RAET1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RAET1L belongs to the RAET1 family of major histocompatibility complex (MHC) class I-related genes, which are located within a 180-kb cluster on chromosome 6q24.2-q25.3. The REAT1 genes encode glycoproteins that contain extracellular alpha-1 and alpha-2 domains, but they lack the membrane proximal Ig-like alpha-3 domain. Most RAET1 glycoproteins are anchored to the membrane via glycosylphosphatidylinositol (GPI) linkage (Radosavljevic et al., 2002 [PubMed 11827464]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)9.88025655
2regulation of water loss via skin (GO:0033561)8.82691339
3keratinocyte proliferation (GO:0043616)7.66911514
4bundle of His cell to Purkinje myocyte communication (GO:0086069)7.47470700
5keratinocyte differentiation (GO:0030216)7.47421424
6epidermal cell differentiation (GO:0009913)6.18764767
7natural killer cell mediated immunity (GO:0002228)5.98758051
8natural killer cell mediated cytotoxicity (GO:0042267)5.98758051
9peptide cross-linking (GO:0018149)5.76878843
10multicellular organismal water homeostasis (GO:0050891)5.61519246
11negative regulation of keratinocyte proliferation (GO:0010839)5.56610649
12molting cycle (GO:0042303)5.44913641
13hair cycle (GO:0042633)5.44913641
14epidermis development (GO:0008544)5.17164624
15intestinal epithelial cell development (GO:0060576)5.14832991
16keratinocyte development (GO:0003334)5.09578141
17negative regulation of complement activation (GO:0045916)4.81236038
18positive regulation of epidermal cell differentiation (GO:0045606)4.78501057
19positive regulation of epidermis development (GO:0045684)4.78250176
20positive regulation of p38MAPK cascade (GO:1900745)4.74977679
21water homeostasis (GO:0030104)4.66614034
22ectoderm development (GO:0007398)4.30703770
23intermediate filament organization (GO:0045109)4.23028724
24negative regulation of protein activation cascade (GO:2000258)4.22313201
25regulation of keratinocyte proliferation (GO:0010837)3.96774678
26skin morphogenesis (GO:0043589)3.86675984
27cell-substrate junction assembly (GO:0007044)3.79516555
28regulation of transforming growth factor beta2 production (GO:0032909)3.78374234
29cytokine production involved in immune response (GO:0002367)3.71846100
30regulation of epidermis development (GO:0045682)3.67915768
31gap junction assembly (GO:0016264)3.60629691
32positive regulation of keratinocyte differentiation (GO:0045618)3.58177016
33cell adhesion mediated by integrin (GO:0033627)3.50626831
34negative regulation of humoral immune response (GO:0002921)3.48528079
35hypotonic response (GO:0006971)3.45614980
36chemical homeostasis within a tissue (GO:0048875)3.40399754
37regulation of keratinocyte differentiation (GO:0045616)3.39964913
38regulation of p38MAPK cascade (GO:1900744)3.36201665
39ribosome assembly (GO:0042255)3.35420844
40mammary gland epithelial cell proliferation (GO:0033598)3.29793108
41regulation of transforming growth factor beta1 production (GO:0032908)3.28592548
42COPI coating of Golgi vesicle (GO:0048205)3.27136011
43Golgi transport vesicle coating (GO:0048200)3.27136011
44cellular copper ion homeostasis (GO:0006878)3.24256372
45regulation of epidermal cell differentiation (GO:0045604)3.22792634
46ribosomal small subunit biogenesis (GO:0042274)3.15714657
47activation of MAPKKK activity (GO:0000185)3.10325373
48ER overload response (GO:0006983)3.07900600
49protein localization to microtubule (GO:0035372)3.06557327
50membrane budding (GO:0006900)3.05060603
51surfactant homeostasis (GO:0043129)3.01854116
52establishment of tissue polarity (GO:0007164)3.01707680
53establishment of planar polarity (GO:0001736)3.01707680
54linoleic acid metabolic process (GO:0043651)2.98990714
55transcription elongation from RNA polymerase I promoter (GO:0006362)2.94758932
56positive regulation of hair cycle (GO:0042635)2.94638376
57positive regulation of hair follicle development (GO:0051798)2.94638376
58intermediate filament cytoskeleton organization (GO:0045104)2.94415065
59positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.93764794
60regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.93764794
61ribosomal large subunit biogenesis (GO:0042273)2.92810198
62mitotic G1/S transition checkpoint (GO:0044819)2.87937236
63intermediate filament-based process (GO:0045103)2.85674919
64negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.82939159
65rRNA methylation (GO:0031167)2.77553625
66dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.77223435
67leukocyte mediated cytotoxicity (GO:0001909)2.75538876
68regulation of hair follicle development (GO:0051797)2.72395400
69regulation of hair cycle (GO:0042634)2.70760313
70mitotic G1 DNA damage checkpoint (GO:0031571)2.70289093
71transcription initiation from RNA polymerase I promoter (GO:0006361)2.70089884
72positive regulation of transforming growth factor beta production (GO:0071636)2.66458821
73regulation of metalloenzyme activity (GO:0048552)2.65962555
74termination of RNA polymerase I transcription (GO:0006363)2.65823829
75negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.65014273
76exogenous drug catabolic process (GO:0042738)2.64577987
77membrane raft organization (GO:0031579)2.63690175
78hair follicle morphogenesis (GO:0031069)2.60966293
79fusion of sperm to egg plasma membrane (GO:0007342)2.60638772
80negative regulation of chondrocyte differentiation (GO:0032331)2.60427654
81mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.58439728
82regulation of translational termination (GO:0006449)2.55286879
83regulation of transforming growth factor beta production (GO:0071634)2.54486893
84polarized epithelial cell differentiation (GO:0030859)2.53752043
85glomerular visceral epithelial cell development (GO:0072015)2.53401561
86establishment of apical/basal cell polarity (GO:0035089)2.52530780
87regulation of cell proliferation involved in kidney development (GO:1901722)2.47485336
88positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.47476324
89copper ion homeostasis (GO:0055070)2.46948202
90lipoxygenase pathway (GO:0019372)2.45807089
91negative regulation of response to reactive oxygen species (GO:1901032)2.43860802
92long-chain fatty acid biosynthetic process (GO:0042759)2.41768581
93epithelium development (GO:0060429)2.40408011
94ribonucleoprotein complex biogenesis (GO:0022613)2.38191011
95G1 DNA damage checkpoint (GO:0044783)2.37424546
96negative regulation of stem cell proliferation (GO:2000647)2.36710657
97regulation of hydrogen peroxide-induced cell death (GO:1903205)2.36388755
98keratinization (GO:0031424)12.7213583
99hemidesmosome assembly (GO:0031581)10.7750159
100desmosome organization (GO:0002934)10.4176703

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.95572874
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human5.55385486
3SMAD3_18955504_ChIP-ChIP_HaCaT_Human3.62155346
4SMAD2_18955504_ChIP-ChIP_HaCaT_Human3.62155346
5P63_26484246_Chip-Seq_KERATINOCYTES_Human2.99275068
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.32131668
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.16649646
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.13447917
9HIF1A_21447827_ChIP-Seq_MCF-7_Human2.07914612
10FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human2.04112576
11ATF3_27146783_Chip-Seq_COLON_Human2.00516540
12TP63_17297297_ChIP-ChIP_HaCaT_Human13.3133749
13ZNF263_19887448_ChIP-Seq_K562_Human1.96307242
14DCP1A_22483619_ChIP-Seq_HELA_Human1.91123762
15GABP_17652178_ChIP-ChIP_JURKAT_Human1.88810556
16ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.85842009
17SOX9_24532713_ChIP-Seq_HFSC_Mouse1.83838747
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81282862
19KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75876878
20FOXO3_23340844_ChIP-Seq_DLD1_Human1.75387414
21KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.72922200
22ELK1_22589737_ChIP-Seq_MCF10A_Human1.72135358
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71881577
24GATA4_25053715_ChIP-Seq_YYC3_Human1.70707371
25JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69683242
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68515581
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.66490795
28TP63_23658742_ChIP-Seq_EP156T_Human1.65797698
29SOX2_20726797_ChIP-Seq_SW620_Human1.62017868
30SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.60418499
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.57299109
32TP53_18474530_ChIP-ChIP_U2OS_Human1.56255489
33CJUN_26792858_Chip-Seq_BT549_Human1.56173529
34JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55986408
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.54389700
36AR_21909140_ChIP-Seq_LNCAP_Human1.47964971
37ELK1_19687146_ChIP-ChIP_HELA_Human1.46919346
38* GATA3_24758297_ChIP-Seq_MCF-7_Human1.42101502
39UBF1/2_26484160_Chip-Seq_HMECs_Human1.40677479
40CDX2_20551321_ChIP-Seq_CACO-2_Human1.40006801
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.38384819
42KLF5_25053715_ChIP-Seq_YYC3_Human1.36261882
43ELF5_23300383_ChIP-Seq_T47D_Human1.34894691
44GATA6_25053715_ChIP-Seq_YYC3_Human1.34072266
45ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30770013
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.28900680
47HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.26943153
48PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.24626580
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.24495331
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.23204908
51EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20578265
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19880481
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18249146
54XRN2_22483619_ChIP-Seq_HELA_Human1.15193738
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13078941
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12332737
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.12026146
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10947502
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.09318585
60ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08735791
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04762149
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04640443
63RUNX1_27514584_Chip-Seq_MCF-7_Human1.04404046
64TP63_22573176_ChIP-Seq_HFKS_Human1.02685525
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01744118
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01480891
67FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98003272
68KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96429119
69STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92155197
70NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89620545
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89620545
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89114498
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88257119
74EGR1_23403033_ChIP-Seq_LIVER_Mouse0.87794818
75CHD1_26751641_Chip-Seq_LNCaP_Human0.87537511
76CLOCK_20551151_ChIP-Seq_293T_Human0.87104648
77BRD4_25478319_ChIP-Seq_HGPS_Human0.86103900
78ETS1_20019798_ChIP-Seq_JURKAT_Human0.85169194
79MYC_19030024_ChIP-ChIP_MESCs_Mouse0.84384382
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84167231
81E2F1_18555785_ChIP-Seq_MESCs_Mouse0.83058954
82FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82330206
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82025434
84FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.81879948
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80739382
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77993125
87TFEB_21752829_ChIP-Seq_HELA_Human0.76419145
88CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.75726920
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.75030149
90AHR_22903824_ChIP-Seq_MCF-7_Human0.73181782
91TP53_22127205_ChIP-Seq_IMR90_Human0.70974956
92EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.70526693
93UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.70479725
94STAT3_1855785_ChIP-Seq_MESCs_Mouse0.70202800
95ERG_20517297_ChIP-Seq_VCAP_Human0.69849376
96P300_27058665_Chip-Seq_ZR-75-30cells_Human0.69295761
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.68780782
98TTF2_22483619_ChIP-Seq_HELA_Human0.68496370
99GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.67465305
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.66384362

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle7.89000326
2MP0000579_abnormal_nail_morphology6.31535920
3MP0002796_impaired_skin_barrier6.25994080
4MP0005501_abnormal_skin_physiology4.11602073
5MP0010678_abnormal_skin_adnexa3.42346916
6MP0005275_abnormal_skin_tensile3.40816014
7MP0000762_abnormal_tongue_morphology3.30484181
8MP0000467_abnormal_esophagus_morphology3.20182525
9MP0001216_abnormal_epidermal_layer3.05914014
10MP0002098_abnormal_vibrissa_morphology3.02273861
11MP0003453_abnormal_keratinocyte_physiol2.85223680
12MP0003941_abnormal_skin_development2.75999413
13MP0009780_abnormal_chondrocyte_physiolo2.67169858
14MP0002060_abnormal_skin_morphology2.54264692
15MP0010771_integument_phenotype2.50406130
16MP0009053_abnormal_anal_canal2.38789043
17MP0000383_abnormal_hair_follicle2.34173363
18MP0000566_synostosis2.29408136
19MP0004264_abnormal_extraembryonic_tissu2.15637471
20MP0003566_abnormal_cell_adhesion2.07028767
21MP0000377_abnormal_hair_follicle1.97698301
22MP0004782_abnormal_surfactant_physiolog1.88307949
23MP0002234_abnormal_pharynx_morphology1.86654981
24MP0004381_abnormal_hair_follicle1.83006088
25MP0003950_abnormal_plasma_membrane1.81735444
26MP0003705_abnormal_hypodermis_morpholog1.61796318
27MP0000678_abnormal_parathyroid_gland1.58661712
28MP0004272_abnormal_basement_membrane1.52365346
29MP0005409_darkened_coat_color1.50940939
30MP0005023_abnormal_wound_healing1.49063672
31MP0003315_abnormal_perineum_morphology1.47447460
32MP0008875_abnormal_xenobiotic_pharmacok1.40064083
33MP0009931_abnormal_skin_appearance1.32723330
34MP0005360_urolithiasis1.30722018
35MP0004947_skin_inflammation1.28449280
36MP0000427_abnormal_hair_cycle1.28126915
37MP0010352_gastrointestinal_tract_polyps1.27812113
38MP0008260_abnormal_autophagy1.26132215
39MP0000647_abnormal_sebaceous_gland1.25305252
40MP0004957_abnormal_blastocyst_morpholog1.23259642
41MP0003191_abnormal_cellular_cholesterol1.22403578
42MP0009697_abnormal_copulation1.15577134
43MP0000627_abnormal_mammary_gland1.13072988
44MP0000367_abnormal_coat/_hair1.12473723
45MP0000537_abnormal_urethra_morphology1.10694983
46MP0001191_abnormal_skin_condition1.10497769
47MP0004885_abnormal_endolymph1.07566997
48MP0004185_abnormal_adipocyte_glucose1.05776383
49MP0003755_abnormal_palate_morphology1.01365199
50MP0004043_abnormal_pH_regulation0.94741836
51MP0001851_eye_inflammation0.91252697
52MP0010030_abnormal_orbit_morphology0.87040699
53MP0005410_abnormal_fertilization0.86308206
54MP0003718_maternal_effect0.81867301
55MP0001881_abnormal_mammary_gland0.78613093
56MP0005257_abnormal_intraocular_pressure0.75663448
57MP0002282_abnormal_trachea_morphology0.66934157
58MP0005408_hypopigmentation0.66585596
59MP0002233_abnormal_nose_morphology0.66148221
60MP0000470_abnormal_stomach_morphology0.66134860
61MP0003693_abnormal_embryo_hatching0.64523456
62MP0005165_increased_susceptibility_to0.63467681
63MP0003186_abnormal_redox_activity0.63302867
64MP0001340_abnormal_eyelid_morphology0.62534363
65MP0001299_abnormal_eye_distance/0.61625105
66MP0002111_abnormal_tail_morphology0.60995438
67MP0003806_abnormal_nucleotide_metabolis0.60417206
68MP0002136_abnormal_kidney_physiology0.60270297
69MP0000858_altered_metastatic_potential0.58820124
70MP0001243_abnormal_dermal_layer0.58620615
71MP0009643_abnormal_urine_homeostasis0.53527447
72MP0010368_abnormal_lymphatic_system0.53145930
73MP0005187_abnormal_penis_morphology0.50050726
74MP0002877_abnormal_melanocyte_morpholog0.49766278
75MP0003638_abnormal_response/metabolism_0.44456667
76MP0002132_abnormal_respiratory_system0.43082044
77MP0005451_abnormal_body_composition0.41965773
78MP0008932_abnormal_embryonic_tissue0.40880545
79MP0002697_abnormal_eye_size0.40460430
80MP0001849_ear_inflammation0.40221983
81MP0001784_abnormal_fluid_regulation0.39347718
82MP0005193_abnormal_anterior_eye0.38208069
83MP0009379_abnormal_foot_pigmentation0.38025317
84MP0003937_abnormal_limbs/digits/tail_de0.37755851
85MP0002177_abnormal_outer_ear0.37382782
86MP0009250_abnormal_appendicular_skeleto0.36989956
87MP0003252_abnormal_bile_duct0.36135213
88MP0000432_abnormal_head_morphology0.36008715
89MP0002089_abnormal_postnatal_growth/wei0.35672456
90MP0000613_abnormal_salivary_gland0.35576570
91MP0002896_abnormal_bone_mineralization0.33505496
92MP0005164_abnormal_response_to0.33071954
93MP0002086_abnormal_extraembryonic_tissu0.32778421
94MP0002095_abnormal_skin_pigmentation0.32666889
95MP0005375_adipose_tissue_phenotype0.31942159
96MP0003786_premature_aging0.31444914
97MP0000003_abnormal_adipose_tissue0.31118204
98MP0002092_abnormal_eye_morphology0.31113637
99MP0003936_abnormal_reproductive_system0.30237204
100MP0005666_abnormal_adipose_tissue0.30162357

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)9.25536323
2Plantar hyperkeratosis (HP:0007556)7.35555817
3Oral leukoplakia (HP:0002745)7.28876318
4Palmoplantar hyperkeratosis (HP:0000972)6.80557245
5Onycholysis (HP:0001806)6.61580196
6Fragile nails (HP:0001808)6.51337317
7Palmar hyperkeratosis (HP:0010765)6.46322892
8Thick nail (HP:0001805)6.23104250
9Milia (HP:0001056)5.99931428
10Congenital ichthyosiform erythroderma (HP:0007431)5.96853055
11Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.45223720
12Alopecia of scalp (HP:0002293)5.42452692
13Right ventricular cardiomyopathy (HP:0011663)5.10437737
14Nail dystrophy (HP:0008404)4.78950927
15Parakeratosis (HP:0001036)4.57242298
16Hypotrichosis (HP:0001006)4.57223940
17Erythroderma (HP:0001019)4.43365695
18Sparse eyelashes (HP:0000653)4.39464634
19Lip pit (HP:0100267)4.36499311
20Amniotic constriction ring (HP:0009775)4.33072637
21Abnormality of placental membranes (HP:0011409)4.33072637
22Atrophic scars (HP:0001075)4.00708742
23Pili torti (HP:0003777)3.97872274
24Ridged nail (HP:0001807)3.87698177
25Erythema (HP:0010783)3.86441201
26Woolly hair (HP:0002224)3.70519406
27Abnormal blistering of the skin (HP:0008066)3.59077267
28Sparse scalp hair (HP:0002209)3.57377719
29Oligodontia (HP:0000677)3.41464306
30Ectropion (HP:0000656)3.31304667
31Palmoplantar keratoderma (HP:0000982)3.28907014
32Corneal erosion (HP:0200020)3.24185237
33Increased IgE level (HP:0003212)3.23886540
34Popliteal pterygium (HP:0009756)3.15502517
35Abnormal hair laboratory examination (HP:0003328)3.11396242
36Aplasia cutis congenita (HP:0001057)3.08721731
37Follicular hyperkeratosis (HP:0007502)2.89967088
38Pterygium (HP:0001059)2.78176970
39Hypohidrosis (HP:0000966)2.77317116
40Abnormality of the axillary hair (HP:0100134)2.72824277
41Abnormality of secondary sexual hair (HP:0009888)2.72824277
42Pustule (HP:0200039)2.71841231
43Natal tooth (HP:0000695)2.62236867
44Absent eyelashes (HP:0000561)2.57972253
45Hyperhidrosis (HP:0000975)2.55368885
46Hypoplasia of dental enamel (HP:0006297)2.51802785
47Dehydration (HP:0001944)2.44281871
48Brittle hair (HP:0002299)2.40200961
49Abnormality of the salivary glands (HP:0010286)2.33912923
50Selective tooth agenesis (HP:0001592)2.32467650
51Absent hair (HP:0002298)2.25690152
52Fragile skin (HP:0001030)2.24281436
53Carious teeth (HP:0000670)2.16477857
54Anonychia (HP:0001798)2.16113653
55Ankyloglossia (HP:0010296)2.11234427
56Hoarse voice (HP:0001609)2.04879276
57Advanced eruption of teeth (HP:0006288)2.02068650
58Dry hair (HP:0011359)2.01936217
59Abnormality of the gastric mucosa (HP:0004295)2.01763430
60Acanthosis nigricans (HP:0000956)2.00491851
61Trismus (HP:0000211)1.99388004
62Blepharitis (HP:0000498)1.89936685
63Laryngomalacia (HP:0001601)1.88518293
64Furrowed tongue (HP:0000221)1.83714007
65Fatigable weakness (HP:0003473)1.83302049
66Abnormality of the neuromuscular junction (HP:0003398)1.83302049
67Amelogenesis imperfecta (HP:0000705)1.80364678
68Abnormality of the fingernails (HP:0001231)1.79508590
69Palpitations (HP:0001962)1.77091843
70Abnormalities of placenta or umbilical cord (HP:0001194)1.76857225
71Hypodontia (HP:0000668)1.75854166
72Hypoplastic labia majora (HP:0000059)1.72128421
73Malnutrition (HP:0004395)1.70570962
74Pruritus (HP:0000989)1.70009703
75Subacute progressive viral hepatitis (HP:0006572)1.68380690
76Dry skin (HP:0000958)1.62785561
77Increased connective tissue (HP:0009025)1.62200847
78Septate vagina (HP:0001153)1.61686691
79Corneal dystrophy (HP:0001131)1.61008618
80Confusion (HP:0001289)1.60380825
81Xerostomia (HP:0000217)1.58744729
82Abnormality of the distal phalanges of the toes (HP:0010182)1.57939591
83Abnormality of oral frenula (HP:0000190)1.57681964
84Conjunctival hamartoma (HP:0100780)1.56566028
85Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.55922847
86Conical tooth (HP:0000698)1.55817295
87Squamous cell carcinoma (HP:0002860)1.54239921
88Short chin (HP:0000331)1.49085865
89Hypoplasia of the uterus (HP:0000013)1.48834729
90Villous atrophy (HP:0011473)1.48366620
91Abnormality of small intestinal villus morphology (HP:0011472)1.48366620
92Abnormality of the labia majora (HP:0012881)1.47710267
93Micronodular cirrhosis (HP:0001413)1.46039974
94Multifactorial inheritance (HP:0001426)1.45963457
95Hypoplastic toenails (HP:0001800)1.45504716
96Poikiloderma (HP:0001029)1.42452839
97Distal lower limb muscle weakness (HP:0009053)1.42190670
98Macrocytic anemia (HP:0001972)1.42055930
99Conjugated hyperbilirubinemia (HP:0002908)1.41362192
100Abnormality of monocarboxylic acid metabolism (HP:0010996)1.40451897

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.74694504
2MST1R5.27768276
3MST44.58945209
4MAP3K124.15046910
5LATS22.78150565
6MAP3K92.71802146
7EIF2AK12.40163510
8EIF2AK32.30095065
9MET2.24686654
10ARAF2.14948257
11EPHB22.11701332
12RPS6KB22.07067822
13STK241.94544687
14IRAK31.84585467
15MAP3K31.73469569
16LATS11.68317658
17IRAK21.60512357
18PBK1.49871672
19PAK41.42137637
20MAP4K21.41265099
21MAP3K21.31567104
22STK161.31221693
23SRPK11.28725786
24IRAK11.26375747
25STK38L1.25124145
26LMTK21.24502447
27CDK121.20772747
28ERBB31.18705350
29MYLK1.14224648
30RIPK11.05935769
31PIM21.04981334
32STK391.02840926
33FER1.02250167
34PTK20.99861968
35NME20.98230007
36MAPKAPK30.97756114
37TESK20.95980342
38ABL20.95902544
39CDK80.94234246
40TGFBR10.84810722
41TESK10.81213966
42AKT30.80497780
43MAP3K130.79477080
44YES10.73116931
45STK30.72765819
46NEK60.71654110
47STK380.71316613
48SIK10.71000572
49EIF2AK20.69278560
50NME10.68859694
51STK100.63757817
52SCYL20.63466119
53BRAF0.63394352
54ILK0.62774994
55PRKCI0.60731863
56MOS0.60446723
57OXSR10.58277610
58PHKG20.55572378
59PHKG10.55572378
60TRPM70.54825959
61VRK10.53740382
62ERBB40.53601062
63BCR0.51469733
64WNK40.49816476
65BUB10.49013366
66TSSK60.48151331
67CDK90.47734986
68ROCK10.43748450
69AURKA0.43486463
70AURKB0.42945903
71MAP3K10.42104855
72NTRK10.40561605
73ADRBK10.40196568
74MAP3K60.39846528
75TAOK20.33987626
76RPS6KA40.33886811
77RPS6KB10.33815274
78MUSK0.33776619
79ROCK20.33498400
80DAPK10.32913319
81KSR10.32904646
82DYRK30.30650580
83CDK70.30024710
84PRKG20.29828134
85MAP2K70.29701041
86KSR20.27933155
87BRD40.27882072
88PAK20.27253164
89GSK3A0.25511953
90MAP3K80.24660015
91PDK20.24067257
92IKBKB0.23862755
93CSNK2A20.22443622
94CHUK0.21861648
95TAOK10.20186832
96WNK10.18416661
97AKT20.17654974
98CHEK10.15905843
99MAP2K10.15666977
100IGF1R0.15022866

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.58614738
2Proteasome_Homo sapiens_hsa030503.03659855
3Ribosome_Homo sapiens_hsa030103.02769577
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.80224955
5Basal transcription factors_Homo sapiens_hsa030222.77451598
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.39645143
7Retinol metabolism_Homo sapiens_hsa008302.22727294
8Steroid hormone biosynthesis_Homo sapiens_hsa001402.16640885
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.13536832
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.13183919
11Drug metabolism - other enzymes_Homo sapiens_hsa009832.13178441
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.98694010
13Chemical carcinogenesis_Homo sapiens_hsa052041.98367806
14Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.91454158
15ECM-receptor interaction_Homo sapiens_hsa045121.81294077
16Nucleotide excision repair_Homo sapiens_hsa034201.76207915
17Linoleic acid metabolism_Homo sapiens_hsa005911.74005343
18Sulfur metabolism_Homo sapiens_hsa009201.72595442
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.71527033
20Phenylalanine metabolism_Homo sapiens_hsa003601.68223375
21p53 signaling pathway_Homo sapiens_hsa041151.67815346
22Oxidative phosphorylation_Homo sapiens_hsa001901.67194997
23Sphingolipid metabolism_Homo sapiens_hsa006001.40140125
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39544124
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36744574
26Steroid biosynthesis_Homo sapiens_hsa001001.35541235
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32552999
28Adherens junction_Homo sapiens_hsa045201.30379948
29Starch and sucrose metabolism_Homo sapiens_hsa005001.26553382
30Arginine biosynthesis_Homo sapiens_hsa002201.22779593
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.22404118
32Fatty acid elongation_Homo sapiens_hsa000621.20657681
33Hippo signaling pathway_Homo sapiens_hsa043901.18081145
34Tryptophan metabolism_Homo sapiens_hsa003801.11238951
35Huntingtons disease_Homo sapiens_hsa050161.05890247
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04005816
37Protein export_Homo sapiens_hsa030601.02603602
38Tight junction_Homo sapiens_hsa045300.98823258
39Arginine and proline metabolism_Homo sapiens_hsa003300.98443281
40RNA transport_Homo sapiens_hsa030130.97219394
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96526081
42Alzheimers disease_Homo sapiens_hsa050100.96415174
43RNA polymerase_Homo sapiens_hsa030200.95802704
44Parkinsons disease_Homo sapiens_hsa050120.93200592
45Arachidonic acid metabolism_Homo sapiens_hsa005900.92114881
46Tyrosine metabolism_Homo sapiens_hsa003500.90785615
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88522855
48Circadian rhythm_Homo sapiens_hsa047100.85226994
49Vibrio cholerae infection_Homo sapiens_hsa051100.83050671
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82108656
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81683173
52Thyroid cancer_Homo sapiens_hsa052160.81669957
53Small cell lung cancer_Homo sapiens_hsa052220.78026581
54Bladder cancer_Homo sapiens_hsa052190.75813176
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74618928
56Histidine metabolism_Homo sapiens_hsa003400.73008229
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72875108
58Mineral absorption_Homo sapiens_hsa049780.72819239
59Regulation of autophagy_Homo sapiens_hsa041400.71652861
60Fatty acid degradation_Homo sapiens_hsa000710.71494220
61Non-homologous end-joining_Homo sapiens_hsa034500.70447992
62Bile secretion_Homo sapiens_hsa049760.68698827
63Collecting duct acid secretion_Homo sapiens_hsa049660.67557026
64One carbon pool by folate_Homo sapiens_hsa006700.65319947
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54858123
66Focal adhesion_Homo sapiens_hsa045100.54313796
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53949112
68Renal cell carcinoma_Homo sapiens_hsa052110.52909602
69N-Glycan biosynthesis_Homo sapiens_hsa005100.52832736
70Glutathione metabolism_Homo sapiens_hsa004800.51010838
71beta-Alanine metabolism_Homo sapiens_hsa004100.50231482
72Basal cell carcinoma_Homo sapiens_hsa052170.50038970
73Metabolic pathways_Homo sapiens_hsa011000.48617249
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.47433368
75mRNA surveillance pathway_Homo sapiens_hsa030150.47180865
76Amoebiasis_Homo sapiens_hsa051460.46955722
77TGF-beta signaling pathway_Homo sapiens_hsa043500.46337070
78ErbB signaling pathway_Homo sapiens_hsa040120.45475461
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44645152
80Proteoglycans in cancer_Homo sapiens_hsa052050.42949548
81Pentose phosphate pathway_Homo sapiens_hsa000300.40957178
82Cell cycle_Homo sapiens_hsa041100.40352692
83Hepatitis C_Homo sapiens_hsa051600.40212396
84Apoptosis_Homo sapiens_hsa042100.39315231
85Protein digestion and absorption_Homo sapiens_hsa049740.38170056
86Folate biosynthesis_Homo sapiens_hsa007900.36526586
87Complement and coagulation cascades_Homo sapiens_hsa046100.35847491
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35715683
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.35657204
90Axon guidance_Homo sapiens_hsa043600.33960239
91Ether lipid metabolism_Homo sapiens_hsa005650.30914089
92Shigellosis_Homo sapiens_hsa051310.30502025
93Dorso-ventral axis formation_Homo sapiens_hsa043200.30389614
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29436809
95Fatty acid metabolism_Homo sapiens_hsa012120.28925122
96Endocytosis_Homo sapiens_hsa041440.28513678
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27765602
98Notch signaling pathway_Homo sapiens_hsa043300.27710166
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24615258
100Spliceosome_Homo sapiens_hsa030400.22883354

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »