RAI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located within the Smith-Magenis syndrome region on chromosome 17. It is highly similar to its mouse counterpart and is expressed at high levels mainly in neuronal tissues. The protein encoded by this gene includes a polymorphic polyglutamine tract in the N-terminal domain. Expression of the mouse counterpart in neurons is induced by retinoic acid. This gene is associated with both the severity of the phenotype and the response to medication in schizophrenic patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine dimer repair (GO:0006290)4.74531239
2substrate-independent telencephalic tangential migration (GO:0021826)4.57091728
3substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.57091728
4planar cell polarity pathway involved in neural tube closure (GO:0090179)4.42421703
5embryonic foregut morphogenesis (GO:0048617)4.35034299
6regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.13107491
7negative regulation of cell killing (GO:0031342)3.99317256
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.99317256
9hemidesmosome assembly (GO:0031581)3.89061859
10protein-DNA complex disassembly (GO:0032986)3.79126854
11nucleosome disassembly (GO:0006337)3.79126854
12desmosome organization (GO:0002934)3.72192388
13cell-substrate junction assembly (GO:0007044)3.69344461
14focal adhesion assembly (GO:0048041)3.64543708
15positive regulation of histone deacetylation (GO:0031065)3.62398867
16epithelial cell fate commitment (GO:0072148)3.56569043
17layer formation in cerebral cortex (GO:0021819)3.56266463
18activation of Rac GTPase activity (GO:0032863)3.54307946
19histone H3-K4 trimethylation (GO:0080182)3.53946248
20lens morphogenesis in camera-type eye (GO:0002089)3.43093714
21gastrulation with mouth forming second (GO:0001702)3.41013777
22atrioventricular valve morphogenesis (GO:0003181)3.31348906
23glial cell proliferation (GO:0014009)3.29715610
24dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.24235845
25G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.23314608
26regulation of glucose import in response to insulin stimulus (GO:2001273)3.23138870
27locomotory exploration behavior (GO:0035641)3.22874893
28Golgi transport vesicle coating (GO:0048200)3.22428124
29COPI coating of Golgi vesicle (GO:0048205)3.22428124
30glycine transport (GO:0015816)3.21478904
31negative regulation of erythrocyte differentiation (GO:0045647)3.20383924
32protein localization to endosome (GO:0036010)3.18917817
33negative regulation of fatty acid transport (GO:2000192)3.18203306
34endothelial cell chemotaxis (GO:0035767)3.14704827
35basement membrane organization (GO:0071711)3.13476331
36negative regulation of histone methylation (GO:0031061)3.12987971
37regulation of mammary gland epithelial cell proliferation (GO:0033599)3.08753567
38cell-cell junction maintenance (GO:0045217)3.07635376
39pre-miRNA processing (GO:0031054)3.05278601
40apoptotic process involved in morphogenesis (GO:0060561)3.02202304
41cytoskeletal anchoring at plasma membrane (GO:0007016)3.01474921
42multicellular organismal aging (GO:0010259)2.98268044
43retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.91090444
44Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.90122952
45positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.89566554
46embryonic eye morphogenesis (GO:0048048)2.89561930
47positive regulation of gene expression, epigenetic (GO:0045815)2.88374074
48positive regulation of blood vessel endothelial cell migration (GO:0043536)2.86585437
49peptidyl-lysine dimethylation (GO:0018027)2.86326830
50regulation of fatty acid beta-oxidation (GO:0031998)2.85573039
51protein retention in ER lumen (GO:0006621)2.84124704
52negative regulation of RNA splicing (GO:0033119)2.81685405
53positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.81634534
54regulation of NFAT protein import into nucleus (GO:0051532)2.80221057
55epithelial cell-cell adhesion (GO:0090136)2.79792823
56dendritic spine morphogenesis (GO:0060997)2.79449039
57regulation of establishment of planar polarity (GO:0090175)2.78901203
58maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.78625707
59establishment of nucleus localization (GO:0040023)2.78538917
60sodium ion export (GO:0071436)2.78495724
61syncytium formation (GO:0006949)2.78021492
62regulation of gamma-delta T cell differentiation (GO:0045586)2.77697163
63synaptic vesicle maturation (GO:0016188)2.75305263
64positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.75179039
65cytoplasmic mRNA processing body assembly (GO:0033962)2.74890556
66mitotic sister chromatid cohesion (GO:0007064)2.74707434
67epithelial cell differentiation involved in prostate gland development (GO:0060742)2.74199898
68negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.73395031
69vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.72320649
70negative regulation of telomere maintenance (GO:0032205)2.72085301
71embryonic camera-type eye morphogenesis (GO:0048596)2.71907842
72maternal placenta development (GO:0001893)2.71006112
73lymphangiogenesis (GO:0001946)2.70589598
74stress granule assembly (GO:0034063)2.68667584
75regulation of histone H3-K27 methylation (GO:0061085)2.68061289
76artery development (GO:0060840)2.67721125
77protein targeting to plasma membrane (GO:0072661)2.65799218
78skin morphogenesis (GO:0043589)2.65423726
79eye morphogenesis (GO:0048592)2.63528683
80synaptic vesicle docking involved in exocytosis (GO:0016081)2.62167481
81positive regulation of RNA splicing (GO:0033120)2.61953812
82cell proliferation in forebrain (GO:0021846)2.61498710
83insulin-like growth factor receptor signaling pathway (GO:0048009)2.61280131
84branching involved in mammary gland duct morphogenesis (GO:0060444)2.60262274
85regulation of early endosome to late endosome transport (GO:2000641)2.59299335
86vascular endothelial growth factor signaling pathway (GO:0038084)2.58573506
87glucocorticoid receptor signaling pathway (GO:0042921)2.56947001
88cell migration in hindbrain (GO:0021535)2.56512289
89histone H3-K4 methylation (GO:0051568)2.56195681
90ear development (GO:0043583)2.56169659
91regulation of telomere maintenance (GO:0032204)2.55664749
92mannose metabolic process (GO:0006013)2.54873837
93negative regulation of gene expression, epigenetic (GO:0045814)2.52546295
94regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.51664980
95positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.51036537
96camera-type eye morphogenesis (GO:0048593)2.50613295
97alternative mRNA splicing, via spliceosome (GO:0000380)2.50175555
98establishment of apical/basal cell polarity (GO:0035089)2.50003128
99cellular response to epidermal growth factor stimulus (GO:0071364)2.49674860
100negative regulation of potassium ion transmembrane transport (GO:1901380)2.48965895
101negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.48320904
102cochlea morphogenesis (GO:0090103)2.46764944
103peptidyl-tyrosine autophosphorylation (GO:0038083)2.45753250
104regulation of ARF GTPase activity (GO:0032312)2.44695032
105signal complex assembly (GO:0007172)2.44473584
106regulation of short-term neuronal synaptic plasticity (GO:0048172)2.44411871
107positive regulation of gamma-delta T cell activation (GO:0046645)2.43562460
108regulation of endothelial cell chemotaxis (GO:2001026)2.43042271
109positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.41472859
110peptidyl-lysine trimethylation (GO:0018023)2.41303887
111neural tube development (GO:0021915)2.41193527
112apical protein localization (GO:0045176)2.40064883
113negative regulation of catenin import into nucleus (GO:0035414)2.39941105
114cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.39663385
115osteoblast development (GO:0002076)2.37583234
116negative regulation of viral release from host cell (GO:1902187)2.37457273
117negative regulation of myotube differentiation (GO:0010832)2.37115524
118positive regulation of protein deacetylation (GO:0090312)2.36283426
119positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.35773552
120protein heterotrimerization (GO:0070208)2.35672455
121response to laminar fluid shear stress (GO:0034616)2.35629911
122regulation of apoptotic process involved in morphogenesis (GO:1902337)2.35373850
123cerebellar Purkinje cell differentiation (GO:0021702)2.35364739
124stress fiber assembly (GO:0043149)2.35362142
125regulation of ARF protein signal transduction (GO:0032012)2.35180118
126regulation of glutamate receptor signaling pathway (GO:1900449)2.34931635
127modulation by virus of host morphology or physiology (GO:0019048)2.34825747
128adherens junction organization (GO:0034332)2.34695904
129cell junction maintenance (GO:0034331)2.34228800
130protoporphyrinogen IX biosynthetic process (GO:0006782)2.34134856
131positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.34051154
132negative regulation of cytosolic calcium ion concentration (GO:0051481)2.32982087
133adherens junction assembly (GO:0034333)2.31676642
134heart morphogenesis (GO:0003007)2.31334047
135histone H4-K16 acetylation (GO:0043984)2.30547087
136corticosteroid receptor signaling pathway (GO:0031958)2.30106449
137Peyers patch development (GO:0048541)2.29670680
138mucosal-associated lymphoid tissue development (GO:0048537)2.29670680
139granulocyte differentiation (GO:0030851)2.29522035
140cell volume homeostasis (GO:0006884)2.29341608
141histone H3-K9 demethylation (GO:0033169)2.28342079
142positive regulation of synapse maturation (GO:0090129)2.28120351
143histone H3 deacetylation (GO:0070932)2.27923017
144positive regulation of dendrite morphogenesis (GO:0050775)2.27232056
145head development (GO:0060322)2.26963328
146regulation of gamma-delta T cell activation (GO:0046643)2.26954701
147semaphorin-plexin signaling pathway (GO:0071526)2.26943101
148convergent extension (GO:0060026)2.26920986
149regulation of nucleobase-containing compound transport (GO:0032239)2.26620942
150peptidyl-lysine methylation (GO:0018022)2.26146067
151regulation of histone H3-K4 methylation (GO:0051569)2.26036458
152intracellular estrogen receptor signaling pathway (GO:0030520)2.25680459
153natural killer cell differentiation (GO:0001779)2.25074712
154activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.24949460
155positive regulation of CREB transcription factor activity (GO:0032793)2.24623497
156dosage compensation (GO:0007549)2.24242468
157regulation of water loss via skin (GO:0033561)2.24210917
158negative regulation of chondrocyte differentiation (GO:0032331)2.24078172
159cell communication by electrical coupling (GO:0010644)2.23904256
160chromatin silencing (GO:0006342)2.23428960
161outflow tract septum morphogenesis (GO:0003148)2.22876634
162histone lysine methylation (GO:0034968)2.22260387
163vocalization behavior (GO:0071625)2.21872424
164asymmetric protein localization (GO:0008105)2.21838242
165regulation of DNA endoreduplication (GO:0032875)2.21289827
166negative regulation of cell size (GO:0045792)2.20789624
167activation of MAPKKK activity (GO:0000185)2.20784747
168regulation of RNA export from nucleus (GO:0046831)2.20554462
169positive regulation of Rap GTPase activity (GO:0032854)2.20322191
170lung epithelium development (GO:0060428)2.19694297
171positive regulation of receptor recycling (GO:0001921)2.19504512
172actin filament bundle organization (GO:0061572)2.19085633
173actin filament bundle assembly (GO:0051017)2.19085633
174positive T cell selection (GO:0043368)2.19062394
175cardiac myofibril assembly (GO:0055003)2.18814383
176regulation of synapse structural plasticity (GO:0051823)2.18699571
177regulation of histone deacetylation (GO:0031063)2.18449515
178mitotic G1 DNA damage checkpoint (GO:0031571)2.18247385
179RNA stabilization (GO:0043489)2.16216252
180mRNA stabilization (GO:0048255)2.16216252
181negative regulation of circadian rhythm (GO:0042754)2.16002603
182cell-substrate adherens junction assembly (GO:0007045)2.15695547

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.30442697
2* MYC_22102868_ChIP-Seq_BL_Human4.07959849
3EZH2_22144423_ChIP-Seq_EOC_Human3.28939048
4VDR_21846776_ChIP-Seq_THP-1_Human3.13890502
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.08812296
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.08327726
7* KDM2B_26808549_Chip-Seq_SUP-B15_Human3.03643455
8* KDM2B_26808549_Chip-Seq_DND41_Human2.98107671
9TCF7_22412390_ChIP-Seq_EML_Mouse2.85694778
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76218895
11* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.69237307
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.61303075
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.60213373
14* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.58150388
15* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.50836245
16* KDM2B_26808549_Chip-Seq_JURKAT_Human2.42030828
17* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.37190452
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25962708
19* KDM2B_26808549_Chip-Seq_K562_Human2.25297606
20* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.23355848
21DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.22079933
22* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.21792638
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.16947374
24ZNF263_19887448_ChIP-Seq_K562_Human2.16930302
25SCL_19346495_ChIP-Seq_HPC-7_Human2.14439690
26* RARB_27405468_Chip-Seq_BRAIN_Mouse2.13845070
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.09053114
28DROSHA_22980978_ChIP-Seq_HELA_Human2.05485056
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.00500946
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.94731297
31UTX_26944678_Chip-Seq_JUKART_Human1.94095817
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.89896298
33LXR_22292898_ChIP-Seq_THP-1_Human1.84852231
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.83911441
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81145874
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.81004471
37E2F7_22180533_ChIP-Seq_HELA_Human1.78722859
38EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.75691538
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75047079
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74676310
41VDR_24763502_ChIP-Seq_THP-1_Human1.73169225
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69846298
43* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.67323071
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.65203456
45MAF_26560356_Chip-Seq_TH1_Human1.62191110
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.62125869
47* SMC4_20622854_ChIP-Seq_HELA_Human1.58754550
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54367972
49GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52867862
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.52662523
51KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49236730
52* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49044089
53* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49044089
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.47010838
55* RNF2_27304074_Chip-Seq_ESCs_Mouse1.42415853
56CLOCK_20551151_ChIP-Seq_293T_Human1.40507005
57CREB1_26743006_Chip-Seq_LNCaP_Human1.38622885
58* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36811777
59* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36663483
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36457491
61* EZH2_27294783_Chip-Seq_ESCs_Mouse1.36004550
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35673457
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35447033
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34569065
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.33608534
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31765909
67SPI1_23127762_ChIP-Seq_K562_Human1.31193216
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.31070247
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31024882
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.29236076
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28835158
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26175086
73* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26070063
74CIITA_25753668_ChIP-Seq_RAJI_Human1.26062683
75GATA1_19941826_ChIP-Seq_K562_Human1.26008666
76UBF1/2_26484160_Chip-Seq_HMECs_Human1.24546416
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24375251
78OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.24202882
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23566260
80ISL1_27105846_Chip-Seq_CPCs_Mouse1.23369620
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23360555
82* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22947668
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22240187
84RING1B_27294783_Chip-Seq_NPCs_Mouse1.21708485
85CTCF_27219007_Chip-Seq_Bcells_Human1.21568917
86NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21372431
87TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.20663756
88ATF3_27146783_Chip-Seq_COLON_Human1.20621435
89TP53_22127205_ChIP-Seq_IMR90_Human1.20532826
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.20225354
91* RACK7_27058665_Chip-Seq_MCF-7_Human1.18741971
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17756901
93* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17086581
94SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16986712
95* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16101635
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15670555
97SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15491721
98GATA1_19941827_ChIP-Seq_MEL_Mouse1.15336259
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15259612
100PKCTHETA_26484144_Chip-Seq_BREAST_Human1.14571243
101* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13578178
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12484175
103* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12194191
104TP53_23651856_ChIP-Seq_MEFs_Mouse1.11688942
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11445216
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09518699
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09298439
108TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09288032
109NCOR1_26117541_ChIP-Seq_K562_Human1.08837451
110* TET1_21490601_ChIP-Seq_MESCs_Mouse1.08803973
111* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07490945
112ESR1_20079471_ChIP-ChIP_T-47D_Human1.07382378
113SA1_27219007_Chip-Seq_ERYTHROID_Human1.07235062
114* TP63_22573176_ChIP-Seq_HFKS_Human1.06399770
115* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06122015
116TP63_19390658_ChIP-ChIP_HaCaT_Human1.04980461
117NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04559379
118* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04007528
119TP53_20018659_ChIP-ChIP_R1E_Mouse1.03858001
120ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03766210
121TBX20_22328084_ChIP-Seq_HEART_Mouse1.03578301
122TBX20_22080862_ChIP-Seq_HEART_Mouse1.03578301
123* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02190313
124ELF1_20517297_ChIP-Seq_JURKAT_Human1.01700427
125PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01213141
126* MAF_26560356_Chip-Seq_TH2_Human0.99819073
127ERG_21242973_ChIP-ChIP_JURKAT_Human0.99350447
128FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99173541
129ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98956514
130SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98861400
131RUNX_20019798_ChIP-Seq_JUKART_Human0.96217010
132* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95650682
133* P68_20966046_ChIP-Seq_HELA_Human0.94707185
134SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94530553
135KLF5_25053715_ChIP-Seq_YYC3_Human0.94485814
136* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94179359
137FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93752731
138SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92787131
139STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91936176
140RUNX1_27514584_Chip-Seq_MCF-7_Human0.91196640
141CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90430043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.65692506
2MP0008438_abnormal_cutaneous_collagen3.00045419
3MP0008961_abnormal_basal_metabolism2.99228285
4MP0000566_synostosis2.67654009
5MP0010030_abnormal_orbit_morphology2.43888500
6MP0003566_abnormal_cell_adhesion2.43157806
7MP0005257_abnormal_intraocular_pressure2.41017235
8MP0010234_abnormal_vibrissa_follicle2.22616967
9MP0002877_abnormal_melanocyte_morpholog2.21132963
10MP0005076_abnormal_cell_differentiation2.17020320
11MP0009278_abnormal_bone_marrow2.14234540
12MP0003122_maternal_imprinting2.10814291
13MP0000579_abnormal_nail_morphology2.01180650
14MP0004808_abnormal_hematopoietic_stem2.00829749
15MP0002396_abnormal_hematopoietic_system1.96406838
16MP0000569_abnormal_digit_pigmentation1.95794539
17* MP0002249_abnormal_larynx_morphology1.90150073
18MP0005367_renal/urinary_system_phenotyp1.87188249
19MP0000516_abnormal_urinary_system1.87188249
20MP0008569_lethality_at_weaning1.84545776
21MP0003300_gastrointestinal_ulcer1.84122959
22MP0003635_abnormal_synaptic_transmissio1.83261687
23MP0004272_abnormal_basement_membrane1.81730925
24MP0003279_aneurysm1.81452803
25MP0000537_abnormal_urethra_morphology1.77243825
26MP0000678_abnormal_parathyroid_gland1.76007613
27MP0000751_myopathy1.69426131
28MP0009780_abnormal_chondrocyte_physiolo1.67218067
29MP0000013_abnormal_adipose_tissue1.66801354
30MP0005451_abnormal_body_composition1.66073810
31MP0001958_emphysema1.60221549
32MP0003453_abnormal_keratinocyte_physiol1.60081365
33MP0003303_peritoneal_inflammation1.56537197
34MP0004233_abnormal_muscle_weight1.56304690
35MP0004381_abnormal_hair_follicle1.55991888
36MP0002060_abnormal_skin_morphology1.55908315
37MP0005275_abnormal_skin_tensile1.52301613
38MP0001849_ear_inflammation1.52301582
39MP0005171_absent_coat_pigmentation1.52064838
40MP0004133_heterotaxia1.50380720
41MP0004142_abnormal_muscle_tone1.49135000
42MP0000003_abnormal_adipose_tissue1.48886961
43MP0008770_decreased_survivor_rate1.45813774
44MP0004885_abnormal_endolymph1.44908763
45MP0004510_myositis1.42209682
46MP0002796_impaired_skin_barrier1.39393312
47MP0003385_abnormal_body_wall1.36925691
48MP0008007_abnormal_cellular_replicative1.36693569
49MP0009053_abnormal_anal_canal1.33700840
50MP0000467_abnormal_esophagus_morphology1.33467856
51MP0004811_abnormal_neuron_physiology1.32648989
52MP0005503_abnormal_tendon_morphology1.32271698
53MP0004197_abnormal_fetal_growth/weight/1.32255516
54MP0005623_abnormal_meninges_morphology1.32102538
55MP0002098_abnormal_vibrissa_morphology1.31215445
56MP0003705_abnormal_hypodermis_morpholog1.30996328
57MP0004185_abnormal_adipocyte_glucose1.29721426
58* MP0002063_abnormal_learning/memory/cond1.27795689
59MP0000703_abnormal_thymus_morphology1.26591367
60MP0003942_abnormal_urinary_system1.26559056
61MP0009384_cardiac_valve_regurgitation1.25078043
62MP0010368_abnormal_lymphatic_system1.23877450
63MP0002234_abnormal_pharynx_morphology1.23866435
64MP0000733_abnormal_muscle_development1.23534601
65MP0003115_abnormal_respiratory_system1.22892918
66MP0004043_abnormal_pH_regulation1.22145289
67MP0000462_abnormal_digestive_system1.18538452
68MP0006138_congestive_heart_failure1.17774708
69MP0002909_abnormal_adrenal_gland1.17033770
70MP0009703_decreased_birth_body1.16297518
71MP0003121_genomic_imprinting1.15615380
72MP0005058_abnormal_lysosome_morphology1.14011170
73MP0003283_abnormal_digestive_organ1.13858639
74MP0002089_abnormal_postnatal_growth/wei1.13643145
75MP0003172_abnormal_lysosome_physiology1.13491762
76MP0000767_abnormal_smooth_muscle1.12599843
77MP0004858_abnormal_nervous_system1.12205803
78MP0000762_abnormal_tongue_morphology1.11699998
79MP0002896_abnormal_bone_mineralization1.10734569
80MP0002184_abnormal_innervation1.10431390
81MP0005501_abnormal_skin_physiology1.09313188
82MP0005409_darkened_coat_color1.07776117
83MP0004264_abnormal_extraembryonic_tissu1.07646434
84MP0003045_fibrosis1.07015808
85MP0003935_abnormal_craniofacial_develop1.06370859
86MP0005023_abnormal_wound_healing1.05377791
87MP0005508_abnormal_skeleton_morphology1.05317667
88MP0009745_abnormal_behavioral_response1.04180902
89MP0003861_abnormal_nervous_system1.03383252
90MP0008260_abnormal_autophagy1.03242793
91MP0002108_abnormal_muscle_morphology1.02888000
92MP0003567_abnormal_fetal_cardiomyocyte1.01570119
93MP0002084_abnormal_developmental_patter1.01505632
94MP0005670_abnormal_white_adipose1.01140416
95MP0005397_hematopoietic_system_phenotyp1.00962716
96MP0001545_abnormal_hematopoietic_system1.00962716
97MP0010630_abnormal_cardiac_muscle1.00759694
98* MP0002116_abnormal_craniofacial_bone1.00537787
99MP0005666_abnormal_adipose_tissue1.00353657
100MP0002925_abnormal_cardiovascular_devel0.99703741
101MP0003787_abnormal_imprinting0.97747494
102MP0000955_abnormal_spinal_cord0.97223242
103MP0000428_abnormal_craniofacial_morphol0.96105902
104MP0002557_abnormal_social/conspecific_i0.96076343
105MP0004145_abnormal_muscle_electrophysio0.95517283
106MP0005621_abnormal_cell_physiology0.94765965
107MP0003329_amyloid_beta_deposits0.94662962
108MP0000681_abnormal_thyroid_gland0.91801128
109MP0003890_abnormal_embryonic-extraembry0.90519129
110MP0001348_abnormal_lacrimal_gland0.90186960
111MP0002009_preneoplasia0.90164101
112MP0005174_abnormal_tail_pigmentation0.88871502
113MP0000266_abnormal_heart_morphology0.88803250
114MP0009046_muscle_twitch0.88505436
115MP0004084_abnormal_cardiac_muscle0.88025009
116MP0004087_abnormal_muscle_fiber0.87594769
117MP0002398_abnormal_bone_marrow0.87569214
118MP0004270_analgesia0.87531653
119MP0005375_adipose_tissue_phenotype0.87048082
120* MP0002064_seizures0.86931684
121MP0002152_abnormal_brain_morphology0.86743981
122MP0004130_abnormal_muscle_cell0.86309305
123MP0004085_abnormal_heartbeat0.86255704
124MP0000759_abnormal_skeletal_muscle0.85268580
125MP0009672_abnormal_birth_weight0.85049475
126MP0001346_abnormal_lacrimal_gland0.83970050
127MP0003763_abnormal_thymus_physiology0.83692798
128MP0000778_abnormal_nervous_system0.83028452
129MP0001216_abnormal_epidermal_layer0.82983269
130MP0006054_spinal_hemorrhage0.82543283
131MP0005187_abnormal_penis_morphology0.81753479
132MP0010769_abnormal_survival0.81539375
133MP0008775_abnormal_heart_ventricle0.81188238
134MP0003111_abnormal_nucleus_morphology0.78978078
135MP0001784_abnormal_fluid_regulation0.78348685
136MP0001486_abnormal_startle_reflex0.78225308
137MP0003091_abnormal_cell_migration0.77894252
138MP0003634_abnormal_glial_cell0.77506874
139MP0009931_abnormal_skin_appearance0.77410991
140* MP0002082_postnatal_lethality0.77127833
141* MP0010770_preweaning_lethality0.77127833
142MP0010768_mortality/aging0.77089060
143* MP0000432_abnormal_head_morphology0.75873788
144MP0003984_embryonic_growth_retardation0.75689426
145MP0001270_distended_abdomen0.75252010
146* MP0002114_abnormal_axial_skeleton0.75035265
147MP0002081_perinatal_lethality0.74351774
148MP0004947_skin_inflammation0.74334296
149MP0002088_abnormal_embryonic_growth/wei0.74136859
150MP0000534_abnormal_ureter_morphology0.73716022
151MP0002106_abnormal_muscle_physiology0.73609319
152MP0003119_abnormal_digestive_system0.73593249
153MP0000377_abnormal_hair_follicle0.73583967
154MP0001915_intracranial_hemorrhage0.73539034
155* MP0002932_abnormal_joint_morphology0.73405518
156MP0010352_gastrointestinal_tract_polyps0.73063520
157MP0002075_abnormal_coat/hair_pigmentati0.72769021
158MP0010771_integument_phenotype0.72005565
159MP0004782_abnormal_surfactant_physiolog0.71059625
160MP0010678_abnormal_skin_adnexa0.69566975
161MP0002086_abnormal_extraembryonic_tissu0.68689443

Predicted human phenotypes

RankGene SetZ-score
1Failure to thrive in infancy (HP:0001531)4.08387758
2* Hyperacusis (HP:0010780)3.92951200
3Obstructive sleep apnea (HP:0002870)3.91848981
4Bilateral microphthalmos (HP:0007633)3.65810554
5Large eyes (HP:0001090)3.34188417
6Abnormality of the aortic arch (HP:0012303)3.31071752
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.30131125
8Short 4th metacarpal (HP:0010044)3.30131125
9Insomnia (HP:0100785)3.27361306
10Abnormality of the fingertips (HP:0001211)3.26593415
11Ulnar bowing (HP:0003031)3.24297498
12Premature rupture of membranes (HP:0001788)3.13885532
13Dislocated radial head (HP:0003083)3.02034676
14Overlapping toe (HP:0001845)2.96958374
15Abnormality of the radial head (HP:0003995)2.94938689
16Renal duplication (HP:0000075)2.86661898
17Pointed chin (HP:0000307)2.83716313
18Elfin facies (HP:0004428)2.83472807
19Prominent metopic ridge (HP:0005487)2.80309649
20Renovascular hypertension (HP:0100817)2.73160507
21Limb dystonia (HP:0002451)2.72134120
22Abnormality of the metopic suture (HP:0005556)2.69294096
23Atrophic scars (HP:0001075)2.69086476
24Fragile skin (HP:0001030)2.63902265
25Macroorchidism (HP:0000053)2.63191955
26Overriding aorta (HP:0002623)2.62813110
27Long eyelashes (HP:0000527)2.61143203
28Cervical subluxation (HP:0003308)2.58392622
29Broad alveolar ridges (HP:0000187)2.49397444
30* Broad face (HP:0000283)2.48723455
31Abnormality of the 4th metacarpal (HP:0010012)2.45540429
32Flat acetabular roof (HP:0003180)2.45074967
33Abnormality of the distal phalanx of the thumb (HP:0009617)2.44779979
34Obsessive-compulsive behavior (HP:0000722)2.44525065
35Shallow orbits (HP:0000586)2.44143148
36Neoplasm of the heart (HP:0100544)2.39892041
37Arterial tortuosity (HP:0005116)2.39060998
38Increased nuchal translucency (HP:0010880)2.33686635
39Thin bony cortex (HP:0002753)2.31739510
40Cerebral aneurysm (HP:0004944)2.31128556
41Advanced eruption of teeth (HP:0006288)2.28175079
42Flat cornea (HP:0007720)2.27684339
43Bowel diverticulosis (HP:0005222)2.27331831
44Panhypogammaglobulinemia (HP:0003139)2.26187624
45Vascular tortuosity (HP:0004948)2.22144687
46Natal tooth (HP:0000695)2.22144532
47Bronchomalacia (HP:0002780)2.21663196
48Asymmetry of the thorax (HP:0001555)2.19867833
49Increased density of long bones (HP:0006392)2.18498328
50Sparse lateral eyebrow (HP:0005338)2.17005775
51Supernumerary ribs (HP:0005815)2.15794139
52Truncus arteriosus (HP:0001660)2.15582027
53Annular pancreas (HP:0001734)2.14228051
54Volvulus (HP:0002580)2.12805051
55Vertebral arch anomaly (HP:0008438)2.12257698
56Aneurysm (HP:0002617)2.11879903
57Abnormality of the humeroradial joint (HP:0100744)2.10885818
58Short nail (HP:0001799)2.09630417
59Abnormality of the lower motor neuron (HP:0002366)2.08075730
60Mildly elevated creatine phosphokinase (HP:0008180)2.06631667
61Wormian bones (HP:0002645)2.05739774
62Increased connective tissue (HP:0009025)2.05565403
63Urethral obstruction (HP:0000796)2.04890040
64Enlarged penis (HP:0000040)2.02684200
65Narrow palate (HP:0000189)2.01527828
66Broad metatarsal (HP:0001783)2.00399390
67Neonatal short-limb short stature (HP:0008921)2.00361609
68Mitral regurgitation (HP:0001653)1.99783438
69Abnormality of the intervertebral disk (HP:0005108)1.99331981
70Joint contractures involving the joints of the feet (HP:0100492)1.97888619
71Flexion contracture of toe (HP:0005830)1.97888619
72Thick eyebrow (HP:0000574)1.97768199
73Joint laxity (HP:0001388)1.96043180
74Adducted thumb (HP:0001181)1.95747215
75Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.95340642
76Sacral dimple (HP:0000960)1.94180017
77Aortic aneurysm (HP:0004942)1.93247889
78Hypoventilation (HP:0002791)1.92560438
79Bladder diverticulum (HP:0000015)1.92546261
80Cutis marmorata (HP:0000965)1.92349873
81Blue sclerae (HP:0000592)1.91857736
82Germ cell neoplasia (HP:0100728)1.90508897
83Premature skin wrinkling (HP:0100678)1.90429224
84Lower limb amyotrophy (HP:0007210)1.90111823
85Spinal cord lesions (HP:0100561)1.89380971
86Syringomyelia (HP:0003396)1.89380971
87Spinal rigidity (HP:0003306)1.89145085
88Bowed forearm bones (HP:0003956)1.88633363
89Bowing of the arm (HP:0006488)1.88633363
90Achilles tendon contracture (HP:0001771)1.87822180
91Genu recurvatum (HP:0002816)1.87173718
92Ankyloglossia (HP:0010296)1.85423207
93Low anterior hairline (HP:0000294)1.85149390
94Aortic dissection (HP:0002647)1.84146508
95Stridor (HP:0010307)1.83247547
96Slender long bone (HP:0003100)1.83040734
97Supernumerary bones of the axial skeleton (HP:0009144)1.82831028
98Abnormality of the distal phalanges of the toes (HP:0010182)1.82259730
99Dysmetric saccades (HP:0000641)1.82217127
100Supranuclear gaze palsy (HP:0000605)1.80817265
101Bicuspid aortic valve (HP:0001647)1.80416901
102Lip pit (HP:0100267)1.80265670
103Lymphangioma (HP:0100764)1.79918914
104J-shaped sella turcica (HP:0002680)1.78124921
105Acute lymphatic leukemia (HP:0006721)1.77955023
106Trigonocephaly (HP:0000243)1.77680799
107Laryngomalacia (HP:0001601)1.77627219
108Biconcave vertebral bodies (HP:0004586)1.77169006
109Hand muscle atrophy (HP:0009130)1.76975986
110Abnormality of the phalanges of the hallux (HP:0010057)1.76300144
111Distal lower limb muscle weakness (HP:0009053)1.76039208
112Turricephaly (HP:0000262)1.75532514
113Tapered finger (HP:0001182)1.75350653
114Thin ribs (HP:0000883)1.74179761
115Abnormality of oral frenula (HP:0000190)1.73481729
116Tetraplegia (HP:0002445)1.72753067
117Protrusio acetabuli (HP:0003179)1.72576867
118* Short philtrum (HP:0000322)1.71934471
119Skin tags (HP:0010609)1.70846657
120Distal upper limb amyotrophy (HP:0007149)1.70499878
121Upper limb amyotrophy (HP:0009129)1.70499878
122Abnormality of dentin (HP:0010299)1.69733531
123Patellar dislocation (HP:0002999)1.69097917
124Milia (HP:0001056)1.68862355
125Arnold-Chiari malformation (HP:0002308)1.68789661
126Spina bifida occulta (HP:0003298)1.67940481
127Abnormality of the heme biosynthetic pathway (HP:0010472)1.66172218
128Protruding ear (HP:0000411)1.65503437
129Difficulty climbing stairs (HP:0003551)1.64611870
130Spinal cord compression (HP:0002176)1.64566529
131Abnormality of the thoracic spine (HP:0100711)1.63874074
132Focal seizures (HP:0007359)1.63832168
133Cellulitis (HP:0100658)1.62951997
134Hemorrhage of the eye (HP:0011885)1.62831560
135Abnormality of the parietal bone (HP:0002696)1.62307924
136* Attention deficit hyperactivity disorder (HP:0007018)1.61883975
137Smooth philtrum (HP:0000319)1.61492852
138* Precocious puberty (HP:0000826)1.60338283
139Wide anterior fontanel (HP:0000260)1.60149489
140Abnormality of the Achilles tendon (HP:0005109)1.60113132
141Abnormality of the left ventricular outflow tract (HP:0011103)1.59801838
142Subaortic stenosis (HP:0001682)1.59801838
143Abnormal ossification of hand bones (HP:0005921)1.59562986
144Mask-like facies (HP:0000298)1.59225836
145Long palpebral fissure (HP:0000637)1.59167515
146Deviation of the hallux (HP:0010051)1.59125452
147Cerebral inclusion bodies (HP:0100314)1.59112160
148Hyperthyroidism (HP:0000836)1.59090803
149Ankle contracture (HP:0006466)1.58874090
150Distal lower limb amyotrophy (HP:0008944)1.58824869
151Abnormality of B cell number (HP:0010975)1.58542287
152B lymphocytopenia (HP:0010976)1.58542287
153Exostoses (HP:0100777)1.58021798
154Heterotopia (HP:0002282)1.57972062
155Mitral valve prolapse (HP:0001634)1.57804153
156Hemiplegia (HP:0002301)1.57763288
157Spondylolisthesis (HP:0003302)1.56538890
158Vertebral compression fractures (HP:0002953)1.56285944
159Depression (HP:0000716)1.56147103
160Hallux valgus (HP:0001822)1.56029773
161Disproportionate tall stature (HP:0001519)1.55923033
162Genetic anticipation (HP:0003743)1.55656254
163Elbow flexion contracture (HP:0002987)1.55153572
164Abnormality of the diencephalon (HP:0010662)1.55041001
165Abnormal number of erythroid precursors (HP:0012131)1.55031425
166Hypopigmentation of the fundus (HP:0007894)1.53864822
167Increased variability in muscle fiber diameter (HP:0003557)1.53061996

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.56654639
2TRIB34.27483784
3EEF2K3.81700322
4SIK23.31017595
5PKN23.28592003
6SMG13.18904611
7EPHA22.72212312
8ICK2.44047600
9MST1R2.20984455
10PTK61.80174796
11IRAK31.78638786
12CDK121.75989533
13CAMK1G1.57468462
14PDGFRA1.55912736
15TAOK11.51629297
16MAP3K71.48793585
17MARK21.46542876
18SIK11.44077675
19TTN1.41474796
20NTRK11.40278896
21ALK1.39961477
22MAP3K91.38055502
23BRD41.35943660
24UHMK11.35560288
25PRKD21.33018369
26RIPK11.31542970
27TYRO31.27686048
28LATS21.27539842
29LRRK21.25193280
30MAP4K11.21504154
31CAMKK11.19664676
32MTOR1.19270218
33PRPF4B1.16888143
34MAP3K41.16349641
35DMPK1.15831834
36MET1.13910951
37NTRK21.13529810
38RET1.06422322
39MARK11.06170337
40LMTK21.05082507
41KSR11.03813577
42CAMK1D1.00759813
43PAK60.98910970
44NTRK30.98060007
45ERN10.96828195
46PRKCH0.96220816
47CLK10.94644196
48CAMK10.93117761
49PDGFRB0.92872243
50EPHB20.91542490
51MAPKAPK30.91437806
52EPHB10.90866922
53PAK20.88439656
54PRKD30.86759430
55FES0.86517682
56CDC42BPA0.85075045
57BMX0.84419402
58STK380.84171151
59SGK30.82570173
60MAP3K60.81996823
61FGFR10.78979864
62PDPK10.77421170
63MAP3K20.76827323
64PTK20.76005636
65MINK10.75311266
66MAP3K30.74901041
67MAPK150.72176205
68CDK70.71977675
69NEK20.71772304
70RPS6KC10.71445316
71RPS6KL10.71445316
72CDK50.70153743
73PAK40.69630400
74JAK30.69054487
75HIPK20.68889771
76BTK0.68121561
77MAPK110.67518981
78HCK0.66666079
79CSF1R0.65936200
80GRK60.65441635
81CAMK40.64445599
82CDK40.64400812
83AKT30.63500698
84DDR20.62903175
85FGFR20.62142982
86DAPK20.61512469
87RPS6KB20.61009379
88ILK0.60837674
89SYK0.60716115
90TESK10.60222682
91CDK60.59724684
92DYRK1B0.58572835
93TNK20.58522402
94MAP3K130.57548031
95MAP2K30.55581133
96MAP2K20.54976831
97CDK90.54433202
98FYN0.53981222
99SCYL20.53525413
100RPS6KA60.53107177
101LATS10.53059476
102ERBB20.52422768
103IRAK20.52310140
104RPS6KA20.52238852
105KSR20.51756719
106CDK80.51733457
107MKNK20.50168144
108STK110.50131688
109PRKD10.48953501
110AKT20.48828659
111MAPK80.48525560
112FGFR30.48344936
113WNK10.47515586
114TGFBR10.47325701
115TRPM70.47123183
116KIT0.45163822
117SIK30.44952332
118CHUK0.44915679
119PTK2B0.44312398
120MELK0.44085177
121MAPK90.43754902
122MAP3K110.43610140
123RPS6KA10.42832363
124RIPK40.41484457
125SRC0.41302276
126MAPK100.41112451
127MAP3K10.40922330
128EPHA40.40609329
129PRKAA10.40181951
130CDK190.39407698
131FGFR40.38079301
132ZAP700.38046101
133CDC70.38028855
134CSNK1A1L0.37038509
135MAPK120.36906918
136DAPK30.36590919
137PDK10.36570682
138CDK150.35712741
139CDK11A0.35412107
140TAOK20.33765385
141FER0.33315678
142PIM20.31943094
143ARAF0.27094353

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052201.71515330
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.63413581
3ECM-receptor interaction_Homo sapiens_hsa045121.60547064
4B cell receptor signaling pathway_Homo sapiens_hsa046621.56552117
5Bladder cancer_Homo sapiens_hsa052191.53597660
6Neurotrophin signaling pathway_Homo sapiens_hsa047221.47967416
7Glioma_Homo sapiens_hsa052141.47582825
8Long-term potentiation_Homo sapiens_hsa047201.42355874
9Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41775483
10Non-small cell lung cancer_Homo sapiens_hsa052231.39289997
11Circadian entrainment_Homo sapiens_hsa047131.37811932
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37390753
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36174158
14Adherens junction_Homo sapiens_hsa045201.34428773
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33454505
16VEGF signaling pathway_Homo sapiens_hsa043701.33119700
17Primary immunodeficiency_Homo sapiens_hsa053401.29295796
18ErbB signaling pathway_Homo sapiens_hsa040121.28075019
19mTOR signaling pathway_Homo sapiens_hsa041501.27565418
20T cell receptor signaling pathway_Homo sapiens_hsa046601.25400444
21Type II diabetes mellitus_Homo sapiens_hsa049301.25392221
22Endometrial cancer_Homo sapiens_hsa052131.25352685
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25200199
24Morphine addiction_Homo sapiens_hsa050321.25064271
25Colorectal cancer_Homo sapiens_hsa052101.23960863
26Dopaminergic synapse_Homo sapiens_hsa047281.22894520
27Prostate cancer_Homo sapiens_hsa052151.22702386
28Thyroid hormone signaling pathway_Homo sapiens_hsa049191.21777109
29Oxytocin signaling pathway_Homo sapiens_hsa049211.21038794
30Lysine degradation_Homo sapiens_hsa003101.20724534
31Olfactory transduction_Homo sapiens_hsa047401.20154354
32Acute myeloid leukemia_Homo sapiens_hsa052211.19816022
33Notch signaling pathway_Homo sapiens_hsa043301.19326010
34Cholinergic synapse_Homo sapiens_hsa047251.19174364
35Nicotine addiction_Homo sapiens_hsa050331.17962301
36Proteoglycans in cancer_Homo sapiens_hsa052051.17763658
37Glutamatergic synapse_Homo sapiens_hsa047241.17620365
38Gastric acid secretion_Homo sapiens_hsa049711.17242524
39Estrogen signaling pathway_Homo sapiens_hsa049151.16974778
40AMPK signaling pathway_Homo sapiens_hsa041521.16758421
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.16595087
42GnRH signaling pathway_Homo sapiens_hsa049121.16334143
43Axon guidance_Homo sapiens_hsa043601.14421795
44Gap junction_Homo sapiens_hsa045401.13678322
45Platelet activation_Homo sapiens_hsa046111.12325613
46Dilated cardiomyopathy_Homo sapiens_hsa054141.11451055
47Other glycan degradation_Homo sapiens_hsa005111.10987157
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10981407
49Basal cell carcinoma_Homo sapiens_hsa052171.09868313
50Inositol phosphate metabolism_Homo sapiens_hsa005621.09006344
51GABAergic synapse_Homo sapiens_hsa047271.08146320
52Salivary secretion_Homo sapiens_hsa049701.07322817
53Melanogenesis_Homo sapiens_hsa049161.05353290
54MicroRNAs in cancer_Homo sapiens_hsa052061.04056770
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02682703
56Amphetamine addiction_Homo sapiens_hsa050311.02137552
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01660952
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00539540
59Phospholipase D signaling pathway_Homo sapiens_hsa040721.00171019
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99073629
61Cocaine addiction_Homo sapiens_hsa050300.98048652
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97997857
63Renin secretion_Homo sapiens_hsa049240.97996953
64Focal adhesion_Homo sapiens_hsa045100.97856505
65Prion diseases_Homo sapiens_hsa050200.97432390
66Amoebiasis_Homo sapiens_hsa051460.97183595
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97176534
68Wnt signaling pathway_Homo sapiens_hsa043100.96395008
69Pancreatic cancer_Homo sapiens_hsa052120.95129255
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94792034
71Insulin secretion_Homo sapiens_hsa049110.94185031
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93727267
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92222925
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.91105979
75Rap1 signaling pathway_Homo sapiens_hsa040150.91032518
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88763889
77Insulin signaling pathway_Homo sapiens_hsa049100.88683625
78Renal cell carcinoma_Homo sapiens_hsa052110.88607108
79Prolactin signaling pathway_Homo sapiens_hsa049170.88558040
80MAPK signaling pathway_Homo sapiens_hsa040100.88342782
81Small cell lung cancer_Homo sapiens_hsa052220.88316138
82cAMP signaling pathway_Homo sapiens_hsa040240.87957996
83Choline metabolism in cancer_Homo sapiens_hsa052310.86441223
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85659260
85Long-term depression_Homo sapiens_hsa047300.85279041
86HTLV-I infection_Homo sapiens_hsa051660.85063884
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84927617
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84726632
89Insulin resistance_Homo sapiens_hsa049310.84465974
90Dorso-ventral axis formation_Homo sapiens_hsa043200.84340234
91Viral myocarditis_Homo sapiens_hsa054160.83811044
92Hedgehog signaling pathway_Homo sapiens_hsa043400.82798291
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82536574
94Tight junction_Homo sapiens_hsa045300.82108787
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80811076
96Osteoclast differentiation_Homo sapiens_hsa043800.80452858
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80094507
98Chemokine signaling pathway_Homo sapiens_hsa040620.79453435
99mRNA surveillance pathway_Homo sapiens_hsa030150.79097233
100Thyroid hormone synthesis_Homo sapiens_hsa049180.78626716
101Hepatitis C_Homo sapiens_hsa051600.78126544
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77937944
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77822107
104Hepatitis B_Homo sapiens_hsa051610.77757390
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77661332
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77148055
107Melanoma_Homo sapiens_hsa052180.76327856
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76319519
109Fructose and mannose metabolism_Homo sapiens_hsa000510.76115341
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.75686281
111Hippo signaling pathway_Homo sapiens_hsa043900.75503856
112Calcium signaling pathway_Homo sapiens_hsa040200.73955815
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73896947
114Synaptic vesicle cycle_Homo sapiens_hsa047210.73821261
115Endocytosis_Homo sapiens_hsa041440.73581245
116Pathways in cancer_Homo sapiens_hsa052000.72321822
117Glucagon signaling pathway_Homo sapiens_hsa049220.72199506
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.70709594
119Thyroid cancer_Homo sapiens_hsa052160.70266488
120HIF-1 signaling pathway_Homo sapiens_hsa040660.68948034
121Toxoplasmosis_Homo sapiens_hsa051450.68792438
122Oocyte meiosis_Homo sapiens_hsa041140.68234395
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64993054
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64501868
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.64321869
126Vibrio cholerae infection_Homo sapiens_hsa051100.62806561
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.61981751
128FoxO signaling pathway_Homo sapiens_hsa040680.60022287
129TNF signaling pathway_Homo sapiens_hsa046680.56001335
130Apoptosis_Homo sapiens_hsa042100.54183063
131Pentose phosphate pathway_Homo sapiens_hsa000300.53884151

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