ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	adaptation of signaling pathway (GO:0023058)	5.29661603
2	vitamin transmembrane transport (GO:0035461)	5.01525218
3	intestinal epithelial cell development (GO:0060576)	4.89256773
4	protein K48-linked deubiquitination (GO:0071108)	4.58131219
5	respiratory chain complex IV assembly (GO:0008535)	4.41736271
6	negative regulation of hormone biosynthetic process (GO:0032353)	4.21502803
7	neuromuscular synaptic transmission (GO:0007274)	4.18013169
8	negative regulation of DNA-dependent DNA replication (GO:2000104)	4.09871041
9	protein prenylation (GO:0018342)	4.06557974
10	prenylation (GO:0097354)	4.06557974
11	positive regulation by host of viral transcription (GO:0043923)	3.83339795
12	negative regulation of DNA repair (GO:0045738)	3.81897657
13	protein K63-linked deubiquitination (GO:0070536)	3.67938169
14	kynurenine metabolic process (GO:0070189)	3.67699256
15	eyelid development in camera-type eye (GO:0061029)	3.62956158
16	somite development (GO:0061053)	3.62824189
17	regulation of glycogen (starch) synthase activity (GO:2000465)	3.60447916
18	cellular ketone body metabolic process (GO:0046950)	3.59807149
19	protein localization to cytoskeleton (GO:0044380)	3.58685223
20	presynaptic membrane assembly (GO:0097105)	3.56598197
21	phosphatidylcholine biosynthetic process (GO:0006656)	3.55400265
22	negative regulation of Ras GTPase activity (GO:0034261)	3.47043211
23	indole-containing compound catabolic process (GO:0042436)	3.43961629
24	indolalkylamine catabolic process (GO:0046218)	3.43961629
25	tryptophan catabolic process (GO:0006569)	3.43961629
26	labyrinthine layer development (GO:0060711)	3.39953035
27	cytochrome complex assembly (GO:0017004)	3.38286790
28	protein localization to microtubule cytoskeleton (GO:0072698)	3.37951201
29	negative regulation of hormone metabolic process (GO:0032351)	3.34861226
30	signal peptide processing (GO:0006465)	3.34246123
31	ketone body metabolic process (GO:1902224)	3.26502104
32	neurotransmitter metabolic process (GO:0042133)	3.25272074
33	negative regulation of systemic arterial blood pressure (GO:0003085)	3.25037092
34	mechanosensory behavior (GO:0007638)	3.22752663
35	activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)	3.19263041
36	ventricular septum development (GO:0003281)	3.16566114
37	behavioral response to nicotine (GO:0035095)	3.12384794
38	skeletal muscle tissue regeneration (GO:0043403)	3.12109191
39	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.09707174
40	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.09707174
41	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.08195711
42	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.08195711
43	regulation of translation, ncRNA-mediated (GO:0045974)	3.08195711
44	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	3.05772861
45	regulation of RIG-I signaling pathway (GO:0039535)	3.05710884
46	microtubule nucleation (GO:0007020)	3.02865838
47	artery development (GO:0060840)	3.01963111
48	protein K11-linked deubiquitination (GO:0035871)	3.01564356
49	neurotransmitter biosynthetic process (GO:0042136)	3.00647608
50	pancreas development (GO:0031016)	2.98237656
51	limb development (GO:0060173)	2.95803143
52	appendage development (GO:0048736)	2.95803143
53	modulation by host of symbiont transcription (GO:0052472)	2.95507772
54	modulation by host of viral transcription (GO:0043921)	2.95507772
55	modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)	2.95285674
56	cell proliferation in forebrain (GO:0021846)	2.92953178
57	tryptophan metabolic process (GO:0006568)	2.91306608
58	spinal cord motor neuron differentiation (GO:0021522)	2.89963215
59	regulation of establishment of cell polarity (GO:2000114)	2.89328085
60	indolalkylamine metabolic process (GO:0006586)	2.87350118
61	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.85354485
62	organ formation (GO:0048645)	2.80936522
63	centrosome duplication (GO:0051298)	2.80814633
64	nonmotile primary cilium assembly (GO:0035058)	2.80409189
65	regulation of cilium movement (GO:0003352)	2.79599618
66	meiotic chromosome segregation (GO:0045132)	2.79530438
67	attachment of spindle microtubules to kinetochore (GO:0008608)	2.79306993
68	head development (GO:0060322)	2.79228049
69	tachykinin receptor signaling pathway (GO:0007217)	2.79023788
70	presynaptic membrane organization (GO:0097090)	2.78906513
71	cellular response to leptin stimulus (GO:0044320)	2.78290832
72	negative regulation of dendrite morphogenesis (GO:0050774)	2.75842219
73	endocrine pancreas development (GO:0031018)	2.74993107
74	negative regulation of membrane potential (GO:0045837)	2.74548852
75	lung epithelium development (GO:0060428)	2.73834592
76	somite rostral/caudal axis specification (GO:0032525)	2.70426365
77	negative regulation of glial cell differentiation (GO:0045686)	2.68567767
78	L-fucose catabolic process (GO:0042355)	2.67328844
79	fucose catabolic process (GO:0019317)	2.67328844
80	L-fucose metabolic process (GO:0042354)	2.67328844
81	negative regulation by host of viral transcription (GO:0043922)	2.67293938
82	negative regulation of cell aging (GO:0090344)	2.66419049
83	ectodermal placode formation (GO:0060788)	2.63367088
84	regulation of ruffle assembly (GO:1900027)	2.62887188
85	microtubule anchoring (GO:0034453)	2.60524882
86	type B pancreatic cell development (GO:0003323)	2.60499485
87	primitive streak formation (GO:0090009)	2.60448572
88	auditory behavior (GO:0031223)	2.58844194
89	retina layer formation (GO:0010842)	2.58262401
90	histone H3-K4 trimethylation (GO:0080182)	2.57968034
91	regulation of pigment cell differentiation (GO:0050932)	2.54811756
92	regulation of centriole replication (GO:0046599)	2.54600127
93	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.52616222
94	dopamine transport (GO:0015872)	2.52532419
95	histone H3-K9 modification (GO:0061647)	2.52172375
96	telencephalon development (GO:0021537)	2.52033918
97	embryonic axis specification (GO:0000578)	2.51309714
98	neural tube formation (GO:0001841)	2.50478205
99	sequestering of actin monomers (GO:0042989)	2.49364140
100	isotype switching (GO:0045190)	2.49230990

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA1_22025678_ChIP-Seq_K562_Human	3.60883233
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.11047726
3	VDR_22108803_ChIP-Seq_LS180_Human	2.95597204
4	EWS_26573619_Chip-Seq_HEK293_Human	2.78175601
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.71940375
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.66372897
7	FUS_26573619_Chip-Seq_HEK293_Human	2.64198035
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.63781230
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.62347729
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.47652738
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.42000932
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.27857714
13	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.26234108
14	ER_23166858_ChIP-Seq_MCF-7_Human	2.22204226
15	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.08369976
16	P300_19829295_ChIP-Seq_ESCs_Human	2.06589752
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.97113802
18	IGF1R_20145208_ChIP-Seq_DFB_Human	1.94517178
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.93793442
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.87378841
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.77166854
22	SMAD4_21799915_ChIP-Seq_A2780_Human	1.74973465
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.73370731
24	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.71621409
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.71321005
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.66257796
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.64800170
28	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.63108960
29	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.62869818
30	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.62357576
31	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.60810276
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.59094841
33	BCAT_22108803_ChIP-Seq_LS180_Human	1.59075127
34	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.56443158
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.56154669
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.56154669
37	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.54695041
38	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53437030
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.53437030
40	STAT3_23295773_ChIP-Seq_U87_Human	1.50258377
41	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.49353208
42	AR_21572438_ChIP-Seq_LNCaP_Human	1.47619358
43	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.46306667
44	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.44725976
45	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.44723687
46	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.43541187
47	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43328984
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43328984
49	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42861963
50	ELK1_19687146_ChIP-ChIP_HELA_Human	1.42576778
51	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.42467004
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.42165753
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.41984441
54	AR_25329375_ChIP-Seq_VCAP_Human	1.38876140
55	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.38616239
56	TCF4_23295773_ChIP-Seq_U87_Human	1.37871872
57	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.36805658
58	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.35894165
59	TP53_16413492_ChIP-PET_HCT116_Human	1.33420376
60	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.30659423
61	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29542318
62	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.27368704
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27189416
64	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.26390380
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.25541450
66	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.25414340
67	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.24660301
68	CDX2_22108803_ChIP-Seq_LS180_Human	1.21534608
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21268560
70	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21230659
71	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.20407695
72	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.19151892
73	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.18199738
74	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.16481931
75	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.16204132
76	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14872006
77	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.12003517
78	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.12000243
79	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.11737311
80	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.10292716
81	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.10152317
82	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.09736278
83	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.08851980
84	KDM2B_26808549_Chip-Seq_REH_Human	1.08786080
85	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.08531178
86	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.08474604
87	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.08474604
88	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.07775492
89	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.06201722
90	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05675484
91	TCF4_22108803_ChIP-Seq_LS180_Human	1.05017497
92	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.04318906
93	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.01859769
94	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.00905041
95	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.00874184
96	AHR_22903824_ChIP-Seq_MCF-7_Human	1.00772899
97	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.00565530
98	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.00358511
99	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99304149
100	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.98561550

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003283_abnormal_digestive_organ	8.12584894
2	MP0004142_abnormal_muscle_tone	3.53508279
3	MP0003136_yellow_coat_color	3.36241584
4	MP0002102_abnormal_ear_morphology	3.09397228
5	MP0003195_calcinosis	2.93795672
6	MP0008057_abnormal_DNA_replication	2.83576595
7	MP0000383_abnormal_hair_follicle	2.73102016
8	MP0004134_abnormal_chest_morphology	2.71515397
9	MP0003890_abnormal_embryonic-extraembry	2.69926597
10	MP0005187_abnormal_penis_morphology	2.52279943
11	MP0002163_abnormal_gland_morphology	2.50254884
12	MP0003880_abnormal_central_pattern	2.30523729
13	MP0008877_abnormal_DNA_methylation	2.29529858
14	MP0000569_abnormal_digit_pigmentation	2.25543642
15	MP0000372_irregular_coat_pigmentation	2.24818313
16	MP0008058_abnormal_DNA_repair	2.13270271
17	MP0010678_abnormal_skin_adnexa	1.90818314
18	MP0001485_abnormal_pinna_reflex	1.90659916
19	MP0002938_white_spotting	1.76715248
20	MP0000462_abnormal_digestive_system	1.76105309
21	MP0002751_abnormal_autonomic_nervous	1.68973953
22	MP0010094_abnormal_chromosome_stability	1.67902933
23	MP0003119_abnormal_digestive_system	1.67750952
24	MP0002108_abnormal_muscle_morphology	1.61887777
25	MP0005310_abnormal_salivary_gland	1.60243548
26	MP0005084_abnormal_gallbladder_morpholo	1.59338239
27	MP0005379_endocrine/exocrine_gland_phen	1.50055470
28	MP0008007_abnormal_cellular_replicative	1.43763060
29	MP0001529_abnormal_vocalization	1.40002274
30	MP0009780_abnormal_chondrocyte_physiolo	1.38011230
31	MP0004147_increased_porphyrin_level	1.36765817
32	MP0005503_abnormal_tendon_morphology	1.34885407
33	MP0002009_preneoplasia	1.34171332
34	MP0005377_hearing/vestibular/ear_phenot	1.31936393
35	MP0003878_abnormal_ear_physiology	1.31936393
36	MP0003937_abnormal_limbs/digits/tail_de	1.24729481
37	MP0005171_absent_coat_pigmentation	1.20568712
38	MP0001986_abnormal_taste_sensitivity	1.17093044
39	MP0002928_abnormal_bile_duct	1.12799685
40	MP0002166_altered_tumor_susceptibility	1.11420575
41	MP0000049_abnormal_middle_ear	1.09298936
42	MP0003787_abnormal_imprinting	1.09180828
43	MP0006276_abnormal_autonomic_nervous	1.08870781
44	MP0001293_anophthalmia	1.08377858
45	MP0004742_abnormal_vestibular_system	1.07371262
46	MP0002233_abnormal_nose_morphology	1.06847862
47	MP0001188_hyperpigmentation	1.05527177
48	MP0005386_behavior/neurological_phenoty	1.02347828
49	MP0004924_abnormal_behavior	1.02347828
50	MP0001486_abnormal_startle_reflex	1.00208810
51	MP0002272_abnormal_nervous_system	1.00202401
52	MP0009046_muscle_twitch	0.98110941
53	MP0002138_abnormal_hepatobiliary_system	0.95764632
54	MP0000427_abnormal_hair_cycle	0.95619003
55	MP0002160_abnormal_reproductive_system	0.91484082
56	MP0004381_abnormal_hair_follicle	0.91222581
57	MP0006072_abnormal_retinal_apoptosis	0.90872064
58	MP0001286_abnormal_eye_development	0.90656627
59	MP0010307_abnormal_tumor_latency	0.89698931
60	MP0000015_abnormal_ear_pigmentation	0.89635492
61	MP0004145_abnormal_muscle_electrophysio	0.89482874
62	MP0003077_abnormal_cell_cycle	0.87241349
63	MP0005408_hypopigmentation	0.86492255
64	MP0005551_abnormal_eye_electrophysiolog	0.85709003
65	MP0009053_abnormal_anal_canal	0.82922100
66	MP0010352_gastrointestinal_tract_polyps	0.82333784
67	MP0003045_fibrosis	0.81307221
68	MP0001440_abnormal_grooming_behavior	0.79296970
69	MP0000631_abnormal_neuroendocrine_gland	0.77909038
70	MP0005075_abnormal_melanosome_morpholog	0.77465417
71	MP0003646_muscle_fatigue	0.77243542
72	MP0004885_abnormal_endolymph	0.76991577
73	MP0000647_abnormal_sebaceous_gland	0.75989522
74	MP0005253_abnormal_eye_physiology	0.75778204
75	MP0004883_abnormal_blood_vessel	0.72743869
76	MP0002557_abnormal_social/conspecific_i	0.72315336
77	MP0005167_abnormal_blood-brain_barrier	0.69928373
78	MP0002184_abnormal_innervation	0.68168234
79	MP0002067_abnormal_sensory_capabilities	0.67914781
80	MP0003121_genomic_imprinting	0.67610435
81	MP0005220_abnormal_exocrine_pancreas	0.67477261
82	MP0002095_abnormal_skin_pigmentation	0.67176963
83	MP0004197_abnormal_fetal_growth/weight/	0.67153599
84	MP0008789_abnormal_olfactory_epithelium	0.66761294
85	MP0000778_abnormal_nervous_system	0.66446394
86	MP0009250_abnormal_appendicular_skeleto	0.65621225
87	MP0009745_abnormal_behavioral_response	0.64273766
88	MP0002653_abnormal_ependyma_morphology	0.63823481
89	MP0000538_abnormal_urinary_bladder	0.62081780
90	MP0005174_abnormal_tail_pigmentation	0.60968970
91	MP0001929_abnormal_gametogenesis	0.60819534
92	MP0002090_abnormal_vision	0.60315701
93	MP0002111_abnormal_tail_morphology	0.60308607
94	MP0002697_abnormal_eye_size	0.60050674
95	MP0003786_premature_aging	0.59965474
96	MP0008872_abnormal_physiological_respon	0.59806056
97	MP0003718_maternal_effect	0.59426643
98	MP0002282_abnormal_trachea_morphology	0.58244322
99	MP0009697_abnormal_copulation	0.57700527
100	MP0000955_abnormal_spinal_cord	0.57458794

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type 2 muscle fiber atrophy (HP:0003554)	5.64904572
2	Muscle fiber atrophy (HP:0100295)	4.52266258
3	Fatigable weakness (HP:0003473)	3.44959309
4	Abnormality of the neuromuscular junction (HP:0003398)	3.44959309
5	Bilateral microphthalmos (HP:0007633)	3.41586974
6	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.39528574
7	Abnormality of chromosome stability (HP:0003220)	3.35027542
8	Pancreatic cysts (HP:0001737)	3.29293860
9	Chromsome breakage (HP:0040012)	3.16353069
10	Genetic anticipation (HP:0003743)	3.16086602
11	Poor suck (HP:0002033)	3.04087576
12	Weak cry (HP:0001612)	2.97371442
13	Homocystinuria (HP:0002156)	2.86513302
14	Abnormality of homocysteine metabolism (HP:0010919)	2.86513302
15	Pancreatic fibrosis (HP:0100732)	2.84987077
16	Medulloblastoma (HP:0002885)	2.84035223
17	Rhabdomyosarcoma (HP:0002859)	2.83894095
18	Colon cancer (HP:0003003)	2.83268276
19	True hermaphroditism (HP:0010459)	2.80789057
20	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.78967553
21	Abnormal pancreas size (HP:0012094)	2.77846998
22	Generalized hypotonia (HP:0001290)	2.58876363
23	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.57502216
24	Ectopic kidney (HP:0000086)	2.57143488
25	Neoplasm of striated muscle (HP:0009728)	2.56546296
26	Duodenal stenosis (HP:0100867)	2.51723386
27	Small intestinal stenosis (HP:0012848)	2.51723386
28	Meckel diverticulum (HP:0002245)	2.47865964
29	Glioma (HP:0009733)	2.44170322
30	Increased circulating renin level (HP:0000848)	2.41017717
31	Abnormality of methionine metabolism (HP:0010901)	2.37040804
32	Medial flaring of the eyebrow (HP:0010747)	2.36056902
33	Abnormality of the duodenum (HP:0002246)	2.35517747
34	Abnormality of vitamin B metabolism (HP:0004340)	2.35185537
35	Birth length less than 3rd percentile (HP:0003561)	2.34235228
36	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.33256918
37	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.33256918
38	Abnormality of the ileum (HP:0001549)	2.26849944
39	Duplicated collecting system (HP:0000081)	2.21065557
40	Confusion (HP:0001289)	2.19826719
41	Metabolic alkalosis (HP:0200114)	2.19515286
42	Congenital primary aphakia (HP:0007707)	2.17462541
43	Abnormality of the renal collecting system (HP:0004742)	2.17418677
44	Clubbing of toes (HP:0100760)	2.15381740
45	Abnormality of the carotid arteries (HP:0005344)	2.12165885
46	Disproportionate short-trunk short stature (HP:0003521)	2.08053562
47	Gait imbalance (HP:0002141)	2.07742550
48	Abnormal rod and cone electroretinograms (HP:0008323)	2.07297582
49	Biliary tract neoplasm (HP:0100574)	2.07178501
50	Constricted visual fields (HP:0001133)	2.04053168
51	Volvulus (HP:0002580)	2.03875686
52	Abnormality of the preputium (HP:0100587)	2.01238161
53	Sloping forehead (HP:0000340)	2.00661453
54	Abnormality of secondary sexual hair (HP:0009888)	1.99948264
55	Abnormality of the axillary hair (HP:0100134)	1.99948264
56	Respiratory distress (HP:0002098)	1.97846694
57	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.97497967
58	Hypoplastic pelvis (HP:0008839)	1.97409552
59	Small hand (HP:0200055)	1.97094812
60	Neoplasm of the oral cavity (HP:0100649)	1.97001743
61	Tinnitus (HP:0000360)	1.96399888
62	Neurodegeneration (HP:0002180)	1.96091304
63	Abnormality of the nasal septum (HP:0000419)	1.95928007
64	Megaloblastic anemia (HP:0001889)	1.95772752
65	Triphalangeal thumb (HP:0001199)	1.94444196
66	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.93561414
67	Abnormality of midbrain morphology (HP:0002418)	1.93309824
68	Molar tooth sign on MRI (HP:0002419)	1.93309824
69	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.88119552
70	Astigmatism (HP:0000483)	1.87490423
71	Parakeratosis (HP:0001036)	1.87263377
72	Pheochromocytoma (HP:0002666)	1.83534505
73	Attenuation of retinal blood vessels (HP:0007843)	1.83527767
74	Furrowed tongue (HP:0000221)	1.82636014
75	Reticulocytopenia (HP:0001896)	1.82511980
76	Cystic liver disease (HP:0006706)	1.80144414
77	Keratoconus (HP:0000563)	1.79133624
78	Increased corneal curvature (HP:0100692)	1.79133624
79	Nephronophthisis (HP:0000090)	1.78118379
80	Long nose (HP:0003189)	1.74050018
81	Congenital sensorineural hearing impairment (HP:0008527)	1.73960577
82	Congenital, generalized hypertrichosis (HP:0004540)	1.72858072
83	Chronic hepatic failure (HP:0100626)	1.72505959
84	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.72060994
85	Cerebral hemorrhage (HP:0001342)	1.70162159
86	Poor coordination (HP:0002370)	1.69936785
87	Abnormality of the epiphyses of the hand (HP:0005924)	1.69310517
88	Concave nail (HP:0001598)	1.69134630
89	Oligohydramnios (HP:0001562)	1.69012979
90	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.68681876
91	Abnormality of DNA repair (HP:0003254)	1.68253170
92	Central scotoma (HP:0000603)	1.67161189
93	Intellectual disability, profound (HP:0002187)	1.66358440
94	Neuroendocrine neoplasm (HP:0100634)	1.66035650
95	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	1.65126096
96	Abnormality of the labia minora (HP:0012880)	1.64076327
97	Papillary thyroid carcinoma (HP:0002895)	1.64057715
98	Nephrogenic diabetes insipidus (HP:0009806)	1.64027973
99	Preaxial hand polydactyly (HP:0001177)	1.63553664
100	Hypokalemic alkalosis (HP:0001949)	1.63102790

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.53953744
2	SIK3	3.55917640
3	PDK2	3.45046727
4	MKNK2	2.73387015
5	TAOK3	2.52399545
6	ADRBK2	2.45474396
7	SIK2	2.39044996
8	BMPR1B	2.34727676
9	SIK1	2.34327170
10	MKNK1	2.11260191
11	TSSK6	2.07573166
12	STK38L	1.85539537
13	ACVR1B	1.80784394
14	BUB1	1.78784085
15	PASK	1.72187401
16	MARK3	1.71680324
17	NLK	1.69322412
18	TAF1	1.67062882
19	PIK3CG	1.65223989
20	NEK6	1.53999126
21	PRKCG	1.49590356
22	MAP3K9	1.46174680
23	TRIM28	1.43177477
24	PNCK	1.41139993
25	SGK2	1.37795625
26	CAMK1D	1.36410906
27	MST4	1.35886694
28	TNIK	1.32493449
29	PLK2	1.17556082
30	STK39	1.16488084
31	TGFBR1	1.13370004
32	CAMK1G	1.12022513
33	AKT3	1.10133560
34	PRKCE	1.09552158
35	NEK9	1.07594477
36	NEK1	1.05754655
37	STK38	0.97640549
38	PRKCH	0.95285733
39	PLK3	0.94712241
40	NUAK1	0.89630595
41	OXSR1	0.89422592
42	TYRO3	0.88829585
43	WEE1	0.87973862
44	MAP3K4	0.86191313
45	PIK3CA	0.86125398
46	BRSK2	0.84035407
47	KSR1	0.83379915
48	BRD4	0.82033918
49	VRK1	0.79917250
50	MAP3K2	0.77947638
51	MAPK15	0.76785002
52	ZAK	0.75372219
53	PLK4	0.75199637
54	GRK1	0.74331319
55	SGK494	0.69676160
56	SGK223	0.69676160
57	SGK3	0.69056004
58	MAP2K1	0.68845492
59	TEC	0.68494454
60	FGFR3	0.61710370
61	BMPR2	0.58929707
62	MAPK13	0.57893584
63	ADRBK1	0.57820418
64	PTK2B	0.56438645
65	ERBB3	0.54938945
66	PINK1	0.54278692
67	PAK3	0.54070509
68	PRKD2	0.53978120
69	STK4	0.53140153
70	PRKCZ	0.51426799
71	RPS6KA5	0.46256377
72	CAMK2A	0.45398104
73	WNK3	0.43814906
74	OBSCN	0.42289271
75	DMPK	0.42000790
76	MAP4K2	0.41736366
77	ERBB2	0.40865408
78	CASK	0.39792551
79	YES1	0.39718331
80	MELK	0.39545464
81	CAMK2G	0.37852023
82	CAMK4	0.37802473
83	CSNK1A1L	0.37483178
84	ATM	0.37228215
85	INSRR	0.35936007
86	RAF1	0.34262824
87	CSNK1G1	0.33451686
88	FGFR1	0.33216543
89	EPHB2	0.32663915
90	CSNK1A1	0.32157988
91	TIE1	0.31227770
92	CDK8	0.30610764
93	IKBKB	0.30556201
94	ATR	0.30105057
95	FLT3	0.29217610
96	PLK1	0.28711577
97	GSK3A	0.27694538
98	SGK1	0.27620175
99	FER	0.27601742
100	PDGFRB	0.25219445

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.21449044
2	Selenocompound metabolism_Homo sapiens_hsa00450	3.22445469
3	Fanconi anemia pathway_Homo sapiens_hsa03460	2.99854869
4	Caffeine metabolism_Homo sapiens_hsa00232	2.90096229
5	Non-homologous end-joining_Homo sapiens_hsa03450	2.89245801
6	Butanoate metabolism_Homo sapiens_hsa00650	2.72664962
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.60950693
8	Homologous recombination_Homo sapiens_hsa03440	2.57248833
9	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.46738196
10	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.38886916
11	Basal transcription factors_Homo sapiens_hsa03022	2.27618858
12	ABC transporters_Homo sapiens_hsa02010	2.08667789
13	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.07064682
14	Basal cell carcinoma_Homo sapiens_hsa05217	2.03204906
15	Nicotine addiction_Homo sapiens_hsa05033	1.89337568
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.87622058
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.81393925
18	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.73812886
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.72591660
20	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.70893168
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.64717219
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.59270046
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.57625795
24	Olfactory transduction_Homo sapiens_hsa04740	1.40774741
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.39636060
26	Taste transduction_Homo sapiens_hsa04742	1.34999485
27	RNA degradation_Homo sapiens_hsa03018	1.32742570
28	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.31286129
29	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.28258590
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.14023739
31	Renin-angiotensin system_Homo sapiens_hsa04614	1.13255171
32	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.05995305
33	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.04171867
34	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.03215037
35	Retinol metabolism_Homo sapiens_hsa00830	1.02970480
36	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.02876181
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.02012886
38	Fat digestion and absorption_Homo sapiens_hsa04975	0.98339574
39	Mismatch repair_Homo sapiens_hsa03430	0.92364901
40	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.91000534
41	Lysine degradation_Homo sapiens_hsa00310	0.90314217
42	Ether lipid metabolism_Homo sapiens_hsa00565	0.89711769
43	p53 signaling pathway_Homo sapiens_hsa04115	0.81955176
44	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.81758743
45	Cell cycle_Homo sapiens_hsa04110	0.81441269
46	Glycerolipid metabolism_Homo sapiens_hsa00561	0.80964548
47	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.80391007
48	Phototransduction_Homo sapiens_hsa04744	0.79630771
49	Peroxisome_Homo sapiens_hsa04146	0.78720763
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78526028
51	Alcoholism_Homo sapiens_hsa05034	0.78477600
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77916744
53	Melanoma_Homo sapiens_hsa05218	0.77753475
54	Cholinergic synapse_Homo sapiens_hsa04725	0.74790881
55	Long-term depression_Homo sapiens_hsa04730	0.69617062
56	Insulin secretion_Homo sapiens_hsa04911	0.69535135
57	Glutamatergic synapse_Homo sapiens_hsa04724	0.69258099
58	Propanoate metabolism_Homo sapiens_hsa00640	0.68171404
59	Histidine metabolism_Homo sapiens_hsa00340	0.67175102
60	Oxidative phosphorylation_Homo sapiens_hsa00190	0.65737212
61	Nucleotide excision repair_Homo sapiens_hsa03420	0.65043800
62	Type II diabetes mellitus_Homo sapiens_hsa04930	0.64865385
63	Ribosome_Homo sapiens_hsa03010	0.64511922
64	Proteasome_Homo sapiens_hsa03050	0.62494159
65	Parkinsons disease_Homo sapiens_hsa05012	0.57555387
66	Hippo signaling pathway_Homo sapiens_hsa04390	0.56871911
67	Wnt signaling pathway_Homo sapiens_hsa04310	0.55445338
68	Fatty acid degradation_Homo sapiens_hsa00071	0.55027810
69	Mineral absorption_Homo sapiens_hsa04978	0.54203775
70	Huntingtons disease_Homo sapiens_hsa05016	0.53006414
71	cAMP signaling pathway_Homo sapiens_hsa04024	0.49733897
72	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.49631392
73	RNA polymerase_Homo sapiens_hsa03020	0.48754737
74	Prolactin signaling pathway_Homo sapiens_hsa04917	0.47137343
75	Cocaine addiction_Homo sapiens_hsa05030	0.45238232
76	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.44483190
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43671846
78	GABAergic synapse_Homo sapiens_hsa04727	0.43297077
79	Regulation of autophagy_Homo sapiens_hsa04140	0.43072757
80	Prostate cancer_Homo sapiens_hsa05215	0.43070659
81	Colorectal cancer_Homo sapiens_hsa05210	0.42974189
82	Melanogenesis_Homo sapiens_hsa04916	0.42215660
83	Fatty acid elongation_Homo sapiens_hsa00062	0.42055549
84	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.41544841
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.38316760
86	Purine metabolism_Homo sapiens_hsa00230	0.38094814
87	Calcium signaling pathway_Homo sapiens_hsa04020	0.37724537
88	MicroRNAs in cancer_Homo sapiens_hsa05206	0.37719915
89	Alzheimers disease_Homo sapiens_hsa05010	0.36957899
90	FoxO signaling pathway_Homo sapiens_hsa04068	0.36014015
91	Serotonergic synapse_Homo sapiens_hsa04726	0.32950370
92	Circadian rhythm_Homo sapiens_hsa04710	0.32617039
93	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.32532898
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.30906775
95	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.30485284
96	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.30127749
97	RNA transport_Homo sapiens_hsa03013	0.29982775
98	Glutathione metabolism_Homo sapiens_hsa00480	0.27832738
99	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.27398137
100	Morphine addiction_Homo sapiens_hsa05032	0.26976804

RAD51AP1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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