RAD51C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.64289960
2energy coupled proton transport, down electrochemical gradient (GO:0015985)4.30741965
3ATP synthesis coupled proton transport (GO:0015986)4.30741965
4telomere maintenance via semi-conservative replication (GO:0032201)4.20328031
5DNA replication initiation (GO:0006270)4.12295347
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.12105053
7DNA replication checkpoint (GO:0000076)4.00794400
8protein complex biogenesis (GO:0070271)4.00621919
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.97222127
10mitochondrial respiratory chain complex I assembly (GO:0032981)3.97222127
11NADH dehydrogenase complex assembly (GO:0010257)3.97222127
12chromatin remodeling at centromere (GO:0031055)3.96833098
13mitochondrial respiratory chain complex assembly (GO:0033108)3.96561724
14DNA strand elongation involved in DNA replication (GO:0006271)3.96370803
15protein K6-linked ubiquitination (GO:0085020)3.96029776
16DNA ligation (GO:0006266)3.94769454
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.92605804
18kinetochore assembly (GO:0051382)3.89783351
19telomere maintenance via recombination (GO:0000722)3.89651408
20kinetochore organization (GO:0051383)3.89058620
21DNA strand elongation (GO:0022616)3.83754948
22DNA methylation involved in gamete generation (GO:0043046)3.82997689
23CENP-A containing nucleosome assembly (GO:0034080)3.81337932
24pseudouridine synthesis (GO:0001522)3.74610781
25regulation of double-strand break repair via homologous recombination (GO:0010569)3.74126421
26replication fork processing (GO:0031297)3.73291408
27mitotic recombination (GO:0006312)3.71481928
28electron transport chain (GO:0022900)3.65921763
29respiratory electron transport chain (GO:0022904)3.65159262
30rRNA modification (GO:0000154)3.63469515
31chaperone-mediated protein transport (GO:0072321)3.59410386
32ribosomal small subunit assembly (GO:0000028)3.57799915
33meiotic chromosome segregation (GO:0045132)3.51437289
34cytochrome complex assembly (GO:0017004)3.49246228
35maturation of SSU-rRNA (GO:0030490)3.46903974
36termination of RNA polymerase III transcription (GO:0006386)3.45334332
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.45334332
38DNA deamination (GO:0045006)3.42508685
39microtubule depolymerization (GO:0007019)3.39948218
40ribosomal large subunit biogenesis (GO:0042273)3.37759088
41telomere maintenance via telomere lengthening (GO:0010833)3.31943009
42proteasome assembly (GO:0043248)3.31850851
43piRNA metabolic process (GO:0034587)3.31511497
44mitotic metaphase plate congression (GO:0007080)3.29027292
45negative regulation of DNA-dependent DNA replication (GO:2000104)3.28049892
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.24518996
47regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.24138430
48intra-S DNA damage checkpoint (GO:0031573)3.20733594
49protein-cofactor linkage (GO:0018065)3.20098381
50behavioral response to nicotine (GO:0035095)3.19841327
51viral transcription (GO:0019083)3.19389411
52DNA synthesis involved in DNA repair (GO:0000731)3.17378319
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.16300164
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.16300164
55water-soluble vitamin biosynthetic process (GO:0042364)3.16160516
56histone exchange (GO:0043486)3.15785604
57peptidyl-histidine modification (GO:0018202)3.14793132
58synapsis (GO:0007129)3.13885364
59mitochondrial RNA metabolic process (GO:0000959)3.13555395
60DNA double-strand break processing (GO:0000729)3.12438574
61DNA replication-independent nucleosome assembly (GO:0006336)3.11974491
62DNA replication-independent nucleosome organization (GO:0034724)3.11974491
63regulation of mitochondrial translation (GO:0070129)3.10806134
64rRNA methylation (GO:0031167)3.06941225
65ribosomal small subunit biogenesis (GO:0042274)3.06645854
66metaphase plate congression (GO:0051310)3.06308348
67translational termination (GO:0006415)3.04880110
68protein neddylation (GO:0045116)3.04104922
69DNA catabolic process, exonucleolytic (GO:0000738)3.03850844
70spliceosomal snRNP assembly (GO:0000387)3.03371668
71transcription-coupled nucleotide-excision repair (GO:0006283)3.03059654
72DNA replication-dependent nucleosome assembly (GO:0006335)3.02926830
73DNA replication-dependent nucleosome organization (GO:0034723)3.02926830
74maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.02612831
75L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.02006196
76tRNA processing (GO:0008033)3.00071740
77* recombinational repair (GO:0000725)2.98297314
78negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97335280
79* double-strand break repair via homologous recombination (GO:0000724)2.97250593
80centriole assembly (GO:0098534)2.95155310
81regulation of nuclear cell cycle DNA replication (GO:0033262)2.93500099
82mismatch repair (GO:0006298)2.92268839
83ubiquinone biosynthetic process (GO:0006744)2.86654701
84regulation of centriole replication (GO:0046599)2.86320798
85DNA damage response, detection of DNA damage (GO:0042769)2.86151925
86regulation of pigment cell differentiation (GO:0050932)2.85565651
87regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82302719
88somatic hypermutation of immunoglobulin genes (GO:0016446)2.81235508
89somatic diversification of immune receptors via somatic mutation (GO:0002566)2.81235508
90cullin deneddylation (GO:0010388)2.81235501
91positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.80979375
92cellular component biogenesis (GO:0044085)2.79708310
93respiratory chain complex IV assembly (GO:0008535)2.79685612
94nucleobase biosynthetic process (GO:0046112)2.78201077
95SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.77118656
96protein targeting to mitochondrion (GO:0006626)2.76954364
97protein deneddylation (GO:0000338)2.76758529
98ubiquinone metabolic process (GO:0006743)2.76600152
99deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.75824100
100anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.74300021
101kynurenine metabolic process (GO:0070189)2.74242941
102intracellular protein transmembrane import (GO:0044743)2.71309012
103establishment of protein localization to mitochondrion (GO:0072655)2.71142532
104establishment of chromosome localization (GO:0051303)2.70602909
105attachment of spindle microtubules to kinetochore (GO:0008608)2.70332334
106base-excision repair, AP site formation (GO:0006285)2.69898141
107cotranslational protein targeting to membrane (GO:0006613)2.69343587
108resolution of meiotic recombination intermediates (GO:0000712)2.68277880
109tRNA metabolic process (GO:0006399)2.67883235
110RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.67277860
111ribonucleoprotein complex biogenesis (GO:0022613)2.66870806
112protein targeting to ER (GO:0045047)2.66152190
113negative regulation of ligase activity (GO:0051352)2.64680281
114negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.64680281
115platelet dense granule organization (GO:0060155)2.64380959
116protein localization to mitochondrion (GO:0070585)2.63926800
117translation (GO:0006412)2.63873595
118regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.63195066
119regulation of mitotic spindle checkpoint (GO:1903504)2.63195066
120cellular ketone body metabolic process (GO:0046950)2.62435022
121signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.62292687
122signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.62292687
123signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.62292687
124regulation of helicase activity (GO:0051095)2.62241305
125DNA-dependent DNA replication (GO:0006261)2.62141192
126spliceosomal complex assembly (GO:0000245)2.61261546
127regulation of meiosis I (GO:0060631)2.61050829
128telomere maintenance (GO:0000723)2.59450533
129protein heterotetramerization (GO:0051290)2.58286086
130telomere organization (GO:0032200)2.58191150
131centriole replication (GO:0007099)2.58058080
132rRNA processing (GO:0006364)2.57845700
133regulation of double-strand break repair (GO:2000779)2.57412951
1347-methylguanosine mRNA capping (GO:0006370)2.55850588
135exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.54760502
136RNA capping (GO:0036260)2.54068588
1377-methylguanosine RNA capping (GO:0009452)2.54068588
138DNA replication (GO:0006260)2.53766156
139spindle checkpoint (GO:0031577)2.53314185
140regulation of DNA endoreduplication (GO:0032875)2.52811551
141translational elongation (GO:0006414)2.52796845
142* reciprocal DNA recombination (GO:0035825)2.52728416
143* reciprocal meiotic recombination (GO:0007131)2.52728416
144rRNA metabolic process (GO:0016072)2.52516683
145maturation of 5.8S rRNA (GO:0000460)2.52108781
146DNA strand renaturation (GO:0000733)2.51036805
147nucleotide-excision repair (GO:0006289)2.50894374
148translational initiation (GO:0006413)2.50434511
149GTP biosynthetic process (GO:0006183)2.49680011
150nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.49385651
151DNA methylation (GO:0006306)2.48601880
152DNA alkylation (GO:0006305)2.48601880
153GMP metabolic process (GO:0046037)2.48031747
154establishment of protein localization to endoplasmic reticulum (GO:0072599)2.47991574
155tRNA methylation (GO:0030488)2.47803870
156negative regulation of mitotic sister chromatid separation (GO:2000816)2.45337307
157negative regulation of mitotic sister chromatid segregation (GO:0033048)2.45337307
158negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.45337307
159negative regulation of sister chromatid segregation (GO:0033046)2.45337307
160nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.45142658
161cellular protein complex disassembly (GO:0043624)2.45106284
162protein localization to endoplasmic reticulum (GO:0070972)2.44958907
163meiotic cell cycle (GO:0051321)2.44289351
164negative regulation of chromosome segregation (GO:0051985)2.44131154
165regulation of mitotic metaphase/anaphase transition (GO:0030071)2.43024222
166regulation of DNA-dependent DNA replication (GO:0090329)2.42586147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.40555352
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.97206184
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.61812844
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.37674432
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.37513374
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.33884023
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.32679261
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.79264084
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.73843508
10ZNF274_21170338_ChIP-Seq_K562_Hela2.69602039
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.59240755
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.48598953
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.47719783
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44494197
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.44284234
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.42580985
17VDR_22108803_ChIP-Seq_LS180_Human2.33485374
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32904595
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.32432937
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.23874063
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.22873807
22* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18328387
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15781904
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.10374809
25* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.05073131
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98030325
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.97456937
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.93519501
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.93518736
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92905988
31* VDR_23849224_ChIP-Seq_CD4+_Human1.89538281
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.84959177
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80983901
34FOXP3_21729870_ChIP-Seq_TREG_Human1.80766072
35ELK1_19687146_ChIP-ChIP_HELA_Human1.80666887
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73043934
37TTF2_22483619_ChIP-Seq_HELA_Human1.71322441
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.67743372
39IRF1_19129219_ChIP-ChIP_H3396_Human1.61437763
40* DCP1A_22483619_ChIP-Seq_HELA_Human1.61129847
41EZH2_22144423_ChIP-Seq_EOC_Human1.60286752
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59837555
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.55916396
44* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55744135
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53368874
46* XRN2_22483619_ChIP-Seq_HELA_Human1.53036643
47* ER_23166858_ChIP-Seq_MCF-7_Human1.51918332
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50067045
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48723767
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48628570
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46690418
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45194621
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41120659
54* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40277862
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39961907
56* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39110950
57* SRF_21415370_ChIP-Seq_HL-1_Mouse1.38532936
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37983437
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.37485574
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37123266
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36800005
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35753699
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34982211
64MYC_18940864_ChIP-ChIP_HL60_Human1.34906177
65* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33729369
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33464352
67* TP53_22573176_ChIP-Seq_HFKS_Human1.32496403
68KDM5A_27292631_Chip-Seq_BREAST_Human1.29716303
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27645196
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26991466
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24126774
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23145487
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22514395
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20566644
75GABP_19822575_ChIP-Seq_HepG2_Human1.19541790
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19346319
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19076166
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19060015
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18231281
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17535741
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16427788
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15909671
83AR_21909140_ChIP-Seq_LNCAP_Human1.11548558
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09474745
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08587246
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07306767
87FOXA1_25329375_ChIP-Seq_VCAP_Human1.04601534
88FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04601534
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.04251772
90EWS_26573619_Chip-Seq_HEK293_Human1.02798376
91FUS_26573619_Chip-Seq_HEK293_Human1.01840274
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01338103
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01233786
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00789632
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00181725
96TAF15_26573619_Chip-Seq_HEK293_Human0.99770891
97IGF1R_20145208_ChIP-Seq_DFB_Human0.99485473
98RNF2_27304074_Chip-Seq_NSC_Mouse0.98707623
99P300_19829295_ChIP-Seq_ESCs_Human0.97441014
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96062032
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95718665
102KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94654152
103NMYC_18555785_Chip-Seq_ESCs_Mouse0.94575792
104NCOR_22424771_ChIP-Seq_293T_Human0.93789298
105HOXB7_26014856_ChIP-Seq_BT474_Human0.93061686
106GBX2_23144817_ChIP-Seq_PC3_Human0.92034386
107SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92005065
108STAT3_18555785_Chip-Seq_ESCs_Mouse0.91452834
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88714099
110SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87861436
111P300_18555785_Chip-Seq_ESCs_Mouse0.86995325
112P53_22387025_ChIP-Seq_ESCs_Mouse0.85842056
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85557303
114* AR_20517297_ChIP-Seq_VCAP_Human0.85457608
115OCT4_18555785_Chip-Seq_ESCs_Mouse0.84490394
116E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83943817
117ZFX_18555785_Chip-Seq_ESCs_Mouse0.83832801
118E2F1_18555785_Chip-Seq_ESCs_Mouse0.83491194
119GATA3_21878914_ChIP-Seq_MCF-7_Human0.82873769
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.82518824
121ELK1_22589737_ChIP-Seq_MCF10A_Human0.82346341
122HTT_18923047_ChIP-ChIP_STHdh_Human0.82088081
123SOX2_19829295_ChIP-Seq_ESCs_Human0.81820193
124NANOG_19829295_ChIP-Seq_ESCs_Human0.81820193
125RUNX1_27457419_Chip-Seq_LIVER_Mouse0.81769634
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.81002214
127NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80859993
128* TDRD3_21172665_ChIP-Seq_MCF-7_Human0.79198435
129SALL1_21062744_ChIP-ChIP_HESCs_Human0.79196668
130NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.78502655
131KLF4_18555785_Chip-Seq_ESCs_Mouse0.77672318
132CIITA_25753668_ChIP-Seq_RAJI_Human0.77404786
133TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75976290
134BMI1_23680149_ChIP-Seq_NPCS_Mouse0.75641592
135ESRRB_18555785_Chip-Seq_ESCs_Mouse0.75080875
136CRX_20693478_ChIP-Seq_RETINA_Mouse0.74624644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.86636602
2MP0003136_yellow_coat_color4.63947029
3MP0001188_hyperpigmentation4.27252879
4MP0006292_abnormal_olfactory_placode3.77997827
5MP0010094_abnormal_chromosome_stability3.39054796
6MP0005409_darkened_coat_color3.33799911
7MP0003693_abnormal_embryo_hatching3.10443373
8MP0008058_abnormal_DNA_repair2.75667483
9MP0000566_synostosis2.65651643
10MP0003111_abnormal_nucleus_morphology2.48098090
11MP0005174_abnormal_tail_pigmentation2.44354481
12MP0000015_abnormal_ear_pigmentation2.39026205
13MP0008877_abnormal_DNA_methylation2.38926504
14MP0008057_abnormal_DNA_replication2.24364859
15MP0003077_abnormal_cell_cycle2.17335097
16MP0004957_abnormal_blastocyst_morpholog2.12654743
17MP0005646_abnormal_pituitary_gland2.08371504
18MP0002837_dystrophic_cardiac_calcinosis1.99964751
19MP0003806_abnormal_nucleotide_metabolis1.95003854
20MP0008007_abnormal_cellular_replicative1.94681591
21MP0003786_premature_aging1.93567380
22MP0008932_abnormal_embryonic_tissue1.83019329
23MP0002102_abnormal_ear_morphology1.78316575
24MP0003646_muscle_fatigue1.73913374
25* MP0002210_abnormal_sex_determination1.71760665
26MP0006036_abnormal_mitochondrial_physio1.71147489
27MP0005551_abnormal_eye_electrophysiolog1.70203648
28MP0008872_abnormal_physiological_respon1.70032158
29MP0004381_abnormal_hair_follicle1.70005827
30MP0003718_maternal_effect1.69242881
31MP0000049_abnormal_middle_ear1.67222589
32MP0002938_white_spotting1.66596873
33MP0005645_abnormal_hypothalamus_physiol1.66053307
34MP0002163_abnormal_gland_morphology1.65492082
35MP0001986_abnormal_taste_sensitivity1.63318763
36MP0001529_abnormal_vocalization1.62644516
37MP0003195_calcinosis1.61325557
38MP0002736_abnormal_nociception_after1.58452060
39MP0002095_abnormal_skin_pigmentation1.57825613
40MP0000490_abnormal_crypts_of1.54267116
41MP0002249_abnormal_larynx_morphology1.51304372
42MP0002277_abnormal_respiratory_mucosa1.49424254
43MP0000372_irregular_coat_pigmentation1.48903717
44MP0008789_abnormal_olfactory_epithelium1.48713227
45MP0005084_abnormal_gallbladder_morpholo1.48545096
46MP0008875_abnormal_xenobiotic_pharmacok1.48329395
47MP0006035_abnormal_mitochondrial_morpho1.45172400
48MP0001968_abnormal_touch/_nociception1.38056072
49MP0003941_abnormal_skin_development1.37871076
50MP0010030_abnormal_orbit_morphology1.37337511
51MP0002876_abnormal_thyroid_physiology1.36706417
52MP0005253_abnormal_eye_physiology1.36058357
53MP0009046_muscle_twitch1.35930755
54MP0002177_abnormal_outer_ear1.35384939
55* MP0001929_abnormal_gametogenesis1.34173015
56MP0003315_abnormal_perineum_morphology1.33226746
57MP0000427_abnormal_hair_cycle1.31741497
58MP0002638_abnormal_pupillary_reflex1.29376751
59MP0000678_abnormal_parathyroid_gland1.28738194
60MP0005083_abnormal_biliary_tract1.26065860
61* MP0001145_abnormal_male_reproductive1.25292763
62MP0002234_abnormal_pharynx_morphology1.22389683
63MP0003880_abnormal_central_pattern1.21149059
64MP0003186_abnormal_redox_activity1.21106695
65MP0003123_paternal_imprinting1.20533193
66MP0004142_abnormal_muscle_tone1.20369577
67MP0002751_abnormal_autonomic_nervous1.17644331
68* MP0000653_abnormal_sex_gland1.16534325
69MP0004133_heterotaxia1.16359919
70MP0009745_abnormal_behavioral_response1.15712013
71MP0009333_abnormal_splenocyte_physiolog1.14198788
72MP0003787_abnormal_imprinting1.13751062
73MP0003011_delayed_dark_adaptation1.13096603
74MP0004145_abnormal_muscle_electrophysio1.09104172
75* MP0001119_abnormal_female_reproductive1.08529339
76MP0008260_abnormal_autophagy1.07922283
77MP0002132_abnormal_respiratory_system1.07845511
78MP0005257_abnormal_intraocular_pressure1.04506625
79MP0003938_abnormal_ear_development1.04135006
80MP0000681_abnormal_thyroid_gland1.03524633
81* MP0003698_abnormal_male_reproductive1.03518794
82MP0005171_absent_coat_pigmentation1.03425615
83MP0002653_abnormal_ependyma_morphology1.01650984
84MP0001186_pigmentation_phenotype0.99356136
85MP0000631_abnormal_neuroendocrine_gland0.98258367
86* MP0002160_abnormal_reproductive_system0.98069207
87MP0005379_endocrine/exocrine_gland_phen0.97942037
88MP0003121_genomic_imprinting0.97360684
89MP0002075_abnormal_coat/hair_pigmentati0.96710427
90MP0003763_abnormal_thymus_physiology0.96120747
91MP0002396_abnormal_hematopoietic_system0.96085650
92MP0005408_hypopigmentation0.95957845
93MP0005394_taste/olfaction_phenotype0.94257519
94MP0005499_abnormal_olfactory_system0.94257519
95MP0003937_abnormal_limbs/digits/tail_de0.93993709
96MP0002272_abnormal_nervous_system0.93179513
97MP0000350_abnormal_cell_proliferation0.92112004
98MP0001764_abnormal_homeostasis0.90753935
99MP0002928_abnormal_bile_duct0.89414807
100* MP0005389_reproductive_system_phenotype0.89105142
101MP0004885_abnormal_endolymph0.88600559
102MP0000647_abnormal_sebaceous_gland0.87943477
103MP0000383_abnormal_hair_follicle0.85374486
104MP0001905_abnormal_dopamine_level0.85150850
105MP0000569_abnormal_digit_pigmentation0.83915905
106MP0001485_abnormal_pinna_reflex0.83712152
107MP0002735_abnormal_chemical_nociception0.81110545
108MP0005266_abnormal_metabolism0.80993095
109MP0001293_anophthalmia0.80499026
110MP0004215_abnormal_myocardial_fiber0.80338740
111MP0003252_abnormal_bile_duct0.80234212
112MP0000026_abnormal_inner_ear0.79790823
113MP0009697_abnormal_copulation0.79498515
114MP0000313_abnormal_cell_death0.79150188
115MP0009250_abnormal_appendicular_skeleto0.78145781
116MP0004043_abnormal_pH_regulation0.76812307
117MP0002019_abnormal_tumor_incidence0.76519575
118MP0001324_abnormal_eye_pigmentation0.75976031
119MP0005332_abnormal_amino_acid0.75840799
120MP0001835_abnormal_antigen_presentation0.75444300
121MP0003755_abnormal_palate_morphology0.74405587
122MP0003385_abnormal_body_wall0.74393762
123MP0000358_abnormal_cell_content/0.73485715
124MP0008995_early_reproductive_senescence0.72730446
125MP0005410_abnormal_fertilization0.72412881
126* MP0001919_abnormal_reproductive_system0.71925334
127MP0006276_abnormal_autonomic_nervous0.71310954
128MP0005195_abnormal_posterior_eye0.71299225
129MP0000613_abnormal_salivary_gland0.70753337
130MP0005075_abnormal_melanosome_morpholog0.69061007
131MP0002085_abnormal_embryonic_tissue0.68667857
132MP0001286_abnormal_eye_development0.68632835
133MP0003890_abnormal_embryonic-extraembry0.66512779
134MP0002184_abnormal_innervation0.66463488
135MP0003283_abnormal_digestive_organ0.65804748
136MP0004742_abnormal_vestibular_system0.65271482
137MP0002148_abnormal_hypersensitivity_rea0.65180611
138MP0006072_abnormal_retinal_apoptosis0.64540129
139MP0004147_increased_porphyrin_level0.64514333
140MP0002398_abnormal_bone_marrow0.63077463
141MP0004808_abnormal_hematopoietic_stem0.62657018
142MP0002009_preneoplasia0.61484435
143MP0000432_abnormal_head_morphology0.60947668
144MP0002116_abnormal_craniofacial_bone0.60610157
145* MP0002161_abnormal_fertility/fecundity0.59887740
146MP0005671_abnormal_response_to0.59740034
147MP0000689_abnormal_spleen_morphology0.58825556
148MP0000703_abnormal_thymus_morphology0.58575166
149MP0003936_abnormal_reproductive_system0.57783627
150MP0002722_abnormal_immune_system0.54628585

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.42534817
2Chromsome breakage (HP:0040012)4.37352219
3Acute necrotizing encephalopathy (HP:0006965)4.08635467
4Type I transferrin isoform profile (HP:0003642)3.86135426
5Abnormal mitochondria in muscle tissue (HP:0008316)3.69799025
6Mitochondrial inheritance (HP:0001427)3.69569469
7Acute encephalopathy (HP:0006846)3.65823569
8Increased CSF lactate (HP:0002490)3.64138846
9Progressive macrocephaly (HP:0004481)3.46682456
10Birth length less than 3rd percentile (HP:0003561)3.45445793
11Reticulocytopenia (HP:0001896)3.39407846
12Reduced antithrombin III activity (HP:0001976)3.13107246
13Hepatocellular necrosis (HP:0001404)3.09774351
14Lipid accumulation in hepatocytes (HP:0006561)3.09648286
15* Meckel diverticulum (HP:0002245)3.09034126
16Hepatic necrosis (HP:0002605)3.05930192
17* Abnormality of the ileum (HP:0001549)2.97255692
18Abnormality of alanine metabolism (HP:0010916)2.97122271
19Hyperalaninemia (HP:0003348)2.97122271
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.97122271
21Supernumerary spleens (HP:0009799)2.97050731
22Impulsivity (HP:0100710)2.92945202
23* Abnormality of the preputium (HP:0100587)2.91642520
24* Aplasia/Hypoplasia of the uvula (HP:0010293)2.90983922
25* Abnormality of chromosome stability (HP:0003220)2.87149242
26Increased serum lactate (HP:0002151)2.81761364
27True hermaphroditism (HP:0010459)2.76008163
28Ectopic kidney (HP:0000086)2.74402558
29Abnormal sex determination (HP:0012244)2.69364650
30Sex reversal (HP:0012245)2.69364650
31Renal Fanconi syndrome (HP:0001994)2.67873461
32Abnormality of cells of the erythroid lineage (HP:0012130)2.65118905
33Capillary hemangiomas (HP:0005306)2.64584202
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.63971133
35Type II lissencephaly (HP:0007260)2.63020636
36Cerebral edema (HP:0002181)2.58749823
37Abnormal lung lobation (HP:0002101)2.57989421
38Microvesicular hepatic steatosis (HP:0001414)2.57654693
39Abnormal number of erythroid precursors (HP:0012131)2.57383674
40Patellar aplasia (HP:0006443)2.56563863
41Pancreatic cysts (HP:0001737)2.56228375
42Pancreatic fibrosis (HP:0100732)2.54452305
43Pendular nystagmus (HP:0012043)2.50248181
44Abnormality of the phalanges of the hallux (HP:0010057)2.48797230
45Lactic acidosis (HP:0003128)2.44540227
46Aplasia/Hypoplasia of the patella (HP:0006498)2.42956075
47Aplasia/hypoplasia of the uterus (HP:0008684)2.40985074
48* Triphalangeal thumb (HP:0001199)2.40942699
49Nephronophthisis (HP:0000090)2.39452948
50Congenital, generalized hypertrichosis (HP:0004540)2.37210117
51Abnormality of the renal cortex (HP:0011035)2.36847495
52Decreased activity of mitochondrial respiratory chain (HP:0008972)2.36755299
53Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.36755299
5411 pairs of ribs (HP:0000878)2.34446714
553-Methylglutaconic aciduria (HP:0003535)2.31810086
56Congenital stationary night blindness (HP:0007642)2.30261547
57Aplastic anemia (HP:0001915)2.29406877
58Nephroblastoma (Wilms tumor) (HP:0002667)2.27272994
59Renal cortical cysts (HP:0000803)2.22819072
60* Clubbing of toes (HP:0100760)2.22568647
61Facial hemangioma (HP:0000329)2.22364257
62Median cleft lip (HP:0000161)2.21875898
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21854636
64Abnormal protein N-linked glycosylation (HP:0012347)2.21854636
65Abnormal protein glycosylation (HP:0012346)2.21854636
66Abnormal glycosylation (HP:0012345)2.21854636
67* Duodenal stenosis (HP:0100867)2.21343911
68* Small intestinal stenosis (HP:0012848)2.21343911
69Aplasia/Hypoplasia of the fovea (HP:0008060)2.21236802
70Hypoplasia of the fovea (HP:0007750)2.21236802
71Increased intramyocellular lipid droplets (HP:0012240)2.21027708
72Optic disc pallor (HP:0000543)2.20075459
73Breast hypoplasia (HP:0003187)2.19550700
74Abnormality of DNA repair (HP:0003254)2.17114190
75Methylmalonic acidemia (HP:0002912)2.14349759
76Embryonal renal neoplasm (HP:0011794)2.13546550
77Severe visual impairment (HP:0001141)2.12631970
78Colon cancer (HP:0003003)2.11893712
79Abnormality of the pons (HP:0007361)2.10330294
80Abnormality of midbrain morphology (HP:0002418)2.09550043
81Molar tooth sign on MRI (HP:0002419)2.09550043
82Preaxial hand polydactyly (HP:0001177)2.08306525
83Respiratory failure (HP:0002878)2.08278514
84Lethargy (HP:0001254)2.06959189
85Attenuation of retinal blood vessels (HP:0007843)2.05367364
86Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05221300
87Concave nail (HP:0001598)2.05108802
88Optic nerve hypoplasia (HP:0000609)2.05032858
89Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04839856
90Septo-optic dysplasia (HP:0100842)2.04669204
91* Absent thumb (HP:0009777)2.03254996
92Abnormality of the renal collecting system (HP:0004742)2.02289793
93Pallor (HP:0000980)2.01837565
94Macrocytic anemia (HP:0001972)2.01571580
95Hypoplasia of the pons (HP:0012110)2.01566120
96Medulloblastoma (HP:0002885)2.01459193
97Aplasia/Hypoplasia of the tongue (HP:0010295)2.00370618
98Methylmalonic aciduria (HP:0012120)1.99271322
99Exertional dyspnea (HP:0002875)1.98404391
100Abnormality of the renal medulla (HP:0100957)1.98295500
101Furrowed tongue (HP:0000221)1.97623173
102Congenital sensorineural hearing impairment (HP:0008527)1.96550535
103Anencephaly (HP:0002323)1.96430953
104Cleft eyelid (HP:0000625)1.95213446
105Dynein arm defect of respiratory motile cilia (HP:0012255)1.95190536
106Absent/shortened dynein arms (HP:0200106)1.95190536
107Oligodactyly (HP:0012165)1.94486789
108* Sloping forehead (HP:0000340)1.93423416
109Absent radius (HP:0003974)1.92551440
110Adrenal hypoplasia (HP:0000835)1.92207623
111Abolished electroretinogram (ERG) (HP:0000550)1.91541166
112Aplasia involving forearm bones (HP:0009822)1.88876013
113Absent forearm bone (HP:0003953)1.88876013
114* Aganglionic megacolon (HP:0002251)1.88367472
115Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.87927903
116Abnormality of the labia minora (HP:0012880)1.87469468
117Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.86863355
118Increased hepatocellular lipid droplets (HP:0006565)1.86769631
119Leukodystrophy (HP:0002415)1.86151826
120Duplicated collecting system (HP:0000081)1.86125259
121Progressive microcephaly (HP:0000253)1.85544095
122Abnormal respiratory motile cilium morphology (HP:0005938)1.84806442
123Abnormal respiratory epithelium morphology (HP:0012253)1.84806442
124Medial flaring of the eyebrow (HP:0010747)1.84367040
125Abnormality of the septum pellucidum (HP:0007375)1.84184188
126* Bone marrow hypocellularity (HP:0005528)1.83232644
127Abnormal spermatogenesis (HP:0008669)1.82839346
128Agnosia (HP:0010524)1.82411848
129Rib fusion (HP:0000902)1.81914112
130Abnormal rod and cone electroretinograms (HP:0008323)1.81513845
131* Abnormality of the carotid arteries (HP:0005344)1.81241661
132Cystic liver disease (HP:0006706)1.81072605
133* Myelodysplasia (HP:0002863)1.80555267
134Exercise intolerance (HP:0003546)1.80549247
135Pancytopenia (HP:0001876)1.80451629
136Male pseudohermaphroditism (HP:0000037)1.79958134
137Large for gestational age (HP:0001520)1.79560592
138Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78907094
139Hypothermia (HP:0002045)1.76477647
140Microglossia (HP:0000171)1.75728640
141Sclerocornea (HP:0000647)1.75687415
142Split foot (HP:0001839)1.75467677
143Retinal dysplasia (HP:0007973)1.75242347
144* Abnormality of the duodenum (HP:0002246)1.74555499
145Absent septum pellucidum (HP:0001331)1.74479781
146Abnormal number of incisors (HP:0011064)1.73862613
147Abnormal ciliary motility (HP:0012262)1.73649146
148Ketoacidosis (HP:0001993)1.72916560
149Aplasia/Hypoplasia of the tibia (HP:0005772)1.72716807
150Increased muscle lipid content (HP:0009058)1.71442171
151Microretrognathia (HP:0000308)1.70813286
152Congenital primary aphakia (HP:0007707)1.69861571
153Abnormality of renal resorption (HP:0011038)1.68293858

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK24.02249492
2CASK3.66039589
3TLK13.39661742
4FRK3.33244077
5VRK23.31756475
6SRPK13.07691254
7TNIK3.00055045
8CDC72.98873008
9MKNK12.84497076
10NME22.63464818
11WEE12.56433425
12STK162.47721169
13BUB12.33120820
14CLK12.30786924
15EIF2AK12.29795549
16IRAK32.19132229
17NEK12.09206642
18PLK42.06557434
19PNCK1.94024667
20MST41.89472964
21MAP4K21.85947908
22VRK11.83911198
23PASK1.77741209
24EIF2AK31.76927065
25ZAK1.75519389
26WNK31.74882508
27NLK1.73349656
28IRAK41.70590850
29YES11.64614664
30TRIM281.53912022
31TTK1.53854893
32PLK11.52073743
33NEK21.49033987
34ACVR1B1.47095270
35NME11.46794245
36TXK1.38612615
37WNK41.38369911
38EIF2AK21.37907547
39TAF11.34981910
40BRAF1.31728754
41DYRK31.27170633
42CHEK21.26499101
43CDK71.25533897
44PRPF4B1.19777327
45IRAK11.19321070
46BRSK21.18773462
47STK391.16743921
48CDK81.16252083
49AKT31.15058791
50ATR1.15049579
51BRD41.12984801
52AURKB1.11887199
53BLK1.09602594
54PBK1.08652576
55STK38L1.02634233
56PIM21.00943180
57TEC1.00813080
58OXSR10.99059738
59IRAK20.97278761
60BCKDK0.93579786
61TAOK30.92650872
62PLK30.91343234
63CDK30.88898816
64CAMKK20.87588107
65BMPR20.87449006
66RPS6KB20.86404780
67CCNB10.86370437
68NUAK10.81791416
69STK40.78763649
70AURKA0.78497394
71MAP2K70.77848017
72ADRBK20.77792244
73RPS6KA40.77204184
74PIM10.75252407
75MAPK130.75113766
76PIK3CA0.74020355
77PLK20.72131720
78NEK90.70863529
79GRK10.70315910
80MAPKAPK30.67484059
81FES0.66785375
82MUSK0.66540916
83PRKCG0.66436847
84MAP3K40.65855317
85CSNK1G30.64789026
86ATM0.63654442
87DYRK20.63224899
88PDK20.62825567
89CSNK2A10.62254683
90PRKD20.62118580
91CDK90.62017241
92NEK60.61227140
93BMPR1B0.60251375
94CHEK10.59377500
95MAPKAPK50.56901379
96MAP3K120.56241559
97CDK40.55847569
98ERBB30.53827535
99CSNK1G20.52996631
100CDK120.52463933
101ADRBK10.52190667
102CDK190.51309811
103TGFBR10.48400074
104EPHB20.48057875
105PRKCE0.47765641
106MAPK110.47228744
107CSNK1A1L0.46256888
108BTK0.46207678
109CSNK2A20.45007219
110MAP3K140.44424058
111LYN0.43992908
112RPS6KA50.43696837
113SIK30.43337490
114CDK20.41982471
115BRSK10.40470382
116DAPK10.39608578
117PAK30.37948027
118CDK10.36632904
119KIT0.34849416
120SCYL20.33978649
121CSNK1A10.33915675
122MARK30.33291597
123IKBKB0.33230816
124STK30.32634987
125INSRR0.31478364
126STK380.28561152
127STK240.28332604
128CSNK1D0.25381875
129CAMK2A0.24894854
130CSNK1E0.24822273
131CHUK0.24273446
132PRKACA0.23942325
133PRKCI0.22810554
134PAK10.22026608
135TSSK60.21108192
136CSNK1G10.19357448
137AKT10.18298593
138MELK0.18253746
139FLT30.18115314
140MAPK140.17773179
141PINK10.17111400

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.36756738
2Mismatch repair_Homo sapiens_hsa034303.83249499
3* Homologous recombination_Homo sapiens_hsa034403.42476632
4Ribosome_Homo sapiens_hsa030103.41306679
5RNA polymerase_Homo sapiens_hsa030203.21257377
6* Fanconi anemia pathway_Homo sapiens_hsa034603.19535165
7Basal transcription factors_Homo sapiens_hsa030222.76076678
8Spliceosome_Homo sapiens_hsa030402.73471397
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.70761470
10Nucleotide excision repair_Homo sapiens_hsa034202.68336798
11Base excision repair_Homo sapiens_hsa034102.61324062
12Cell cycle_Homo sapiens_hsa041102.43557354
13Pyrimidine metabolism_Homo sapiens_hsa002402.36984141
14Non-homologous end-joining_Homo sapiens_hsa034502.13675752
15Proteasome_Homo sapiens_hsa030502.05889756
16One carbon pool by folate_Homo sapiens_hsa006702.05412538
17RNA transport_Homo sapiens_hsa030132.04925830
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.97096141
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82477628
20RNA degradation_Homo sapiens_hsa030181.79117911
21Protein export_Homo sapiens_hsa030601.75637471
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.73561362
23p53 signaling pathway_Homo sapiens_hsa041151.68976498
24Purine metabolism_Homo sapiens_hsa002301.59945417
25Selenocompound metabolism_Homo sapiens_hsa004501.55816702
26Butanoate metabolism_Homo sapiens_hsa006501.46770828
27Cardiac muscle contraction_Homo sapiens_hsa042601.37279523
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29416945
29Propanoate metabolism_Homo sapiens_hsa006401.27830521
30Nitrogen metabolism_Homo sapiens_hsa009101.20487716
31Herpes simplex infection_Homo sapiens_hsa051681.18783449
32mRNA surveillance pathway_Homo sapiens_hsa030151.12269527
33Tryptophan metabolism_Homo sapiens_hsa003801.11092504
34Other glycan degradation_Homo sapiens_hsa005111.08207166
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06943001
36Sulfur relay system_Homo sapiens_hsa041221.06753767
37Phototransduction_Homo sapiens_hsa047441.04763068
38Systemic lupus erythematosus_Homo sapiens_hsa053221.04518323
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01509701
40Epstein-Barr virus infection_Homo sapiens_hsa051691.00708256
41Intestinal immune network for IgA production_Homo sapiens_hsa046720.93055990
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92500914
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91124969
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.91078218
45Huntingtons disease_Homo sapiens_hsa050160.88771683
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87626488
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86229822
48Pyruvate metabolism_Homo sapiens_hsa006200.85782062
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85625502
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.84937496
51Basal cell carcinoma_Homo sapiens_hsa052170.84199918
52Olfactory transduction_Homo sapiens_hsa047400.83955440
53Arachidonic acid metabolism_Homo sapiens_hsa005900.83330004
54Primary immunodeficiency_Homo sapiens_hsa053400.82168212
55Measles_Homo sapiens_hsa051620.81759249
56Thyroid cancer_Homo sapiens_hsa052160.81449960
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81366861
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81270243
59Peroxisome_Homo sapiens_hsa041460.79227411
60Folate biosynthesis_Homo sapiens_hsa007900.78687931
61Caffeine metabolism_Homo sapiens_hsa002320.78152337
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77701598
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76754181
64Steroid biosynthesis_Homo sapiens_hsa001000.74658397
65Fatty acid elongation_Homo sapiens_hsa000620.73392628
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72654715
67Sulfur metabolism_Homo sapiens_hsa009200.69527118
68Allograft rejection_Homo sapiens_hsa053300.69099639
69Hematopoietic cell lineage_Homo sapiens_hsa046400.68140225
70Graft-versus-host disease_Homo sapiens_hsa053320.67120994
71Nicotine addiction_Homo sapiens_hsa050330.66703263
72Regulation of autophagy_Homo sapiens_hsa041400.65291865
73Wnt signaling pathway_Homo sapiens_hsa043100.63365386
74Oxidative phosphorylation_Homo sapiens_hsa001900.62545021
75HTLV-I infection_Homo sapiens_hsa051660.60946355
76Autoimmune thyroid disease_Homo sapiens_hsa053200.60905387
77Sphingolipid metabolism_Homo sapiens_hsa006000.57563339
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57029268
79Oocyte meiosis_Homo sapiens_hsa041140.56783305
80Parkinsons disease_Homo sapiens_hsa050120.56601553
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55948177
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55740477
83Alcoholism_Homo sapiens_hsa050340.55605315
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55230258
85Asthma_Homo sapiens_hsa053100.54326055
86Chemical carcinogenesis_Homo sapiens_hsa052040.54046898
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53946486
88Ether lipid metabolism_Homo sapiens_hsa005650.52621757
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52448237
90Viral carcinogenesis_Homo sapiens_hsa052030.52226423
91N-Glycan biosynthesis_Homo sapiens_hsa005100.51539176
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.48974755
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48524690
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46887968
95Collecting duct acid secretion_Homo sapiens_hsa049660.45298496
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45163068
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44920073
98Taste transduction_Homo sapiens_hsa047420.43552118
99Fatty acid degradation_Homo sapiens_hsa000710.43022878
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42850805
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42806624
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42197869
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.41690756
104Influenza A_Homo sapiens_hsa051640.41476658
105Hedgehog signaling pathway_Homo sapiens_hsa043400.40887716
106Retinol metabolism_Homo sapiens_hsa008300.40441660
107Hepatitis B_Homo sapiens_hsa051610.40435270
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40082025
109beta-Alanine metabolism_Homo sapiens_hsa004100.39230131
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37306202
111Fatty acid metabolism_Homo sapiens_hsa012120.36992540
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.36395502
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36241452
114Antigen processing and presentation_Homo sapiens_hsa046120.36026752
115MicroRNAs in cancer_Homo sapiens_hsa052060.34653638
116Notch signaling pathway_Homo sapiens_hsa043300.34468047
117Prostate cancer_Homo sapiens_hsa052150.33685855
118Colorectal cancer_Homo sapiens_hsa052100.32481999
119Type I diabetes mellitus_Homo sapiens_hsa049400.31782676
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30533768
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28441871
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28038425
123Melanoma_Homo sapiens_hsa052180.27769712
124Leishmaniasis_Homo sapiens_hsa051400.27100754
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27029334
126Pathways in cancer_Homo sapiens_hsa052000.26933150
127Arginine and proline metabolism_Homo sapiens_hsa003300.26705303
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25575249
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25244655
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.24961486
131Malaria_Homo sapiens_hsa051440.23778940
132Acute myeloid leukemia_Homo sapiens_hsa052210.20940485
133Metabolic pathways_Homo sapiens_hsa011000.20926273
134Small cell lung cancer_Homo sapiens_hsa052220.20755614
135ABC transporters_Homo sapiens_hsa020100.19967799
136Vitamin B6 metabolism_Homo sapiens_hsa007500.19582145
137Alzheimers disease_Homo sapiens_hsa050100.19461050
138Morphine addiction_Homo sapiens_hsa050320.19103311
139TGF-beta signaling pathway_Homo sapiens_hsa043500.18925548
140Toll-like receptor signaling pathway_Homo sapiens_hsa046200.18766714
141Apoptosis_Homo sapiens_hsa042100.18103138
142Glutathione metabolism_Homo sapiens_hsa004800.18081831
143Circadian rhythm_Homo sapiens_hsa047100.17297605
144Linoleic acid metabolism_Homo sapiens_hsa005910.16200899
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.16115439
146Fat digestion and absorption_Homo sapiens_hsa049750.14921223

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