RAG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)9.50732906
2regulation of gamma-delta T cell activation (GO:0046643)9.29634490
3activated T cell proliferation (GO:0050798)8.82614092
4positive T cell selection (GO:0043368)8.79081561
5response to hydroperoxide (GO:0033194)7.93502894
6T cell selection (GO:0045058)7.89179361
7resolution of meiotic recombination intermediates (GO:0000712)7.75430509
8negative T cell selection (GO:0043383)7.21010622
9Peyers patch development (GO:0048541)7.15605460
10mucosal-associated lymphoid tissue development (GO:0048537)7.15605460
11positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.46899801
12genitalia morphogenesis (GO:0035112)6.27714751
13modulation by virus of host process (GO:0019054)5.89170849
14cellular hyperosmotic response (GO:0071474)5.76450084
15* somatic cell DNA recombination (GO:0016444)5.74415241
16* somatic diversification of immune receptors via germline recombination within a single locus (GO:0005.74415241
17T cell receptor signaling pathway (GO:0050852)5.71438760
18alpha-beta T cell differentiation (GO:0046632)5.69672163
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.61309961
20positive regulation of calcium-mediated signaling (GO:0050850)5.52427023
21labyrinthine layer development (GO:0060711)5.41659355
22alpha-beta T cell activation (GO:0046631)5.31705493
23sister chromatid segregation (GO:0000819)5.31205911
24regulation of histone H3-K9 methylation (GO:0051570)5.30054196
25* somatic diversification of immune receptors (GO:0002200)5.18077918
26* T cell differentiation (GO:0030217)5.11099721
27antigen receptor-mediated signaling pathway (GO:0050851)5.10444699
28interleukin-6-mediated signaling pathway (GO:0070102)5.10293643
29negative regulation of sodium ion transport (GO:0010766)5.02475091
30positive regulation of interleukin-2 production (GO:0032743)4.98287355
31replicative senescence (GO:0090399)4.95074052
32negative regulation of cell aging (GO:0090344)4.93163700
33regulation of translation in response to stress (GO:0043555)4.79910220
34modulation by symbiont of host cellular process (GO:0044068)4.79772816
35positive regulation of B cell differentiation (GO:0045579)4.76422463
36adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.63915373
37hepatocyte differentiation (GO:0070365)4.56829865
38positive regulation of histone H3-K4 methylation (GO:0051571)4.55893107
39mast cell activation (GO:0045576)4.51166679
40heparin biosynthetic process (GO:0030210)4.31279694
41heparin metabolic process (GO:0030202)4.31279694
42* B cell differentiation (GO:0030183)4.26995069
43regulation of chromatin silencing (GO:0031935)4.25150236
44* negative regulation of thymocyte apoptotic process (GO:0070244)4.24819351
45positive thymic T cell selection (GO:0045059)4.24605897
46interferon-gamma production (GO:0032609)4.23162629
47histone H3-K9 demethylation (GO:0033169)4.21709109
48poly(A)+ mRNA export from nucleus (GO:0016973)4.21293993
49purine ribonucleotide transport (GO:0015868)4.21145611
50regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.19214206
51regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.19214206
52regulation of interleukin-2 biosynthetic process (GO:0045076)4.15968091
53T cell lineage commitment (GO:0002360)4.15911647
54B cell receptor signaling pathway (GO:0050853)4.15622740
55DNA ligation (GO:0006266)4.13971973
56dentate gyrus development (GO:0021542)4.13556258
57establishment of integrated proviral latency (GO:0075713)4.10759558
58T cell costimulation (GO:0031295)4.10424764
59mast cell degranulation (GO:0043303)4.05614060
60mast cell activation involved in immune response (GO:0002279)4.05614060
61adenine nucleotide transport (GO:0051503)4.01892238
62lymphocyte costimulation (GO:0031294)4.00971323
63* T cell differentiation in thymus (GO:0033077)3.99708644
64negative regulation of cell killing (GO:0031342)3.98703662
65negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.98703662
66generation of neurons (GO:0048699)3.96795692
67positive regulation of gene expression, epigenetic (GO:0045815)3.94781479
68positive regulation by host of viral transcription (GO:0043923)3.94224407
69CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.91045903
70DNA replication initiation (GO:0006270)3.89170196
71protein-DNA complex disassembly (GO:0032986)3.88698376
72nucleosome disassembly (GO:0006337)3.88698376
73negative thymic T cell selection (GO:0045060)3.83212582
74centrosome duplication (GO:0051298)3.80433612
75positive regulation of organ growth (GO:0046622)3.79563815
76response to histamine (GO:0034776)3.78547685
77positive regulation of histone deacetylation (GO:0031065)3.77224570
78mitotic recombination (GO:0006312)3.74781664
79mitotic sister chromatid cohesion (GO:0007064)3.72901426
80regulation of interleukin-2 production (GO:0032663)3.71804233
81regulation of B cell differentiation (GO:0045577)3.70669928
82regulation of histone H3-K4 methylation (GO:0051569)3.68301653
83natural killer cell differentiation (GO:0001779)3.66335664
84regulation of T cell receptor signaling pathway (GO:0050856)3.65244019
85regulation of calcium-mediated signaling (GO:0050848)3.63083213
86thymic T cell selection (GO:0045061)3.60945521
87negative regulation of oligodendrocyte differentiation (GO:0048715)3.59064118
88attachment of spindle microtubules to kinetochore (GO:0008608)3.55724444
89regulation of DNA endoreduplication (GO:0032875)3.54746802
90* T cell activation (GO:0042110)3.53052204
91immune response-activating cell surface receptor signaling pathway (GO:0002429)3.51580570
92* lymphocyte differentiation (GO:0030098)3.51176451
93monoubiquitinated protein deubiquitination (GO:0035520)3.49939151
94regulation of defense response to virus by virus (GO:0050690)3.48902430
95CD4-positive, alpha-beta T cell activation (GO:0035710)3.48314152
96regulation of RNA export from nucleus (GO:0046831)3.47867185
97regulation of circadian sleep/wake cycle (GO:0042749)3.47195193
98regulation of circadian sleep/wake cycle, sleep (GO:0045187)3.47195193
99DNA biosynthetic process (GO:0071897)3.47131608
100musculoskeletal movement (GO:0050881)3.44658437
101multicellular organismal movement (GO:0050879)3.44658437
102regulation of regulatory T cell differentiation (GO:0045589)3.42437137
103entry into host cell (GO:0030260)3.40817247
104movement in environment of other organism involved in symbiotic interaction (GO:0052192)3.40817247
105entry into cell of other organism involved in symbiotic interaction (GO:0051806)3.40817247
106entry into host (GO:0044409)3.40817247
107entry into other organism involved in symbiotic interaction (GO:0051828)3.40817247
108movement in host environment (GO:0052126)3.40817247
109serine transport (GO:0032329)3.39333592
110T cell proliferation (GO:0042098)3.38712836
111L-serine transport (GO:0015825)3.38578363
112DNA unwinding involved in DNA replication (GO:0006268)3.35420264
113regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.34911329
114regulation of proton transport (GO:0010155)3.34180617
115prepulse inhibition (GO:0060134)3.32010774
116* B cell activation (GO:0042113)3.31347537
117positive regulation of renal sodium excretion (GO:0035815)3.28969583
118cellular response to osmotic stress (GO:0071470)3.24572060
119synaptic transmission, dopaminergic (GO:0001963)3.24152325
120positive regulation of granulocyte differentiation (GO:0030854)3.24047188
121regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.23096900
122G-protein coupled receptor internalization (GO:0002031)3.22959656
123B cell proliferation (GO:0042100)3.21181818
124purine nucleotide transport (GO:0015865)3.19650361
125regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.14906004
126DNA topological change (GO:0006265)3.14280588
127regulation of histone methylation (GO:0031060)3.13370625
128neural tube development (GO:0021915)3.13246541
129negative regulation of histone methylation (GO:0031061)3.11150365
130positive regulation of protein homooligomerization (GO:0032464)3.08919924
131lymphocyte proliferation (GO:0046651)3.07944891
132negative regulation of gene silencing (GO:0060969)3.07819658
133hepatocyte apoptotic process (GO:0097284)3.05850046
134mononuclear cell proliferation (GO:0032943)3.05249005
135establishment of viral latency (GO:0019043)3.02671716
136behavioral response to cocaine (GO:0048148)3.01083446
137SMAD protein complex assembly (GO:0007183)3.00950066
138positive regulation of alpha-beta T cell proliferation (GO:0046641)2.98201483
139positive regulation of T cell differentiation (GO:0045582)2.97668330
140negative regulation of erythrocyte differentiation (GO:0045647)2.97502855
141T cell mediated immunity (GO:0002456)2.96661860
142regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.94813853
143histone H4 deacetylation (GO:0070933)2.94465628
144mitotic DNA integrity checkpoint (GO:0044774)2.93522600
145regulation of granulocyte differentiation (GO:0030852)2.92650347
146DNA duplex unwinding (GO:0032508)2.91553092
147positive regulation of T-helper cell differentiation (GO:0045624)2.88497704
148chromatin silencing (GO:0006342)2.85507776
149nuclear pore organization (GO:0006999)2.79098882
150DNA geometric change (GO:0032392)2.78805593
151cellular response to UV (GO:0034644)2.76656999
152regulation of neurotransmitter uptake (GO:0051580)2.76589905
153negative regulation of translational initiation (GO:0045947)2.74588631
154leukocyte proliferation (GO:0070661)2.74115469
155spermatid nucleus differentiation (GO:0007289)2.73454832
156regulation of nucleobase-containing compound transport (GO:0032239)2.72388962
157regulation of dopamine secretion (GO:0014059)2.72032186
158response to pheromone (GO:0019236)2.72029267
159keratinocyte development (GO:0003334)2.70376730
160regulation of germinal center formation (GO:0002634)2.67822885
161positive regulation of viral genome replication (GO:0045070)2.67380713
162negative regulation of T-helper cell differentiation (GO:0045623)2.66938767
163negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.66938767
164microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.65428577
165hematopoietic stem cell proliferation (GO:0071425)2.63525370
166circadian sleep/wake cycle process (GO:0022410)2.63225700
167regulation of dendritic cell antigen processing and presentation (GO:0002604)2.60437436
168histone H4-K5 acetylation (GO:0043981)2.57780233
169histone H4-K8 acetylation (GO:0043982)2.57780233
170arachidonic acid secretion (GO:0050482)2.55776023
171icosanoid secretion (GO:0032309)2.55776023
172* V(D)J recombination (GO:0033151)12.7827029
173regulation of gamma-delta T cell differentiation (GO:0045586)10.3606000
174cellular response to ethanol (GO:0071361)10.3604449

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.34146229
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.94987800
3BP1_19119308_ChIP-ChIP_Hs578T_Human6.79937761
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.96797611
5EGR1_19374776_ChIP-ChIP_THP-1_Human5.40285593
6MYC_22102868_ChIP-Seq_BL_Human4.86310339
7FOXM1_23109430_ChIP-Seq_U2OS_Human4.41439877
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.16043172
9RUNX_20019798_ChIP-Seq_JUKART_Human3.56770059
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.19702907
11VDR_21846776_ChIP-Seq_THP-1_Human3.19643895
12UTX_26944678_Chip-Seq_JUKART_Human3.03368972
13* MYB_26560356_Chip-Seq_TH2_Human2.99274378
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.97726557
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.92842670
16TCF7_22412390_ChIP-Seq_EML_Mouse2.70225830
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.61251625
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.59700225
19SCL_19346495_ChIP-Seq_HPC-7_Human2.58865098
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.57666931
21IGF1R_20145208_ChIP-Seq_DFB_Human2.46272086
22MAF_26560356_Chip-Seq_TH1_Human2.45328841
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.39364695
24KDM2B_26808549_Chip-Seq_DND41_Human2.28459088
25* GATA3_27048872_Chip-Seq_THYMUS_Human2.25763585
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.23852216
27GATA1_22025678_ChIP-Seq_K562_Human2.20445542
28MYB_26560356_Chip-Seq_TH1_Human2.18088266
29EWS_26573619_Chip-Seq_HEK293_Human2.14670444
30VDR_24763502_ChIP-Seq_THP-1_Human2.13379628
31CIITA_25753668_ChIP-Seq_RAJI_Human2.08338055
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01156288
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.97602578
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.94731436
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.86620441
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86212214
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73989583
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72182722
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67923406
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.66544996
41RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.56116690
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.50955692
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46423304
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46326968
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40257106
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38608059
47IRF1_19129219_ChIP-ChIP_H3396_Human1.34036801
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30845303
49SPI1_23127762_ChIP-Seq_K562_Human1.29243504
50KDM2B_26808549_Chip-Seq_JURKAT_Human1.27574612
51MAF_26560356_Chip-Seq_TH2_Human1.27259905
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24434526
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23829641
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.23405794
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22546969
56VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.22498555
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22398051
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21506240
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21358593
60MYC_18940864_ChIP-ChIP_HL60_Human1.20785333
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20428817
62* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20057083
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19802659
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.17507046
65IRF8_27001747_Chip-Seq_BMDM_Mouse1.17358134
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16935446
67VDR_23849224_ChIP-Seq_CD4+_Human1.16797543
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.15821031
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15708653
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.14987978
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14647502
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13243145
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.11780148
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09914042
75* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.09025994
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08873649
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.08446850
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.07810376
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06462710
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02149239
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02024402
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.01644338
83SPI1_23547873_ChIP-Seq_NB4_Human1.00904439
84PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00773505
85SMRT_27268052_Chip-Seq_Bcells_Human0.99249755
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98636218
87P300_27268052_Chip-Seq_Bcells_Human0.96812684
88ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95972790
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93708345
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92361760
91HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92034701
92ELK1_19687146_ChIP-ChIP_HELA_Human0.91862020
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91363496
94NCOR1_26117541_ChIP-Seq_K562_Human0.90315194
95EGR1_23403033_ChIP-Seq_LIVER_Mouse0.90125867
96GABP_17652178_ChIP-ChIP_JURKAT_Human0.89250152
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88857649
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87706472
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87628971
100RUNX1_27514584_Chip-Seq_MCF-7_Human0.87168815
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85715143
102ETS1_22383799_ChIP-Seq_G1ME_Mouse0.85339046
103CHD1_26751641_Chip-Seq_LNCaP_Human0.83816652
104ZFX_18555785_ChIP-Seq_MESCs_Mouse0.83510676
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83465428
106* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82536797
107DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82520312
108NANOG_21062744_ChIP-ChIP_HESCs_Human0.82118892
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81847372
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.81612547
111HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.81445487
112DNAJC2_21179169_ChIP-ChIP_NT2_Human0.80059751
113GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79412450
114KDM5A_27292631_Chip-Seq_BREAST_Human0.79187532
115GATA1_19941826_ChIP-Seq_K562_Human0.79035539
116NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.78564187
117FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.78472286
118IRF8_21731497_ChIP-ChIP_J774_Mouse0.78241541
119GATA3_26560356_Chip-Seq_TH2_Human0.77188983
120MYC_18555785_ChIP-Seq_MESCs_Mouse0.77136559
121CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.76775415
122GATA3_26560356_Chip-Seq_TH1_Human0.76405302
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.75816846
124ERG_20887958_ChIP-Seq_HPC-7_Mouse0.75574160
125VDR_24787735_ChIP-Seq_THP-1_Human0.74685335
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.74404918
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.73886143
128SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.73668354
129GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.73302854
130PU_27001747_Chip-Seq_BMDM_Mouse0.72248365
131GATA2_19941826_ChIP-Seq_K562_Human0.70051180
132FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.68982386
133IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.68871602
134CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.66460896
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.66459896
136FOXP3_21729870_ChIP-Seq_TREG_Human0.65246731
137CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.64996773
138RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63540391
139RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.62413321
140SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.62377499
141LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.62180093
142PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.61849120

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition6.82196204
2MP0005409_darkened_coat_color6.03472790
3MP0003763_abnormal_thymus_physiology4.83271152
4* MP0000703_abnormal_thymus_morphology4.51858139
5MP0009278_abnormal_bone_marrow3.98678612
6MP0005671_abnormal_response_to3.82411400
7MP0000685_abnormal_immune_system3.44565310
8MP0004808_abnormal_hematopoietic_stem3.01318373
9* MP0002398_abnormal_bone_marrow2.94718922
10MP0000015_abnormal_ear_pigmentation2.77523341
11MP0004084_abnormal_cardiac_muscle2.77403825
12* MP0002722_abnormal_immune_system2.66217820
13MP0005174_abnormal_tail_pigmentation2.58964524
14MP0001790_abnormal_immune_system2.45667817
15MP0005387_immune_system_phenotype2.45667817
16MP0006054_spinal_hemorrhage2.36415024
17* MP0000716_abnormal_immune_system2.36133990
18* MP0000689_abnormal_spleen_morphology2.32726296
19MP0005397_hematopoietic_system_phenotyp2.32555025
20MP0001545_abnormal_hematopoietic_system2.32555025
21* MP0001800_abnormal_humoral_immune2.29771626
22* MP0010155_abnormal_intestine_physiology2.21311619
23* MP0004947_skin_inflammation2.17976327
24MP0004381_abnormal_hair_follicle2.04756522
25* MP0010094_abnormal_chromosome_stability2.01363978
26* MP0002420_abnormal_adaptive_immunity1.97992028
27* MP0001819_abnormal_immune_cell1.94227570
28MP0006082_CNS_inflammation1.89503825
29* MP0002429_abnormal_blood_cell1.87778670
30MP0002876_abnormal_thyroid_physiology1.85506489
31MP0002405_respiratory_system_inflammati1.81987333
32MP0005075_abnormal_melanosome_morpholog1.80980566
33* MP0002723_abnormal_immune_serum1.78938187
34* MP0002166_altered_tumor_susceptibility1.76780644
35MP0003300_gastrointestinal_ulcer1.76515706
36MP0009333_abnormal_splenocyte_physiolog1.67683962
37MP0005076_abnormal_cell_differentiation1.65790141
38MP0002396_abnormal_hematopoietic_system1.65118608
39* MP0002452_abnormal_antigen_presenting1.60015312
40MP0004130_abnormal_muscle_cell1.58416971
41MP0005365_abnormal_bile_salt1.56386700
42* MP0005000_abnormal_immune_tolerance1.47580189
43MP0004036_abnormal_muscle_relaxation1.43223405
44* MP0009785_altered_susceptibility_to1.39713754
45MP0000462_abnormal_digestive_system1.39233814
46MP0008569_lethality_at_weaning1.35151091
47MP0000383_abnormal_hair_follicle1.34559907
48MP0000920_abnormal_myelination1.31411129
49* MP0002019_abnormal_tumor_incidence1.24039882
50MP0000490_abnormal_crypts_of1.23665858
51* MP0005025_abnormal_response_to1.22477086
52MP0006035_abnormal_mitochondrial_morpho1.19598739
53MP0010352_gastrointestinal_tract_polyps1.17679459
54* MP0002006_tumorigenesis1.15967479
55MP0008961_abnormal_basal_metabolism1.15587845
56MP0010678_abnormal_skin_adnexa1.14616036
57MP0003283_abnormal_digestive_organ1.14328759
58MP0003303_peritoneal_inflammation1.12863096
59MP0009697_abnormal_copulation1.11794045
60MP0008057_abnormal_DNA_replication1.08728839
61MP0003866_abnormal_defecation1.08587776
62MP0000470_abnormal_stomach_morphology1.07378477
63* MP0001845_abnormal_inflammatory_respons1.06989515
64MP0003077_abnormal_cell_cycle1.05812705
65MP0003879_abnormal_hair_cell1.05004955
66MP0002148_abnormal_hypersensitivity_rea1.04625134
67MP0003959_abnormal_lean_body1.00295661
68MP0005220_abnormal_exocrine_pancreas0.98789502
69MP0002138_abnormal_hepatobiliary_system0.96834376
70* MP0002095_abnormal_skin_pigmentation0.96494816
71MP0002127_abnormal_cardiovascular_syste0.96243316
72MP0002009_preneoplasia0.96197056
73MP0003787_abnormal_imprinting0.92943101
74MP0008007_abnormal_cellular_replicative0.92535036
75MP0005464_abnormal_platelet_physiology0.91771177
76MP0001663_abnormal_digestive_system0.91259944
77MP0003111_abnormal_nucleus_morphology0.90762177
78MP0002060_abnormal_skin_morphology0.90014600
79MP0008775_abnormal_heart_ventricle0.89386339
80MP0002970_abnormal_white_adipose0.87551195
81MP0000350_abnormal_cell_proliferation0.87306775
82* MP0001835_abnormal_antigen_presentation0.81077429
83MP0001853_heart_inflammation0.79703146
84MP0008058_abnormal_DNA_repair0.78417453
85MP0005670_abnormal_white_adipose0.75604591
86MP0003693_abnormal_embryo_hatching0.74565585
87* MP0002083_premature_death0.72751745
88MP0003436_decreased_susceptibility_to0.71728719
89MP0008872_abnormal_physiological_respon0.70427512
90MP0001915_intracranial_hemorrhage0.69979192
91MP0002971_abnormal_brown_adipose0.69130286
92MP0004197_abnormal_fetal_growth/weight/0.67862456
93MP0005501_abnormal_skin_physiology0.66889517
94* MP0002075_abnormal_coat/hair_pigmentati0.64833592
95MP0010771_integument_phenotype0.63542046
96MP0005381_digestive/alimentary_phenotyp0.63444767
97MP0010234_abnormal_vibrissa_follicle0.63156841
98MP0005310_abnormal_salivary_gland0.62949827
99MP0000477_abnormal_intestine_morphology0.61669307
100* MP0008770_decreased_survivor_rate0.61545496
101MP0008877_abnormal_DNA_methylation0.61511378
102MP0003868_abnormal_feces_composition0.61064480
103MP0001697_abnormal_embryo_size0.60862017
104MP0001905_abnormal_dopamine_level0.60651809
105MP0004957_abnormal_blastocyst_morpholog0.60139944
106MP0002086_abnormal_extraembryonic_tissu0.59688707
107MP0009115_abnormal_fat_cell0.59445210
108MP0000377_abnormal_hair_follicle0.58713062
109MP0001529_abnormal_vocalization0.58704157
110MP0001730_embryonic_growth_arrest0.58509394
111MP0000733_abnormal_muscle_development0.58402858
112MP0003252_abnormal_bile_duct0.57393666
113MP0000858_altered_metastatic_potential0.57050019
114MP0005360_urolithiasis0.56574199
115MP0002877_abnormal_melanocyte_morpholog0.55693535
116MP0004264_abnormal_extraembryonic_tissu0.55560507
117MP0001340_abnormal_eyelid_morphology0.55225223
118MP0000465_gastrointestinal_hemorrhage0.54182043
119* MP0002419_abnormal_innate_immunity0.53518284
120MP0004043_abnormal_pH_regulation0.52652246
121MP0002796_impaired_skin_barrier0.52293710
122MP0001851_eye_inflammation0.52245146
123MP0003943_abnormal_hepatobiliary_system0.51563373
124MP0000313_abnormal_cell_death0.50595908
125MP0002160_abnormal_reproductive_system0.50278707
126MP0005334_abnormal_fat_pad0.50023645
127MP0008874_decreased_physiological_sensi0.49717935
128* MP0009931_abnormal_skin_appearance0.49302188
129MP0008932_abnormal_embryonic_tissue0.48892002
130MP0004185_abnormal_adipocyte_glucose0.46466257
131MP0006072_abnormal_retinal_apoptosis0.44466411
132MP0001542_abnormal_bone_strength0.43870059
133MP0006138_congestive_heart_failure0.41371730
134MP0002088_abnormal_embryonic_growth/wei0.39649972
135MP0001756_abnormal_urination0.37985839
136MP0004742_abnormal_vestibular_system0.36931989
137MP0003718_maternal_effect0.36643697
138MP0003935_abnormal_craniofacial_develop0.35802820
139MP0003984_embryonic_growth_retardation0.35367781
140MP0001672_abnormal_embryogenesis/_devel0.34374758
141MP0005380_embryogenesis_phenotype0.34374758

Predicted human phenotypes

RankGene SetZ-score
1* Abnormality of T cell number (HP:0011839)9.82307343
2* B lymphocytopenia (HP:0010976)9.53809237
3* Abnormality of B cell number (HP:0010975)9.53809237
4* Thyroiditis (HP:0100646)7.88960174
5* Recurrent viral infections (HP:0004429)7.41211586
6* Severe combined immunodeficiency (HP:0004430)7.25213230
7* Hypoplasia of the thymus (HP:0000778)7.04808547
8* Panhypogammaglobulinemia (HP:0003139)6.46334556
9* Eosinophilia (HP:0001880)6.46252439
10* Combined immunodeficiency (HP:0005387)6.32750749
11* Granulocytopenia (HP:0001913)5.06856527
12* Abnormality of eosinophils (HP:0001879)4.91772599
13Verrucae (HP:0200043)4.88872492
14Papilloma (HP:0012740)4.88872492
15* Abnormality of T cells (HP:0002843)4.74917297
16* Hypoproteinemia (HP:0003075)4.38658899
17Abnormality of the fingertips (HP:0001211)3.98953364
18* Recurrent fungal infections (HP:0002841)3.86290914
19Acute lymphatic leukemia (HP:0006721)3.77602403
20Agammaglobulinemia (HP:0004432)3.69317825
21Volvulus (HP:0002580)3.65979336
22* IgG deficiency (HP:0004315)3.59234777
23* Leukocytosis (HP:0001974)3.45670481
24Small epiphyses (HP:0010585)3.27030288
25Cellulitis (HP:0100658)3.11274713
26* Erythroderma (HP:0001019)3.00127068
27Deep philtrum (HP:0002002)2.86622124
28* Meningitis (HP:0001287)2.85868575
29Abnormality of the intervertebral disk (HP:0005108)2.82046637
30Flattened epiphyses (HP:0003071)2.75846174
31Vertebral arch anomaly (HP:0008438)2.72052237
32Long eyelashes (HP:0000527)2.71759896
33Bicuspid aortic valve (HP:0001647)2.65527815
34* Sepsis (HP:0100806)2.58307727
35Recurrent pneumonia (HP:0006532)2.54532799
36Cutis marmorata (HP:0000965)2.54413497
37Carpal bone hypoplasia (HP:0001498)2.33649979
38* Aplasia/Hypoplasia of the thymus (HP:0010515)2.26189385
39Recurrent bronchitis (HP:0002837)2.24606992
40Mitral regurgitation (HP:0001653)2.17887261
41* Abnormality of the thymus (HP:0000777)2.12260077
42Recurrent otitis media (HP:0000403)2.10213847
43Autoimmune thrombocytopenia (HP:0001973)2.01399531
44* T lymphocytopenia (HP:0005403)10.4250166
45Aortic valve stenosis (HP:0001650)1.99469280
46Hypoplasia of the pons (HP:0012110)1.99463129
47Macroorchidism (HP:0000053)1.99044935
48Abnormal delayed hypersensitivity skin test (HP:0002963)1.95299770
49Sparse lateral eyebrow (HP:0005338)1.95222942
50Wide intermamillary distance (HP:0006610)1.94879385
51Prostate neoplasm (HP:0100787)1.91981747
52Autoimmune hemolytic anemia (HP:0001890)1.91789101
53Abnormality of the pons (HP:0007361)1.90534789
54Recurrent cutaneous fungal infections (HP:0011370)1.90273467
55Chronic mucocutaneous candidiasis (HP:0002728)1.90273467
56Basal cell carcinoma (HP:0002671)1.90072295
57* Lymphoma (HP:0002665)1.87791827
58Recurrent lower respiratory tract infections (HP:0002783)1.87317769
59Hyperacusis (HP:0010780)1.87276614
60Bronchitis (HP:0012387)1.84991079
61Colitis (HP:0002583)1.84854800
62Gastrointestinal inflammation (HP:0004386)1.81507458
63Pustule (HP:0200039)1.81162698
64Osteomyelitis (HP:0002754)1.80667973
65Limited elbow extension (HP:0001377)1.77041231
66Inflammation of the large intestine (HP:0002037)1.73537530
67Increased nuchal translucency (HP:0010880)1.72699184
68Abnormality of chromosome segregation (HP:0002916)1.71854264
69Lymphopenia (HP:0001888)1.70932721
70Abnormality of cells of the lymphoid lineage (HP:0012140)1.69694548
71Abnormality of endocrine pancreas physiology (HP:0012093)1.69606526
72Abnormality of the pancreatic islet cells (HP:0006476)1.69606526
73Dehydration (HP:0001944)1.69479269
74Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.68166051
75Truncal obesity (HP:0001956)1.67115684
76Abnormal foot bone ossification (HP:0010675)1.66654492
77Sparse scalp hair (HP:0002209)1.61673161
7811 pairs of ribs (HP:0000878)1.59275029
79Bronchiectasis (HP:0002110)1.59210090
80Chronic sinusitis (HP:0011109)1.57026876
81Abnormality of the prostate (HP:0008775)1.56942577
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.56774955
83Low anterior hairline (HP:0000294)1.55435933
84Cutaneous melanoma (HP:0012056)1.54923936
85Methylmalonic acidemia (HP:0002912)1.53629991
86Mitral stenosis (HP:0001718)1.53076745
87Chronic hepatic failure (HP:0100626)1.52361847
88Hypoplasia of the capital femoral epiphysis (HP:0003090)1.51813674
89Proximal placement of thumb (HP:0009623)1.51626544
90Weak cry (HP:0001612)1.50036285
91Abnormal pancreas size (HP:0012094)1.47059121
92Heterotopia (HP:0002282)1.46673042
93Ulnar bowing (HP:0003031)1.45297101
94Generalized hypotonia (HP:0001290)1.45100421
95Chromsome breakage (HP:0040012)1.42609491
96Recurrent sinusitis (HP:0011108)1.41055939
97Patellar aplasia (HP:0006443)1.40873312
98Irregular vertebral endplates (HP:0003301)1.40558216
99External ear malformation (HP:0008572)1.39579710
100Obsessive-compulsive behavior (HP:0000722)1.39045721
101Squamous cell carcinoma (HP:0002860)1.38825761
102Nonimmune hydrops fetalis (HP:0001790)1.38713557
103Spontaneous hematomas (HP:0007420)1.37787210
104Abnormality of the columella (HP:0009929)1.37322445
105Abnormality of oral frenula (HP:0000190)1.37045998
106Chromosomal breakage induced by crosslinking agents (HP:0003221)1.34778132
107Abnormality of the vertebral endplates (HP:0005106)1.34064005
108Sandal gap (HP:0001852)1.33300402
109Type 2 muscle fiber atrophy (HP:0003554)1.32799548
110Thick eyebrow (HP:0000574)1.31706208
111Elevated erythrocyte sedimentation rate (HP:0003565)1.31474633
112Deviation of the thumb (HP:0009603)1.30839293
113Encephalitis (HP:0002383)1.30449427
114Muscle fiber atrophy (HP:0100295)1.29352395
115IgM deficiency (HP:0002850)1.29277956
116Lower limb hyperreflexia (HP:0002395)1.29199101
117Broad palm (HP:0001169)1.27499336
118Barrel-shaped chest (HP:0001552)1.27174534
119* Pruritus (HP:0000989)1.26133624
120Pseudobulbar signs (HP:0002200)1.26085633
121Subaortic stenosis (HP:0001682)1.25043478
122Abnormality of the left ventricular outflow tract (HP:0011103)1.25043478
123Abnormal tarsal ossification (HP:0008369)1.24612937
124Periodontitis (HP:0000704)1.24440531
125Aplasia/Hypoplasia of the patella (HP:0006498)1.24435549
126Skin rash (HP:0000988)1.24229729
127Abnormality of the renal collecting system (HP:0004742)1.21365421
128Hematochezia (HP:0002573)1.21341467
129Albinism (HP:0001022)1.18488469
130Papilledema (HP:0001085)1.15746384
131Chronic diarrhea (HP:0002028)1.14510368
132Overlapping toe (HP:0001845)1.14208088
133Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.13454006
134Acute hepatic failure (HP:0006554)1.12660087
135Colon cancer (HP:0003003)1.12151219
136Duplicated collecting system (HP:0000081)1.11678047
137Rhabdomyosarcoma (HP:0002859)1.07786836
138Constricted visual fields (HP:0001133)1.07348832
139Abnormality of homocysteine metabolism (HP:0010919)1.07345271
140Homocystinuria (HP:0002156)1.07345271
141Prominent nose (HP:0000448)1.06619062
142Abnormality of chromosome stability (HP:0003220)1.06164341
143Periauricular skin pits (HP:0100277)1.06159575
144Preauricular pit (HP:0004467)1.06159575
145Nephroblastoma (Wilms tumor) (HP:0002667)1.05177763
146Abnormality of male internal genitalia (HP:0000022)1.04228266
147Methylmalonic aciduria (HP:0012120)1.03968678
148* Nephrotic syndrome (HP:0000100)1.02974905
149Ankyloglossia (HP:0010296)1.00827693
150Poikiloderma (HP:0001029)0.99113647
151Toxemia of pregnancy (HP:0100603)0.98172204
152* Hypothyroidism (HP:0000821)0.96448283
153Embryonal renal neoplasm (HP:0011794)0.95817285
154Short 4th metacarpal (HP:0010044)0.94935663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K106.20926332
2MET5.19110036
3TXK5.16303659
4MAP3K134.31558332
5BMPR1B3.96874416
6YES13.30961843
7GRK63.27021304
8MAP4K13.02005325
9PIK3CG2.72509152
10TGFBR12.64084785
11CDK82.63293214
12MAPK72.60414997
13SYK2.43728518
14SCYL22.40899521
15CDK122.37399126
16ZAP702.18987583
17TAF12.17905037
18PDGFRB2.14502444
19PKN22.04531394
20MAP3K71.98309038
21ITK1.87478707
22FGFR21.84501902
23RPS6KB11.80960677
24EEF2K1.78635349
25SIK21.77156764
26MAP3K141.68070478
27CSNK1A1L1.67989412
28SMG11.66938058
29VRK21.65891139
30MST41.61185340
31STK41.59670442
32ZAK1.58045244
33SRPK11.57163034
34CAMKK21.56550291
35STK101.51067006
36MAPK41.48657942
37CSNK1G31.42079473
38CDK71.41831614
39RIPK41.40525179
40MAPK121.39391653
41HCK1.37383414
42BRD41.34551800
43RPS6KB21.33255444
44ERN11.32069574
45NEK21.31641231
46CSK1.30801929
47CDK31.27940270
48MARK21.25557762
49FGFR31.23659958
50CSNK1G21.22591382
51LCK1.21122173
52CDK61.16811230
53TRIB31.16414722
54CSNK1G11.15965749
55CDK41.12585493
56DYRK1B1.11266950
57PRKCQ1.05026806
58CDK90.99839741
59BTK0.99818672
60EIF2AK30.98814712
61HIPK20.96903660
62CLK10.96563312
63TYRO30.95901993
64CDC70.95774062
65CAMKK10.95387365
66PTK60.91435742
67VRK10.90728926
68NLK0.88468445
69TYK20.87926379
70TLK10.87442058
71PRKD10.85477220
72LRRK20.85428813
73CAMK10.84306600
74MKNK10.79651711
75RPS6KL10.78913155
76RPS6KC10.78913155
77FGFR40.77654709
78KIT0.77368336
79MARK30.76266255
80FRK0.72151289
81PIM10.70476641
82RPS6KA60.70219345
83FYN0.69584760
84CAMK40.65339042
85WNK10.64235891
86MAPK110.62989724
87STK110.62635591
88INSR0.62631450
89CSNK1D0.62350894
90MKNK20.61163011
91ICK0.59994711
92MELK0.59776059
93MAP2K20.59663715
94SGK30.59450250
95LYN0.58755849
96CHEK20.57330951
97DYRK30.55513412
98TGFBR20.55345862
99CHEK10.54078367
100PLK40.53491550
101NEK10.51005199
102UHMK10.50290433
103PRKCH0.50054645
104TESK20.47976436
105DYRK1A0.47369581
106RET0.47267128
107ERBB20.47095694
108TTK0.46715107
109MAP3K80.46090038
110CAMK1D0.43850656
111ATR0.43093568
112JAK20.42150202
113PRKD20.41771498
114FES0.41590434
115MAPKAPK30.41121100
116MAPK30.40867632
117CAMK1G0.40267435
118NTRK20.37921238
119CSF1R0.36933960
120AURKB0.36274154
121TNK20.35854932
122EGFR0.35161709
123ATM0.33821606
124TEC0.33575199
125PLK20.33544899
126CDK20.33166858
127PAK20.33037385
128PRKDC0.32887581
129RPS6KA50.32244925
130MAP3K10.31867263
131MAPK90.30136222
132MAPKAPK50.29972267
133MAPK130.29941094
134SIK10.29889606
135MAPK140.26090678
136MAPK80.25387101
137DAPK10.25004690
138PRPF4B0.24931875
139ARAF0.24562119
140RPS6KA40.24555457
141FLT30.24422728
142NUAK10.24050957
143PIM20.23744566
144SIK30.23686490
145BUB10.20433753
146SGK10.17718559
147EIF2AK20.16539441
148PLK10.16344428

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary immunodeficiency_Homo sapiens_hsa053407.90749293
2Non-homologous end-joining_Homo sapiens_hsa034506.02690028
3T cell receptor signaling pathway_Homo sapiens_hsa046603.99902168
4Antigen processing and presentation_Homo sapiens_hsa046122.55214161
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.49288582
6Homologous recombination_Homo sapiens_hsa034402.38606217
7B cell receptor signaling pathway_Homo sapiens_hsa046622.37862421
8Hematopoietic cell lineage_Homo sapiens_hsa046402.37179617
9Caffeine metabolism_Homo sapiens_hsa002322.30783256
10Thyroid cancer_Homo sapiens_hsa052162.01882757
11Chronic myeloid leukemia_Homo sapiens_hsa052201.89663219
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.87881137
13Acute myeloid leukemia_Homo sapiens_hsa052211.75639865
14Fanconi anemia pathway_Homo sapiens_hsa034601.67801965
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.63141424
16Endometrial cancer_Homo sapiens_hsa052131.62217198
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.57411939
18Colorectal cancer_Homo sapiens_hsa052101.57377825
19Nucleotide excision repair_Homo sapiens_hsa034201.50976291
20Systemic lupus erythematosus_Homo sapiens_hsa053221.50614542
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.45594386
22Non-small cell lung cancer_Homo sapiens_hsa052231.43600763
23Lysine degradation_Homo sapiens_hsa003101.40756819
24Sulfur relay system_Homo sapiens_hsa041221.37689301
25Prostate cancer_Homo sapiens_hsa052151.35772710
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28669997
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.26721216
28Osteoclast differentiation_Homo sapiens_hsa043801.24154203
29Viral carcinogenesis_Homo sapiens_hsa052031.19884532
30HTLV-I infection_Homo sapiens_hsa051661.17789184
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15585799
32Dorso-ventral axis formation_Homo sapiens_hsa043201.14950625
33RNA transport_Homo sapiens_hsa030131.14340333
34Measles_Homo sapiens_hsa051621.14175604
35Renin-angiotensin system_Homo sapiens_hsa046141.12984969
36Alcoholism_Homo sapiens_hsa050341.07766563
37Asthma_Homo sapiens_hsa053101.06736096
38* FoxO signaling pathway_Homo sapiens_hsa040681.02365736
39Hepatitis B_Homo sapiens_hsa051611.01718108
40Cell cycle_Homo sapiens_hsa041101.01397454
41Allograft rejection_Homo sapiens_hsa053301.01046765
42Autoimmune thyroid disease_Homo sapiens_hsa053200.99358630
43Chemokine signaling pathway_Homo sapiens_hsa040620.99052315
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98448388
45Graft-versus-host disease_Homo sapiens_hsa053320.93732350
46ErbB signaling pathway_Homo sapiens_hsa040120.93473591
47MicroRNAs in cancer_Homo sapiens_hsa052060.90570495
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90268563
49Platelet activation_Homo sapiens_hsa046110.83643985
50mRNA surveillance pathway_Homo sapiens_hsa030150.83063708
51Pancreatic cancer_Homo sapiens_hsa052120.82934173
52Spliceosome_Homo sapiens_hsa030400.82268196
53Adherens junction_Homo sapiens_hsa045200.80025770
54Glioma_Homo sapiens_hsa052140.79560017
55Choline metabolism in cancer_Homo sapiens_hsa052310.74571035
56RNA polymerase_Homo sapiens_hsa030200.74220285
57Herpes simplex infection_Homo sapiens_hsa051680.72264476
58Circadian rhythm_Homo sapiens_hsa047100.71540869
59Long-term potentiation_Homo sapiens_hsa047200.71263117
60Base excision repair_Homo sapiens_hsa034100.69921958
61Melanoma_Homo sapiens_hsa052180.69703654
62Basal cell carcinoma_Homo sapiens_hsa052170.68881974
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67239409
64Type I diabetes mellitus_Homo sapiens_hsa049400.66369471
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65741262
66DNA replication_Homo sapiens_hsa030300.65242515
67mTOR signaling pathway_Homo sapiens_hsa041500.65017392
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63684303
69Pyrimidine metabolism_Homo sapiens_hsa002400.62537803
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.62287807
71Mismatch repair_Homo sapiens_hsa034300.62200145
72Wnt signaling pathway_Homo sapiens_hsa043100.61311906
73Small cell lung cancer_Homo sapiens_hsa052220.59454313
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57218858
75Insulin resistance_Homo sapiens_hsa049310.55204248
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.54426214
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52422094
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52271450
79Renal cell carcinoma_Homo sapiens_hsa052110.52066973
80Melanogenesis_Homo sapiens_hsa049160.51582200
81Pathways in cancer_Homo sapiens_hsa052000.50621544
82Purine metabolism_Homo sapiens_hsa002300.49658557
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49363038
84Epstein-Barr virus infection_Homo sapiens_hsa051690.47031442
85Phototransduction_Homo sapiens_hsa047440.45821160
86N-Glycan biosynthesis_Homo sapiens_hsa005100.45802304
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44857959
88Leishmaniasis_Homo sapiens_hsa051400.44835884
89Glycerolipid metabolism_Homo sapiens_hsa005610.43020005
90Estrogen signaling pathway_Homo sapiens_hsa049150.42956237
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42461535
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41767693
93Selenocompound metabolism_Homo sapiens_hsa004500.41133915
94Toxoplasmosis_Homo sapiens_hsa051450.39826388
95Proteoglycans in cancer_Homo sapiens_hsa052050.39820786
96Viral myocarditis_Homo sapiens_hsa054160.39302943
97Type II diabetes mellitus_Homo sapiens_hsa049300.39049629
98Insulin signaling pathway_Homo sapiens_hsa049100.39001701
99Apoptosis_Homo sapiens_hsa042100.38133041
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37822291
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36450887
102Inositol phosphate metabolism_Homo sapiens_hsa005620.36256357
103VEGF signaling pathway_Homo sapiens_hsa043700.36087771
104NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35894358
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35072457
106Basal transcription factors_Homo sapiens_hsa030220.34533999
107MAPK signaling pathway_Homo sapiens_hsa040100.33815125
108Olfactory transduction_Homo sapiens_hsa047400.32456443
109Influenza A_Homo sapiens_hsa051640.32376131
110Oxytocin signaling pathway_Homo sapiens_hsa049210.32013975
111RNA degradation_Homo sapiens_hsa030180.30574871
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30050249
113Endocytosis_Homo sapiens_hsa041440.29475954
114Gastric acid secretion_Homo sapiens_hsa049710.29264537
115Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28782170
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28599072
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27346477
118p53 signaling pathway_Homo sapiens_hsa041150.26760465
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26546084
120Fatty acid biosynthesis_Homo sapiens_hsa000610.26164619
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.25275432
122TGF-beta signaling pathway_Homo sapiens_hsa043500.25198798
123Prolactin signaling pathway_Homo sapiens_hsa049170.24121073
124Shigellosis_Homo sapiens_hsa051310.23654382
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23174099
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23172378
127Notch signaling pathway_Homo sapiens_hsa043300.22356437
128Oocyte meiosis_Homo sapiens_hsa041140.21790381
129One carbon pool by folate_Homo sapiens_hsa006700.20844871
130Linoleic acid metabolism_Homo sapiens_hsa005910.20472876
131Hedgehog signaling pathway_Homo sapiens_hsa043400.18540113
132Arachidonic acid metabolism_Homo sapiens_hsa005900.17798297
133Hepatitis C_Homo sapiens_hsa051600.16634912
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13910520
135Bladder cancer_Homo sapiens_hsa052190.12143653
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12059601
137Ras signaling pathway_Homo sapiens_hsa040140.11239692

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