RAD51AP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.83498550
2telomere maintenance via semi-conservative replication (GO:0032201)5.72171126
3DNA strand elongation (GO:0022616)5.55750229
4DNA replication initiation (GO:0006270)5.42575927
5DNA replication checkpoint (GO:0000076)5.29678719
6telomere maintenance via recombination (GO:0000722)5.25112761
7mitotic recombination (GO:0006312)5.06730545
8CENP-A containing nucleosome assembly (GO:0034080)5.03500839
9protein localization to kinetochore (GO:0034501)4.96794601
10chromatin remodeling at centromere (GO:0031055)4.93881100
11DNA unwinding involved in DNA replication (GO:0006268)4.85819642
12mitotic metaphase plate congression (GO:0007080)4.74303159
13kinetochore organization (GO:0051383)4.68093783
14DNA ligation (GO:0006266)4.56411878
15DNA replication-independent nucleosome organization (GO:0034724)4.53469397
16DNA replication-independent nucleosome assembly (GO:0006336)4.53469397
17telomere maintenance via telomere lengthening (GO:0010833)4.53429691
18establishment of integrated proviral latency (GO:0075713)4.51154300
19regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.36115416
20protein localization to chromosome, centromeric region (GO:0071459)4.31957210
21nucleotide-excision repair, DNA gap filling (GO:0006297)4.29200404
22metaphase plate congression (GO:0051310)4.18066288
23histone exchange (GO:0043486)4.15496148
24kinetochore assembly (GO:0051382)4.14201804
25attachment of spindle microtubules to kinetochore (GO:0008608)4.13181786
26DNA replication-dependent nucleosome assembly (GO:0006335)4.08378470
27DNA replication-dependent nucleosome organization (GO:0034723)4.08378470
28mitotic chromosome condensation (GO:0007076)4.05266831
29chromosome condensation (GO:0030261)3.98859168
30mitotic sister chromatid segregation (GO:0000070)3.97746409
31nucleobase biosynthetic process (GO:0046112)3.94878393
32regulation of nuclear cell cycle DNA replication (GO:0033262)3.91558290
33meiotic chromosome segregation (GO:0045132)3.91292632
34establishment of chromosome localization (GO:0051303)3.86821876
35purine nucleobase biosynthetic process (GO:0009113)3.78011526
36ribosomal small subunit assembly (GO:0000028)3.77922711
37mitotic G2/M transition checkpoint (GO:0044818)3.77032879
38regulation of sister chromatid segregation (GO:0033045)3.75438258
39regulation of mitotic sister chromatid separation (GO:0010965)3.75438258
40protein K6-linked ubiquitination (GO:0085020)3.68853504
41maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.67046306
42maturation of SSU-rRNA (GO:0030490)3.66728329
43sister chromatid segregation (GO:0000819)3.64364222
44regulation of DNA endoreduplication (GO:0032875)3.63017616
45DNA double-strand break processing (GO:0000729)3.62229936
46DNA packaging (GO:0006323)3.58422957
47deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.57175176
48DNA deamination (GO:0045006)3.56466966
49telomere maintenance (GO:0000723)3.55100642
50telomere organization (GO:0032200)3.53286661
51centriole replication (GO:0007099)3.52695061
52IMP biosynthetic process (GO:0006188)3.50799837
53mitotic nuclear envelope disassembly (GO:0007077)3.44205234
54regulation of mitotic spindle organization (GO:0060236)3.42166420
55mismatch repair (GO:0006298)3.41469707
56establishment of viral latency (GO:0019043)3.40087783
57regulation of spindle organization (GO:0090224)3.40021474
58chromatin assembly or disassembly (GO:0006333)3.36258292
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35083192
60spindle checkpoint (GO:0031577)3.34915185
61nuclear pore organization (GO:0006999)3.32298156
62transcription-coupled nucleotide-excision repair (GO:0006283)3.31241042
63translesion synthesis (GO:0019985)3.30814511
64non-recombinational repair (GO:0000726)3.30778832
65double-strand break repair via nonhomologous end joining (GO:0006303)3.30778832
66regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.28235633
67regulation of mitotic spindle checkpoint (GO:1903504)3.28235633
68* regulation of double-strand break repair via homologous recombination (GO:0010569)3.27786361
69deoxyribonucleotide biosynthetic process (GO:0009263)3.26666466
70proteasome assembly (GO:0043248)3.26458336
71negative regulation of mitosis (GO:0045839)3.26293864
72DNA synthesis involved in DNA repair (GO:0000731)3.23454283
73chromosome segregation (GO:0007059)3.23402775
74replication fork processing (GO:0031297)3.23352860
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.22489216
76ribosomal large subunit biogenesis (GO:0042273)3.22464683
77spliceosomal snRNP assembly (GO:0000387)3.21981451
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.21455439
79regulation of sister chromatid cohesion (GO:0007063)3.20180007
80ATP-dependent chromatin remodeling (GO:0043044)3.19530048
81regulation of chromosome segregation (GO:0051983)3.19269198
82nuclear pore complex assembly (GO:0051292)3.18798167
83negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.18331132
84negative regulation of sister chromatid segregation (GO:0033046)3.18331132
85negative regulation of mitotic sister chromatid separation (GO:2000816)3.18331132
86negative regulation of mitotic sister chromatid segregation (GO:0033048)3.18331132
87negative regulation of chromosome segregation (GO:0051985)3.18224802
88DNA duplex unwinding (GO:0032508)3.17958122
89DNA geometric change (GO:0032392)3.17846722
90regulation of mitotic metaphase/anaphase transition (GO:0030071)3.16970792
91negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.16902071
92DNA replication (GO:0006260)3.16818435
93protein localization to chromosome (GO:0034502)3.16579052
94microtubule depolymerization (GO:0007019)3.16441849
95negative regulation of DNA-dependent DNA replication (GO:2000104)3.15076410
96resolution of meiotic recombination intermediates (GO:0000712)3.15063502
97DNA strand renaturation (GO:0000733)3.13990623
98DNA catabolic process, exonucleolytic (GO:0000738)3.13352755
99membrane disassembly (GO:0030397)3.13167835
100nuclear envelope disassembly (GO:0051081)3.13167835
101spindle assembly checkpoint (GO:0071173)3.13087909
102regulation of centrosome cycle (GO:0046605)3.11805523
103ribosome biogenesis (GO:0042254)3.10643757
104regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.10316664
105heterochromatin organization (GO:0070828)3.09862721
106negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.09679897
107pore complex assembly (GO:0046931)3.09498985
108formation of translation preinitiation complex (GO:0001731)3.08705377
109DNA topological change (GO:0006265)3.08457455
110cell cycle G1/S phase transition (GO:0044843)3.08010588
111G1/S transition of mitotic cell cycle (GO:0000082)3.08010588
112somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07833816
113somatic hypermutation of immunoglobulin genes (GO:0016446)3.07833816
114ribonucleoprotein complex biogenesis (GO:0022613)3.07402053
115positive regulation of chromosome segregation (GO:0051984)3.06669381
116folic acid-containing compound biosynthetic process (GO:0009396)3.06183343
117mitotic cell cycle (GO:0000278)3.05646303
118rRNA processing (GO:0006364)3.05068334
119regulation of centriole replication (GO:0046599)3.04897660
120mitotic G2 DNA damage checkpoint (GO:0007095)3.04757231
121intra-S DNA damage checkpoint (GO:0031573)3.04368136
122mitotic sister chromatid cohesion (GO:0007064)3.04148477
123IMP metabolic process (GO:0046040)3.00619408
124mitotic spindle assembly checkpoint (GO:0007094)3.00547419
125postreplication repair (GO:0006301)3.00100052
126mitotic spindle checkpoint (GO:0071174)2.98835651
127DNA conformation change (GO:0071103)2.96523556
128regulation of mitotic sister chromatid segregation (GO:0033047)2.96310962

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.12322794
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.58253234
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.93738770
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.80634711
5* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.34921426
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.14246658
7* EST1_17652178_ChIP-ChIP_JURKAT_Human2.81078167
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.71394505
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68374265
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64877836
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.61552440
12* GABP_17652178_ChIP-ChIP_JURKAT_Human2.60613972
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.49188756
14AR_21909140_ChIP-Seq_LNCAP_Human2.46371788
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45406246
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.39155863
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.32426788
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29078254
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26415634
20* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20088158
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19791086
22* VDR_23849224_ChIP-Seq_CD4+_Human2.15510146
23XRN2_22483619_ChIP-Seq_HELA_Human2.13392379
24* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10950861
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08911061
26FOXP3_21729870_ChIP-Seq_TREG_Human2.05865558
27E2F7_22180533_ChIP-Seq_HELA_Human11.2152667
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90568693
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90198715
30DCP1A_22483619_ChIP-Seq_HELA_Human1.90023737
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86688780
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.80654682
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80437599
34* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78223344
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77896490
36TTF2_22483619_ChIP-Seq_HELA_Human1.76247622
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75528564
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74140084
39ELK1_19687146_ChIP-ChIP_HELA_Human1.71719276
40* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70598336
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.68042177
42GABP_19822575_ChIP-Seq_HepG2_Human1.66566289
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63357340
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60521366
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59305105
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55514881
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53360536
48* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52678693
49CIITA_25753668_ChIP-Seq_RAJI_Human1.50201775
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45556843
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.44928647
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43848831
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42279174
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.38743341
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.38285616
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28580739
57KDM5A_27292631_Chip-Seq_BREAST_Human1.27952907
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27830035
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27550007
60* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22516311
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20820217
62NANOG_16153702_ChIP-ChIP_HESCs_Human1.18920194
63EWS_26573619_Chip-Seq_HEK293_Human1.18009157
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17115106
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15291971
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.15245105
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14629574
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14135170
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14050476
70* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13340328
71MYC_18940864_ChIP-ChIP_HL60_Human1.11596472
72* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10664006
73* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09808600
74MYC_22102868_ChIP-Seq_BL_Human1.07755731
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.06755509
76FUS_26573619_Chip-Seq_HEK293_Human1.02789830
77SPI1_23547873_ChIP-Seq_NB4_Human0.98435352
78* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97331328
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96176946
80* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94896784
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94832860
82KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91859253
83TFEB_21752829_ChIP-Seq_HELA_Human0.91098742
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90941050
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90397202
86SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88116137
87* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86321154
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.84965675
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84553339
90* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80527648
91STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79308933
92RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77877834
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.77053080
94IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.75442181
95VDR_21846776_ChIP-Seq_THP-1_Human0.75240200
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74884266
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.72140471
98NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.68293273
99TCF3_18692474_ChIP-Seq_MEFs_Mouse0.67169563
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.66458925
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.66201789
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.65957587
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.65229111
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.65093869
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.64386020
106IRF1_19129219_ChIP-ChIP_H3396_Human0.63999812
107* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63713402
108NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.63505638
109SALL1_21062744_ChIP-ChIP_HESCs_Human0.63279021
110NANOG_21062744_ChIP-ChIP_HESCs_Human0.62778238
111SOX17_20123909_ChIP-Seq_XEN_Mouse0.62688214
112TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.62506951
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.62235937
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.60179798
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.60101131
116ESR1_15608294_ChIP-ChIP_MCF-7_Human0.57723941

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.69502596
2MP0008057_abnormal_DNA_replication5.53011303
3MP0010094_abnormal_chromosome_stability5.39337672
4MP0003111_abnormal_nucleus_morphology4.87789968
5MP0003077_abnormal_cell_cycle4.14577943
6MP0004957_abnormal_blastocyst_morpholog4.09674066
7MP0008058_abnormal_DNA_repair4.05561977
8MP0008007_abnormal_cellular_replicative2.93497606
9MP0002396_abnormal_hematopoietic_system2.88614891
10MP0008932_abnormal_embryonic_tissue2.67777386
11MP0008877_abnormal_DNA_methylation2.52250742
12MP0003786_premature_aging2.25914406
13MP0000350_abnormal_cell_proliferation2.07927987
14MP0001730_embryonic_growth_arrest1.92991575
15MP0000490_abnormal_crypts_of1.92948258
16MP0010307_abnormal_tumor_latency1.92008450
17MP0003123_paternal_imprinting1.71371772
18MP0006292_abnormal_olfactory_placode1.58605558
19MP0003806_abnormal_nucleotide_metabolis1.50190804
20MP0005380_embryogenesis_phenotype1.50096438
21MP0001672_abnormal_embryogenesis/_devel1.50096438
22MP0004808_abnormal_hematopoietic_stem1.49475820
23MP0000313_abnormal_cell_death1.48518475
24MP0001697_abnormal_embryo_size1.44505340
25MP0002019_abnormal_tumor_incidence1.43593193
26MP0003718_maternal_effect1.41542427
27MP0002210_abnormal_sex_determination1.38622862
28MP0003567_abnormal_fetal_cardiomyocyte1.33844596
29MP0002080_prenatal_lethality1.33108547
30MP0009333_abnormal_splenocyte_physiolog1.31145705
31MP0002697_abnormal_eye_size1.29046479
32MP0003984_embryonic_growth_retardation1.28249194
33MP0005397_hematopoietic_system_phenotyp1.26952204
34MP0001545_abnormal_hematopoietic_system1.26952204
35MP0002085_abnormal_embryonic_tissue1.26906122
36MP0003763_abnormal_thymus_physiology1.24546065
37MP0002088_abnormal_embryonic_growth/wei1.23149607
38MP0008789_abnormal_olfactory_epithelium1.20560673
39MP0000703_abnormal_thymus_morphology1.17770549
40MP0001145_abnormal_male_reproductive1.17764928
41MP0003890_abnormal_embryonic-extraembry1.17564536
42MP0003121_genomic_imprinting1.16951971
43MP0006035_abnormal_mitochondrial_morpho1.15692535
44MP0002398_abnormal_bone_marrow1.15286914
45MP0010352_gastrointestinal_tract_polyps1.15212052
46MP0001529_abnormal_vocalization1.15082545
47MP0001929_abnormal_gametogenesis1.14254339
48MP0003315_abnormal_perineum_morphology1.11203090
49MP0002086_abnormal_extraembryonic_tissu1.09978021
50MP0002233_abnormal_nose_morphology1.08621839
51MP0002102_abnormal_ear_morphology1.06957066
52MP0002084_abnormal_developmental_patter1.05339512
53MP0002722_abnormal_immune_system1.04650225
54MP0002160_abnormal_reproductive_system1.04570925
55MP0006072_abnormal_retinal_apoptosis1.03531507
56MP0004197_abnormal_fetal_growth/weight/1.02522581
57MP0000653_abnormal_sex_gland1.01854467
58MP0009379_abnormal_foot_pigmentation1.00967422
59MP0001119_abnormal_female_reproductive1.00068861
60MP0002132_abnormal_respiratory_system0.99941117
61MP0000689_abnormal_spleen_morphology0.98855963
62MP0002095_abnormal_skin_pigmentation0.96872302
63MP0000566_synostosis0.95552424
64MP0004147_increased_porphyrin_level0.95007874
65MP0005174_abnormal_tail_pigmentation0.94526630
66MP0001293_anophthalmia0.94206186
67MP0001346_abnormal_lacrimal_gland0.93889784
68MP0005389_reproductive_system_phenotype0.93370896
69MP0000049_abnormal_middle_ear0.90126828
70MP0002429_abnormal_blood_cell0.89287073
71MP0002092_abnormal_eye_morphology0.89081177
72MP0006036_abnormal_mitochondrial_physio0.88745020
73MP0005499_abnormal_olfactory_system0.87317102
74MP0005394_taste/olfaction_phenotype0.87317102
75MP0003119_abnormal_digestive_system0.85553902
76MP0006054_spinal_hemorrhage0.85503775
77MP0000858_altered_metastatic_potential0.84069846
78MP0002234_abnormal_pharynx_morphology0.83402937
79MP0001188_hyperpigmentation0.83027421
80MP0000428_abnormal_craniofacial_morphol0.82187686
81MP0000015_abnormal_ear_pigmentation0.81701517
82MP0003755_abnormal_palate_morphology0.79832389
83MP0003861_abnormal_nervous_system0.79803235
84MP0003941_abnormal_skin_development0.78450563
85MP0009697_abnormal_copulation0.78294180
86MP0000716_abnormal_immune_system0.77632660
87MP0005076_abnormal_cell_differentiation0.76360263
88MP0001835_abnormal_antigen_presentation0.73267787
89MP0000579_abnormal_nail_morphology0.70947523
90MP0000647_abnormal_sebaceous_gland0.69955562
91MP0003136_yellow_coat_color0.69166906
92MP0005395_other_phenotype0.68563774
93MP0003937_abnormal_limbs/digits/tail_de0.68219018
94MP0002163_abnormal_gland_morphology0.68195068
95MP0001919_abnormal_reproductive_system0.68128205
96MP0005391_vision/eye_phenotype0.68111453
97MP0008995_early_reproductive_senescence0.67965534
98MP0002420_abnormal_adaptive_immunity0.66528875
99MP0005384_cellular_phenotype0.66399639
100MP0002111_abnormal_tail_morphology0.66277819
101MP0002938_white_spotting0.66253564
102MP0000537_abnormal_urethra_morphology0.65683034
103MP0001819_abnormal_immune_cell0.65369834
104MP0003186_abnormal_redox_activity0.64916563
105MP0000465_gastrointestinal_hemorrhage0.64421504
106MP0005621_abnormal_cell_physiology0.63779131
107MP0005408_hypopigmentation0.63340398
108MP0001800_abnormal_humoral_immune0.63077095
109MP0005075_abnormal_melanosome_morpholog0.62619313
110MP0003935_abnormal_craniofacial_develop0.62435578
111MP0003698_abnormal_male_reproductive0.62294496
112MP0001186_pigmentation_phenotype0.61332706
113MP0002075_abnormal_coat/hair_pigmentati0.61043108
114MP0002452_abnormal_antigen_presenting0.60956714
115MP0010030_abnormal_orbit_morphology0.60536324
116MP0009672_abnormal_birth_weight0.59313282
117MP0004133_heterotaxia0.58053748
118MP0005671_abnormal_response_to0.57720893
119MP0000432_abnormal_head_morphology0.56831690
120MP0001286_abnormal_eye_development0.56760694
121MP0002751_abnormal_autonomic_nervous0.56599987
122MP0000358_abnormal_cell_content/0.55994407
123MP0002405_respiratory_system_inflammati0.55567995
124MP0000631_abnormal_neuroendocrine_gland0.54931228
125MP0000762_abnormal_tongue_morphology0.54432470
126MP0002009_preneoplasia0.53882847
127MP0009278_abnormal_bone_marrow0.53225915
128MP0000372_irregular_coat_pigmentation0.52389690
129MP0009703_decreased_birth_body0.51396671
130MP0002282_abnormal_trachea_morphology0.50551345
131MP0001881_abnormal_mammary_gland0.50444803
132MP0002161_abnormal_fertility/fecundity0.49517843
133MP0003699_abnormal_female_reproductive0.49300227

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)6.06338429
2Chromosomal breakage induced by crosslinking agents (HP:0003221)6.03125492
3Birth length less than 3rd percentile (HP:0003561)5.84151733
4Reticulocytopenia (HP:0001896)4.39990681
5Abnormality of chromosome stability (HP:0003220)4.21846281
6Meckel diverticulum (HP:0002245)4.21101396
7Abnormality of the preputium (HP:0100587)4.19637988
8Abnormality of the ileum (HP:0001549)4.01072912
9Aplasia/Hypoplasia of the uvula (HP:0010293)4.00425108
10Breast hypoplasia (HP:0003187)3.89322357
11Abnormal number of erythroid precursors (HP:0012131)3.61402870
12Abnormality of cells of the erythroid lineage (HP:0012130)3.58361589
13Patellar aplasia (HP:0006443)3.48316018
14Small intestinal stenosis (HP:0012848)3.35308023
15Duodenal stenosis (HP:0100867)3.35308023
16Aplasia/Hypoplasia of the patella (HP:0006498)3.25148316
17Duplicated collecting system (HP:0000081)3.22884997
18Aplastic anemia (HP:0001915)3.16961838
19Myelodysplasia (HP:0002863)3.15672825
20Oral leukoplakia (HP:0002745)3.08603191
21Impulsivity (HP:0100710)3.05470539
22Bone marrow hypocellularity (HP:0005528)3.02204937
23Cortical dysplasia (HP:0002539)2.97091511
2411 pairs of ribs (HP:0000878)2.94313024
25Abnormality of the renal collecting system (HP:0004742)2.90422278
26Medulloblastoma (HP:0002885)2.85515479
27Absent thumb (HP:0009777)2.84021458
28Ectopic kidney (HP:0000086)2.83546649
29Clubbing of toes (HP:0100760)2.78925352
30Colon cancer (HP:0003003)2.75256998
31Absent radius (HP:0003974)2.72371227
32Abnormality of the carotid arteries (HP:0005344)2.69878911
33Selective tooth agenesis (HP:0001592)2.69256335
34Nephroblastoma (Wilms tumor) (HP:0002667)2.69016061
35Abnormality of the duodenum (HP:0002246)2.67518490
36Sloping forehead (HP:0000340)2.64182749
37Abnormality of DNA repair (HP:0003254)2.61090288
38Aplasia involving forearm bones (HP:0009822)2.57023175
39Absent forearm bone (HP:0003953)2.57023175
40Agnosia (HP:0010524)2.54870873
41Abnormal lung lobation (HP:0002101)2.54653008
42Pallor (HP:0000980)2.53650797
43Acute necrotizing encephalopathy (HP:0006965)2.52994589
44Triphalangeal thumb (HP:0001199)2.51845669
45Embryonal renal neoplasm (HP:0011794)2.49571918
46Abnormality of the anterior horn cell (HP:0006802)2.48464429
47Degeneration of anterior horn cells (HP:0002398)2.48464429
48Premature graying of hair (HP:0002216)2.48227478
49Rough bone trabeculation (HP:0100670)2.46135901
50Tracheoesophageal fistula (HP:0002575)2.44670147
51Increased hepatocellular lipid droplets (HP:0006565)2.43547962
52Short thumb (HP:0009778)2.40764848
53Horseshoe kidney (HP:0000085)2.38264894
54Acute encephalopathy (HP:0006846)2.34368373
55Macrocytic anemia (HP:0001972)2.31906838
56Carpal bone hypoplasia (HP:0001498)2.31561474
57Abnormal mitochondria in muscle tissue (HP:0008316)2.27997049
58Microretrognathia (HP:0000308)2.25390223
59Supernumerary spleens (HP:0009799)2.24760269
60Septo-optic dysplasia (HP:0100842)2.24544847
61Abnormal number of incisors (HP:0011064)2.22871350
62Neoplasm of the colon (HP:0100273)2.21567407
63Neoplasm of the pancreas (HP:0002894)2.20499115
64Pancytopenia (HP:0001876)2.13870800
65Lipid accumulation in hepatocytes (HP:0006561)2.11484661
66Multiple enchondromatosis (HP:0005701)2.10325450
67Cleft eyelid (HP:0000625)2.10246929
68Duplication of thumb phalanx (HP:0009942)2.09071343
69Hypoplasia of the capital femoral epiphysis (HP:0003090)2.08050393
70Volvulus (HP:0002580)2.07163583
71Increased nuchal translucency (HP:0010880)2.06240674
72Abnormality of the heme biosynthetic pathway (HP:0010472)2.05988575
73Slender long bone (HP:0003100)2.05323903
74Cellular immunodeficiency (HP:0005374)2.03972299
75Lymphoma (HP:0002665)2.02687665
76Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02235837
77Atresia of the external auditory canal (HP:0000413)2.01538531
78Absent septum pellucidum (HP:0001331)2.01250804
79Increased CSF lactate (HP:0002490)1.99516979
80Abnormality of cochlea (HP:0000375)1.99156850
81Aplasia/Hypoplasia of the earlobes (HP:0009906)1.98152889
82Cafe-au-lait spot (HP:0000957)1.97994417
83Abnormality of methionine metabolism (HP:0010901)1.97875015
84Abnormality of the labia minora (HP:0012880)1.97480437
85Glioma (HP:0009733)1.95826145
86Embryonal neoplasm (HP:0002898)1.95097111
87Microvesicular hepatic steatosis (HP:0001414)1.94450311
88Cerebral edema (HP:0002181)1.93829453
89Abnormal spermatogenesis (HP:0008669)1.93517076
90Abnormality of the septum pellucidum (HP:0007375)1.93446173
91Mitochondrial inheritance (HP:0001427)1.93204219
92Progressive macrocephaly (HP:0004481)1.91912405
93Megaloblastic anemia (HP:0001889)1.91372499
94Rhabdomyosarcoma (HP:0002859)1.90354252
95High pitched voice (HP:0001620)1.90231221
96Facial hemangioma (HP:0000329)1.89287424
97Thrombocytosis (HP:0001894)1.88548164
98Type I transferrin isoform profile (HP:0003642)1.87676139
99Prominent nose (HP:0000448)1.86963693
100Oligodactyly (hands) (HP:0001180)1.85011343
101Hypoplastic pelvis (HP:0008839)1.84862964
102IgM deficiency (HP:0002850)1.84834645
103Ureteral duplication (HP:0000073)1.84067720
104Increased serum pyruvate (HP:0003542)1.83410023
105Arteriovenous malformation (HP:0100026)1.83085148
106Abnormality of pyrimidine metabolism (HP:0004353)1.81367956
107Leukopenia (HP:0001882)1.80951071
108Asplenia (HP:0001746)1.80720064
109Squamous cell carcinoma (HP:0002860)1.79249491
110Abnormal trabecular bone morphology (HP:0100671)1.78736141
111Abnormality of glycolysis (HP:0004366)1.78175484
112Microtia (HP:0008551)1.75883312
113Ependymoma (HP:0002888)1.74501163
114Hepatocellular necrosis (HP:0001404)1.74428247
115Abnormality of the fetal cardiovascular system (HP:0010948)1.73823261
116Abnormal umbilical cord blood vessels (HP:0011403)1.73823261
117Single umbilical artery (HP:0001195)1.73823261
118Optic nerve coloboma (HP:0000588)1.73728387
119Acute myeloid leukemia (HP:0004808)1.71978348
120Abnormality of reticulocytes (HP:0004312)1.71105631
121Aplasia/Hypoplasia of the sternum (HP:0006714)1.70731733
122Hypoplasia of the pons (HP:0012110)1.69834121
123Cerebral hypomyelination (HP:0006808)1.68992849
124Hypoplasia of the radius (HP:0002984)1.68208235
125Facial cleft (HP:0002006)1.67947866
126Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67941518
127Morphological abnormality of the inner ear (HP:0011390)1.67926972
128Prostate neoplasm (HP:0100787)1.67544595
129Hypopigmented skin patches (HP:0001053)1.66725112
130Choanal atresia (HP:0000453)1.66683660
131Secondary amenorrhea (HP:0000869)1.65651651
132Pancreatic islet-cell hyperplasia (HP:0004510)1.65331702
133Short middle phalanx of the 5th finger (HP:0004220)1.64279069
134Proximal placement of thumb (HP:0009623)1.64041938
135Ovarian neoplasm (HP:0100615)1.63749472
136Abnormality of the pons (HP:0007361)1.62506299
137Median cleft lip (HP:0000161)1.60004127
138Intestinal atresia (HP:0011100)1.58846301

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.86297407
2WEE14.54492776
3BUB14.29581575
4NEK23.00277813
5SRPK12.86573275
6PLK42.83662294
7VRK22.80598889
8EIF2AK12.70326511
9TTK2.69375573
10BRSK22.61856533
11STK162.36671695
12PLK12.28463516
13VRK12.10037994
14MKNK12.04871054
15ATR1.98855176
16NEK11.98763888
17TLK11.98566242
18AURKB1.94657009
19CCNB11.94569525
20EIF2AK31.94422994
21NME21.94088292
22ACVR1B1.92561262
23ZAK1.91151008
24PASK1.82955185
25BRSK11.79102991
26MKNK21.78239594
27CDK71.76783173
28CHEK21.67767324
29TAF11.66555224
30PLK31.63500562
31DYRK31.52350772
32TSSK61.46091226
33CDK41.41940564
34STK41.34099921
35EIF2AK21.32598651
36AURKA1.32520308
37MST41.31572617
38PNCK1.29902215
39RPS6KA41.24036391
40CHEK11.23438321
41NME11.21207344
42CDK81.18158582
43CLK11.15975705
44MAP3K81.13024954
45TRIM281.09707579
46IRAK41.06442279
47SCYL21.03459253
48TESK21.02047592
49ATM0.98702718
50STK100.97722977
51PIM10.93583501
52RPS6KB20.92849707
53BMPR1B0.87753890
54CDK20.81870755
55TNIK0.80796207
56MAP4K10.80537615
57BRAF0.80190038
58PBK0.77766270
59CDK120.77028957
60BRD40.76512933
61CDK10.71006553
62PDK20.70934224
63CSNK2A10.70360268
64PIM20.70221666
65TEC0.69623662
66MELK0.67563594
67WNK30.66560108
68TXK0.65868735
69PLK20.63901293
70PAK40.63217881
71BLK0.62418015
72CSNK2A20.61137040
73TGFBR10.60755283
74CDK60.54812999
75BTK0.53481795
76YES10.52961663
77ERBB40.52699921
78RPS6KA50.52425206
79PAK10.52305157
80MAP2K30.49347132
81LATS10.44953583
82EPHA20.42761223
83CSNK1E0.42550415
84PRKCI0.42178684
85NEK90.41652477
86MAP3K100.40434558
87CDK180.39449788
88CDK150.38571714
89ERBB30.38019366
90CDK11A0.37525420
91KDR0.35874286
92FGFR10.34435056
93STK30.33476197
94CDK140.33081276
95SMG10.32638047
96LYN0.32579382
97PRKDC0.32429567
98CSNK1G10.31576657
99CDK90.30936796
100TAOK20.30720669
101ALK0.30247292
102KIT0.27552828
103IRAK30.27421192
104CDK30.27359924
105JAK30.26727951
106CSF1R0.25852127
107MAPK140.24712797
108STK38L0.24481284
109AKT20.24442881
110LATS20.23011715
111AKT10.21868643
112EEF2K0.21209451
113FLT30.19980254
114DMPK0.19752661
115MAP3K110.19614845
116ZAP700.19606098
117TESK10.18419721
118RPS6KB10.18313930
119MET0.18013080
120BCR0.17732690
121MARK30.17164798
122RPS6KC10.16903583
123RPS6KL10.16903583
124NUAK10.16300794
125STK240.16199410
126RPS6KA60.15986448
127RAF10.15913546
128ABL20.15648942
129GSK3B0.15442853
130MAPKAPK50.14872241
131DYRK20.14220934

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.88366908
2Mismatch repair_Homo sapiens_hsa034304.81529083
3Homologous recombination_Homo sapiens_hsa034403.74911410
4Base excision repair_Homo sapiens_hsa034103.41463368
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.22908320
6Spliceosome_Homo sapiens_hsa030403.09227835
7Fanconi anemia pathway_Homo sapiens_hsa034603.08822512
8Nucleotide excision repair_Homo sapiens_hsa034203.07851673
9RNA polymerase_Homo sapiens_hsa030203.01337734
10Cell cycle_Homo sapiens_hsa041102.99388165
11Ribosome_Homo sapiens_hsa030102.97759663
12Proteasome_Homo sapiens_hsa030502.71120107
13RNA transport_Homo sapiens_hsa030132.69055395
14Pyrimidine metabolism_Homo sapiens_hsa002402.62027275
15Non-homologous end-joining_Homo sapiens_hsa034502.56286045
16One carbon pool by folate_Homo sapiens_hsa006702.48533556
17Basal transcription factors_Homo sapiens_hsa030221.95663953
18RNA degradation_Homo sapiens_hsa030181.87039625
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85327518
20p53 signaling pathway_Homo sapiens_hsa041151.69433727
21Oxidative phosphorylation_Homo sapiens_hsa001901.67552846
22mRNA surveillance pathway_Homo sapiens_hsa030151.56258243
23Purine metabolism_Homo sapiens_hsa002301.43186792
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36724939
25Systemic lupus erythematosus_Homo sapiens_hsa053221.33196803
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26988051
27Pyruvate metabolism_Homo sapiens_hsa006201.24490516
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16728290
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16457160
30Epstein-Barr virus infection_Homo sapiens_hsa051691.05850437
31Propanoate metabolism_Homo sapiens_hsa006401.04071996
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01708561
33Herpes simplex infection_Homo sapiens_hsa051680.99915122
34Steroid biosynthesis_Homo sapiens_hsa001000.95705945
35Oocyte meiosis_Homo sapiens_hsa041140.92749897
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91604689
37Alzheimers disease_Homo sapiens_hsa050100.90450104
38Vitamin B6 metabolism_Homo sapiens_hsa007500.88949767
39Carbon metabolism_Homo sapiens_hsa012000.86199637
40Antigen processing and presentation_Homo sapiens_hsa046120.85747784
41Viral carcinogenesis_Homo sapiens_hsa052030.82240938
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82199471
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82069640
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80333723
45Fatty acid elongation_Homo sapiens_hsa000620.78981630
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73262449
47HTLV-I infection_Homo sapiens_hsa051660.70477439
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68223625
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67346044
50Primary immunodeficiency_Homo sapiens_hsa053400.67278879
51Protein export_Homo sapiens_hsa030600.66902627
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.63559727
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62475870
54MicroRNAs in cancer_Homo sapiens_hsa052060.58389465
55Pentose phosphate pathway_Homo sapiens_hsa000300.56001903
56Selenocompound metabolism_Homo sapiens_hsa004500.55308467
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54820868
58Folate biosynthesis_Homo sapiens_hsa007900.54181604
59Small cell lung cancer_Homo sapiens_hsa052220.53425103
60Measles_Homo sapiens_hsa051620.52817744
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51110722
62N-Glycan biosynthesis_Homo sapiens_hsa005100.50563881
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48129575
64Huntingtons disease_Homo sapiens_hsa050160.48055870
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.48022936
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47999923
67Glutathione metabolism_Homo sapiens_hsa004800.46970634
68Legionellosis_Homo sapiens_hsa051340.45375287
69Apoptosis_Homo sapiens_hsa042100.44467603
70Alcoholism_Homo sapiens_hsa050340.44435326
71Hepatitis B_Homo sapiens_hsa051610.40938723
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.40890651
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39458235
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.38805419
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.38602767
76Hedgehog signaling pathway_Homo sapiens_hsa043400.38300371
77Hematopoietic cell lineage_Homo sapiens_hsa046400.37033108
78Cardiac muscle contraction_Homo sapiens_hsa042600.35021655
79Wnt signaling pathway_Homo sapiens_hsa043100.33130531
80Arachidonic acid metabolism_Homo sapiens_hsa005900.31854500
81Thyroid cancer_Homo sapiens_hsa052160.30739954
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29120766
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27245575
84Influenza A_Homo sapiens_hsa051640.27222284
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27033097
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25963500
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25513287
88Vitamin digestion and absorption_Homo sapiens_hsa049770.24426243
89Fatty acid metabolism_Homo sapiens_hsa012120.24020751
90Notch signaling pathway_Homo sapiens_hsa043300.22961441
91Allograft rejection_Homo sapiens_hsa053300.22443655
92Asthma_Homo sapiens_hsa053100.22344910
93Biosynthesis of amino acids_Homo sapiens_hsa012300.22187839
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21825540
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21798949
96Autoimmune thyroid disease_Homo sapiens_hsa053200.21585605
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21433599
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21392428
99Graft-versus-host disease_Homo sapiens_hsa053320.21363818
100Adherens junction_Homo sapiens_hsa045200.20868580
101Sulfur relay system_Homo sapiens_hsa041220.20189581
102Shigellosis_Homo sapiens_hsa051310.19839455
103Colorectal cancer_Homo sapiens_hsa052100.19697719
104TGF-beta signaling pathway_Homo sapiens_hsa043500.18993468
105Viral myocarditis_Homo sapiens_hsa054160.18880355
106Renin-angiotensin system_Homo sapiens_hsa046140.18586275
107Basal cell carcinoma_Homo sapiens_hsa052170.18370400
108Metabolic pathways_Homo sapiens_hsa011000.17905297
109Parkinsons disease_Homo sapiens_hsa050120.17812001
110Arginine and proline metabolism_Homo sapiens_hsa003300.17027695
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16308806
112Leishmaniasis_Homo sapiens_hsa051400.15745840
113Pathways in cancer_Homo sapiens_hsa052000.15659822
114Prostate cancer_Homo sapiens_hsa052150.14993933
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13713550
116Chronic myeloid leukemia_Homo sapiens_hsa052200.13413227
117Other glycan degradation_Homo sapiens_hsa005110.13018270
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11031220
119Fatty acid degradation_Homo sapiens_hsa000710.10281985
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.10217228
121Butanoate metabolism_Homo sapiens_hsa006500.09494460
122Melanoma_Homo sapiens_hsa052180.09057068
123Hippo signaling pathway_Homo sapiens_hsa043900.08389115
124Galactose metabolism_Homo sapiens_hsa000520.07177770
125Lysine degradation_Homo sapiens_hsa003100.07125652
126Peroxisome_Homo sapiens_hsa041460.07061024
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.06323573
128Pancreatic cancer_Homo sapiens_hsa052120.05464896
129Regulation of autophagy_Homo sapiens_hsa041400.05274124
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.05096031
131beta-Alanine metabolism_Homo sapiens_hsa004100.02222401
132Olfactory transduction_Homo sapiens_hsa047400.01783705
133Bladder cancer_Homo sapiens_hsa052190.00550092
134Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.00293291

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