RAET1G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the major histocompatibility complex (MHC) class I family of proteins. Although the encoded protein includes C-terminal transmembrane and cytoplasmic domains, proteolytic processing results in the removal of these domains and subsequent tethering to the plasma membrane by a glycosylphosphatidylinositol (GPI)-anchor. The encoded protein is one of several related ligands of the natural killer group 2, member D (NKG2D) receptor, which functions as an activating receptor in innate and adaptive immunity. This gene is present in a gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.34104299
2keratinocyte proliferation (GO:0043616)6.09391582
3cell-substrate junction assembly (GO:0007044)6.00831636
4cell adhesion mediated by integrin (GO:0033627)5.26231735
5bundle of His cell to Purkinje myocyte communication (GO:0086069)5.14846134
6negative regulation of keratinocyte proliferation (GO:0010839)4.93292220
7facial nerve structural organization (GO:0021612)4.73042896
8dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.64297118
9establishment of skin barrier (GO:0061436)4.44747627
10regulation of water loss via skin (GO:0033561)4.28016994
11keratinization (GO:0031424)4.10099707
12type B pancreatic cell proliferation (GO:0044342)4.01673556
13regulation of keratinocyte proliferation (GO:0010837)3.99068267
14positive regulation of epidermis development (GO:0045684)3.89400009
15positive regulation of epidermal cell differentiation (GO:0045606)3.84568605
16regulation of interleukin-8 secretion (GO:2000482)3.84393389
17membrane raft organization (GO:0031579)3.81504966
18negative regulation of chondrocyte differentiation (GO:0032331)3.71128740
19intermediate filament organization (GO:0045109)3.67604451
20regulation of hair follicle development (GO:0051797)3.64230856
21protein localization to endosome (GO:0036010)3.59573843
22skin morphogenesis (GO:0043589)3.58181561
23mesodermal cell differentiation (GO:0048333)3.57716508
24positive regulation of hair cycle (GO:0042635)3.57080693
25positive regulation of hair follicle development (GO:0051798)3.57080693
26cellular copper ion homeostasis (GO:0006878)3.57020714
27cellular response to zinc ion (GO:0071294)3.51847762
28muscle cell migration (GO:0014812)3.50912393
29heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.47067028
30epidermis development (GO:0008544)3.42376156
31COPI coating of Golgi vesicle (GO:0048205)3.37481885
32Golgi transport vesicle coating (GO:0048200)3.37481885
33maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.28112606
34membrane budding (GO:0006900)3.22483457
35regulation of metalloenzyme activity (GO:0048552)3.21616322
36artery development (GO:0060840)3.18774393
37polyamine biosynthetic process (GO:0006596)3.15287834
38surfactant homeostasis (GO:0043129)3.11702599
39gap junction assembly (GO:0016264)3.10236627
40protein retention in ER lumen (GO:0006621)3.08547296
41cranial nerve structural organization (GO:0021604)3.08332455
42regulation of phospholipase A2 activity (GO:0032429)3.07930400
43axon extension involved in axon guidance (GO:0048846)3.05218850
44neuron projection extension involved in neuron projection guidance (GO:1902284)3.05218850
45protein maturation by protein folding (GO:0022417)3.05170713
46hypotonic response (GO:0006971)3.04577090
47hair cycle (GO:0042633)3.04428763
48molting cycle (GO:0042303)3.04428763
49cellular response to vitamin D (GO:0071305)3.03295157
50positive regulation of keratinocyte differentiation (GO:0045618)3.02188654
51ectoderm development (GO:0007398)3.01481977
52negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.01360002
53keratinocyte differentiation (GO:0030216)3.00696492
54endodermal cell differentiation (GO:0035987)2.98734132
55barbed-end actin filament capping (GO:0051016)2.97517612
56negative regulation of stem cell proliferation (GO:2000647)2.94095715
57mammary gland development (GO:0030879)2.91586793
58regulation of epidermis development (GO:0045682)2.90138673
59substrate-dependent cell migration (GO:0006929)2.90132024
60regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.88586704
61endothelial cell chemotaxis (GO:0035767)2.88287464
62protein heterotetramerization (GO:0051290)2.87306937
63nuclear envelope reassembly (GO:0031468)2.85327177
64mitotic nuclear envelope reassembly (GO:0007084)2.85327177
65positive regulation of interleukin-8 secretion (GO:2000484)2.84037571
66keratinocyte development (GO:0003334)2.79200942
67establishment of planar polarity (GO:0001736)2.76843151
68establishment of tissue polarity (GO:0007164)2.76843151
69negative regulation of nitric-oxide synthase activity (GO:0051001)2.76811508
70cellular response to vitamin (GO:0071295)2.72400847
71regulation of transforming growth factor beta2 production (GO:0032909)2.70828006
72cell junction assembly (GO:0034329)2.67341076
73ganglion development (GO:0061548)2.66067401
74multicellular organismal water homeostasis (GO:0050891)2.63266059
75regulation of keratinocyte differentiation (GO:0045616)2.62981396
76extracellular fibril organization (GO:0043206)2.62740414
77wound healing, spreading of epidermal cells (GO:0035313)2.61895551
78intermediate filament cytoskeleton organization (GO:0045104)2.61061287
79copper ion homeostasis (GO:0055070)2.58029380
80regulation of transforming growth factor beta1 production (GO:0032908)2.55552911
81intermediate filament-based process (GO:0045103)2.54148703
82AMP metabolic process (GO:0046033)2.53171210
83neural crest cell development (GO:0014032)2.52267796
84polarized epithelial cell differentiation (GO:0030859)2.51869808
85low-density lipoprotein particle clearance (GO:0034383)2.51856354
86chemical homeostasis within a tissue (GO:0048875)2.50058335
87mammary gland epithelial cell proliferation (GO:0033598)2.49614235
88pattern specification involved in kidney development (GO:0061004)2.49457861
89L-serine transport (GO:0015825)2.48300499
90regulation of cardioblast differentiation (GO:0051890)2.47604570
91negative regulation of cartilage development (GO:0061037)2.46852467
92renal system development (GO:0072001)2.46591686
93hepatocyte differentiation (GO:0070365)2.46547967
94cell junction organization (GO:0034330)2.45718533
95cell-substrate adherens junction assembly (GO:0007045)2.45629318
96focal adhesion assembly (GO:0048041)2.45629318
97regulation of G0 to G1 transition (GO:0070316)2.45574404
98anatomical structure arrangement (GO:0048532)2.45347480
99protein localization to cell surface (GO:0034394)2.44644539
100hemidesmosome assembly (GO:0031581)14.5552512

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.94276624
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human5.24190170
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.69160259
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.36362297
5SMAD3_18955504_ChIP-ChIP_HaCaT_Human3.32715382
6SMAD2_18955504_ChIP-ChIP_HaCaT_Human3.32715382
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.72582498
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.71698373
9ZNF263_19887448_ChIP-Seq_K562_Human2.67684039
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.42582901
11P63_26484246_Chip-Seq_KERATINOCYTES_Human2.40860964
12ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.36097897
13CJUN_26792858_Chip-Seq_BT549_Human2.08886170
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.01627571
15TP63_17297297_ChIP-ChIP_HaCaT_Human13.8346952
16KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.93275765
17JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.87770632
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83389691
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.78104475
20JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.77584054
21UBF1/2_26484160_Chip-Seq_HMECs_Human1.75902624
22ATF3_27146783_Chip-Seq_COLON_Human1.75599420
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.68926355
24SOX2_20726797_ChIP-Seq_SW620_Human1.67462225
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66170257
26SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.63217334
27KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.59714214
28PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58991283
29HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.58425804
30CLOCK_20551151_ChIP-Seq_293T_Human1.57005658
31SOX9_24532713_ChIP-Seq_HFSC_Mouse1.55617491
32TP53_18474530_ChIP-ChIP_U2OS_Human1.52526916
33UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.52024397
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45277879
35KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45261904
36FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.37471031
37ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37254491
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33633329
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.32693367
40BRD4_25478319_ChIP-Seq_HGPS_Human1.28402258
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28213879
42TP63_23658742_ChIP-Seq_EP156T_Human1.28197592
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22517213
44RACK7_27058665_Chip-Seq_MCF-7_Human1.20985546
45CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20329473
46ELK1_22589737_ChIP-Seq_MCF10A_Human1.20222506
47P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20174015
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17824828
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17807594
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.15866453
51TP53_22127205_ChIP-Seq_IMR90_Human1.15362167
52* TP63_22573176_ChIP-Seq_HFKS_Human1.05792059
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04349756
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03618155
55AR_21909140_ChIP-Seq_LNCAP_Human1.03609733
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02881585
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01983134
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.00016065
59EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99300592
60ESR1_20079471_ChIP-ChIP_T-47D_Human0.90736387
61DCP1A_22483619_ChIP-Seq_HELA_Human0.90606664
62GATA3_24758297_ChIP-Seq_MCF-7_Human0.89789738
63MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.89241749
64GATA6_25053715_ChIP-Seq_YYC3_Human0.87744691
65SMAD_19615063_ChIP-ChIP_OVARY_Human0.86797716
66E2F1_18555785_ChIP-Seq_MESCs_Mouse0.84891114
67TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84574059
68EOMES_21245162_ChIP-Seq_HESCs_Human0.84260929
69EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.83896086
70NELFA_20434984_ChIP-Seq_ESCs_Mouse0.82966908
71GABP_17652178_ChIP-ChIP_JURKAT_Human0.80320342
72PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.78410580
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.78121711
74GATA4_25053715_ChIP-Seq_YYC3_Human0.77203445
75CDX2_20551321_ChIP-Seq_CACO-2_Human0.77102279
76KLF5_25053715_ChIP-Seq_YYC3_Human0.76304537
77FOXO3_23340844_ChIP-Seq_DLD1_Human0.76077822
78ELF5_23300383_ChIP-Seq_T47D_Human0.75472670
79ZNF217_24962896_ChIP-Seq_MCF-7_Human0.74977900
80TP53_23651856_ChIP-Seq_MEFs_Mouse0.74278942
81KLF4_18555785_ChIP-Seq_MESCs_Mouse0.73909214
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.73703930
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.73514844
84PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.73500262
85TET1_21490601_ChIP-Seq_MESCs_Mouse0.72683305
86TBX20_22080862_ChIP-Seq_HEART_Mouse0.72682658
87TBX20_22328084_ChIP-Seq_HEART_Mouse0.72682658
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.71440968
89SOX17_20123909_ChIP-Seq_XEN_Mouse0.71278392
90MYC_18358816_ChIP-ChIP_MESCs_Mouse0.71078259
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.68619144
92NANOG_18555785_ChIP-Seq_MESCs_Mouse0.68026854
93TBX5_21415370_ChIP-Seq_HL-1_Mouse0.68009609
94CSB_26484114_Chip-Seq_FIBROBLAST_Human0.67176763
95EP300_21415370_ChIP-Seq_HL-1_Mouse0.67168450
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.66348976
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.65989317
98SOX2_27498859_Chip-Seq_STOMACH_Mouse0.65262553
99TET1_21451524_ChIP-Seq_MESCs_Mouse0.64918401
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62286180

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology6.22820832
2MP0004272_abnormal_basement_membrane3.68324683
3MP0000762_abnormal_tongue_morphology3.53331658
4MP0010234_abnormal_vibrissa_follicle3.44440126
5MP0005275_abnormal_skin_tensile3.28461966
6MP0003566_abnormal_cell_adhesion3.27226495
7MP0003941_abnormal_skin_development3.26426373
8MP0002796_impaired_skin_barrier3.11267254
9MP0002060_abnormal_skin_morphology3.05728439
10MP0003705_abnormal_hypodermis_morpholog3.04254595
11MP0003950_abnormal_plasma_membrane2.78671162
12MP0000467_abnormal_esophagus_morphology2.73120089
13MP0001216_abnormal_epidermal_layer2.53688110
14MP0008438_abnormal_cutaneous_collagen2.42635727
15MP0003315_abnormal_perineum_morphology2.35713557
16MP0005501_abnormal_skin_physiology2.32551291
17MP0000678_abnormal_parathyroid_gland2.29308224
18MP0009053_abnormal_anal_canal2.28701977
19MP0001849_ear_inflammation2.25021613
20MP0002234_abnormal_pharynx_morphology2.21412423
21MP0002098_abnormal_vibrissa_morphology2.13594969
22MP0005023_abnormal_wound_healing2.13580076
23MP0003453_abnormal_keratinocyte_physiol2.11589532
24MP0005451_abnormal_body_composition2.09918560
25MP0010678_abnormal_skin_adnexa1.99164822
26MP0000537_abnormal_urethra_morphology1.94040526
27MP0005257_abnormal_intraocular_pressure1.86068093
28MP0010771_integument_phenotype1.85492828
29MP0003806_abnormal_nucleotide_metabolis1.81164739
30MP0008260_abnormal_autophagy1.79074802
31MP0010030_abnormal_orbit_morphology1.76732584
32MP0002877_abnormal_melanocyte_morpholog1.69942075
33MP0010368_abnormal_lymphatic_system1.68514246
34MP0003191_abnormal_cellular_cholesterol1.66848570
35MP0000383_abnormal_hair_follicle1.57450775
36MP0005623_abnormal_meninges_morphology1.43686212
37MP0000377_abnormal_hair_follicle1.42733860
38MP0006054_spinal_hemorrhage1.40672113
39MP0005409_darkened_coat_color1.37343549
40MP0009840_abnormal_foam_cell1.29577518
41MP0005360_urolithiasis1.29277381
42MP0001299_abnormal_eye_distance/1.22187543
43MP0004381_abnormal_hair_follicle1.22081288
44MP0009931_abnormal_skin_appearance1.16965551
45MP0000749_muscle_degeneration1.14152907
46MP0003755_abnormal_palate_morphology1.13749732
47MP0002282_abnormal_trachea_morphology1.12062747
48MP0000627_abnormal_mammary_gland1.11947508
49MP0000566_synostosis1.10725855
50MP0009780_abnormal_chondrocyte_physiolo1.10380648
51MP0008007_abnormal_cellular_replicative1.07974263
52MP0000750_abnormal_muscle_regeneration1.07269601
53MP0000427_abnormal_hair_cycle1.04473390
54MP0000538_abnormal_urinary_bladder1.02116033
55MP0002295_abnormal_pulmonary_circulatio0.99475041
56MP0001879_abnormal_lymphatic_vessel0.97966231
57MP0004233_abnormal_muscle_weight0.97907848
58MP0002177_abnormal_outer_ear0.97349846
59MP0001243_abnormal_dermal_layer0.97042896
60MP0001958_emphysema0.96661449
61MP0005330_cardiomyopathy0.95429545
62MP0008932_abnormal_embryonic_tissue0.94837950
63MP0004264_abnormal_extraembryonic_tissu0.93807311
64MP0001542_abnormal_bone_strength0.92607527
65MP0005165_increased_susceptibility_to0.92545482
66MP0003091_abnormal_cell_migration0.91917142
67MP0000013_abnormal_adipose_tissue0.91377828
68MP0000733_abnormal_muscle_development0.90737709
69MP0008789_abnormal_olfactory_epithelium0.88355339
70MP0002896_abnormal_bone_mineralization0.88326052
71MP0001191_abnormal_skin_condition0.88034798
72MP0003786_premature_aging0.86291123
73MP0000647_abnormal_sebaceous_gland0.85934804
74MP0003385_abnormal_body_wall0.85268555
75MP0000858_altered_metastatic_potential0.85144846
76MP0005197_abnormal_uvea_morphology0.79664397
77MP0000367_abnormal_coat/_hair0.77699795
78MP0001340_abnormal_eyelid_morphology0.75761581
79MP0000751_myopathy0.74857456
80MP0005164_abnormal_response_to0.74809397
81MP0000767_abnormal_smooth_muscle0.67585762
82MP0010352_gastrointestinal_tract_polyps0.67055222
83MP0006138_congestive_heart_failure0.65730089
84MP0009250_abnormal_appendicular_skeleto0.65575271
85MP0004947_skin_inflammation0.65050898
86MP0001661_extended_life_span0.64440853
87MP0003279_aneurysm0.64439327
88MP0005508_abnormal_skeleton_morphology0.61820510
89MP0002233_abnormal_nose_morphology0.60279241
90MP0005083_abnormal_biliary_tract0.58846354
91MP0002111_abnormal_tail_morphology0.58426181
92MP0005193_abnormal_anterior_eye0.58085808
93MP0005621_abnormal_cell_physiology0.56054082
94MP0000049_abnormal_middle_ear0.53375671
95MP0004782_abnormal_surfactant_physiolog0.52952330
96MP0005367_renal/urinary_system_phenotyp0.52501103
97MP0000516_abnormal_urinary_system0.52501103
98MP0005058_abnormal_lysosome_morphology0.52272655
99MP0005410_abnormal_fertilization0.49936562
100MP0000003_abnormal_adipose_tissue0.49675587

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)7.61616547
2Milia (HP:0001056)7.53376851
3Fragile nails (HP:0001808)7.00553285
4Atrophic scars (HP:0001075)6.90151660
5Abnormality of nail color (HP:0100643)6.85874572
6Plantar hyperkeratosis (HP:0007556)6.70661777
7Thick nail (HP:0001805)5.58186751
8Alopecia of scalp (HP:0002293)5.57287978
9Nail dystrophy (HP:0008404)5.09162294
10Palmoplantar hyperkeratosis (HP:0000972)4.89555370
11Right ventricular cardiomyopathy (HP:0011663)4.83246371
12Short nail (HP:0001799)4.69011337
13Palmar hyperkeratosis (HP:0010765)4.54274703
14Fragile skin (HP:0001030)4.31169455
15Pili torti (HP:0003777)3.90382996
16Ridged nail (HP:0001807)3.73903534
17Natal tooth (HP:0000695)3.63627846
18Abnormal hair laboratory examination (HP:0003328)3.53105978
19Abnormal blistering of the skin (HP:0008066)3.38509035
20Oral leukoplakia (HP:0002745)3.36640121
21Sparse scalp hair (HP:0002209)3.34247774
22Sparse eyelashes (HP:0000653)3.34163551
23Premature rupture of membranes (HP:0001788)3.13549381
24Follicular hyperkeratosis (HP:0007502)3.11916205
25Selective tooth agenesis (HP:0001592)3.07491888
26Pterygium (HP:0001059)2.95857555
27Hypoplasia of dental enamel (HP:0006297)2.94733065
28Hypotrichosis (HP:0001006)2.83393086
29Abnormality of placental membranes (HP:0011409)2.80571737
30Amniotic constriction ring (HP:0009775)2.80571737
3111 pairs of ribs (HP:0000878)2.79975890
32Aplasia cutis congenita (HP:0001057)2.79006473
33Spinal cord compression (HP:0002176)2.75879897
34Lip pit (HP:0100267)2.49232553
35Dry hair (HP:0011359)2.47869178
36Absent eyelashes (HP:0000561)2.47409063
37Vascular calcification (HP:0004934)2.46498383
38Reduced subcutaneous adipose tissue (HP:0003758)2.45967625
39Abnormality of carpal bone ossification (HP:0006257)2.42388543
40Cardiovascular calcification (HP:0011915)2.41371626
41Hypoplasia of the uterus (HP:0000013)2.38536674
42Ankyloglossia (HP:0010296)2.37796862
43Popliteal pterygium (HP:0009756)2.37765277
44Erythema (HP:0010783)2.32963132
45Osteolytic defects of the hand bones (HP:0009699)2.30810058
46Osteolytic defects of the phalanges of the hand (HP:0009771)2.30810058
47Woolly hair (HP:0002224)2.30714613
48Advanced eruption of teeth (HP:0006288)2.30614307
49Ectropion (HP:0000656)2.30005528
50Hypodontia (HP:0000668)2.23209109
51Congenital ichthyosiform erythroderma (HP:0007431)2.16304911
52Cervical subluxation (HP:0003308)2.14374816
53Delayed gross motor development (HP:0002194)2.14281160
54Spinal rigidity (HP:0003306)2.14266635
55Abnormality of the distal phalanges of the toes (HP:0010182)2.09866211
56Anonychia (HP:0001798)2.08930108
57Squamous cell carcinoma (HP:0002860)2.07678141
58Hyperhidrosis (HP:0000975)2.06839659
59Abnormality of oral frenula (HP:0000190)2.04528391
60Carious teeth (HP:0000670)2.03000950
61Difficulty climbing stairs (HP:0003551)2.02926669
62Corneal erosion (HP:0200020)2.00558752
63Palmoplantar keratoderma (HP:0000982)2.00133361
64Abnormal ossification of hand bones (HP:0005921)1.97951294
65Trismus (HP:0000211)1.93789663
66Corneal dystrophy (HP:0001131)1.93340522
67Radial bowing (HP:0002986)1.92845655
68Oligodontia (HP:0000677)1.87327979
69Broad distal phalanx of finger (HP:0009836)1.85283723
70Elbow flexion contracture (HP:0002987)1.84402822
71Back pain (HP:0003418)1.83990085
72Acanthosis nigricans (HP:0000956)1.82442847
73Congenital, generalized hypertrichosis (HP:0004540)1.78985081
74Abnormality of the fingernails (HP:0001231)1.77999005
75Aplasia/hypoplasia of the uterus (HP:0008684)1.77022589
76Abnormal hand bone ossification (HP:0010660)1.76010049
77Broad face (HP:0000283)1.73374066
78Hydroureter (HP:0000072)1.72413786
79Fatigable weakness (HP:0003473)1.72097134
80Abnormality of the neuromuscular junction (HP:0003398)1.72097134
81Ventricular tachycardia (HP:0004756)1.70482662
82Abnormalities of placenta or umbilical cord (HP:0001194)1.68477334
83Bowed forearm bones (HP:0003956)1.67803499
84Bowing of the arm (HP:0006488)1.67803499
85Vertebral compression fractures (HP:0002953)1.66872225
86Breast hypoplasia (HP:0003187)1.65217660
87Hypoplastic labia majora (HP:0000059)1.65126791
88Hoarse voice (HP:0001609)1.63864402
89Axonal loss (HP:0003447)1.61681256
90Glucose intolerance (HP:0000833)1.60188437
91Rough bone trabeculation (HP:0100670)1.60139484
92Vascular tortuosity (HP:0004948)1.59270476
93Protrusio acetabuli (HP:0003179)1.59168246
94Entropion (HP:0000621)1.58593092
95Erythroderma (HP:0001019)1.58540886
96Arterial tortuosity (HP:0005116)1.57799077
97Microglossia (HP:0000171)1.53184418
98Neurofibrillary tangles (HP:0002185)1.52019752
99Distal lower limb muscle weakness (HP:0009053)1.50960278
100Laryngomalacia (HP:0001601)1.48787930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.93147890
2EPHA24.43677100
3ARAF3.92040230
4EPHB23.28921302
5MET3.18428105
6NME23.06956649
7TESK12.93338502
8PIM22.84063296
9LMTK22.56055157
10LIMK12.51060390
11MAP3K22.38054881
12MYLK2.00687158
13PTK21.99133204
14NTRK11.73935149
15MAP3K121.69022463
16IRAK31.66825566
17PBK1.66118537
18TESK21.60399598
19PAK41.59482368
20LATS21.49457043
21MST41.41393587
22MAPKAPK31.40263305
23SIK11.34976018
24RIPK11.32999391
25RAF11.31608585
26MOS1.27253549
27TSSK61.26583296
28MAP3K31.26332679
29KSR21.21022257
30PINK11.19011086
31LATS11.18649244
32BRAF1.13202988
33TGFBR11.12421858
34BUB11.11056962
35VRK21.10737063
36FLT31.07079687
37ABL21.05733193
38STK101.04046283
39MAP3K91.01834717
40TGFBR21.01752099
41PDGFRA1.01424313
42CSNK1A1L1.01077692
43CSNK1G30.99374358
44ILK0.98759402
45STK38L0.96997278
46ERBB40.92731027
47TTN0.91389103
48EIF2AK30.86185901
49PRKCI0.85264861
50TRPM70.84901092
51TLK10.84042295
52STK240.82225024
53STK380.82210881
54NEK10.80612930
55MAP2K70.71790635
56ROCK10.71308041
57PAK20.70852889
58FER0.70501708
59DAPK10.66556178
60PTK2B0.65679159
61ADRBK10.64638380
62CSNK1G10.64581384
63KSR10.59886378
64GRK50.59477446
65MAPK150.59235126
66GRK70.57724225
67ROCK20.56182687
68ERBB30.55759926
69MAP3K80.55040038
70BMX0.53652438
71STK160.53095346
72PAK10.52066947
73CSNK1G20.52022782
74BRSK10.51202136
75AURKA0.50609363
76DDR20.50315260
77BRSK20.49797866
78PHKG20.48800995
79PHKG10.48800995
80PRKG20.48148299
81MAP2K10.46978232
82CAMK2G0.45247279
83CDK80.45142728
84RPS6KA50.44220074
85ERN10.44112103
86CLK10.43129869
87MAP3K10.41337579
88TRIB30.39436533
89DAPK30.39435151
90GRK10.38008590
91MAPKAPK50.37628148
92SMG10.37058193
93MAP3K60.36615003
94PDK20.35594797
95MARK30.30970981
96NEK90.28886157
97AURKB0.28105176
98ICK0.27595759
99TIE10.27363594
100MAPKAPK20.27085355

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.70066055
2ECM-receptor interaction_Homo sapiens_hsa045123.66084554
3Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.88374937
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.52907634
5Proteasome_Homo sapiens_hsa030502.49367504
6Sulfur metabolism_Homo sapiens_hsa009202.47283825
7Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.43383873
8Steroid biosynthesis_Homo sapiens_hsa001002.16473185
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.12412094
10Focal adhesion_Homo sapiens_hsa045102.10415881
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.04640770
12Small cell lung cancer_Homo sapiens_hsa052221.89455566
13Galactose metabolism_Homo sapiens_hsa000521.88515118
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.82702121
15Sphingolipid metabolism_Homo sapiens_hsa006001.75169567
16N-Glycan biosynthesis_Homo sapiens_hsa005101.73180421
17p53 signaling pathway_Homo sapiens_hsa041151.64008215
18Glutathione metabolism_Homo sapiens_hsa004801.55098165
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.52587277
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.49358284
21Bladder cancer_Homo sapiens_hsa052191.44930450
22Fatty acid elongation_Homo sapiens_hsa000621.41666538
23Proteoglycans in cancer_Homo sapiens_hsa052051.35712601
24Sulfur relay system_Homo sapiens_hsa041221.34995751
25Pyrimidine metabolism_Homo sapiens_hsa002401.34879973
26Mineral absorption_Homo sapiens_hsa049781.34283749
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28441840
28Adherens junction_Homo sapiens_hsa045201.26032299
29Pentose phosphate pathway_Homo sapiens_hsa000301.25752300
30Shigellosis_Homo sapiens_hsa051311.21336522
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19928153
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.18143045
33Fructose and mannose metabolism_Homo sapiens_hsa000511.17689723
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16373152
35Amoebiasis_Homo sapiens_hsa051461.15554912
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12768961
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12641953
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.10509662
39Vibrio cholerae infection_Homo sapiens_hsa051101.09224079
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08106875
41Apoptosis_Homo sapiens_hsa042101.07529005
42Dilated cardiomyopathy_Homo sapiens_hsa054141.07437575
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05539477
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04619289
45Hippo signaling pathway_Homo sapiens_hsa043901.01885573
46Axon guidance_Homo sapiens_hsa043600.99901779
47TGF-beta signaling pathway_Homo sapiens_hsa043500.96173278
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95956322
49Alzheimers disease_Homo sapiens_hsa050100.89793171
50Nucleotide excision repair_Homo sapiens_hsa034200.85296150
51Prion diseases_Homo sapiens_hsa050200.84260163
52Biosynthesis of amino acids_Homo sapiens_hsa012300.82333357
53Thyroid cancer_Homo sapiens_hsa052160.80909370
54Vitamin B6 metabolism_Homo sapiens_hsa007500.79181663
55Arginine and proline metabolism_Homo sapiens_hsa003300.78903850
56Endocytosis_Homo sapiens_hsa041440.78878214
57RNA polymerase_Homo sapiens_hsa030200.77321685
58Salmonella infection_Homo sapiens_hsa051320.76333434
59Circadian rhythm_Homo sapiens_hsa047100.73176771
60PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72468882
61Phenylalanine metabolism_Homo sapiens_hsa003600.71573536
62Folate biosynthesis_Homo sapiens_hsa007900.70962575
63Lysosome_Homo sapiens_hsa041420.68788636
64ErbB signaling pathway_Homo sapiens_hsa040120.67799317
65Pyruvate metabolism_Homo sapiens_hsa006200.66105457
66Hedgehog signaling pathway_Homo sapiens_hsa043400.65064898
67Melanoma_Homo sapiens_hsa052180.64133969
68DNA replication_Homo sapiens_hsa030300.63976483
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60895499
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58294119
71Pathways in cancer_Homo sapiens_hsa052000.57914374
72Gap junction_Homo sapiens_hsa045400.57125661
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56823297
74Tight junction_Homo sapiens_hsa045300.56681033
75MicroRNAs in cancer_Homo sapiens_hsa052060.55016121
76Metabolic pathways_Homo sapiens_hsa011000.53294138
77Protein digestion and absorption_Homo sapiens_hsa049740.50068398
78Other glycan degradation_Homo sapiens_hsa005110.49083035
79Oxidative phosphorylation_Homo sapiens_hsa001900.47777420
80Toxoplasmosis_Homo sapiens_hsa051450.45108720
81Purine metabolism_Homo sapiens_hsa002300.42861688
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41806549
83Huntingtons disease_Homo sapiens_hsa050160.41188707
84Endometrial cancer_Homo sapiens_hsa052130.41050615
85Salivary secretion_Homo sapiens_hsa049700.40987061
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40754456
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38998763
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.38702911
89Glioma_Homo sapiens_hsa052140.38366052
90Pancreatic cancer_Homo sapiens_hsa052120.37885400
91Tyrosine metabolism_Homo sapiens_hsa003500.37087952
92Basal cell carcinoma_Homo sapiens_hsa052170.36649373
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36116478
94Carbon metabolism_Homo sapiens_hsa012000.35601672
95Alcoholism_Homo sapiens_hsa050340.33268477
96Chemical carcinogenesis_Homo sapiens_hsa052040.33257758
97Parkinsons disease_Homo sapiens_hsa050120.31380688
98Glycerolipid metabolism_Homo sapiens_hsa005610.30906874
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29202283
100Selenocompound metabolism_Homo sapiens_hsa004500.28120040

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