RAD51B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.80950500
2telomere maintenance via semi-conservative replication (GO:0032201)5.62524882
3DNA strand elongation (GO:0022616)5.55185152
4DNA replication initiation (GO:0006270)5.40410667
5telomere maintenance via recombination (GO:0000722)5.30618067
6DNA unwinding involved in DNA replication (GO:0006268)5.27200118
7mitotic recombination (GO:0006312)5.09916412
8protein localization to kinetochore (GO:0034501)5.00127476
9CENP-A containing nucleosome assembly (GO:0034080)4.80104645
10chromatin remodeling at centromere (GO:0031055)4.64200342
11DNA replication checkpoint (GO:0000076)4.54818977
12telomere maintenance via telomere lengthening (GO:0010833)4.40239526
13nucleobase biosynthetic process (GO:0046112)4.39805190
14kinetochore organization (GO:0051383)4.35840326
15mitotic metaphase plate congression (GO:0007080)4.33160217
16mitotic chromosome condensation (GO:0007076)4.30602883
17nucleotide-excision repair, DNA gap filling (GO:0006297)4.28597682
18DNA replication-independent nucleosome assembly (GO:0006336)4.27541315
19DNA replication-independent nucleosome organization (GO:0034724)4.27541315
20protein localization to chromosome, centromeric region (GO:0071459)4.27056293
21DNA double-strand break processing (GO:0000729)4.24806544
22ribosomal small subunit assembly (GO:0000028)4.23530110
23attachment of spindle microtubules to kinetochore (GO:0008608)4.22782802
24purine nucleobase biosynthetic process (GO:0009113)4.11615461
25DNA deamination (GO:0045006)4.08974341
26regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.07771148
27IMP biosynthetic process (GO:0006188)4.01018233
28* recombinational repair (GO:0000725)4.00960369
29* double-strand break repair via homologous recombination (GO:0000724)4.00865752
30mitotic nuclear envelope disassembly (GO:0007077)3.95887097
31negative regulation of DNA-dependent DNA replication (GO:2000104)3.94468564
32metaphase plate congression (GO:0051310)3.82745727
33histone exchange (GO:0043486)3.81429408
34IMP metabolic process (GO:0046040)3.80749191
35kinetochore assembly (GO:0051382)3.75139702
36mitotic sister chromatid segregation (GO:0000070)3.74692647
37establishment of chromosome localization (GO:0051303)3.71493859
38respiratory chain complex IV assembly (GO:0008535)3.69453308
39DNA replication-dependent nucleosome assembly (GO:0006335)3.68780728
40DNA replication-dependent nucleosome organization (GO:0034723)3.68780728
41telomere maintenance (GO:0000723)3.64971275
42nuclear envelope disassembly (GO:0051081)3.64014890
43membrane disassembly (GO:0030397)3.64014890
44deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.63786791
45telomere organization (GO:0032200)3.62750969
46proteasome assembly (GO:0043248)3.62109980
47maturation of SSU-rRNA (GO:0030490)3.60509415
48nuclear pore organization (GO:0006999)3.58757024
49regulation of spindle organization (GO:0090224)3.57055268
50centriole replication (GO:0007099)3.56000817
51translesion synthesis (GO:0019985)3.53291495
52meiotic chromosome segregation (GO:0045132)3.52712075
53sister chromatid segregation (GO:0000819)3.51176180
54cytochrome complex assembly (GO:0017004)3.49459186
55nuclear pore complex assembly (GO:0051292)3.49181872
56DNA strand renaturation (GO:0000733)3.45149575
57regulation of mitotic spindle checkpoint (GO:1903504)3.44406893
58regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.44406893
59formation of translation preinitiation complex (GO:0001731)3.42527668
60protein complex biogenesis (GO:0070271)3.41389809
61folic acid-containing compound biosynthetic process (GO:0009396)3.39851880
62maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.39603105
63synapsis (GO:0007129)3.38803849
64platelet dense granule organization (GO:0060155)3.37605586
65mitotic sister chromatid cohesion (GO:0007064)3.36985655
66negative regulation of DNA recombination (GO:0045910)3.36163767
67mismatch repair (GO:0006298)3.34883799
68regulation of double-strand break repair via homologous recombination (GO:0010569)3.34799481
69mitochondrial respiratory chain complex assembly (GO:0033108)3.32097260
70positive regulation of histone H3-K4 methylation (GO:0051571)3.31918786
71resolution of meiotic recombination intermediates (GO:0000712)3.31636782
72DNA geometric change (GO:0032392)3.31286332
73regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.30735051
74DNA duplex unwinding (GO:0032508)3.30586855
75DNA topological change (GO:0006265)3.26051726
76protein K6-linked ubiquitination (GO:0085020)3.25693056
77chromatin assembly or disassembly (GO:0006333)3.21263254
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.21105410
79chromosome segregation (GO:0007059)3.18442730
80deoxyribonucleotide biosynthetic process (GO:0009263)3.18305818
81postreplication repair (GO:0006301)3.16338243
82DNA integration (GO:0015074)3.15706428
83transcription-coupled nucleotide-excision repair (GO:0006283)3.13265108
84RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.12484169
85* double-strand break repair (GO:0006302)3.12366932
86DNA catabolic process, exonucleolytic (GO:0000738)3.12327306
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.12100770
88G1/S transition of mitotic cell cycle (GO:0000082)3.11567919
89cell cycle G1/S phase transition (GO:0044843)3.11567919
90spindle checkpoint (GO:0031577)3.11477331
91somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.11196714
92somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.11196714
93isotype switching (GO:0045190)3.11196714
94establishment of integrated proviral latency (GO:0075713)3.10974644
95neural tube formation (GO:0001841)3.09916039
96regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.06211777
97somatic hypermutation of immunoglobulin genes (GO:0016446)3.06017253
98somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06017253
99DNA conformation change (GO:0071103)3.05965890
100pseudouridine synthesis (GO:0001522)3.04482780
101regulation of centrosome cycle (GO:0046605)3.03108348
102replication fork processing (GO:0031297)3.02914606
103ribosomal small subunit biogenesis (GO:0042274)3.02696771
104viral transcription (GO:0019083)3.02527972
105mitochondrial respiratory chain complex I assembly (GO:0032981)3.02034784
106NADH dehydrogenase complex assembly (GO:0010257)3.02034784
107mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.02034784
108base-excision repair (GO:0006284)3.01889448
109translational termination (GO:0006415)3.01797727
110protein localization to chromosome (GO:0034502)2.99375197
111mitotic cell cycle (GO:0000278)2.99363986
112regulation of chromosome segregation (GO:0051983)2.98103330
113positive regulation of chromosome segregation (GO:0051984)2.97289004
114ribosome biogenesis (GO:0042254)2.96595346
115regulation of mitotic metaphase/anaphase transition (GO:0030071)2.96367901
116negative regulation of mitotic sister chromatid separation (GO:2000816)2.96274399
117negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96274399
118negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96274399
119negative regulation of sister chromatid segregation (GO:0033046)2.96274399
120negative regulation of chromosome segregation (GO:0051985)2.95092502
121ribonucleoprotein complex biogenesis (GO:0022613)2.93848259
122spindle assembly checkpoint (GO:0071173)2.93505533
123rRNA processing (GO:0006364)2.93410997
124ATP-dependent chromatin remodeling (GO:0043044)2.92512646
125DNA replication (GO:0006260)2.91271024
126regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.90724130
127negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.88973446
128peptidyl-histidine modification (GO:0018202)2.88456062
129* DNA recombination (GO:0006310)2.88037345
130branched-chain amino acid catabolic process (GO:0009083)2.87838193
131mitochondrial DNA replication (GO:0006264)2.86506538
132spliceosomal snRNP assembly (GO:0000387)2.86438568
133mitotic spindle assembly checkpoint (GO:0007094)2.85185341
134intraciliary transport (GO:0042073)2.85050403
135histone-serine phosphorylation (GO:0035404)2.85032489
136transcription from mitochondrial promoter (GO:0006390)2.84983664
137viral mRNA export from host cell nucleus (GO:0046784)2.84395723
138anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.83821229
139regulation of DNA endoreduplication (GO:0032875)2.82522600
140regulation of centriole replication (GO:0046599)2.81486078
141DNA-dependent DNA replication (GO:0006261)2.81449001
142double-strand break repair via nonhomologous end joining (GO:0006303)2.80209717
143non-recombinational repair (GO:0000726)2.80209717
144histone H2A acetylation (GO:0043968)2.73903460
145* reciprocal DNA recombination (GO:0035825)2.72466802
146* reciprocal meiotic recombination (GO:0007131)2.72466802
147DNA ligation (GO:0006266)2.70272042
148mannosylation (GO:0097502)2.70003506
149rRNA modification (GO:0000154)2.67759849
150retinal cone cell development (GO:0046549)2.66460374
151epithelial cilium movement (GO:0003351)2.66146841
152histone mRNA metabolic process (GO:0008334)2.65774497
153mitotic spindle checkpoint (GO:0071174)2.64379622
154response to X-ray (GO:0010165)2.63944172
155centrosome organization (GO:0051297)2.63450851
156epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.63027245
157mitochondrial RNA metabolic process (GO:0000959)2.61288938
158somatic diversification of immunoglobulins (GO:0016445)2.61147381
159somatic recombination of immunoglobulin gene segments (GO:0016447)2.56842609
160negative regulation of translation, ncRNA-mediated (GO:0040033)2.56755155
161regulation of translation, ncRNA-mediated (GO:0045974)2.56755155
162negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.56755155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.69240504
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.27544280
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.89496936
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.50397792
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.38933075
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07692479
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.80261867
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.71538653
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.69337896
10ZNF274_21170338_ChIP-Seq_K562_Hela2.66252545
11IGF1R_20145208_ChIP-Seq_DFB_Human2.58409133
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57528561
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56773529
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55584773
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.50373567
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43379784
17VDR_22108803_ChIP-Seq_LS180_Human2.43289117
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40774221
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.40290160
20AR_21909140_ChIP-Seq_LNCAP_Human2.37841960
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.32095335
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.31265381
23EWS_26573619_Chip-Seq_HEK293_Human2.26525431
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24262851
25FUS_26573619_Chip-Seq_HEK293_Human2.18700740
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.17720687
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16504631
28XRN2_22483619_ChIP-Seq_HELA_Human2.11446484
29EGR1_19374776_ChIP-ChIP_THP-1_Human2.10889548
30VDR_23849224_ChIP-Seq_CD4+_Human2.08175416
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05809098
32E2F7_22180533_ChIP-Seq_HELA_Human11.1205610
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95094419
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92785682
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91909368
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91768634
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88453112
38FOXP3_21729870_ChIP-Seq_TREG_Human1.86588325
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86034193
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85538079
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84610843
42DCP1A_22483619_ChIP-Seq_HELA_Human1.82052813
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81603228
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80289801
45GBX2_23144817_ChIP-Seq_PC3_Human1.77355034
46P300_19829295_ChIP-Seq_ESCs_Human1.75548639
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73707181
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71390451
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71378934
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70511599
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70240691
52TAF15_26573619_Chip-Seq_HEK293_Human1.70072818
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67601402
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67113958
55ELK1_19687146_ChIP-ChIP_HELA_Human1.66449738
56TTF2_22483619_ChIP-Seq_HELA_Human1.65998184
57GABP_19822575_ChIP-Seq_HepG2_Human1.65746975
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64247023
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62001085
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60756327
61CIITA_25753668_ChIP-Seq_RAJI_Human1.58698180
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57985746
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57810123
64IRF1_19129219_ChIP-ChIP_H3396_Human1.56966847
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56170059
66ER_23166858_ChIP-Seq_MCF-7_Human1.54701320
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54600638
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54429935
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52058665
70MYC_22102868_ChIP-Seq_BL_Human1.45737826
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44867246
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44359780
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43275939
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42810551
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.41116844
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39669595
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39197053
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38988420
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38255925
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35779549
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32448098
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31405782
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29191299
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28839857
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27286082
86TP53_22573176_ChIP-Seq_HFKS_Human1.26650455
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.25983885
88STAT3_23295773_ChIP-Seq_U87_Human1.25571826
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24867023
90KDM5A_27292631_Chip-Seq_BREAST_Human1.24571085
91CBP_20019798_ChIP-Seq_JUKART_Human1.23010490
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23010490
93VDR_21846776_ChIP-Seq_THP-1_Human1.22550152
94YY1_21170310_ChIP-Seq_MESCs_Mouse1.21242589
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20330973
96ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19781861
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19241782
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.18831645
99CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15616648
100TFEB_21752829_ChIP-Seq_HELA_Human1.15308600
101SPI1_23547873_ChIP-Seq_NB4_Human1.14588635
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14051957
103TCF4_23295773_ChIP-Seq_U87_Human1.10613475
104FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09615064
105PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08321535
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07899696
107NANOG_19829295_ChIP-Seq_ESCs_Human1.06921257
108SOX2_19829295_ChIP-Seq_ESCs_Human1.06921257
109MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06804935
110BCAT_22108803_ChIP-Seq_LS180_Human1.06584757
111CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05210153
112SMAD4_21799915_ChIP-Seq_A2780_Human1.05072181
113RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03275122
114GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02640742
115FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02639282
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.02639282
117KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01546937
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00110289
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99939064
120SALL4_22934838_ChIP-ChIP_CD34+_Human0.99843993
121PIAS1_25552417_ChIP-Seq_VCAP_Human0.99785301
122PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97784175
123CRX_20693478_ChIP-Seq_RETINA_Mouse0.97666940
124IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97489518
125TCF4_22108803_ChIP-Seq_LS180_Human0.96627184
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96272099
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94344405
128MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.94297053
129MYC_18940864_ChIP-ChIP_HL60_Human0.94245332
130PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94223091
131CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93791225
132AR_25329375_ChIP-Seq_VCAP_Human0.93249374
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92641851
134CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91976946
135POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91636868
136KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91523091
137FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.91455733
138RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91133816
139SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90288634
140TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89587244
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89506391
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88471515
143CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88462684
144E2F1_18555785_Chip-Seq_ESCs_Mouse0.86473320
145DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83877188
146ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83034610
147POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82132509
148SCL_19346495_ChIP-Seq_HPC-7_Human0.80209229
149BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79842194
150CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78849852
151TP63_19390658_ChIP-ChIP_HaCaT_Human0.77978885
152FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.76922878
153HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76605965
154KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.75862947
155CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75120226
156NOTCH1_21737748_ChIP-Seq_TLL_Human0.74555597
157MYB_26560356_Chip-Seq_TH2_Human0.74514798
158NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.73494618
159IRF8_21731497_ChIP-ChIP_J774_Mouse0.72804170
160GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71730285
161IRF8_22096565_ChIP-ChIP_GC-B_Human0.71484032
162MYB_26560356_Chip-Seq_TH1_Human0.71283459
163DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.71169082
164SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.70408308
165STAT4_19710469_ChIP-ChIP_TH1__Mouse0.70029940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.30308486
2MP0010094_abnormal_chromosome_stability5.18041207
3MP0003111_abnormal_nucleus_morphology4.54965057
4MP0008057_abnormal_DNA_replication4.31326569
5MP0003077_abnormal_cell_cycle4.08625888
6MP0004957_abnormal_blastocyst_morpholog4.04021514
7MP0008058_abnormal_DNA_repair3.31340679
8MP0002396_abnormal_hematopoietic_system3.26760030
9MP0008007_abnormal_cellular_replicative3.15863222
10MP0000372_irregular_coat_pigmentation2.50010596
11MP0003195_calcinosis2.37636390
12MP0006072_abnormal_retinal_apoptosis2.35613916
13MP0008932_abnormal_embryonic_tissue2.31178410
14MP0002938_white_spotting2.27136696
15MP0001730_embryonic_growth_arrest2.12477211
16MP0010307_abnormal_tumor_latency2.10792542
17MP0000350_abnormal_cell_proliferation2.04463183
18MP0003786_premature_aging2.03292084
19MP0000427_abnormal_hair_cycle2.02127124
20MP0008877_abnormal_DNA_methylation1.94565971
21MP0005551_abnormal_eye_electrophysiolog1.92270084
22MP0003123_paternal_imprinting1.84124090
23MP0001545_abnormal_hematopoietic_system1.82073358
24MP0005397_hematopoietic_system_phenotyp1.82073358
25MP0004808_abnormal_hematopoietic_stem1.81203560
26MP0000490_abnormal_crypts_of1.78508940
27MP0005253_abnormal_eye_physiology1.75985597
28MP0008995_early_reproductive_senescence1.75757931
29MP0005084_abnormal_gallbladder_morpholo1.73098408
30MP0010352_gastrointestinal_tract_polyps1.68659335
31MP0003787_abnormal_imprinting1.62464559
32MP0002102_abnormal_ear_morphology1.57920934
33MP0000569_abnormal_digit_pigmentation1.53274572
34MP0002019_abnormal_tumor_incidence1.51296882
35MP0001697_abnormal_embryo_size1.51015013
36MP0001764_abnormal_homeostasis1.49525407
37MP0005380_embryogenesis_phenotype1.46426753
38MP0001672_abnormal_embryogenesis/_devel1.46426753
39MP0001835_abnormal_antigen_presentation1.46034665
40MP0005174_abnormal_tail_pigmentation1.44700267
41MP0003763_abnormal_thymus_physiology1.44042702
42MP0002398_abnormal_bone_marrow1.43219085
43MP0000313_abnormal_cell_death1.42684118
44MP0003567_abnormal_fetal_cardiomyocyte1.40235100
45MP0002080_prenatal_lethality1.39839197
46MP0006035_abnormal_mitochondrial_morpho1.39079761
47MP0003136_yellow_coat_color1.34558483
48MP0003718_maternal_effect1.33963174
49MP0002160_abnormal_reproductive_system1.33345207
50MP0009333_abnormal_splenocyte_physiolog1.31413285
51MP0003984_embryonic_growth_retardation1.31072776
52MP0002088_abnormal_embryonic_growth/wei1.26862735
53MP0009697_abnormal_copulation1.26366323
54MP0003806_abnormal_nucleotide_metabolis1.25358399
55MP0002928_abnormal_bile_duct1.24381117
56MP0000689_abnormal_spleen_morphology1.24222163
57MP0005395_other_phenotype1.21793666
58MP0006054_spinal_hemorrhage1.21335995
59MP0002722_abnormal_immune_system1.21258681
60MP0002095_abnormal_skin_pigmentation1.19615251
61MP0000703_abnormal_thymus_morphology1.19425746
62MP0006292_abnormal_olfactory_placode1.18394320
63MP0005389_reproductive_system_phenotype1.16960286
64MP0004147_increased_porphyrin_level1.16086224
65MP0002086_abnormal_extraembryonic_tissu1.13758158
66MP0002085_abnormal_embryonic_tissue1.13370850
67MP0002429_abnormal_blood_cell1.12645121
68MP0005075_abnormal_melanosome_morpholog1.12016328
69MP0009278_abnormal_bone_marrow1.11527880
70MP0000647_abnormal_sebaceous_gland1.11312941
71MP0000015_abnormal_ear_pigmentation1.09183999
72MP0003121_genomic_imprinting1.06973452
73MP0001986_abnormal_taste_sensitivity1.06132113
74MP0000858_altered_metastatic_potential1.05977791
75MP0000716_abnormal_immune_system1.03398270
76MP0005645_abnormal_hypothalamus_physiol1.03121675
77MP0001853_heart_inflammation1.01605596
78MP0002084_abnormal_developmental_patter1.01295175
79MP0010678_abnormal_skin_adnexa1.01203693
80MP0003698_abnormal_male_reproductive1.00606216
81MP0001529_abnormal_vocalization1.00095194
82MP0003937_abnormal_limbs/digits/tail_de1.00007357
83MP0005076_abnormal_cell_differentiation0.99526351
84MP0004197_abnormal_fetal_growth/weight/0.98553805
85MP0001800_abnormal_humoral_immune0.96909288
86MP0005408_hypopigmentation0.96515734
87MP0002234_abnormal_pharynx_morphology0.93980918
88MP0001984_abnormal_olfaction0.93775621
89MP0001293_anophthalmia0.93344967
90MP0005310_abnormal_salivary_gland0.93127477
91MP0002420_abnormal_adaptive_immunity0.93111753
92MP0002009_preneoplasia0.92277683
93MP0005647_abnormal_sex_gland0.91927475
94MP0002210_abnormal_sex_determination0.91483394
95MP0001819_abnormal_immune_cell0.91453460
96MP0002837_dystrophic_cardiac_calcinosis0.91089024
97MP0002452_abnormal_antigen_presenting0.90840271
98MP0000631_abnormal_neuroendocrine_gland0.90412215
99MP0005171_absent_coat_pigmentation0.88647163
100MP0001324_abnormal_eye_pigmentation0.88643601
101MP0003186_abnormal_redox_activity0.87059347
102MP0005023_abnormal_wound_healing0.86989760
103MP0003950_abnormal_plasma_membrane0.85816459
104MP0000465_gastrointestinal_hemorrhage0.85530333
105MP0000685_abnormal_immune_system0.85380754
106MP0008872_abnormal_physiological_respon0.85235017
107MP0003221_abnormal_cardiomyocyte_apopto0.84167443
108MP0003315_abnormal_perineum_morphology0.82787531
109MP0003878_abnormal_ear_physiology0.81239020
110MP0005377_hearing/vestibular/ear_phenot0.81239020
111MP0003172_abnormal_lysosome_physiology0.81173223
112MP0004043_abnormal_pH_regulation0.81172849
113MP0001119_abnormal_female_reproductive0.80326714
114MP0001145_abnormal_male_reproductive0.79892729
115MP0009785_altered_susceptibility_to0.79878402
116MP0000358_abnormal_cell_content/0.77948394
117MP0005025_abnormal_response_to0.77773912
118MP0002751_abnormal_autonomic_nervous0.77166410
119MP0002638_abnormal_pupillary_reflex0.76867771
120MP0005384_cellular_phenotype0.76504795
121MP0002166_altered_tumor_susceptibility0.76371602
122MP0009765_abnormal_xenobiotic_induced0.76179804
123MP0005248_abnormal_Harderian_gland0.76129220
124MP0002075_abnormal_coat/hair_pigmentati0.75978681
125MP0008789_abnormal_olfactory_epithelium0.75919573
126MP0002090_abnormal_vision0.75840680
127MP0003566_abnormal_cell_adhesion0.75678517
128MP0005379_endocrine/exocrine_gland_phen0.75448491
129MP0005391_vision/eye_phenotype0.75437256
130MP0001915_intracranial_hemorrhage0.75106787
131MP0002405_respiratory_system_inflammati0.75043676
132MP0002138_abnormal_hepatobiliary_system0.74697588
133MP0002723_abnormal_immune_serum0.74239697
134MP0002282_abnormal_trachea_morphology0.73596892
135MP0002006_tumorigenesis0.72626120
136MP0005621_abnormal_cell_physiology0.72387659
137MP0005671_abnormal_response_to0.72106828
138MP0002163_abnormal_gland_morphology0.71845569
139MP0001929_abnormal_gametogenesis0.71821015
140MP0005464_abnormal_platelet_physiology0.71239877
141MP0000371_diluted_coat_color0.70680062
142MP0002419_abnormal_innate_immunity0.70263976
143MP0003943_abnormal_hepatobiliary_system0.70230925
144MP0004133_heterotaxia0.70201264
145MP0002653_abnormal_ependyma_morphology0.69324334
146MP0005220_abnormal_exocrine_pancreas0.69290282
147MP0005646_abnormal_pituitary_gland0.68737045
148MP0005195_abnormal_posterior_eye0.67987671
149MP0000653_abnormal_sex_gland0.66785425
150MP0005266_abnormal_metabolism0.66534137
151MP0002736_abnormal_nociception_after0.66340487
152MP0003890_abnormal_embryonic-extraembry0.65159293
153MP0003436_decreased_susceptibility_to0.63251637
154MP0005000_abnormal_immune_tolerance0.62406095
155MP0001873_stomach_inflammation0.62209628
156MP0006036_abnormal_mitochondrial_physio0.62036109
157MP0000383_abnormal_hair_follicle0.61756089
158MP0009046_muscle_twitch0.61634325
159MP0001186_pigmentation_phenotype0.61034368
160MP0005410_abnormal_fertilization0.59365100

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.65566262
2Chromsome breakage (HP:0040012)4.80535828
3Reticulocytopenia (HP:0001896)4.51585178
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.34373270
5Pancreatic cysts (HP:0001737)4.10246338
6Oral leukoplakia (HP:0002745)3.99745593
7Abnormality of chromosome stability (HP:0003220)3.89611540
8True hermaphroditism (HP:0010459)3.79044408
9Pancreatic fibrosis (HP:0100732)3.66261156
10Abnormal number of erythroid precursors (HP:0012131)3.64187761
11Abnormality of cells of the erythroid lineage (HP:0012130)3.61503621
12Abnormality of the preputium (HP:0100587)3.61231851
13Aplastic anemia (HP:0001915)3.58943731
14Breast hypoplasia (HP:0003187)3.54766109
15Colon cancer (HP:0003003)3.47175381
16Meckel diverticulum (HP:0002245)3.45343771
17Abnormality of the ileum (HP:0001549)3.37819276
18Aplasia/Hypoplasia of the uvula (HP:0010293)3.31287401
19Myelodysplasia (HP:0002863)3.30468999
20Selective tooth agenesis (HP:0001592)3.27330571
21Nephronophthisis (HP:0000090)3.26149351
22Thrombocytosis (HP:0001894)3.13080083
23Medial flaring of the eyebrow (HP:0010747)3.12110619
24Abnormality of midbrain morphology (HP:0002418)3.11643721
25Molar tooth sign on MRI (HP:0002419)3.11643721
26Agnosia (HP:0010524)3.10490933
27Duodenal stenosis (HP:0100867)3.09372743
28Small intestinal stenosis (HP:0012848)3.09372743
29Patellar aplasia (HP:0006443)3.05693533
30Aplasia/Hypoplasia of the tongue (HP:0010295)2.99926695
31Bone marrow hypocellularity (HP:0005528)2.95864958
32Rough bone trabeculation (HP:0100670)2.87981887
3311 pairs of ribs (HP:0000878)2.82162486
34Aplasia/Hypoplasia of the patella (HP:0006498)2.79036270
35Aplasia/Hypoplasia of the tibia (HP:0005772)2.74669739
36Tubulointerstitial nephritis (HP:0001970)2.70821570
37Carpal bone hypoplasia (HP:0001498)2.68619860
38Premature graying of hair (HP:0002216)2.68275550
39Sloping forehead (HP:0000340)2.68041794
40Abnormality of the renal medulla (HP:0100957)2.65191964
41Abnormality of the anterior horn cell (HP:0006802)2.63889157
42Degeneration of anterior horn cells (HP:0002398)2.63889157
43Pallor (HP:0000980)2.61959373
44Microretrognathia (HP:0000308)2.58965983
45Congenital primary aphakia (HP:0007707)2.58301863
46Intestinal atresia (HP:0011100)2.54142989
47Ectopic kidney (HP:0000086)2.53459967
48IgM deficiency (HP:0002850)2.53094160
49Hypoplasia of the capital femoral epiphysis (HP:0003090)2.51513579
50Bile duct proliferation (HP:0001408)2.50074798
51Abnormal biliary tract physiology (HP:0012439)2.50074798
52Chronic hepatic failure (HP:0100626)2.48704032
53Duplicated collecting system (HP:0000081)2.48202059
54Abnormality of the renal cortex (HP:0011035)2.48118898
55Cellular immunodeficiency (HP:0005374)2.47317264
56Postaxial foot polydactyly (HP:0001830)2.44789899
57Clubbing of toes (HP:0100760)2.43291863
58Abnormality of the duodenum (HP:0002246)2.42141415
59Absent thumb (HP:0009777)2.42134460
60Nephrogenic diabetes insipidus (HP:0009806)2.40592910
61Renal cortical cysts (HP:0000803)2.40577529
62Abnormal number of incisors (HP:0011064)2.39295277
63Abnormal lung lobation (HP:0002101)2.37780483
64Gait imbalance (HP:0002141)2.37677068
65Abnormality of the carotid arteries (HP:0005344)2.35797825
66Volvulus (HP:0002580)2.35067245
67Lymphoma (HP:0002665)2.34382489
68Macrocytic anemia (HP:0001972)2.34114321
69Medulloblastoma (HP:0002885)2.33666087
70Abnormality of the renal collecting system (HP:0004742)2.33289312
71Short tibia (HP:0005736)2.30650665
72High pitched voice (HP:0001620)2.30135508
73Impulsivity (HP:0100710)2.26383279
74Hepatocellular necrosis (HP:0001404)2.25268441
75Slender long bone (HP:0003100)2.24696842
76Tracheoesophageal fistula (HP:0002575)2.23608407
77Neoplasm of the pancreas (HP:0002894)2.23340661
78Albinism (HP:0001022)2.22188209
79Hepatic necrosis (HP:0002605)2.22156751
80Cystic liver disease (HP:0006706)2.21305957
81Increased CSF lactate (HP:0002490)2.20213796
82Increased nuchal translucency (HP:0010880)2.19537340
83Pancytopenia (HP:0001876)2.19374603
84Ependymoma (HP:0002888)2.19221913
85Mitochondrial inheritance (HP:0001427)2.16906891
86Amaurosis fugax (HP:0100576)2.16314540
87Abnormality of DNA repair (HP:0003254)2.16276797
88Attenuation of retinal blood vessels (HP:0007843)2.12211233
89Acute myeloid leukemia (HP:0004808)2.10590743
90Genital tract atresia (HP:0001827)2.10114362
91Nephroblastoma (Wilms tumor) (HP:0002667)2.06490594
92Absent radius (HP:0003974)2.05942675
93Congenital hepatic fibrosis (HP:0002612)2.03339303
94Pulmonary fibrosis (HP:0002206)2.02401883
95Abnormal trabecular bone morphology (HP:0100671)2.02081382
96Cafe-au-lait spot (HP:0000957)2.01334478
97Prominent nose (HP:0000448)2.01211646
98Leukopenia (HP:0001882)2.01011732
993-Methylglutaconic aciduria (HP:0003535)2.00927442
100Astigmatism (HP:0000483)1.99052352
101Sclerocornea (HP:0000647)1.98274088
102Abnormality of macular pigmentation (HP:0008002)1.98170931
103Cerebral hypomyelination (HP:0006808)1.97581108
104Anencephaly (HP:0002323)1.97309123
105Triphalangeal thumb (HP:0001199)1.97115360
106Vaginal atresia (HP:0000148)1.95739531
107Congenital stationary night blindness (HP:0007642)1.94440035
108Embryonal renal neoplasm (HP:0011794)1.93736776
109Thyroiditis (HP:0100646)1.93091169
110Rhabdomyosarcoma (HP:0002859)1.93021278
111Gaze-evoked nystagmus (HP:0000640)1.92719538
112Acute necrotizing encephalopathy (HP:0006965)1.92244778
113Abnormality of pyrimidine metabolism (HP:0004353)1.92137691
114Abolished electroretinogram (ERG) (HP:0000550)1.92079529
115Abnormality of reticulocytes (HP:0004312)1.91046811
116Preaxial hand polydactyly (HP:0001177)1.90119891
117Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.89991004
118Increased hepatocellular lipid droplets (HP:0006565)1.89929900
119Hypoplasia of the pons (HP:0012110)1.89691752
120Horseshoe kidney (HP:0000085)1.89152933
121Atresia of the external auditory canal (HP:0000413)1.88741687
122Type I transferrin isoform profile (HP:0003642)1.88580819
123Cleft eyelid (HP:0000625)1.88418084
124Abnormality of the pons (HP:0007361)1.87641809
125Absent forearm bone (HP:0003953)1.87519005
126Aplasia involving forearm bones (HP:0009822)1.87519005
127Poor head control (HP:0002421)1.86802138
128Congenital, generalized hypertrichosis (HP:0004540)1.86710512
129Abnormal protein glycosylation (HP:0012346)1.85878966
130Abnormal glycosylation (HP:0012345)1.85878966
131Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85878966
132Abnormal protein N-linked glycosylation (HP:0012347)1.85878966
133Recurrent abscess formation (HP:0002722)1.85874271
134Short thumb (HP:0009778)1.85739305
135Proximal placement of thumb (HP:0009623)1.84759401
136Severe combined immunodeficiency (HP:0004430)1.84559814
137Microvesicular hepatic steatosis (HP:0001414)1.83489890
138Severe visual impairment (HP:0001141)1.83390310
139Oligodactyly (hands) (HP:0001180)1.83169187
140Poor coordination (HP:0002370)1.82880555
141Deviation of the thumb (HP:0009603)1.82859503
142Abnormality of the heme biosynthetic pathway (HP:0010472)1.82813768
143Supernumerary spleens (HP:0009799)1.82597320
144Renal hypoplasia (HP:0000089)1.81957758
145Methylmalonic acidemia (HP:0002912)1.81868954
146Optic nerve coloboma (HP:0000588)1.81378830
147Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.80869625
148Absent epiphyses (HP:0010577)1.80869625
149Neoplasm of the colon (HP:0100273)1.80106638
150Recurrent viral infections (HP:0004429)1.79606277
151Lipid accumulation in hepatocytes (HP:0006561)1.79447029
152Aplasia/Hypoplasia of the sternum (HP:0006714)1.78655059
153B lymphocytopenia (HP:0010976)1.78347056
154Abnormality of B cell number (HP:0010975)1.78347056
155Increased serum lactate (HP:0002151)1.77003727
156Dandy-Walker malformation (HP:0001305)1.76503012
157Tubular atrophy (HP:0000092)1.75921457
158Progressive macrocephaly (HP:0004481)1.75545787
159Male pseudohermaphroditism (HP:0000037)1.75033071
160Elevated erythrocyte sedimentation rate (HP:0003565)1.74984619
161Type 2 muscle fiber atrophy (HP:0003554)1.74866536
162Progressive inability to walk (HP:0002505)1.74469327
163Postaxial hand polydactyly (HP:0001162)1.74400167
164Acute encephalopathy (HP:0006846)1.74100888
165Basal cell carcinoma (HP:0002671)1.73698408
166Abnormal rod and cone electroretinograms (HP:0008323)1.73420911
167Furrowed tongue (HP:0000221)1.72527437
168Abnormality of the labia minora (HP:0012880)1.72025076
169Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.71789306
170Muscle fiber atrophy (HP:0100295)1.71554493
171Abnormality of the prostate (HP:0008775)1.70965630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.00084512
2FRK4.98269090
3BUB14.76190508
4WEE14.46247348
5MAP4K23.47934692
6NEK23.24469678
7NUAK13.16976109
8SRPK12.58340596
9EIF2AK12.55625326
10NEK12.45277670
11INSRR2.41440786
12BMPR1B2.41079447
13CCNB12.36903885
14BRSK22.24396924
15VRK12.22841478
16ACVR1B2.22458628
17TTK2.22061402
18MST42.10459483
19EIF2AK32.01569134
20PASK1.99594436
21ATR1.97413113
22AURKB1.96929492
23PLK11.93500729
24MKNK11.91641708
25WNK31.90952032
26VRK21.88326991
27PLK41.82944978
28CDK71.74045938
29STK161.74005218
30BRSK11.66820884
31RPS6KA41.63643276
32TRIM281.61762633
33NME21.61411360
34GRK11.61231544
35STK101.49507057
36CDK41.44738824
37TNIK1.44388033
38STK41.42783384
39CHEK21.38586888
40TSSK61.36905047
41TAOK31.36013902
42NME11.34827147
43TESK21.32555872
44MAP3K81.29783388
45ADRBK21.29754319
46PLK31.26202865
47AURKA1.23197975
48TLK11.21995239
49MKNK21.20347244
50RPS6KB21.20338484
51MAP3K41.19513286
52TXK1.16746331
53SCYL21.12963674
54CHEK11.09103922
55MAP4K11.07923858
56ZAK1.06963081
57TGFBR11.06505896
58PLK21.06179023
59DYRK31.04904068
60MAPK131.04722622
61CLK11.03559480
62KIT1.00718652
63PIK3CG0.95919768
64TEC0.95615214
65EIF2AK20.92522067
66FLT30.88512474
67STK390.88011937
68PIM10.86734966
69OXSR10.86473783
70ATM0.85668451
71PAK40.84511633
72PIM20.83050024
73BTK0.82310142
74LRRK20.82138901
75EEF2K0.80242983
76FGFR20.80042296
77CDK20.75652065
78CDK80.73499360
79KDR0.73101822
80MUSK0.70488001
81JAK30.67838735
82IKBKB0.67796405
83STK38L0.66287171
84MELK0.66161951
85BMPR20.63200123
86CSNK2A10.63087226
87IKBKE0.62338167
88CDK60.61939075
89PKN20.60058293
90CDK10.59934137
91CDK120.59878603
92NEK90.59653342
93PINK10.57959200
94PDK20.57918516
95RPS6KA50.55761420
96PRKCE0.55702133
97IRAK40.55580084
98CSNK2A20.54732021
99TYK20.54472403
100CSNK1G10.53855880
101PAK10.53678811
102TESK10.52065379
103PBK0.50976521
104FER0.50365776
105STK30.49814071
106MAPKAPK50.49737346
107DAPK10.48829465
108STK240.47557508
109PTK2B0.46786749
110MAP3K100.46521731
111MARK30.45462503
112BRD40.45121824
113CAMK1D0.45022056
114CAMK1G0.44935900
115PKN10.44001700
116CSNK1G30.43681045
117CSNK1A1L0.43582251
118CSF1R0.41354021
119ILK0.40533306
120TNK20.39999842
121LYN0.39487419
122ZAP700.38763758
123CSNK1G20.37468159
124ADRBK10.35713699
125CSNK1D0.35298399
126IRAK10.34838332
127YES10.34742787
128SYK0.34440655
129CDK190.33252272
130RPS6KA60.32819202
131CHUK0.31603986
132TAF10.31212502
133ALK0.31134393
134MAP2K30.30924740
135CDK30.30864286
136BRAF0.30801134
137TRPM70.30690240
138CASK0.30604287
139PRKAA20.29745116
140RPS6KL10.29589541
141RPS6KC10.29589541
142PRKDC0.28789561
143TIE10.28329403
144NLK0.28189384
145BCKDK0.22671179
146MAPKAPK20.22394221
147AKT20.22294834
148OBSCN0.21810361
149ERBB30.20290950
150BLK0.19728984
151LCK0.19051423
152TTN0.18012400
153PAK20.17485744

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.96963449
2Mismatch repair_Homo sapiens_hsa034304.89449390
3Base excision repair_Homo sapiens_hsa034103.49999722
4* Homologous recombination_Homo sapiens_hsa034403.40740846
5Nucleotide excision repair_Homo sapiens_hsa034203.06450480
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.98272540
7Cell cycle_Homo sapiens_hsa041102.96537967
8Ribosome_Homo sapiens_hsa030102.93897862
9Spliceosome_Homo sapiens_hsa030402.93003037
10One carbon pool by folate_Homo sapiens_hsa006702.70784502
11RNA transport_Homo sapiens_hsa030132.68769426
12Proteasome_Homo sapiens_hsa030502.64526182
13Non-homologous end-joining_Homo sapiens_hsa034502.56179762
14Fanconi anemia pathway_Homo sapiens_hsa034602.55360769
15Pyrimidine metabolism_Homo sapiens_hsa002402.49694897
16RNA polymerase_Homo sapiens_hsa030202.48269404
17Propanoate metabolism_Homo sapiens_hsa006402.37520613
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05301888
19Butanoate metabolism_Homo sapiens_hsa006502.03326066
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00050096
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.98694892
22RNA degradation_Homo sapiens_hsa030181.96646572
23Oxidative phosphorylation_Homo sapiens_hsa001901.79501808
24p53 signaling pathway_Homo sapiens_hsa041151.63094614
25Basal transcription factors_Homo sapiens_hsa030221.48700799
26Systemic lupus erythematosus_Homo sapiens_hsa053221.38282973
27mRNA surveillance pathway_Homo sapiens_hsa030151.34043606
28Purine metabolism_Homo sapiens_hsa002301.32047611
29Peroxisome_Homo sapiens_hsa041461.25914706
30Nitrogen metabolism_Homo sapiens_hsa009101.18891758
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17513150
32Phototransduction_Homo sapiens_hsa047441.14437739
33Fatty acid elongation_Homo sapiens_hsa000621.13732367
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04348697
35Epstein-Barr virus infection_Homo sapiens_hsa051691.04306680
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.03623283
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.00372317
38Pentose phosphate pathway_Homo sapiens_hsa000300.96479746
39Viral carcinogenesis_Homo sapiens_hsa052030.94954521
40Antigen processing and presentation_Homo sapiens_hsa046120.94252068
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92783044
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92466781
43Herpes simplex infection_Homo sapiens_hsa051680.91836781
44Linoleic acid metabolism_Homo sapiens_hsa005910.91596083
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90336414
46Oocyte meiosis_Homo sapiens_hsa041140.90310846
47Tryptophan metabolism_Homo sapiens_hsa003800.88602005
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87953029
49Primary immunodeficiency_Homo sapiens_hsa053400.85736564
50Olfactory transduction_Homo sapiens_hsa047400.84731455
51Biosynthesis of amino acids_Homo sapiens_hsa012300.83589836
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83570126
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79928911
54Fatty acid metabolism_Homo sapiens_hsa012120.76919012
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76614745
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.75214870
57HTLV-I infection_Homo sapiens_hsa051660.75023412
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75001461
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.68599166
60Alzheimers disease_Homo sapiens_hsa050100.67650936
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.66775687
62Small cell lung cancer_Homo sapiens_hsa052220.66458151
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65899911
64Folate biosynthesis_Homo sapiens_hsa007900.64729997
65Steroid biosynthesis_Homo sapiens_hsa001000.64624289
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63971988
67Legionellosis_Homo sapiens_hsa051340.63856997
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63445132
69Protein export_Homo sapiens_hsa030600.59839931
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59834233
71Glutathione metabolism_Homo sapiens_hsa004800.59688402
72Ether lipid metabolism_Homo sapiens_hsa005650.58877398
73Measles_Homo sapiens_hsa051620.58779003
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58633369
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58568495
76MicroRNAs in cancer_Homo sapiens_hsa052060.58360329
77Selenocompound metabolism_Homo sapiens_hsa004500.58001758
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57600998
79Pyruvate metabolism_Homo sapiens_hsa006200.56864685
80Chemical carcinogenesis_Homo sapiens_hsa052040.56848494
81N-Glycan biosynthesis_Homo sapiens_hsa005100.54906851
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54843922
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54678369
84Carbon metabolism_Homo sapiens_hsa012000.54452205
85Caffeine metabolism_Homo sapiens_hsa002320.53314806
86beta-Alanine metabolism_Homo sapiens_hsa004100.50961474
87Apoptosis_Homo sapiens_hsa042100.50051168
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.48373779
89Regulation of autophagy_Homo sapiens_hsa041400.44177558
90Hedgehog signaling pathway_Homo sapiens_hsa043400.43963225
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43949302
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43442753
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42840797
94Hepatitis B_Homo sapiens_hsa051610.42115755
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41930716
96Fatty acid degradation_Homo sapiens_hsa000710.41568299
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41310338
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.41292562
99Shigellosis_Homo sapiens_hsa051310.40219777
100Circadian rhythm_Homo sapiens_hsa047100.39159524
101Arachidonic acid metabolism_Homo sapiens_hsa005900.38471967
102Thyroid cancer_Homo sapiens_hsa052160.38304812
103Type I diabetes mellitus_Homo sapiens_hsa049400.37322426
104Galactose metabolism_Homo sapiens_hsa000520.36700217
105Fructose and mannose metabolism_Homo sapiens_hsa000510.36534928
106Hematopoietic cell lineage_Homo sapiens_hsa046400.36067742
107Alcoholism_Homo sapiens_hsa050340.35865567
108Retinol metabolism_Homo sapiens_hsa008300.35802060
109Huntingtons disease_Homo sapiens_hsa050160.35543749
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.35352225
111Sulfur metabolism_Homo sapiens_hsa009200.33912372
112Taste transduction_Homo sapiens_hsa047420.33428899
113Influenza A_Homo sapiens_hsa051640.33328855
114ABC transporters_Homo sapiens_hsa020100.32165740
115Renin-angiotensin system_Homo sapiens_hsa046140.31741483
116Viral myocarditis_Homo sapiens_hsa054160.30973025
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30549524
118Asthma_Homo sapiens_hsa053100.29693881
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29630382
120Vitamin B6 metabolism_Homo sapiens_hsa007500.29456552
121Glycerolipid metabolism_Homo sapiens_hsa005610.29447800
122Leishmaniasis_Homo sapiens_hsa051400.28863448
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28588958
124Chronic myeloid leukemia_Homo sapiens_hsa052200.28179267
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28038413
126Sulfur relay system_Homo sapiens_hsa041220.28036821
127Autoimmune thyroid disease_Homo sapiens_hsa053200.27637545
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26342176
129B cell receptor signaling pathway_Homo sapiens_hsa046620.26173312
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25824799
131Parkinsons disease_Homo sapiens_hsa050120.25735843
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25086888
133HIF-1 signaling pathway_Homo sapiens_hsa040660.24908990
134Colorectal cancer_Homo sapiens_hsa052100.24233906
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23593969
136Lysine degradation_Homo sapiens_hsa003100.20225982
137Metabolic pathways_Homo sapiens_hsa011000.18559481
138TGF-beta signaling pathway_Homo sapiens_hsa043500.18137733
139Non-small cell lung cancer_Homo sapiens_hsa052230.16406319
140Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16368172
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16227377
142Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15276891
143Bladder cancer_Homo sapiens_hsa052190.14941809
144Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14858651
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.14704244
146Allograft rejection_Homo sapiens_hsa053300.14143003
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.13951735
148Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.13629010
149Leukocyte transendothelial migration_Homo sapiens_hsa046700.12881666
150Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.12565227

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