ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proteasome assembly (GO:0043248)	5.01133262
2	response to pheromone (GO:0019236)	4.62711490
3	cullin deneddylation (GO:0010388)	3.66611595
4	DNA double-strand break processing (GO:0000729)	3.55088659
5	respiratory chain complex IV assembly (GO:0008535)	3.53705903
6	replication fork processing (GO:0031297)	3.44647010
7	regulation of cilium movement (GO:0003352)	3.43206542
8	protein deneddylation (GO:0000338)	3.39947393
9	microtubule depolymerization (GO:0007019)	3.38774377
10	platelet dense granule organization (GO:0060155)	3.37143911
11	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	3.33695967
12	centriole replication (GO:0007099)	3.30128847
13	protein polyglutamylation (GO:0018095)	3.25240554
14	rRNA modification (GO:0000154)	3.19790865
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.18615056
16	regulation of DNA endoreduplication (GO:0032875)	3.13716754
17	resolution of meiotic recombination intermediates (GO:0000712)	3.13698240
18	protein K6-linked ubiquitination (GO:0085020)	3.12864032
19	piRNA metabolic process (GO:0034587)	3.10600687
20	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.02529964
21	regulation of centriole replication (GO:0046599)	3.00143712
22	cytochrome complex assembly (GO:0017004)	2.99499779
23	intraciliary transport (GO:0042073)	2.96061143
24	rRNA methylation (GO:0031167)	2.95866318
25	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.95132731
26	protein neddylation (GO:0045116)	2.92713037
27	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.90563440
28	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.90563440
29	chromatin remodeling at centromere (GO:0031055)	2.89639832
30	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.88513483
31	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.85450897
32	regulation of cellular amino acid metabolic process (GO:0006521)	2.84937133
33	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.83507901
34	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.81394682
35	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.81394682
36	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.81394682
37	L-fucose catabolic process (GO:0042355)	2.80729661
38	fucose catabolic process (GO:0019317)	2.80729661
39	L-fucose metabolic process (GO:0042354)	2.80729661
40	CENP-A containing nucleosome assembly (GO:0034080)	2.80551409
41	natural killer cell mediated immunity (GO:0002228)	2.80384982
42	natural killer cell mediated cytotoxicity (GO:0042267)	2.80384982
43	DNA catabolic process, exonucleolytic (GO:0000738)	2.78869183
44	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.78675817
45	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.78675817
46	synapsis (GO:0007129)	2.76426750
47	recombinational repair (GO:0000725)	2.76424049
48	acrosome reaction (GO:0007340)	2.75681053
49	histone exchange (GO:0043486)	2.75668474
50	histone H2A acetylation (GO:0043968)	2.74245770
51	organelle disassembly (GO:1903008)	2.73479321
52	tRNA methylation (GO:0030488)	2.73050657
53	mannosylation (GO:0097502)	2.72165723
54	double-strand break repair via homologous recombination (GO:0000724)	2.71400729
55	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.70665027
56	sperm motility (GO:0030317)	2.69881104
57	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.68276043
58	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.67823482
59	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.67823482
60	negative regulation of ligase activity (GO:0051352)	2.66715964
61	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.66715964
62	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.64776449
63	regulation of glucokinase activity (GO:0033131)	2.64455679
64	regulation of hexokinase activity (GO:1903299)	2.64455679
65	ribonucleoprotein complex disassembly (GO:0032988)	2.64392123
66	epithelial cilium movement (GO:0003351)	2.64012965
67	spermatid nucleus differentiation (GO:0007289)	2.63860632
68	cilium morphogenesis (GO:0060271)	2.63363653
69	microtubule polymerization or depolymerization (GO:0031109)	2.63087449
70	protein complex biogenesis (GO:0070271)	2.62370687
71	mitochondrial respiratory chain complex assembly (GO:0033108)	2.61551410
72	behavioral response to nicotine (GO:0035095)	2.58007036
73	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.57891434
74	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.56746737
75	nonmotile primary cilium assembly (GO:0035058)	2.56622990
76	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.56607628
77	termination of RNA polymerase III transcription (GO:0006386)	2.56607628
78	negative regulation of cell cycle G2/M phase transition (GO:1902750)	2.56230971
79	prenylation (GO:0097354)	2.54926285
80	protein prenylation (GO:0018342)	2.54926285
81	protein heterotetramerization (GO:0051290)	2.54691158
82	DNA damage response, detection of DNA damage (GO:0042769)	2.54095716
83	DNA replication checkpoint (GO:0000076)	2.51670949
84	adaptation of signaling pathway (GO:0023058)	2.50953422
85	ketone body metabolic process (GO:1902224)	2.50043871
86	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.48568691
87	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.48505927
88	isotype switching (GO:0045190)	2.48505927
89	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.48505927
90	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.47684978
91	lactate metabolic process (GO:0006089)	2.46255419
92	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.45906355
93	regulation of meiosis I (GO:0060631)	2.45269188
94	peptidyl-histidine modification (GO:0018202)	2.45252809
95	pseudouridine synthesis (GO:0001522)	2.44980277
96	attachment of spindle microtubules to kinetochore (GO:0008608)	2.44567986
97	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.40263668
98	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.39392988
99	male meiosis (GO:0007140)	2.39281149
100	NADH dehydrogenase complex assembly (GO:0010257)	2.39003685

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.13013073
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.47839805
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.44043685
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.18045876
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.14823809
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.98522571
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.78691541
8	ELK1_19687146_ChIP-ChIP_HELA_Human	2.56499854
9	FUS_26573619_Chip-Seq_HEK293_Human	2.53096251
10	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.49790256
11	VDR_22108803_ChIP-Seq_LS180_Human	2.34047331
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.27404916
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.18500772
14	EWS_26573619_Chip-Seq_HEK293_Human	2.17804689
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.11937762
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.10510381
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.02096676
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.01786822
19	E2F7_22180533_ChIP-Seq_HELA_Human	1.99967573
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.95265102
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.92217325
22	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.91030720
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.90626007
24	GBX2_23144817_ChIP-Seq_PC3_Human	1.90006340
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.89885955
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.84768485
27	P300_19829295_ChIP-Seq_ESCs_Human	1.84673615
28	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.82237660
29	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.71849787
30	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.69833996
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.64807320
32	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.60184997
33	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.59747880
34	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.58412190
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.57891793
36	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.55899767
37	IGF1R_20145208_ChIP-Seq_DFB_Human	1.54774778
38	FOXP3_21729870_ChIP-Seq_TREG_Human	1.53298242
39	TAF15_26573619_Chip-Seq_HEK293_Human	1.52065334
40	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.49126260
41	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.46821240
42	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.40322624
43	ER_23166858_ChIP-Seq_MCF-7_Human	1.38515756
44	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.38068084
45	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.37488821
46	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.36985130
47	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.33018166
48	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.32556125
49	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.32083819
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29759867
51	IRF1_19129219_ChIP-ChIP_H3396_Human	1.27815194
52	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.26746711
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.24668499
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23122783
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23122783
56	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.22680075
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.22262193
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.22262193
59	GABP_19822575_ChIP-Seq_HepG2_Human	1.20521047
60	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.19898628
61	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.19143498
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.18945072
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16223159
64	DCP1A_22483619_ChIP-Seq_HELA_Human	1.12035551
65	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.11959884
66	SMAD4_21799915_ChIP-Seq_A2780_Human	1.11597203
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11374707
68	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.09968362
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.08199130
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.08199130
71	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.06974197
72	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06970170
73	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.06334677
74	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06334677
75	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.05325344
76	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.05258127
77	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05113091
78	AR_25329375_ChIP-Seq_VCAP_Human	1.04597134
79	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.04111796
80	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.03514792
81	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.01713529
82	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.01376325
83	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01138297
84	TTF2_22483619_ChIP-Seq_HELA_Human	1.00855380
85	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.99933805
86	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.99660179
87	TCF4_22108803_ChIP-Seq_LS180_Human	0.99451572
88	* STAT3_23295773_ChIP-Seq_U87_Human	0.99256029
89	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.99140385
90	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.98482382
91	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.97428106
92	AR_20517297_ChIP-Seq_VCAP_Human	0.95999753
93	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.93871334
94	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.93313090
95	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.92917993
96	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.92679008
97	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.92557146
98	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.91628413
99	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.91310066
100	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.91137227

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	4.39166728
2	MP0002102_abnormal_ear_morphology	3.75057540
3	MP0008057_abnormal_DNA_replication	3.17096097
4	MP0006072_abnormal_retinal_apoptosis	3.05487934
5	MP0008877_abnormal_DNA_methylation	2.87656021
6	MP0002938_white_spotting	2.70361741
7	MP0009697_abnormal_copulation	2.67262908
8	MP0003136_yellow_coat_color	2.59877323
9	MP0010094_abnormal_chromosome_stability	2.52652560
10	MP0008058_abnormal_DNA_repair	2.46217225
11	MP0005253_abnormal_eye_physiology	2.18644696
12	MP0003693_abnormal_embryo_hatching	2.18309929
13	MP0001529_abnormal_vocalization	2.16695217
14	MP0003195_calcinosis	1.86051125
15	MP0005551_abnormal_eye_electrophysiolog	1.80331252
16	MP0003718_maternal_effect	1.71174955
17	MP0005408_hypopigmentation	1.69942422
18	MP0003950_abnormal_plasma_membrane	1.68858649
19	MP0005075_abnormal_melanosome_morpholog	1.65994383
20	MP0003787_abnormal_imprinting	1.58371166
21	MP0001984_abnormal_olfaction	1.54065064
22	MP0002234_abnormal_pharynx_morphology	1.53650203
23	MP0004133_heterotaxia	1.53469989
24	MP0003880_abnormal_central_pattern	1.53359092
25	MP0002736_abnormal_nociception_after	1.52674369
26	MP0003121_genomic_imprinting	1.52061306
27	MP0005410_abnormal_fertilization	1.51517096
28	MP0003077_abnormal_cell_cycle	1.50247055
29	MP0003937_abnormal_limbs/digits/tail_de	1.49492925
30	MP0005084_abnormal_gallbladder_morpholo	1.43521534
31	MP0002095_abnormal_skin_pigmentation	1.43477373
32	MP0010030_abnormal_orbit_morphology	1.43396862
33	MP0006054_spinal_hemorrhage	1.37406631
34	MP0003122_maternal_imprinting	1.37177374
35	MP0002751_abnormal_autonomic_nervous	1.35010617
36	MP0005377_hearing/vestibular/ear_phenot	1.34136916
37	MP0003878_abnormal_ear_physiology	1.34136916
38	MP0004957_abnormal_blastocyst_morpholog	1.34116137
39	MP0002282_abnormal_trachea_morphology	1.33096796
40	MP0003011_delayed_dark_adaptation	1.33051807
41	MP0001293_anophthalmia	1.32609506
42	MP0008932_abnormal_embryonic_tissue	1.32427066
43	MP0003646_muscle_fatigue	1.29147078
44	MP0001929_abnormal_gametogenesis	1.27458396
45	MP0003186_abnormal_redox_activity	1.27360867
46	MP0005171_absent_coat_pigmentation	1.23070351
47	MP0001485_abnormal_pinna_reflex	1.22733548
48	MP0001324_abnormal_eye_pigmentation	1.18600219
49	MP0003786_premature_aging	1.18568736
50	MP0003283_abnormal_digestive_organ	1.17828900
51	MP0002876_abnormal_thyroid_physiology	1.16784839
52	MP0001764_abnormal_homeostasis	1.15912537
53	MP0005187_abnormal_penis_morphology	1.14642472
54	MP0005391_vision/eye_phenotype	1.13041002
55	MP0000569_abnormal_digit_pigmentation	1.12730136
56	MP0000647_abnormal_sebaceous_gland	1.11483388
57	MP0001968_abnormal_touch/_nociception	1.10694100
58	MP0002090_abnormal_vision	1.10126259
59	MP0006292_abnormal_olfactory_placode	1.10009858
60	MP0002233_abnormal_nose_morphology	1.08731501
61	MP0000516_abnormal_urinary_system	1.08164917
62	MP0005367_renal/urinary_system_phenotyp	1.08164917
63	MP0003698_abnormal_male_reproductive	1.07046097
64	MP0010678_abnormal_skin_adnexa	1.06504566
65	MP0006036_abnormal_mitochondrial_physio	1.04209149
66	MP0002210_abnormal_sex_determination	1.04004576
67	MP0003111_abnormal_nucleus_morphology	0.99281042
68	MP0000653_abnormal_sex_gland	0.97826129
69	MP0002928_abnormal_bile_duct	0.97309057
70	MP0003755_abnormal_palate_morphology	0.94986663
71	MP0002837_dystrophic_cardiac_calcinosis	0.93768911
72	MP0005195_abnormal_posterior_eye	0.92500000
73	MP0008789_abnormal_olfactory_epithelium	0.92056538
74	MP0004924_abnormal_behavior	0.91497991
75	MP0005386_behavior/neurological_phenoty	0.91497991
76	MP0000383_abnormal_hair_follicle	0.90749193
77	MP0001286_abnormal_eye_development	0.90058032
78	MP0008872_abnormal_physiological_respon	0.89673420
79	MP0001145_abnormal_male_reproductive	0.87800093
80	MP0006035_abnormal_mitochondrial_morpho	0.87607847
81	MP0003943_abnormal_hepatobiliary_system	0.86927147
82	MP0008875_abnormal_xenobiotic_pharmacok	0.85061367
83	MP0001905_abnormal_dopamine_level	0.84983863
84	MP0000631_abnormal_neuroendocrine_gland	0.84650923
85	MP0002163_abnormal_gland_morphology	0.81869513
86	MP0003119_abnormal_digestive_system	0.81228119
87	MP0001486_abnormal_startle_reflex	0.80363055
88	MP0002653_abnormal_ependyma_morphology	0.80317482
89	MP0005395_other_phenotype	0.79211548
90	MP0001119_abnormal_female_reproductive	0.78752240
91	MP0009046_muscle_twitch	0.76838819
92	MP0003806_abnormal_nucleotide_metabolis	0.76528021
93	MP0000049_abnormal_middle_ear	0.75617493
94	MP0004142_abnormal_muscle_tone	0.74926195
95	MP0002752_abnormal_somatic_nervous	0.74387376
96	MP0004215_abnormal_myocardial_fiber	0.73016194
97	MP0005174_abnormal_tail_pigmentation	0.70848929
98	MP0000427_abnormal_hair_cycle	0.69911970
99	MP0004147_increased_porphyrin_level	0.69866635
100	MP0010234_abnormal_vibrissa_follicle	0.68401818

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	3.63862162
2	Molar tooth sign on MRI (HP:0002419)	3.63862162
3	Pancreatic cysts (HP:0001737)	3.43682421
4	Pancreatic fibrosis (HP:0100732)	3.37842551
5	Volvulus (HP:0002580)	3.12564927
6	True hermaphroditism (HP:0010459)	3.11841059
7	Acute encephalopathy (HP:0006846)	3.03113721
8	Acute necrotizing encephalopathy (HP:0006965)	3.00123407
9	Medial flaring of the eyebrow (HP:0010747)	2.94934107
10	Chronic hepatic failure (HP:0100626)	2.85776530
11	Abnormality of the labia minora (HP:0012880)	2.85020693
12	Intestinal atresia (HP:0011100)	2.84802051
13	Nephronophthisis (HP:0000090)	2.73749713
14	Progressive macrocephaly (HP:0004481)	2.66075914
15	Abnormal mitochondria in muscle tissue (HP:0008316)	2.57161418
16	Bifid tongue (HP:0010297)	2.56018347
17	Congenital primary aphakia (HP:0007707)	2.54722677
18	Gait imbalance (HP:0002141)	2.45965738
19	Pendular nystagmus (HP:0012043)	2.45123208
20	Mitochondrial inheritance (HP:0001427)	2.44027277
21	Increased CSF lactate (HP:0002490)	2.43695628
22	3-Methylglutaconic aciduria (HP:0003535)	2.43556434
23	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.43542487
24	Abnormality of the ileum (HP:0001549)	2.39041084
25	Nephrogenic diabetes insipidus (HP:0009806)	2.36880826
26	Hypoplasia of the fovea (HP:0007750)	2.34993274
27	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.34993274
28	Abnormality of the renal medulla (HP:0100957)	2.34276409
29	Hepatocellular necrosis (HP:0001404)	2.34219665
30	Genital tract atresia (HP:0001827)	2.32693557
31	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.32656892
32	Meckel diverticulum (HP:0002245)	2.27084706
33	Tubulointerstitial nephritis (HP:0001970)	2.26219632
34	Chromsome breakage (HP:0040012)	2.24735184
35	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.24138396
36	Vaginal atresia (HP:0000148)	2.23779691
37	Cystic liver disease (HP:0006706)	2.21803625
38	Short tibia (HP:0005736)	2.21398986
39	Ectopic kidney (HP:0000086)	2.21285426
40	Hypothermia (HP:0002045)	2.20409421
41	Colon cancer (HP:0003003)	2.19508916
42	Attenuation of retinal blood vessels (HP:0007843)	2.18900100
43	Hepatic necrosis (HP:0002605)	2.16880257
44	Preaxial hand polydactyly (HP:0001177)	2.15635988
45	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.14926186
46	Oligodactyly (hands) (HP:0001180)	2.14625298
47	Median cleft lip (HP:0000161)	2.14505989
48	Abnormal biliary tract physiology (HP:0012439)	2.12142266
49	Bile duct proliferation (HP:0001408)	2.12142266
50	Abnormality of the renal cortex (HP:0011035)	2.11462963
51	Postaxial foot polydactyly (HP:0001830)	2.10366639
52	Sclerocornea (HP:0000647)	2.10346872
53	Anencephaly (HP:0002323)	2.10239684
54	Abnormality of macular pigmentation (HP:0008002)	2.09745649
55	Gastrointestinal atresia (HP:0002589)	2.06409903
56	Anophthalmia (HP:0000528)	2.05579976
57	Birth length less than 3rd percentile (HP:0003561)	2.04923886
58	Duodenal stenosis (HP:0100867)	2.02690833
59	Small intestinal stenosis (HP:0012848)	2.02690833
60	Degeneration of anterior horn cells (HP:0002398)	2.02520932
61	Abnormality of the anterior horn cell (HP:0006802)	2.02520932
62	Hyperglycinemia (HP:0002154)	2.00112711
63	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.99425645
64	Abnormality of the fovea (HP:0000493)	1.96121279
65	Occipital encephalocele (HP:0002085)	1.95871162
66	Abnormal lung lobation (HP:0002101)	1.94816822
67	Abnormality of glycolysis (HP:0004366)	1.94374712
68	Ependymoma (HP:0002888)	1.93533652
69	Abnormality of the duodenum (HP:0002246)	1.92239389
70	Postaxial hand polydactyly (HP:0001162)	1.90730649
71	Stenosis of the external auditory canal (HP:0000402)	1.90439007
72	Optic disc pallor (HP:0000543)	1.88782324
73	Abnormality of the preputium (HP:0100587)	1.88620267
74	Cerebral edema (HP:0002181)	1.87913020
75	Abnormality of chromosome stability (HP:0003220)	1.87656354
76	Sloping forehead (HP:0000340)	1.87606100
77	Congenital stationary night blindness (HP:0007642)	1.86972513
78	Astigmatism (HP:0000483)	1.85154778
79	Neoplasm of the adrenal cortex (HP:0100641)	1.82555049
80	Abnormality of methionine metabolism (HP:0010901)	1.82304452
81	Astrocytoma (HP:0009592)	1.81130480
82	Abnormality of the astrocytes (HP:0100707)	1.81130480
83	Horseshoe kidney (HP:0000085)	1.79782033
84	Supernumerary spleens (HP:0009799)	1.78932749
85	Increased serum lactate (HP:0002151)	1.77159367
86	Increased serum pyruvate (HP:0003542)	1.75807302
87	Poor coordination (HP:0002370)	1.75057501
88	Methylmalonic acidemia (HP:0002912)	1.74042629
89	Facial cleft (HP:0002006)	1.73493749
90	Dandy-Walker malformation (HP:0001305)	1.72269628
91	Aganglionic megacolon (HP:0002251)	1.70244532
92	Small hand (HP:0200055)	1.70106275
93	Multicystic kidney dysplasia (HP:0000003)	1.69678672
94	Oculomotor apraxia (HP:0000657)	1.68170042
95	Renal cortical cysts (HP:0000803)	1.66963841
96	Tubulointerstitial abnormality (HP:0001969)	1.66437197
97	Hypoplastic pelvis (HP:0008839)	1.66420152
98	Thyroiditis (HP:0100646)	1.65783350
99	Tubular atrophy (HP:0000092)	1.65061408
100	Glioma (HP:0009733)	1.64042957

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	2.92299206
2	EIF2AK3	2.80295902
3	INSRR	2.74385884
4	FRK	2.68442486
5	NUAK1	2.45965909
6	BMPR1B	2.31598299
7	MKNK2	2.26162844
8	WEE1	2.19711630
9	VRK2	2.16452171
10	STK16	2.09794660
11	CASK	2.08907766
12	BUB1	2.07881283
13	BRSK2	2.06312022
14	BCR	2.04964959
15	SRPK1	2.02458643
16	PLK2	2.01494933
17	PNCK	2.01172584
18	ZAK	1.99318432
19	WNK3	1.92744262
20	PLK3	1.89869565
21	ERBB3	1.88256799
22	PLK4	1.88208308
23	MST4	1.84071582
24	MAP3K4	1.71809871
25	MAP4K2	1.68479500
26	MKNK1	1.55605177
27	NEK1	1.52056525
28	MAP3K12	1.48086558
29	STK39	1.42952762
30	VRK1	1.42434680
31	TSSK6	1.42039157
32	GRK1	1.36392658
33	WNK4	1.34062516
34	EIF2AK1	1.31837861
35	CSNK1G1	1.30719012
36	CSNK1G3	1.25792115
37	TNIK	1.24919291
38	MAP2K7	1.23508104
39	MAPK13	1.18171388
40	CSNK1G2	1.14562381
41	PLK1	1.13958263
42	PAK3	1.11346708
43	STK38L	1.10302814
44	OXSR1	1.06056086
45	BRSK1	1.05587575
46	EPHA4	1.03948215
47	TIE1	1.03445927
48	CDC7	1.03123275
49	SIK3	1.02514331
50	CSNK1A1L	1.01643253
51	STK3	0.91445663
52	CDK8	0.89710108
53	ATR	0.85677238
54	ACVR1B	0.82869554
55	ADRBK2	0.82210221
56	TGFBR1	0.82081469
57	DYRK2	0.81770451
58	LIMK1	0.80435022
59	PINK1	0.79335858
60	CCNB1	0.77688527
61	TTK	0.76581894
62	MUSK	0.76106797
63	PTK2B	0.73291635
64	MET	0.71806198
65	PRKCG	0.69934696
66	EIF2AK2	0.69171904
67	MST1R	0.68852498
68	PRKCE	0.68505858
69	FER	0.67782489
70	PBK	0.66594454
71	BCKDK	0.64691428
72	AURKB	0.64033369
73	TAF1	0.62988157
74	CHEK2	0.62035326
75	FLT3	0.61054879
76	MAPKAPK5	0.58975541
77	MARK1	0.58526850
78	ATM	0.56417600
79	MINK1	0.56389502
80	STK24	0.54888616
81	LMTK2	0.53923935
82	KDR	0.53237979
83	RPS6KA4	0.45149121
84	PRKCI	0.44953733
85	FGFR2	0.44222726
86	PRKCQ	0.42881459
87	PDK2	0.42412359
88	CSNK2A1	0.40456853
89	BRD4	0.39380908
90	PKN1	0.38288964
91	CHEK1	0.37756292
92	CSNK1A1	0.35279141
93	CSNK1E	0.32256695
94	DYRK3	0.31488067
95	ADRBK1	0.31105325
96	CDK7	0.30963073
97	CSNK2A2	0.30878544
98	FGFR1	0.30051547
99	MAP2K4	0.29128094
100	GRK5	0.28713953

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.90870232
2	Proteasome_Homo sapiens_hsa03050	3.72200657
3	Non-homologous end-joining_Homo sapiens_hsa03450	2.89629968
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.82422271
5	RNA polymerase_Homo sapiens_hsa03020	2.48564617
6	Mismatch repair_Homo sapiens_hsa03430	2.45745714
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.40628505
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.34869423
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.25577183
10	Homologous recombination_Homo sapiens_hsa03440	2.17233078
11	Basal transcription factors_Homo sapiens_hsa03022	2.00653860
12	Parkinsons disease_Homo sapiens_hsa05012	2.00392841
13	DNA replication_Homo sapiens_hsa03030	1.99747868
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.98702076
15	Propanoate metabolism_Homo sapiens_hsa00640	1.84715244
16	RNA transport_Homo sapiens_hsa03013	1.84299930
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.82500043
18	Base excision repair_Homo sapiens_hsa03410	1.78944586
19	Butanoate metabolism_Homo sapiens_hsa00650	1.73672615
20	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.72862351
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.67949867
22	Steroid biosynthesis_Homo sapiens_hsa00100	1.67756102
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.65175414
24	RNA degradation_Homo sapiens_hsa03018	1.62113936
25	Huntingtons disease_Homo sapiens_hsa05016	1.60406097
26	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.53544859
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.48944952
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.43136083
29	Fatty acid elongation_Homo sapiens_hsa00062	1.40755805
30	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.38545381
31	Spliceosome_Homo sapiens_hsa03040	1.37890082
32	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.36657608
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.36235188
34	One carbon pool by folate_Homo sapiens_hsa00670	1.34787674
35	Pyrimidine metabolism_Homo sapiens_hsa00240	1.30340818
36	Folate biosynthesis_Homo sapiens_hsa00790	1.27214595
37	Cell cycle_Homo sapiens_hsa04110	1.22136039
38	Phototransduction_Homo sapiens_hsa04744	1.20375070
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.15261621
40	Glutathione metabolism_Homo sapiens_hsa00480	1.13863023
41	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.13517359
42	Alzheimers disease_Homo sapiens_hsa05010	1.09201939
43	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.07572218
44	Nitrogen metabolism_Homo sapiens_hsa00910	1.06292181
45	Purine metabolism_Homo sapiens_hsa00230	0.99977993
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.99342742
47	Caffeine metabolism_Homo sapiens_hsa00232	0.96457338
48	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.91106372
49	Oocyte meiosis_Homo sapiens_hsa04114	0.87797335
50	Peroxisome_Homo sapiens_hsa04146	0.87034325
51	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.83977332
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.82289047
53	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.81436894
54	Pyruvate metabolism_Homo sapiens_hsa00620	0.80721197
55	Metabolic pathways_Homo sapiens_hsa01100	0.80099894
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.75784168
57	Sulfur relay system_Homo sapiens_hsa04122	0.75190080
58	Arginine and proline metabolism_Homo sapiens_hsa00330	0.74114557
59	Sulfur metabolism_Homo sapiens_hsa00920	0.73939549
60	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.73549411
61	Fatty acid metabolism_Homo sapiens_hsa01212	0.72878027
62	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.70745924
63	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68233773
64	Ribosome_Homo sapiens_hsa03010	0.68199101
65	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.66670332
66	Hippo signaling pathway_Homo sapiens_hsa04390	0.58023354
67	p53 signaling pathway_Homo sapiens_hsa04115	0.57297951
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.57204721
69	Nicotine addiction_Homo sapiens_hsa05033	0.56798878
70	Fatty acid degradation_Homo sapiens_hsa00071	0.55910695
71	Regulation of autophagy_Homo sapiens_hsa04140	0.55566849
72	mRNA surveillance pathway_Homo sapiens_hsa03015	0.55071116
73	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.54182492
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.52589387
75	Linoleic acid metabolism_Homo sapiens_hsa00591	0.51583308
76	Retinol metabolism_Homo sapiens_hsa00830	0.50800696
77	Taste transduction_Homo sapiens_hsa04742	0.49518414
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49266489
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48764806
80	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.48328628
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.48316287
82	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.48162729
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.47549700
84	Olfactory transduction_Homo sapiens_hsa04740	0.46451883
85	Carbon metabolism_Homo sapiens_hsa01200	0.45408811
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.44428940
87	Tyrosine metabolism_Homo sapiens_hsa00350	0.43650368
88	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.43258706
89	Basal cell carcinoma_Homo sapiens_hsa05217	0.42526967
90	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.41811344
91	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41684932
92	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.41631124
93	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.39383779
94	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.39067893
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38815355
96	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.37696311
97	beta-Alanine metabolism_Homo sapiens_hsa00410	0.36896628
98	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.35755442
99	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.34099270
100	Circadian rhythm_Homo sapiens_hsa04710	0.29223917

RAET1K

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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