079591
83	negative regulation of sister chromatid segregation (GO:0033046)	3.16079591
84	pseudouridine synthesis (GO:0001522)	3.14545976
85	protein K6-linked ubiquitination (GO:0085020)	3.14357820
86	base-excision repair (GO:0006284)	3.11149360
87	replication fork processing (GO:0031297)	3.10893069
88	positive regulation of DNA-dependent DNA replication (GO:2000105)	3.10840875
89	DNA topological change (GO:0006265)	3.10235653
90	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.09842661
91	deoxyribonucleotide biosynthetic process (GO:0009263)	3.08994462
92	spliceosomal snRNP assembly (GO:0000387)	3.08967880
93	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	3.08504201
94	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	3.07099504
95	* regulation of double-strand break repair via homologous recombination (GO:0010569)	3.06473715
96	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.05913077
97	negative regulation of ligase activity (GO:0051352)	3.05913077
98	postreplication repair (GO:0006301)	3.05534833
99	mitotic spindle assembly checkpoint (GO:0007094)	3.05493075
100	rRNA processing (GO:0006364)	3.04899608
101	positive regulation of chromosome segregation (GO:0051984)	3.04414698
102	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.04085657
103	regulation of mitotic metaphase/anaphase transition (GO:0030071)	3.03775149
104	transcription-coupled nucleotide-excision repair (GO:0006283)	3.03569618
105	telomere organization (GO:0032200)	3.02867851
106	telomere maintenance (GO:0000723)	3.02857389
107	spliceosomal complex assembly (GO:0000245)	3.02854967
108	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.02278108
109	mismatch repair (GO:0006298)	3.01841909
110	mitotic spindle checkpoint (GO:0071174)	3.01700287
111	negative regulation of cell cycle G2/M phase transition (GO:1902750)	2.99657451
112	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	2.98232254
113	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	2.98201085
114	ATP-dependent chromatin remodeling (GO:0043044)	2.98058504
115	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.97925175
116	ribosome assembly (GO:0042255)	2.96721547
117	L-serine metabolic process (GO:0006563)	2.96719791
118	* DNA conformation change (GO:0071103)	2.96601825
119	IMP metabolic process (GO:0046040)	2.96595431
120	DNA replication (GO:0006260)	2.96345223
121	rRNA metabolic process (GO:0016072)	2.94628846
122	translational initiation (GO:0006413)	2.94601902
123	regulation of mitotic spindle organization (GO:0060236)	2.93168174
124	regulation of centrosome cycle (GO:0046605)	2.92964454
125	G1/S transition of mitotic cell cycle (GO:0000082)	2.90382042
126	cell cycle G1/S phase transition (GO:0044843)	2.90382042
127	chromosome condensation (GO:0030261)	2.89869247

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	9.96329982
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.83548591
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	4.26120291
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.06725471
5	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.61884270
6	* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.24487231
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.18486431
8	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.92740535
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.80129529
10	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.75976960
11	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.70182008
12	* CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.56854590
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.55967977
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.51563051
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.50402933
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.49784274
17	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.35787005
18	AR_21909140_ChIP-Seq_LNCAP_Human	2.35258849
19	* CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.31814640
20	XRN2_22483619_ChIP-Seq_HELA_Human	2.18642015
21	* NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.15410487
22	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.15364315
23	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	2.09042462
24	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.04594150
25	* VDR_23849224_ChIP-Seq_CD4+_Human	1.96564392
26	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.91105845
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.88593661
28	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.85957042
29	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.85957042
30	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.85957042
31	DCP1A_22483619_ChIP-Seq_HELA_Human	1.83638508
32	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.83520224
33	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.79672624
34	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.79398939
35	* KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.76188345
36	TTF2_22483619_ChIP-Seq_HELA_Human	1.75742237
37	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.72663588
38	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.68888288
39	GABP_19822575_ChIP-Seq_HepG2_Human	1.68871335
40	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.67225796
41	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.63545812
42	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.56481807
43	* THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.56479447
44	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.55971915
45	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.55686347
46	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.54678495
47	* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.50104325
48	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.48094710
49	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.47013897
50	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.44744149
51	ELK1_19687146_ChIP-ChIP_HELA_Human	1.44184623
52	CIITA_25753668_ChIP-Seq_RAJI_Human	1.43496234
53	* ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.41040422
54	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.40085273
55	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.39155211
56	KDM5A_27292631_Chip-Seq_BREAST_Human	1.38263792
57	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.29752189
58	MYC_22102868_ChIP-Seq_BL_Human	1.27464344
59	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.24353663
60	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.23921864
61	* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.23864766
62	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.23547481
63	* HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.22438528
64	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.19501523
65	* EGR1_19374776_ChIP-ChIP_THP-1_Human	1.16547226
66	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.15892896
67	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.15408736
68	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.14221126
69	* SRF_21415370_ChIP-Seq_HL-1_Mouse	1.09398738
70	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.09335984
71	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.09257981
72	* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.08363614
73	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.07662316
74	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.05796691
75	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	1.04763063
76	TFEB_21752829_ChIP-Seq_HELA_Human	1.01245000
77	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.99966769
78	MYC_18940864_ChIP-ChIP_HL60_Human	0.99684228
79	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.99037192
80	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.98513276
81	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.97219775
82	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.97203898
83	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.96640515
84	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.95924584
85	* ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.93431333
86	TCF3_18692474_ChIP-Seq_MESCs_Mouse	0.93385177
87	* FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.92907052
88	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.92287421
89	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.92216849
90	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.91436008
91	IRF1_19129219_ChIP-ChIP_H3396_Human	0.89376488
92	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.89253380
93	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.88509407
94	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.87614400
95	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.87579907
96	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.87057689
97	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.86184197
98	* OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.85860843
99	* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.84790480
100	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.84034683
101	* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.83068417
102	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.82609534
103	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.82598928
104	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.81574419
105	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.81431465
106	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.81035363
107	SPI1_23547873_ChIP-Seq_NB4_Human	0.80259648
108	* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.79159581
109	VDR_21846776_ChIP-Seq_THP-1_Human	0.79103956
110	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.78874401
111	* SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.78182131
112	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.75889238
113	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.75564059
114	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.75522724
115	ZNF263_19887448_ChIP-Seq_K562_Human	0.73878606
116	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.73383546
117	* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.72181556
118	* TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.68886349
119	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.68796036
120	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.67031401
121	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.66381285
122	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.65565737

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	5.28528410
2	MP0008057_abnormal_DNA_replication	4.94275941
3	MP0010094_abnormal_chromosome_stability	4.93096248
4	MP0004957_abnormal_blastocyst_morpholog	4.78178080
5	MP0003111_abnormal_nucleus_morphology	4.59074886
6	MP0003077_abnormal_cell_cycle	4.12226730
7	MP0008058_abnormal_DNA_repair	3.19228091
8	MP0008932_abnormal_embryonic_tissue	2.93307734
9	MP0003123_paternal_imprinting	2.61523828
10	MP0008007_abnormal_cellular_replicative	2.59172716
11	* MP0000350_abnormal_cell_proliferation	2.37923882
12	* MP0001730_embryonic_growth_arrest	2.24535263
13	MP0008877_abnormal_DNA_methylation	2.20755624
14	MP0010352_gastrointestinal_tract_polyps	2.16875004
15	MP0006292_abnormal_olfactory_placode	2.16369322
16	MP0002396_abnormal_hematopoietic_system	2.03163786
17	MP0003890_abnormal_embryonic-extraembry	1.99710581
18	MP0009697_abnormal_copulation	1.99456952
19	MP0001672_abnormal_embryogenesis/_devel	1.94448259
20	MP0005380_embryogenesis_phenotype	1.94448259
21	MP0003786_premature_aging	1.88350345
22	MP0003121_genomic_imprinting	1.74700321
23	MP0000490_abnormal_crypts_of	1.74337563
24	MP0004147_increased_porphyrin_level	1.74001839
25	* MP0001697_abnormal_embryo_size	1.71595603
26	MP0003984_embryonic_growth_retardation	1.69316641
27	* MP0002085_abnormal_embryonic_tissue	1.65925987
28	MP0002088_abnormal_embryonic_growth/wei	1.65802136
29	MP0003718_maternal_effect	1.64954713
30	MP0002080_prenatal_lethality	1.55582612
31	* MP0000313_abnormal_cell_death	1.53372632
32	MP0003315_abnormal_perineum_morphology	1.51511249
33	MP0002084_abnormal_developmental_patter	1.46271678
34	MP0004264_abnormal_extraembryonic_tissu	1.42021582
35	MP0001293_anophthalmia	1.41865173
36	MP0010307_abnormal_tumor_latency	1.41406855
37	MP0010030_abnormal_orbit_morphology	1.40541701
38	MP0006036_abnormal_mitochondrial_physio	1.40298193
39	MP0002210_abnormal_sex_determination	1.40067341
40	MP0002086_abnormal_extraembryonic_tissu	1.40006264
41	MP0009379_abnormal_foot_pigmentation	1.39336909
42	MP0002019_abnormal_tumor_incidence	1.38077061
43	MP0001346_abnormal_lacrimal_gland	1.38070350
44	MP0002653_abnormal_ependyma_morphology	1.34962516
45	MP0004197_abnormal_fetal_growth/weight/	1.27799304
46	MP0001145_abnormal_male_reproductive	1.24543157
47	MP0002938_white_spotting	1.21829814
48	MP0002163_abnormal_gland_morphology	1.17462219
49	MP0005075_abnormal_melanosome_morpholog	1.16184565
50	MP0003119_abnormal_digestive_system	1.10357801
51	MP0001929_abnormal_gametogenesis	1.10067471
52	MP0001529_abnormal_vocalization	1.10058905
53	MP0004808_abnormal_hematopoietic_stem	1.08481767
54	MP0008995_early_reproductive_senescence	1.06616682
55	MP0000372_irregular_coat_pigmentation	1.05725914
56	MP0005394_taste/olfaction_phenotype	1.02394772
57	MP0005499_abnormal_olfactory_system	1.02394772
58	MP0000653_abnormal_sex_gland	1.01977413
59	MP0003937_abnormal_limbs/digits/tail_de	1.01042300
60	MP0004133_heterotaxia	0.98839314
61	MP0009333_abnormal_splenocyte_physiolog	0.97689870
62	MP0003567_abnormal_fetal_cardiomyocyte	0.93443031
63	MP0003938_abnormal_ear_development	0.93191141
64	MP0000049_abnormal_middle_ear	0.92553847
65	MP0005257_abnormal_intraocular_pressure	0.91798503
66	MP0000703_abnormal_thymus_morphology	0.90692609
67	MP0002092_abnormal_eye_morphology	0.87457650
68	MP0005501_abnormal_skin_physiology	0.86790226
69	MP0002111_abnormal_tail_morphology	0.85920007
70	MP0006035_abnormal_mitochondrial_morpho	0.85824284
71	MP0008789_abnormal_olfactory_epithelium	0.85432249
72	MP0002722_abnormal_immune_system	0.84037800
73	MP0003941_abnormal_skin_development	0.82566718
74	MP0002160_abnormal_reproductive_system	0.82128382
75	MP0005384_cellular_phenotype	0.81764200
76	MP0000358_abnormal_cell_content/	0.81758517
77	MP0001764_abnormal_homeostasis	0.81242399
78	MP0003699_abnormal_female_reproductive	0.80662257
79	MP0001119_abnormal_female_reproductive	0.79576996
80	MP0002398_abnormal_bone_marrow	0.79492447
81	MP0000689_abnormal_spleen_morphology	0.78868952
82	MP0005076_abnormal_cell_differentiation	0.78127758
83	MP0002697_abnormal_eye_size	0.77922859
84	MP0003186_abnormal_redox_activity	0.77910857
85	MP0003011_delayed_dark_adaptation	0.77592261
86	MP0000428_abnormal_craniofacial_morphol	0.77068616
87	MP0006072_abnormal_retinal_apoptosis	0.76848079
88	MP0002161_abnormal_fertility/fecundity	0.76392262
89	MP0001286_abnormal_eye_development	0.75693563
90	MP0001849_ear_inflammation	0.74817276
91	MP0003763_abnormal_thymus_physiology	0.73985678
92	MP0002234_abnormal_pharynx_morphology	0.73551518
93	MP0005621_abnormal_cell_physiology	0.72816599
94	MP0002132_abnormal_respiratory_system	0.72652917
95	MP0001881_abnormal_mammary_gland	0.72150695
96	MP0000858_altered_metastatic_potential	0.71031603
97	MP0009672_abnormal_birth_weight	0.70668610
98	MP0009703_decreased_birth_body	0.70542055
99	MP0001545_abnormal_hematopoietic_system	0.70473412
100	MP0005397_hematopoietic_system_phenotyp	0.70473412
101	MP0000432_abnormal_head_morphology	0.69137409
102	MP0001661_extended_life_span	0.68304583
103	MP0002429_abnormal_blood_cell	0.65772102
104	MP0003806_abnormal_nucleotide_metabolis	0.65082000
105	MP0003136_yellow_coat_color	0.65043053
106	MP0000566_synostosis	0.65039018
107	MP0002233_abnormal_nose_morphology	0.64367860
108	MP0005266_abnormal_metabolism	0.63946537
109	MP0005389_reproductive_system_phenotype	0.63705526
110	MP0009053_abnormal_anal_canal	0.63697998
111	MP0002114_abnormal_axial_skeleton	0.63140379
112	MP0000647_abnormal_sebaceous_gland	0.62612807
113	MP0003705_abnormal_hypodermis_morpholog	0.62580271
114	MP0002932_abnormal_joint_morphology	0.61990727
115	MP0005395_other_phenotype	0.60733318
116	MP0000477_abnormal_intestine_morphology	0.59799095
117	MP0002102_abnormal_ear_morphology	0.59482294
118	MP0002736_abnormal_nociception_after	0.59443941
119	MP0003698_abnormal_male_reproductive	0.59394588
120	MP0004233_abnormal_muscle_weight	0.58314245
121	MP0002127_abnormal_cardiovascular_syste	0.57851928
122	MP0002277_abnormal_respiratory_mucosa	0.57524266
123	MP0002751_abnormal_autonomic_nervous	0.56549133
124	MP0001727_abnormal_embryo_implantation	0.56326237
125	MP0003787_abnormal_imprinting	0.55340460
126	MP0005410_abnormal_fertilization	0.55297954
127	MP0002095_abnormal_skin_pigmentation	0.55174469
128	MP0003935_abnormal_craniofacial_develop	0.55098251
129	MP0003861_abnormal_nervous_system	0.54465193
130	MP0003943_abnormal_hepatobiliary_system	0.54131906
131	MP0001919_abnormal_reproductive_system	0.53220166
132	MP0005379_endocrine/exocrine_gland_phen	0.51299380
133	MP0005084_abnormal_gallbladder_morpholo	0.51022124
134	MP0003936_abnormal_reproductive_system	0.50643014
135	MP0000631_abnormal_neuroendocrine_gland	0.48576606

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromsome breakage (HP:0040012)	5.04310910
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	5.02752272
3	Birth length less than 3rd percentile (HP:0003561)	4.63722287
4	Ependymoma (HP:0002888)	3.98142950
5	Breast hypoplasia (HP:0003187)	3.92347302
6	Reticulocytopenia (HP:0001896)	3.91607387
7	Meckel diverticulum (HP:0002245)	3.81507338
8	Abnormality of the ileum (HP:0001549)	3.63263918
9	Abnormality of the preputium (HP:0100587)	3.54498829
10	Abnormality of chromosome stability (HP:0003220)	3.53358600
11	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.52999713
12	Acute necrotizing encephalopathy (HP:0006965)	3.42862603
13	Rhabdomyosarcoma (HP:0002859)	3.42370443
14	Abnormal mitochondria in muscle tissue (HP:0008316)	3.37424311
15	Colon cancer (HP:0003003)	3.36408698
16	Medulloblastoma (HP:0002885)	3.34248393
17	Impulsivity (HP:0100710)	3.22382769
18	Patellar aplasia (HP:0006443)	3.17221014
19	Acute encephalopathy (HP:0006846)	3.10133138
20	Aplasia/Hypoplasia of the patella (HP:0006498)	3.10068548
21	Abnormality of cells of the erythroid lineage (HP:0012130)	3.09475309
22	Duodenal stenosis (HP:0100867)	3.08141323
23	Small intestinal stenosis (HP:0012848)	3.08141323
24	Oral leukoplakia (HP:0002745)	3.02265650
25	Abnormal lung lobation (HP:0002101)	3.00160749
26	Multiple enchondromatosis (HP:0005701)	3.00055041
27	Increased CSF lactate (HP:0002490)	2.94579502
28	Abnormal number of erythroid precursors (HP:0012131)	2.94456763
29	Absent radius (HP:0003974)	2.93796653
30	Nephroblastoma (Wilms tumor) (HP:0002667)	2.89539121
31	Selective tooth agenesis (HP:0001592)	2.88015954
32	Supernumerary spleens (HP:0009799)	2.87153981
33	Aplastic anemia (HP:0001915)	2.84936288
34	Carpal bone hypoplasia (HP:0001498)	2.79591950
35	Neoplasm of striated muscle (HP:0009728)	2.77702070
36	Mitochondrial inheritance (HP:0001427)	2.77275958
37	Absent forearm bone (HP:0003953)	2.75904311
38	Aplasia involving forearm bones (HP:0009822)	2.75904311
39	Rib fusion (HP:0000902)	2.75735979
40	Myelodysplasia (HP:0002863)	2.75083643
41	Absent thumb (HP:0009777)	2.72592087
42	Embryonal renal neoplasm (HP:0011794)	2.67000223
43	Agnosia (HP:0010524)	2.66563797
44	Bone marrow hypocellularity (HP:0005528)	2.65890602
45	Ectopic kidney (HP:0000086)	2.65712038
46	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.65556806
47	Rough bone trabeculation (HP:0100670)	2.64671505
48	Progressive macrocephaly (HP:0004481)	2.64405712
49	Increased hepatocellular lipid droplets (HP:0006565)	2.61152296
50	Trismus (HP:0000211)	2.60528503
51	Abnormality of the anterior horn cell (HP:0006802)	2.60513520
52	Degeneration of anterior horn cells (HP:0002398)	2.60513520
53	Triphalangeal thumb (HP:0001199)	2.59584847
54	Microretrognathia (HP:0000308)	2.57579018
55	Hepatocellular necrosis (HP:0001404)	2.56947397
56	Sloping forehead (HP:0000340)	2.56882517
57	Abnormality of the labia minora (HP:0012880)	2.56407378
58	Increased serum lactate (HP:0002151)	2.56145891
59	Abnormality of the duodenum (HP:0002246)	2.53787802
60	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.49039653
61	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.49039653
62	Pallor (HP:0000980)	2.48666396
63	Cerebral edema (HP:0002181)	2.44332599
64	Abnormality of the astrocytes (HP:0100707)	2.43284451
65	Astrocytoma (HP:0009592)	2.43284451
66	Lipid accumulation in hepatocytes (HP:0006561)	2.43060580
67	Bilateral microphthalmos (HP:0007633)	2.42402661
68	Atresia of the external auditory canal (HP:0000413)	2.42378026
69	Abnormality of glycolysis (HP:0004366)	2.39445126
70	Increased serum pyruvate (HP:0003542)	2.37260687
71	Horseshoe kidney (HP:0000085)	2.36827774
72	Tracheoesophageal fistula (HP:0002575)	2.36803034
73	Macrocytic anemia (HP:0001972)	2.34640345
74	Abnormality of cochlea (HP:0000375)	2.33393880
75	Hepatic necrosis (HP:0002605)	2.33346709
76	Pancytopenia (HP:0001876)	2.32924403
77	Cleft eyelid (HP:0000625)	2.26841608
78	Cerebral hypomyelination (HP:0006808)	2.23781742
79	Premature ovarian failure (HP:0008209)	2.23445048
80	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.22990495
81	Glioma (HP:0009733)	2.21295108
82	Duplicated collecting system (HP:0000081)	2.21130734
83	Abnormal number of incisors (HP:0011064)	2.19091622
84	Abnormality of the carotid arteries (HP:0005344)	2.18343516
85	Aplasia/hypoplasia of the humerus (HP:0006507)	2.18275699
86	Lactic acidosis (HP:0003128)	2.15246989
87	Rectal fistula (HP:0100590)	2.15165289
88	Rectovaginal fistula (HP:0000143)	2.15165289
89	Secondary amenorrhea (HP:0000869)	2.14019440
90	Premature graying of hair (HP:0002216)	2.13506858
91	Increased nuchal translucency (HP:0010880)	2.12216017
92	Neoplasm of the pancreas (HP:0002894)	2.08911917
93	Clubbing of toes (HP:0100760)	2.08831490
94	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.07272528
95	Hypoplasia of the pons (HP:0012110)	2.04284075
96	Abnormality of alanine metabolism (HP:0010916)	2.02844035
97	Hyperalaninemia (HP:0003348)	2.02844035
98	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.02844035
99	Abnormality of DNA repair (HP:0003254)	2.00380959
100	Cafe-au-lait spot (HP:0000957)	1.98749561
101	Basal cell carcinoma (HP:0002671)	1.95990988
102	Abnormality of the renal collecting system (HP:0004742)	1.92282548
103	Increased intramyocellular lipid droplets (HP:0012240)	1.91330991
104	Glossoptosis (HP:0000162)	1.90402969
105	Type I transferrin isoform profile (HP:0003642)	1.90369565
106	Short thumb (HP:0009778)	1.90232624
107	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.89396221
108	Abnormality of abdominal situs (HP:0011620)	1.89242152
109	Abdominal situs inversus (HP:0003363)	1.89242152
110	Megaloblastic anemia (HP:0001889)	1.88468894
111	Neoplasm of the oral cavity (HP:0100649)	1.88394878
112	Renal Fanconi syndrome (HP:0001994)	1.87517150
113	Choanal atresia (HP:0000453)	1.86629211
114	11 pairs of ribs (HP:0000878)	1.86480677
115	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.86092185
116	Respiratory difficulties (HP:0002880)	1.85828587
117	Abnormal trabecular bone morphology (HP:0100671)	1.83957330
118	Missing ribs (HP:0000921)	1.83319750
119	Abnormality of the pons (HP:0007361)	1.82879365
120	Exercise intolerance (HP:0003546)	1.82423385
121	Fused cervical vertebrae (HP:0002949)	1.81573848
122	Cellular immunodeficiency (HP:0005374)	1.80869742
123	Abnormality of the salivary glands (HP:0010286)	1.80828036
124	Duplication of thumb phalanx (HP:0009942)	1.80725171
125	Intestinal fistula (HP:0100819)	1.80424103
126	Facial cleft (HP:0002006)	1.80412978
127	Microvesicular hepatic steatosis (HP:0001414)	1.79770276
128	Respiratory failure (HP:0002878)	1.78971411
129	Neoplasm of the colon (HP:0100273)	1.78906641
130	Progressive muscle weakness (HP:0003323)	1.78544700
131	Volvulus (HP:0002580)	1.78390827
132	Short humerus (HP:0005792)	1.78257447
133	Abnormality of serum amino acid levels (HP:0003112)	1.78155338
134	Leukodystrophy (HP:0002415)	1.77763077
135	Proximal placement of thumb (HP:0009623)	1.77510023
136	Cortical dysplasia (HP:0002539)	1.77273816
137	Hyperglycinemia (HP:0002154)	1.75948793
138	Squamous cell carcinoma (HP:0002860)	1.75126072
139	Arteriovenous malformation (HP:0100026)	1.73986826
140	Ureteral duplication (HP:0000073)	1.71817010

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	4.75965338
2	BUB1	4.61257506
3	WEE1	4.50301937
4	VRK2	3.82949455
5	CDK12	3.65969449
6	TTK	3.28742881
7	EIF2AK1	3.13799064
8	NEK2	3.04538259
9	ACVR1B	2.40828806
10	* PLK1	2.35732741
11	SRPK1	2.30472539
12	PLK4	2.29899653
13	CDK7	2.13132372
14	PDK2	2.12631175
15	BRSK2	2.09156256
16	NEK1	1.98870491
17	CHEK2	1.90748342
18	TAF1	1.87597399
19	TLK1	1.77787551
20	AURKB	1.77574777
21	VRK1	1.74985435
22	MKNK1	1.74788620
23	STK10	1.69692131
24	TESK2	1.66664174
25	NME2	1.62075170
26	ATR	1.59631845
27	STK16	1.58415954
28	TSSK6	1.56631514
29	AURKA	1.56219810
30	CCNB1	1.48066810
31	RPS6KA4	1.45653453
32	EIF2AK3	1.44877155
33	BRSK1	1.44386607
34	PLK3	1.38621835
35	MKNK2	1.36097184
36	CDK4	1.34540548
37	NUAK1	1.33576623
38	EPHA2	1.32336385
39	* CHEK1	1.31672731
40	RPS6KB2	1.31259781
41	DYRK3	1.29205630
42	GRK6	1.25746797
43	MAP3K8	1.21887666
44	PASK	1.19619070
45	STK4	1.15136526
46	SMG1	1.09689482
47	PAK4	1.04732774
48	EIF2AK2	1.03396775
49	BRD4	0.98439627
50	CDK2	0.92673298
51	ATM	0.92101147
52	CSF1R	0.91281215
53	PBK	0.90044004
54	BCKDK	0.87393388
55	SCYL2	0.86669319
56	TRIM28	0.85619107
57	CDK8	0.83345036
58	MELK	0.82952576
59	DAPK1	0.74185507
60	MAP4K1	0.74067488
61	CDK1	0.70903497
62	ZAK	0.70270782
63	PAK1	0.68454986
64	TGFBR1	0.66448789
65	ERBB4	0.65291257
66	ALK	0.62932089
67	MAP3K10	0.61178781
68	* CSNK2A1	0.60979031
69	GRK5	0.58989718
70	CSNK2A2	0.57535780
71	BRAF	0.56951716
72	BMPR1B	0.56431018
73	CDK6	0.55957806
74	WNK3	0.55931985
75	PRKCI	0.55477649
76	PIM1	0.55063624
77	WNK4	0.53975661
78	CSNK1G3	0.53613704
79	CLK1	0.53303935
80	GRK1	0.48360670
81	CSNK1G1	0.46066898
82	ADRBK2	0.45530690
83	EEF2K	0.39103150
84	MATK	0.38713343
85	PIM2	0.38276951
86	AKT2	0.37877385
87	NME1	0.37652165
88	ARAF	0.36782957
89	CSNK1E	0.36139346
90	RPS6KA5	0.35922979
91	MST4	0.35841730
92	CSNK1A1L	0.35737684
93	STK3	0.35165531
94	MAP3K11	0.34499823
95	OXSR1	0.33833328
96	DYRK2	0.32538819
97	CSNK1G2	0.30914674
98	CDK9	0.30398256
99	YES1	0.30297885
100	TESK1	0.30179029
101	FLT3	0.30123582
102	STK39	0.29772181
103	LATS2	0.29431276
104	MOS	0.28035680
105	CDK11A	0.27153200
106	STK38L	0.26540743
107	KDR	0.25939535
108	LIMK1	0.25822340
109	PRKDC	0.25695459
110	BMX	0.25655826
111	LATS1	0.25283509
112	LRRK2	0.24953083
113	MAPK14	0.24093368
114	BLK	0.24084653
115	TNIK	0.23767245
116	PNCK	0.22791634
117	CDK15	0.22270525
118	MAPKAPK5	0.20937645
119	CDK3	0.20590824
120	AKT3	0.20048932
121	CDK14	0.19408077
122	CDK18	0.19261457
123	CDK19	0.19117341
124	IRAK4	0.18644999
125	MTOR	0.18053469
126	AKT1	0.16777211

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	5.55246940
2	Mismatch repair_Homo sapiens_hsa03430	4.81825024
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.72281244
4	* Homologous recombination_Homo sapiens_hsa03440	3.41118436
5	Ribosome_Homo sapiens_hsa03010	3.39994437
6	Base excision repair_Homo sapiens_hsa03410	3.25713680
7	Spliceosome_Homo sapiens_hsa03040	3.19359700
8	Cell cycle_Homo sapiens_hsa04110	3.05200293
9	Nucleotide excision repair_Homo sapiens_hsa03420	2.99702928
10	RNA transport_Homo sapiens_hsa03013	2.98348162
11	RNA polymerase_Homo sapiens_hsa03020	2.96033362
12	Proteasome_Homo sapiens_hsa03050	2.81771792
13	One carbon pool by folate_Homo sapiens_hsa00670	2.65246063
14	* Fanconi anemia pathway_Homo sapiens_hsa03460	2.57059097
15	Pyrimidine metabolism_Homo sapiens_hsa00240	2.42435557
16	Non-homologous end-joining_Homo sapiens_hsa03450	2.20693799
17	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.18125718
18	Basal transcription factors_Homo sapiens_hsa03022	2.05393416
19	RNA degradation_Homo sapiens_hsa03018	1.86712435
20	mRNA surveillance pathway_Homo sapiens_hsa03015	1.75992634
21	p53 signaling pathway_Homo sapiens_hsa04115	1.73207712
22	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.67682629
23	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.50578403
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.37011866
25	Purine metabolism_Homo sapiens_hsa00230	1.19662124
26	Pyruvate metabolism_Homo sapiens_hsa00620	1.19334991
27	Oocyte meiosis_Homo sapiens_hsa04114	1.06094467
28	Fatty acid elongation_Homo sapiens_hsa00062	1.03470993
29	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.01584413
30	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.00005339
31	Folate biosynthesis_Homo sapiens_hsa00790	0.97628542
32	Alzheimers disease_Homo sapiens_hsa05010	0.95888187
33	Herpes simplex infection_Homo sapiens_hsa05168	0.94457947
34	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.92748544
35	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.90416268
36	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.89224078
37	Steroid biosynthesis_Homo sapiens_hsa00100	0.86069770
38	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.83741551
39	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.82844734
40	Propanoate metabolism_Homo sapiens_hsa00640	0.81646279
41	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.79486274
42	Viral carcinogenesis_Homo sapiens_hsa05203	0.78854613
43	Antigen processing and presentation_Homo sapiens_hsa04612	0.71939036
44	Pentose phosphate pathway_Homo sapiens_hsa00030	0.70703264
45	HTLV-I infection_Homo sapiens_hsa05166	0.70634157
46	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.64097665
47	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.62371271
48	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.60863921
49	Thyroid cancer_Homo sapiens_hsa05216	0.60855358
50	MicroRNAs in cancer_Homo sapiens_hsa05206	0.59555431
51	Huntingtons disease_Homo sapiens_hsa05016	0.59157865
52	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.57619546
53	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.56007680
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54260713
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.53365822
56	Sulfur relay system_Homo sapiens_hsa04122	0.53298515
57	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.51585783
58	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.51548359
59	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.51160636
60	Protein export_Homo sapiens_hsa03060	0.49231496
61	Selenocompound metabolism_Homo sapiens_hsa00450	0.48925379
62	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.46963588
63	Glutathione metabolism_Homo sapiens_hsa00480	0.46705854
64	Small cell lung cancer_Homo sapiens_hsa05222	0.45305775
65	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.45238367
66	Basal cell carcinoma_Homo sapiens_hsa05217	0.44063507
67	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.42874637
68	Primary immunodeficiency_Homo sapiens_hsa05340	0.42869709
69	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.41878435
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.41272093
71	Cardiac muscle contraction_Homo sapiens_hsa04260	0.40380183
72	Fatty acid metabolism_Homo sapiens_hsa01212	0.38639709
73	Legionellosis_Homo sapiens_hsa05134	0.36987897
74	Apoptosis_Homo sapiens_hsa04210	0.36800694
75	Hippo signaling pathway_Homo sapiens_hsa04390	0.36783197
76	Linoleic acid metabolism_Homo sapiens_hsa00591	0.36646880
77	Parkinsons disease_Homo sapiens_hsa05012	0.35377254
78	Galactose metabolism_Homo sapiens_hsa00052	0.34781668
79	Colorectal cancer_Homo sapiens_hsa05210	0.34412408
80	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.32824728
81	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.31414835
82	Bladder cancer_Homo sapiens_hsa05219	0.30942159
83	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.28038718
84	Arginine and proline metabolism_Homo sapiens_hsa00330	0.28025160
85	Notch signaling pathway_Homo sapiens_hsa04330	0.27499628
86	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.26658009
87	Alcoholism_Homo sapiens_hsa05034	0.25730680
88	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.25489127
89	* Pathways in cancer_Homo sapiens_hsa05200	0.24902023
90	Hepatitis B_Homo sapiens_hsa05161	0.24400505
91	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.24042875
92	Metabolic pathways_Homo sapiens_hsa01100	0.22894179
93	Peroxisome_Homo sapiens_hsa04146	0.22610112
94	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.21992478
95	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.21729343
96	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.21675802
97	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.21531613
98	Carbon metabolism_Homo sapiens_hsa01200	0.21413606
99	Lysine degradation_Homo sapiens_hsa00310	0.20608005
100	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.20064702
101	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.19615554
102	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.19594782
103	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.18643191
104	Measles_Homo sapiens_hsa05162	0.18388586
105	Sulfur metabolism_Homo sapiens_hsa00920	0.18357584
106	Oxidative phosphorylation_Homo sapiens_hsa00190	0.17745912
107	Butanoate metabolism_Homo sapiens_hsa00650	0.16470487
108	Shigellosis_Homo sapiens_hsa05131	0.16049177
109	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.14757495
110	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.13644628
111	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.13260479
112	Influenza A_Homo sapiens_hsa05164	0.13043694
113	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.12763628
114	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.12659004
115	Wnt signaling pathway_Homo sapiens_hsa04310	0.12298974
116	Prostate cancer_Homo sapiens_hsa05215	0.10169188
117	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.08823500
118	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.08663504
119	Non-small cell lung cancer_Homo sapiens_hsa05223	0.07809742
120	Phototransduction_Homo sapiens_hsa04744	0.07566482
121	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.06977685
122	Regulation of autophagy_Homo sapiens_hsa04140	0.06867992
123	Acute myeloid leukemia_Homo sapiens_hsa05221	0.06803476
124	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.06321709
125	Fatty acid degradation_Homo sapiens_hsa00071	0.06076159
126	mTOR signaling pathway_Homo sapiens_hsa04150	0.05770269
127	Ether lipid metabolism_Homo sapiens_hsa00565	0.05475343
128	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.05472499
129	Tryptophan metabolism_Homo sapiens_hsa00380	0.04797422
130	Nitrogen metabolism_Homo sapiens_hsa00910	0.01592138

RAD51

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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