RAD9A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.44866469
2translational termination (GO:0006415)7.15820736
3maturation of SSU-rRNA (GO:0030490)6.59256612
4ribosomal small subunit assembly (GO:0000028)6.40584788
5ribosomal small subunit biogenesis (GO:0042274)6.34947762
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.12409038
7translational elongation (GO:0006414)6.10388588
8cotranslational protein targeting to membrane (GO:0006613)6.00543908
9protein targeting to ER (GO:0045047)5.98915536
10ribosomal large subunit biogenesis (GO:0042273)5.85524715
11negative regulation of telomere maintenance (GO:0032205)5.73315326
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.68834401
13cellular protein complex disassembly (GO:0043624)5.61356205
14viral life cycle (GO:0019058)5.60936017
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.59032238
16protein localization to endoplasmic reticulum (GO:0070972)5.58503145
17translational initiation (GO:0006413)5.56674031
18DNA deamination (GO:0045006)5.17120394
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.05498407
20protein complex disassembly (GO:0043241)4.99188541
21macromolecular complex disassembly (GO:0032984)4.74841828
22positive regulation of defense response to virus by host (GO:0002230)4.74091776
23behavioral response to nicotine (GO:0035095)4.47401543
24negative regulation of telomerase activity (GO:0051974)4.43364155
25translation (GO:0006412)4.28723585
26spliceosomal snRNP assembly (GO:0000387)4.16649174
27nuclear-transcribed mRNA catabolic process (GO:0000956)4.14916838
28telomere maintenance via semi-conservative replication (GO:0032201)4.11086168
29DNA strand elongation involved in DNA replication (GO:0006271)4.08798263
30spliceosomal complex assembly (GO:0000245)4.07285737
31ribonucleoprotein complex biogenesis (GO:0022613)4.06236439
32proteasome assembly (GO:0043248)3.99889071
33mRNA catabolic process (GO:0006402)3.95472686
34tolerance induction (GO:0002507)3.91844506
35protein targeting to membrane (GO:0006612)3.88790259
36DNA strand elongation (GO:0022616)3.87896165
37RNA catabolic process (GO:0006401)3.75793962
38rRNA processing (GO:0006364)3.70630474
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.69073181
40ATP synthesis coupled proton transport (GO:0015986)3.69073181
41positive regulation of prostaglandin secretion (GO:0032308)3.67435820
42cellular anion homeostasis (GO:0030002)3.67222502
43regulation of telomere maintenance via telomerase (GO:0032210)3.61368375
44telomere maintenance via recombination (GO:0000722)3.59780422
45fucose catabolic process (GO:0019317)3.57381578
46L-fucose metabolic process (GO:0042354)3.57381578
47L-fucose catabolic process (GO:0042355)3.57381578
48rRNA metabolic process (GO:0016072)3.56523172
49ncRNA 3-end processing (GO:0043628)3.55265436
50cellular response to exogenous dsRNA (GO:0071360)3.50807933
51transcription elongation from RNA polymerase III promoter (GO:0006385)3.48278040
52termination of RNA polymerase III transcription (GO:0006386)3.48278040
53NADH dehydrogenase complex assembly (GO:0010257)3.47791808
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47791808
55mitochondrial respiratory chain complex I assembly (GO:0032981)3.47791808
56DNA replication initiation (GO:0006270)3.45623509
57kinetochore assembly (GO:0051382)3.45095400
58cytidine metabolic process (GO:0046087)3.42478356
59cytidine catabolic process (GO:0006216)3.42478356
60cytidine deamination (GO:0009972)3.42478356
61regulation of defense response to virus by host (GO:0050691)3.41152772
62mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.38646982
63nucleotide-excision repair, DNA gap filling (GO:0006297)3.33839951
64mitotic recombination (GO:0006312)3.31956761
65kinetochore organization (GO:0051383)3.31361103
66formation of translation preinitiation complex (GO:0001731)3.29989758
67telomere maintenance via telomere lengthening (GO:0010833)3.27846098
68antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.26012432
69DNA damage response, detection of DNA damage (GO:0042769)3.25478744
70protein complex biogenesis (GO:0070271)3.25099726
71chromatin remodeling at centromere (GO:0031055)3.20216257
72cellular component biogenesis (GO:0044085)3.19898521
73antigen processing and presentation of endogenous antigen (GO:0019883)3.17741173
74antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.17189385
75negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.16237003
76pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.15213950
77deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.15105309
78cellular response to ATP (GO:0071318)3.13804333
79regulation of telomerase activity (GO:0051972)3.11969592
80pseudouridine synthesis (GO:0001522)3.11928257
81viral mRNA export from host cell nucleus (GO:0046784)3.11706069
82positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.08357992
83axonemal dynein complex assembly (GO:0070286)3.07318162
84mitochondrial respiratory chain complex assembly (GO:0033108)3.06718704
85CENP-A containing nucleosome assembly (GO:0034080)3.06656496
86exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06445375
87transcription-coupled nucleotide-excision repair (GO:0006283)3.02058026
88negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.01132831
89DNA ligation (GO:0006266)2.98680153
90positive regulation of interleukin-17 production (GO:0032740)2.98554310
91negative regulation of T cell differentiation in thymus (GO:0033085)2.98462923
92cellular response to interferon-beta (GO:0035458)2.98427629
93hydrogen peroxide biosynthetic process (GO:0050665)2.97127294
94regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.96483695
95T-helper 1 type immune response (GO:0042088)2.96334999
96regulation of chronic inflammatory response (GO:0002676)2.93867851
97mitotic metaphase plate congression (GO:0007080)2.93675773
98response to interferon-beta (GO:0035456)2.92047029
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91873179
100rRNA modification (GO:0000154)2.91299369
101water-soluble vitamin biosynthetic process (GO:0042364)2.90482759
102DNA unwinding involved in DNA replication (GO:0006268)2.89286933
103epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.89122732
104purinergic nucleotide receptor signaling pathway (GO:0035590)2.88170858
105regulation of regulatory T cell differentiation (GO:0045589)2.86744298
106histone mRNA metabolic process (GO:0008334)2.86400744
107secondary heart field specification (GO:0003139)2.84825538
108heart field specification (GO:0003128)2.84825538
109pyrimidine ribonucleoside catabolic process (GO:0046133)2.83250692
110deoxyribonucleotide catabolic process (GO:0009264)2.82090851
111peptidyl-arginine omega-N-methylation (GO:0035247)2.81571185
112positive regulation of icosanoid secretion (GO:0032305)2.80736908
113positive regulation of cell fate commitment (GO:0010455)2.80705859
114negative regulation of cell killing (GO:0031342)2.80559611
115negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.80559611
116anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80256090
117negative regulation of ligase activity (GO:0051352)2.78883340
118negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.78883340
119positive regulation of T cell mediated cytotoxicity (GO:0001916)2.78007749
120positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.77724537
121regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.77510822
122positive regulation of fatty acid transport (GO:2000193)2.77427648
123sleep (GO:0030431)2.77182271
124RNA splicing, via transesterification reactions (GO:0000375)2.77053238
125negative regulation of T cell mediated immunity (GO:0002710)2.76783317
126mRNA splicing, via spliceosome (GO:0000398)2.75922372
127RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.75922372
128cullin deneddylation (GO:0010388)2.75797909
129CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.75499715
130negative regulation of DNA-templated transcription, elongation (GO:0032785)2.74519844
131mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.74367627
132ncRNA processing (GO:0034470)2.73861878
133negative regulation of RNA splicing (GO:0033119)2.73037047
134regulation of T cell mediated cytotoxicity (GO:0001914)2.72316106
135termination of RNA polymerase II transcription (GO:0006369)2.71870013
136reactive oxygen species biosynthetic process (GO:1903409)2.70855627
137base-excision repair, AP site formation (GO:0006285)2.70433149
138axoneme assembly (GO:0035082)2.70277921
139epithelial cilium movement (GO:0003351)2.68716534
140GTP biosynthetic process (GO:0006183)2.68667411
1417-methylguanosine mRNA capping (GO:0006370)2.68354183
142regulation of prostaglandin secretion (GO:0032306)2.67264354
143RNA capping (GO:0036260)2.64091161
1447-methylguanosine RNA capping (GO:0009452)2.64091161
145regulation of mitochondrial translation (GO:0070129)2.63252387
146DNA-templated transcription, termination (GO:0006353)2.63161834
147establishment of protein localization to membrane (GO:0090150)2.63126923
148interferon-gamma secretion (GO:0072643)2.63054122
149superoxide anion generation (GO:0042554)2.62765308
150necroptotic process (GO:0070266)2.62044189
151regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.62019492
152protein deneddylation (GO:0000338)2.61057742
153* DNA replication checkpoint (GO:0000076)2.60891300
154protein K11-linked ubiquitination (GO:0070979)2.59252748
155DNA replication-independent nucleosome assembly (GO:0006336)2.58993629
156DNA replication-independent nucleosome organization (GO:0034724)2.58993629
157protein-cofactor linkage (GO:0018065)2.58991782
158negative regulation of translational initiation (GO:0045947)2.58241227
159UTP biosynthetic process (GO:0006228)2.58111853
160pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.57828731
161regulation of double-strand break repair via homologous recombination (GO:0010569)2.57549988
162immunoglobulin mediated immune response (GO:0016064)2.56262671
163regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.56064317
164electron transport chain (GO:0022900)2.56040051
165tRNA methylation (GO:0030488)2.55859955
166L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55826253
167cilium movement (GO:0003341)2.55054317
168regulation of alpha-beta T cell proliferation (GO:0046640)2.54627282
169ribosome biogenesis (GO:0042254)2.53692232
170establishment of protein localization to organelle (GO:0072594)2.53609426
171protein targeting (GO:0006605)2.53203223
172negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.52957148
173chaperone-mediated protein transport (GO:0072321)2.52824225
174negative regulation of viral genome replication (GO:0045071)2.52727409
175deoxyribose phosphate catabolic process (GO:0046386)2.52718469
176tRNA modification (GO:0006400)2.51832412
177cytokine biosynthetic process (GO:0042089)2.48503730
178platelet dense granule organization (GO:0060155)2.47382470
179respiratory electron transport chain (GO:0022904)2.45545971
180regulation of mesoderm development (GO:2000380)2.45397276
181negative regulation of DNA biosynthetic process (GO:2000279)2.42806079

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.68201262
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.17943475
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.98260780
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.73724428
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.64599217
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.53645594
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.22422169
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.21323670
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.18582082
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.15031990
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.12062366
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.08401938
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01290502
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94032455
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93783191
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.92374988
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70477189
18XRN2_22483619_ChIP-Seq_HELA_Human2.68203464
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.67428987
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.65301460
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42605358
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.37527722
23VDR_23849224_ChIP-Seq_CD4+_Human2.35005392
24DCP1A_22483619_ChIP-Seq_HELA_Human2.28476148
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24049400
26TTF2_22483619_ChIP-Seq_HELA_Human2.19712589
27BCL6_27268052_Chip-Seq_Bcells_Human2.18811451
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18743664
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.15712418
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13557861
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.12971033
32FOXP3_21729870_ChIP-Seq_TREG_Human2.11180205
33EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.04339702
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.02169072
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.01397025
36* P68_20966046_ChIP-Seq_HELA_Human1.99816799
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97844639
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95513862
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94921425
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.94797481
41* E2F1_20622854_ChIP-Seq_HELA_Human1.94413638
42* BCOR_27268052_Chip-Seq_Bcells_Human1.87702036
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.84097483
44GABP_19822575_ChIP-Seq_HepG2_Human1.83207367
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82065923
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80254387
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79979499
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.79923174
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79331757
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.78675377
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78288841
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77104418
53CIITA_25753668_ChIP-Seq_RAJI_Human1.74586445
54PHF8_20622854_ChIP-Seq_HELA_Human1.73446649
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.72099424
56RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.68882762
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65980091
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65185963
59CTCF_20526341_ChIP-Seq_ESCs_Human1.62644768
60VDR_21846776_ChIP-Seq_THP-1_Human1.61753708
61CTCF_26484167_Chip-Seq_Bcells_Mouse1.60340303
62* P300_27268052_Chip-Seq_Bcells_Human1.60041239
63LXR_22292898_ChIP-Seq_THP-1_Human1.59012945
64KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.58148439
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56575553
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56428398
67* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.55820763
68ELK1_19687146_ChIP-ChIP_HELA_Human1.55673266
69STAT1_20625510_ChIP-Seq_HELA_Human1.55608306
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55501353
71* ERA_21632823_ChIP-Seq_H3396_Human1.54650100
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.54530366
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.53799621
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.53457993
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50480392
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48834887
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47560239
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.47138047
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46488927
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46332868
81MYC_18940864_ChIP-ChIP_HL60_Human1.45917672
82MYC_22102868_ChIP-Seq_BL_Human1.44602412
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44534796
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.40969127
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40959472
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39587826
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.38673682
88RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.38100352
89P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.37707639
90TDRD3_21172665_ChIP-Seq_MCF-7_Human1.35409985
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32982150
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32957860
93* TAF2_19829295_ChIP-Seq_ESCs_Human1.31958945
94* SA1_27219007_Chip-Seq_Bcells_Human1.31185877
95ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29921486
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29029191
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25411114
98P53_21459846_ChIP-Seq_SAOS-2_Human1.25071603
99SPI1_23547873_ChIP-Seq_NB4_Human1.24264970
100ZNF274_21170338_ChIP-Seq_K562_Hela1.22958590
101GATA3_26560356_Chip-Seq_TH2_Human1.22447588
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.22433318
103SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21689352
104RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20623568
105* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20233142
106VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.19958695
107PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19403967
108NANOG_20526341_ChIP-Seq_ESCs_Human1.18920317
109ELK1_22589737_ChIP-Seq_MCF10A_Human1.18143533
110* SA1_27219007_Chip-Seq_ERYTHROID_Human1.17458231
111KDM5A_27292631_Chip-Seq_BREAST_Human1.16206598
112STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15331454
113MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15114118
114RARB_24833708_ChIP-Seq_LIVER_Mouse1.14819555
115GATA3_21878914_ChIP-Seq_MCF-7_Human1.14514889
116POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13955254
117PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13674619
118OCT4_20526341_ChIP-Seq_ESCs_Human1.13348036
119RARA_24833708_ChIP-Seq_LIVER_Mouse1.12645981
120RAC3_21632823_ChIP-Seq_H3396_Human1.12477448
121TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12245350
122SOX2_21211035_ChIP-Seq_LN229_Human1.12160373
123SMC4_20622854_ChIP-Seq_HELA_Human1.10080068
124RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07771331
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07678625
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07514340
127RUNX_20019798_ChIP-Seq_JUKART_Human1.07060012
128PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06945783
129CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06727315
130SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06366563
131MAF_26560356_Chip-Seq_TH2_Human1.04995708
132SPI1_20517297_ChIP-Seq_HL60_Human1.04921215
133BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02303684
134CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01164029
135KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99769252
136IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99393071
137ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98782379
138* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98579439
139UTX_26944678_Chip-Seq_JUKART_Human0.97056365
140KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96995418
141MAF_26560356_Chip-Seq_TH1_Human0.96022970
142ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95222999
143STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92736798
144AR_21909140_ChIP-Seq_LNCAP_Human0.92063973
145OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88124021
146CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88010173
147YY1_22570637_ChIP-Seq_MALME-3M_Human0.87262501
148* TFEB_21752829_ChIP-Seq_HELA_Human0.85210397
149HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84552689
150FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82856107
151CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82221548
152MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.80452602
153FOXP1_21924763_ChIP-Seq_HESCs_Human0.80126059
154RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.79266842
155SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78574528

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.89255572
2MP0009379_abnormal_foot_pigmentation3.82169348
3MP0001873_stomach_inflammation3.72461836
4MP0003111_abnormal_nucleus_morphology3.18992053
5MP0004957_abnormal_blastocyst_morpholog3.17567888
6MP0010094_abnormal_chromosome_stability3.14649999
7MP0003077_abnormal_cell_cycle2.99548721
8MP0008875_abnormal_xenobiotic_pharmacok2.91578753
9MP0008932_abnormal_embryonic_tissue2.81594151
10MP0002138_abnormal_hepatobiliary_system2.65851226
11MP0003806_abnormal_nucleotide_metabolis2.59938842
12MP0008058_abnormal_DNA_repair2.55859078
13MP0008057_abnormal_DNA_replication2.53858366
14MP0010030_abnormal_orbit_morphology2.40461490
15MP0004381_abnormal_hair_follicle2.12099243
16MP0008007_abnormal_cellular_replicative2.11972852
17MP0009333_abnormal_splenocyte_physiolog1.97052926
18MP0003136_yellow_coat_color1.94656375
19MP0003315_abnormal_perineum_morphology1.91618846
20MP0000490_abnormal_crypts_of1.91538437
21MP0006292_abnormal_olfactory_placode1.91167538
22MP0005174_abnormal_tail_pigmentation1.84456346
23MP0001986_abnormal_taste_sensitivity1.82399748
24MP0000049_abnormal_middle_ear1.80686480
25MP0003763_abnormal_thymus_physiology1.80441717
26MP0002102_abnormal_ear_morphology1.78997731
27MP0008872_abnormal_physiological_respon1.78573078
28MP0004133_heterotaxia1.75724634
29MP0002396_abnormal_hematopoietic_system1.74119530
30MP0002653_abnormal_ependyma_morphology1.73050307
31MP0003303_peritoneal_inflammation1.62092998
32MP0002132_abnormal_respiratory_system1.58937158
33MP0001968_abnormal_touch/_nociception1.57003077
34MP0005671_abnormal_response_to1.52310654
35MP0002419_abnormal_innate_immunity1.51974672
36MP0003786_premature_aging1.50566631
37MP0009764_decreased_sensitivity_to1.49523999
38MP0000350_abnormal_cell_proliferation1.48250897
39MP0002234_abnormal_pharynx_morphology1.47452354
40MP0004043_abnormal_pH_regulation1.47357585
41MP0002277_abnormal_respiratory_mucosa1.45243110
42MP0002398_abnormal_bone_marrow1.44464006
43MP0000703_abnormal_thymus_morphology1.43962604
44MP0003195_calcinosis1.39496013
45MP0001800_abnormal_humoral_immune1.36976884
46MP0003011_delayed_dark_adaptation1.35004347
47MP0001845_abnormal_inflammatory_respons1.34456254
48MP0000858_altered_metastatic_potential1.34205547
49MP0002876_abnormal_thyroid_physiology1.33368906
50MP0000313_abnormal_cell_death1.31177455
51MP0005075_abnormal_melanosome_morpholog1.28957142
52MP0003938_abnormal_ear_development1.26852027
53MP0003724_increased_susceptibility_to1.26663844
54MP0001533_abnormal_skeleton_physiology1.25906125
55MP0005000_abnormal_immune_tolerance1.25717112
56MP0000015_abnormal_ear_pigmentation1.25249696
57MP0006082_CNS_inflammation1.24638760
58MP0000685_abnormal_immune_system1.23494312
59MP0002722_abnormal_immune_system1.21600333
60MP0002019_abnormal_tumor_incidence1.20735907
61MP0001835_abnormal_antigen_presentation1.20493008
62MP0008469_abnormal_protein_level1.20353721
63MP0002420_abnormal_adaptive_immunity1.20003474
64MP0005389_reproductive_system_phenotype1.19136803
65MP0001188_hyperpigmentation1.19103101
66MP0001730_embryonic_growth_arrest1.19030919
67MP0002751_abnormal_autonomic_nervous1.18873782
68MP0001819_abnormal_immune_cell1.18719843
69MP0000566_synostosis1.17890578
70MP0005377_hearing/vestibular/ear_phenot1.17869436
71MP0003878_abnormal_ear_physiology1.17869436
72MP0000465_gastrointestinal_hemorrhage1.17344102
73MP0000428_abnormal_craniofacial_morphol1.16481187
74MP0002452_abnormal_antigen_presenting1.16329433
75MP0001697_abnormal_embryo_size1.15569785
76MP0002429_abnormal_blood_cell1.14920166
77MP0000716_abnormal_immune_system1.14071251
78MP0004147_increased_porphyrin_level1.13913815
79MP0003436_decreased_susceptibility_to1.13732281
80MP0009053_abnormal_anal_canal1.13549916
81MP0000689_abnormal_spleen_morphology1.12601462
82MP0003283_abnormal_digestive_organ1.12459243
83MP0009785_altered_susceptibility_to1.11766675
84MP0002723_abnormal_immune_serum1.11511759
85MP0003123_paternal_imprinting1.11370941
86MP0004947_skin_inflammation1.10471801
87MP0002249_abnormal_larynx_morphology1.09859260
88MP0002085_abnormal_embryonic_tissue1.05976770
89MP0005310_abnormal_salivary_gland1.04724356
90MP0002163_abnormal_gland_morphology1.04570235
91MP0005025_abnormal_response_to1.04510680
92MP0002736_abnormal_nociception_after1.04468519
93MP0002148_abnormal_hypersensitivity_rea1.04367351
94MP0001293_anophthalmia1.04064810
95MP0005257_abnormal_intraocular_pressure1.03521970
96MP0003385_abnormal_body_wall1.02921485
97MP0002080_prenatal_lethality1.02871120
98MP0002405_respiratory_system_inflammati1.02131208
99MP0008789_abnormal_olfactory_epithelium1.01043920
100MP0002095_abnormal_skin_pigmentation1.00856996
101MP0002177_abnormal_outer_ear0.99739207
102MP0003718_maternal_effect0.97365627
103MP0008995_early_reproductive_senescence0.96747661
104MP0000613_abnormal_salivary_gland0.96172911
105MP0002933_joint_inflammation0.94796135
106MP0005380_embryogenesis_phenotype0.94761571
107MP0001672_abnormal_embryogenesis/_devel0.94761571
108MP0005409_darkened_coat_color0.94562947
109MP0001765_abnormal_ion_homeostasis0.93952125
110MP0002638_abnormal_pupillary_reflex0.93283559
111MP0005360_urolithiasis0.93094788
112MP0005646_abnormal_pituitary_gland0.92608789
113MP0001919_abnormal_reproductive_system0.91723372
114MP0001286_abnormal_eye_development0.91654379
115MP0004808_abnormal_hematopoietic_stem0.91654305
116MP0003638_abnormal_response/metabolism_0.91078636
117MP0004510_myositis0.87787192
118MP0002160_abnormal_reproductive_system0.87460386
119MP0001764_abnormal_homeostasis0.87251271
120MP0005387_immune_system_phenotype0.86734058
121MP0001790_abnormal_immune_system0.86734058
122MP0002693_abnormal_pancreas_physiology0.86629605
123MP0003866_abnormal_defecation0.84373052
124MP0004742_abnormal_vestibular_system0.84062337
125MP0009250_abnormal_appendicular_skeleto0.83878665
126MP0003119_abnormal_digestive_system0.83735516
127MP0001663_abnormal_digestive_system0.82034840
128MP0005551_abnormal_eye_electrophysiolog0.81267723
129MP0000470_abnormal_stomach_morphology0.79642965
130MP0001905_abnormal_dopamine_level0.78599153
131MP0003984_embryonic_growth_retardation0.78080307
132MP0003448_altered_tumor_morphology0.78035434
133MP0002088_abnormal_embryonic_growth/wei0.78024671
134MP0006036_abnormal_mitochondrial_physio0.77376411
135MP0005448_abnormal_energy_balance0.76207598
136MP0002139_abnormal_hepatobiliary_system0.76206267
137MP0001545_abnormal_hematopoietic_system0.75711372
138MP0005397_hematopoietic_system_phenotyp0.75711372
139MP0003879_abnormal_hair_cell0.75005981
140MP0002210_abnormal_sex_determination0.74818816
141MP0004142_abnormal_muscle_tone0.74444085
142MP0003828_pulmonary_edema0.73898491
143MP0010155_abnormal_intestine_physiology0.73721672
144MP0004885_abnormal_endolymph0.73252172
145MP0005645_abnormal_hypothalamus_physiol0.72893750
146MP0009643_abnormal_urine_homeostasis0.72525762
147MP0008873_increased_physiological_sensi0.72509413
148MP0005381_digestive/alimentary_phenotyp0.71688253
149MP0003646_muscle_fatigue0.71591841
150MP0004019_abnormal_vitamin_homeostasis0.71149465
151MP0002282_abnormal_trachea_morphology0.71042740
152MP0002735_abnormal_chemical_nociception0.69934312
153MP0005083_abnormal_biliary_tract0.68290965
154MP0009765_abnormal_xenobiotic_induced0.68201258
155MP0005636_abnormal_mineral_homeostasis0.67477837

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.85803854
2Abnormality of cells of the erythroid lineage (HP:0012130)4.78325642
3Macrocytic anemia (HP:0001972)4.74894113
4Aplasia/Hypoplasia of the sacrum (HP:0008517)4.72854989
5Abnormal number of erythroid precursors (HP:0012131)4.53047537
6Pallor (HP:0000980)4.45341646
7Abnormal delayed hypersensitivity skin test (HP:0002963)4.04763331
8Concave nail (HP:0001598)3.99034847
9Increased IgM level (HP:0003496)3.69215597
10Abnormal respiratory motile cilium morphology (HP:0005938)3.57847129
11Abnormal respiratory epithelium morphology (HP:0012253)3.57847129
12Absent/shortened dynein arms (HP:0200106)3.52855510
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.52855510
14Autoimmune thrombocytopenia (HP:0001973)3.49581506
15Chronic otitis media (HP:0000389)3.27121947
16Abnormal hemoglobin (HP:0011902)3.24852181
17Increased hepatocellular lipid droplets (HP:0006565)3.12800787
18Breast hypoplasia (HP:0003187)3.12260500
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.06847226
20Triphalangeal thumb (HP:0001199)3.06771584
21Hepatocellular necrosis (HP:0001404)3.03465985
22Molar tooth sign on MRI (HP:0002419)3.02366177
23Abnormality of midbrain morphology (HP:0002418)3.02366177
24Nasal polyposis (HP:0100582)3.01062857
25Chronic sinusitis (HP:0011109)2.97265879
26Abnormal ciliary motility (HP:0012262)2.93798119
27Aplasia/Hypoplasia of the patella (HP:0006498)2.93442982
28Hypochromic anemia (HP:0001931)2.93355614
29Exertional dyspnea (HP:0002875)2.92623622
30Pancreatic cysts (HP:0001737)2.90796507
31Patellar aplasia (HP:0006443)2.83799654
32Mitochondrial inheritance (HP:0001427)2.81185925
33Cerebral hypomyelination (HP:0006808)2.80932476
34Horseshoe kidney (HP:0000085)2.78693299
35Abnormality of T cell physiology (HP:0011840)2.75264697
36Abnormal respiratory motile cilium physiology (HP:0012261)2.73252372
37Meckel diverticulum (HP:0002245)2.71224011
38Stomatitis (HP:0010280)2.69940520
39Clumsiness (HP:0002312)2.65973574
40Congenital stationary night blindness (HP:0007642)2.61285906
41Absent thumb (HP:0009777)2.61201247
42Abnormality of the nasal mucosa (HP:0000433)2.60952427
43Abnormality of the ileum (HP:0001549)2.59413952
44Oral leukoplakia (HP:0002745)2.56230435
45Nephronophthisis (HP:0000090)2.55864404
46Secondary amenorrhea (HP:0000869)2.54500944
47Autoimmune hemolytic anemia (HP:0001890)2.53660678
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.51498761
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.50807668
50Lipid accumulation in hepatocytes (HP:0006561)2.50180964
51Trismus (HP:0000211)2.48619008
52Cleft eyelid (HP:0000625)2.47041012
53Enlarged epiphyses (HP:0010580)2.44993984
54Aplastic anemia (HP:0001915)2.44274180
55Abnormality of the preputium (HP:0100587)2.43603557
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.40071692
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.40071692
58Chromsome breakage (HP:0040012)2.39205372
59Polydipsia (HP:0001959)2.38931495
60Abnormal drinking behavior (HP:0030082)2.38931495
61Abnormal number of incisors (HP:0011064)2.38903791
62Abnormality of T cell number (HP:0011839)2.35166116
63Pancreatic fibrosis (HP:0100732)2.34319980
64Rough bone trabeculation (HP:0100670)2.34097600
65Thrombocytosis (HP:0001894)2.33835912
66Stomach cancer (HP:0012126)2.32334575
67Abnormality of reticulocytes (HP:0004312)2.30653851
68True hermaphroditism (HP:0010459)2.29789845
69Increased CSF lactate (HP:0002490)2.29748512
70Hepatic necrosis (HP:0002605)2.29506190
71Abnormality of T cells (HP:0002843)2.28924137
72Rhinitis (HP:0012384)2.28921435
73Retrobulbar optic neuritis (HP:0100654)2.28372968
74Optic neuritis (HP:0100653)2.28372968
75Hypoplasia of the radius (HP:0002984)2.27175195
76Myositis (HP:0100614)2.26142887
77Increased serum lactate (HP:0002151)2.24348402
78Absent radius (HP:0003974)2.24215385
79Aplasia/hypoplasia of the uterus (HP:0008684)2.23631926
80Renal Fanconi syndrome (HP:0001994)2.21638512
81Chromosomal breakage induced by crosslinking agents (HP:0003221)2.20912214
82Decreased circulating renin level (HP:0003351)2.20538449
83Pustule (HP:0200039)2.20228237
8411 pairs of ribs (HP:0000878)2.17852997
85Birth length less than 3rd percentile (HP:0003561)2.17476134
86Acute necrotizing encephalopathy (HP:0006965)2.17221775
87Congenital, generalized hypertrichosis (HP:0004540)2.17126032
88Pancytopenia (HP:0001876)2.16977027
89Abnormality of eosinophils (HP:0001879)2.15851103
90Type I transferrin isoform profile (HP:0003642)2.15363525
91Seborrheic dermatitis (HP:0001051)2.14894463
92Eosinophilia (HP:0001880)2.14697703
93Elevated erythrocyte sedimentation rate (HP:0003565)2.14408681
94Bronchiectasis (HP:0002110)2.13675505
95Aplasia involving forearm bones (HP:0009822)2.12115023
96Absent forearm bone (HP:0003953)2.12115023
97Depressed nasal ridge (HP:0000457)2.11900695
98Recurrent fungal infections (HP:0002841)2.07873252
99Encephalitis (HP:0002383)2.06356857
100Respiratory difficulties (HP:0002880)2.05476564
101Abnormal lung lobation (HP:0002101)2.05267165
102Premature graying of hair (HP:0002216)2.05181170
103Hypoplasia of the pons (HP:0012110)2.05162991
104Aplasia/Hypoplasia of the uvula (HP:0010293)2.05085964
105Degeneration of anterior horn cells (HP:0002398)2.04802125
106Abnormality of the anterior horn cell (HP:0006802)2.04802125
107Chronic obstructive pulmonary disease (HP:0006510)2.04668627
108Obstructive lung disease (HP:0006536)2.04668627
109Increased intramyocellular lipid droplets (HP:0012240)2.04065057
110Neutropenia (HP:0001875)2.02577078
111Cystic liver disease (HP:0006706)2.00550860
112Abnormal rod and cone electroretinograms (HP:0008323)1.99971207
113Orchitis (HP:0100796)1.98815507
114Atresia of the external auditory canal (HP:0000413)1.98723517
115Colon cancer (HP:0003003)1.98209425
116Abnormality of the pons (HP:0007361)1.98175216
117Granulocytopenia (HP:0001913)1.98103245
118Abnormality of the renal medulla (HP:0100957)1.97104268
119Conical tooth (HP:0000698)1.96818188
120Chronic hepatic failure (HP:0100626)1.96557791
121Tracheoesophageal fistula (HP:0002575)1.96491149
1223-Methylglutaconic aciduria (HP:0003535)1.95054591
123Vasculitis (HP:0002633)1.94755320
124Abnormality of chromosome stability (HP:0003220)1.94655195
125Carpal bone hypoplasia (HP:0001498)1.94560487
126Abnormal mitochondria in muscle tissue (HP:0008316)1.94499883
127Meningitis (HP:0001287)1.93404988
128Pendular nystagmus (HP:0012043)1.92673739
129Sparse lateral eyebrow (HP:0005338)1.90229148
130Thick lower lip vermilion (HP:0000179)1.89767873
131Premature ovarian failure (HP:0008209)1.89376934
132Panhypogammaglobulinemia (HP:0003139)1.87336428
133Polyuria (HP:0000103)1.86785089
134Selective tooth agenesis (HP:0001592)1.86749762
135Down-sloping shoulders (HP:0200021)1.82806693
136Agammaglobulinemia (HP:0004432)1.82789537
137Increased neuronal autofluorescent lipopigment (HP:0002074)1.81844344
138Aplasia/Hypoplasia of the thymus (HP:0010515)1.81592907
139Rhabdomyosarcoma (HP:0002859)1.81451820
140Chronic mucocutaneous candidiasis (HP:0002728)1.81049067
141Recurrent cutaneous fungal infections (HP:0011370)1.81049067
142Bone marrow hypocellularity (HP:0005528)1.80858138
143Attenuation of retinal blood vessels (HP:0007843)1.80509483
144Duplicated collecting system (HP:0000081)1.80320347
145Ridged nail (HP:0001807)1.80238142
146Severe combined immunodeficiency (HP:0004430)1.78946047
147Neoplasm of the pancreas (HP:0002894)1.77934233
148Short femoral neck (HP:0100864)1.77679017
149Chronic bronchitis (HP:0004469)1.77463125
150Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77449565
151Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77170184
152Methylmalonic aciduria (HP:0012120)1.76725424
153Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76552809
154Abnormality of alanine metabolism (HP:0010916)1.76552809
155Hyperalaninemia (HP:0003348)1.76552809
156Bronchitis (HP:0012387)1.76488681
157Microretrognathia (HP:0000308)1.75846767
158Recurrent bronchitis (HP:0002837)1.75818751
159Partial duplication of the phalanx of hand (HP:0009999)1.73842881
160Lymphoma (HP:0002665)1.72659795
161Basal cell carcinoma (HP:0002671)1.71865117
162Microvesicular hepatic steatosis (HP:0001414)1.69948718
163Respiratory failure (HP:0002878)1.69775475
164IgM deficiency (HP:0002850)1.68561837
165Duodenal stenosis (HP:0100867)1.67146962
166Small intestinal stenosis (HP:0012848)1.67146962
167Tetralogy of Fallot (HP:0001636)1.66122195
168Combined immunodeficiency (HP:0005387)1.64749359
169Myelodysplasia (HP:0002863)1.63814931
170Cellular immunodeficiency (HP:0005374)1.63433738
171IgG deficiency (HP:0004315)1.62811183

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.50772258
2EIF2AK14.01905585
3NME23.67116217
4MAP2K63.62253170
5CDK193.47646302
6TESK23.29541463
7SRPK13.26051327
8SIK23.13530988
9STK162.95226415
10MKNK22.85396107
11BLK2.72368067
12ADRBK22.57450703
13WEE12.57266062
14MAP3K102.43657908
15RIPK42.21331179
16PIK3CA2.17722642
17WNK42.16349453
18MKNK12.12240303
19MAP4K22.11992121
20TAOK32.09539244
21MAPK152.08513375
22ZAK2.05941346
23CDC71.89321737
24MAPKAPK31.71904954
25VRK11.66683461
26MAP4K11.64717628
27IRAK41.64060069
28NEK21.59390749
29MAP3K111.57698072
30FRK1.56773616
31OXSR11.56282781
32BCKDK1.49542168
33VRK21.48942895
34IRAK31.46685103
35CLK11.44177586
36CDK71.42573656
37PLK11.41591457
38PIM21.38743639
39DYRK31.37239641
40MAP3K141.36230122
41DAPK31.34333924
42ERN11.33775983
43CASK1.33533414
44GRK11.32095682
45CDK81.29131042
46MAP2K31.24433962
47RPS6KA41.22334420
48GRK71.20012727
49PLK41.16675592
50KDR1.16018122
51TESK11.15213475
52AURKB1.11372797
53MAP3K131.10840218
54AURKA1.10578903
55NME11.10541983
56ILK1.10189259
57NUAK11.07966031
58TNK21.07513571
59PBK1.06273086
60SIK11.03648665
61NEK91.03645580
62TTK1.01793439
63LIMK11.01644633
64BRSK21.01387242
65EIF2AK30.96693932
66STK100.96665811
67ZAP700.95879535
68CHUK0.95622110
69IRAK10.95136017
70TSSK60.94157479
71PHKG20.93259172
72PHKG10.93259172
73BTK0.92468302
74BMPR20.92014476
75BMPR1B0.91939164
76EPHB20.91909704
77ACVR1B0.89118077
78ATR0.88364783
79TXK0.87223492
80ADRBK10.84691792
81CAMKK20.84206184
82IRAK20.82337645
83TEC0.82249932
84TRIB30.79226051
85MATK0.79028275
86LRRK20.78620200
87MAP3K80.77630825
88BRAF0.77525570
89MAP3K50.77507430
90CSF1R0.77464099
91NLK0.75840673
92UHMK10.75725711
93CHEK20.75276885
94MUSK0.71894591
95MAPK120.71246993
96PRKCQ0.68704813
97PAK10.68195316
98TBK10.65887830
99CAMKK10.65816443
100STK40.65614593
101KIT0.65306118
102RPS6KB20.64891383
103JAK30.64427154
104IKBKB0.63972801
105IKBKE0.63782465
106CDK40.63625966
107RPS6KA50.63418604
108BRSK10.62958341
109EIF2AK20.62402177
110PRKCI0.61990024
111PAK40.60844860
112CSNK2A20.60312704
113* CSNK2A10.60081382
114FES0.58704277
115PIM10.58592251
116EPHA20.57568344
117HIPK20.56318257
118LCK0.55824926
119LYN0.55576598
120ITK0.55273431
121PRKD20.54435903
122DYRK20.52243882
123PASK0.50001110
124MST40.49477585
125TAOK20.49216224
126YES10.48924623
127RPS6KA60.47541239
128TYK20.47540810
129INSRR0.47410301
130HCK0.47224276
131PLK30.47094326
132SIK30.46611085
133* CDK20.46001632
134DAPK20.45710348
135GRK60.45064641
136TGFBR10.44547499
137CCNB10.44244309
138CHEK10.43864439
139ABL20.43485315
140MAP2K20.42927358
141CSK0.41508338
142SYK0.41158429
143MAPK110.40912468
144MAPK130.40033641
145CAMK1D0.39459040
146PDPK10.38879280
147* TLK10.38033932
148FLT30.37179735
149STK390.34898809
150MAPKAPK50.33683887
151MARK30.32907862
152PRKCG0.32051779
153TAOK10.31188344
154MAPKAPK20.31149512
155STK110.30821828
156MARK20.30658926
157CDK11A0.30441130
158DYRK1B0.29444237
159* ATM0.28209718

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.02907673
2DNA replication_Homo sapiens_hsa030304.17158699
3Mismatch repair_Homo sapiens_hsa034303.51292226
4Spliceosome_Homo sapiens_hsa030403.26449338
5RNA polymerase_Homo sapiens_hsa030203.25319670
6Homologous recombination_Homo sapiens_hsa034403.13353071
7Proteasome_Homo sapiens_hsa030502.94118635
8Base excision repair_Homo sapiens_hsa034102.91059579
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50558827
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.45667935
11Type I diabetes mellitus_Homo sapiens_hsa049402.43425183
12Nucleotide excision repair_Homo sapiens_hsa034202.37196630
13Pyrimidine metabolism_Homo sapiens_hsa002402.27309880
14RNA transport_Homo sapiens_hsa030132.22709784
15Fanconi anemia pathway_Homo sapiens_hsa034602.20829199
16Linoleic acid metabolism_Homo sapiens_hsa005912.20241618
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.10633536
18One carbon pool by folate_Homo sapiens_hsa006701.95634304
19Cell cycle_Homo sapiens_hsa041101.88365576
20Caffeine metabolism_Homo sapiens_hsa002321.87493606
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72490295
22Basal transcription factors_Homo sapiens_hsa030221.68306277
23Protein export_Homo sapiens_hsa030601.68078146
24Non-homologous end-joining_Homo sapiens_hsa034501.65481657
25Sulfur relay system_Homo sapiens_hsa041221.55992437
26Primary immunodeficiency_Homo sapiens_hsa053401.55073898
27Oxidative phosphorylation_Homo sapiens_hsa001901.52276659
28Parkinsons disease_Homo sapiens_hsa050121.51764556
29African trypanosomiasis_Homo sapiens_hsa051431.49383915
30RNA degradation_Homo sapiens_hsa030181.40672908
31mRNA surveillance pathway_Homo sapiens_hsa030151.39331645
32Rheumatoid arthritis_Homo sapiens_hsa053231.36738128
33Huntingtons disease_Homo sapiens_hsa050161.26026794
34p53 signaling pathway_Homo sapiens_hsa041151.22306768
35Phototransduction_Homo sapiens_hsa047441.21972600
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21535764
37Staphylococcus aureus infection_Homo sapiens_hsa051501.21499256
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12446669
39Purine metabolism_Homo sapiens_hsa002301.07863012
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05151668
41Epstein-Barr virus infection_Homo sapiens_hsa051691.04852360
42Herpes simplex infection_Homo sapiens_hsa051681.04268315
43Systemic lupus erythematosus_Homo sapiens_hsa053221.01922334
44Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96701266
45Nitrogen metabolism_Homo sapiens_hsa009100.94626414
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91193636
47Antigen processing and presentation_Homo sapiens_hsa046120.90542657
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87726142
49Ether lipid metabolism_Homo sapiens_hsa005650.87642248
50Vitamin digestion and absorption_Homo sapiens_hsa049770.86844451
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86314654
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85093726
53Alzheimers disease_Homo sapiens_hsa050100.84606195
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84055537
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81085068
56Toxoplasmosis_Homo sapiens_hsa051450.80922045
57TNF signaling pathway_Homo sapiens_hsa046680.80778562
58Osteoclast differentiation_Homo sapiens_hsa043800.78360752
59Collecting duct acid secretion_Homo sapiens_hsa049660.75748564
60Selenocompound metabolism_Homo sapiens_hsa004500.74123186
61HTLV-I infection_Homo sapiens_hsa051660.72904790
62Tryptophan metabolism_Homo sapiens_hsa003800.72584021
63Basal cell carcinoma_Homo sapiens_hsa052170.71875243
64Measles_Homo sapiens_hsa051620.71215167
65Hematopoietic cell lineage_Homo sapiens_hsa046400.69954149
66Thyroid cancer_Homo sapiens_hsa052160.69584957
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.66060973
68Folate biosynthesis_Homo sapiens_hsa007900.64736448
69Chemical carcinogenesis_Homo sapiens_hsa052040.63583550
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.63284428
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61896095
72Notch signaling pathway_Homo sapiens_hsa043300.61856659
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.61220148
74Tuberculosis_Homo sapiens_hsa051520.59691475
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58485497
76Viral carcinogenesis_Homo sapiens_hsa052030.56676406
77Leishmaniasis_Homo sapiens_hsa051400.56609873
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55234097
79Bladder cancer_Homo sapiens_hsa052190.55012165
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53548931
81Oocyte meiosis_Homo sapiens_hsa041140.51401116
82Pentose phosphate pathway_Homo sapiens_hsa000300.50928966
83Allograft rejection_Homo sapiens_hsa053300.49152462
84Graft-versus-host disease_Homo sapiens_hsa053320.48898906
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48421753
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48311813
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.48258728
88Apoptosis_Homo sapiens_hsa042100.47240114
89Shigellosis_Homo sapiens_hsa051310.47182683
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46824390
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46011249
92Other glycan degradation_Homo sapiens_hsa005110.45038499
93Acute myeloid leukemia_Homo sapiens_hsa052210.44987796
94Lysosome_Homo sapiens_hsa041420.43190511
95Fat digestion and absorption_Homo sapiens_hsa049750.43156907
96T cell receptor signaling pathway_Homo sapiens_hsa046600.43152640
97B cell receptor signaling pathway_Homo sapiens_hsa046620.42397539
98Hepatitis B_Homo sapiens_hsa051610.41355464
99Hedgehog signaling pathway_Homo sapiens_hsa043400.40049236
100Asthma_Homo sapiens_hsa053100.38877573
101MicroRNAs in cancer_Homo sapiens_hsa052060.38679491
102Regulation of autophagy_Homo sapiens_hsa041400.37525217
103Hepatitis C_Homo sapiens_hsa051600.36388896
104Alcoholism_Homo sapiens_hsa050340.35569836
105Arachidonic acid metabolism_Homo sapiens_hsa005900.35493179
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.35182058
107Legionellosis_Homo sapiens_hsa051340.35022892
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33512307
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32548223
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31416870
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30653814
112ABC transporters_Homo sapiens_hsa020100.30165265
113Viral myocarditis_Homo sapiens_hsa054160.29009478
114Influenza A_Homo sapiens_hsa051640.28558357
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28031753
116Metabolic pathways_Homo sapiens_hsa011000.27974977
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27586911
118Chemokine signaling pathway_Homo sapiens_hsa040620.27432092
119Wnt signaling pathway_Homo sapiens_hsa043100.27281030
120Glycerolipid metabolism_Homo sapiens_hsa005610.26954422
121Hippo signaling pathway_Homo sapiens_hsa043900.26908790
122N-Glycan biosynthesis_Homo sapiens_hsa005100.26788285
123Autoimmune thyroid disease_Homo sapiens_hsa053200.26097983
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.25754582
125Sulfur metabolism_Homo sapiens_hsa009200.25631079
126Small cell lung cancer_Homo sapiens_hsa052220.25402646
127Sphingolipid metabolism_Homo sapiens_hsa006000.25238697
128Pathways in cancer_Homo sapiens_hsa052000.24614485
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23436469
130Cardiac muscle contraction_Homo sapiens_hsa042600.22998908
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.22266998
132Pertussis_Homo sapiens_hsa051330.21525544
133Malaria_Homo sapiens_hsa051440.21245580
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21034016
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.20816789
136Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20430898
137Galactose metabolism_Homo sapiens_hsa000520.19987880
138Chronic myeloid leukemia_Homo sapiens_hsa052200.19614331
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.17679951
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17074351
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.16822835
142Leukocyte transendothelial migration_Homo sapiens_hsa046700.16646575

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