RAG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ethanol (GO:0071361)8.73247724
2negative regulation of thymocyte apoptotic process (GO:0070244)8.31862498
3positive regulation of gamma-delta T cell activation (GO:0046645)7.91826126
4regulation of gamma-delta T cell differentiation (GO:0045586)7.41042056
5response to hydroperoxide (GO:0033194)7.31235909
6regulation of gamma-delta T cell activation (GO:0046643)6.92188970
7Peyers patch development (GO:0048541)6.02487886
8mucosal-associated lymphoid tissue development (GO:0048537)6.02487886
9resolution of meiotic recombination intermediates (GO:0000712)5.81287552
10cellular hyperosmotic response (GO:0071474)5.72590378
11replicative senescence (GO:0090399)5.56555260
12* somatic cell DNA recombination (GO:0016444)5.43131692
13* somatic diversification of immune receptors via germline recombination within a single locus (GO:0005.43131692
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.42989742
15positive regulation of B cell differentiation (GO:0045579)5.16639496
16DNA ligation (GO:0006266)5.16241305
17* somatic diversification of immune receptors (GO:0002200)4.97665372
18positive T cell selection (GO:0043368)4.95345648
19regulation of thymocyte apoptotic process (GO:0070243)4.92726283
20activated T cell proliferation (GO:0050798)4.81765328
21negative regulation of sodium ion transport (GO:0010766)4.76489074
22centrosome duplication (GO:0051298)4.73274806
23negative regulation of T cell apoptotic process (GO:0070233)4.70843133
24regulation of histone H3-K9 methylation (GO:0051570)4.62174033
25establishment of integrated proviral latency (GO:0075713)4.61026196
26DNA unwinding involved in DNA replication (GO:0006268)4.57389480
27B cell receptor signaling pathway (GO:0050853)4.57006406
28T cell selection (GO:0045058)4.48451495
29histone ubiquitination (GO:0016574)4.48428893
30T cell homeostasis (GO:0043029)4.33826247
31negative regulation of cell aging (GO:0090344)4.26316425
32regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.22692848
33regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.22692848
34adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.21564452
35dentate gyrus development (GO:0021542)4.20390394
36negative T cell selection (GO:0043383)4.19055047
37DNA topological change (GO:0006265)4.01836717
38serine transport (GO:0032329)4.01770970
39mast cell activation (GO:0045576)4.00030669
40positive regulation of histone H3-K4 methylation (GO:0051571)3.99830749
41positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.98757374
42thymus development (GO:0048538)3.95377621
43antigen receptor-mediated signaling pathway (GO:0050851)3.93869647
44regulation of DNA endoreduplication (GO:0032875)3.92485436
45positive regulation of granulocyte differentiation (GO:0030854)3.87605836
46regulation of B cell differentiation (GO:0045577)3.85789844
47T cell receptor signaling pathway (GO:0050852)3.81084801
48mast cell activation involved in immune response (GO:0002279)3.80779418
49mast cell degranulation (GO:0043303)3.80779418
50monoubiquitinated protein deubiquitination (GO:0035520)3.79152603
51establishment of viral latency (GO:0019043)3.78256878
52negative regulation of oligodendrocyte differentiation (GO:0048715)3.75153605
53labyrinthine layer development (GO:0060711)3.72270355
54* T cell differentiation (GO:0030217)3.70289742
55L-serine transport (GO:0015825)3.69279051
56positive regulation by host of viral transcription (GO:0043923)3.67355215
57interleukin-6-mediated signaling pathway (GO:0070102)3.67288120
58natural killer cell differentiation (GO:0001779)3.65451594
59regulation of T cell receptor signaling pathway (GO:0050856)3.65344485
60positive regulation of interleukin-2 production (GO:0032743)3.61622017
61regulation of chromatin silencing (GO:0031935)3.59840366
62negative regulation of lymphocyte apoptotic process (GO:0070229)3.59769507
63* T cell differentiation in thymus (GO:0033077)3.58420524
64multicellular organismal movement (GO:0050879)3.58023592
65musculoskeletal movement (GO:0050881)3.58023592
66sister chromatid segregation (GO:0000819)3.57242304
67prepulse inhibition (GO:0060134)3.56774548
68response to histamine (GO:0034776)3.55152302
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.54143675
70modulation by virus of host process (GO:0019054)3.53928172
71lymphocyte homeostasis (GO:0002260)3.53639805
72glucocorticoid receptor signaling pathway (GO:0042921)3.47139762
73synaptic transmission, dopaminergic (GO:0001963)3.46981062
74hepatocyte differentiation (GO:0070365)3.46026695
75mitotic chromosome condensation (GO:0007076)3.45922270
76DNA strand elongation involved in DNA replication (GO:0006271)3.44784262
77DNA replication initiation (GO:0006270)3.44206426
78behavioral response to cocaine (GO:0048148)3.43776062
79DNA strand elongation (GO:0022616)3.41887841
80protein localization to kinetochore (GO:0034501)3.38335391
81positive regulation of calcium-mediated signaling (GO:0050850)3.38154886
82protein-DNA complex disassembly (GO:0032986)3.33560759
83nucleosome disassembly (GO:0006337)3.33560759
84alpha-beta T cell differentiation (GO:0046632)3.32601307
85alpha-beta T cell activation (GO:0046631)3.31813940
86positive thymic T cell selection (GO:0045059)3.31777812
87mitotic sister chromatid cohesion (GO:0007064)3.31079553
88regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.28169926
89telomere maintenance via semi-conservative replication (GO:0032201)3.24918125
90mitotic sister chromatid segregation (GO:0000070)3.22494157
91G-protein coupled receptor internalization (GO:0002031)3.22493573
92heparin biosynthetic process (GO:0030210)3.21859607
93heparin metabolic process (GO:0030202)3.21859607
94DNA biosynthetic process (GO:0071897)3.21449992
95interferon-gamma production (GO:0032609)3.21332377
96mitotic recombination (GO:0006312)3.21260864
97regulation of circadian sleep/wake cycle, sleep (GO:0045187)3.21147029
98regulation of circadian sleep/wake cycle (GO:0042749)3.21147029
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.19069265
100antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.19059287
101antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.19059287
102regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.17855844
103* B cell activation (GO:0042113)3.16838483
104positive regulation of gene expression, epigenetic (GO:0045815)3.16518419
105regulation of lymphocyte apoptotic process (GO:0070228)3.16204362
106leukocyte homeostasis (GO:0001776)3.15528788
107meiotic chromosome segregation (GO:0045132)3.14466941
108protein localization to chromosome, centromeric region (GO:0071459)3.14348010
109histone monoubiquitination (GO:0010390)3.10778425
110poly(A)+ mRNA export from nucleus (GO:0016973)3.08417768
111positive regulation of renal sodium excretion (GO:0035815)3.04556071
112branching involved in labyrinthine layer morphogenesis (GO:0060670)3.02766244
113translesion synthesis (GO:0019985)3.01995043
114protein autoubiquitination (GO:0051865)3.01738419
115regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.97813894
116genitalia morphogenesis (GO:0035112)2.97551713
117regulation of regulatory T cell differentiation (GO:0045589)2.97103738
118telomere maintenance via recombination (GO:0000722)2.96806651
119regulation of granulocyte differentiation (GO:0030852)2.96570664
120protein monoubiquitination (GO:0006513)2.95237476
121regulation of T cell apoptotic process (GO:0070232)2.95018573
122regulation of proton transport (GO:0010155)2.92897606
123* lymphocyte differentiation (GO:0030098)2.91392137
124regulation of histone H3-K4 methylation (GO:0051569)2.90841954
125regulation of translation in response to stress (GO:0043555)2.88600710
126protein localization to chromosome (GO:0034502)2.85547810
127negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.84329183
128negative regulation of cell killing (GO:0031342)2.84329183
129* T cell activation (GO:0042110)2.84297930
130DNA synthesis involved in DNA repair (GO:0000731)2.83682060
131negative regulation of leukocyte apoptotic process (GO:2000107)2.83636601
132hepatocyte apoptotic process (GO:0097284)2.83574483
133nucleotide-excision repair, DNA gap filling (GO:0006297)2.82455392
134regulation of interleukin-2 production (GO:0032663)2.82208587
135modulation by symbiont of host cellular process (GO:0044068)2.81095104
136regulation of neurotransmitter uptake (GO:0051580)2.81033064
137inner cell mass cell proliferation (GO:0001833)2.79305076
138immune response-activating cell surface receptor signaling pathway (GO:0002429)2.78136999
139purine ribonucleotide transport (GO:0015868)2.75120434
140T cell costimulation (GO:0031295)2.74159407
141regulation of RNA export from nucleus (GO:0046831)2.73603554
142telomere maintenance (GO:0000723)2.73319276
143kinetochore organization (GO:0051383)2.72405340
144reflex (GO:0060004)2.71863290
145corticosteroid receptor signaling pathway (GO:0031958)2.71190757
146negative regulation of histone methylation (GO:0031061)2.69902709
147SMAD protein complex assembly (GO:0007183)2.69325694
148telomere organization (GO:0032200)2.69232405
149DNA duplex unwinding (GO:0032508)2.68262483
150* B cell differentiation (GO:0030183)2.68065608
151* DNA recombination (GO:0006310)2.67663965
152mitotic DNA integrity checkpoint (GO:0044774)2.67376951
153microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.58973475
154negative regulation of cell cycle G2/M phase transition (GO:1902750)2.58540789
155attachment of spindle microtubules to kinetochore (GO:0008608)2.57923214
156adenine nucleotide transport (GO:0051503)2.55221946
157hematopoietic stem cell proliferation (GO:0071425)2.54048161
158regulation of dopamine secretion (GO:0014059)2.53917984
159response to pheromone (GO:0019236)2.52294816
160keratinocyte development (GO:0003334)2.45640396
161regulation of germinal center formation (GO:0002634)2.44016309
162* V(D)J recombination (GO:0033151)11.1255487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.15801605
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.00180374
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.34010786
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.88633220
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.74504294
6MYC_22102868_ChIP-Seq_BL_Human3.62245400
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.55652474
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.09441414
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.96115820
10SCL_19346495_ChIP-Seq_HPC-7_Human2.90618203
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.77784044
12MYB_26560356_Chip-Seq_TH2_Human2.69836313
13RUNX_20019798_ChIP-Seq_JUKART_Human2.67317220
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.61819062
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.57161245
16VDR_21846776_ChIP-Seq_THP-1_Human2.50553337
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.29608040
18UTX_26944678_Chip-Seq_JUKART_Human2.19440147
19EWS_26573619_Chip-Seq_HEK293_Human2.00884654
20MYB_26560356_Chip-Seq_TH1_Human2.00248452
21E2F7_22180533_ChIP-Seq_HELA_Human11.1677791
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92913766
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.90715457
24MAF_26560356_Chip-Seq_TH1_Human1.90064406
25CIITA_25753668_ChIP-Seq_RAJI_Human1.89275837
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.87196432
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87100699
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.80332098
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.78960399
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73234321
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71058824
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.69429278
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68445165
34IRF1_19129219_ChIP-ChIP_H3396_Human1.67239190
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.66211268
36* VDR_24763502_ChIP-Seq_THP-1_Human1.66040530
37* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.61964586
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61812294
39* GATA3_27048872_Chip-Seq_THYMUS_Human1.61753367
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61543632
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57989004
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57684093
43VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.56582156
44* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56018224
45TCF7_22412390_ChIP-Seq_EML_Mouse1.51645574
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50293577
47MYC_18940864_ChIP-ChIP_HL60_Human1.48413492
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.48043736
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.47792200
50IGF1R_20145208_ChIP-Seq_DFB_Human1.46503837
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44989301
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43385248
53SPI1_23547873_ChIP-Seq_NB4_Human1.38630563
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38512014
55FUS_26573619_Chip-Seq_HEK293_Human1.32523175
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30989669
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30747462
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30177331
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29769358
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29234850
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29171717
62ZNF274_21170338_ChIP-Seq_K562_Hela1.28796334
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28584306
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27805807
65* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.27508636
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27200596
67FOXP3_21729870_ChIP-Seq_TREG_Human1.26733243
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26274749
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.26197262
70SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.23596072
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21488484
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18633690
73* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17761722
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15217236
75SPI1_23127762_ChIP-Seq_K562_Human1.15094991
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.14549945
77* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11821649
78VDR_23849224_ChIP-Seq_CD4+_Human1.10842901
79GABP_17652178_ChIP-ChIP_JURKAT_Human1.09977326
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09932095
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07681907
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06334994
83CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05921714
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.05624160
85AR_21909140_ChIP-Seq_LNCAP_Human1.04879137
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97005990
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96808496
88ELK1_19687146_ChIP-ChIP_HELA_Human0.92695248
89GATA3_26560356_Chip-Seq_TH2_Human0.91595744
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89140219
91MAF_26560356_Chip-Seq_TH2_Human0.88526161
92PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87803264
93YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87275690
94P300_27268052_Chip-Seq_Bcells_Human0.86295916
95ETS1_22383799_ChIP-Seq_G1ME_Mouse0.86283622
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85946168
97ER_23166858_ChIP-Seq_MCF-7_Human0.85182434
98KDM2B_26808549_Chip-Seq_DND41_Human0.83565737
99GATA1_22025678_ChIP-Seq_K562_Human0.83045146
100PU_27001747_Chip-Seq_BMDM_Mouse0.81850372
101GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80798264
102CTCF_21964334_ChIP-Seq_BJAB-B_Human0.80550118
103SOX2_16153702_ChIP-ChIP_HESCs_Human0.80312579
104PKCTHETA_26484144_Chip-Seq_BREAST_Human0.79839615
105SMRT_27268052_Chip-Seq_Bcells_Human0.79655525
106TTF2_22483619_ChIP-Seq_HELA_Human0.78531757
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77407119
108HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.76202833
109* PRDM14_20953172_ChIP-Seq_ESCs_Human0.75567428
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75550690
111ETS1_20019798_ChIP-Seq_JURKAT_Human0.75528329
112GF1_26923725_Chip-Seq_HPCs_Mouse0.75525774
113NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.75505287
114VDR_24787735_ChIP-Seq_THP-1_Human0.74153071
115EST1_17652178_ChIP-ChIP_JURKAT_Human0.74108503
116RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72213289
117PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.71763766
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.71227380
119GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.69912343
120MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.68414779
121EGR1_23403033_ChIP-Seq_LIVER_Mouse0.67789795
122PU.1_20513432_ChIP-Seq_Bcells_Mouse0.67316173
123KDM5A_27292631_Chip-Seq_BREAST_Human0.67305748
124E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.66788154
125MYC_19030024_ChIP-ChIP_MESCs_Mouse0.64773356
126CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.63640563
127BP1_19119308_ChIP-ChIP_Hs578T_Human0.62909624
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.62847891
129GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.62800268
130KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.62662002
131PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.62607029
132PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.61595942
133KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.60589687

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition6.06724855
2MP0002166_altered_tumor_susceptibility4.11409369
3MP0000685_abnormal_immune_system3.78404672
4MP0003763_abnormal_thymus_physiology3.76648296
5MP0005409_darkened_coat_color3.50708058
6MP0002006_tumorigenesis3.40861154
7* MP0000703_abnormal_thymus_morphology3.38003350
8MP0001835_abnormal_antigen_presentation3.33591768
9MP0002132_abnormal_respiratory_system3.19246894
10* MP0010094_abnormal_chromosome_stability3.16439464
11* MP0002398_abnormal_bone_marrow2.93730413
12MP0002396_abnormal_hematopoietic_system2.88504955
13* MP0001800_abnormal_humoral_immune2.82709544
14MP0004808_abnormal_hematopoietic_stem2.73526951
15* MP0005671_abnormal_response_to2.52057020
16* MP0002722_abnormal_immune_system2.50665458
17MP0000689_abnormal_spleen_morphology2.48152705
18* MP0000716_abnormal_immune_system2.41520739
19* MP0009785_altered_susceptibility_to2.40834018
20MP0002095_abnormal_skin_pigmentation2.35879943
21* MP0002420_abnormal_adaptive_immunity2.28913563
22* MP0001819_abnormal_immune_cell2.26336194
23* MP0002452_abnormal_antigen_presenting2.22393352
24* MP0002723_abnormal_immune_serum2.20950760
25MP0005174_abnormal_tail_pigmentation2.20642816
26MP0003693_abnormal_embryo_hatching2.11029273
27* MP0001790_abnormal_immune_system2.10336818
28* MP0005387_immune_system_phenotype2.10336818
29MP0005000_abnormal_immune_tolerance2.02218098
30MP0008057_abnormal_DNA_replication2.01820100
31MP0000015_abnormal_ear_pigmentation1.98877036
32* MP0002429_abnormal_blood_cell1.98370015
33MP0003111_abnormal_nucleus_morphology1.88674219
34MP0004084_abnormal_cardiac_muscle1.88254568
35* MP0010155_abnormal_intestine_physiology1.87202143
36MP0006054_spinal_hemorrhage1.86808533
37MP0003077_abnormal_cell_cycle1.84246861
38* MP0004947_skin_inflammation1.75103157
39* MP0005025_abnormal_response_to1.73207248
40MP0001879_abnormal_lymphatic_vessel1.65360489
41MP0002933_joint_inflammation1.64402994
42MP0001849_ear_inflammation1.59346108
43MP0008007_abnormal_cellular_replicative1.55481445
44MP0009333_abnormal_splenocyte_physiolog1.52933271
45MP0001853_heart_inflammation1.51295626
46MP0008058_abnormal_DNA_repair1.44838918
47* MP0002019_abnormal_tumor_incidence1.43813417
48MP0008877_abnormal_DNA_methylation1.38771303
49MP0002075_abnormal_coat/hair_pigmentati1.37944963
50* MP0002419_abnormal_innate_immunity1.36858452
51* MP0002405_respiratory_system_inflammati1.36542600
52MP0006082_CNS_inflammation1.35966309
53MP0009697_abnormal_copulation1.29449933
54MP0003283_abnormal_digestive_organ1.29252125
55* MP0001845_abnormal_inflammatory_respons1.21727288
56MP0005464_abnormal_platelet_physiology1.19312414
57MP0003436_decreased_susceptibility_to1.19162323
58MP0003787_abnormal_imprinting1.14855162
59MP0008872_abnormal_physiological_respon1.14136557
60* MP0002148_abnormal_hypersensitivity_rea1.13357070
61MP0004957_abnormal_blastocyst_morpholog1.09108859
62MP0001186_pigmentation_phenotype1.08142420
63MP0005645_abnormal_hypothalamus_physiol1.06158805
64* MP0000490_abnormal_crypts_of1.05645235
65MP0005220_abnormal_exocrine_pancreas1.05390205
66MP0003300_gastrointestinal_ulcer1.03975305
67MP0001873_stomach_inflammation1.02941861
68MP0004036_abnormal_muscle_relaxation0.95637982
69* MP0001545_abnormal_hematopoietic_system0.92354484
70* MP0005397_hematopoietic_system_phenotyp0.92354484
71MP0002160_abnormal_reproductive_system0.91652638
72MP0000350_abnormal_cell_proliferation0.90022149
73MP0003866_abnormal_defecation0.86951057
74MP0005075_abnormal_melanosome_morpholog0.85184167
75MP0003724_increased_susceptibility_to0.83402333
76MP0001905_abnormal_dopamine_level0.82517759
77MP0003303_peritoneal_inflammation0.80522416
78MP0002653_abnormal_ependyma_morphology0.79046204
79MP0000858_altered_metastatic_potential0.78859403
80MP0000013_abnormal_adipose_tissue0.78523795
81MP0001243_abnormal_dermal_layer0.77056567
82MP0005670_abnormal_white_adipose0.75736436
83MP0000313_abnormal_cell_death0.74185658
84MP0000383_abnormal_hair_follicle0.73731011
85MP0000427_abnormal_hair_cycle0.72177379
86MP0004381_abnormal_hair_follicle0.71643740
87MP0003879_abnormal_hair_cell0.71552459
88MP0008569_lethality_at_weaning0.70254941
89MP0001944_abnormal_pancreas_morphology0.70024122
90MP0008469_abnormal_protein_level0.69938932
91MP0004264_abnormal_extraembryonic_tissu0.69236944
92MP0001216_abnormal_epidermal_layer0.68334480
93MP0002998_abnormal_bone_remodeling0.68311852
94MP0002138_abnormal_hepatobiliary_system0.67794522
95MP0010352_gastrointestinal_tract_polyps0.67469230
96MP0002127_abnormal_cardiovascular_syste0.67119039
97MP0008932_abnormal_embryonic_tissue0.66906679
98MP0005310_abnormal_salivary_gland0.66813422
99MP0002009_preneoplasia0.66676130
100MP0002970_abnormal_white_adipose0.65135182
101MP0004185_abnormal_adipocyte_glucose0.64551389
102MP0003252_abnormal_bile_duct0.62928564
103MP0004742_abnormal_vestibular_system0.62155259
104MP0001529_abnormal_vocalization0.62028441
105* MP0002083_premature_death0.61061976
106MP0006292_abnormal_olfactory_placode0.60540205
107MP0010307_abnormal_tumor_latency0.59968659
108MP0005076_abnormal_cell_differentiation0.59742386
109MP0009764_decreased_sensitivity_to0.59134807
110MP0006072_abnormal_retinal_apoptosis0.58786270
111MP0000465_gastrointestinal_hemorrhage0.58709561
112MP0001919_abnormal_reproductive_system0.57628258
113MP0003315_abnormal_perineum_morphology0.56335192
114MP0005367_renal/urinary_system_phenotyp0.55926456
115MP0000516_abnormal_urinary_system0.55926456
116MP0003890_abnormal_embryonic-extraembry0.55693660
117MP0001697_abnormal_embryo_size0.54594128
118MP0001191_abnormal_skin_condition0.54285467
119MP0006035_abnormal_mitochondrial_morpho0.53652145
120MP0005389_reproductive_system_phenotype0.53351225
121MP0003567_abnormal_fetal_cardiomyocyte0.53220394
122MP0003136_yellow_coat_color0.52248105
123MP0002092_abnormal_eye_morphology0.51462451
124MP0009931_abnormal_skin_appearance0.50856853
125MP0004197_abnormal_fetal_growth/weight/0.49489798
126MP0008770_decreased_survivor_rate0.49008599
127MP0003943_abnormal_hepatobiliary_system0.48661674
128* MP0000367_abnormal_coat/_hair0.47749353
129MP0003959_abnormal_lean_body0.47419605
130MP0005621_abnormal_cell_physiology0.47418647
131MP0005365_abnormal_bile_salt0.47362942
132MP0001485_abnormal_pinna_reflex0.46742938
133MP0008775_abnormal_heart_ventricle0.46459119
134MP0003868_abnormal_feces_composition0.46345836
135MP0009115_abnormal_fat_cell0.46272762
136MP0003718_maternal_effect0.44792640
137MP0001784_abnormal_fluid_regulation0.43070337
138MP0002086_abnormal_extraembryonic_tissu0.42661444
139MP0001756_abnormal_urination0.41035211

Predicted human phenotypes

RankGene SetZ-score
1* Abnormality of B cell number (HP:0010975)9.00637667
2* B lymphocytopenia (HP:0010976)9.00637667
3* Thyroiditis (HP:0100646)7.63531873
4* T lymphocytopenia (HP:0005403)7.49767523
5* Abnormality of T cell number (HP:0011839)7.17141513
6* Severe combined immunodeficiency (HP:0004430)6.76028109
7* Hypoplasia of the thymus (HP:0000778)6.67665092
8Agammaglobulinemia (HP:0004432)6.56868923
9* Panhypogammaglobulinemia (HP:0003139)6.49511954
10* Recurrent viral infections (HP:0004429)6.42733757
11* Combined immunodeficiency (HP:0005387)5.81208732
12* Eosinophilia (HP:0001880)5.49303246
13Verrucae (HP:0200043)5.29675208
14Papilloma (HP:0012740)5.29675208
15Cellulitis (HP:0100658)4.86942317
16* Granulocytopenia (HP:0001913)4.49303859
17* Hypoproteinemia (HP:0003075)4.27491417
18* Meningitis (HP:0001287)4.22941149
19* Abnormality of eosinophils (HP:0001879)4.21139339
20* Abnormality of T cells (HP:0002843)4.08151610
21* Recurrent fungal infections (HP:0002841)4.07565157
22* IgG deficiency (HP:0004315)3.74554006
23* Sepsis (HP:0100806)3.59047256
24Abnormality of the fingertips (HP:0001211)3.31309572
25Small epiphyses (HP:0010585)3.29230334
26Acute lymphatic leukemia (HP:0006721)3.29090954
27Osteomyelitis (HP:0002754)3.27487672
28Volvulus (HP:0002580)3.24623569
29Recurrent bronchitis (HP:0002837)3.00031645
30* Leukocytosis (HP:0001974)2.87766030
31Recurrent pneumonia (HP:0006532)2.84898371
32Carpal bone hypoplasia (HP:0001498)2.83654300
33Abnormality of the intervertebral disk (HP:0005108)2.78883931
34* Aplasia/Hypoplasia of the thymus (HP:0010515)2.56325345
35* Erythroderma (HP:0001019)2.53344180
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.51315482
37Recurrent cutaneous fungal infections (HP:0011370)2.44027348
38Chronic mucocutaneous candidiasis (HP:0002728)2.44027348
39Chronic sinusitis (HP:0011109)2.41783330
40* Lymphoma (HP:0002665)2.41523284
41Cutis marmorata (HP:0000965)2.29383594
42Chromsome breakage (HP:0040012)2.28295234
43Prostate neoplasm (HP:0100787)2.26911985
44Autoimmune thrombocytopenia (HP:0001973)2.25866345
45Cellular immunodeficiency (HP:0005374)2.25381928
46Recurrent lower respiratory tract infections (HP:0002783)2.24613265
47IgM deficiency (HP:0002850)2.23388205
48Hypoplasia of the capital femoral epiphysis (HP:0003090)2.21853640
49* Abnormality of the thymus (HP:0000777)2.21530323
50Deep philtrum (HP:0002002)2.20031975
51Colitis (HP:0002583)2.18848283
52Gastrointestinal inflammation (HP:0004386)2.16087725
53Long eyelashes (HP:0000527)2.13814928
54Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12972618
55Skin rash (HP:0000988)2.12854813
56Flattened epiphyses (HP:0003071)2.12223485
57Abnormality of cells of the lymphoid lineage (HP:0012140)2.10330906
58Lymphopenia (HP:0001888)2.07050723
59Recurrent otitis media (HP:0000403)2.06635615
60Inflammation of the large intestine (HP:0002037)2.06400864
61Chronic otitis media (HP:0000389)2.03922097
62Elevated erythrocyte sedimentation rate (HP:0003565)2.03642947
63Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94320266
64Hypoplasia of the pons (HP:0012110)1.91038390
65Vertebral arch anomaly (HP:0008438)1.90717603
66Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.84070339
67Absent epiphyses (HP:0010577)1.84070339
68Encephalitis (HP:0002383)1.83512457
69Abnormality of the prostate (HP:0008775)1.82309835
70Neutropenia (HP:0001875)1.80931901
71Abnormality of the pons (HP:0007361)1.77821857
72Recurrent sinusitis (HP:0011108)1.76796114
73Recurrent skin infections (HP:0001581)1.76744653
74Abnormality of chromosome stability (HP:0003220)1.74822187
75Abnormality of the parathyroid morphology (HP:0011766)1.70439619
76Irregular vertebral endplates (HP:0003301)1.69208582
77Albinism (HP:0001022)1.69197909
78Recurrent bacterial skin infections (HP:0005406)1.68605312
79Abnormality of chromosome segregation (HP:0002916)1.68345021
80Autoimmune hemolytic anemia (HP:0001890)1.66985341
81Myositis (HP:0100614)1.66809551
82Aortic valve stenosis (HP:0001650)1.63917767
83Abnormality of T cell physiology (HP:0011840)1.62867192
84Recurrent abscess formation (HP:0002722)1.61149777
85Prolonged bleeding time (HP:0003010)1.60289610
86Colon cancer (HP:0003003)1.56965689
87Chronic hepatic failure (HP:0100626)1.56669794
88Type 2 muscle fiber atrophy (HP:0003554)1.55792383
89Myelodysplasia (HP:0002863)1.55661158
90Poikiloderma (HP:0001029)1.55660820
91Abnormal hair whorl (HP:0010721)1.54448163
92Limited elbow extension (HP:0001377)1.53782153
93Truncal obesity (HP:0001956)1.53372965
94Increased nuchal translucency (HP:0010880)1.52919316
95Skin ulcer (HP:0200042)1.51916485
96Mitral stenosis (HP:0001718)1.51593518
9711 pairs of ribs (HP:0000878)1.49688421
98Acute myeloid leukemia (HP:0004808)1.49566313
99Patellar aplasia (HP:0006443)1.49544776
100Abnormality of the renal collecting system (HP:0004742)1.49384148
101Mediastinal lymphadenopathy (HP:0100721)1.48877298
102Duplicated collecting system (HP:0000081)1.48322842
103Aplasia/Hypoplasia of the uvula (HP:0010293)1.46930032
104Absent rod-and cone-mediated responses on ERG (HP:0007688)1.46865655
105Vasculitis (HP:0002633)1.46536016
106Bronchitis (HP:0012387)1.45616310
107Neoplasm of the oral cavity (HP:0100649)1.43994000
108Slow-growing hair (HP:0002217)1.43898038
109Abnormality of hair growth rate (HP:0011363)1.43898038
110Abnormality of the vertebral endplates (HP:0005106)1.43648703
111Chronic obstructive pulmonary disease (HP:0006510)1.43630099
112Obstructive lung disease (HP:0006536)1.43630099
113Thrombocytosis (HP:0001894)1.43146481
114Cutaneous melanoma (HP:0012056)1.41801065
115Muscle fiber atrophy (HP:0100295)1.41266916
116External ear malformation (HP:0008572)1.40648570
117Methylmalonic acidemia (HP:0002912)1.37474751
118Meckel diverticulum (HP:0002245)1.35909870
119Intestinal fistula (HP:0100819)1.34000413
120Clubbing of toes (HP:0100760)1.32546474
121Ectopic kidney (HP:0000086)1.31720591
122Abnormal pancreas size (HP:0012094)1.31503381
123Rectal fistula (HP:0100590)1.30247596
124Rectovaginal fistula (HP:0000143)1.30247596
125Dehydration (HP:0001944)1.29697800
126Abnormal foot bone ossification (HP:0010675)1.28686517
127Abnormality of the ileum (HP:0001549)1.28649757
128Abnormality of the preputium (HP:0100587)1.28612975
129Nonimmune hydrops fetalis (HP:0001790)1.26808336
130Abnormality of the carotid arteries (HP:0005344)1.26723924
131Nephroblastoma (Wilms tumor) (HP:0002667)1.26166199
132Small intestinal stenosis (HP:0012848)1.25065028
133Duodenal stenosis (HP:0100867)1.25065028
134Medulloblastoma (HP:0002885)1.21458003
135Abnormality of male internal genitalia (HP:0000022)1.20463661
136Abnormality of endocrine pancreas physiology (HP:0012093)1.16839583
137Abnormality of the pancreatic islet cells (HP:0006476)1.16839583
138Embryonal renal neoplasm (HP:0011794)1.15208891
139Absent thumb (HP:0009777)1.14685104
140Short phalanx of the thumb (HP:0009660)1.12939721
141Impulsivity (HP:0100710)1.12755056
142Constricted visual fields (HP:0001133)1.12712912
143Squamous cell carcinoma (HP:0002860)1.12372930
144* Pruritus (HP:0000989)1.11830406
145Abnormality of the columella (HP:0009929)1.11490394
146Short 1st metacarpal (HP:0010034)1.08706442
147Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.08706442
148Toxemia of pregnancy (HP:0100603)1.08490636
149Neoplasm of the adrenal cortex (HP:0100641)1.08457342
150Aplasia/Hypoplasia involving the musculature (HP:0001460)1.06654460
151Barrel-shaped chest (HP:0001552)1.06203590
152Stenosis of the external auditory canal (HP:0000402)1.05293419
153Neoplasm of the pancreas (HP:0002894)1.04261740

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K105.68807706
2BMPR1B4.56722123
3MET3.51044500
4MAP3K133.11719835
5MAP4K13.02748910
6GRK62.86767812
7EEF2K2.76266933
8TXK2.73421698
9PIK3CG2.61604844
10TGFBR12.54050731
11SYK2.45392227
12YES12.40690476
13TAF12.34120180
14STK42.26081237
15TLK12.07910347
16NEK22.06374118
17VRK22.01893098
18CDC71.95791088
19SIK21.91573912
20RIPK41.90960889
21ZAP701.74575917
22NLK1.74413863
23MST41.68390094
24BTK1.67703228
25CDK41.67384432
26CDK121.66569351
27MAP3K71.62412654
28MAPK71.62067214
29RPS6KB21.60026553
30STK101.59806938
31ITK1.48335249
32MAPK121.44748637
33ERN11.43848186
34EIF2AK31.42091093
35CLK11.41062659
36CDK71.39191482
37SIK31.31603496
38MAPK111.30773689
39TEC1.28962869
40TYK21.28016173
41PIM11.27416818
42MAPK41.26879641
43HCK1.16714643
44CSF1R1.16347624
45SMG11.16085736
46BUB11.15186443
47CDK91.12366501
48MAPK131.11288854
49TYRO31.08770918
50FLT31.07562733
51BRD41.06652235
52FGFR31.05796154
53LCK1.04954935
54ATR1.03006656
55FGFR21.02795301
56LYN0.99809711
57KIT0.98503943
58CAMKK20.96035614
59CDK60.95537179
60CCNB10.91471285
61VRK10.88170367
62FES0.87872340
63WEE10.86571296
64CDK30.84636150
65CSK0.84085651
66JAK30.81376098
67DYRK30.76621640
68HIPK20.74901041
69PRKCQ0.74117976
70TBK10.74018782
71DYRK1B0.73145707
72TNK20.72473393
73NUAK10.72423474
74RPS6KA50.72118352
75PDGFRB0.72031926
76ADRBK20.70124507
77MARK20.69715363
78ZAK0.69157965
79MKNK20.68979664
80RPS6KC10.64599385
81RPS6KL10.64599385
82LRRK20.64063620
83SGK30.63522328
84SRPK10.63377504
85CAMK40.62670114
86AURKB0.62046270
87TNIK0.60492184
88RPS6KA40.60435970
89CHEK10.60400138
90IKBKE0.59709739
91MAP3K140.59629980
92RPS6KA60.59141609
93FGFR40.58711055
94MELK0.58181114
95PKN20.57708541
96CDK80.56903305
97CHEK20.55221920
98MKNK10.54613162
99STK110.53890278
100TRPM70.53836956
101SCYL20.52924331
102SGK20.52753126
103FRK0.52575150
104MAPKAPK50.51485608
105JAK10.50006699
106AURKA0.49258716
107CAMK10.48503822
108RPS6KB10.47636695
109SIK10.46774451
110ATM0.46519516
111MAP2K70.45335551
112MAP2K20.44572664
113JAK20.43799784
114MAPK30.42881531
115DAPK30.42291479
116NTRK20.41401269
117MAPKAPK30.39944606
118GRK10.39755538
119CDK20.39254630
120MAP3K80.39150643
121TESK20.38300890
122DYRK1A0.37911741
123PLK40.37554086
124PLK10.36856679
125BLK0.36684897
126SGK2230.36198280
127SGK4940.36198280
128CSNK1G10.35685220
129DAPK10.33904651
130PRKCH0.33864416
131WNK10.33469370
132PTK60.32257821
133MARK30.31956857
134CSNK1D0.31245480
135INSRR0.29323935
136RET0.28570331
137TTK0.28345066

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary immunodeficiency_Homo sapiens_hsa053407.82802124
2Non-homologous end-joining_Homo sapiens_hsa034506.67299267
3DNA replication_Homo sapiens_hsa030303.25741511
4Caffeine metabolism_Homo sapiens_hsa002322.75870261
5Base excision repair_Homo sapiens_hsa034102.55933473
6Mismatch repair_Homo sapiens_hsa034302.45920241
7B cell receptor signaling pathway_Homo sapiens_hsa046622.32458009
8T cell receptor signaling pathway_Homo sapiens_hsa046602.31655872
9Hematopoietic cell lineage_Homo sapiens_hsa046402.31606123
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.25790686
11Systemic lupus erythematosus_Homo sapiens_hsa053222.01897169
12Cell cycle_Homo sapiens_hsa041101.98606045
13Homologous recombination_Homo sapiens_hsa034401.86777072
14Antigen processing and presentation_Homo sapiens_hsa046121.83229711
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.80587331
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.74163123
17Measles_Homo sapiens_hsa051621.56693608
18Fanconi anemia pathway_Homo sapiens_hsa034601.47562826
19Spliceosome_Homo sapiens_hsa030401.36459356
20Chronic myeloid leukemia_Homo sapiens_hsa052201.35617257
21Acute myeloid leukemia_Homo sapiens_hsa052211.31279669
22Herpes simplex infection_Homo sapiens_hsa051681.29846623
23Viral carcinogenesis_Homo sapiens_hsa052031.26367636
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23316914
25RNA polymerase_Homo sapiens_hsa030201.21999000
26Nucleotide excision repair_Homo sapiens_hsa034201.18652534
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16525999
28Hepatitis B_Homo sapiens_hsa051611.16382306
29Non-small cell lung cancer_Homo sapiens_hsa052231.13857001
30Alcoholism_Homo sapiens_hsa050341.13842918
31Osteoclast differentiation_Homo sapiens_hsa043801.12502872
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11601312
33Colorectal cancer_Homo sapiens_hsa052101.09313849
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04676040
35Sulfur relay system_Homo sapiens_hsa041221.04294797
36Thyroid cancer_Homo sapiens_hsa052161.02170527
37HTLV-I infection_Homo sapiens_hsa051661.00082119
38Leishmaniasis_Homo sapiens_hsa051400.99572941
39Asthma_Homo sapiens_hsa053100.92819435
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90281282
41One carbon pool by folate_Homo sapiens_hsa006700.87617389
42Basal cell carcinoma_Homo sapiens_hsa052170.87573730
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85089765
44Pancreatic cancer_Homo sapiens_hsa052120.81523385
45Chemokine signaling pathway_Homo sapiens_hsa040620.80867440
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80179989
47Autoimmune thyroid disease_Homo sapiens_hsa053200.79605174
48p53 signaling pathway_Homo sapiens_hsa041150.78883002
49Pyrimidine metabolism_Homo sapiens_hsa002400.78182754
50mTOR signaling pathway_Homo sapiens_hsa041500.75605313
51Pentose phosphate pathway_Homo sapiens_hsa000300.75536871
52Prostate cancer_Homo sapiens_hsa052150.74448019
53Endometrial cancer_Homo sapiens_hsa052130.74179352
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73853545
55Graft-versus-host disease_Homo sapiens_hsa053320.73726966
56Lysine degradation_Homo sapiens_hsa003100.73484733
57RNA degradation_Homo sapiens_hsa030180.72762482
58mRNA surveillance pathway_Homo sapiens_hsa030150.72731476
59Epstein-Barr virus infection_Homo sapiens_hsa051690.70000784
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69863528
61* FoxO signaling pathway_Homo sapiens_hsa040680.69778175
62Phototransduction_Homo sapiens_hsa047440.67728194
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65270940
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65051062
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64297021
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.63814457
67Allograft rejection_Homo sapiens_hsa053300.62613025
68Small cell lung cancer_Homo sapiens_hsa052220.61281384
69Influenza A_Homo sapiens_hsa051640.59896406
70Melanoma_Homo sapiens_hsa052180.59445442
71Renal cell carcinoma_Homo sapiens_hsa052110.58743171
72Apoptosis_Homo sapiens_hsa042100.55506250
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54570993
74Oocyte meiosis_Homo sapiens_hsa041140.54060709
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53897830
76Dorso-ventral axis formation_Homo sapiens_hsa043200.49954937
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.49665867
78MicroRNAs in cancer_Homo sapiens_hsa052060.48703963
79Ribosome_Homo sapiens_hsa030100.45905781
80Legionellosis_Homo sapiens_hsa051340.45481652
81Tuberculosis_Homo sapiens_hsa051520.45416938
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41575749
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41191945
84Shigellosis_Homo sapiens_hsa051310.40749950
85RNA transport_Homo sapiens_hsa030130.37793504
86Fatty acid biosynthesis_Homo sapiens_hsa000610.37353080
87Glioma_Homo sapiens_hsa052140.37343468
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37298694
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37236810
90Toxoplasmosis_Homo sapiens_hsa051450.36956147
91Circadian rhythm_Homo sapiens_hsa047100.36546667
92Renin-angiotensin system_Homo sapiens_hsa046140.34894339
93Platelet activation_Homo sapiens_hsa046110.33134655
94Type II diabetes mellitus_Homo sapiens_hsa049300.33053403
95Wnt signaling pathway_Homo sapiens_hsa043100.32431914
96Inositol phosphate metabolism_Homo sapiens_hsa005620.31845135
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31425959
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31328241
99Linoleic acid metabolism_Homo sapiens_hsa005910.29691354
100Purine metabolism_Homo sapiens_hsa002300.29652393
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.29489009
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29408473
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27676816
104Malaria_Homo sapiens_hsa051440.26202436
105TGF-beta signaling pathway_Homo sapiens_hsa043500.25700976
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24963569
107Arachidonic acid metabolism_Homo sapiens_hsa005900.24870335
108Olfactory transduction_Homo sapiens_hsa047400.24689940
109ErbB signaling pathway_Homo sapiens_hsa040120.24350028
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23678102
111African trypanosomiasis_Homo sapiens_hsa051430.21471722
112Taste transduction_Homo sapiens_hsa047420.21160609
113Pathways in cancer_Homo sapiens_hsa052000.20976785
114Oxytocin signaling pathway_Homo sapiens_hsa049210.20604117
115Type I diabetes mellitus_Homo sapiens_hsa049400.20060430
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.18884972
117TNF signaling pathway_Homo sapiens_hsa046680.18342392
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.17514466
119Morphine addiction_Homo sapiens_hsa050320.16726761
120Basal transcription factors_Homo sapiens_hsa030220.16508550
121N-Glycan biosynthesis_Homo sapiens_hsa005100.16274731
122Choline metabolism in cancer_Homo sapiens_hsa052310.16065450
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.15461537
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.14812800
125Melanogenesis_Homo sapiens_hsa049160.14595359
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.13108784
127Regulation of autophagy_Homo sapiens_hsa041400.12745739
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12309195
129Long-term potentiation_Homo sapiens_hsa047200.12150555
130Pertussis_Homo sapiens_hsa051330.12124005
131Insulin resistance_Homo sapiens_hsa049310.10910375
132Hepatitis C_Homo sapiens_hsa051600.10652670
133Viral myocarditis_Homo sapiens_hsa054160.08787930
134Selenocompound metabolism_Homo sapiens_hsa004500.08394673
135Hedgehog signaling pathway_Homo sapiens_hsa043400.08284957
136Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.06164119

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