RAD54L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.72631920
2nuclear pore complex assembly (GO:0051292)5.45272331
3pre-miRNA processing (GO:0031054)5.34951132
4nuclear pore organization (GO:0006999)5.12572877
5pyrimidine nucleobase catabolic process (GO:0006208)4.65112589
6mitotic sister chromatid cohesion (GO:0007064)4.45246010
7regulation of RNA export from nucleus (GO:0046831)4.15922892
8pore complex assembly (GO:0046931)4.02669042
9DNA deamination (GO:0045006)3.85914446
10heterochromatin organization (GO:0070828)3.85475521
11negative regulation of histone methylation (GO:0031061)3.84098256
12paraxial mesoderm development (GO:0048339)3.81103171
13gamma-aminobutyric acid transport (GO:0015812)3.80596612
14cytoplasmic mRNA processing body assembly (GO:0033962)3.73160423
15dosage compensation (GO:0007549)3.64679178
16DNA double-strand break processing (GO:0000729)3.57563868
17nucleobase catabolic process (GO:0046113)3.55131543
18protein localization to kinetochore (GO:0034501)3.55027504
19DNA unwinding involved in DNA replication (GO:0006268)3.49190859
20histone H2A monoubiquitination (GO:0035518)3.46119158
21neural tube formation (GO:0001841)3.43949209
22negative regulation of transcription regulatory region DNA binding (GO:2000678)3.40170894
23regulation of histone H3-K9 methylation (GO:0051570)3.38285999
24regulation of hippo signaling (GO:0035330)3.36313569
25NLS-bearing protein import into nucleus (GO:0006607)3.32340753
26mitotic nuclear envelope disassembly (GO:0007077)3.31936775
27mRNA stabilization (GO:0048255)3.31749530
28RNA stabilization (GO:0043489)3.31749530
29protein polyglutamylation (GO:0018095)3.30484848
30somite development (GO:0061053)3.29838914
31regulation of nucleobase-containing compound transport (GO:0032239)3.26866843
32chromatin assembly (GO:0031497)3.26589706
33limb bud formation (GO:0060174)3.25779191
34indolalkylamine metabolic process (GO:0006586)3.24351800
35regulation of sister chromatid cohesion (GO:0007063)3.22016988
36DNA duplex unwinding (GO:0032508)3.20799034
37DNA geometric change (GO:0032392)3.19690946
38folic acid-containing compound biosynthetic process (GO:0009396)3.19455598
39presynaptic membrane assembly (GO:0097105)3.17190886
40sister chromatid segregation (GO:0000819)3.17028282
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.17015559
42NADH dehydrogenase complex assembly (GO:0010257)3.17015559
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.17015559
44cell proliferation in forebrain (GO:0021846)3.15750368
45tryptophan catabolic process (GO:0006569)3.14470786
46indole-containing compound catabolic process (GO:0042436)3.14470786
47indolalkylamine catabolic process (GO:0046218)3.14470786
48membrane disassembly (GO:0030397)3.13127559
49nuclear envelope disassembly (GO:0051081)3.13127559
50glucocorticoid receptor signaling pathway (GO:0042921)3.08916945
51sulfation (GO:0051923)3.08321448
52histone H3-K36 demethylation (GO:0070544)3.08305041
53mitotic chromosome condensation (GO:0007076)3.07331110
54protein localization to chromosome, centromeric region (GO:0071459)3.06295842
55negative regulation of DNA repair (GO:0045738)3.05750036
56regulation of gene silencing by miRNA (GO:0060964)3.04921548
57regulation of gene silencing by RNA (GO:0060966)3.04921548
58regulation of posttranscriptional gene silencing (GO:0060147)3.04921548
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.03067312
60kynurenine metabolic process (GO:0070189)3.02264580
61water-soluble vitamin biosynthetic process (GO:0042364)3.00929719
62spinal cord development (GO:0021510)2.93851908
63regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.93679912
64gene silencing by RNA (GO:0031047)2.91589579
65protein localization to chromosome (GO:0034502)2.90952477
66spliceosomal tri-snRNP complex assembly (GO:0000244)2.89800971
67presynaptic membrane organization (GO:0097090)2.89231392
68regulation of translational fidelity (GO:0006450)2.87585855
69protein-cofactor linkage (GO:0018065)2.86931361
70monoubiquitinated protein deubiquitination (GO:0035520)2.85562061
71head development (GO:0060322)2.84935975
72retinal cone cell development (GO:0046549)2.84808636
73histone lysine demethylation (GO:0070076)2.84643604
74regulation of mesoderm development (GO:2000380)2.84494845
75protein complex biogenesis (GO:0070271)2.84065229
76hippo signaling (GO:0035329)2.83939750
77negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.81497351
78piRNA metabolic process (GO:0034587)2.81150872
79negative regulation of synaptic transmission, GABAergic (GO:0032229)2.80902778
80nonmotile primary cilium assembly (GO:0035058)2.80217895
81regulation of chromatin binding (GO:0035561)2.80080386
82peptidyl-lysine dimethylation (GO:0018027)2.79973259
83negative regulation of DNA-dependent DNA replication (GO:2000104)2.79650022
84histone H3-K9 demethylation (GO:0033169)2.79122079
85embryonic retina morphogenesis in camera-type eye (GO:0060059)2.78620908
86negative regulation of telomere maintenance (GO:0032205)2.77339717
87mitotic sister chromatid segregation (GO:0000070)2.76701647
88intracellular estrogen receptor signaling pathway (GO:0030520)2.76286708
89regulation of spindle organization (GO:0090224)2.75688458
90tryptophan metabolic process (GO:0006568)2.74830833
91histone demethylation (GO:0016577)2.74711696
92histone H3-K9 methylation (GO:0051567)2.74267781
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.74170832
94positive regulation of mitotic sister chromatid separation (GO:1901970)2.74152285
95positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.74152285
96positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.74152285
97gene silencing (GO:0016458)2.74041159
98DNA methylation involved in gamete generation (GO:0043046)2.73516137
99RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.72521861
100histone H3-K4 methylation (GO:0051568)2.72067168
101glycine metabolic process (GO:0006544)2.71816756
102corticosteroid receptor signaling pathway (GO:0031958)2.70439423
103mitochondrial respiratory chain complex assembly (GO:0033108)2.70327009
104regulation of mitotic spindle organization (GO:0060236)2.70048013
105fucose catabolic process (GO:0019317)2.69904527
106L-fucose metabolic process (GO:0042354)2.69904527
107L-fucose catabolic process (GO:0042355)2.69904527
108regulation of centriole replication (GO:0046599)2.68590276
109negative regulation of translation, ncRNA-mediated (GO:0040033)2.68568358
110regulation of translation, ncRNA-mediated (GO:0045974)2.68568358
111negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.68568358
112DNA replication-dependent nucleosome assembly (GO:0006335)2.68542528
113DNA replication-dependent nucleosome organization (GO:0034723)2.68542528
114regulation of translational termination (GO:0006449)2.67691151
115regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.67689474
116nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67604201
117regulation of mRNA stability (GO:0043488)2.66646227
118positive regulation of chromosome segregation (GO:0051984)2.66189648
119positive regulation of SMAD protein import into nucleus (GO:0060391)2.63637005
120exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.63587663
121transmission of nerve impulse (GO:0019226)2.63347945
122spinal cord motor neuron differentiation (GO:0021522)2.63302388
123DNA demethylation (GO:0080111)2.62872660
124negative regulation of histone modification (GO:0031057)2.62601974
125nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.61988702
126positive regulation of mitochondrial fission (GO:0090141)2.61753248
127behavioral response to ethanol (GO:0048149)2.61287247
128regulation of mitotic spindle checkpoint (GO:1903504)2.61222864
129regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.61222864
130nucleosome disassembly (GO:0006337)2.61148337
131protein-DNA complex disassembly (GO:0032986)2.61148337
132retinal ganglion cell axon guidance (GO:0031290)2.60371453
133postsynaptic membrane organization (GO:0001941)2.60082988
134trophectodermal cell differentiation (GO:0001829)2.60034436
135olfactory bulb development (GO:0021772)2.59730276
136regulation of DNA endoreduplication (GO:0032875)2.59236067
137indole-containing compound metabolic process (GO:0042430)2.59085075
138response to UV-C (GO:0010225)2.58977056
139replication fork processing (GO:0031297)2.57881214
140positive regulation of histone deacetylation (GO:0031065)2.57565119
141kidney morphogenesis (GO:0060993)2.56545045
142sympathetic nervous system development (GO:0048485)2.54863650
143positive regulation of fatty acid beta-oxidation (GO:0032000)2.54008136
144histone H3-K9 modification (GO:0061647)2.53701355
145regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.53075044
146stress granule assembly (GO:0034063)2.52832687
147regulation of protein polyubiquitination (GO:1902914)2.51886983
148DNA conformation change (GO:0071103)2.51777158
149regulation of telomere maintenance (GO:0032204)2.50663997
150serotonin metabolic process (GO:0042428)2.49652796
151neuron cell-cell adhesion (GO:0007158)2.49373596
152nuclear envelope organization (GO:0006998)2.48934539
153mRNA transport (GO:0051028)2.48884118
154histone H4-K12 acetylation (GO:0043983)2.48850090
155regulation of collateral sprouting (GO:0048670)2.48197481
156chromatin silencing (GO:0006342)2.47843230
157regulation of RNA stability (GO:0043487)2.47819503
158outer ear morphogenesis (GO:0042473)2.47786461
159regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.47609155
160recombinational repair (GO:0000725)2.47202083
161negative regulation of chromatin modification (GO:1903309)2.47067401
162regulation of DNA damage checkpoint (GO:2000001)2.46274286
163regulation of double-strand break repair (GO:2000779)2.45614383
164protein dealkylation (GO:0008214)2.44507810
165protein demethylation (GO:0006482)2.44507810
166double-strand break repair via homologous recombination (GO:0000724)2.43802912
167chromatin assembly or disassembly (GO:0006333)2.43542006
168intraciliary transport (GO:0042073)2.41832657
169DNA integration (GO:0015074)2.41548838
170primary amino compound metabolic process (GO:1901160)2.41498437
171regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.40474919
172regulation of fatty acid beta-oxidation (GO:0031998)2.40382406
173RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.40096519
174tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.40096519
175microtubule anchoring (GO:0034453)2.39283240
176embryonic epithelial tube formation (GO:0001838)2.38537842
177rRNA catabolic process (GO:0016075)2.37982237
178cornea development in camera-type eye (GO:0061303)2.37508884
179DNA modification (GO:0006304)2.37351688
180oxidative demethylation (GO:0070989)2.35903635
181photoreceptor cell development (GO:0042461)2.35557822
182histone H2A acetylation (GO:0043968)2.34783379
183ncRNA catabolic process (GO:0034661)2.34755635
184somatic diversification of immune receptors via somatic mutation (GO:0002566)2.34467923
185somatic hypermutation of immunoglobulin genes (GO:0016446)2.34467923
186DNA damage response, detection of DNA damage (GO:0042769)2.34424310
187reflex (GO:0060004)2.34412296
188preassembly of GPI anchor in ER membrane (GO:0016254)2.33868519
189forebrain neuron differentiation (GO:0021879)2.32722688
190detection of light stimulus involved in visual perception (GO:0050908)2.32550516
191detection of light stimulus involved in sensory perception (GO:0050962)2.32550516
192dendritic spine morphogenesis (GO:0060997)2.32018690

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.58753896
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.75982678
3EZH2_22144423_ChIP-Seq_EOC_Human4.40855849
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.13211593
5ZNF274_21170338_ChIP-Seq_K562_Hela3.60486605
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.26144533
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.17242413
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.05534126
9MYC_22102868_ChIP-Seq_BL_Human3.05034602
10GBX2_23144817_ChIP-Seq_PC3_Human3.02321219
11IGF1R_20145208_ChIP-Seq_DFB_Human2.97987638
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.96185627
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.91698269
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.68618098
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61632139
16VDR_22108803_ChIP-Seq_LS180_Human2.57310717
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55252043
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.53389805
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.38864165
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36975214
21FUS_26573619_Chip-Seq_HEK293_Human2.36765023
22EWS_26573619_Chip-Seq_HEK293_Human2.29005480
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25059208
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25010022
25TAF15_26573619_Chip-Seq_HEK293_Human2.20114669
26E2F1_21310950_ChIP-Seq_MCF-7_Human2.10079121
27IRF1_19129219_ChIP-ChIP_H3396_Human2.09865504
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.06208097
29* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05085021
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02468107
31P300_19829295_ChIP-Seq_ESCs_Human1.91291884
32TCF7_22412390_ChIP-Seq_EML_Mouse1.89938288
33SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.89760444
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89434464
35PPARA_22158963_ChIP-Seq_LIVER_Mouse1.87779006
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85800567
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83266028
38* RXR_22158963_ChIP-Seq_LIVER_Mouse1.82700527
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80161706
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.78807448
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.77626162
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.75789392
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.75170892
44AR_21909140_ChIP-Seq_LNCAP_Human1.71435641
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.68105255
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67869479
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.67409254
48MYC_18940864_ChIP-ChIP_HL60_Human1.67177619
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67045921
50RNF2_27304074_Chip-Seq_NSC_Mouse1.66789061
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.64805096
52MYC_18555785_ChIP-Seq_MESCs_Mouse1.63295669
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61167693
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60931388
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.60347229
56SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.60176573
57* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58913383
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58634603
59KDM2B_26808549_Chip-Seq_DND41_Human1.57011048
60* LXR_22158963_ChIP-Seq_LIVER_Mouse1.56153381
61ZFP281_27345836_Chip-Seq_ESCs_Mouse1.55228051
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54375313
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.54061168
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52936076
65PKCTHETA_26484144_Chip-Seq_BREAST_Human1.52525047
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52403247
67CBP_20019798_ChIP-Seq_JUKART_Human1.52403247
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49750738
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49427256
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48421399
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.48198337
72* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.47186710
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47139637
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46840669
75REST_21632747_ChIP-Seq_MESCs_Mouse1.45607203
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45484777
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45411405
78ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.45024540
79SMAD4_21799915_ChIP-Seq_A2780_Human1.44820406
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.44515477
81ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44230979
82FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44219182
83CIITA_25753668_ChIP-Seq_RAJI_Human1.42227215
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41717514
85* STAT3_23295773_ChIP-Seq_U87_Human1.41376071
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40606327
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40254783
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38968622
89NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38787862
90VDR_21846776_ChIP-Seq_THP-1_Human1.38220758
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37696667
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37696667
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34771478
94* KDM5A_27292631_Chip-Seq_BREAST_Human1.34142814
95PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33835381
96CLOCK_20551151_ChIP-Seq_293T_Human1.33682965
97TCF3_18692474_ChIP-Seq_MESCs_Mouse1.33416759
98* TCF4_23295773_ChIP-Seq_U87_Human1.31946943
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30583444
100ER_23166858_ChIP-Seq_MCF-7_Human1.30099501
101EZH2_27304074_Chip-Seq_ESCs_Mouse1.29118971
102AR_25329375_ChIP-Seq_VCAP_Human1.27332298
103ELK1_19687146_ChIP-ChIP_HELA_Human1.26353479
104SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.26150398
105TCF3_18692474_ChIP-Seq_MEFs_Mouse1.26072987
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.25756202
107P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25513499
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25231876
109NCOR1_26117541_ChIP-Seq_K562_Human1.25007396
110KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24744714
111KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24744714
112KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24744714
113CHD1_26751641_Chip-Seq_LNCaP_Human1.24706604
114MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22303161
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22255106
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22226897
117POU5F1_16518401_ChIP-PET_MESCs_Mouse1.21994088
118EED_16625203_ChIP-ChIP_MESCs_Mouse1.21763555
119PIAS1_25552417_ChIP-Seq_VCAP_Human1.20924159
120OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20836198
121* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20063476
122* UTX_26944678_Chip-Seq_JUKART_Human1.18726839
123ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18196297
124SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17117245
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17001116
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16892998
127* KDM2B_26808549_Chip-Seq_JURKAT_Human1.16605790
128PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16354542
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15925298
130TP53_22573176_ChIP-Seq_HFKS_Human1.15473259
131NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.15145555
132* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15087819
133POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15072636
134DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14718695
135* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14528579
136AR_21572438_ChIP-Seq_LNCaP_Human1.13978440
137* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13506637
138KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13411273
139ELK3_25401928_ChIP-Seq_HUVEC_Human1.12660256
140VDR_23849224_ChIP-Seq_CD4+_Human1.12270576
141KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10396490
142RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10204431
143MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10172731
144NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09938343
145MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09607183
146BCAT_22108803_ChIP-Seq_LS180_Human1.09538180
147NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09336469
148SOX2_16153702_ChIP-ChIP_HESCs_Human1.09143077
149ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08363725
150RUNX2_22187159_ChIP-Seq_PCA_Human1.08075049
151NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07841519
152MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07784414
153NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06258431
154ZNF263_19887448_ChIP-Seq_K562_Human1.06024117
155MAF_26560356_Chip-Seq_TH1_Human1.05563522
156* REST_18959480_ChIP-ChIP_MESCs_Mouse1.05040460
157ETS1_20019798_ChIP-Seq_JURKAT_Human1.04657319
158GATA6_25053715_ChIP-Seq_YYC3_Human1.04330916
159PRDM14_20953172_ChIP-Seq_ESCs_Human1.04239328
160SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04169835
161TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04029393
162ATF3_27146783_Chip-Seq_COLON_Human1.03917697
163EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03581477
164STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03182098
165HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00850751
166RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99672757
167CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98257498
168SMAD4_21741376_ChIP-Seq_EPCs_Human0.97829553
169SOX2_19829295_ChIP-Seq_ESCs_Human0.97596980
170NANOG_19829295_ChIP-Seq_ESCs_Human0.97596980
171JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97464488
172TCF4_22108803_ChIP-Seq_LS180_Human0.97019988
173* MYB_26560356_Chip-Seq_TH1_Human0.96639023
174AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96574900
175TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95115986
176FLI1_21867929_ChIP-Seq_TH2_Mouse0.95043118
177PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94911820
178NFE2_27457419_Chip-Seq_LIVER_Mouse0.94706179
179YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94350035
180TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.93849129
181SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93292032
182TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93275791
183EZH2_27294783_Chip-Seq_NPCs_Mouse0.93275785
184ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92811588
185TAL1_26923725_Chip-Seq_HPCs_Mouse0.92801125
186CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92280718
187SOX2_18692474_ChIP-Seq_MESCs_Mouse0.91559770
188SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91429545
189FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.90896600
190PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90770046
191BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89030112
192FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88319200
193* EGR1_23403033_ChIP-Seq_LIVER_Mouse0.87072391

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.30361127
2MP0003705_abnormal_hypodermis_morpholog3.28335674
3MP0010352_gastrointestinal_tract_polyps2.97759934
4MP0005076_abnormal_cell_differentiation2.82342087
5MP0003111_abnormal_nucleus_morphology2.81049238
6MP0002102_abnormal_ear_morphology2.59097721
7MP0010094_abnormal_chromosome_stability2.40712333
8MP0005360_urolithiasis2.27393609
9MP0003077_abnormal_cell_cycle2.24626508
10MP0009053_abnormal_anal_canal2.20199526
11MP0010307_abnormal_tumor_latency2.16580207
12MP0002139_abnormal_hepatobiliary_system2.13128219
13MP0003890_abnormal_embryonic-extraembry2.10021286
14MP0008057_abnormal_DNA_replication2.09505623
15MP0005365_abnormal_bile_salt2.09248943
16MP0006072_abnormal_retinal_apoptosis2.07427655
17MP0003693_abnormal_embryo_hatching2.05265571
18MP0000631_abnormal_neuroendocrine_gland2.03803654
19MP0008789_abnormal_olfactory_epithelium2.01746918
20MP0000049_abnormal_middle_ear2.01289408
21MP0003252_abnormal_bile_duct1.98310149
22MP0000569_abnormal_digit_pigmentation1.96462801
23* MP0001672_abnormal_embryogenesis/_devel1.90953548
24* MP0005380_embryogenesis_phenotype1.90953548
25MP0001984_abnormal_olfaction1.90472778
26MP0005646_abnormal_pituitary_gland1.90384367
27MP0005394_taste/olfaction_phenotype1.89799033
28MP0005499_abnormal_olfactory_system1.89799033
29MP0003123_paternal_imprinting1.88076861
30MP0004197_abnormal_fetal_growth/weight/1.86367609
31MP0009046_muscle_twitch1.84991331
32MP0001730_embryonic_growth_arrest1.84857675
33MP0002084_abnormal_developmental_patter1.84623740
34MP0004957_abnormal_blastocyst_morpholog1.84257202
35MP0003121_genomic_imprinting1.83181550
36MP0008995_early_reproductive_senescence1.81903994
37MP0000537_abnormal_urethra_morphology1.78383017
38MP0006276_abnormal_autonomic_nervous1.77385077
39MP0001968_abnormal_touch/_nociception1.77112414
40MP0002086_abnormal_extraembryonic_tissu1.76754834
41* MP0002088_abnormal_embryonic_growth/wei1.75590240
42* MP0003984_embryonic_growth_retardation1.74054175
43MP0002272_abnormal_nervous_system1.73801641
44MP0005085_abnormal_gallbladder_physiolo1.73165626
45MP0005551_abnormal_eye_electrophysiolog1.72542050
46MP0000778_abnormal_nervous_system1.71391961
47MP0004133_heterotaxia1.71326990
48MP0001485_abnormal_pinna_reflex1.71155952
49MP0003787_abnormal_imprinting1.69572914
50MP0009745_abnormal_behavioral_response1.69412689
51MP0009672_abnormal_birth_weight1.68674016
52* MP0000350_abnormal_cell_proliferation1.68565444
53MP0003718_maternal_effect1.66731409
54MP0003938_abnormal_ear_development1.64430024
55MP0005253_abnormal_eye_physiology1.62652267
56MP0001529_abnormal_vocalization1.61488766
57MP0001849_ear_inflammation1.60999208
58* MP0002085_abnormal_embryonic_tissue1.60841556
59MP0001293_anophthalmia1.57481760
60MP0003880_abnormal_central_pattern1.56752641
61MP0004885_abnormal_endolymph1.55737982
62MP0004142_abnormal_muscle_tone1.54423995
63MP0009703_decreased_birth_body1.54222916
64MP0002160_abnormal_reproductive_system1.53489837
65MP0002751_abnormal_autonomic_nervous1.52563026
66MP0005187_abnormal_penis_morphology1.50926261
67MP0008058_abnormal_DNA_repair1.50732554
68* MP0001697_abnormal_embryo_size1.50226524
69MP0003646_muscle_fatigue1.50149248
70MP0001486_abnormal_startle_reflex1.49603943
71MP0000733_abnormal_muscle_development1.48320137
72MP0002638_abnormal_pupillary_reflex1.47014413
73MP0010030_abnormal_orbit_morphology1.46596947
74MP0000372_irregular_coat_pigmentation1.46160849
75MP0001986_abnormal_taste_sensitivity1.45390377
76MP0008877_abnormal_DNA_methylation1.44050752
77MP0004264_abnormal_extraembryonic_tissu1.42443000
78MP0002938_white_spotting1.40750631
79MP0004808_abnormal_hematopoietic_stem1.37917499
80MP0003567_abnormal_fetal_cardiomyocyte1.36905605
81MP0000428_abnormal_craniofacial_morphol1.36531654
82MP0002736_abnormal_nociception_after1.36191151
83MP0008007_abnormal_cellular_replicative1.35912762
84MP0002396_abnormal_hematopoietic_system1.35671948
85MP0002092_abnormal_eye_morphology1.35590293
86MP0009278_abnormal_bone_marrow1.33883709
87MP0002234_abnormal_pharynx_morphology1.33529395
88MP0005645_abnormal_hypothalamus_physiol1.31782866
89MP0002697_abnormal_eye_size1.31466579
90MP0002735_abnormal_chemical_nociception1.31432430
91MP0002557_abnormal_social/conspecific_i1.29636350
92MP0004185_abnormal_adipocyte_glucose1.28978994
93MP0004145_abnormal_muscle_electrophysio1.27514240
94* MP0002080_prenatal_lethality1.27361475
95MP0003635_abnormal_synaptic_transmissio1.26489668
96MP0002184_abnormal_innervation1.25818728
97MP0003300_gastrointestinal_ulcer1.25456009
98MP0005389_reproductive_system_phenotype1.24626739
99MP0003115_abnormal_respiratory_system1.23763083
100MP0002064_seizures1.23320100
101MP0002572_abnormal_emotion/affect_behav1.22670948
102MP0003119_abnormal_digestive_system1.21969495
103MP0003122_maternal_imprinting1.21959673
104MP0002876_abnormal_thyroid_physiology1.21143729
105MP0003935_abnormal_craniofacial_develop1.21111967
106MP0003566_abnormal_cell_adhesion1.18467784
107MP0001915_intracranial_hemorrhage1.17789061
108MP0002752_abnormal_somatic_nervous1.16500202
109MP0005248_abnormal_Harderian_gland1.16146678
110MP0003786_premature_aging1.15631557
111MP0003937_abnormal_limbs/digits/tail_de1.15619649
112MP0002063_abnormal_learning/memory/cond1.15216871
113MP0000026_abnormal_inner_ear1.13902100
114MP0010329_abnormal_lipoprotein_level1.08604233
115MP0000432_abnormal_head_morphology1.06119438
116MP0001963_abnormal_hearing_physiology1.05341431
117MP0005423_abnormal_somatic_nervous1.04123152
118MP0010234_abnormal_vibrissa_follicle1.03347031
119MP0001929_abnormal_gametogenesis1.01728872
120MP0000609_abnormal_liver_physiology1.01552418
121MP0002734_abnormal_mechanical_nocicepti1.00140551
122MP0002067_abnormal_sensory_capabilities0.99731283
123MP0002210_abnormal_sex_determination0.99684275
124MP0002837_dystrophic_cardiac_calcinosis0.98856202
125MP0005195_abnormal_posterior_eye0.98385608
126MP0002733_abnormal_thermal_nociception0.98328632
127MP0002925_abnormal_cardiovascular_devel0.97602913
128MP0003195_calcinosis0.97059588
129MP0002882_abnormal_neuron_morphology0.94214574
130MP0003698_abnormal_male_reproductive0.94211236
131MP0004742_abnormal_vestibular_system0.93932140
132MP0008872_abnormal_physiological_respon0.93645056
133MP0003385_abnormal_body_wall0.93394777
134MP0002111_abnormal_tail_morphology0.92662712
135MP0005386_behavior/neurological_phenoty0.92252926
136MP0004924_abnormal_behavior0.92252926
137MP0005391_vision/eye_phenotype0.92234780
138MP0004043_abnormal_pH_regulation0.91825053
139MP0001286_abnormal_eye_development0.91640044
140MP0000955_abnormal_spinal_cord0.90711162
141MP0001440_abnormal_grooming_behavior0.90592996
142MP0005023_abnormal_wound_healing0.90304476
143MP0003136_yellow_coat_color0.89439532
144MP0008961_abnormal_basal_metabolism0.88776221
145MP0001188_hyperpigmentation0.88657132
146MP0005666_abnormal_adipose_tissue0.88562225
147MP0000653_abnormal_sex_gland0.88288496
148MP0009840_abnormal_foam_cell0.88200409
149MP0000490_abnormal_crypts_of0.88159162
150MP0001177_atelectasis0.87307854
151MP0001501_abnormal_sleep_pattern0.87276047
152MP0000647_abnormal_sebaceous_gland0.86154162
153MP0001970_abnormal_pain_threshold0.84800265
154MP0005257_abnormal_intraocular_pressure0.83027151
155MP0008932_abnormal_embryonic_tissue0.82914378
156MP0001145_abnormal_male_reproductive0.82486179
157MP0005397_hematopoietic_system_phenotyp0.82059448
158MP0001545_abnormal_hematopoietic_system0.82059448
159MP0000427_abnormal_hair_cycle0.81969261
160MP0002152_abnormal_brain_morphology0.81917902
161MP0009697_abnormal_copulation0.81723987
162MP0003755_abnormal_palate_morphology0.81700551
163MP0002653_abnormal_ependyma_morphology0.80458323
164* MP0003861_abnormal_nervous_system0.79047476
165MP0002932_abnormal_joint_morphology0.78705049
166MP0000703_abnormal_thymus_morphology0.78206441
167MP0002019_abnormal_tumor_incidence0.77022182
168MP0000598_abnormal_liver_morphology0.76925557
169* MP0000313_abnormal_cell_death0.75951219
170MP0002233_abnormal_nose_morphology0.75594999
171MP0008770_decreased_survivor_rate0.74196272
172MP0000266_abnormal_heart_morphology0.71929838
173MP0002877_abnormal_melanocyte_morpholog0.68186542
174MP0000477_abnormal_intestine_morphology0.67341644
175MP0003091_abnormal_cell_migration0.66763919
176MP0003941_abnormal_skin_development0.66206776
177MP0010678_abnormal_skin_adnexa0.65826101
178MP0003868_abnormal_feces_composition0.65683999
179MP0000371_diluted_coat_color0.64781395
180MP0010630_abnormal_cardiac_muscle0.64095831
181MP0000383_abnormal_hair_follicle0.63578514
182MP0005621_abnormal_cell_physiology0.63025914
183MP0002249_abnormal_larynx_morphology0.62702400

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.85734482
2Pancreatic fibrosis (HP:0100732)3.44286008
3True hermaphroditism (HP:0010459)3.35170813
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.16983882
5Short 4th metacarpal (HP:0010044)3.16983882
6Abolished electroretinogram (ERG) (HP:0000550)3.07073642
7Nephronophthisis (HP:0000090)3.02451901
8Stenosis of the external auditory canal (HP:0000402)3.01162690
9Ependymoma (HP:0002888)3.00829153
10Abnormality of the renal collecting system (HP:0004742)2.99618094
11Abnormality of the fingertips (HP:0001211)2.95845605
12Pendular nystagmus (HP:0012043)2.93296483
13Volvulus (HP:0002580)2.89809438
14Abnormality of midbrain morphology (HP:0002418)2.87297190
15Molar tooth sign on MRI (HP:0002419)2.87297190
16Pseudobulbar signs (HP:0002200)2.86643636
17Medial flaring of the eyebrow (HP:0010747)2.81188485
18Heterotopia (HP:0002282)2.79668355
19Renovascular hypertension (HP:0100817)2.79542560
20Genetic anticipation (HP:0003743)2.79529992
21Astrocytoma (HP:0009592)2.69386377
22Abnormality of the astrocytes (HP:0100707)2.69386377
23Congenital stationary night blindness (HP:0007642)2.67627632
24Increased nuchal translucency (HP:0010880)2.66558592
25Abnormality of the 4th metacarpal (HP:0010012)2.65087145
26Hyperacusis (HP:0010780)2.63181847
27Progressive cerebellar ataxia (HP:0002073)2.61371014
28Abnormality of the renal medulla (HP:0100957)2.53964495
29Long eyelashes (HP:0000527)2.53645118
30Elfin facies (HP:0004428)2.49791285
31Hypochromic microcytic anemia (HP:0004840)2.49014597
32Gait imbalance (HP:0002141)2.48610865
33Renal duplication (HP:0000075)2.44018938
34Chronic hepatic failure (HP:0100626)2.40718679
35Aplasia/Hypoplasia of the tibia (HP:0005772)2.40019768
36Broad-based gait (HP:0002136)2.38368239
37Congenital primary aphakia (HP:0007707)2.37922702
38Hyperventilation (HP:0002883)2.37230044
39Medulloblastoma (HP:0002885)2.37098501
40Aplasia/Hypoplasia of the patella (HP:0006498)2.34607348
41Abnormality of the renal cortex (HP:0011035)2.32217789
42Methylmalonic acidemia (HP:0002912)2.31268308
43Glioma (HP:0009733)2.31110210
44Nephrogenic diabetes insipidus (HP:0009806)2.30220728
45Deep venous thrombosis (HP:0002625)2.29395336
46Supernumerary ribs (HP:0005815)2.28995140
47Deviation of the thumb (HP:0009603)2.27413135
48Subacute progressive viral hepatitis (HP:0006572)2.27325769
49Shallow orbits (HP:0000586)2.25518396
50Proximal placement of thumb (HP:0009623)2.23865551
51Cystic liver disease (HP:0006706)2.21907894
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.20659109
53Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20619723
54Sclerocornea (HP:0000647)2.19216674
55Vaginal atresia (HP:0000148)2.18403210
56Genital tract atresia (HP:0001827)2.17899683
57Trigonocephaly (HP:0000243)2.17860320
58Anal stenosis (HP:0002025)2.17377146
59Cutis marmorata (HP:0000965)2.16872829
60Morphological abnormality of the middle ear (HP:0008609)2.16665930
61Ectopic kidney (HP:0000086)2.15538068
62Oligodactyly (hands) (HP:0001180)2.14008355
63Facial hemangioma (HP:0000329)2.13049923
64Drooling (HP:0002307)2.12918554
65Inability to walk (HP:0002540)2.12252046
66Neoplasm of the oral cavity (HP:0100649)2.11579274
67Abnormality of the lower motor neuron (HP:0002366)2.11467572
68Short tibia (HP:0005736)2.10790055
69Gaze-evoked nystagmus (HP:0000640)2.10239142
70Thyroid-stimulating hormone excess (HP:0002925)2.10115994
71Abnormality of DNA repair (HP:0003254)2.08785591
72Neoplasm of striated muscle (HP:0009728)2.08635212
73Rhabdomyosarcoma (HP:0002859)2.08340520
74Malignant gastrointestinal tract tumors (HP:0006749)2.06737812
75Gastrointestinal carcinoma (HP:0002672)2.06737812
76Abnormality of cochlea (HP:0000375)2.06260653
77Urethral obstruction (HP:0000796)2.05622376
78Anencephaly (HP:0002323)2.05374629
79Renal cortical cysts (HP:0000803)2.04904979
80Macroorchidism (HP:0000053)2.04326190
81Abnormality of the ileum (HP:0001549)2.03993998
82Prominent nose (HP:0000448)2.03707850
83Progressive inability to walk (HP:0002505)2.02481998
84Lissencephaly (HP:0001339)2.02309837
85Obsessive-compulsive behavior (HP:0000722)2.02158420
86Chromsome breakage (HP:0040012)2.02015356
87Small hand (HP:0200055)2.01833510
88Abnormality of the intervertebral disk (HP:0005108)2.01419071
89Absent speech (HP:0001344)2.00503002
90Abnormality of pyrimidine metabolism (HP:0004353)1.99739673
91Meckel diverticulum (HP:0002245)1.99575966
92Hyperglycinemia (HP:0002154)1.99278269
93Abnormality of monocarboxylic acid metabolism (HP:0010996)1.99050038
94Skull defect (HP:0001362)1.98823146
95Supernumerary bones of the axial skeleton (HP:0009144)1.98587250
96Attenuation of retinal blood vessels (HP:0007843)1.97273107
97Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96541266
98Sandal gap (HP:0001852)1.96096738
99Abnormality of the diencephalon (HP:0010662)1.96013090
100Aplasia/hypoplasia of the uterus (HP:0008684)1.95406776
1013-Methylglutaconic aciduria (HP:0003535)1.95140558
102Methylmalonic aciduria (HP:0012120)1.94745601
103Impulsivity (HP:0100710)1.94588256
104Poor coordination (HP:0002370)1.94523541
105Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92285668
106Intestinal atresia (HP:0011100)1.91849991
107Bile duct proliferation (HP:0001408)1.91263398
108Abnormal biliary tract physiology (HP:0012439)1.91263398
109Aplasia/Hypoplasia of the tongue (HP:0010295)1.90611003
110Cerebral aneurysm (HP:0004944)1.89928505
111Broad thumb (HP:0011304)1.87471247
112Narrow palate (HP:0000189)1.87405824
113Morphological abnormality of the inner ear (HP:0011390)1.87330994
114Fibular aplasia (HP:0002990)1.87272161
115Clumsiness (HP:0002312)1.87045411
116Pelvic girdle muscle weakness (HP:0003749)1.86181303
117Excessive salivation (HP:0003781)1.86130544
118Optic nerve hypoplasia (HP:0000609)1.85710618
119Spina bifida occulta (HP:0003298)1.85558571
120Postaxial foot polydactyly (HP:0001830)1.85048491
121Specific learning disability (HP:0001328)1.84453581
122Chorioretinal atrophy (HP:0000533)1.84392778
123Septo-optic dysplasia (HP:0100842)1.83843235
124Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83629139
125Abnormality of alanine metabolism (HP:0010916)1.83629139
126Hyperalaninemia (HP:0003348)1.83629139
127Bony spicule pigmentary retinopathy (HP:0007737)1.82097741
128Preaxial hand polydactyly (HP:0001177)1.81637933
129Colon cancer (HP:0003003)1.81460180
130Biliary tract neoplasm (HP:0100574)1.81253611
131Acute necrotizing encephalopathy (HP:0006965)1.80173229
132Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.79312444
133Skin tags (HP:0010609)1.79122565
134Selective tooth agenesis (HP:0001592)1.79050144
135Congenital hepatic fibrosis (HP:0002612)1.78955439
136Aplasia/Hypoplasia of the spleen (HP:0010451)1.78815017
137Pachygyria (HP:0001302)1.78625993
138Abnormality of sulfur amino acid metabolism (HP:0004339)1.76994359
139Retinal dysplasia (HP:0007973)1.76991578
140Overriding aorta (HP:0002623)1.76636815
141Abnormality of the labia minora (HP:0012880)1.75988959
142Hypobetalipoproteinemia (HP:0003563)1.75498102
143Abnormality of the proximal phalanges of the hand (HP:0009834)1.75073261
144Adactyly (HP:0009776)1.74929070
145Spastic diplegia (HP:0001264)1.74743027
146Ulnar bowing (HP:0003031)1.73806030
147Oligodactyly (HP:0012165)1.72983340
148Carpal bone hypoplasia (HP:0001498)1.72838214
149Bilateral microphthalmos (HP:0007633)1.72626692
150Absent thumb (HP:0009777)1.72441928
151Protruding tongue (HP:0010808)1.72432655
152Duplicated collecting system (HP:0000081)1.72363766
153Decreased circulating renin level (HP:0003351)1.71898651
154Truncal obesity (HP:0001956)1.71299165
155Cortical dysplasia (HP:0002539)1.71250433
156Abnormal number of incisors (HP:0011064)1.70557325
157Postaxial hand polydactyly (HP:0001162)1.70223882
158Aplasia/Hypoplasia of the sternum (HP:0006714)1.69895253
159Type II lissencephaly (HP:0007260)1.69474387
160Uterine leiomyosarcoma (HP:0002891)1.68903981
161Leiomyosarcoma (HP:0100243)1.68903981
162Intrahepatic cholestasis (HP:0001406)1.68802186
163Shawl scrotum (HP:0000049)1.68543919
164Asplenia (HP:0001746)1.68526559
165Abnormality of chromosome stability (HP:0003220)1.68087583
166Rectal prolapse (HP:0002035)1.66731520
167Back pain (HP:0003418)1.66159364
168Myocardial infarction (HP:0001658)1.65991956
169Increased density of long bones (HP:0006392)1.65881956
170Rib fusion (HP:0000902)1.64177511
171Vertebral arch anomaly (HP:0008438)1.64158691
172Mitral valve prolapse (HP:0001634)1.63495896
173Enlarged penis (HP:0000040)1.62122748
174Large earlobe (HP:0009748)1.61113559
175Low anterior hairline (HP:0000294)1.60711872
176Limited elbow extension (HP:0001377)1.60032835
177Transitional cell carcinoma of the bladder (HP:0006740)1.59099768
178Esophageal varix (HP:0002040)1.58955638
179Smooth philtrum (HP:0000319)1.58747352
180Short phalanx of the thumb (HP:0009660)1.58514409
181Short 5th finger (HP:0009237)1.57387727
182High pitched voice (HP:0001620)1.56929299
183Spinal cord lesions (HP:0100561)1.56855896
184Syringomyelia (HP:0003396)1.56855896
185Epidermoid cyst (HP:0200040)1.54301973
186Deep philtrum (HP:0002002)1.54219391
187Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.53350652
188Short 1st metacarpal (HP:0010034)1.53350652
189Patellar aplasia (HP:0006443)1.52794139
190Overlapping toe (HP:0001845)1.52500000
191Bowel diverticulosis (HP:0005222)1.52189800

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.40305411
2FRK4.28472719
3LATS13.68971174
4WNK33.20611660
5EEF2K2.98166658
6MAP4K22.92129083
7MAP3K102.86642353
8MAP3K42.72870504
9CDC72.64343002
10NEK22.58851158
11PKN22.46010168
12BRD42.43413342
13TRIB32.33790560
14TRIM282.27065455
15NUAK12.25404514
16ZAK2.22540198
17MAP2K72.21784509
18BMPR1B2.21166529
19ADRBK22.17610491
20GRK11.95911933
21SIK11.94256153
22MARK11.93733265
23CAMK1D1.91435514
24PLK41.86394948
25STK31.84840009
26BCR1.82252251
27MTOR1.79589337
28MAPK131.76996614
29PINK11.75237895
30TLK11.74601720
31TTK1.69030988
32CDK41.68970217
33CDK61.68486136
34CASK1.60822314
35LATS21.59149595
36DYRK21.54549482
37INSRR1.53965468
38PTK61.53198257
39ICK1.47377229
40ACVR1B1.46375373
41BCKDK1.45918188
42CAMK1G1.45459913
43PDGFRA1.44049061
44FGFR41.42056867
45ALK1.37871809
46RIPK11.36704445
47CSNK1G31.35448519
48TXK1.31651742
49CSNK1G21.31253506
50CSNK1G11.29157553
51STK38L1.27190326
52STK101.26719132
53PLK21.25989274
54EPHA21.25538103
55RPS6KB21.20404919
56CHEK11.19105349
57VRK11.18793586
58ATR1.17364973
59SIK21.12539518
60CDK71.12372746
61TNIK1.10582320
62WNK41.06110965
63OXSR11.05937946
64TTN1.05267475
65FGFR31.03831292
66TSSK61.00932992
67PRKCG0.99121509
68TIE10.97849854
69PAK30.97413269
70NTRK20.97384262
71CHEK20.96549179
72ATM0.93558084
73CDK90.92828263
74EPHA30.91704809
75CDK20.91608148
76STK40.91236518
77MKNK10.90313221
78TYRO30.89739778
79PIM10.88220158
80MKNK20.86712730
81NME10.86019349
82MAP3K80.85758713
83PLK10.85665265
84PRKCE0.84443224
85SRPK10.84363727
86FGFR10.84321469
87PDGFRB0.83429602
88AURKB0.82547838
89EIF2AK30.82184596
90MELK0.80840105
91PASK0.78080119
92PAK20.77576163
93EPHA40.76972699
94SCYL20.76369024
95BMX0.76066508
96ERBB30.76062451
97CHUK0.74818692
98SGK20.73573960
99RPS6KA50.70536621
100STK390.68737187
101ERBB40.68275407
102PKN10.67987359
103NEK10.67419953
104ERN10.65773159
105BUB10.65351743
106CDK10.65053190
107SGK4940.64970802
108SGK2230.64970802
109FGFR20.64376424
110AKT30.64262140
111SGK30.63581905
112FLT30.63568793
113WEE10.63468209
114ERBB20.63340916
115CSNK1D0.63057024
116CDK190.62848777
117TAOK30.62759565
118BRSK20.62703593
119PAK40.62090563
120RPS6KA40.61561808
121MAP4K10.59666287
122AKT20.59493674
123JAK10.58069505
124VRK20.57731979
125CSNK1A10.57515121
126ADRBK10.57267726
127TGFBR10.56218298
128CSNK1E0.56100179
129PLK30.55801950
130DDR20.55416966
131DYRK1A0.54409645
132MAPK140.52839608
133MAP2K40.52258807
134CAMK40.51936388
135PIK3CA0.51862656
136GRK70.51344876
137DAPK20.49953122
138TAOK10.49294082
139CAMK2A0.48594269
140MAP3K70.48102180
141PRKACA0.47075331
142PDK20.46659398
143AKT10.45891074
144MAPK110.45663870
145MAPK100.45192762
146JAK30.44766496
147NEK90.44553776
148MAPK10.44480801
149GSK3B0.44456419
150CAMKK20.43889522
151PRKDC0.43872071
152CSF1R0.42753234
153PHKG20.42062161
154PHKG10.42062161
155PRKCZ0.41695946
156GRK60.41242868
157CDK30.41143163
158RPS6KA10.41044688
159CSNK1A1L0.40773107
160MARK30.40521177
161DMPK0.39915957
162PAK60.39840273
163PTK20.39539360
164NLK0.39231010
165CAMK10.38614958
166AURKA0.38043464
167STK380.36944860
168DYRK30.36717942
169PRKAA10.36173918
170TEC0.35973583
171JAK20.35613260
172STK110.35184812

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.81634805
2Lysine degradation_Homo sapiens_hsa003102.68667891
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.61594113
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.44186552
5One carbon pool by folate_Homo sapiens_hsa006702.42471320
6RNA polymerase_Homo sapiens_hsa030202.33674341
7Basal transcription factors_Homo sapiens_hsa030222.30253827
8Phototransduction_Homo sapiens_hsa047442.28845784
9Nitrogen metabolism_Homo sapiens_hsa009102.24216708
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.16858888
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.94765385
12Butanoate metabolism_Homo sapiens_hsa006501.92929637
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86194979
14RNA transport_Homo sapiens_hsa030131.81275250
15Protein export_Homo sapiens_hsa030601.79615617
16Selenocompound metabolism_Homo sapiens_hsa004501.78734626
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.75329830
18Taste transduction_Homo sapiens_hsa047421.75304605
19mRNA surveillance pathway_Homo sapiens_hsa030151.69757853
20Cell cycle_Homo sapiens_hsa041101.67307797
21Linoleic acid metabolism_Homo sapiens_hsa005911.66365522
22Arginine biosynthesis_Homo sapiens_hsa002201.64582370
23Morphine addiction_Homo sapiens_hsa050321.62916658
24MicroRNAs in cancer_Homo sapiens_hsa052061.60896439
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60476180
26GABAergic synapse_Homo sapiens_hsa047271.59654149
27Oxidative phosphorylation_Homo sapiens_hsa001901.59388160
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57129146
29Chronic myeloid leukemia_Homo sapiens_hsa052201.56365277
30Notch signaling pathway_Homo sapiens_hsa043301.51425706
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49418724
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49041752
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.47526507
34Parkinsons disease_Homo sapiens_hsa050121.43680360
35mTOR signaling pathway_Homo sapiens_hsa041501.43452327
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42420777
37Spliceosome_Homo sapiens_hsa030401.41274617
38Adherens junction_Homo sapiens_hsa045201.40759382
39Basal cell carcinoma_Homo sapiens_hsa052171.40430714
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36972800
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32263484
42Nucleotide excision repair_Homo sapiens_hsa034201.31902647
43Small cell lung cancer_Homo sapiens_hsa052221.31543960
44Olfactory transduction_Homo sapiens_hsa047401.28741067
45Ether lipid metabolism_Homo sapiens_hsa005651.25777364
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24689474
47Circadian entrainment_Homo sapiens_hsa047131.23682706
48Complement and coagulation cascades_Homo sapiens_hsa046101.20938411
49Endometrial cancer_Homo sapiens_hsa052131.18115945
50Glutamatergic synapse_Homo sapiens_hsa047241.16897817
51Propanoate metabolism_Homo sapiens_hsa006401.16787719
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16364620
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12167666
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.12118777
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10588772
56Retinol metabolism_Homo sapiens_hsa008301.09281551
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09185405
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07137959
59Hippo signaling pathway_Homo sapiens_hsa043901.06603611
60Huntingtons disease_Homo sapiens_hsa050161.06002453
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05522342
62p53 signaling pathway_Homo sapiens_hsa041151.05383798
63Non-small cell lung cancer_Homo sapiens_hsa052231.05084975
64Viral carcinogenesis_Homo sapiens_hsa052031.02781205
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01775366
66Drug metabolism - other enzymes_Homo sapiens_hsa009831.01121240
67Tryptophan metabolism_Homo sapiens_hsa003801.00155397
68Acute myeloid leukemia_Homo sapiens_hsa052211.00070859
69Insulin resistance_Homo sapiens_hsa049310.97853694
70Colorectal cancer_Homo sapiens_hsa052100.96882808
71Serotonergic synapse_Homo sapiens_hsa047260.96806285
72Fanconi anemia pathway_Homo sapiens_hsa034600.95905656
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95404014
74Proteoglycans in cancer_Homo sapiens_hsa052050.94531100
75HTLV-I infection_Homo sapiens_hsa051660.94273165
76Dorso-ventral axis formation_Homo sapiens_hsa043200.93568536
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.92021186
78Peroxisome_Homo sapiens_hsa041460.91047754
79DNA replication_Homo sapiens_hsa030300.90759129
80Biosynthesis of amino acids_Homo sapiens_hsa012300.90684788
81Regulation of autophagy_Homo sapiens_hsa041400.90185699
82Systemic lupus erythematosus_Homo sapiens_hsa053220.89384368
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.88746919
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88652790
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88403603
86Prostate cancer_Homo sapiens_hsa052150.87975863
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87050671
88Purine metabolism_Homo sapiens_hsa002300.85774677
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85588277
90FoxO signaling pathway_Homo sapiens_hsa040680.85221964
91Circadian rhythm_Homo sapiens_hsa047100.84928348
92Pancreatic cancer_Homo sapiens_hsa052120.84084667
93Mismatch repair_Homo sapiens_hsa034300.84037971
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82822076
95TGF-beta signaling pathway_Homo sapiens_hsa043500.82284008
96Herpes simplex infection_Homo sapiens_hsa051680.81256238
97Cardiac muscle contraction_Homo sapiens_hsa042600.80632319
98PPAR signaling pathway_Homo sapiens_hsa033200.79225926
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.79013692
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78868084
101Proteasome_Homo sapiens_hsa030500.78759353
102Dopaminergic synapse_Homo sapiens_hsa047280.77456819
103Viral myocarditis_Homo sapiens_hsa054160.77424796
104Pyrimidine metabolism_Homo sapiens_hsa002400.76825796
105Alzheimers disease_Homo sapiens_hsa050100.75362759
106Hedgehog signaling pathway_Homo sapiens_hsa043400.75133317
107AMPK signaling pathway_Homo sapiens_hsa041520.74908350
108Chemical carcinogenesis_Homo sapiens_hsa052040.74588693
109Insulin secretion_Homo sapiens_hsa049110.74510950
110Bladder cancer_Homo sapiens_hsa052190.74237597
111Vitamin B6 metabolism_Homo sapiens_hsa007500.74049552
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73630339
113Base excision repair_Homo sapiens_hsa034100.72141281
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71913712
115Vitamin digestion and absorption_Homo sapiens_hsa049770.71519772
116Prolactin signaling pathway_Homo sapiens_hsa049170.70501319
117Staphylococcus aureus infection_Homo sapiens_hsa051500.69957308
118Bile secretion_Homo sapiens_hsa049760.69291885
119ABC transporters_Homo sapiens_hsa020100.68729360
120Insulin signaling pathway_Homo sapiens_hsa049100.67062880
121Ovarian steroidogenesis_Homo sapiens_hsa049130.66865422
122RNA degradation_Homo sapiens_hsa030180.66109741
123Fatty acid biosynthesis_Homo sapiens_hsa000610.65539748
124Oocyte meiosis_Homo sapiens_hsa041140.64937871
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.64367261
126Non-homologous end-joining_Homo sapiens_hsa034500.63627547
127Fatty acid degradation_Homo sapiens_hsa000710.63047862
128Calcium signaling pathway_Homo sapiens_hsa040200.63033839
129Cholinergic synapse_Homo sapiens_hsa047250.62876443
130Type II diabetes mellitus_Homo sapiens_hsa049300.62591752
131Caffeine metabolism_Homo sapiens_hsa002320.61704221
132Hepatitis B_Homo sapiens_hsa051610.60511447
133Renal cell carcinoma_Homo sapiens_hsa052110.60095128
134beta-Alanine metabolism_Homo sapiens_hsa004100.59941392
135Pathways in cancer_Homo sapiens_hsa052000.59938908
136Glioma_Homo sapiens_hsa052140.59709798
137Collecting duct acid secretion_Homo sapiens_hsa049660.58820630
138Wnt signaling pathway_Homo sapiens_hsa043100.57646393
139Focal adhesion_Homo sapiens_hsa045100.56167351
140Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55677446
141Steroid biosynthesis_Homo sapiens_hsa001000.54346146
142Apoptosis_Homo sapiens_hsa042100.54124446
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.53774924
144Thyroid cancer_Homo sapiens_hsa052160.53671117
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53150491
146Cocaine addiction_Homo sapiens_hsa050300.51833227
147Fat digestion and absorption_Homo sapiens_hsa049750.51639900
148Epstein-Barr virus infection_Homo sapiens_hsa051690.51596911
149Long-term depression_Homo sapiens_hsa047300.51441558
150Pentose phosphate pathway_Homo sapiens_hsa000300.51148438
151Primary immunodeficiency_Homo sapiens_hsa053400.50457670
152Axon guidance_Homo sapiens_hsa043600.50336832
153Adipocytokine signaling pathway_Homo sapiens_hsa049200.49130907
1542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48355450
155Jak-STAT signaling pathway_Homo sapiens_hsa046300.47290897
156T cell receptor signaling pathway_Homo sapiens_hsa046600.46955295
157Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46818180
158Metabolic pathways_Homo sapiens_hsa011000.45781548
159Alcoholism_Homo sapiens_hsa050340.45369068
160Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45274399
161Intestinal immune network for IgA production_Homo sapiens_hsa046720.44953498
162Toxoplasmosis_Homo sapiens_hsa051450.44775890
163Glucagon signaling pathway_Homo sapiens_hsa049220.43865190
164Cyanoamino acid metabolism_Homo sapiens_hsa004600.43800179
165Homologous recombination_Homo sapiens_hsa034400.43581654

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