RAD51AP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1meiotic cell cycle process (GO:1903046)9.20566109
2sister chromatid cohesion (GO:0007062)8.73285299
3reciprocal meiotic recombination (GO:0007131)7.70026764
4reciprocal DNA recombination (GO:0035825)7.70026764
5regulation of meiosis I (GO:0060631)7.23571103
6resolution of meiotic recombination intermediates (GO:0000712)6.53442224
7histone H3-K9 demethylation (GO:0033169)5.82185476
8meiotic chromosome segregation (GO:0045132)5.80538518
9COPI coating of Golgi vesicle (GO:0048205)5.51850838
10Golgi transport vesicle coating (GO:0048200)5.51850838
11gene silencing by RNA (GO:0031047)5.43556340
12histone H3-K36 demethylation (GO:0070544)5.38385906
13protein maturation by protein folding (GO:0022417)5.34702129
14endocrine pancreas development (GO:0031018)4.72519617
15regulation of meiotic cell cycle (GO:0051445)4.57128009
16female gamete generation (GO:0007292)4.46643211
17regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.46599806
18postsynaptic membrane organization (GO:0001941)4.45413904
19positive regulation of cellular response to oxidative stress (GO:1900409)4.41787468
20positive regulation of response to oxidative stress (GO:1902884)4.41787468
21mitotic sister chromatid cohesion (GO:0007064)4.37795220
22peptide hormone processing (GO:0016486)4.36407746
23presynaptic membrane assembly (GO:0097105)4.31725670
24detection of calcium ion (GO:0005513)4.28512653
25DNA biosynthetic process (GO:0071897)4.23756003
26startle response (GO:0001964)4.19772045
27DNA alkylation (GO:0006305)4.13150652
28DNA methylation (GO:0006306)4.13150652
29regulation of DNA endoreduplication (GO:0032875)4.12531076
30protein localization to chromosome (GO:0034502)4.06415534
31insulin secretion (GO:0030073)4.01747577
32regulation of type B pancreatic cell apoptotic process (GO:2000674)3.97767148
33reproductive system development (GO:0061458)3.95308612
34chromosome organization (GO:0051276)3.87018546
35positive regulation of insulin secretion (GO:0032024)3.86552042
36piRNA metabolic process (GO:0034587)3.84385459
37negative regulation of inclusion body assembly (GO:0090084)3.80172223
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.79303809
39regulation of insulin secretion (GO:0050796)3.78397105
40neuronal action potential propagation (GO:0019227)3.72645511
41signal peptide processing (GO:0006465)3.68621045
42ER overload response (GO:0006983)3.67802201
43regulation of transcription from RNA polymerase I promoter (GO:0006356)3.66858889
44histone H2A acetylation (GO:0043968)3.65384732
45presynaptic membrane organization (GO:0097090)3.64763294
46glandular epithelial cell differentiation (GO:0002067)3.59249782
47genitalia morphogenesis (GO:0035112)3.58254123
48acrosome assembly (GO:0001675)3.55344825
49meiotic cell cycle (GO:0051321)3.54815140
50negative regulation of gene silencing (GO:0060969)3.54051058
51regulation of penile erection (GO:0060405)3.52286499
52histone exchange (GO:0043486)3.51685003
53regulation of histone H3-K9 methylation (GO:0051570)3.51014926
54retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.47751189
55regulation of peptide hormone secretion (GO:0090276)3.47266437
56attachment of spindle microtubules to kinetochore (GO:0008608)3.43598767
57regulation of peptide secretion (GO:0002791)3.43414053
58negative regulation of insulin secretion (GO:0046676)3.41198192
59inner ear receptor cell development (GO:0060119)3.39461137
60synaptic transmission, glutamatergic (GO:0035249)3.37463056
61fertilization (GO:0009566)3.36714282
62protein localization to Golgi apparatus (GO:0034067)3.34936702
63spermatid development (GO:0007286)3.33601182
64regulation of synaptic vesicle exocytosis (GO:2000300)3.33485874
65glutamate receptor signaling pathway (GO:0007215)3.31373528
66negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)3.24839525
67regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.23891842
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.22953838
69COPII vesicle coating (GO:0048208)3.22638682
70maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.22198371
71regulation of synaptic vesicle transport (GO:1902803)3.20180932
72gene silencing (GO:0016458)3.18107472
73sequestering of metal ion (GO:0051238)3.17302641
74lactate metabolic process (GO:0006089)3.15899992
75ionotropic glutamate receptor signaling pathway (GO:0035235)3.15892401
76positive regulation of peptide hormone secretion (GO:0090277)3.12977149
77nuclear division (GO:0000280)3.12805160
78regulation of short-term neuronal synaptic plasticity (GO:0048172)3.12415760
79positive regulation of peptide secretion (GO:0002793)3.11138862
80histone lysine demethylation (GO:0070076)3.10524199
81type B pancreatic cell development (GO:0003323)3.08462990
82phosphorelay signal transduction system (GO:0000160)3.07773312
83regulation of hormone secretion (GO:0046883)3.06431946
84nitric oxide mediated signal transduction (GO:0007263)3.05679306
85positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.05362411
86DNA methylation involved in gamete generation (GO:0043046)3.04528276
87interkinetic nuclear migration (GO:0022027)3.03953978
88binding of sperm to zona pellucida (GO:0007339)3.03490898
89histone demethylation (GO:0016577)3.02449323
90epithelial cilium movement (GO:0003351)3.00401527
91proteasome assembly (GO:0043248)2.99985819
92mitotic spindle assembly checkpoint (GO:0007094)2.98649021
93regulation of microtubule-based movement (GO:0060632)2.98630548
94DNA packaging (GO:0006323)2.98310632
95DNA methylation or demethylation (GO:0044728)2.97075428
96negative regulation of peptide hormone secretion (GO:0090278)2.93583506
97eye photoreceptor cell differentiation (GO:0001754)2.92103939
98photoreceptor cell differentiation (GO:0046530)2.92103939
99positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.91631353
100neuron cell-cell adhesion (GO:0007158)2.91219785
101regulation of meiosis (GO:0040020)2.91184930
102neuron-neuron synaptic transmission (GO:0007270)2.91077732
103spindle assembly checkpoint (GO:0071173)2.90201127
104oogenesis (GO:0048477)2.89942622
105peptide hormone secretion (GO:0030072)2.89819511
106organelle fission (GO:0048285)2.89260759
107intraciliary transport (GO:0042073)2.87016074
108regulation of glucocorticoid secretion (GO:2000849)2.86028961
109negative regulation of meiosis (GO:0045835)2.85970966
110sex differentiation (GO:0007548)2.85289434
111gamete generation (GO:0007276)2.84427107
112regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.83481655
113synaptic vesicle docking involved in exocytosis (GO:0016081)2.81190033
114positive regulation of meiosis (GO:0045836)2.80878707
115negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.80665226
116negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.80665226
117negative regulation of mitotic sister chromatid segregation (GO:0033048)2.80665226
118negative regulation of mitotic sister chromatid separation (GO:2000816)2.80665226
119negative regulation of sister chromatid segregation (GO:0033046)2.80665226
120peptide secretion (GO:0002790)2.80614590
121male gamete generation (GO:0048232)2.80435159
122germ cell development (GO:0007281)2.80327389
123innervation (GO:0060384)2.80030319
124negative regulation of peptide secretion (GO:0002792)2.80017985
125spermatogenesis (GO:0007283)2.79790795
126mitotic spindle checkpoint (GO:0071174)2.79366579
127negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.79157094
128regulation of calcium ion-dependent exocytosis (GO:0017158)2.78586739
129protein dealkylation (GO:0008214)2.78254564
130protein demethylation (GO:0006482)2.78254564
131regulation of oxidative phosphorylation (GO:0002082)2.77529729
132synaptic vesicle endocytosis (GO:0048488)2.77100254
133toxin metabolic process (GO:0009404)2.76749883
134male meiosis (GO:0007140)2.76547739
135histone H4-K12 acetylation (GO:0043983)2.76286052
136embryonic body morphogenesis (GO:0010172)2.75153323
137calcium ion-dependent exocytosis (GO:0017156)2.74315460
138protein retention in ER lumen (GO:0006621)2.72624976
139positive regulation of vesicle fusion (GO:0031340)2.70268737
140regulation of peptide transport (GO:0090087)2.70088395
141positive regulation of exocytosis (GO:0045921)2.69159388
142positive regulation of ERBB signaling pathway (GO:1901186)2.69131110
143negative regulation of chromosome segregation (GO:0051985)2.68199159
144negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.67517507
145synaptic vesicle exocytosis (GO:0016079)2.67385711
146nonmotile primary cilium assembly (GO:0035058)2.67001822
147glandular epithelial cell development (GO:0002068)2.66574433
148nuclear pore complex assembly (GO:0051292)2.65080346
149vesicle coating (GO:0006901)2.65029040
150regulation of vesicle fusion (GO:0031338)2.64989058
151membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.64327935
152regulation of sensory perception (GO:0051931)2.63690740
153regulation of sensory perception of pain (GO:0051930)2.63690740
154negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.63378648
155negative regulation of synaptic transmission, GABAergic (GO:0032229)2.63337765
156regulation of hexokinase activity (GO:1903299)2.62693509
157regulation of glucokinase activity (GO:0033131)2.62693509
158adaptation of signaling pathway (GO:0023058)2.62686651
159chemosensory behavior (GO:0007635)2.61620790
160negative regulation of glycoprotein biosynthetic process (GO:0010561)2.60857276
161proline transport (GO:0015824)2.60672453
162negative regulation of adenylate cyclase activity (GO:0007194)2.60200267
163long term synaptic depression (GO:0060292)2.59909138
164protein targeting to Golgi (GO:0000042)2.57648323
165zinc ion transmembrane transport (GO:0071577)2.57144670
166cellular process involved in reproduction in multicellular organism (GO:0022412)2.56905862
167protein localization to synapse (GO:0035418)2.56699701
168regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.55382969
169calcium ion import (GO:0070509)2.55365158
170exocrine pancreas development (GO:0031017)2.54399962
171positive regulation of meiotic cell cycle (GO:0051446)2.53562624
172protein refolding (GO:0042026)2.52932193
173DNA replication-dependent nucleosome organization (GO:0034723)2.52698255
174DNA replication-dependent nucleosome assembly (GO:0006335)2.52698255
175spindle checkpoint (GO:0031577)2.52238871
176regulation of mitotic sister chromatid separation (GO:0010965)2.49587844
177regulation of mitotic sister chromatid segregation (GO:0033047)2.49587844
178regulation of sister chromatid segregation (GO:0033045)2.49587844
179macroautophagy (GO:0016236)2.48054114
180response to misfolded protein (GO:0051788)2.47630476
181positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)2.42903260
182regulation of mitotic metaphase/anaphase transition (GO:0030071)2.38349389
183regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.38349389
184regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)2.36693469
185sperm-egg recognition (GO:0035036)2.34022007
186DNA modification (GO:0006304)2.33678450
187synapsis (GO:0007129)19.4401609
188chromosome organization involved in meiosis (GO:0070192)16.9749929
189synaptonemal complex assembly (GO:0007130)16.0718518
190male meiosis I (GO:0007141)15.6340963
191synaptonemal complex organization (GO:0070193)14.5369574
192DNA synthesis involved in DNA repair (GO:0000731)14.4637159
193meiosis I (GO:0007127)12.5803658
194meiotic nuclear division (GO:0007126)11.1266341

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.01111571
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.76326518
3EZH2_22144423_ChIP-Seq_EOC_Human5.29963621
4GBX2_23144817_ChIP-Seq_PC3_Human4.25381679
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.73586240
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.98997019
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92163655
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39293972
9REST_21632747_ChIP-Seq_MESCs_Mouse2.33395658
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30460362
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27280162
12PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22551461
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.21386547
14TAF15_26573619_Chip-Seq_HEK293_Human2.19805089
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18003168
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.16653722
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.09728010
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07927941
19* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97397269
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.96703861
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.96208263
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95515966
23* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92663777
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92046596
25CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.89533807
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88779615
27IGF1R_20145208_ChIP-Seq_DFB_Human1.88765748
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88499490
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.81763566
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79999182
31STAT3_23295773_ChIP-Seq_U87_Human1.79585558
32E2F7_22180533_ChIP-Seq_HELA_Human1.78101862
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75252145
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73514918
35SMAD4_21799915_ChIP-Seq_A2780_Human1.73130874
36RUNX1_26923725_Chip-Seq_HPCs_Mouse1.68712911
37VDR_22108803_ChIP-Seq_LS180_Human1.67723177
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.67503964
39* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66999966
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66961065
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62760719
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62300006
43P300_19829295_ChIP-Seq_ESCs_Human1.61697214
44SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.60427515
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.58895135
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.56555145
47* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56068071
48FUS_26573619_Chip-Seq_HEK293_Human1.55529217
49PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53384198
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.52578830
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.51469435
52ZNF274_21170338_ChIP-Seq_K562_Hela1.51371336
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.51103345
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51043779
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.50214010
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49703529
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.48493115
58TCF4_23295773_ChIP-Seq_U87_Human1.47054685
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46665486
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45727059
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42445964
62RNF2_27304074_Chip-Seq_NSC_Mouse1.40361614
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.38608020
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38159774
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.38128308
66SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38083098
67TP53_22573176_ChIP-Seq_HFKS_Human1.37513579
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35817378
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.35299728
70DCP1A_22483619_ChIP-Seq_HELA_Human1.35029217
71* BCAT_22108803_ChIP-Seq_LS180_Human1.33533183
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32991148
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32851125
74SOX2_21211035_ChIP-Seq_LN229_Gbm1.31512708
75RNF2_27304074_Chip-Seq_ESCs_Mouse1.31378596
76* ERA_21632823_ChIP-Seq_H3396_Human1.30664233
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30089748
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.29627610
79AR_25329375_ChIP-Seq_VCAP_Human1.29411924
80EWS_26573619_Chip-Seq_HEK293_Human1.29011673
81YY1_22570637_ChIP-Seq_MALME-3M_Human1.28134692
82RUNX2_22187159_ChIP-Seq_PCA_Human1.28098455
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27992223
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27981365
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.27233710
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.26013135
87SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25602078
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25022768
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23897452
90EED_16625203_ChIP-ChIP_MESCs_Mouse1.22936307
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22140922
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.21381043
93* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20731361
94EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19515451
95RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19515451
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18905391
97P53_22387025_ChIP-Seq_ESCs_Mouse1.18615954
98FOXA1_25329375_ChIP-Seq_VCAP_Human1.18386517
99FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18386517
100PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17832841
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16990749
102FLI1_27457419_Chip-Seq_LIVER_Mouse1.16844731
103CMYC_18555785_Chip-Seq_ESCs_Mouse1.15350618
104FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15154314
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.14901078
106GATA3_26560356_Chip-Seq_TH1_Human1.13744557
107DROSHA_22980978_ChIP-Seq_HELA_Human1.13398439
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12946976
109PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12545289
110KDM2B_26808549_Chip-Seq_REH_Human1.12122164
111HOXB7_26014856_ChIP-Seq_BT474_Human1.12024887
112MYC_18940864_ChIP-ChIP_HL60_Human1.11857394
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.11575099
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11352826
115KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10688541
116KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10688541
117KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10688541
118TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.10202349
119YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10108700
120SOX2_18555785_Chip-Seq_ESCs_Mouse1.10066211
121ER_23166858_ChIP-Seq_MCF-7_Human1.08580217
122* PRDM14_20953172_ChIP-Seq_ESCs_Human1.08579436
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08457227
124CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08410840
125NMYC_18555785_Chip-Seq_ESCs_Mouse1.07633740
126SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07585677
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06039085
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05921564
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04853857
130HTT_18923047_ChIP-ChIP_STHdh_Human1.04375391
131ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04190563
132AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03885213
133RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03643296
134SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02967153
135AR_19668381_ChIP-Seq_PC3_Human1.02508123
136NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02434754
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02251137
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02251137
139MYC_19829295_ChIP-Seq_ESCs_Human1.00755830
140REST_19997604_ChIP-ChIP_NEURONS_Mouse1.00494658
141TP63_19390658_ChIP-ChIP_HaCaT_Human1.00397318
142P300_18555785_Chip-Seq_ESCs_Mouse0.99999509
143GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99517690
144RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98351731
145NFE2_27457419_Chip-Seq_LIVER_Mouse0.98234076
146* FLI1_21867929_ChIP-Seq_TH2_Mouse0.98168423
147* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97966544
148PHF8_20622853_ChIP-Seq_HELA_Human0.96207801
149CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95642654
150NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94722144
151MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92061125
152POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91371970
153PKCTHETA_26484144_Chip-Seq_BREAST_Human0.89795408
154FOXH1_21741376_ChIP-Seq_EPCs_Human0.89712820
155IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86461446
156CBP_20019798_ChIP-Seq_JUKART_Human0.86461446
157MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84875641
158* ETV1_20927104_ChIP-Seq_GIST48_Human0.84347572
159E2F1_17053090_ChIP-ChIP_MCF-7_Human0.84120012
160GABP_19822575_ChIP-Seq_HepG2_Human0.83871945
161SMAD_19615063_ChIP-ChIP_OVARY_Human0.83142069
162NANOG_19829295_ChIP-Seq_ESCs_Human0.82593773
163SOX2_19829295_ChIP-Seq_ESCs_Human0.82593773
164KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.82478477
165DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82162927
166YY1_21170310_ChIP-Seq_MESCs_Mouse0.81709554

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002210_abnormal_sex_determination5.48959224
2MP0008058_abnormal_DNA_repair5.30375568
3MP0002160_abnormal_reproductive_system4.24909261
4MP0010386_abnormal_urinary_bladder4.12388695
5MP0001145_abnormal_male_reproductive4.09685523
6MP0000653_abnormal_sex_gland3.75918361
7MP0004043_abnormal_pH_regulation3.68715473
8MP0005171_absent_coat_pigmentation3.30024554
9MP0003283_abnormal_digestive_organ3.28625630
10MP0009780_abnormal_chondrocyte_physiolo3.16494235
11MP0003136_yellow_coat_color3.14777609
12MP0003787_abnormal_imprinting3.12186706
13MP0003880_abnormal_central_pattern3.10073839
14MP0002909_abnormal_adrenal_gland3.06926857
15MP0002837_dystrophic_cardiac_calcinosis3.05451665
16MP0002693_abnormal_pancreas_physiology2.82276908
17MP0005389_reproductive_system_phenotype2.72972846
18MP0004270_analgesia2.66027404
19MP0001119_abnormal_female_reproductive2.64785592
20MP0004859_abnormal_synaptic_plasticity2.58635081
21MP0008995_early_reproductive_senescence2.40393732
22MP0006072_abnormal_retinal_apoptosis2.39880426
23MP0008004_abnormal_stomach_pH2.39226800
24MP0001944_abnormal_pancreas_morphology2.30387389
25MP0008877_abnormal_DNA_methylation2.25086695
26MP0002161_abnormal_fertility/fecundity2.23983284
27MP0002877_abnormal_melanocyte_morpholog2.19450149
28MP0005646_abnormal_pituitary_gland2.17333680
29MP0003635_abnormal_synaptic_transmissio2.15790707
30MP0005379_endocrine/exocrine_gland_phen2.12167839
31MP0003699_abnormal_female_reproductive2.10901216
32MP0000678_abnormal_parathyroid_gland2.07279412
33MP0000013_abnormal_adipose_tissue2.01191564
34MP0000462_abnormal_digestive_system1.99720082
35MP0003879_abnormal_hair_cell1.87763358
36MP0008007_abnormal_cellular_replicative1.87734906
37MP0009745_abnormal_behavioral_response1.83681552
38MP0000383_abnormal_hair_follicle1.83116434
39MP0002063_abnormal_learning/memory/cond1.81167584
40MP0010094_abnormal_chromosome_stability1.77493359
41MP0006276_abnormal_autonomic_nervous1.76163251
42MP0003646_muscle_fatigue1.74489658
43MP0001188_hyperpigmentation1.74316079
44MP0002572_abnormal_emotion/affect_behav1.71456896
45MP0001501_abnormal_sleep_pattern1.71088336
46MP0002272_abnormal_nervous_system1.68270628
47MP0001502_abnormal_circadian_rhythm1.64956082
48MP0000569_abnormal_digit_pigmentation1.64361087
49MP0001661_extended_life_span1.64040077
50MP0003195_calcinosis1.62175293
51MP0003693_abnormal_embryo_hatching1.59959901
52MP0002064_seizures1.56457015
53MP0002876_abnormal_thyroid_physiology1.53527820
54MP0003786_premature_aging1.53100536
55MP0002653_abnormal_ependyma_morphology1.50912622
56MP0000427_abnormal_hair_cycle1.48578677
57MP0002078_abnormal_glucose_homeostasis1.47563141
58MP0002734_abnormal_mechanical_nocicepti1.46418417
59MP0001765_abnormal_ion_homeostasis1.42673013
60MP0003183_abnormal_peptide_metabolism1.41011929
61MP0010678_abnormal_skin_adnexa1.37406976
62MP0003718_maternal_effect1.35454007
63MP0008789_abnormal_olfactory_epithelium1.35379804
64MP0009046_muscle_twitch1.34802375
65MP0001664_abnormal_digestion1.29427032
66MP0001984_abnormal_olfaction1.27054176
67MP0002638_abnormal_pupillary_reflex1.24726899
68MP0001968_abnormal_touch/_nociception1.21828809
69MP0003123_paternal_imprinting1.20759800
70MP0004145_abnormal_muscle_electrophysio1.20457352
71MP0008961_abnormal_basal_metabolism1.19967891
72MP0001986_abnormal_taste_sensitivity1.19532586
73MP0003121_genomic_imprinting1.19236545
74MP0002557_abnormal_social/conspecific_i1.18053320
75MP0006292_abnormal_olfactory_placode1.17548361
76MP0002735_abnormal_chemical_nociception1.16839488
77MP0002736_abnormal_nociception_after1.16475172
78MP0001486_abnormal_startle_reflex1.16338103
79MP0002067_abnormal_sensory_capabilities1.15725421
80MP0003111_abnormal_nucleus_morphology1.15577535
81MP0000538_abnormal_urinary_bladder1.15344880
82MP0005535_abnormal_body_temperature1.14734825
83MP0005220_abnormal_exocrine_pancreas1.14506992
84MP0003890_abnormal_embryonic-extraembry1.13077276
85MP0002733_abnormal_thermal_nociception1.12189839
86MP0001970_abnormal_pain_threshold1.11868815
87MP0002184_abnormal_innervation1.10891269
88MP0000631_abnormal_neuroendocrine_gland1.10274215
89MP0003122_maternal_imprinting1.09381438
90MP0005410_abnormal_fertilization1.08391345
91MP0001440_abnormal_grooming_behavior1.07941259
92MP0003953_abnormal_hormone_level1.07794870
93MP0005423_abnormal_somatic_nervous1.05785618
94MP0005187_abnormal_penis_morphology1.04499300
95MP0005409_darkened_coat_color1.03688216
96MP0003868_abnormal_feces_composition1.03394790
97MP0005248_abnormal_Harderian_gland1.01717021
98MP0010307_abnormal_tumor_latency1.01064549
99MP0005310_abnormal_salivary_gland0.99844011
100MP0008057_abnormal_DNA_replication0.98574983
101MP0003937_abnormal_limbs/digits/tail_de0.97806722
102MP0005645_abnormal_hypothalamus_physiol0.95851837
103MP0000613_abnormal_salivary_gland0.95024002
104MP0004858_abnormal_nervous_system0.94777824
105MP0002234_abnormal_pharynx_morphology0.94455898
106MP0001915_intracranial_hemorrhage0.94007478
107MP0001485_abnormal_pinna_reflex0.93745575
108MP0003941_abnormal_skin_development0.91240855
109MP0005174_abnormal_tail_pigmentation0.90275623
110MP0003329_amyloid_beta_deposits0.90270455
111MP0003077_abnormal_cell_cycle0.88333046
112MP0000003_abnormal_adipose_tissue0.86836470
113MP0000955_abnormal_spinal_cord0.86561434
114MP0005253_abnormal_eye_physiology0.85514354
115MP0002095_abnormal_skin_pigmentation0.84885696
116MP0003119_abnormal_digestive_system0.83581437
117MP0000015_abnormal_ear_pigmentation0.82305290
118MP0009703_decreased_birth_body0.82202307
119MP0003943_abnormal_hepatobiliary_system0.80956229
120MP0004264_abnormal_extraembryonic_tissu0.80091242
121MP0006035_abnormal_mitochondrial_morpho0.79989102
122MP0000372_irregular_coat_pigmentation0.78634549
123MP0002066_abnormal_motor_capabilities/c0.77245833
124MP0001929_abnormal_gametogenesis0.76648685
125MP0001270_distended_abdomen0.76465409
126MP0001919_abnormal_reproductive_system0.75936190
127MP0000579_abnormal_nail_morphology0.75843663
128MP0004885_abnormal_endolymph0.75621164
129MP0001963_abnormal_hearing_physiology0.75404287
130MP0002229_neurodegeneration0.75273622
131MP0003698_abnormal_male_reproductive0.74699226
132MP0005551_abnormal_eye_electrophysiolog0.74479758
133MP0002069_abnormal_eating/drinking_beha0.74423991
134MP0005448_abnormal_energy_balance0.74304244
135MP0002882_abnormal_neuron_morphology0.73768608
136MP0002084_abnormal_developmental_patter0.73419839
137MP0002177_abnormal_outer_ear0.73204567
138MP0002751_abnormal_autonomic_nervous0.71923324
139MP0000647_abnormal_sebaceous_gland0.71694938
140MP0004924_abnormal_behavior0.71162407
141MP0010030_abnormal_orbit_morphology0.70445226
142MP0005499_abnormal_olfactory_system0.69413897
143MP0005394_taste/olfaction_phenotype0.69413897
144MP0002282_abnormal_trachea_morphology0.68744839
145MP0001730_embryonic_growth_arrest0.67503927
146MP0002249_abnormal_larynx_morphology0.65569290
147MP0001697_abnormal_embryo_size0.63787847
148MP0003936_abnormal_reproductive_system0.63499341
149MP0003938_abnormal_ear_development0.62687924
150MP0004019_abnormal_vitamin_homeostasis0.61441779
151MP0000778_abnormal_nervous_system0.60730571
152MP0000358_abnormal_cell_content/0.58085734
153MP0005647_abnormal_sex_gland0.54489258
154MP0001672_abnormal_embryogenesis/_devel0.53008004
155MP0005380_embryogenesis_phenotype0.53008004
156MP0002085_abnormal_embryonic_tissue0.50784751
157MP0003567_abnormal_fetal_cardiomyocyte0.47797025
158MP0001243_abnormal_dermal_layer0.47528691
159MP0003984_embryonic_growth_retardation0.46975414
160MP0005275_abnormal_skin_tensile0.45521293
161MP0002088_abnormal_embryonic_growth/wei0.45340693
162MP0005058_abnormal_lysosome_morphology0.45199219
163MP0008260_abnormal_autophagy0.44269442
164MP0003861_abnormal_nervous_system0.44194661
165MP0002233_abnormal_nose_morphology0.42804292
166MP0009250_abnormal_appendicular_skeleto0.42222910
167MP0002139_abnormal_hepatobiliary_system0.41404532
168MP0000313_abnormal_cell_death0.41178678
169MP0002971_abnormal_brown_adipose0.38801963
170MP0006036_abnormal_mitochondrial_physio0.38416560
171MP0004036_abnormal_muscle_relaxation0.38373657
172MP0005395_other_phenotype0.38248839
173MP0002114_abnormal_axial_skeleton0.38154939
174MP0002116_abnormal_craniofacial_bone0.38148511
175MP0008932_abnormal_embryonic_tissue0.37584696
176MP0004742_abnormal_vestibular_system0.32453001

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous abortion (HP:0005268)7.42499628
2Azoospermia (HP:0000027)6.88537398
3Gonadotropin excess (HP:0000837)6.31187746
4Oligodactyly (hands) (HP:0001180)5.85907700
5Tubulointerstitial nephritis (HP:0001970)5.42020239
6Hyperinsulinemic hypoglycemia (HP:0000825)5.29277314
7Abnormal spermatogenesis (HP:0008669)5.19319447
8Degeneration of the lateral corticospinal tracts (HP:0002314)5.00425560
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.00425560
10Large for gestational age (HP:0001520)4.72581669
11Hypoglycemic seizures (HP:0002173)4.71830807
12Symptomatic seizures (HP:0011145)4.59655164
13Shoulder girdle muscle weakness (HP:0003547)4.56403613
14Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.12754923
15Blue irides (HP:0000635)4.12305216
16Focal motor seizures (HP:0011153)4.02792666
17Oligodactyly (HP:0012165)4.01587335
18Hypoglycemic coma (HP:0001325)3.99277554
19Insulin-resistant diabetes mellitus (HP:0000831)3.94282623
2011 pairs of ribs (HP:0000878)3.94001241
21Rimmed vacuoles (HP:0003805)3.91163180
22Increased nuchal translucency (HP:0010880)3.80561488
23Decreased circulating renin level (HP:0003351)3.79214090
24Abnormality of the corticospinal tract (HP:0002492)3.79016230
25Chronic bronchitis (HP:0004469)3.60973488
26Papillary thyroid carcinoma (HP:0002895)3.55777310
27Horizontal nystagmus (HP:0000666)3.48285045
28Visual hallucinations (HP:0002367)3.48038471
29Impaired vibration sensation in the lower limbs (HP:0002166)3.41944551
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.41690997
31Curly hair (HP:0002212)3.37709468
32Atonic seizures (HP:0010819)3.33388758
33Broad distal phalanx of finger (HP:0009836)3.29778938
34Amyotrophic lateral sclerosis (HP:0007354)3.25701747
35Abnormality of the lower motor neuron (HP:0002366)3.25493519
36Abnormality of calcium-phosphate metabolism (HP:0100530)3.23929175
37Ectopic kidney (HP:0000086)3.20145713
38Epileptic encephalopathy (HP:0200134)3.14325078
39Hyperglycemia (HP:0003074)3.11388459
40Hepatoblastoma (HP:0002884)3.06597647
41Volvulus (HP:0002580)3.02901235
42Facial hemangioma (HP:0000329)3.01766791
43Aplasia/Hypoplasia of the sternum (HP:0006714)3.00224508
44Large hands (HP:0001176)2.99937199
45Absent eyebrow (HP:0002223)2.97472587
46Nephronophthisis (HP:0000090)2.95388528
47Metaphyseal cupping (HP:0003021)2.87495258
48Abnormality of the renal medulla (HP:0100957)2.85516994
49Abnormal lung lobation (HP:0002101)2.74028631
50Nephroblastoma (Wilms tumor) (HP:0002667)2.70709543
51Epileptiform EEG discharges (HP:0011182)2.68839963
52Hypothermia (HP:0002045)2.68334726
53Short nail (HP:0001799)2.67939430
54Osteomalacia (HP:0002749)2.66808988
55Abnormality of chromosome segregation (HP:0002916)2.66374313
56Embryonal renal neoplasm (HP:0011794)2.64239890
57Hypoplastic iliac wings (HP:0002866)2.63355123
58Small intestinal stenosis (HP:0012848)2.58437108
59Duodenal stenosis (HP:0100867)2.58437108
60Abnormal protein glycosylation (HP:0012346)2.57045213
61Abnormal glycosylation (HP:0012345)2.57045213
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.57045213
63Abnormal protein N-linked glycosylation (HP:0012347)2.57045213
64Atrophy/Degeneration involving motor neurons (HP:0007373)2.55923312
65Hand muscle atrophy (HP:0009130)2.55497323
66EEG with generalized epileptiform discharges (HP:0011198)2.55189344
67Absence seizures (HP:0002121)2.55025730
68Abnormality of endocrine pancreas physiology (HP:0012093)2.53326140
69Abnormality of the pancreatic islet cells (HP:0006476)2.53326140
70Tubulointerstitial abnormality (HP:0001969)2.50794495
71Capillary hemangiomas (HP:0005306)2.50675806
72Bifid tongue (HP:0010297)2.50558155
73Chromsome breakage (HP:0040012)2.48750485
74Hypokalemia (HP:0002900)2.47422395
75Upper motor neuron abnormality (HP:0002127)2.47181819
76Abnormal respiratory motile cilium physiology (HP:0012261)2.45152018
77Hyperventilation (HP:0002883)2.44813645
78Medial flaring of the eyebrow (HP:0010747)2.44487643
79Supernumerary spleens (HP:0009799)2.43078617
80Pancreatic islet-cell hyperplasia (HP:0004510)2.42423092
81Type II lissencephaly (HP:0007260)2.42117421
82Ketoacidosis (HP:0001993)2.41008284
83Rhinitis (HP:0012384)2.40069105
84Generalized tonic-clonic seizures (HP:0002069)2.38263569
85Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38085105
86Wrist flexion contracture (HP:0001239)2.37103343
87Hypsarrhythmia (HP:0002521)2.36836729
88Wide intermamillary distance (HP:0006610)2.33937856
89Type I transferrin isoform profile (HP:0003642)2.33230255
90Abnormality of cochlea (HP:0000375)2.31986355
91Non-midline cleft lip (HP:0100335)2.31774751
92Abnormality of DNA repair (HP:0003254)2.29870515
93Protruding tongue (HP:0010808)2.26071172
94Retinal dysplasia (HP:0007973)2.25780938
95Generalized aminoaciduria (HP:0002909)2.24743221
96Abnormality of alanine metabolism (HP:0010916)2.24075136
97Hyperalaninemia (HP:0003348)2.24075136
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24075136
99Dialeptic seizures (HP:0011146)2.22501671
100Urinary urgency (HP:0000012)2.22344593
101Focal seizures (HP:0007359)2.20537581
102Intestinal atresia (HP:0011100)2.19070403
103Scotoma (HP:0000575)2.18875733
104Agitation (HP:0000713)2.18792215
105Abnormal pancreas size (HP:0012094)2.18445531
106Hyperpituitarism (HP:0010514)2.17954558
107Resting tremor (HP:0002322)2.17943623
108Fair hair (HP:0002286)2.17853898
109Thyroid carcinoma (HP:0002890)2.16821795
110Dynein arm defect of respiratory motile cilia (HP:0012255)2.16474955
111Absent/shortened dynein arms (HP:0200106)2.16474955
112Truncal obesity (HP:0001956)2.16351005
113Cubitus valgus (HP:0002967)2.16097451
114Gait imbalance (HP:0002141)2.15895548
115Hypoplasia of the fovea (HP:0007750)2.15667550
116Aplasia/Hypoplasia of the fovea (HP:0008060)2.15667550
117Abnormality of renin-angiotensin system (HP:0000847)2.15623922
118Limb hypertonia (HP:0002509)2.12090367
119Spastic gait (HP:0002064)2.10693656
120Abnormality of the labia minora (HP:0012880)2.10462972
121Congenital primary aphakia (HP:0007707)2.10274216
122Abnormal delivery (HP:0001787)2.09555268
123Drooling (HP:0002307)2.08915846
124Excessive salivation (HP:0003781)2.08915846
125Abnormality of the duodenum (HP:0002246)2.08895147
126Impaired vibratory sensation (HP:0002495)2.07767357
127Late onset (HP:0003584)2.07642854
128Conjugated hyperbilirubinemia (HP:0002908)2.05595239
129Widely spaced teeth (HP:0000687)2.05491232
130Hyperactive renin-angiotensin system (HP:0000841)2.04397687
131Menstrual irregularities (HP:0000858)2.03587464
132Multicystic kidney dysplasia (HP:0000003)2.03399081
133Nephrogenic diabetes insipidus (HP:0009806)2.03150217
134Male infertility (HP:0003251)2.00460904
135Abnormality of potassium homeostasis (HP:0011042)1.99989825
136Median cleft lip (HP:0000161)1.99449375
137Maternal diabetes (HP:0009800)1.97146515
138Labial hypoplasia (HP:0000066)1.96272292
139Abnormality of the fovea (HP:0000493)1.94797077
140Neoplasm of the thyroid gland (HP:0100031)1.93061838
141Dysautonomia (HP:0002459)1.92310504
142Molar tooth sign on MRI (HP:0002419)1.92159011
143Abnormality of midbrain morphology (HP:0002418)1.92159011
144Abnormality of the labia (HP:0000058)1.91632201
145Enlarged penis (HP:0000040)1.90140569
146Hyperkalemia (HP:0002153)1.90131514
147Hemiparesis (HP:0001269)1.90009534
148Urinary bladder sphincter dysfunction (HP:0002839)1.89944012
149Abnormal autonomic nervous system physiology (HP:0012332)1.89666187
150Lip pit (HP:0100267)1.87922622
151Proximal placement of thumb (HP:0009623)1.86203831
152Vertebral arch anomaly (HP:0008438)1.84833458
153Occipital encephalocele (HP:0002085)1.84759187
154Neoplasm of the adrenal cortex (HP:0100641)1.83934789
155Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82441622
156Abnormality of the dental root (HP:0006486)1.81313422
157Taurodontia (HP:0000679)1.81313422
158Abnormality of permanent molar morphology (HP:0011071)1.81313422
159Acute hepatic failure (HP:0006554)1.80647330
160Abnormality of the vocal cords (HP:0008777)1.80496193
161Abnormality of dentin (HP:0010299)1.79843355
162Cortical visual impairment (HP:0100704)1.79817530
163Infertility (HP:0000789)1.79037185
164Upper limb muscle weakness (HP:0003484)1.78791113
165Upper limb amyotrophy (HP:0009129)1.78112251
166Distal upper limb amyotrophy (HP:0007149)1.78112251
167Long foot (HP:0001833)1.77779227
168Vaginal atresia (HP:0000148)1.77555532
169Genital tract atresia (HP:0001827)1.76844816
170Truncal ataxia (HP:0002078)1.76574180
171Bell-shaped thorax (HP:0001591)1.75551923
172Pheochromocytoma (HP:0002666)1.75551078
173Atelectasis (HP:0100750)1.75483824
174Limb-girdle muscle weakness (HP:0003325)1.75184199
175Stage 5 chronic kidney disease (HP:0003774)1.75058072
176Cystic hygroma (HP:0000476)1.74338750
177Hypoplastic female external genitalia (HP:0012815)1.74178572
178Short tibia (HP:0005736)1.73638385
179Insulin resistance (HP:0000855)1.73516216
180Lower limb muscle weakness (HP:0007340)1.73323632
181Hypoplastic labia majora (HP:0000059)1.71648417
182Absent eyelashes (HP:0000561)1.69652239
183Hypoplasia of the radius (HP:0002984)1.69068991
184Morphological abnormality of the inner ear (HP:0011390)1.68591540
185Aplasia/Hypoplasia of the tibia (HP:0005772)1.68510347
186Loss of speech (HP:0002371)1.68144807
187Abnormality of chromosome stability (HP:0003220)1.67968744
188Febrile seizures (HP:0002373)1.67031125
189Preaxial hand polydactyly (HP:0001177)1.65614420
190Deep palmar crease (HP:0006191)1.65467005
191Clitoromegaly (HP:0000057)1.65438867
192Progressive cerebellar ataxia (HP:0002073)1.65196399
193Abnormal ciliary motility (HP:0012262)1.65087894

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK195.75561695
2INSRR4.43160164
3NTRK34.41242156
4PASK3.40682038
5CASK3.35680079
6PRKD33.15884874
7STK38L3.02510291
8MAPK153.01762696
9OXSR12.96485871
10AKT32.74264653
11BMPR22.67139772
12ICK2.65800850
13MAP2K72.64389897
14NEK92.50371282
15BRAF2.39654475
16CAMK1G2.33251088
17TAOK32.26206132
18FGR2.20207281
19MAP3K22.19115566
20MAP3K42.17025152
21NTRK12.11315948
22BMX2.07130975
23TTK1.88028413
24MAP3K91.68791535
25CSF1R1.66604391
26STK381.60881413
27WNK41.58181657
28TNIK1.58159246
29RIPK41.56621265
30EPHA41.55775706
31IRAK11.55658330
32NME11.55622024
33ARAF1.55490018
34HIPK21.52814056
35IRAK21.41858128
36STK161.41707349
37NUAK11.38604243
38PLK11.36865483
39PLK21.35554733
40MAP3K11.17618709
41PDGFRB1.13411134
42WEE10.99453150
43MAPK130.98718737
44WNK30.98696287
45LATS10.97842834
46FLT30.97760030
47ATR0.97662754
48MAP3K60.96911107
49SGK2230.93189850
50SGK4940.93189850
51FRK0.92902386
52PRPF4B0.92354112
53CSNK1A1L0.90435438
54PINK10.90226524
55PDK30.90067444
56PDK40.90067444
57KSR20.90030566
58PNCK0.89042795
59VRK10.88432109
60CSNK1G20.87643931
61BCR0.86768430
62SGK20.86424248
63RPS6KB10.85960954
64CHEK10.85380157
65PRKD20.85287971
66STK110.84715568
67MAP3K130.83238702
68DAPK20.81492491
69PDK10.81454937
70KSR10.81346542
71PRKCE0.81204862
72MAP2K40.80599541
73NEK10.79885072
74ATM0.79679202
75PDPK10.79223809
76ZAK0.78842875
77CAMK2A0.76949811
78CAMK2B0.76360737
79CSNK1G30.72247721
80EGFR0.71708277
81CDC42BPA0.71243429
82CDK80.70579620
83PRKCG0.70385523
84PRKCH0.69769565
85PDGFRA0.67491897
86UHMK10.67448199
87CDK50.66492479
88MAP2K20.66404889
89TSSK60.66390080
90CSNK1G10.66289823
91MST1R0.66256150
92BRSK10.65892122
93NEK60.63153424
94TIE10.62214854
95PTK20.61960856
96GRK50.61685587
97TYRO30.60742416
98RAF10.60590322
99DAPK10.59062772
100CDK60.57011843
101CAMK2D0.55263346
102CDK30.55231543
103MOS0.55042163
104MINK10.54523988
105PAK30.54403962
106SGK10.54164674
107CSNK1A10.53752612
108MARK30.52806565
109PAK60.52141581
110MAP3K50.51479225
111MAPK70.50529700
112CAMKK20.50517244
113NEK20.50174931
114FGFR30.48735960
115DYRK1A0.48513797
116GRK70.48248431
117MET0.47918870
118RET0.45701316
119NTRK20.45069596
120PRKCI0.44053848
121AURKA0.43091675
122CSNK1E0.42942839
123BRD40.42238884
124WNK10.41203996
125IRAK30.39309090
126MAPK100.39251165
127CDK11A0.38132148
128PLK40.37412547
129PRKACA0.36491106
130PTK2B0.36381991
131SGK30.35301347
132BMPR1B0.34976143
133CDK20.34389034
134PDK20.34221107
135MELK0.33972098
136ROCK10.33445465
137MARK10.33333937
138CDK10.32017556
139BRSK20.31852025
140STK240.31498001
141YES10.30101732
142FER0.29328796
143CAMK10.29321024
144NLK0.28402893
145CDK40.27372112
146PRKCZ0.27278449
147CDK90.27188161
148PIK3CG0.27182312
149TLK10.26495792
150PLK30.26241169
151PRKG10.26169388
152TAOK10.25815218
153MUSK0.25364712
154IGF1R0.25047764
155LIMK10.24815408
156CCNB10.24771064
157PRKDC0.23650918
158STK390.23635863
159PRKACB0.23548313
160FGFR10.19695180
161DYRK30.19397257
162BUB10.18990958

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034406.12408036
2Maturity onset diabetes of the young_Homo sapiens_hsa049505.85955616
3Protein export_Homo sapiens_hsa030604.31714558
4Non-homologous end-joining_Homo sapiens_hsa034503.67757333
5Mismatch repair_Homo sapiens_hsa034303.47844006
6Cell cycle_Homo sapiens_hsa041103.44455525
7Sulfur relay system_Homo sapiens_hsa041223.40653290
8Insulin secretion_Homo sapiens_hsa049113.21955975
9DNA replication_Homo sapiens_hsa030303.20486218
10Nucleotide excision repair_Homo sapiens_hsa034203.17727599
11RNA transport_Homo sapiens_hsa030132.86695194
12Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.64144128
13Long-term potentiation_Homo sapiens_hsa047202.59814635
14Nicotine addiction_Homo sapiens_hsa050332.51826327
15Fanconi anemia pathway_Homo sapiens_hsa034602.49260917
16Propanoate metabolism_Homo sapiens_hsa006402.48156304
17Amphetamine addiction_Homo sapiens_hsa050312.36180006
18Sulfur metabolism_Homo sapiens_hsa009202.29131473
19Taste transduction_Homo sapiens_hsa047422.20476487
20Circadian entrainment_Homo sapiens_hsa047132.19755504
21mRNA surveillance pathway_Homo sapiens_hsa030152.09654647
22Base excision repair_Homo sapiens_hsa034102.00480007
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94965496
24Dorso-ventral axis formation_Homo sapiens_hsa043201.94859385
25Glutamatergic synapse_Homo sapiens_hsa047241.86573573
26Cocaine addiction_Homo sapiens_hsa050301.82932471
27Type II diabetes mellitus_Homo sapiens_hsa049301.77414478
28Serotonergic synapse_Homo sapiens_hsa047261.72042657
29Vibrio cholerae infection_Homo sapiens_hsa051101.69707212
30Synaptic vesicle cycle_Homo sapiens_hsa047211.69091770
31GABAergic synapse_Homo sapiens_hsa047271.66113700
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.64588836
33Morphine addiction_Homo sapiens_hsa050321.64436306
34Dopaminergic synapse_Homo sapiens_hsa047281.55995315
35Circadian rhythm_Homo sapiens_hsa047101.48842890
36Lysine degradation_Homo sapiens_hsa003101.47648645
37Phenylalanine metabolism_Homo sapiens_hsa003601.46352955
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.41093924
39beta-Alanine metabolism_Homo sapiens_hsa004101.40429661
40RNA degradation_Homo sapiens_hsa030181.40023922
41Pyruvate metabolism_Homo sapiens_hsa006201.39559591
42Collecting duct acid secretion_Homo sapiens_hsa049661.37761317
43Salivary secretion_Homo sapiens_hsa049701.33722149
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33176331
45Proteasome_Homo sapiens_hsa030501.32378746
46Cholinergic synapse_Homo sapiens_hsa047251.27654554
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27130927
48Long-term depression_Homo sapiens_hsa047301.26207962
49Estrogen signaling pathway_Homo sapiens_hsa049151.22860518
50GnRH signaling pathway_Homo sapiens_hsa049121.21091726
51Calcium signaling pathway_Homo sapiens_hsa040201.18541075
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17591666
53Renin secretion_Homo sapiens_hsa049241.15694352
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13501942
55mTOR signaling pathway_Homo sapiens_hsa041501.12807968
56Vascular smooth muscle contraction_Homo sapiens_hsa042701.10719042
57cAMP signaling pathway_Homo sapiens_hsa040241.07533570
58Pancreatic secretion_Homo sapiens_hsa049721.06415639
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03869062
60Gap junction_Homo sapiens_hsa045401.03766078
61p53 signaling pathway_Homo sapiens_hsa041151.03721724
62Endometrial cancer_Homo sapiens_hsa052131.02040861
63Gastric acid secretion_Homo sapiens_hsa049711.00722254
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98505853
65Glucagon signaling pathway_Homo sapiens_hsa049220.97682112
66Prolactin signaling pathway_Homo sapiens_hsa049170.97553286
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97135107
68ErbB signaling pathway_Homo sapiens_hsa040120.95288546
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94459984
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91151449
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90993036
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88005092
73Type I diabetes mellitus_Homo sapiens_hsa049400.87530276
74Retinol metabolism_Homo sapiens_hsa008300.87527309
75Thyroid hormone synthesis_Homo sapiens_hsa049180.86145039
76Glioma_Homo sapiens_hsa052140.85615889
77Oxytocin signaling pathway_Homo sapiens_hsa049210.84120039
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83579247
79Ovarian steroidogenesis_Homo sapiens_hsa049130.83046203
80Small cell lung cancer_Homo sapiens_hsa052220.82217368
81Regulation of autophagy_Homo sapiens_hsa041400.82049692
82Alcoholism_Homo sapiens_hsa050340.80968005
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.80123184
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75403741
85ABC transporters_Homo sapiens_hsa020100.73545049
86Vitamin digestion and absorption_Homo sapiens_hsa049770.72215917
87Fatty acid biosynthesis_Homo sapiens_hsa000610.70405573
88Melanogenesis_Homo sapiens_hsa049160.70082078
89Choline metabolism in cancer_Homo sapiens_hsa052310.70045353
90Olfactory transduction_Homo sapiens_hsa047400.66756924
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66464719
92Spliceosome_Homo sapiens_hsa030400.66100520
93Sphingolipid metabolism_Homo sapiens_hsa006000.64689358
94Alzheimers disease_Homo sapiens_hsa050100.64204014
95Inositol phosphate metabolism_Homo sapiens_hsa005620.64158742
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62004441
97Linoleic acid metabolism_Homo sapiens_hsa005910.61980507
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60764359
99Insulin signaling pathway_Homo sapiens_hsa049100.60507482
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59864556
101Renal cell carcinoma_Homo sapiens_hsa052110.59192614
102Folate biosynthesis_Homo sapiens_hsa007900.58936682
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.58373465
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57694443
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.56900077
106Oocyte meiosis_Homo sapiens_hsa041140.55429062
107N-Glycan biosynthesis_Homo sapiens_hsa005100.53647301
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52904572
109Fatty acid degradation_Homo sapiens_hsa000710.50688928
110Fatty acid metabolism_Homo sapiens_hsa012120.49395907
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.49263526
112Selenocompound metabolism_Homo sapiens_hsa004500.49170195
113VEGF signaling pathway_Homo sapiens_hsa043700.47835213
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47067814
115Ras signaling pathway_Homo sapiens_hsa040140.46619880
116Pyrimidine metabolism_Homo sapiens_hsa002400.46267453
117FoxO signaling pathway_Homo sapiens_hsa040680.44270637
118Wnt signaling pathway_Homo sapiens_hsa043100.43852848
119Ether lipid metabolism_Homo sapiens_hsa005650.43441327
120Non-small cell lung cancer_Homo sapiens_hsa052230.42647948
121Steroid biosynthesis_Homo sapiens_hsa001000.42325921
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42028854
123Oxidative phosphorylation_Homo sapiens_hsa001900.41659053
124Basal transcription factors_Homo sapiens_hsa030220.41523556
125Prion diseases_Homo sapiens_hsa050200.40020142
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39994585
127Fat digestion and absorption_Homo sapiens_hsa049750.39021853
128MAPK signaling pathway_Homo sapiens_hsa040100.38562467
129Parkinsons disease_Homo sapiens_hsa050120.37280995
130Lysosome_Homo sapiens_hsa041420.37081353
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.36235226
132TGF-beta signaling pathway_Homo sapiens_hsa043500.33318622
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31057642
134Tyrosine metabolism_Homo sapiens_hsa003500.30278981
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29172550
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28343750
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.28242019
138Butanoate metabolism_Homo sapiens_hsa006500.27574937
139Phototransduction_Homo sapiens_hsa047440.27257127
140Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27108676
141Protein digestion and absorption_Homo sapiens_hsa049740.25889523
142Adherens junction_Homo sapiens_hsa045200.25335227
143Huntingtons disease_Homo sapiens_hsa050160.25164515
144Axon guidance_Homo sapiens_hsa043600.25122564
145Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24869422
146Prostate cancer_Homo sapiens_hsa052150.24767639
147Insulin resistance_Homo sapiens_hsa049310.24546104
148HTLV-I infection_Homo sapiens_hsa051660.23639502
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.22759220
150Cardiac muscle contraction_Homo sapiens_hsa042600.22641390
151Purine metabolism_Homo sapiens_hsa002300.22391969
152Legionellosis_Homo sapiens_hsa051340.19695664
153Glycerolipid metabolism_Homo sapiens_hsa005610.19121370
154Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17410033
155Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12235955
156Metabolic pathways_Homo sapiens_hsa011000.11585253
157Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.11397826
158Melanoma_Homo sapiens_hsa052180.08898231
159Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.07130352
160Peroxisome_Homo sapiens_hsa041460.06927427
161Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.03390048

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