RAET1E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.23647467
2phosphatidylinositol acyl-chain remodeling (GO:0036149)5.87354280
3phosphatidylserine acyl-chain remodeling (GO:0036150)5.31163905
4phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.36216286
5folic acid-containing compound biosynthetic process (GO:0009396)4.31135916
6L-fucose catabolic process (GO:0042355)4.28889022
7fucose catabolic process (GO:0019317)4.28889022
8L-fucose metabolic process (GO:0042354)4.28889022
9keratinization (GO:0031424)4.18969116
10serine family amino acid biosynthetic process (GO:0009070)4.09106956
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.99213641
12glycine metabolic process (GO:0006544)3.94855435
13regulation of mitotic spindle organization (GO:0060236)3.82495568
14phosphatidylcholine acyl-chain remodeling (GO:0036151)3.72790175
15detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.71083704
16tetrahydrofolate metabolic process (GO:0046653)3.71038315
17cellular ketone body metabolic process (GO:0046950)3.63986175
18mitotic metaphase plate congression (GO:0007080)3.63027092
19L-serine metabolic process (GO:0006563)3.62365615
20piRNA metabolic process (GO:0034587)3.61067772
21protein localization to kinetochore (GO:0034501)3.57187484
22regulation of spindle organization (GO:0090224)3.56067120
23epithelial cilium movement (GO:0003351)3.53605529
24folic acid metabolic process (GO:0046655)3.52840416
25multicellular organism reproduction (GO:0032504)3.46247568
26platelet dense granule organization (GO:0060155)3.36876744
27indolalkylamine metabolic process (GO:0006586)3.35557610
28primary amino compound metabolic process (GO:1901160)3.34518225
29one-carbon metabolic process (GO:0006730)3.27946282
30aldehyde catabolic process (GO:0046185)3.27820616
31serine family amino acid metabolic process (GO:0009069)3.27209812
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.22323499
33L-phenylalanine metabolic process (GO:0006558)3.22323499
34ketone body metabolic process (GO:1902224)3.21224682
35purine nucleobase biosynthetic process (GO:0009113)3.19008708
36axonemal dynein complex assembly (GO:0070286)3.15843988
37folic acid-containing compound metabolic process (GO:0006760)3.14870636
38negative regulation of fibrinolysis (GO:0051918)3.14600555
39water-soluble vitamin biosynthetic process (GO:0042364)3.12921931
40neuronal action potential (GO:0019228)3.12658550
41nucleobase biosynthetic process (GO:0046112)3.11998564
42negative regulation of T cell differentiation in thymus (GO:0033085)3.11920675
43cysteine metabolic process (GO:0006534)3.11423005
44cilium or flagellum-dependent cell motility (GO:0001539)3.10036005
45mitotic nuclear envelope disassembly (GO:0007077)3.08591895
46ribosome assembly (GO:0042255)3.06252230
47cilium movement (GO:0003341)3.04238194
48formation of translation preinitiation complex (GO:0001731)3.02653990
49axoneme assembly (GO:0035082)3.01940066
50negative regulation of telomere maintenance (GO:0032205)3.00934539
51L-phenylalanine catabolic process (GO:0006559)3.00480687
52erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.00480687
53positive regulation of fatty acid transport (GO:2000193)2.99730940
54chondrocyte proliferation (GO:0035988)2.97725369
55cornea development in camera-type eye (GO:0061303)2.97140355
56phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.97060819
57serotonin metabolic process (GO:0042428)2.97011767
58metaphase plate congression (GO:0051310)2.96813656
59positive regulation of prostaglandin secretion (GO:0032308)2.93338412
60cilium morphogenesis (GO:0060271)2.91069479
61serine family amino acid catabolic process (GO:0009071)2.89442856
62sulfation (GO:0051923)2.89017854
63protein localization to chromosome, centromeric region (GO:0071459)2.88252088
64DNA unwinding involved in DNA replication (GO:0006268)2.87807796
65DNA replication checkpoint (GO:0000076)2.86513157
66membrane disassembly (GO:0030397)2.86138988
67nuclear envelope disassembly (GO:0051081)2.86138988
68protein-cofactor linkage (GO:0018065)2.84380757
69ATP synthesis coupled proton transport (GO:0015986)2.83486955
70energy coupled proton transport, down electrochemical gradient (GO:0015985)2.83486955
71DNA strand elongation involved in DNA replication (GO:0006271)2.83087081
72indole-containing compound metabolic process (GO:0042430)2.81308493
73S-adenosylmethionine metabolic process (GO:0046500)2.80987871
74negative regulation of mast cell activation (GO:0033004)2.80669829
75regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.80280917
76mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.80212459
77reflex (GO:0060004)2.79281005
78homocysteine metabolic process (GO:0050667)2.78765489
79positive regulation of gastrulation (GO:2000543)2.77398589
80pteridine-containing compound biosynthetic process (GO:0042559)2.77200128
81phosphatidylserine metabolic process (GO:0006658)2.77014934
82detection of light stimulus involved in visual perception (GO:0050908)2.76587138
83detection of light stimulus involved in sensory perception (GO:0050962)2.76587138
84DNA replication initiation (GO:0006270)2.75706308
85nucleobase-containing small molecule interconversion (GO:0015949)2.75693404
86sulfur amino acid biosynthetic process (GO:0000097)2.75600034
87photoreceptor cell maintenance (GO:0045494)2.74841023
88sulfur amino acid catabolic process (GO:0000098)2.72928660
89nephron epithelium morphogenesis (GO:0072088)2.72344207
90nephron tubule morphogenesis (GO:0072078)2.72344207
91DNA methylation involved in gamete generation (GO:0043046)2.70811130
92aromatic amino acid family catabolic process (GO:0009074)2.70367276
93mitotic sister chromatid segregation (GO:0000070)2.69205886
94triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.69166907
95proteasome assembly (GO:0043248)2.68930527
96folic acid transport (GO:0015884)2.68671481
97nucleoside salvage (GO:0043174)2.68439942
98heterochromatin organization (GO:0070828)2.66813953
99paraxial mesoderm development (GO:0048339)2.66121667
100behavioral response to ethanol (GO:0048149)2.66097653
101nonmotile primary cilium assembly (GO:0035058)2.65211151
102cilium organization (GO:0044782)2.64954541
103establishment of chromosome localization (GO:0051303)2.64779157
104positive regulation of icosanoid secretion (GO:0032305)2.64735974
105establishment of protein localization to mitochondrial membrane (GO:0090151)2.64542602
106urea cycle (GO:0000050)2.64232994
107urea metabolic process (GO:0019627)2.64232994
108response to pheromone (GO:0019236)2.63193280
109cell adhesion mediated by integrin (GO:0033627)2.63062711
110cAMP catabolic process (GO:0006198)2.63021429
111kidney morphogenesis (GO:0060993)2.62797004
112negative regulation of fatty acid biosynthetic process (GO:0045717)2.62049895
113DNA strand elongation (GO:0022616)2.61759806
114auditory receptor cell stereocilium organization (GO:0060088)2.61656010
115glyoxylate metabolic process (GO:0046487)2.60508786
116regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.60450212
117DNA deamination (GO:0045006)2.58863709
118preassembly of GPI anchor in ER membrane (GO:0016254)2.58710557
119peptidyl-glutamic acid carboxylation (GO:0017187)2.58373076
120protein carboxylation (GO:0018214)2.58373076
121keratinocyte development (GO:0003334)2.56839515
122histone-serine phosphorylation (GO:0035404)2.56660915
123L-methionine salvage (GO:0071267)2.56485137
124L-methionine biosynthetic process (GO:0071265)2.56485137
125amino acid salvage (GO:0043102)2.56485137
126L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.56470299
127sperm motility (GO:0030317)2.56343477
128kynurenine metabolic process (GO:0070189)2.56025293
129rRNA catabolic process (GO:0016075)2.55922065
1303-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.55848594
131purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.55848594
132CENP-A containing nucleosome assembly (GO:0034080)2.55735072
133anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.55197705
134attachment of spindle microtubules to kinetochore (GO:0008608)2.55032264
135cilium assembly (GO:0042384)2.54705318
136regulation of cilium movement (GO:0003352)2.53986241
137pteridine-containing compound metabolic process (GO:0042558)2.53787388
138response to nitrosative stress (GO:0051409)2.52966117
139regulation of fibrinolysis (GO:0051917)2.52058921
140regulation of action potential (GO:0098900)2.52033712
141regulation of centrosome cycle (GO:0046605)2.51802847
142chromatin remodeling at centromere (GO:0031055)2.51275609
143ubiquinone biosynthetic process (GO:0006744)2.51185229
144DNA replication-dependent nucleosome organization (GO:0034723)2.50876420
145DNA replication-dependent nucleosome assembly (GO:0006335)2.50876420
146protein deneddylation (GO:0000338)2.50814214
147regulation of protein activation cascade (GO:2000257)2.50718533
148negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.50066581
149regulation of mesoderm development (GO:2000380)2.49961655
150cullin deneddylation (GO:0010388)2.49609974
151negative regulation of synaptic transmission, GABAergic (GO:0032229)2.49278133
152protein K11-linked deubiquitination (GO:0035871)2.49224289
153regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.48990485
154aspartate family amino acid biosynthetic process (GO:0009067)2.47808879
155keratinocyte proliferation (GO:0043616)2.47439987
156positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.47306642
157kinetochore organization (GO:0051383)2.46387047
158bile acid biosynthetic process (GO:0006699)2.46313506
159nuclear pore organization (GO:0006999)2.45993418
160somite development (GO:0061053)2.45861542
161positive regulation of meiotic cell cycle (GO:0051446)2.45786042
162telomere maintenance via semi-conservative replication (GO:0032201)2.45567756
163regulation of rhodopsin mediated signaling pathway (GO:0022400)2.44746408
164sister chromatid segregation (GO:0000819)2.44730920
165pseudouridine synthesis (GO:0001522)2.44520734
166hair cycle (GO:0042633)2.43067613
167molting cycle (GO:0042303)2.43067613
168mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.42790231
169alpha-amino acid biosynthetic process (GO:1901607)2.42414399
170tryptophan catabolic process (GO:0006569)2.41928391
171indole-containing compound catabolic process (GO:0042436)2.41928391
172indolalkylamine catabolic process (GO:0046218)2.41928391
173regulation of mitotic metaphase/anaphase transition (GO:0030071)2.41485788
174amine catabolic process (GO:0009310)2.40986226
175cellular biogenic amine catabolic process (GO:0042402)2.40986226
176organ regeneration (GO:0031100)2.40979821
177photoreceptor cell development (GO:0042461)2.40538815
178protein complex biogenesis (GO:0070271)2.40378983
179epoxygenase P450 pathway (GO:0019373)2.39739401
180protein K6-linked ubiquitination (GO:0085020)2.39591380
181spindle checkpoint (GO:0031577)2.39393199
182ubiquinone metabolic process (GO:0006743)2.39228478
183ribosomal large subunit biogenesis (GO:0042273)2.38971128
184tryptophan metabolic process (GO:0006568)2.38761371
185cyclic nucleotide catabolic process (GO:0009214)2.38599042
186rhodopsin mediated signaling pathway (GO:0016056)2.38317667
187nitrogen cycle metabolic process (GO:0071941)2.37749342
188positive regulation of SMAD protein import into nucleus (GO:0060391)2.37709212
189telomere maintenance via recombination (GO:0000722)2.37532084
190regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.37480621

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.22375597
2ZNF274_21170338_ChIP-Seq_K562_Hela3.99206208
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.90167908
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.66583886
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.60200002
6VDR_22108803_ChIP-Seq_LS180_Human3.40257041
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.07426350
8GBX2_23144817_ChIP-Seq_PC3_Human2.90838619
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.83831121
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78036432
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66651369
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61355596
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56131798
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51340701
15AR_21909140_ChIP-Seq_LNCAP_Human2.50983762
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49966376
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.46252799
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33843091
19RXR_22158963_ChIP-Seq_LIVER_Mouse2.33178302
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.32728554
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.31631711
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28017392
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.27154484
24EZH2_22144423_ChIP-Seq_EOC_Human2.25290217
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.24399164
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.24304198
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24082910
28PPARA_22158963_ChIP-Seq_LIVER_Mouse2.22624652
29CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.17411113
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.15179478
31EST1_17652178_ChIP-ChIP_JURKAT_Human2.14213386
32EGR1_23403033_ChIP-Seq_LIVER_Mouse2.07893863
33IGF1R_20145208_ChIP-Seq_DFB_Human2.06615491
34GABP_17652178_ChIP-ChIP_JURKAT_Human2.04044475
35POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03231553
36E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02683186
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.01865045
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.99840675
39FUS_26573619_Chip-Seq_HEK293_Human1.99325658
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91166016
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.90173489
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.88033303
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.87899860
44EWS_26573619_Chip-Seq_HEK293_Human1.87145341
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.86972833
46ER_23166858_ChIP-Seq_MCF-7_Human1.86551122
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.85988618
48TAF15_26573619_Chip-Seq_HEK293_Human1.83792420
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.83462281
50XRN2_22483619_ChIP-Seq_HELA_Human1.82358557
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81902699
52P300_19829295_ChIP-Seq_ESCs_Human1.81842175
53DCP1A_22483619_ChIP-Seq_HELA_Human1.79862276
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.76407722
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74437308
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72671407
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69792149
58AR_25329375_ChIP-Seq_VCAP_Human1.65405724
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64931389
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.62428487
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.59336665
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.59336665
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57644931
64LXR_22158963_ChIP-Seq_LIVER_Mouse1.57485857
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.56145414
66TP53_22573176_ChIP-Seq_HFKS_Human1.56123454
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.55799174
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52919336
69BCAT_22108803_ChIP-Seq_LS180_Human1.52289562
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51610030
71CLOCK_20551151_ChIP-Seq_293T_Human1.51038563
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50906606
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50053425
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48165418
75ELK1_19687146_ChIP-ChIP_HELA_Human1.47679417
76MYC_18940864_ChIP-ChIP_HL60_Human1.47597254
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.46484514
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.45942201
79* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42972802
80STAT3_23295773_ChIP-Seq_U87_Human1.42550188
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41443261
82SMAD4_21799915_ChIP-Seq_A2780_Human1.40986432
83* GATA3_21878914_ChIP-Seq_MCF-7_Human1.40143198
84TCF3_18692474_ChIP-Seq_MEFs_Mouse1.39843760
85CBP_20019798_ChIP-Seq_JUKART_Human1.39475164
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39475164
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38783673
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.38699507
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.38084748
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37611800
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36683679
92AR_20517297_ChIP-Seq_VCAP_Human1.36366723
93TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36270922
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34455320
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33581785
96TTF2_22483619_ChIP-Seq_HELA_Human1.33380574
97REST_21632747_ChIP-Seq_MESCs_Mouse1.33273084
98TCF4_22108803_ChIP-Seq_LS180_Human1.32811195
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32620504
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32537666
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32537666
102KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32537666
103GABP_19822575_ChIP-Seq_HepG2_Human1.32135647
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31826137
105VDR_23849224_ChIP-Seq_CD4+_Human1.30395638
106HOXB7_26014856_ChIP-Seq_BT474_Human1.30135534
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29799625
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29503412
109NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29109063
110KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28246212
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28036257
112TCF4_23295773_ChIP-Seq_U87_Human1.27991002
113SOX2_19829295_ChIP-Seq_ESCs_Human1.27558130
114NANOG_19829295_ChIP-Seq_ESCs_Human1.27558130
115TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26988384
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26785590
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26785590
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26403524
119TFEB_21752829_ChIP-Seq_HELA_Human1.26066582
120SMAD3_21741376_ChIP-Seq_EPCs_Human1.25552944
121SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25284317
122PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23913214
123NCOR_22424771_ChIP-Seq_293T_Human1.23592623
124AR_21572438_ChIP-Seq_LNCaP_Human1.22675796
125CBX2_27304074_Chip-Seq_ESCs_Mouse1.22376835
126KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21901164
127FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21755089
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21670889
129TAF2_19829295_ChIP-Seq_ESCs_Human1.21403103
130NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20997892
131SMAD4_21741376_ChIP-Seq_EPCs_Human1.20749090
132ETV2_25802403_ChIP-Seq_MESCs_Mouse1.20189562
133ERA_21632823_ChIP-Seq_H3396_Human1.19881138
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18547208
135KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18432129
136KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17389064
137AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14623972
138SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14431614
139POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14353998
140SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12942228
141RUNX2_22187159_ChIP-Seq_PCA_Human1.12918687
142SOX2_18692474_ChIP-Seq_MEFs_Mouse1.12388285
143FOXP3_21729870_ChIP-Seq_TREG_Human1.11942501
144FOXH1_21741376_ChIP-Seq_EPCs_Human1.11880105
145MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10207446
146SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10061601
147HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09824560
148RNF2_27304074_Chip-Seq_NSC_Mouse1.09816280
149MYC_19829295_ChIP-Seq_ESCs_Human1.09620439
150* CDX2_22108803_ChIP-Seq_LS180_Human1.09403385
151NANOG_20526341_ChIP-Seq_ESCs_Human1.09258337
152SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08763628
153KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08322648
154ELK1_22589737_ChIP-Seq_MCF10A_Human1.07339884
155ATF3_27146783_Chip-Seq_COLON_Human1.06695554
156SRF_21415370_ChIP-Seq_HL-1_Mouse1.04065158
157EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04008764
158CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03931946
159OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03866554
160EED_16625203_ChIP-ChIP_MESCs_Mouse1.03064456
161TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03058841
162SOX17_20123909_ChIP-Seq_XEN_Mouse1.02399085
163ERG_20517297_ChIP-Seq_VCAP_Human1.02038323
164CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01999381
165KDM5A_27292631_Chip-Seq_BREAST_Human1.01540885
166ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01321061
167HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00925095
168PRDM14_20953172_ChIP-Seq_ESCs_Human1.00867719
169P53_21459846_ChIP-Seq_SAOS-2_Human1.00592685
170EZH2_27294783_Chip-Seq_NPCs_Mouse1.00527645
171NANOG_18555785_Chip-Seq_ESCs_Mouse0.99490366
172CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99354657
173NFE2_27457419_Chip-Seq_LIVER_Mouse0.99352467
174TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99275300
175RXR_22108803_ChIP-Seq_LS180_Human0.98432907
176NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97972657
177PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97902916
178TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97648726
179SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97502894
180PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97226718
181HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.97143318
182SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97024624
183SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96871857
184* FLI1_21867929_ChIP-Seq_TH2_Mouse0.96602874
185CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95736667
186SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95718478
187SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95585596
188ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95485926
189EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94824793
190RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94820053
191FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93502971
192PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92758279
193SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91653721
194PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90749192
195ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90468059

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.66265282
2MP0003806_abnormal_nucleotide_metabolis3.66250094
3MP0003705_abnormal_hypodermis_morpholog3.45598668
4MP0005360_urolithiasis3.25529208
5MP0001968_abnormal_touch/_nociception3.01200547
6MP0008438_abnormal_cutaneous_collagen3.00502406
7MP0003693_abnormal_embryo_hatching2.75899216
8MP0000569_abnormal_digit_pigmentation2.75782785
9MP0005085_abnormal_gallbladder_physiolo2.63532883
10MP0005551_abnormal_eye_electrophysiolog2.58182895
11MP0002837_dystrophic_cardiac_calcinosis2.53045966
12MP0004885_abnormal_endolymph2.50809876
13MP0002102_abnormal_ear_morphology2.49705145
14MP0000427_abnormal_hair_cycle2.42014120
15MP0004957_abnormal_blastocyst_morpholog2.38615358
16MP0005365_abnormal_bile_salt2.36348007
17MP0008877_abnormal_DNA_methylation2.29297881
18MP0002653_abnormal_ependyma_morphology2.29155750
19MP0000579_abnormal_nail_morphology2.17635106
20MP0003111_abnormal_nucleus_morphology2.14421166
21MP0009840_abnormal_foam_cell2.14097856
22MP0002938_white_spotting2.11280293
23MP0010030_abnormal_orbit_morphology2.02105078
24MP0005275_abnormal_skin_tensile1.97085022
25MP0002736_abnormal_nociception_after1.95149581
26MP0005023_abnormal_wound_healing1.94440132
27MP0009053_abnormal_anal_canal1.88783566
28MP0010352_gastrointestinal_tract_polyps1.87775261
29MP0010094_abnormal_chromosome_stability1.87665565
30MP0008932_abnormal_embryonic_tissue1.87132425
31MP0005503_abnormal_tendon_morphology1.86412381
32MP0003077_abnormal_cell_cycle1.86047250
33MP0002876_abnormal_thyroid_physiology1.84562091
34MP0001501_abnormal_sleep_pattern1.83817456
35MP0003136_yellow_coat_color1.83600962
36MP0009745_abnormal_behavioral_response1.81745542
37MP0003646_muscle_fatigue1.80049490
38MP0003718_maternal_effect1.79235891
39MP0004043_abnormal_pH_regulation1.78594069
40MP0005083_abnormal_biliary_tract1.77332412
41MP0008875_abnormal_xenobiotic_pharmacok1.76626569
42MP0003186_abnormal_redox_activity1.74732628
43MP0004133_heterotaxia1.74414252
44MP0009046_muscle_twitch1.72046160
45MP0010368_abnormal_lymphatic_system1.71819643
46MP0005646_abnormal_pituitary_gland1.71380236
47MP0004147_increased_porphyrin_level1.70894579
48MP0000372_irregular_coat_pigmentation1.70152783
49MP0001485_abnormal_pinna_reflex1.69332423
50MP0006072_abnormal_retinal_apoptosis1.65624809
51MP0000383_abnormal_hair_follicle1.59408254
52MP0002638_abnormal_pupillary_reflex1.58948971
53MP0009697_abnormal_copulation1.57590027
54MP0003252_abnormal_bile_duct1.55692532
55MP0000566_synostosis1.55261555
56MP0003566_abnormal_cell_adhesion1.53799804
57MP0005253_abnormal_eye_physiology1.52377662
58MP0010386_abnormal_urinary_bladder1.52020499
59MP0005084_abnormal_gallbladder_morpholo1.51213844
60MP0000647_abnormal_sebaceous_gland1.50875104
61MP0008872_abnormal_physiological_respon1.50795521
62MP0001730_embryonic_growth_arrest1.50658733
63MP0004142_abnormal_muscle_tone1.50376647
64MP0008007_abnormal_cellular_replicative1.48893062
65MP0005410_abnormal_fertilization1.48196086
66MP0001986_abnormal_taste_sensitivity1.45038070
67MP0002277_abnormal_respiratory_mucosa1.44926952
68MP0002272_abnormal_nervous_system1.44134279
69MP0002095_abnormal_skin_pigmentation1.43735478
70MP0002234_abnormal_pharynx_morphology1.42986646
71MP0005174_abnormal_tail_pigmentation1.40364615
72MP0005645_abnormal_hypothalamus_physiol1.39601871
73MP0001905_abnormal_dopamine_level1.39051596
74MP0000631_abnormal_neuroendocrine_gland1.37655493
75MP0010307_abnormal_tumor_latency1.36942149
76MP0002160_abnormal_reproductive_system1.31849239
77MP0003941_abnormal_skin_development1.30155486
78MP0009384_cardiac_valve_regurgitation1.28757880
79MP0000350_abnormal_cell_proliferation1.28183764
80MP0002572_abnormal_emotion/affect_behav1.27987723
81MP0005332_abnormal_amino_acid1.26688779
82MP0004145_abnormal_muscle_electrophysio1.25021314
83MP0005451_abnormal_body_composition1.24766262
84MP0001486_abnormal_startle_reflex1.24146525
85MP0003880_abnormal_central_pattern1.23849881
86MP0003279_aneurysm1.23810141
87MP0008775_abnormal_heart_ventricle1.22453890
88MP0002796_impaired_skin_barrier1.19994863
89MP0001542_abnormal_bone_strength1.17918914
90MP0010329_abnormal_lipoprotein_level1.17125946
91MP0002733_abnormal_thermal_nociception1.15977589
92MP0004742_abnormal_vestibular_system1.15943511
93MP0005257_abnormal_intraocular_pressure1.15730156
94MP0003123_paternal_imprinting1.15674362
95MP0000230_abnormal_systemic_arterial1.15501830
96MP0001243_abnormal_dermal_layer1.15365943
97MP0005389_reproductive_system_phenotype1.15143568
98MP0002557_abnormal_social/conspecific_i1.14422819
99MP0010678_abnormal_skin_adnexa1.14126279
100MP0005380_embryogenesis_phenotype1.13156512
101MP0001672_abnormal_embryogenesis/_devel1.13156512
102MP0003638_abnormal_response/metabolism_1.12884924
103MP0006292_abnormal_olfactory_placode1.11085414
104MP0002909_abnormal_adrenal_gland1.10693713
105MP0001984_abnormal_olfaction1.09924449
106MP0002088_abnormal_embryonic_growth/wei1.09165685
107MP0001666_abnormal_nutrient_absorption1.08898272
108MP0003984_embryonic_growth_retardation1.07881637
109MP0004272_abnormal_basement_membrane1.06543889
110MP0005377_hearing/vestibular/ear_phenot1.05344601
111MP0003878_abnormal_ear_physiology1.05344601
112MP0001915_intracranial_hemorrhage1.04640444
113MP0005395_other_phenotype1.04186692
114MP0001697_abnormal_embryo_size1.04079273
115MP0003195_calcinosis1.04010938
116MP0002928_abnormal_bile_duct1.04004922
117MP0000598_abnormal_liver_morphology1.03734415
118MP0006276_abnormal_autonomic_nervous1.03534388
119MP0002064_seizures1.03213897
120MP0000609_abnormal_liver_physiology0.99685750
121MP0005508_abnormal_skeleton_morphology0.98905114
122MP0002735_abnormal_chemical_nociception0.98429618
123MP0004197_abnormal_fetal_growth/weight/0.98337004
124MP0001502_abnormal_circadian_rhythm0.98314615
125MP0005075_abnormal_melanosome_morpholog0.97669339
126MP0005408_hypopigmentation0.97542485
127MP0005367_renal/urinary_system_phenotyp0.97338364
128MP0000516_abnormal_urinary_system0.97338364
129MP0002282_abnormal_trachea_morphology0.96584390
130MP0001188_hyperpigmentation0.96307406
131MP0003698_abnormal_male_reproductive0.95578886
132MP0001970_abnormal_pain_threshold0.95159607
133MP0003091_abnormal_cell_migration0.94799539
134MP0009780_abnormal_chondrocyte_physiolo0.94638870
135MP0002086_abnormal_extraembryonic_tissu0.94596581
136MP0005171_absent_coat_pigmentation0.94101048
137MP0000026_abnormal_inner_ear0.92436236
138MP0005195_abnormal_posterior_eye0.91297935
139MP0002080_prenatal_lethality0.91204601
140MP0000538_abnormal_urinary_bladder0.90488048
141MP0002138_abnormal_hepatobiliary_system0.90318412
142MP0002734_abnormal_mechanical_nocicepti0.90178043
143MP0005076_abnormal_cell_differentiation0.89879869
144MP0005319_abnormal_enzyme/_coenzyme0.89226890
145MP0002254_reproductive_system_inflammat0.89093423
146MP0002060_abnormal_skin_morphology0.88775139
147MP0000537_abnormal_urethra_morphology0.88202401
148MP0002067_abnormal_sensory_capabilities0.88108740
149MP0002085_abnormal_embryonic_tissue0.88088470
150MP0004924_abnormal_behavior0.87313140
151MP0005386_behavior/neurological_phenoty0.87313140
152MP0005248_abnormal_Harderian_gland0.87123596
153MP0004019_abnormal_vitamin_homeostasis0.86612365
154MP0006054_spinal_hemorrhage0.84245600
155MP0002877_abnormal_melanocyte_morpholog0.84076914
156MP0001929_abnormal_gametogenesis0.83664801
157MP0000470_abnormal_stomach_morphology0.83032203
158MP0001440_abnormal_grooming_behavior0.81544458
159MP0005423_abnormal_somatic_nervous0.81248135
160MP0002111_abnormal_tail_morphology0.81058239
161MP0003011_delayed_dark_adaptation0.81033388
162MP0001529_abnormal_vocalization0.78991442
163MP0003453_abnormal_keratinocyte_physiol0.78691367
164MP0000467_abnormal_esophagus_morphology0.78569770
165MP0000858_altered_metastatic_potential0.78333735
166MP0003567_abnormal_fetal_cardiomyocyte0.78157906
167MP0010771_integument_phenotype0.77729160
168MP0002084_abnormal_developmental_patter0.75362390
169MP0000750_abnormal_muscle_regeneration0.74695233
170MP0008058_abnormal_DNA_repair0.74110276
171MP0000733_abnormal_muscle_development0.73406684
172MP0005058_abnormal_lysosome_morphology0.72918749
173MP0003942_abnormal_urinary_system0.71576494
174MP0003436_decreased_susceptibility_to0.70698509
175MP0003786_premature_aging0.70293660
176MP0003890_abnormal_embryonic-extraembry0.69303508
177MP0000358_abnormal_cell_content/0.68720186
178MP0005390_skeleton_phenotype0.68511079
179MP0003950_abnormal_plasma_membrane0.68469838
180MP0009379_abnormal_foot_pigmentation0.68072673
181MP0002019_abnormal_tumor_incidence0.66370050
182MP0003283_abnormal_digestive_organ0.65350782
183MP0003937_abnormal_limbs/digits/tail_de0.64392050
184MP0000627_abnormal_mammary_gland0.63960679
185MP0001119_abnormal_female_reproductive0.63959128
186MP0009672_abnormal_birth_weight0.63771859
187MP0000767_abnormal_smooth_muscle0.63104938
188MP0009763_increased_sensitivity_to0.62614927
189MP0003303_peritoneal_inflammation0.62502933

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.62428419
2Abnormality of monocarboxylic acid metabolism (HP:0010996)4.48995573
3Premature rupture of membranes (HP:0001788)4.40831798
4Abnormality of midbrain morphology (HP:0002418)4.37146618
5Molar tooth sign on MRI (HP:0002419)4.37146618
6Pancreatic fibrosis (HP:0100732)4.25197312
7True hermaphroditism (HP:0010459)4.23974056
8Protrusio acetabuli (HP:0003179)4.18864631
9Nephronophthisis (HP:0000090)4.16715056
10Hypobetalipoproteinemia (HP:0003563)3.99939467
11Deep venous thrombosis (HP:0002625)3.80165346
12Congenital stationary night blindness (HP:0007642)3.76026192
13Xanthomatosis (HP:0000991)3.62784363
14Abnormality of pyrimidine metabolism (HP:0004353)3.62684820
15Intrahepatic cholestasis (HP:0001406)3.56452754
16Abnormality of the renal medulla (HP:0100957)3.45963643
17Hypolipoproteinemia (HP:0010981)3.42002192
18Tubular atrophy (HP:0000092)3.35380407
19Dynein arm defect of respiratory motile cilia (HP:0012255)3.34961626
20Absent/shortened dynein arms (HP:0200106)3.34961626
21Chronic hepatic failure (HP:0100626)3.33710304
22Abnormality of methionine metabolism (HP:0010901)3.23581835
23Furrowed tongue (HP:0000221)3.22647374
24Type II lissencephaly (HP:0007260)3.19870145
25Hypoalphalipoproteinemia (HP:0003233)3.19212221
26Congenital, generalized hypertrichosis (HP:0004540)3.18544575
27Abnormality of aromatic amino acid family metabolism (HP:0004338)3.11897693
28Biconcave vertebral bodies (HP:0004586)3.09488809
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.05781114
30Abnormality of alanine metabolism (HP:0010916)3.05781114
31Hyperalaninemia (HP:0003348)3.05781114
32Abnormality of the renal cortex (HP:0011035)3.05354626
33Attenuation of retinal blood vessels (HP:0007843)3.02598434
34Abnormal drinking behavior (HP:0030082)2.99632815
35Polydipsia (HP:0001959)2.99632815
36Myocardial infarction (HP:0001658)2.96429360
37Cystic liver disease (HP:0006706)2.94578930
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.92507731
39Concave nail (HP:0001598)2.92207580
40Abnormality of sulfur amino acid metabolism (HP:0004339)2.89967906
41Breast hypoplasia (HP:0003187)2.88778554
42Medial flaring of the eyebrow (HP:0010747)2.86124499
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.76274664
44Abnormality of the anterior horn cell (HP:0006802)2.66720949
45Degeneration of anterior horn cells (HP:0002398)2.66720949
46Hyperventilation (HP:0002883)2.65257530
47Abnormal respiratory epithelium morphology (HP:0012253)2.63775333
48Abnormal respiratory motile cilium morphology (HP:0005938)2.63775333
49Pendular nystagmus (HP:0012043)2.62055390
50Large for gestational age (HP:0001520)2.60002388
51Vertebral compression fractures (HP:0002953)2.59961310
52Sclerocornea (HP:0000647)2.58784700
53Prolonged partial thromboplastin time (HP:0003645)2.58666221
54Abnormal rod and cone electroretinograms (HP:0008323)2.58038071
55Keratoconus (HP:0000563)2.56123001
56Increased corneal curvature (HP:0100692)2.56123001
57Hypothermia (HP:0002045)2.55546339
58Decreased circulating renin level (HP:0003351)2.45179572
59Abnormal ciliary motility (HP:0012262)2.44770594
60Hyperammonemia (HP:0001987)2.43386515
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.42995809
62Aplasia/Hypoplasia of the tongue (HP:0010295)2.41789378
63Abnormality of complement system (HP:0005339)2.39038500
64Aplasia/hypoplasia of the uterus (HP:0008684)2.37141071
65Hyperlipoproteinemia (HP:0010980)2.35878901
66Abnormality of the intrinsic pathway (HP:0010989)2.34421385
67Osteolytic defects of the phalanges of the hand (HP:0009771)2.34378547
68Osteolytic defects of the hand bones (HP:0009699)2.34378547
69Cerebellar dysplasia (HP:0007033)2.32207622
70Short nail (HP:0001799)2.29827997
71Hyperglycinemia (HP:0002154)2.29440120
72Abnormal delivery (HP:0001787)2.29276008
73Abnormality of serum amino acid levels (HP:0003112)2.27048314
74Congenital hepatic fibrosis (HP:0002612)2.24888472
75Fat malabsorption (HP:0002630)2.24675332
76Soft skin (HP:0000977)2.23990339
77Male pseudohermaphroditism (HP:0000037)2.23856209
78Spastic diplegia (HP:0001264)2.23682722
79Polyuria (HP:0000103)2.21157550
80Abnormal respiratory motile cilium physiology (HP:0012261)2.20723157
81Anencephaly (HP:0002323)2.20233407
82Hepatocellular carcinoma (HP:0001402)2.19447245
83Erythroderma (HP:0001019)2.17794027
84Abnormality of nail color (HP:0100643)2.17681045
853-Methylglutaconic aciduria (HP:0003535)2.17528645
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.17515747
87Gait imbalance (HP:0002141)2.15529220
88Abnormal biliary tract physiology (HP:0012439)2.15302533
89Bile duct proliferation (HP:0001408)2.15302533
90Decreased central vision (HP:0007663)2.14900344
91Renal cortical cysts (HP:0000803)2.14790574
92Abolished electroretinogram (ERG) (HP:0000550)2.14323389
93Abnormal cartilage morphology (HP:0002763)2.14097487
94Nonimmune hydrops fetalis (HP:0001790)2.11829376
95Abnormal hemoglobin (HP:0011902)2.11480225
96Hypoplasia of the uterus (HP:0000013)2.10935862
97Complement deficiency (HP:0004431)2.10488500
98Epidermoid cyst (HP:0200040)2.10335530
99Congenital primary aphakia (HP:0007707)2.08779609
100Abnormality of the common coagulation pathway (HP:0010990)2.08660927
101Birth length less than 3rd percentile (HP:0003561)2.08612887
102Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07137986
103Blue sclerae (HP:0000592)2.07054994
104Abnormality of nucleobase metabolism (HP:0010932)2.06500026
105Chorioretinal atrophy (HP:0000533)2.05389984
106Amelogenesis imperfecta (HP:0000705)2.04695625
107Optic disc pallor (HP:0000543)2.04497755
108Breech presentation (HP:0001623)2.04410367
109Peritonitis (HP:0002586)2.04229112
110Abnormality of the umbilical cord (HP:0010881)2.03637546
111Natal tooth (HP:0000695)2.03070373
112Recurrent corneal erosions (HP:0000495)2.03063814
113Congenital sensorineural hearing impairment (HP:0008527)2.02033128
114Acute necrotizing encephalopathy (HP:0006965)2.02004833
115Trismus (HP:0000211)2.00496686
116Ankle contracture (HP:0006466)2.00481375
117Bony spicule pigmentary retinopathy (HP:0007737)1.99810217
118Nausea (HP:0002018)1.99781037
119Steatorrhea (HP:0002570)1.98609320
120Occipital encephalocele (HP:0002085)1.97495329
121Oral leukoplakia (HP:0002745)1.97444136
122Parakeratosis (HP:0001036)1.97223420
123Shallow orbits (HP:0000586)1.96172930
124Inability to walk (HP:0002540)1.95948630
125Severe muscular hypotonia (HP:0006829)1.95742370
126Skin nodule (HP:0200036)1.95122062
127Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.94742009
128Acute encephalopathy (HP:0006846)1.93288748
129Rough bone trabeculation (HP:0100670)1.93167250
130Wormian bones (HP:0002645)1.93121031
131Decreased electroretinogram (ERG) amplitude (HP:0000654)1.92885911
132Malnutrition (HP:0004395)1.92192862
133Esophageal varix (HP:0002040)1.91771639
134Conjunctival telangiectasia (HP:0000524)1.90899851
135Abnormality of the vasculature of the conjunctiva (HP:0008054)1.90228097
136Hypercholesterolemia (HP:0003124)1.89482728
137Aplasia/Hypoplasia of the patella (HP:0006498)1.89413698
138Abnormality of the pons (HP:0007361)1.88794340
139Mesangial abnormality (HP:0001966)1.88621986
140Hemiparesis (HP:0001269)1.87670946
141Cervical subluxation (HP:0003308)1.86818124
142Megaloblastic anemia (HP:0001889)1.84111535
143Palmoplantar hyperkeratosis (HP:0000972)1.83826745
144Mitochondrial inheritance (HP:0001427)1.82323753
145Nephrogenic diabetes insipidus (HP:0009806)1.82291140
146Limb dystonia (HP:0002451)1.81951205
147Secondary amenorrhea (HP:0000869)1.80691790
148Hypoplasia of the pons (HP:0012110)1.80638555
149Progressive macrocephaly (HP:0004481)1.79324307
150Postaxial foot polydactyly (HP:0001830)1.79122310
151Palmar hyperkeratosis (HP:0010765)1.78578564
152Fair hair (HP:0002286)1.77883170
153Abnormal urine output (HP:0012590)1.77706473
154Aortic aneurysm (HP:0004942)1.77527049
155Abnormality of serine family amino acid metabolism (HP:0010894)1.77209833
156Abnormality of glycine metabolism (HP:0010895)1.77209833
157Abnormality of renin-angiotensin system (HP:0000847)1.77161911
158Reticulocytopenia (HP:0001896)1.76761803
159Increased density of long bones (HP:0006392)1.76634653
160Aplasia/Hypoplasia of the tibia (HP:0005772)1.75628136
161Joint hemorrhage (HP:0005261)1.75295789
162Adrenal hypoplasia (HP:0000835)1.74690943
163Progressive inability to walk (HP:0002505)1.73787288
164Abnormalities of placenta or umbilical cord (HP:0001194)1.73461403
165Genital tract atresia (HP:0001827)1.73204112
166Clumsiness (HP:0002312)1.71353951
167Short hallux (HP:0010109)1.71309379
168Oligodactyly (hands) (HP:0001180)1.71155299
169Abnormal mitochondria in muscle tissue (HP:0008316)1.70987622
170Vaginal atresia (HP:0000148)1.70884760
171Cerebral aneurysm (HP:0004944)1.70652352
172Cortical dysplasia (HP:0002539)1.69792524
173Abnormality of the Achilles tendon (HP:0005109)1.69357842
174Deviation of the thumb (HP:0009603)1.69241772
175Fused cervical vertebrae (HP:0002949)1.68613502
176Lissencephaly (HP:0001339)1.68462493
177Back pain (HP:0003418)1.68422373
178Neonatal short-limb short stature (HP:0008921)1.68106609
179Congenital ichthyosiform erythroderma (HP:0007431)1.67524292
180Abnormal umbilical cord blood vessels (HP:0011403)1.67290016
181Single umbilical artery (HP:0001195)1.67290016
182Abnormality of the fetal cardiovascular system (HP:0010948)1.67290016
183Aortic dissection (HP:0002647)1.66992423
184Patellar aplasia (HP:0006443)1.66000307
185Increased connective tissue (HP:0009025)1.65933435
186Cardiovascular calcification (HP:0011915)1.65887819
187Selective tooth agenesis (HP:0001592)1.64064136
188Sparse lateral eyebrow (HP:0005338)1.60617928
189Abnormality of dentin (HP:0010299)1.60204043
190Abnormal trabecular bone morphology (HP:0100671)1.58460232
191Coronal craniosynostosis (HP:0004440)1.58183059
192Impulsivity (HP:0100710)1.57617895
193Absent radius (HP:0003974)1.57109929
194Abnormality of the distal phalanges of the toes (HP:0010182)1.57107387
195Spinal cord lesions (HP:0100561)1.57050004
196Syringomyelia (HP:0003396)1.57050004
197Dilatation of the ascending aorta (HP:0005111)1.56851598

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.24449259
2BUB13.80396474
3EIF2AK13.48505670
4ADRBK23.32547088
5NME23.16886756
6PNCK2.95027563
7CDC72.86701295
8BMPR1B2.82652875
9WEE12.81768141
10TESK22.80208330
11GRK12.68147025
12MAP4K22.62110941
13WNK42.47939275
14LATS22.39835688
15TESK12.37333785
16NEK12.33561210
17WNK32.29073145
18PINK12.12446753
19ZAK2.09570496
20EPHA22.06574379
21TTK2.03196926
22MAPK152.01716029
23LIMK11.91609943
24NEK21.91209358
25PLK41.90551082
26NEK91.85418819
27BCKDK1.84352584
28EIF2AK31.82302816
29STK391.78518562
30LATS11.72859351
31RPS6KA41.71663445
32MAPK131.67883666
33PKN21.61191406
34ADRBK11.60013110
35PLK11.58533191
36MAP3K81.56263680
37STK38L1.54899695
38PIM21.53318534
39DAPK21.52370208
40OXSR11.48684429
41PAK41.46042039
42CASK1.44280105
43BRSK21.43354936
44MOS1.42926178
45TAOK31.42751366
46AURKB1.36202484
47PBK1.35087254
48MAP3K101.34976433
49STK101.34875074
50KDR1.34784537
51MKNK21.34309490
52STK31.26937505
53SCYL21.26886136
54MKNK11.21422307
55PLK31.20515787
56ERN11.19223309
57PTK2B1.17023013
58RPS6KB21.16774028
59MAPKAPK51.13608668
60ERBB41.10485042
61AURKA1.09505976
62TLK11.08359536
63MAP3K41.06990441
64PAK21.05191096
65CDK71.05127453
66PHKG11.04381964
67PHKG21.04381964
68ABL21.03399988
69CHEK21.03186883
70MUSK0.97690662
71LRRK20.97608226
72TTN0.95048919
73PAK30.94931371
74CDK60.94218518
75PRKCG0.93903756
76MAP3K110.93291055
77CAMKK20.92279943
78CDK40.92225307
79NTRK30.91525438
80DYRK20.91047758
81NME10.88341741
82PRKCE0.88169188
83DDR20.86769572
84PAK10.86757389
85FGFR20.85164588
86RPS6KA50.84902335
87CSNK1G10.83724359
88EIF2AK20.83564749
89MST40.82579540
90BRAF0.82544349
91FLT30.80571476
92CSNK1G30.80501161
93MELK0.80461752
94ACVR1B0.78356368
95MST1R0.77242035
96ATR0.74919624
97CSNK1G20.73929180
98IRAK10.72186812
99TGFBR10.71454442
100PIK3CG0.70944713
101DYRK1B0.70833984
102TRIB30.70720037
103VRK10.70242976
104BRSK10.68871050
105MET0.68623578
106STK240.68165836
107TAOK20.67766816
108SRPK10.66963278
109STK40.66826851
110PRKCI0.63861227
111GRK70.63663552
112MAP3K30.63080038
113CDK120.63048890
114CSNK1A1L0.62775605
115MARK10.60929848
116FER0.60371174
117PRKCQ0.59472133
118TRPM70.59133778
119CAMK2A0.58917394
120MAP3K120.57340092
121IKBKB0.56910961
122FRK0.56704827
123EPHB20.56333700
124MAPKAPK30.55666555
125PIM10.54479380
126MAP3K50.54293229
127ERBB30.54156783
128TIE10.53859330
129MAP2K70.53722541
130PIK3CA0.53710610
131DAPK30.52414021
132CSNK2A10.52203639
133PTK20.52134324
134CHEK10.49494273
135ATM0.49063130
136CHUK0.48324635
137AKT30.47359062
138PTK60.46604279
139MAP2K10.45849647
140PRKACA0.44687459
141MTOR0.43682641
142SIK10.43534614
143ILK0.42860608
144ERBB20.41032027
145PDGFRA0.41031607
146KIT0.41016047
147CDK20.40388180
148NUAK10.39398922
149PRKCA0.38972364
150MAP2K60.38468660
151CSNK2A20.36051159
152OBSCN0.35543515
153CSNK1A10.34673694
154PLK20.32980459
155PASK0.32817785
156PRKCZ0.31829067
157TSSK60.31442373
158CDK80.31299924
159GRK50.30342242
160TNIK0.28495165
161SIK20.28243446
162PRKG10.28147856
163CSNK1D0.25291166
164TEC0.24994917
165IGF1R0.24638685
166PDK20.24389269
167DYRK1A0.24189525

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.38127572
2Linoleic acid metabolism_Homo sapiens_hsa005914.29285966
3One carbon pool by folate_Homo sapiens_hsa006702.94951134
4Ether lipid metabolism_Homo sapiens_hsa005652.81241355
5Phototransduction_Homo sapiens_hsa047442.70996714
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.53886590
7DNA replication_Homo sapiens_hsa030302.44706454
8Proteasome_Homo sapiens_hsa030502.43734729
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.42413823
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.39843128
11Oxidative phosphorylation_Homo sapiens_hsa001902.33728199
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.17805243
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.15243924
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.11911364
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09478489
16Mismatch repair_Homo sapiens_hsa034302.05781010
17Arachidonic acid metabolism_Homo sapiens_hsa005902.02655780
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96286643
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.92969863
20Nicotine addiction_Homo sapiens_hsa050331.91556477
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.90597579
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.88823799
23Arginine biosynthesis_Homo sapiens_hsa002201.88745683
24Selenocompound metabolism_Homo sapiens_hsa004501.82302902
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82246214
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80950464
27RNA transport_Homo sapiens_hsa030131.73204358
28Complement and coagulation cascades_Homo sapiens_hsa046101.72885247
29Ribosome_Homo sapiens_hsa030101.72726308
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.71540920
31Cell cycle_Homo sapiens_hsa041101.69898462
32Nitrogen metabolism_Homo sapiens_hsa009101.69772091
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.66810143
34Biosynthesis of amino acids_Homo sapiens_hsa012301.66265969
35Parkinsons disease_Homo sapiens_hsa050121.64060129
36Folate biosynthesis_Homo sapiens_hsa007901.59020804
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56561332
38p53 signaling pathway_Homo sapiens_hsa041151.51513856
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51263226
40Pyrimidine metabolism_Homo sapiens_hsa002401.50606379
41Sulfur relay system_Homo sapiens_hsa041221.48188794
42RNA polymerase_Homo sapiens_hsa030201.47767341
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47635838
44Tryptophan metabolism_Homo sapiens_hsa003801.45764816
45Nucleotide excision repair_Homo sapiens_hsa034201.44815698
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41589563
47Glutathione metabolism_Homo sapiens_hsa004801.41411703
48Protein export_Homo sapiens_hsa030601.39467985
49Chemical carcinogenesis_Homo sapiens_hsa052041.37397609
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36482570
51Vitamin B6 metabolism_Homo sapiens_hsa007501.34651569
52Base excision repair_Homo sapiens_hsa034101.32741455
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32118872
54Carbon metabolism_Homo sapiens_hsa012001.25312253
55Homologous recombination_Homo sapiens_hsa034401.24037424
56Fatty acid degradation_Homo sapiens_hsa000711.23056702
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21636931
58Alzheimers disease_Homo sapiens_hsa050101.21352852
59Taste transduction_Homo sapiens_hsa047421.20757203
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19436931
61Retinol metabolism_Homo sapiens_hsa008301.19141250
62Huntingtons disease_Homo sapiens_hsa050161.14730308
63Olfactory transduction_Homo sapiens_hsa047401.14125030
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13014546
65Cardiac muscle contraction_Homo sapiens_hsa042601.12131292
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10310044
67Cyanoamino acid metabolism_Homo sapiens_hsa004601.10154587
68Staphylococcus aureus infection_Homo sapiens_hsa051501.08431550
69Spliceosome_Homo sapiens_hsa030401.08063420
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07805277
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01447010
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01406638
73Peroxisome_Homo sapiens_hsa041460.96519829
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.95899956
75Serotonergic synapse_Homo sapiens_hsa047260.95459046
76Morphine addiction_Homo sapiens_hsa050320.95019728
77Phenylalanine metabolism_Homo sapiens_hsa003600.92882567
78Ovarian steroidogenesis_Homo sapiens_hsa049130.92797939
79Pentose phosphate pathway_Homo sapiens_hsa000300.92605227
80Caffeine metabolism_Homo sapiens_hsa002320.92324666
81Regulation of autophagy_Homo sapiens_hsa041400.91123961
82Circadian entrainment_Homo sapiens_hsa047130.89408290
83ABC transporters_Homo sapiens_hsa020100.88876900
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87150355
85Mineral absorption_Homo sapiens_hsa049780.86216795
86Sulfur metabolism_Homo sapiens_hsa009200.83738916
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83482783
88Steroid biosynthesis_Homo sapiens_hsa001000.82266036
89Arginine and proline metabolism_Homo sapiens_hsa003300.81061314
90Glutamatergic synapse_Homo sapiens_hsa047240.80322506
91PPAR signaling pathway_Homo sapiens_hsa033200.80003132
92Fat digestion and absorption_Homo sapiens_hsa049750.78879607
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.78400585
94Bladder cancer_Homo sapiens_hsa052190.77482892
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.76363216
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75732903
97Insulin secretion_Homo sapiens_hsa049110.75603122
98Collecting duct acid secretion_Homo sapiens_hsa049660.73347690
99Tyrosine metabolism_Homo sapiens_hsa003500.73179870
100Dorso-ventral axis formation_Homo sapiens_hsa043200.72488434
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.71362218
102Histidine metabolism_Homo sapiens_hsa003400.70751494
103Starch and sucrose metabolism_Homo sapiens_hsa005000.69922449
104Pyruvate metabolism_Homo sapiens_hsa006200.68025623
105Fructose and mannose metabolism_Homo sapiens_hsa000510.65946223
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64742694
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64525793
108Salivary secretion_Homo sapiens_hsa049700.63793578
109Calcium signaling pathway_Homo sapiens_hsa040200.63687560
110beta-Alanine metabolism_Homo sapiens_hsa004100.63561355
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63552979
112GABAergic synapse_Homo sapiens_hsa047270.61902251
113Fanconi anemia pathway_Homo sapiens_hsa034600.61674222
114Non-homologous end-joining_Homo sapiens_hsa034500.60087792
115Propanoate metabolism_Homo sapiens_hsa006400.59817893
116Systemic lupus erythematosus_Homo sapiens_hsa053220.59575244
117Cocaine addiction_Homo sapiens_hsa050300.59050475
118Long-term depression_Homo sapiens_hsa047300.58811679
119Glycerolipid metabolism_Homo sapiens_hsa005610.58146686
120Butanoate metabolism_Homo sapiens_hsa006500.57784298
121Circadian rhythm_Homo sapiens_hsa047100.56897192
122Vitamin digestion and absorption_Homo sapiens_hsa049770.56500551
123RNA degradation_Homo sapiens_hsa030180.56219542
124TGF-beta signaling pathway_Homo sapiens_hsa043500.55738550
125Epstein-Barr virus infection_Homo sapiens_hsa051690.54817458
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53649674
127Fatty acid metabolism_Homo sapiens_hsa012120.53501735
128Legionellosis_Homo sapiens_hsa051340.52763903
129MicroRNAs in cancer_Homo sapiens_hsa052060.51661996
130Small cell lung cancer_Homo sapiens_hsa052220.51636152
131Adherens junction_Homo sapiens_hsa045200.50383701
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49600710
133Basal transcription factors_Homo sapiens_hsa030220.47401288
134Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45983091
135Proteoglycans in cancer_Homo sapiens_hsa052050.45921355
136Viral carcinogenesis_Homo sapiens_hsa052030.45547415
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45314796
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44945440
139Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44944634
140Amphetamine addiction_Homo sapiens_hsa050310.44378669
141Sphingolipid metabolism_Homo sapiens_hsa006000.43993139
142Galactose metabolism_Homo sapiens_hsa000520.42165390
143Shigellosis_Homo sapiens_hsa051310.42054268
144Hippo signaling pathway_Homo sapiens_hsa043900.41787239
145Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40208005
146Metabolic pathways_Homo sapiens_hsa011000.39250626
147Purine metabolism_Homo sapiens_hsa002300.39194580
148Apoptosis_Homo sapiens_hsa042100.38264964
149Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37865644
150Hedgehog signaling pathway_Homo sapiens_hsa043400.35651438
151Glycosaminoglycan degradation_Homo sapiens_hsa005310.35021663
152Fatty acid biosynthesis_Homo sapiens_hsa000610.34940228
153Dopaminergic synapse_Homo sapiens_hsa047280.33950951
154Asthma_Homo sapiens_hsa053100.31617133
155Antigen processing and presentation_Homo sapiens_hsa046120.31143123
156Lysine degradation_Homo sapiens_hsa003100.30869905
157Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29527805

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