RAI2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of this retinoic acid-induced gene has not yet been determined but it may play a role in development. The chromosomal location of this gene designates it to be a candidate for diseases such as Nance-Horan syndrome, sensorineural deafness, non-specific X-linked mental retardation, oral-facial-digital syndrome, and Fried syndrome. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.14454581
2COPI coating of Golgi vesicle (GO:0048205)5.14454581
3sarcomere organization (GO:0045214)4.58546624
4thyroid hormone generation (GO:0006590)4.10418264
5tricarboxylic acid cycle (GO:0006099)4.06255138
6nucleobase catabolic process (GO:0046113)4.05326934
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.72556465
8cardiac myofibril assembly (GO:0055003)3.71699723
9detection of calcium ion (GO:0005513)3.70341488
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.66149365
11NADH metabolic process (GO:0006734)3.62961885
12regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.61684178
13glycine transport (GO:0015816)3.61395867
14peptide hormone processing (GO:0016486)3.57832735
15pyrimidine nucleobase catabolic process (GO:0006208)3.55631731
16regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.48008858
17retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.47248644
18negative regulation of potassium ion transmembrane transport (GO:1901380)3.39345724
19plasma membrane repair (GO:0001778)3.38996218
20thyroid hormone metabolic process (GO:0042403)3.38668759
21regulation of membrane repolarization (GO:0060306)3.36489148
22myofibril assembly (GO:0030239)3.34878050
23positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.31999539
24response to parathyroid hormone (GO:0071107)3.22069762
25positive regulation of insulin secretion (GO:0032024)3.21646080
26carnitine shuttle (GO:0006853)3.20688101
27positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.15396518
28growth hormone secretion (GO:0030252)3.15109620
29sarcoplasmic reticulum calcium ion transport (GO:0070296)3.14157846
30cardiac muscle contraction (GO:0060048)3.13704512
31regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.13605323
32cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.08632779
33positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.08562030
34negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.06285972
35ventricular cardiac muscle cell action potential (GO:0086005)3.05656067
36maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.99902756
37regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.99168007
38membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.99000139
39regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.97039966
40positive regulation of vesicle fusion (GO:0031340)2.95957391
41mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.94720566
42negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93104342
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.91947586
44synaptic vesicle maturation (GO:0016188)2.91459537
45gamma-aminobutyric acid transport (GO:0015812)2.91343541
46peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.91289038
47nitric oxide mediated signal transduction (GO:0007263)2.89736895
48muscle filament sliding (GO:0030049)2.87980780
49actin-myosin filament sliding (GO:0033275)2.87980780
50heart trabecula formation (GO:0060347)2.86822818
51endocrine pancreas development (GO:0031018)2.86264573
52oxaloacetate metabolic process (GO:0006107)2.86127427
53regulation of cell communication by electrical coupling (GO:0010649)2.84507665
54positive regulation of glycolytic process (GO:0045821)2.83477725
55negative regulation of cAMP-mediated signaling (GO:0043951)2.83233440
56cell communication by electrical coupling (GO:0010644)2.82449724
57regulation of acyl-CoA biosynthetic process (GO:0050812)2.81628461
58neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.81613408
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.81001585
60membrane repolarization during action potential (GO:0086011)2.80583383
61cell communication involved in cardiac conduction (GO:0086065)2.80494566
62positive regulation of amino acid transport (GO:0051957)2.79256375
63protein retention in ER lumen (GO:0006621)2.78432243
64actomyosin structure organization (GO:0031032)2.78074539
65regulation of insulin secretion (GO:0050796)2.77924058
66glutamate secretion (GO:0014047)2.77910844
67toxin metabolic process (GO:0009404)2.76347287
68positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.74162338
69response to dietary excess (GO:0002021)2.74107813
70succinate metabolic process (GO:0006105)2.73140878
71activation of protein kinase A activity (GO:0034199)2.72349862
72regulation of heart rate by cardiac conduction (GO:0086091)2.70873912
73cardiac conduction (GO:0061337)2.70026040
74fatty acid transmembrane transport (GO:1902001)2.69729099
75regulation of actin filament-based movement (GO:1903115)2.66913929
76cellular response to glucagon stimulus (GO:0071377)2.66625472
77energy coupled proton transport, down electrochemical gradient (GO:0015985)2.66173738
78ATP synthesis coupled proton transport (GO:0015986)2.66173738
79insulin secretion (GO:0030073)2.64188874
80neurotransmitter secretion (GO:0007269)2.63821991
81COPII vesicle coating (GO:0048208)2.62739419
82regulation of skeletal muscle contraction (GO:0014819)2.61916501
83respiratory electron transport chain (GO:0022904)2.60647700
84positive regulation of peptide hormone secretion (GO:0090277)2.60090574
85negative regulation of cytosolic calcium ion concentration (GO:0051481)2.57743678
86electron transport chain (GO:0022900)2.56928303
87regulation of hexokinase activity (GO:1903299)2.56461248
88regulation of glucokinase activity (GO:0033131)2.56461248
89striated muscle contraction (GO:0006941)2.56432769
90regulation of sarcomere organization (GO:0060297)2.55096887
91regulation of cofactor metabolic process (GO:0051193)2.54452535
92regulation of coenzyme metabolic process (GO:0051196)2.54452535
93dendritic spine morphogenesis (GO:0060997)2.53333487
94positive regulation of peptide secretion (GO:0002793)2.53202391
95regulation of type B pancreatic cell apoptotic process (GO:2000674)2.52706711
96tricarboxylic acid metabolic process (GO:0072350)2.52262615
97auditory receptor cell differentiation (GO:0042491)2.51259697
98regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.51169782
99macroautophagy (GO:0016236)2.50605955
100regulation of peptide hormone secretion (GO:0090276)2.50182994
101negative regulation of JUN kinase activity (GO:0043508)2.49632100
102regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.49545021
103positive regulation of glycogen biosynthetic process (GO:0045725)2.49449698
104regulation of heart rate (GO:0002027)2.48695409
105regulation of synapse structural plasticity (GO:0051823)2.48362675
106regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.48260688
107regulation of relaxation of muscle (GO:1901077)2.47868969
108regulation of synaptic vesicle exocytosis (GO:2000300)2.47779982
109positive regulation of cation channel activity (GO:2001259)2.47709951
110peptide hormone secretion (GO:0030072)2.47343413
111vocalization behavior (GO:0071625)2.46986369
112relaxation of cardiac muscle (GO:0055119)2.46205176
113regulation of peptide secretion (GO:0002791)2.45633962
114regulation of autophagic vacuole assembly (GO:2000785)2.44694835
115negative regulation of potassium ion transport (GO:0043267)2.44262247
116positive regulation of heart rate (GO:0010460)2.42566318
117neurotransmitter biosynthetic process (GO:0042136)2.42500540
118actin-mediated cell contraction (GO:0070252)2.41439052
119glandular epithelial cell differentiation (GO:0002067)2.41224978
120cardiac muscle hypertrophy (GO:0003300)2.41115984
121peptide secretion (GO:0002790)2.40243783
122regulation of synaptic vesicle transport (GO:1902803)2.40167543
123positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.39911159
124cardiac muscle cell action potential involved in contraction (GO:0086002)2.39887738
125positive regulation of amine transport (GO:0051954)2.38774376
126cellular ketone body metabolic process (GO:0046950)2.37525934
127epithelial cell fate commitment (GO:0072148)2.36821063
128neuron cell-cell adhesion (GO:0007158)2.36575850
129glycerophospholipid catabolic process (GO:0046475)2.36528524
130inositol phosphate catabolic process (GO:0071545)2.34034167
131regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.33020662
132long term synaptic depression (GO:0060292)2.30910096
133regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.30137819
134peroxisome fission (GO:0016559)2.29121101
135regulation of calcium ion-dependent exocytosis (GO:0017158)2.24044704
136regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.23886020
137signal release (GO:0023061)2.21880946
138glycosphingolipid biosynthetic process (GO:0006688)2.21142810
139regulation of energy homeostasis (GO:2000505)2.19526492
140L-serine transport (GO:0015825)2.18973298
141positive regulation of glycogen metabolic process (GO:0070875)2.18137224
142ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.16903571
143regulation of vesicle fusion (GO:0031338)2.16498288
144synapse assembly (GO:0007416)2.14670579
145synaptic vesicle exocytosis (GO:0016079)2.12847547
146synaptic vesicle docking involved in exocytosis (GO:0016081)2.12005325
147potassium ion export (GO:0071435)2.11891223
148positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.11171590
149positive regulation of sodium ion transport (GO:0010765)2.10125794
150regulation of vacuole organization (GO:0044088)2.08901740
151ethanol oxidation (GO:0006069)2.07551167
152startle response (GO:0001964)2.06522259
153presynaptic membrane assembly (GO:0097105)2.06457180
154calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.06215969
155regulation of short-term neuronal synaptic plasticity (GO:0048172)2.05304109
156coenzyme catabolic process (GO:0009109)2.04986835
157cGMP metabolic process (GO:0046068)2.04545615
158prostate gland growth (GO:0060736)2.04338600
159transcytosis (GO:0045056)2.03161993
160regulation of transcription involved in cell fate commitment (GO:0060850)2.02783893
161ketone body metabolic process (GO:1902224)2.02288168
162response to monoamine (GO:0071867)2.01320907
163response to catecholamine (GO:0071869)2.01320907
164calcium ion-dependent exocytosis (GO:0017156)2.00216472
165G-protein coupled glutamate receptor signaling pathway (GO:0007216)1.99542821
166negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)1.98368402
167membrane hyperpolarization (GO:0060081)1.97317151
168phosphorylated carbohydrate dephosphorylation (GO:0046838)1.97180468
169inositol phosphate dephosphorylation (GO:0046855)1.97180468
170presynaptic membrane organization (GO:0097090)1.97016087

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.85969217
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.86116075
3IGF1R_20145208_ChIP-Seq_DFB_Human2.38308116
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.37159886
5GBX2_23144817_ChIP-Seq_PC3_Human2.34526978
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.29220814
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.26120611
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22717090
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17780190
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.17623247
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.16053314
12ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.98920814
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.98222330
14EZH2_27304074_Chip-Seq_ESCs_Mouse1.94720531
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93529712
16* REST_18959480_ChIP-ChIP_MESCs_Mouse1.88191376
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.85844846
18EZH2_27294783_Chip-Seq_ESCs_Mouse1.84886121
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84757794
20REST_21632747_ChIP-Seq_MESCs_Mouse1.79665141
21NR3C1_23031785_ChIP-Seq_PC12_Mouse1.71746145
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67485462
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67485462
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66358406
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.66305682
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65633003
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65503093
28DROSHA_22980978_ChIP-Seq_HELA_Human1.65353379
29* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63854517
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61203394
31DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.49527715
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43375228
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.42786361
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.42725131
35* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.36133836
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36103060
37SOX2_21211035_ChIP-Seq_LN229_Gbm1.35668059
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.34563117
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32760766
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.30425611
41AR_25329375_ChIP-Seq_VCAP_Human1.30159043
42TBX20_22328084_ChIP-Seq_HEART_Mouse1.29537988
43TBX20_22080862_ChIP-Seq_HEART_Mouse1.29537988
44VDR_22108803_ChIP-Seq_LS180_Human1.28728137
45* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27726509
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25956796
47* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24861639
48SMAD4_21799915_ChIP-Seq_A2780_Human1.24581305
49ZNF274_21170338_ChIP-Seq_K562_Hela1.19696642
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17644710
51AHR_22903824_ChIP-Seq_MCF-7_Human1.16111423
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16024081
53ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15141265
54* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14587606
55MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.13663427
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12552008
57* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12517197
58RNF2_27304074_Chip-Seq_NSC_Mouse1.11728515
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11476402
60FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11222017
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11043476
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10410217
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.10065566
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08472764
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08008984
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07082827
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06809376
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.06501879
69ER_23166858_ChIP-Seq_MCF-7_Human1.04330578
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.04201467
71GATA1_22025678_ChIP-Seq_K562_Human1.04040732
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03313883
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03161231
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02762961
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02592132
76AR_19668381_ChIP-Seq_PC3_Human1.00716803
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00397675
78CLOCK_20551151_ChIP-Seq_293T_Human0.99456604
79BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98769606
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98645243
81PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98596218
82CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98561573
83SMAD4_21741376_ChIP-Seq_HESCs_Human0.98352556
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98127360
85* RUNX2_22187159_ChIP-Seq_PCA_Human0.97285722
86* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96953203
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95706198
88STAT3_23295773_ChIP-Seq_U87_Human0.95464119
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94059086
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93900528
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93407751
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93274050
93CBP_20019798_ChIP-Seq_JUKART_Human0.92686181
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92686181
95POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91212012
96ESR2_21235772_ChIP-Seq_MCF-7_Human0.90538615
97P300_19829295_ChIP-Seq_ESCs_Human0.90330706
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89940035
99YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89801747
100BCAT_22108803_ChIP-Seq_LS180_Human0.89453277
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89421614
102ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88648792
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88324534
104CTCF_27219007_Chip-Seq_Bcells_Human0.87900293
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87342184
106IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86806226
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86671237
108* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86293309
109RING1B_27294783_Chip-Seq_NPCs_Mouse0.85732376
110REST_19997604_ChIP-ChIP_NEURONS_Mouse0.85107555
111CBX2_27304074_Chip-Seq_ESCs_Mouse0.84976662
112SMAD3_21741376_ChIP-Seq_HESCs_Human0.84819720
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84760546
114TAF15_26573619_Chip-Seq_HEK293_Human0.84468242
115RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83936530
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83605574
117TCF4_23295773_ChIP-Seq_U87_Human0.83249487
118RING1B_27294783_Chip-Seq_ESCs_Mouse0.82605791
119NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82461848
120FUS_26573619_Chip-Seq_HEK293_Human0.81916206
121TP53_20018659_ChIP-ChIP_R1E_Mouse0.81527678
122SMAD3_21741376_ChIP-Seq_EPCs_Human0.81249017
123TCF4_22108803_ChIP-Seq_LS180_Human0.80786129
124TRIM28_21343339_ChIP-Seq_HEK293_Human0.80625939
125FOXH1_21741376_ChIP-Seq_ESCs_Human0.79861369
126RARG_19884340_ChIP-ChIP_MEFs_Mouse0.79499141
127FOXA1_25552417_ChIP-Seq_VCAP_Human0.78526147
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.77890357
129AR_21572438_ChIP-Seq_LNCaP_Human0.77538052
130KDM2B_26808549_Chip-Seq_REH_Human0.76920690
131FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76235671

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.37570311
2MP0000013_abnormal_adipose_tissue4.39653953
3MP0003646_muscle_fatigue3.25361521
4MP0003183_abnormal_peptide_metabolism3.06119125
5MP0000751_myopathy3.05527661
6MP0002909_abnormal_adrenal_gland2.92723621
7MP0004215_abnormal_myocardial_fiber2.73340731
8MP0004036_abnormal_muscle_relaxation2.62539543
9MP0004084_abnormal_cardiac_muscle2.62477431
10MP0005645_abnormal_hypothalamus_physiol2.50302023
11MP0000749_muscle_degeneration2.38573026
12MP0009780_abnormal_chondrocyte_physiolo2.31083093
13MP0000003_abnormal_adipose_tissue2.29690377
14MP0004043_abnormal_pH_regulation2.22227676
15MP0003122_maternal_imprinting2.11198899
16MP0004233_abnormal_muscle_weight1.99733243
17MP0004270_analgesia1.99446514
18MP0010386_abnormal_urinary_bladder1.96105461
19MP0003011_delayed_dark_adaptation1.94446272
20MP0003195_calcinosis1.92102030
21MP0002638_abnormal_pupillary_reflex1.87542904
22MP0004130_abnormal_muscle_cell1.85053731
23MP0000678_abnormal_parathyroid_gland1.84890534
24MP0002269_muscular_atrophy1.83662288
25MP0004145_abnormal_muscle_electrophysio1.80879286
26MP0001984_abnormal_olfaction1.80685675
27MP0005330_cardiomyopathy1.72738878
28MP0001944_abnormal_pancreas_morphology1.70012115
29MP0005379_endocrine/exocrine_gland_phen1.69987040
30MP0003787_abnormal_imprinting1.65654614
31MP0002972_abnormal_cardiac_muscle1.63740521
32MP0004085_abnormal_heartbeat1.61122126
33MP0005670_abnormal_white_adipose1.60989235
34MP0002234_abnormal_pharynx_morphology1.58796852
35MP0005620_abnormal_muscle_contractility1.55788758
36MP0002078_abnormal_glucose_homeostasis1.51860969
37MP0002106_abnormal_muscle_physiology1.50749523
38MP0000462_abnormal_digestive_system1.49253791
39MP0004087_abnormal_muscle_fiber1.47650573
40MP0005375_adipose_tissue_phenotype1.47331059
41MP0001986_abnormal_taste_sensitivity1.47022381
42MP0003137_abnormal_impulse_conducting1.46409925
43MP0005503_abnormal_tendon_morphology1.44600597
44MP0002102_abnormal_ear_morphology1.44257274
45MP0002693_abnormal_pancreas_physiology1.42560485
46MP0000747_muscle_weakness1.42125001
47MP0001501_abnormal_sleep_pattern1.40656267
48MP0001664_abnormal_digestion1.40019620
49MP0001270_distended_abdomen1.38971479
50MP0000750_abnormal_muscle_regeneration1.32234588
51MP0005369_muscle_phenotype1.31700768
52MP0000759_abnormal_skeletal_muscle1.26284187
53MP0002295_abnormal_pulmonary_circulatio1.24872244
54MP0003283_abnormal_digestive_organ1.23614603
55MP0006036_abnormal_mitochondrial_physio1.22590650
56MP0003635_abnormal_synaptic_transmissio1.21821761
57MP0006138_congestive_heart_failure1.20706152
58MP0010234_abnormal_vibrissa_follicle1.20063515
59MP0005084_abnormal_gallbladder_morpholo1.19404069
60MP0004859_abnormal_synaptic_plasticity1.17533820
61MP0001544_abnormal_cardiovascular_syste1.16735164
62MP0005385_cardiovascular_system_phenoty1.16735164
63MP0002254_reproductive_system_inflammat1.16263011
64MP0010329_abnormal_lipoprotein_level1.16041676
65MP0006072_abnormal_retinal_apoptosis1.14351736
66MP0000681_abnormal_thyroid_gland1.10406896
67MP0005551_abnormal_eye_electrophysiolog1.10114837
68MP0001905_abnormal_dopamine_level1.09168361
69MP0008961_abnormal_basal_metabolism1.07900282
70MP0002734_abnormal_mechanical_nocicepti1.05788634
71MP0000230_abnormal_systemic_arterial1.05352108
72MP0002877_abnormal_melanocyte_morpholog1.04483621
73MP0005275_abnormal_skin_tensile1.04361676
74MP0004484_altered_response_of1.03153583
75MP0002184_abnormal_innervation1.02819642
76MP0004019_abnormal_vitamin_homeostasis1.02696659
77MP0006276_abnormal_autonomic_nervous1.02660692
78MP0003959_abnormal_lean_body1.02050948
79MP0008775_abnormal_heart_ventricle1.01817307
80MP0005220_abnormal_exocrine_pancreas1.01758530
81MP0002277_abnormal_respiratory_mucosa1.00931357
82MP0001756_abnormal_urination1.00438063
83MP0001502_abnormal_circadian_rhythm1.00237639
84MP0002876_abnormal_thyroid_physiology0.99979949
85MP0003953_abnormal_hormone_level0.99798315
86MP0000538_abnormal_urinary_bladder0.99770702
87MP0001765_abnormal_ion_homeostasis0.98681775
88MP0001486_abnormal_startle_reflex0.98349608
89MP0002272_abnormal_nervous_system0.98176279
90MP0002063_abnormal_learning/memory/cond0.98147875
91MP0010368_abnormal_lymphatic_system0.98085819
92MP0005535_abnormal_body_temperature0.97099257
93MP0005187_abnormal_penis_morphology0.96384302
94MP0002572_abnormal_emotion/affect_behav0.96007790
95MP0008995_early_reproductive_senescence0.94377191
96MP0002163_abnormal_gland_morphology0.94148672
97MP0005253_abnormal_eye_physiology0.94101545
98MP0002139_abnormal_hepatobiliary_system0.93603233
99MP0001968_abnormal_touch/_nociception0.92767824
100MP0009745_abnormal_behavioral_response0.92643686
101MP0005332_abnormal_amino_acid0.92599661
102MP0005666_abnormal_adipose_tissue0.91588930
103MP0003879_abnormal_hair_cell0.90440178
104MP0002733_abnormal_thermal_nociception0.90262983
105MP0005167_abnormal_blood-brain_barrier0.89246115
106MP0010630_abnormal_cardiac_muscle0.89026646
107MP0005365_abnormal_bile_salt0.88495351
108MP0005646_abnormal_pituitary_gland0.88096702
109MP0002127_abnormal_cardiovascular_syste0.84838015
110MP0006292_abnormal_olfactory_placode0.84496585
111MP0002064_seizures0.84267844
112MP0004510_myositis0.83503970
113MP0002735_abnormal_chemical_nociception0.82296040
114MP0002249_abnormal_larynx_morphology0.82254161
115MP0002822_catalepsy0.80155228
116MP0002557_abnormal_social/conspecific_i0.79406878
117MP0003633_abnormal_nervous_system0.78954498
118MP0004858_abnormal_nervous_system0.78782690
119MP0000631_abnormal_neuroendocrine_gland0.77818110
120MP0001529_abnormal_vocalization0.76704236
121MP0008569_lethality_at_weaning0.75281661
122MP0002896_abnormal_bone_mineralization0.74937777
123MP0005448_abnormal_energy_balance0.74686833
124MP0004924_abnormal_behavior0.74666743
125MP0005386_behavior/neurological_phenoty0.74666743
126MP0002751_abnormal_autonomic_nervous0.74324676
127MP0001970_abnormal_pain_threshold0.72737212
128MP0002108_abnormal_muscle_morphology0.72235778
129MP0001188_hyperpigmentation0.72187656
130MP0002069_abnormal_eating/drinking_beha0.69916651
131MP0003880_abnormal_central_pattern0.68484002
132MP0002971_abnormal_brown_adipose0.67366193
133MP0001440_abnormal_grooming_behavior0.67061792
134MP0009046_muscle_twitch0.66647230

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)4.94279289
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.70125076
3Ketoacidosis (HP:0001993)4.65019993
4Hypoglycemic coma (HP:0001325)4.43328072
5Sudden death (HP:0001699)4.25741036
6Hyperglycemia (HP:0003074)4.22527313
7Pheochromocytoma (HP:0002666)4.09047717
8Hypoglycemic seizures (HP:0002173)4.02440482
9Calf muscle hypertrophy (HP:0008981)3.83092297
10Neuroendocrine neoplasm (HP:0100634)3.72554035
11Exercise-induced myalgia (HP:0003738)3.71342650
12Myoglobinuria (HP:0002913)3.65186982
13Muscle hypertrophy of the lower extremities (HP:0008968)3.59211402
14Symptomatic seizures (HP:0011145)3.46788582
15Late onset (HP:0003584)3.45951602
16Large for gestational age (HP:0001520)3.34129777
17Muscle fiber splitting (HP:0003555)3.30812994
18Pancreatic islet-cell hyperplasia (HP:0004510)3.29472811
19Retinal atrophy (HP:0001105)3.23861249
20Palpitations (HP:0001962)3.23722795
21Abnormality of endocrine pancreas physiology (HP:0012093)3.21311708
22Abnormality of the pancreatic islet cells (HP:0006476)3.21311708
23Abnormality of calcium-phosphate metabolism (HP:0100530)3.21026209
24Ventricular tachycardia (HP:0004756)3.20144077
25Prolonged QT interval (HP:0001657)3.19708353
26Insulin-resistant diabetes mellitus (HP:0000831)3.17180811
27Atrial fibrillation (HP:0005110)3.14980429
28Ketosis (HP:0001946)3.04644484
29Abnormality of the calf musculature (HP:0001430)3.00189082
30Primary atrial arrhythmia (HP:0001692)2.98390579
31Syncope (HP:0001279)2.97770508
32Bundle branch block (HP:0011710)2.96195171
33Exercise-induced muscle cramps (HP:0003710)2.93436315
34Agitation (HP:0000713)2.88174891
35Supraventricular tachycardia (HP:0004755)2.81483473
36Enlarged penis (HP:0000040)2.76518072
37Congenital sensorineural hearing impairment (HP:0008527)2.76508515
38Supraventricular arrhythmia (HP:0005115)2.74843399
39Acute necrotizing encephalopathy (HP:0006965)2.59054322
40Asymmetric septal hypertrophy (HP:0001670)2.57693790
41EMG: myopathic abnormalities (HP:0003458)2.56214444
42Abnormal mitochondria in muscle tissue (HP:0008316)2.54158538
43Abnormality of the left ventricular outflow tract (HP:0011103)2.53876266
44Subaortic stenosis (HP:0001682)2.53876266
45Hyporeflexia of lower limbs (HP:0002600)2.51253980
46Ventricular fibrillation (HP:0001663)2.49200846
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.45158899
48Lipoatrophy (HP:0100578)2.43942912
49Right ventricular cardiomyopathy (HP:0011663)2.42809562
50Ulnar claw (HP:0001178)2.42699832
51Abnormal EKG (HP:0003115)2.33063530
52Goiter (HP:0000853)2.28201256
53Myotonia (HP:0002486)2.26989810
54Absent speech (HP:0001344)2.26769399
55Dilated cardiomyopathy (HP:0001644)2.26225489
56Abnormality of vitamin B metabolism (HP:0004340)2.26209380
57Polyphagia (HP:0002591)2.25805978
58Neoplasm of the adrenal gland (HP:0100631)2.25794753
59Left ventricular hypertrophy (HP:0001712)2.23121073
60Acute encephalopathy (HP:0006846)2.21938902
61Ventricular arrhythmia (HP:0004308)2.21666558
62Generalized aminoaciduria (HP:0002909)2.17720911
63Abnormality of aromatic amino acid family metabolism (HP:0004338)2.16496941
64Abnormality of fatty-acid metabolism (HP:0004359)2.15083226
65Intention tremor (HP:0002080)2.15053533
66Methylmalonic acidemia (HP:0002912)2.14914307
67Hyperkalemia (HP:0002153)2.14610826
68Hypercortisolism (HP:0001578)2.14165748
69Abnormality of vitamin metabolism (HP:0100508)2.13852652
70Heart block (HP:0012722)2.13240411
71Myokymia (HP:0002411)2.10917884
72Anxiety (HP:0000739)2.10728477
73Progressive macrocephaly (HP:0004481)2.10360347
74Limb dystonia (HP:0002451)2.09858733
75Growth hormone excess (HP:0000845)2.09397017
76Abnormal drinking behavior (HP:0030082)2.09339713
77Polydipsia (HP:0001959)2.09339713
78Lymphangioma (HP:0100764)2.05222712
79Decreased circulating renin level (HP:0003351)2.04464311
80EEG with generalized epileptiform discharges (HP:0011198)2.03502608
81Epileptiform EEG discharges (HP:0011182)2.03497984
82Sleep apnea (HP:0010535)2.02451513
83Gout (HP:0001997)2.02317849
84Hypsarrhythmia (HP:0002521)2.00623757
85Oligomenorrhea (HP:0000876)1.99490184
86Rhabdomyolysis (HP:0003201)1.99293225
87Hypomagnesemia (HP:0002917)1.97659804
88Abnormal atrioventricular conduction (HP:0005150)1.96431893
89Long toe (HP:0010511)1.95850443
90Gait imbalance (HP:0002141)1.95637134
91Difficulty running (HP:0009046)1.95212337
92Medial flaring of the eyebrow (HP:0010747)1.94483931
93Menstrual irregularities (HP:0000858)1.93800682
94Hepatic necrosis (HP:0002605)1.93415486
95Neoplasm of the heart (HP:0100544)1.92568577
96Fetal akinesia sequence (HP:0001989)1.90835204
97Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89499794
98Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89499794
99Exocrine pancreatic insufficiency (HP:0001738)1.89025770
100Hyperphosphatemia (HP:0002905)1.88393964
101Frequent falls (HP:0002359)1.87797298
102Buphthalmos (HP:0000557)1.86865498
103Increased connective tissue (HP:0009025)1.86569260
104Testicular neoplasm (HP:0010788)1.86224443
105Abnormal eating behavior (HP:0100738)1.85707027
106Hyperthyroidism (HP:0000836)1.85230583
107Delayed CNS myelination (HP:0002188)1.84885423
108Depression (HP:0000716)1.83921780
109Hemiparesis (HP:0001269)1.83355403
110Hepatoblastoma (HP:0002884)1.83284428
111Insulin resistance (HP:0000855)1.83261372
112Rimmed vacuoles (HP:0003805)1.82963267
113Absent eyebrow (HP:0002223)1.82883170
114Abnormality of proline metabolism (HP:0010907)1.82879130
115Hydroxyprolinuria (HP:0003080)1.82879130
116Difficulty climbing stairs (HP:0003551)1.81172096
117Atrioventricular block (HP:0001678)1.79918926
118Neoplasm of the peripheral nervous system (HP:0100007)1.79450131
119Patent foramen ovale (HP:0001655)1.79357213
120Hypokalemia (HP:0002900)1.78137788
121Broad-based gait (HP:0002136)1.77668000
122Mitochondrial inheritance (HP:0001427)1.77201939
123Muscle stiffness (HP:0003552)1.77070135
124Torticollis (HP:0000473)1.75786512
125Prominent supraorbital ridges (HP:0000336)1.75482611
126Bradycardia (HP:0001662)1.74904394
127Abnormality of potassium homeostasis (HP:0011042)1.74089925
128Abnormality of the renal cortex (HP:0011035)1.73065169
129Hypothermia (HP:0002045)1.72677016
130Congenital primary aphakia (HP:0007707)1.72420836
131Epileptic encephalopathy (HP:0200134)1.72174830
132Increased CSF protein (HP:0002922)1.71745437
133Dysdiadochokinesis (HP:0002075)1.71650204
134Failure to thrive in infancy (HP:0001531)1.71597001
135Increased variability in muscle fiber diameter (HP:0003557)1.71567842
136Muscular hypotonia of the trunk (HP:0008936)1.71042260
137Lipid accumulation in hepatocytes (HP:0006561)1.69814806
138Generalized myoclonic seizures (HP:0002123)1.69225099
139Increased muscle lipid content (HP:0009058)1.69200584
140Skin nodule (HP:0200036)1.69000702
141Central scotoma (HP:0000603)1.68773801
142Abnormality of renal excretion (HP:0011036)1.66334611
143Increased CSF lactate (HP:0002490)1.66226054
144Resting tremor (HP:0002322)1.65640793
145Action tremor (HP:0002345)1.65619590
146Rectal prolapse (HP:0002035)1.64485841
147Hyperventilation (HP:0002883)1.64443606
148Limb-girdle muscle atrophy (HP:0003797)1.64383906
149Proximal tubulopathy (HP:0000114)1.64237832
150Abnormality of magnesium homeostasis (HP:0004921)1.64067311
151Spastic tetraplegia (HP:0002510)1.63774401
152Bronchomalacia (HP:0002780)1.63736288
153Intellectual disability, progressive (HP:0006887)1.62167787
154Vascular calcification (HP:0004934)1.61766793
155Glycosuria (HP:0003076)1.61001415
156Abnormality of urine glucose concentration (HP:0011016)1.61001415

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK36.07973318
2MAPK154.18704990
3AKT34.01654359
4FGFR22.76596169
5INSRR2.71893057
6TTN2.52189671
7PHKG22.46898441
8PHKG12.46898441
9WNK42.42912994
10STK38L1.99005624
11MYLK1.93727113
12PIK3CG1.86568631
13PAK31.83037109
14GRK11.79717202
15UHMK11.70897988
16PRKD31.65557225
17BRAF1.65316951
18LMTK21.62378583
19PDK41.59465792
20PDK31.59465792
21OBSCN1.59142666
22NTRK31.56126527
23CSNK1G21.53509310
24MARK11.50364031
25CSNK1G11.47096843
26SGK21.43514641
27FRK1.43060397
28BMPR1B1.42382579
29PINK11.42003765
30SGK4941.40790356
31SGK2231.40790356
32CSNK1G31.39779978
33BCKDK1.37188468
34TESK11.32107593
35KSR21.23695703
36MUSK1.21868184
37FER1.19553256
38DAPK21.16863724
39TAOK31.16223276
40MAP3K21.15287475
41EPHA31.15090169
42DMPK1.12428451
43CDC42BPA1.09839260
44SGK31.07916177
45CASK1.05244602
46CAMK2D1.02557712
47HIPK21.02123454
48CSNK1A1L1.00515625
49NLK0.99808432
50MAP3K10.99514922
51TAOK10.99125762
52MAP3K40.94878942
53SIK10.94778665
54NME10.93393602
55PRKAA20.92032868
56FGFR30.90785133
57DYRK1B0.89359736
58TRIB30.88711088
59STK380.87442346
60RIPK10.87188827
61MAP2K60.87070436
62DAPK10.86902963
63TIE10.86547241
64PRKCH0.86341174
65MAP2K10.86225927
66KSR10.85546880
67MAP3K70.84853418
68WNK10.84230956
69MAPKAPK30.83960417
70DYRK20.83517377
71TRPM70.83381411
72BCR0.83071161
73GRK50.83059755
74PRKG20.82911309
75PIK3CA0.82247771
76MAPK120.79918930
77CAMKK20.79738696
78MAP2K70.78793063
79EPHB10.78558583
80PRKD20.77886707
81NTRK10.75748338
82GRK70.74394100
83LATS10.73989096
84PRKCE0.73710261
85MAP4K20.73102177
86LIMK10.70954952
87PDGFRA0.70286633
88IRAK10.69984385
89ADRBK20.69949935
90TNK20.69469877
91SIK30.69266139
92ARAF0.69164318
93MAP2K40.67215336
94PRKCZ0.66978731
95PTK2B0.65852675
96STK240.64921008
97PRKAA10.64601910
98CAMK2A0.64332988
99PDK20.61979652
100EPHA40.61538892
101ERN10.60815059
102PRKD10.57242283
103PASK0.56311832
104PTK20.52514233
105SGK10.51653039
106MAP3K120.51137636
107MAP3K60.49947919
108PDPK10.49559745
109OXSR10.49231734
110PAK60.49161185
111CAMK1G0.48849871
112CDK50.48718043
113PRPF4B0.48597821
114PRKCG0.47858583
115PRKG10.47716522
116CAMK2B0.47148558
117PNCK0.46563019
118PRKACA0.45484067
119MAP3K90.44890146
120LATS20.44043996
121NTRK20.43875271
122NEK10.43680249
123CDK30.43644259
124CAMK2G0.42544151
125PTK60.42012919
126DYRK30.41683212
127RPS6KA20.41409292
128DAPK30.41353567
129GSK3A0.41255940
130STK110.40793542
131PRKACB0.40602722
132PKN20.40453576
133RET0.40437872
134PRKACG0.40298037
135MINK10.40228704
136CSNK1A10.39786740
137CAMK40.38981431
138TRIM280.38897001
139ROCK10.37545213
140ERBB30.36654464
141FLT30.35092486
142MARK20.34389958
143CAMK10.34077224
144DYRK1A0.33174814
145MAPK130.32714500

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.59268741
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.05884823
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.08250904
4Insulin secretion_Homo sapiens_hsa049112.52697969
5Oxidative phosphorylation_Homo sapiens_hsa001902.33597305
6Cardiac muscle contraction_Homo sapiens_hsa042602.20217326
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09163150
8Parkinsons disease_Homo sapiens_hsa050121.95711123
9Protein export_Homo sapiens_hsa030601.83686928
10Dilated cardiomyopathy_Homo sapiens_hsa054141.79881431
11Alzheimers disease_Homo sapiens_hsa050101.73901274
12beta-Alanine metabolism_Homo sapiens_hsa004101.72811781
13Vibrio cholerae infection_Homo sapiens_hsa051101.71448811
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.70032154
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63162354
16Synaptic vesicle cycle_Homo sapiens_hsa047211.61350537
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.56854878
18Type II diabetes mellitus_Homo sapiens_hsa049301.56010076
19Fatty acid degradation_Homo sapiens_hsa000711.52673620
20Circadian entrainment_Homo sapiens_hsa047131.49713400
21Propanoate metabolism_Homo sapiens_hsa006401.49472205
22Collecting duct acid secretion_Homo sapiens_hsa049661.46877623
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43471788
24GABAergic synapse_Homo sapiens_hsa047271.42153786
25Glucagon signaling pathway_Homo sapiens_hsa049221.41059411
26Pyruvate metabolism_Homo sapiens_hsa006201.36857818
27Amphetamine addiction_Homo sapiens_hsa050311.30394275
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28601059
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27881896
30Fatty acid metabolism_Homo sapiens_hsa012121.26894305
31Butanoate metabolism_Homo sapiens_hsa006501.25472209
32Circadian rhythm_Homo sapiens_hsa047101.22868803
33Huntingtons disease_Homo sapiens_hsa050161.21832528
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21287438
35Histidine metabolism_Homo sapiens_hsa003401.18277894
36Cocaine addiction_Homo sapiens_hsa050301.16594944
37Sulfur metabolism_Homo sapiens_hsa009201.13432017
38Dopaminergic synapse_Homo sapiens_hsa047281.13201606
39Renin secretion_Homo sapiens_hsa049241.11459273
40Phototransduction_Homo sapiens_hsa047441.11340475
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10518556
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10357142
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10228466
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09875752
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07543373
46Long-term potentiation_Homo sapiens_hsa047201.06139863
47Fatty acid biosynthesis_Homo sapiens_hsa000611.05588528
48Gastric acid secretion_Homo sapiens_hsa049711.03428352
49Thyroid hormone synthesis_Homo sapiens_hsa049181.02904522
50Taste transduction_Homo sapiens_hsa047421.01304510
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98867563
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.98198551
53Carbon metabolism_Homo sapiens_hsa012000.97060082
54Morphine addiction_Homo sapiens_hsa050320.96551797
55Cholinergic synapse_Homo sapiens_hsa047250.96395493
56Type I diabetes mellitus_Homo sapiens_hsa049400.96104392
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94085269
58Serotonergic synapse_Homo sapiens_hsa047260.92225314
59Insulin signaling pathway_Homo sapiens_hsa049100.90253888
60Oxytocin signaling pathway_Homo sapiens_hsa049210.89095655
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88760738
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87729046
63Regulation of autophagy_Homo sapiens_hsa041400.86879622
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86871075
65Tight junction_Homo sapiens_hsa045300.86456356
66Ovarian steroidogenesis_Homo sapiens_hsa049130.86097722
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85016220
68Caffeine metabolism_Homo sapiens_hsa002320.84926984
69Folate biosynthesis_Homo sapiens_hsa007900.82098351
70cAMP signaling pathway_Homo sapiens_hsa040240.79626051
71Calcium signaling pathway_Homo sapiens_hsa040200.79151964
72Prion diseases_Homo sapiens_hsa050200.77927778
73Bile secretion_Homo sapiens_hsa049760.77527894
74Nicotine addiction_Homo sapiens_hsa050330.77459091
75ABC transporters_Homo sapiens_hsa020100.77369251
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75348240
77Sphingolipid metabolism_Homo sapiens_hsa006000.75037294
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74095354
79Arginine and proline metabolism_Homo sapiens_hsa003300.73971653
80Insulin resistance_Homo sapiens_hsa049310.73562147
81Tryptophan metabolism_Homo sapiens_hsa003800.72330790
82Glutamatergic synapse_Homo sapiens_hsa047240.72324109
83Long-term depression_Homo sapiens_hsa047300.70476208
84Glycerolipid metabolism_Homo sapiens_hsa005610.69727355
85Olfactory transduction_Homo sapiens_hsa047400.69554195
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69458980
87Mineral absorption_Homo sapiens_hsa049780.69290076
88Fatty acid elongation_Homo sapiens_hsa000620.68799979
89Linoleic acid metabolism_Homo sapiens_hsa005910.68407274
90Ether lipid metabolism_Homo sapiens_hsa005650.67841525
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67795292
92Pancreatic secretion_Homo sapiens_hsa049720.66863834
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.66074210
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65661415
95Fat digestion and absorption_Homo sapiens_hsa049750.63979618
96Estrogen signaling pathway_Homo sapiens_hsa049150.63383805
97Chemical carcinogenesis_Homo sapiens_hsa052040.63059118
98Retinol metabolism_Homo sapiens_hsa008300.62328592
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62293697
100Vitamin B6 metabolism_Homo sapiens_hsa007500.61568799
101Tyrosine metabolism_Homo sapiens_hsa003500.59269961
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57534463
103Phenylalanine metabolism_Homo sapiens_hsa003600.55881020
104Starch and sucrose metabolism_Homo sapiens_hsa005000.55614655
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54686580
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53240896
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53214167
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.52482809
109Salivary secretion_Homo sapiens_hsa049700.51478304
110PPAR signaling pathway_Homo sapiens_hsa033200.49973620
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48905224
112Protein digestion and absorption_Homo sapiens_hsa049740.47923311
113N-Glycan biosynthesis_Homo sapiens_hsa005100.47418343
114Melanogenesis_Homo sapiens_hsa049160.47100816
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46744937
116AMPK signaling pathway_Homo sapiens_hsa041520.46025983
117GnRH signaling pathway_Homo sapiens_hsa049120.45501968
118Gap junction_Homo sapiens_hsa045400.45447606
119Lysosome_Homo sapiens_hsa041420.44638393
120Lysine degradation_Homo sapiens_hsa003100.44230881
121Arachidonic acid metabolism_Homo sapiens_hsa005900.43995795
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42948527
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41915217
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41676296
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40739220
126Peroxisome_Homo sapiens_hsa041460.38061157
127Galactose metabolism_Homo sapiens_hsa000520.36568210
128Arginine biosynthesis_Homo sapiens_hsa002200.36181172
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34895960
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34171914
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.33297577
132Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31727679
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29631019

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