RAE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.97634902
2DNA strand elongation involved in DNA replication (GO:0006271)4.81890135
3ribosomal small subunit assembly (GO:0000028)4.75701704
4maturation of SSU-rRNA (GO:0030490)4.68680392
5telomere maintenance via semi-conservative replication (GO:0032201)4.58846289
6DNA strand elongation (GO:0022616)4.56096285
7DNA replication initiation (GO:0006270)4.55724505
8DNA unwinding involved in DNA replication (GO:0006268)4.39016642
9formation of translation preinitiation complex (GO:0001731)4.37169482
10viral transcription (GO:0019083)4.28150194
11translational termination (GO:0006415)4.19551364
12nucleobase biosynthetic process (GO:0046112)4.09814129
13negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.09532290
14telomere maintenance via recombination (GO:0000722)4.03667436
15translational elongation (GO:0006414)3.93768373
16cullin deneddylation (GO:0010388)3.93595016
17ribosome biogenesis (GO:0042254)3.92426476
18folic acid-containing compound biosynthetic process (GO:0009396)3.89053724
19regulation of mitochondrial translation (GO:0070129)3.87275118
20translational initiation (GO:0006413)3.83854877
21ribosomal large subunit biogenesis (GO:0042273)3.83298756
22protein deneddylation (GO:0000338)3.82843017
23ribonucleoprotein complex biogenesis (GO:0022613)3.82775464
24IMP biosynthetic process (GO:0006188)3.78258433
25ribosome assembly (GO:0042255)3.78169698
26ribosomal small subunit biogenesis (GO:0042274)3.77801675
27purine nucleobase biosynthetic process (GO:0009113)3.77266824
28mitotic recombination (GO:0006312)3.77263589
29regulation of cellular amino acid metabolic process (GO:0006521)3.74855437
30DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.73381767
31DNA replication checkpoint (GO:0000076)3.73110824
32DNA replication-dependent nucleosome organization (GO:0034723)3.72587218
33DNA replication-dependent nucleosome assembly (GO:0006335)3.72587218
34signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.70597563
35signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.70597563
36signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.70597563
37intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.70101192
38signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.70101192
39* mitotic nuclear envelope disassembly (GO:0007077)3.69122760
40positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.68756630
41telomere maintenance via telomere lengthening (GO:0010833)3.66346798
42protein localization to kinetochore (GO:0034501)3.65845826
43mitotic metaphase plate congression (GO:0007080)3.65733552
44signal transduction involved in DNA damage checkpoint (GO:0072422)3.63585017
45signal transduction involved in DNA integrity checkpoint (GO:0072401)3.63585017
46SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.62738339
47nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.61519944
48signal transduction involved in cell cycle checkpoint (GO:0072395)3.59098518
49cotranslational protein targeting to membrane (GO:0006613)3.52249202
50pseudouridine synthesis (GO:0001522)3.51818053
51nucleotide-excision repair, DNA gap filling (GO:0006297)3.51810766
52rRNA processing (GO:0006364)3.51496723
53protein targeting to ER (GO:0045047)3.50716218
54spliceosomal snRNP assembly (GO:0000387)3.48848016
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.48084348
56positive regulation of ligase activity (GO:0051351)3.46825187
57chromatin remodeling at centromere (GO:0031055)3.46816478
58CENP-A containing nucleosome assembly (GO:0034080)3.45818498
59proteasome assembly (GO:0043248)3.40844746
60rRNA metabolic process (GO:0016072)3.40080233
61establishment of protein localization to mitochondrial membrane (GO:0090151)3.40023906
62* nuclear envelope disassembly (GO:0051081)3.39970694
63* membrane disassembly (GO:0030397)3.39970694
64regulation of ubiquitin-protein transferase activity (GO:0051438)3.39442507
65IMP metabolic process (GO:0046040)3.35866212
66establishment of protein localization to endoplasmic reticulum (GO:0072599)3.32499542
67protein localization to endoplasmic reticulum (GO:0070972)3.30931509
68cellular protein complex disassembly (GO:0043624)3.30554542
69DNA replication-independent nucleosome organization (GO:0034724)3.30107689
70DNA replication-independent nucleosome assembly (GO:0006336)3.30107689
71protein localization to chromosome, centromeric region (GO:0071459)3.29138958
72viral life cycle (GO:0019058)3.28886469
73metaphase plate congression (GO:0051310)3.28875315
74regulation of ligase activity (GO:0051340)3.22160351
75establishment of viral latency (GO:0019043)3.20616378
76sister chromatid segregation (GO:0000819)3.20156320
77transcription elongation from RNA polymerase III promoter (GO:0006385)3.16897528
78termination of RNA polymerase III transcription (GO:0006386)3.16897528
79spindle checkpoint (GO:0031577)3.14447810
80transcription-coupled nucleotide-excision repair (GO:0006283)3.14390381
81regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.14289014
82tRNA aminoacylation for protein translation (GO:0006418)3.12761584
83negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.11547962
84nuclear pore complex assembly (GO:0051292)3.10815894
85synapsis (GO:0007129)3.09451506
86anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.09085118
87nuclear pore organization (GO:0006999)3.08921615
88viral mRNA export from host cell nucleus (GO:0046784)3.08860991
89establishment of integrated proviral latency (GO:0075713)3.08545888
90kinetochore organization (GO:0051383)3.08099493
91amino acid activation (GO:0043038)3.07307301
92tRNA aminoacylation (GO:0043039)3.07307301
93negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.07224667
94mitotic spindle checkpoint (GO:0071174)3.06967577
95translation (GO:0006412)3.06451054
96regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.05567636
97protein complex disassembly (GO:0043241)3.05408946
98nuclear-transcribed mRNA catabolic process (GO:0000956)3.03664773
99regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.03269432
100negative regulation of RNA splicing (GO:0033119)3.02750246
101base-excision repair, AP site formation (GO:0006285)3.02631237
102rRNA modification (GO:0000154)3.01469073
103chaperone-mediated protein transport (GO:0072321)2.99840425
104maturation of 5.8S rRNA (GO:0000460)2.99277032
105kinetochore assembly (GO:0051382)2.99200945
106protein targeting to mitochondrion (GO:0006626)2.98729339
107pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.97462901
108establishment of chromosome localization (GO:0051303)2.97451736
109positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.96092525
110negative regulation of mitotic sister chromatid separation (GO:2000816)2.95780575
111negative regulation of sister chromatid segregation (GO:0033046)2.95780575
112negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.95780575
113negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.95780575
114negative regulation of mitotic sister chromatid segregation (GO:0033048)2.95780575
115DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.95419411
116attachment of spindle microtubules to kinetochore (GO:0008608)2.95275903
117histone H2A acetylation (GO:0043968)2.95259763
118base-excision repair (GO:0006284)2.94630575
119rRNA methylation (GO:0031167)2.94499160
120histone exchange (GO:0043486)2.92775503
121mitotic sister chromatid segregation (GO:0000070)2.91935580
122somatic hypermutation of immunoglobulin genes (GO:0016446)2.91736875
123somatic diversification of immune receptors via somatic mutation (GO:0002566)2.91736875
124DNA ligation (GO:0006266)2.91582069
125negative regulation of protein ubiquitination (GO:0031397)2.91199534
126DNA duplex unwinding (GO:0032508)2.90855088
127mitotic spindle assembly checkpoint (GO:0007094)2.90766597
128cell cycle G1/S phase transition (GO:0044843)2.90469972
129G1/S transition of mitotic cell cycle (GO:0000082)2.90469972
130macromolecular complex disassembly (GO:0032984)2.90008572
131deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.89198665
132folic acid metabolic process (GO:0046655)2.89105992
133mRNA catabolic process (GO:0006402)2.88633434
134DNA geometric change (GO:0032392)2.88342795
135cellular component biogenesis (GO:0044085)2.88261520
136RNA catabolic process (GO:0006401)2.88132552
137spindle assembly checkpoint (GO:0071173)2.87045013
138mitochondrial RNA metabolic process (GO:0000959)2.85948359
139termination of RNA polymerase II transcription (GO:0006369)2.85597306
140spliceosomal complex assembly (GO:0000245)2.85470778
141RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.85411720
142mRNA splicing, via spliceosome (GO:0000398)2.85411720
143regulation of spindle organization (GO:0090224)2.85316936
144RNA splicing, via transesterification reactions (GO:0000375)2.85308926
145mitotic chromosome condensation (GO:0007076)2.84855790
146negative regulation of chromosome segregation (GO:0051985)2.84051331
147telomere organization (GO:0032200)2.83055490
148telomere maintenance (GO:0000723)2.82897728
149negative regulation of ligase activity (GO:0051352)2.82092178

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.48860428
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.48801826
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.10641775
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.36975016
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27616452
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.04787646
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.97092012
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.93213350
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92704774
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.91606203
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89375428
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.89230636
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.88371730
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.85593992
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.62332740
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47313876
17XRN2_22483619_ChIP-Seq_HELA_Human2.44855354
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.38873030
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37530202
20VDR_23849224_ChIP-Seq_CD4+_Human2.28646394
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.20256478
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18317881
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.05882730
24DCP1A_22483619_ChIP-Seq_HELA_Human2.02401859
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00212871
26FOXP3_21729870_ChIP-Seq_TREG_Human1.99948488
27* GABP_19822575_ChIP-Seq_HepG2_Human1.98633128
28* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93853439
29MYC_22102868_ChIP-Seq_BL_Human1.91909957
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90363578
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89983305
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87692613
33* E2F1_21310950_ChIP-Seq_MCF-7_Human1.84814600
34TTF2_22483619_ChIP-Seq_HELA_Human1.83860414
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83574264
36AR_21909140_ChIP-Seq_LNCAP_Human1.82291033
37CIITA_25753668_ChIP-Seq_RAJI_Human1.81858880
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78242550
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77152070
40* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.73582590
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72294914
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71440988
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.71293448
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.60942730
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59618396
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53551708
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51721863
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46679913
49* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46504068
50KDM5A_27292631_Chip-Seq_BREAST_Human1.45363923
51* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45305864
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45148671
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.42837055
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42753454
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.41784234
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41156663
57ELK1_19687146_ChIP-ChIP_HELA_Human1.40770373
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39984890
59* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37960061
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30878744
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30482028
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30458539
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.29223123
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29007766
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27537326
66VDR_21846776_ChIP-Seq_THP-1_Human1.27302608
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24343529
68SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.23557940
69TFEB_21752829_ChIP-Seq_HELA_Human1.23146819
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19409804
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17672551
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17572703
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14420827
74CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14368354
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.11974247
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11170931
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09312624
78* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05784970
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05619936
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04772869
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04630118
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02714554
83SPI1_23547873_ChIP-Seq_NB4_Human1.01639924
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01441106
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99824857
86CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98948374
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98691930
88SOX17_20123909_ChIP-Seq_XEN_Mouse0.98304626
89PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98042800
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97429078
91SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96952791
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96546385
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96271651
94MYC_18940864_ChIP-ChIP_HL60_Human0.95449902
95* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93746866
96TP63_19390658_ChIP-ChIP_HaCaT_Human0.91999507
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91038752
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90914503
99ELK1_22589737_ChIP-Seq_MCF10A_Human0.88899933
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88658024
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87716947
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87687875
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83962407
104NANOG_21062744_ChIP-ChIP_HESCs_Human0.81452036
105IRF1_19129219_ChIP-ChIP_H3396_Human0.81387171
106NANOG_16153702_ChIP-ChIP_HESCs_Human0.81209196
107CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80743794
108* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79282627
109TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.78482533
110OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77271110
111GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76836273
112ZNF263_19887448_ChIP-Seq_K562_Human0.76830836
113TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76657437
114SOX2_16153702_ChIP-ChIP_HESCs_Human0.72515866
115ELF5_23300383_ChIP-Seq_T47D_Human0.71997434

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.63020235
2MP0010094_abnormal_chromosome_stability4.60375151
3* MP0004957_abnormal_blastocyst_morpholog4.57504787
4* MP0003111_abnormal_nucleus_morphology4.37318943
5* MP0003077_abnormal_cell_cycle4.05249794
6MP0008057_abnormal_DNA_replication3.91463762
7MP0008058_abnormal_DNA_repair3.50050956
8MP0008007_abnormal_cellular_replicative3.06707684
9MP0003123_paternal_imprinting2.73415818
10MP0008932_abnormal_embryonic_tissue2.64314643
11MP0002396_abnormal_hematopoietic_system2.60608209
12MP0001730_embryonic_growth_arrest2.49027337
13MP0008877_abnormal_DNA_methylation2.26247086
14MP0010352_gastrointestinal_tract_polyps2.25472989
15MP0000350_abnormal_cell_proliferation2.24467079
16MP0003786_premature_aging2.21441754
17MP0008789_abnormal_olfactory_epithelium2.21349372
18MP0009697_abnormal_copulation2.17274275
19MP0000490_abnormal_crypts_of2.09578372
20MP0001529_abnormal_vocalization2.09210895
21MP0005499_abnormal_olfactory_system1.92887793
22MP0005394_taste/olfaction_phenotype1.92887793
23MP0000372_irregular_coat_pigmentation1.89788989
24MP0001697_abnormal_embryo_size1.82262610
25MP0004808_abnormal_hematopoietic_stem1.80341910
26MP0002102_abnormal_ear_morphology1.78896882
27MP0003763_abnormal_thymus_physiology1.76354217
28* MP0002080_prenatal_lethality1.71019289
29MP0001672_abnormal_embryogenesis/_devel1.70872092
30MP0005380_embryogenesis_phenotype1.70872092
31MP0010307_abnormal_tumor_latency1.70386791
32MP0001545_abnormal_hematopoietic_system1.67571949
33MP0005397_hematopoietic_system_phenotyp1.67571949
34MP0000313_abnormal_cell_death1.63403896
35* MP0002019_abnormal_tumor_incidence1.61051468
36MP0003984_embryonic_growth_retardation1.54222479
37MP0009333_abnormal_splenocyte_physiolog1.51924345
38* MP0002085_abnormal_embryonic_tissue1.51878803
39MP0002088_abnormal_embryonic_growth/wei1.50281977
40MP0002084_abnormal_developmental_patter1.49004351
41MP0005408_hypopigmentation1.47050474
42MP0003567_abnormal_fetal_cardiomyocyte1.45138104
43MP0006292_abnormal_olfactory_placode1.43654939
44MP0002086_abnormal_extraembryonic_tissu1.40796039
45MP0000703_abnormal_thymus_morphology1.39646168
46MP0003718_maternal_effect1.39427883
47MP0002938_white_spotting1.39355809
48MP0002398_abnormal_bone_marrow1.38174048
49MP0002210_abnormal_sex_determination1.35915407
50MP0008260_abnormal_autophagy1.29696312
51MP0002722_abnormal_immune_system1.28676052
52MP0003806_abnormal_nucleotide_metabolis1.27398582
53MP0000689_abnormal_spleen_morphology1.25342921
54MP0001145_abnormal_male_reproductive1.25152535
55MP0000358_abnormal_cell_content/1.21352059
56MP0004197_abnormal_fetal_growth/weight/1.19082218
57MP0001929_abnormal_gametogenesis1.14615772
58MP0003941_abnormal_skin_development1.13140461
59MP0002233_abnormal_nose_morphology1.08596354
60MP0002429_abnormal_blood_cell1.07019289
61MP0000858_altered_metastatic_potential1.05958207
62MP0003315_abnormal_perineum_morphology1.05295039
63MP0005075_abnormal_melanosome_morpholog1.04943318
64MP0003121_genomic_imprinting1.04935819
65MP0000653_abnormal_sex_gland1.04672008
66MP0001293_anophthalmia1.02717338
67MP0003890_abnormal_embryonic-extraembry0.99699407
68MP0004233_abnormal_muscle_weight0.99695992
69MP0000647_abnormal_sebaceous_gland0.96328783
70MP0003221_abnormal_cardiomyocyte_apopto0.94363769
71MP0006054_spinal_hemorrhage0.94082834
72MP0002161_abnormal_fertility/fecundity0.93678176
73MP0002751_abnormal_autonomic_nervous0.92782736
74MP0003119_abnormal_digestive_system0.92414330
75MP0005384_cellular_phenotype0.92259304
76MP0000716_abnormal_immune_system0.91984150
77MP0001764_abnormal_homeostasis0.91749055
78MP0001853_heart_inflammation0.91223855
79MP0005076_abnormal_cell_differentiation0.88865694
80MP0000685_abnormal_immune_system0.88605605
81MP0004133_heterotaxia0.87904414
82MP0003937_abnormal_limbs/digits/tail_de0.87282121
83MP0000427_abnormal_hair_cycle0.87022587
84MP0005395_other_phenotype0.84803440
85MP0003186_abnormal_redox_activity0.84438378
86MP0009278_abnormal_bone_marrow0.84399300
87MP0008995_early_reproductive_senescence0.84028045
88MP0006036_abnormal_mitochondrial_physio0.83110052
89MP0005621_abnormal_cell_physiology0.83013105
90MP0005501_abnormal_skin_physiology0.80177962
91MP0001119_abnormal_female_reproductive0.80171406
92MP0005671_abnormal_response_to0.79528308
93MP0005410_abnormal_fertilization0.79334905
94MP0002160_abnormal_reproductive_system0.79161882
95MP0005174_abnormal_tail_pigmentation0.78020491
96MP0002736_abnormal_nociception_after0.76838162
97MP0001346_abnormal_lacrimal_gland0.76581804
98MP0002132_abnormal_respiratory_system0.76097323
99MP0010030_abnormal_orbit_morphology0.75336609
100MP0002234_abnormal_pharynx_morphology0.74833233
101MP0002697_abnormal_eye_size0.74242419
102MP0001286_abnormal_eye_development0.74218338
103MP0006035_abnormal_mitochondrial_morpho0.74159085
104MP0009379_abnormal_foot_pigmentation0.73993735
105MP0002653_abnormal_ependyma_morphology0.73596503
106MP0002095_abnormal_skin_pigmentation0.72410787
107MP0000477_abnormal_intestine_morphology0.71437750
108MP0001873_stomach_inflammation0.71353960
109MP0001727_abnormal_embryo_implantation0.70828677
110MP0002420_abnormal_adaptive_immunity0.70330930
111MP0002405_respiratory_system_inflammati0.69974823
112MP0001819_abnormal_immune_cell0.69173785
113MP0003938_abnormal_ear_development0.66854437
114MP0003943_abnormal_hepatobiliary_system0.65285109
115MP0001915_intracranial_hemorrhage0.65266277
116MP0001800_abnormal_humoral_immune0.64357350
117MP0001919_abnormal_reproductive_system0.63971983
118MP0005389_reproductive_system_phenotype0.63860767
119MP0003122_maternal_imprinting0.63433082
120MP0000537_abnormal_urethra_morphology0.62531803
121MP0009672_abnormal_birth_weight0.61439225
122MP0001324_abnormal_eye_pigmentation0.61167874
123MP0000049_abnormal_middle_ear0.60443197
124MP0005266_abnormal_metabolism0.60423403
125MP0005084_abnormal_gallbladder_morpholo0.59981419
126MP0002452_abnormal_antigen_presenting0.59908180
127MP0001835_abnormal_antigen_presentation0.59616446
128MP0008875_abnormal_xenobiotic_pharmacok0.58902859
129MP0005023_abnormal_wound_healing0.57546257
130MP0002090_abnormal_vision0.57295243
131MP0002111_abnormal_tail_morphology0.57200707
132MP0003755_abnormal_palate_morphology0.56643061
133MP0002089_abnormal_postnatal_growth/wei0.56419181
134MP0000465_gastrointestinal_hemorrhage0.56405276
135MP0009703_decreased_birth_body0.56286584
136MP0003698_abnormal_male_reproductive0.56285878
137MP0002075_abnormal_coat/hair_pigmentati0.55834453
138MP0000015_abnormal_ear_pigmentation0.55394266
139MP0002269_muscular_atrophy0.55288393
140MP0003699_abnormal_female_reproductive0.54266207
141MP0003936_abnormal_reproductive_system0.53710554
142MP0002098_abnormal_vibrissa_morphology0.53419824

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.87452443
2Reticulocytopenia (HP:0001896)4.76123734
3Abnormal number of erythroid precursors (HP:0012131)4.75206202
4Birth length less than 3rd percentile (HP:0003561)4.71781039
5Aplastic anemia (HP:0001915)4.06450540
6Microvesicular hepatic steatosis (HP:0001414)3.79273846
7Oral leukoplakia (HP:0002745)3.76091897
8Breast hypoplasia (HP:0003187)3.73691357
9Colon cancer (HP:0003003)3.66385324
10Selective tooth agenesis (HP:0001592)3.62456277
11Abnormal mitochondria in muscle tissue (HP:0008316)3.61573693
12Acute necrotizing encephalopathy (HP:0006965)3.60173379
13Acute encephalopathy (HP:0006846)3.42229413
14Increased CSF lactate (HP:0002490)3.40722216
15Pallor (HP:0000980)3.25772099
16Mitochondrial inheritance (HP:0001427)3.21538817
17Increased hepatocellular lipid droplets (HP:0006565)3.16524450
18Degeneration of anterior horn cells (HP:0002398)3.15214361
19Abnormality of the anterior horn cell (HP:0006802)3.15214361
20Microretrognathia (HP:0000308)3.13891883
21Medulloblastoma (HP:0002885)3.13774384
22Ependymoma (HP:0002888)3.13440769
23Hepatocellular necrosis (HP:0001404)3.12911386
24Macrocytic anemia (HP:0001972)3.12461213
25Abnormal gallbladder physiology (HP:0012438)3.12224749
26Cholecystitis (HP:0001082)3.12224749
27Abnormality of the labia minora (HP:0012880)3.08420279
28Rough bone trabeculation (HP:0100670)3.06514272
29Abnormality of glycolysis (HP:0004366)3.06069916
30Agnosia (HP:0010524)3.03305563
31Thrombocytosis (HP:0001894)3.00957676
32Chromsome breakage (HP:0040012)2.92287811
33Absent thumb (HP:0009777)2.91977667
34Hepatic necrosis (HP:0002605)2.90928033
35Patellar aplasia (HP:0006443)2.90294169
36Cerebral hypomyelination (HP:0006808)2.88944832
37Progressive macrocephaly (HP:0004481)2.87746203
3811 pairs of ribs (HP:0000878)2.85474841
39Carpal bone hypoplasia (HP:0001498)2.84126714
40Myelodysplasia (HP:0002863)2.83091218
41Lipid accumulation in hepatocytes (HP:0006561)2.81015726
42Increased serum pyruvate (HP:0003542)2.77778374
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.74798449
44Abnormality of the preputium (HP:0100587)2.73434985
45Basal cell carcinoma (HP:0002671)2.70710043
46Cerebral edema (HP:0002181)2.69280905
47Type I transferrin isoform profile (HP:0003642)2.68535007
48Aplasia/Hypoplasia of the patella (HP:0006498)2.68421296
49Meckel diverticulum (HP:0002245)2.68014679
50Abnormality of chromosome stability (HP:0003220)2.65065608
51Neoplasm of the pancreas (HP:0002894)2.63982245
52Poikiloderma (HP:0001029)2.60519504
53Abnormality of the ileum (HP:0001549)2.60056696
54Rhabdomyosarcoma (HP:0002859)2.52065463
55Premature graying of hair (HP:0002216)2.50517257
56Premature ovarian failure (HP:0008209)2.49844226
57Bone marrow hypocellularity (HP:0005528)2.49062860
58Renal Fanconi syndrome (HP:0001994)2.45858907
59Lactic acidosis (HP:0003128)2.44965350
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.42311373
61IgM deficiency (HP:0002850)2.42197515
62Increased intramyocellular lipid droplets (HP:0012240)2.38033273
63Abnormality of methionine metabolism (HP:0010901)2.35832280
64Amaurosis fugax (HP:0100576)2.32916639
65Small intestinal stenosis (HP:0012848)2.31392250
66Duodenal stenosis (HP:0100867)2.31392250
67Aplasia/Hypoplasia of the sacrum (HP:0008517)2.31147949
68Trismus (HP:0000211)2.29402782
69Exercise intolerance (HP:0003546)2.28153617
70Abnormality of DNA repair (HP:0003254)2.27185824
71Multiple enchondromatosis (HP:0005701)2.26944217
72Secondary amenorrhea (HP:0000869)2.25418524
73Abnormal number of incisors (HP:0011064)2.22217274
74Cellular immunodeficiency (HP:0005374)2.22195135
75Decreased activity of mitochondrial respiratory chain (HP:0008972)2.21975314
76Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.21975314
77Pancytopenia (HP:0001876)2.19927111
78Volvulus (HP:0002580)2.19513613
79Methylmalonic acidemia (HP:0002912)2.17781366
80Atrophy/Degeneration involving motor neurons (HP:0007373)2.16287298
81Facial cleft (HP:0002006)2.13176088
82Abnormality of the heme biosynthetic pathway (HP:0010472)2.11555263
833-Methylglutaconic aciduria (HP:0003535)2.11490371
84Sloping forehead (HP:0000340)2.11438189
85Absent radius (HP:0003974)2.10439592
86Lymphoma (HP:0002665)2.09991796
87Supernumerary spleens (HP:0009799)2.09649328
88Muscle fiber atrophy (HP:0100295)2.09214849
89Progressive muscle weakness (HP:0003323)2.09204546
90Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07312227
91Squamous cell carcinoma (HP:0002860)2.07161124
92Nephroblastoma (Wilms tumor) (HP:0002667)2.06379329
93Hypoplastic pelvis (HP:0008839)2.06308838
94Abnormal trabecular bone morphology (HP:0100671)2.06081291
95Bifid tongue (HP:0010297)2.05724359
96Horseshoe kidney (HP:0000085)2.04646988
97Tracheoesophageal fistula (HP:0002575)2.03796934
98Abnormal protein glycosylation (HP:0012346)2.00891981
99Abnormal glycosylation (HP:0012345)2.00891981
100Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00891981
101Abnormal protein N-linked glycosylation (HP:0012347)2.00891981
102Entropion (HP:0000621)1.99596575
103Prominent nose (HP:0000448)1.99562603
104Abnormality of alanine metabolism (HP:0010916)1.99406285
105Hyperalaninemia (HP:0003348)1.99406285
106Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99406285
107Abnormality of the duodenum (HP:0002246)1.97869664
108CNS hypomyelination (HP:0003429)1.96424820
109Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.95912354
110Missing ribs (HP:0000921)1.95640542
111Respiratory failure (HP:0002878)1.94832270
112Neoplasm of the colon (HP:0100273)1.94461984
113Methylmalonic aciduria (HP:0012120)1.93937453
114Hypoplasia of the pons (HP:0012110)1.92760546
115Increased serum lactate (HP:0002151)1.92537923
116Personality changes (HP:0000751)1.91883619
117Aplasia involving forearm bones (HP:0009822)1.91145095
118Absent forearm bone (HP:0003953)1.91145095
119Slender long bone (HP:0003100)1.90874883
120Abnormal spermatogenesis (HP:0008669)1.90811761
121Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90731351
122Increased nuchal translucency (HP:0010880)1.90621365
123Tongue fasciculations (HP:0001308)1.89527718
124Type 2 muscle fiber atrophy (HP:0003554)1.88960546
125Embryonal renal neoplasm (HP:0011794)1.88913154
126Abnormality of serum amino acid levels (HP:0003112)1.88762944
127Abnormal lung lobation (HP:0002101)1.88714493
128Abnormality of reticulocytes (HP:0004312)1.87708232
129Microglossia (HP:0000171)1.87577763
130Pulmonary fibrosis (HP:0002206)1.87450851
131Postnatal microcephaly (HP:0005484)1.87362896
132Facial hemangioma (HP:0000329)1.86152734
133Lethargy (HP:0001254)1.85925214
134Neoplasm of the oral cavity (HP:0100649)1.85614623
135Hyperglycinemia (HP:0002154)1.85494202
136Abnormality of the carotid arteries (HP:0005344)1.84656327
137Cleft eyelid (HP:0000625)1.83752591
138Reduced antithrombin III activity (HP:0001976)1.83719265
139Acute lymphatic leukemia (HP:0006721)1.83101414
140Triphalangeal thumb (HP:0001199)1.81408072
141Sparse eyelashes (HP:0000653)1.80651931
142Impulsivity (HP:0100710)1.79797635
143Increased muscle lipid content (HP:0009058)1.79378822
144Choanal atresia (HP:0000453)1.78077497
145Abnormal umbilical cord blood vessels (HP:0011403)1.77826652
146Single umbilical artery (HP:0001195)1.77826652
147Abnormality of the fetal cardiovascular system (HP:0010948)1.77826652
148Posterior subcapsular cataract (HP:0007787)1.75786130
149Poor suck (HP:0002033)1.73764867
150Respiratory difficulties (HP:0002880)1.72493062
151Preaxial hand polydactyly (HP:0001177)1.69593170
152CNS demyelination (HP:0007305)1.69181600
153Shoulder girdle muscle weakness (HP:0003547)1.68957352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.83806740
2WEE14.22340666
3CDC73.64011492
4PBK3.41787708
5EIF2AK13.14621811
6VRK23.10613834
7TRIM282.80784099
8NEK22.55500741
9ACVR1B2.50794044
10STK162.42367847
11NME22.36208360
12SCYL22.26659725
13EIF2AK32.17278665
14TTK2.15373059
15EEF2K2.13757007
16TSSK62.05328405
17MAP3K122.03783629
18RPS6KB22.03622451
19TESK21.99459468
20VRK11.96241537
21NEK11.84026497
22CDK71.83009478
23MST41.79752978
24PLK11.79548508
25DYRK31.77685177
26SRPK11.76716062
27PASK1.76160882
28PDK21.71992864
29RPS6KA41.67109915
30PLK41.66977006
31ATR1.65981777
32MAP4K21.63286907
33TLK11.62795330
34BRSK21.55859060
35NUAK11.54721477
36TGFBR11.50947157
37AURKB1.50684422
38MAP3K81.42219068
39MKNK11.37883603
40FLT31.36967027
41CHEK21.35228759
42CDK41.30723820
43MAPKAPK31.30676372
44PAK41.29249848
45AURKA1.25352399
46BCR1.24665852
47CDK121.24620269
48SIK31.23096006
49PLK31.22900265
50BRSK11.19265194
51PIM21.19173638
52CSNK1G31.18320552
53PKN21.16855452
54EPHA21.15439087
55STK101.11831664
56CHEK11.07162663
57MAP4K11.07095382
58KDR1.05530065
59MAP3K101.03953418
60WNK30.98918204
61CCNB10.96115972
62MAP3K110.95127566
63CSNK1G10.94089047
64CSNK1A1L0.93500798
65MKNK20.92428379
66LIMK10.91715877
67TESK10.90595525
68CDK80.86740061
69PIM10.86223397
70RAF10.83760121
71BRAF0.79254458
72LRRK20.77048516
73CSNK1G20.76928316
74PAK10.74009173
75ATM0.73305879
76CDK20.73222828
77ZAK0.71469331
78BCKDK0.68412986
79MAP2K30.66355917
80CSNK2A20.66205965
81MAP2K70.65346026
82ZAP700.64968440
83PRKCI0.62709243
84TAOK20.61585827
85MET0.61478385
86CSNK2A10.60392331
87BTK0.60011584
88DAPK10.59965733
89ERBB40.59813739
90TAF10.59411669
91MINK10.58363293
92STK40.57950293
93GRK60.56891450
94BMPR1B0.56517265
95RPS6KA50.51748355
96STK38L0.47292050
97IRAK30.47278215
98CDK190.46457551
99MUSK0.45820307
100JAK30.45316927
101CDK10.45181565
102BRD40.44265283
103KSR10.44245096
104KIT0.44071022
105CDK180.43135715
106ALK0.42831874
107PLK20.42787659
108CSNK1E0.42616572
109NME10.41307437
110CDK90.40635239
111MST1R0.40037130
112CDK140.39727118
113ILK0.39222969
114LATS20.38478089
115CDK11A0.37461204
116MAPKAPK50.36413865
117NEK60.36267361
118ERBB30.35246934
119CDK150.34583201
120TEC0.34364034
121STK30.33734771
122CDK60.33160097
123DYRK20.32614931
124MELK0.32423014
125MAP3K60.31838162
126OXSR10.31402395
127AKT20.30435137
128ARAF0.29189301
129PNCK0.29058996
130EIF2AK20.28999118
131MTOR0.28517266
132MAP3K50.27758794
133MATK0.27469697
134MAPK110.24883373
135PDK30.23462433
136PDK40.23462433
137PRKDC0.22777509
138CLK10.22644672
139NLK0.21445061

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.08639037
2Mismatch repair_Homo sapiens_hsa034304.29506963
3Ribosome_Homo sapiens_hsa030103.90953129
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.63529789
5Spliceosome_Homo sapiens_hsa030403.32430131
6Proteasome_Homo sapiens_hsa030503.29830550
7Base excision repair_Homo sapiens_hsa034103.19455112
8RNA polymerase_Homo sapiens_hsa030203.17706506
9* RNA transport_Homo sapiens_hsa030133.03088687
10Homologous recombination_Homo sapiens_hsa034403.02142084
11Nucleotide excision repair_Homo sapiens_hsa034202.99842070
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.60942030
13Cell cycle_Homo sapiens_hsa041102.56130586
14Pyrimidine metabolism_Homo sapiens_hsa002402.52690477
15One carbon pool by folate_Homo sapiens_hsa006702.40481768
16Fanconi anemia pathway_Homo sapiens_hsa034602.14443749
17RNA degradation_Homo sapiens_hsa030182.01544270
18Non-homologous end-joining_Homo sapiens_hsa034501.84931534
19Basal transcription factors_Homo sapiens_hsa030221.83974931
20Fatty acid elongation_Homo sapiens_hsa000621.80711800
21mRNA surveillance pathway_Homo sapiens_hsa030151.60419826
22p53 signaling pathway_Homo sapiens_hsa041151.50820641
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47899183
24Steroid biosynthesis_Homo sapiens_hsa001001.43590761
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41168762
26Purine metabolism_Homo sapiens_hsa002301.33535263
27Pyruvate metabolism_Homo sapiens_hsa006201.24324969
28Propanoate metabolism_Homo sapiens_hsa006401.22394415
29Epstein-Barr virus infection_Homo sapiens_hsa051691.15731325
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13361185
31Pentose phosphate pathway_Homo sapiens_hsa000301.10539771
32Antigen processing and presentation_Homo sapiens_hsa046121.10054613
33Alzheimers disease_Homo sapiens_hsa050101.07520791
34Systemic lupus erythematosus_Homo sapiens_hsa053221.05658204
35Sulfur relay system_Homo sapiens_hsa041221.04644827
36Folate biosynthesis_Homo sapiens_hsa007901.00658319
37Herpes simplex infection_Homo sapiens_hsa051680.99615722
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97660394
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96211377
40Biosynthesis of amino acids_Homo sapiens_hsa012300.93596095
41Oocyte meiosis_Homo sapiens_hsa041140.92714495
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.92137120
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92076810
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92071735
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90971591
46Viral carcinogenesis_Homo sapiens_hsa052030.90046781
47Protein export_Homo sapiens_hsa030600.86962840
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86674588
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78244987
50N-Glycan biosynthesis_Homo sapiens_hsa005100.77426485
51Selenocompound metabolism_Homo sapiens_hsa004500.77057862
52Thyroid cancer_Homo sapiens_hsa052160.76763941
53Vibrio cholerae infection_Homo sapiens_hsa051100.73256545
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.72736141
55HTLV-I infection_Homo sapiens_hsa051660.70352760
56Primary immunodeficiency_Homo sapiens_hsa053400.70260903
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64781014
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64494647
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64021087
60Sulfur metabolism_Homo sapiens_hsa009200.62681959
61Legionellosis_Homo sapiens_hsa051340.60398089
62Shigellosis_Homo sapiens_hsa051310.57696388
63Huntingtons disease_Homo sapiens_hsa050160.57285122
64Peroxisome_Homo sapiens_hsa041460.56978496
65Carbon metabolism_Homo sapiens_hsa012000.55335242
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54741286
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50462879
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50459173
69Regulation of autophagy_Homo sapiens_hsa041400.48192403
70Collecting duct acid secretion_Homo sapiens_hsa049660.47360000
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.45833018
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45508994
73Galactose metabolism_Homo sapiens_hsa000520.45447805
74Fructose and mannose metabolism_Homo sapiens_hsa000510.44318810
75Small cell lung cancer_Homo sapiens_hsa052220.44176052
76Fatty acid metabolism_Homo sapiens_hsa012120.43758198
77Apoptosis_Homo sapiens_hsa042100.43639125
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42060494
79Alcoholism_Homo sapiens_hsa050340.41996049
80Colorectal cancer_Homo sapiens_hsa052100.40920528
81Butanoate metabolism_Homo sapiens_hsa006500.40018179
82Hepatitis B_Homo sapiens_hsa051610.39746214
83Parkinsons disease_Homo sapiens_hsa050120.39196319
84Measles_Homo sapiens_hsa051620.38265893
85Vitamin B6 metabolism_Homo sapiens_hsa007500.36812170
86MicroRNAs in cancer_Homo sapiens_hsa052060.34993929
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.34748892
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33152161
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33122811
90Glutathione metabolism_Homo sapiens_hsa004800.32917164
91Acute myeloid leukemia_Homo sapiens_hsa052210.32785426
92Bladder cancer_Homo sapiens_hsa052190.30629292
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29398817
94Notch signaling pathway_Homo sapiens_hsa043300.26292149
95HIF-1 signaling pathway_Homo sapiens_hsa040660.25482020
96Chronic myeloid leukemia_Homo sapiens_hsa052200.25143568
97Arginine and proline metabolism_Homo sapiens_hsa003300.23908843
98Hematopoietic cell lineage_Homo sapiens_hsa046400.23463729
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23048284
100Renin-angiotensin system_Homo sapiens_hsa046140.20957206
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20695773
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20476539
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20043326
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.19952756
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19790508
106* Influenza A_Homo sapiens_hsa051640.19536686
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19508972
108TGF-beta signaling pathway_Homo sapiens_hsa043500.19288411
109Metabolic pathways_Homo sapiens_hsa011000.17976696
110Cardiac muscle contraction_Homo sapiens_hsa042600.17484186
111Phototransduction_Homo sapiens_hsa047440.17097555
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16633458
113Other glycan degradation_Homo sapiens_hsa005110.14040246
114Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.14014978
115Hippo signaling pathway_Homo sapiens_hsa043900.13810253
116beta-Alanine metabolism_Homo sapiens_hsa004100.13608607
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.13251686
118Viral myocarditis_Homo sapiens_hsa054160.13074355
119Pathways in cancer_Homo sapiens_hsa052000.11825285
120Sphingolipid metabolism_Homo sapiens_hsa006000.11701429
121B cell receptor signaling pathway_Homo sapiens_hsa046620.11269175
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.11098911
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.10948743
124mTOR signaling pathway_Homo sapiens_hsa041500.10173817
125Lysine degradation_Homo sapiens_hsa003100.09625435
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.09609350
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.09178077
128Tyrosine metabolism_Homo sapiens_hsa003500.08928612
129Oxidative phosphorylation_Homo sapiens_hsa001900.08867844
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.08466862
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.07663552
132Caffeine metabolism_Homo sapiens_hsa002320.07374290
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.06679454
134Synaptic vesicle cycle_Homo sapiens_hsa047210.06392232
135Vitamin digestion and absorption_Homo sapiens_hsa049770.03543986
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.00269332
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980-0.0090973

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