RALB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of interferon-beta biosynthetic process (GO:0045357)5.05739486
2positive regulation of interferon-alpha production (GO:0032727)4.55574688
3positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.44109309
4detection of other organism (GO:0098543)4.43292207
5regulation of interferon-alpha production (GO:0032647)4.24649514
6detection of external biotic stimulus (GO:0098581)4.09707436
7neutrophil activation involved in immune response (GO:0002283)4.02350908
8positive regulation of gamma-delta T cell activation (GO:0046645)4.02032775
9detection of bacterium (GO:0016045)4.00586110
10positive regulation by symbiont of host defense response (GO:0052509)3.98533827
11modulation by symbiont of host defense response (GO:0052031)3.98533827
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.98533827
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.98533827
14positive regulation by organism of defense response of other organism involved in symbiotic interact3.98533827
15modulation by symbiont of host immune response (GO:0052553)3.98533827
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.96741835
17negative regulation of cell killing (GO:0031342)3.96741835
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.84456356
19cellular response to virus (GO:0098586)3.83476259
20antigen processing and presentation of endogenous antigen (GO:0019883)3.82214440
21wound healing, spreading of epidermal cells (GO:0035313)3.79886803
22response to peptidoglycan (GO:0032494)3.78028924
23negative regulation of interleukin-12 production (GO:0032695)3.77386909
24leukocyte migration involved in inflammatory response (GO:0002523)3.69670188
25cellular extravasation (GO:0045123)3.69649059
26endothelium development (GO:0003158)3.66168437
27protein localization to endosome (GO:0036010)3.57425939
28detection of biotic stimulus (GO:0009595)3.44794381
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.43738803
30regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.41705479
31cell adhesion mediated by integrin (GO:0033627)3.36098278
32lipopolysaccharide-mediated signaling pathway (GO:0031663)3.33275849
33positive regulation of chemokine biosynthetic process (GO:0045080)3.28262180
34apoptotic cell clearance (GO:0043277)3.26292292
35regulation of mast cell degranulation (GO:0043304)3.21468453
36cellular response to type I interferon (GO:0071357)3.17090769
37type I interferon signaling pathway (GO:0060337)3.17090769
38regulation of integrin activation (GO:0033623)3.16743377
39positive regulation of interferon-beta production (GO:0032728)3.13676211
40positive regulation of Cdc42 GTPase activity (GO:0043089)3.13087021
41production of molecular mediator involved in inflammatory response (GO:0002532)3.10889277
42leukocyte aggregation (GO:0070486)3.10440342
43regulation of T-helper 2 cell differentiation (GO:0045628)3.03747703
44myeloid cell activation involved in immune response (GO:0002275)3.03364445
45regulation of mast cell activation involved in immune response (GO:0033006)2.97760170
46Arp2/3 complex-mediated actin nucleation (GO:0034314)2.97724057
47basement membrane organization (GO:0071711)2.96434671
48regulation of leukocyte degranulation (GO:0043300)2.95785574
49regulation of myeloid leukocyte mediated immunity (GO:0002886)2.94469960
50macrophage activation involved in immune response (GO:0002281)2.93362361
51regulation of B cell receptor signaling pathway (GO:0050855)2.93089455
52germinal center formation (GO:0002467)2.88556061
53wound healing, spreading of cells (GO:0044319)2.86075145
54response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.85820762
55response to host immune response (GO:0052572)2.85820762
56positive regulation of cellular amide metabolic process (GO:0034250)2.85221100
57positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.84732948
58positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.84105529
59positive regulation of type 2 immune response (GO:0002830)2.82272656
60regulation of integrin-mediated signaling pathway (GO:2001044)2.81755787
61neutrophil mediated immunity (GO:0002446)2.78584460
62endodermal cell differentiation (GO:0035987)2.78566695
63positive regulation of receptor recycling (GO:0001921)2.77919184
64establishment of endothelial barrier (GO:0061028)2.76446051
65positive regulation of mast cell activation (GO:0033005)2.74761558
66negative regulation of mast cell activation (GO:0033004)2.74005299
67immunoglobulin mediated immune response (GO:0016064)2.72206157
68detection of molecule of bacterial origin (GO:0032490)2.71697558
69hydrogen peroxide biosynthetic process (GO:0050665)2.71083980
70neutrophil activation (GO:0042119)2.70673231
71T-helper 1 type immune response (GO:0042088)2.69606744
72response to muramyl dipeptide (GO:0032495)2.69358070
73regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.69169043
74vascular endothelial growth factor signaling pathway (GO:0038084)2.68625870
75regulation of type 2 immune response (GO:0002828)2.68065644
76response to host (GO:0075136)2.68031552
77response to host defenses (GO:0052200)2.68031552
78response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.68031552
79negative regulation of erythrocyte differentiation (GO:0045647)2.67828800
80regulation of gamma-delta T cell activation (GO:0046643)2.66829374
81granulocyte activation (GO:0036230)2.65525795
82chondrocyte proliferation (GO:0035988)2.65470446
83regulation of mast cell activation (GO:0033003)2.64487482
84negative regulation of lymphocyte mediated immunity (GO:0002707)2.64083448
85positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.62476011
86retina vasculature morphogenesis in camera-type eye (GO:0061299)2.61282071
87regulation of chemokine biosynthetic process (GO:0045073)2.57172143
88leukocyte apoptotic process (GO:0071887)2.56403010
89myeloid leukocyte activation (GO:0002274)2.56291459
90positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.55897021
91antigen processing and presentation via MHC class Ib (GO:0002475)2.54856855
92superoxide anion generation (GO:0042554)2.53885425
93substrate-dependent cell migration (GO:0006929)2.53192192
94negative regulation of interleukin-17 production (GO:0032700)2.53107338
95regulation of SMAD protein import into nucleus (GO:0060390)2.52246392
96negative regulation of leukocyte mediated immunity (GO:0002704)2.52094007
97regulation of podosome assembly (GO:0071801)2.51540596
98regulation of tolerance induction (GO:0002643)2.51224701
99respiratory burst (GO:0045730)2.51118728
100regulation of dendritic cell antigen processing and presentation (GO:0002604)2.50872318
101regulation of regulated secretory pathway (GO:1903305)2.50365869
102low-density lipoprotein particle clearance (GO:0034383)2.50272372
103phagocytosis, recognition (GO:0006910)2.49808367
104antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.49122426
105positive regulation of leukocyte degranulation (GO:0043302)2.49040593
106sequestering of metal ion (GO:0051238)2.49029005
107cellular response to interferon-alpha (GO:0035457)2.48992323
108leukocyte degranulation (GO:0043299)2.47440505
109neutrophil chemotaxis (GO:0030593)2.46543777
110positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.46299731
111positive regulation of mast cell degranulation (GO:0043306)2.45867834
112positive regulation of mast cell activation involved in immune response (GO:0033008)2.45867834
113hypotonic response (GO:0006971)2.45399787
114dendritic cell migration (GO:0036336)2.45121947
115epithelial cell-cell adhesion (GO:0090136)2.44948540
116glomerular visceral epithelial cell development (GO:0072015)2.44720669
117positive regulation of endothelial cell apoptotic process (GO:2000353)2.44184657
118defense response to protozoan (GO:0042832)2.43254723
119interferon-gamma-mediated signaling pathway (GO:0060333)2.42548663
120positive regulation of monocyte chemotaxis (GO:0090026)2.41750509
121regulation of T cell tolerance induction (GO:0002664)2.41376270
122hepatocyte apoptotic process (GO:0097284)2.41002294
123cellular response to thyroid hormone stimulus (GO:0097067)2.40849822
124reactive oxygen species biosynthetic process (GO:1903409)2.40584360
125neutrophil migration (GO:1990266)2.40050979
126positive regulation of toll-like receptor signaling pathway (GO:0034123)2.39731513
127negative regulation of phagocytosis (GO:0050765)2.38713309
128microglial cell activation (GO:0001774)2.38233827
129macrophage activation (GO:0042116)2.37929160
130renal filtration (GO:0097205)2.35179010
131positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.34596518
132regulation of mononuclear cell migration (GO:0071675)2.34316097
133regulation of macrophage cytokine production (GO:0010935)2.32376952
134positive regulation of p38MAPK cascade (GO:1900745)2.32110717
135regulation of interferon-beta production (GO:0032648)2.31945234
136lymphangiogenesis (GO:0001946)2.31908412
137glomerular basement membrane development (GO:0032836)2.30065498
138positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.27982021
139hyaluronan catabolic process (GO:0030214)2.27849774
140response to type I interferon (GO:0034340)2.27042999
141response to interferon-alpha (GO:0035455)2.26597090
142pinocytosis (GO:0006907)2.26476464
143B cell mediated immunity (GO:0019724)2.26365021
144regulation of vitamin D biosynthetic process (GO:0060556)2.25837108
145positive regulation of interleukin-6 production (GO:0032755)2.25618067
146endothelial tube morphogenesis (GO:0061154)2.25593169
147morphogenesis of an endothelium (GO:0003159)2.25593169
148barbed-end actin filament capping (GO:0051016)2.25092075
149negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.24913397
150positive regulation of macrophage cytokine production (GO:0060907)2.23375443
151cellular response to zinc ion (GO:0071294)2.22584970
152positive regulation of SMAD protein import into nucleus (GO:0060391)2.22020080
153regulation of cholesterol storage (GO:0010885)2.21006187
154adhesion of symbiont to host (GO:0044406)2.21001543
155actin nucleation (GO:0045010)2.20582895
156regulation of endothelial cell differentiation (GO:0045601)2.20532795
157dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.20488448
158regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.20283122
159positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.20078357
160maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.19059660
161glomerular filtration (GO:0003094)2.18444960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.96352774
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.80095201
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.75939659
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.54707256
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.54368013
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.50589575
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.29347895
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.03669299
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.76371773
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.73324886
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.66273299
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.40705978
13* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36845748
14* IRF8_27001747_Chip-Seq_BMDM_Mouse2.33346606
15HIF1A_21447827_ChIP-Seq_MCF-7_Human2.27051768
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.25863275
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.21627371
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.17614516
19E2F7_22180533_ChIP-Seq_HELA_Human2.16270502
20* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15937649
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.14989355
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.13119344
23CLOCK_20551151_ChIP-Seq_293T_Human2.06058559
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.03788587
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.01589365
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.99778798
27* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89181814
28SCL_19346495_ChIP-Seq_HPC-7_Human1.88951520
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.85476904
30SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.83390220
31SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.83390220
32* GATA2_21666600_ChIP-Seq_HMVEC_Human1.83243241
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.80107332
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.77290181
35CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.73818587
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.72931118
37RUNX_20019798_ChIP-Seq_JUKART_Human1.72239268
38SALL4_18804426_ChIP-ChIP_XEN_Mouse1.70845096
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68543292
40* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62460809
41ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.61949556
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.61018006
43SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59410123
44* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59127729
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.59030153
46* SOX2_20726797_ChIP-Seq_SW620_Human1.57384426
47* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50606997
48MAF_26560356_Chip-Seq_TH1_Human1.49192709
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48989369
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47738116
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46870436
52CJUN_26792858_Chip-Seq_BT549_Human1.46825427
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.46757245
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.44191931
55* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40223638
56* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40138837
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38842585
58MYB_26560356_Chip-Seq_TH2_Human1.38528710
59TCF7_22412390_ChIP-Seq_EML_Mouse1.37866475
60* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37718172
61* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35562226
62* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35265653
63CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34945637
64CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.34453677
65* GATA1_19941827_ChIP-Seq_MEL_Mouse1.34340650
66* SPI1_23547873_ChIP-Seq_NB4_Human1.32501169
67* BRD4_25478319_ChIP-Seq_HGPS_Human1.31018117
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30971698
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29692921
70FOXM1_23109430_ChIP-Seq_U2OS_Human1.29590840
71GATA1_19941826_ChIP-Seq_K562_Human1.29084398
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.26782625
73PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26363803
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25289569
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25281624
76* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24891053
77NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24633683
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23246881
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22535942
80STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.22505126
81* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21200993
82EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.20760380
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20553069
84MYB_26560356_Chip-Seq_TH1_Human1.20152955
85KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19002257
86KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19002257
87KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19002257
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18866605
89UTX_26944678_Chip-Seq_JUKART_Human1.17597533
90* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.16831525
91ATF3_27146783_Chip-Seq_COLON_Human1.15686177
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14608182
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13283079
94EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11748714
95VDR_24787735_ChIP-Seq_THP-1_Human1.11529430
96WT1_19549856_ChIP-ChIP_CCG9911_Human1.11204345
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10981889
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10881044
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10370414
100* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09489204
101* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09442484
102VDR_24763502_ChIP-Seq_THP-1_Human1.09261088
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09240904
104* CDX2_20551321_ChIP-Seq_CACO-2_Human1.08689913
105GATA2_19941826_ChIP-Seq_K562_Human1.08529594
106* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08080904
107CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07708926
108TFEB_21752829_ChIP-Seq_HELA_Human1.07490333
109STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07005916
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06910498
111UBF1/2_26484160_Chip-Seq_HMECs_Human1.06058050
112KDM2B_26808549_Chip-Seq_DND41_Human1.05787643
113AR_21909140_ChIP-Seq_LNCAP_Human1.05689100
114* RACK7_27058665_Chip-Seq_MCF-7_Human1.05501326
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04183344
116GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04139409
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03770947
118* PU_27001747_Chip-Seq_BMDM_Mouse1.02495131
119CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01706336
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01589238
121SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01020586
122* SPI1_23127762_ChIP-Seq_K562_Human1.00718430
123GATA1_22025678_ChIP-Seq_K562_Human1.00663332
124CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00408894
125RUNX1_22412390_ChIP-Seq_EML_Mouse0.99214426
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98934733
127NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98934733
128CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98602516
129ESR1_20079471_ChIP-ChIP_T-47D_Human0.98181144
130FOXO3_23340844_ChIP-Seq_DLD1_Human0.97984770
131* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96663659
132CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96054640
133P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93709963
134TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93545667
135* LXR_22292898_ChIP-Seq_THP-1_Human0.93125069
136FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92492971
137GATA4_25053715_ChIP-Seq_YYC3_Human0.91096052
138TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90775560
139ELK1_22589737_ChIP-Seq_MCF10A_Human0.90342330
140NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88584654
141* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88038390
142VDR_21846776_ChIP-Seq_THP-1_Human0.87751138
143* NCOR1_26117541_ChIP-Seq_K562_Human0.87291905
144SOX2_27498859_Chip-Seq_STOMACH_Mouse0.85275118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.38891675
2MP0004272_abnormal_basement_membrane2.75422270
3MP0003705_abnormal_hypodermis_morpholog2.71287845
4MP0008260_abnormal_autophagy2.70466925
5MP0003566_abnormal_cell_adhesion2.59795818
6MP0006054_spinal_hemorrhage2.53493256
7MP0000465_gastrointestinal_hemorrhage2.39775115
8MP0010352_gastrointestinal_tract_polyps2.34853669
9MP0003279_aneurysm2.21545114
10MP0003436_decreased_susceptibility_to2.20529082
11MP0005167_abnormal_blood-brain_barrier1.99798705
12MP0010368_abnormal_lymphatic_system1.90506058
13MP0002148_abnormal_hypersensitivity_rea1.86384879
14MP0001879_abnormal_lymphatic_vessel1.85352288
15MP0003724_increased_susceptibility_to1.85081632
16MP0005023_abnormal_wound_healing1.82811214
17MP0000343_altered_response_to1.82282848
18MP0005275_abnormal_skin_tensile1.82236032
19MP0009785_altered_susceptibility_to1.81031113
20MP0001835_abnormal_antigen_presentation1.80589959
21MP0003303_peritoneal_inflammation1.75752823
22MP0003075_altered_response_to1.74885624
23MP0000767_abnormal_smooth_muscle1.74090392
24MP0001958_emphysema1.73698589
25MP0001800_abnormal_humoral_immune1.73303504
26MP0003828_pulmonary_edema1.71293381
27MP0009278_abnormal_bone_marrow1.71142401
28MP0005451_abnormal_body_composition1.68048051
29MP0001533_abnormal_skeleton_physiology1.66360999
30MP0003941_abnormal_skin_development1.64359112
31MP0002419_abnormal_innate_immunity1.63476465
32MP0005058_abnormal_lysosome_morphology1.60476823
33MP0000858_altered_metastatic_potential1.55570527
34MP0005503_abnormal_tendon_morphology1.55260261
35MP0003091_abnormal_cell_migration1.51977941
36MP0003183_abnormal_peptide_metabolism1.50924835
37MP0005076_abnormal_cell_differentiation1.50039303
38MP0003448_altered_tumor_morphology1.48528356
39MP0004782_abnormal_surfactant_physiolog1.42570430
40MP0003172_abnormal_lysosome_physiology1.42320713
41MP0003191_abnormal_cellular_cholesterol1.41207647
42MP0005671_abnormal_response_to1.40107749
43MP0005165_increased_susceptibility_to1.37554573
44MP0002877_abnormal_melanocyte_morpholog1.35993372
45MP0001851_eye_inflammation1.35025000
46MP0005623_abnormal_meninges_morphology1.34388944
47MP0002132_abnormal_respiratory_system1.33057337
48MP0005025_abnormal_response_to1.27461536
49MP0006082_CNS_inflammation1.27287359
50MP0005166_decreased_susceptibility_to1.26344700
51MP0005390_skeleton_phenotype1.25811029
52MP0003385_abnormal_body_wall1.25704956
53MP0008004_abnormal_stomach_pH1.23214906
54MP0005164_abnormal_response_to1.21779413
55MP0005000_abnormal_immune_tolerance1.21652755
56MP0008469_abnormal_protein_level1.20866422
57MP0003300_gastrointestinal_ulcer1.20552251
58MP0004883_abnormal_blood_vessel1.14680779
59MP0000716_abnormal_immune_system1.13282852
60MP0002998_abnormal_bone_remodeling1.12113377
61MP0001915_intracranial_hemorrhage1.11424278
62MP0002452_abnormal_antigen_presenting1.10239688
63MP0009840_abnormal_foam_cell1.09186512
64MP0010234_abnormal_vibrissa_follicle1.08719391
65MP0004510_myositis1.08062044
66MP0001542_abnormal_bone_strength1.07916649
67MP0002398_abnormal_bone_marrow1.07094145
68MP0002295_abnormal_pulmonary_circulatio1.06891161
69MP0002405_respiratory_system_inflammati1.06832028
70MP0005397_hematopoietic_system_phenotyp1.06618537
71MP0001545_abnormal_hematopoietic_system1.06618537
72MP0004084_abnormal_cardiac_muscle1.06053134
73MP0009053_abnormal_anal_canal1.04928434
74MP0000604_amyloidosis1.04649311
75MP0003315_abnormal_perineum_morphology1.03478796
76MP0002332_abnormal_exercise_endurance1.02841628
77MP0004947_skin_inflammation1.01997696
78MP0010307_abnormal_tumor_latency1.01565435
79MP0005367_renal/urinary_system_phenotyp1.01424187
80MP0000516_abnormal_urinary_system1.01424187
81MP0005508_abnormal_skeleton_morphology0.99822398
82MP0000685_abnormal_immune_system0.96607803
83MP0002138_abnormal_hepatobiliary_system0.96355221
84MP0000249_abnormal_blood_vessel0.96141863
85MP0001790_abnormal_immune_system0.95726400
86MP0005387_immune_system_phenotype0.95726400
87MP0002429_abnormal_blood_cell0.94856816
88MP0001614_abnormal_blood_vessel0.94359569
89MP0010155_abnormal_intestine_physiology0.92908608
90MP0005464_abnormal_platelet_physiology0.92131935
91MP0005257_abnormal_intraocular_pressure0.91314379
92MP0000750_abnormal_muscle_regeneration0.91047528
93MP0004484_altered_response_of0.90400289
94MP0002166_altered_tumor_susceptibility0.90343582
95MP0000733_abnormal_muscle_development0.90014663
96MP0003806_abnormal_nucleotide_metabolis0.89322475
97MP0001845_abnormal_inflammatory_respons0.89278486
98MP0003690_abnormal_glial_cell0.88247834
99MP0001853_heart_inflammation0.86810590
100MP0003950_abnormal_plasma_membrane0.86748390
101MP0003453_abnormal_keratinocyte_physiol0.86405360
102MP0005409_darkened_coat_color0.86173229
103MP0002128_abnormal_blood_circulation0.86109188
104MP0002925_abnormal_cardiovascular_devel0.85648283
105MP0002722_abnormal_immune_system0.84627302
106MP0002006_tumorigenesis0.84322954
107MP0001175_abnormal_lung_morphology0.84245718
108MP0010030_abnormal_orbit_morphology0.83851863
109MP0005310_abnormal_salivary_gland0.83658978
110MP0008007_abnormal_cellular_replicative0.83417026
111MP0002282_abnormal_trachea_morphology0.82774294
112MP0009333_abnormal_splenocyte_physiolog0.82391033
113MP0001819_abnormal_immune_cell0.82026690
114MP0009763_increased_sensitivity_to0.80673734
115MP0003795_abnormal_bone_structure0.80505935
116MP0003045_fibrosis0.80390089
117MP0000689_abnormal_spleen_morphology0.80270163
118MP0002060_abnormal_skin_morphology0.79667504
119MP0009764_decreased_sensitivity_to0.79231484
120MP0002420_abnormal_adaptive_immunity0.78454889
121MP0003866_abnormal_defecation0.78198078
122MP0002088_abnormal_embryonic_growth/wei0.78069477
123MP0003984_embryonic_growth_retardation0.77779299
124MP0008874_decreased_physiological_sensi0.77669297
125MP0000490_abnormal_crypts_of0.77617702
126MP0005171_absent_coat_pigmentation0.77054174
127MP0003221_abnormal_cardiomyocyte_apopto0.76441826
128MP0003656_abnormal_erythrocyte_physiolo0.76410441
129MP0003186_abnormal_redox_activity0.76241533
130MP0001849_ear_inflammation0.76163330
131MP0003878_abnormal_ear_physiology0.75863952
132MP0005377_hearing/vestibular/ear_phenot0.75863952
133MP0002723_abnormal_immune_serum0.75527715
134MP0002086_abnormal_extraembryonic_tissu0.75348792
135MP0004808_abnormal_hematopoietic_stem0.75000672
136MP0010630_abnormal_cardiac_muscle0.74801597
137MP0004264_abnormal_extraembryonic_tissu0.74627576
138MP0003115_abnormal_respiratory_system0.74111418
139MP0003763_abnormal_thymus_physiology0.72768589

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.29940506
2Recurrent abscess formation (HP:0002722)4.21433578
3Protrusio acetabuli (HP:0003179)3.88214746
4Retrobulbar optic neuritis (HP:0100654)3.77508300
5Optic neuritis (HP:0100653)3.77508300
6Premature rupture of membranes (HP:0001788)3.76688839
7Recurrent bacterial skin infections (HP:0005406)3.57039882
8Vertebral compression fractures (HP:0002953)3.26309533
9Cerebral aneurysm (HP:0004944)3.25699339
10Cervical subluxation (HP:0003308)3.20477855
11Recurrent gram-negative bacterial infections (HP:0005420)3.09599657
12Amyloidosis (HP:0011034)3.00040866
13Aortic aneurysm (HP:0004942)2.92365224
14Keratoconjunctivitis sicca (HP:0001097)2.91232197
15Systemic lupus erythematosus (HP:0002725)2.89022507
16Obstructive lung disease (HP:0006536)2.86710554
17Chronic obstructive pulmonary disease (HP:0006510)2.86710554
18Stomatitis (HP:0010280)2.85611211
19Vacuolated lymphocytes (HP:0001922)2.84589674
20Gastrointestinal infarctions (HP:0005244)2.83294398
21Prolonged bleeding time (HP:0003010)2.82054311
22Recurrent skin infections (HP:0001581)2.79135156
23Osteolytic defects of the phalanges of the hand (HP:0009771)2.73972733
24Osteolytic defects of the hand bones (HP:0009699)2.73972733
25Aortic dissection (HP:0002647)2.73620254
26Hematochezia (HP:0002573)2.73574217
27Gingival bleeding (HP:0000225)2.73537077
28Abnormality of macrophages (HP:0004311)2.65841225
29Atrophic scars (HP:0001075)2.64077697
30Epistaxis (HP:0000421)2.60559008
31Keratoconjunctivitis (HP:0001096)2.59079336
32Metaphyseal cupping (HP:0003021)2.58628761
33Autoimmune thrombocytopenia (HP:0001973)2.56911880
34Muscle fibrillation (HP:0010546)2.55671132
35Cupped ribs (HP:0000887)2.54810013
36Recurrent fungal infections (HP:0002841)2.53185758
37Petechiae (HP:0000967)2.43998975
38Mediastinal lymphadenopathy (HP:0100721)2.43903851
39Abnormal platelet volume (HP:0011876)2.43742421
40Bilateral sensorineural hearing impairment (HP:0008619)2.42934244
41Nonimmune hydrops fetalis (HP:0001790)2.42314101
42Episodic fever (HP:0001954)2.42267536
43Vasculitis (HP:0002633)2.41511154
44Pulmonary infiltrates (HP:0002113)2.41496418
45Peritonitis (HP:0002586)2.39943534
46Meningitis (HP:0001287)2.39523612
47Chest pain (HP:0100749)2.37158417
48Hemoptysis (HP:0002105)2.36866780
49Increased connective tissue (HP:0009025)2.36050607
50Right ventricular cardiomyopathy (HP:0011663)2.35439609
51Shallow orbits (HP:0000586)2.34632827
52Abnormality of the nasal mucosa (HP:0000433)2.33793590
53Increased IgE level (HP:0003212)2.32401846
54Abnormality of the peritoneum (HP:0002585)2.32368735
55Abnormal delayed hypersensitivity skin test (HP:0002963)2.31180183
56Purpura (HP:0000979)2.31016758
57Tongue fasciculations (HP:0001308)2.28754505
58Gingivitis (HP:0000230)2.28584504
59Loss of speech (HP:0002371)2.28347832
60Increased cerebral lipofuscin (HP:0011813)2.27971693
61Increased IgM level (HP:0003496)2.27617977
62Subacute progressive viral hepatitis (HP:0006572)2.26638149
63Syringomyelia (HP:0003396)2.24443616
64Spinal cord lesions (HP:0100561)2.24443616
65Tetraparesis (HP:0002273)2.23632515
66Hepatosplenomegaly (HP:0001433)2.19616658
67Increased neuronal autofluorescent lipopigment (HP:0002074)2.19576757
68Blue sclerae (HP:0000592)2.18622475
69Interstitial pulmonary disease (HP:0006530)2.17283265
70Vascular tortuosity (HP:0004948)2.16066386
71Hypergammaglobulinemia (HP:0010702)2.14501926
72Encephalitis (HP:0002383)2.13816655
73Recurrent cutaneous fungal infections (HP:0011370)2.13426322
74Chronic mucocutaneous candidiasis (HP:0002728)2.13426322
75Polycythemia (HP:0001901)2.11658922
76Segmental peripheral demyelination/remyelination (HP:0003481)2.10812479
77Spinal rigidity (HP:0003306)2.10526404
78Ankle contracture (HP:0006466)2.09628927
79Thin bony cortex (HP:0002753)2.09142871
80Pulmonary embolism (HP:0002204)2.08961545
81Dilatation of the ascending aorta (HP:0005111)2.08007693
82Micronodular cirrhosis (HP:0001413)2.07336376
83Abnormal platelet function (HP:0011869)2.05691779
84Impaired platelet aggregation (HP:0003540)2.05691779
85Abnormality of the vasculature of the conjunctiva (HP:0008054)2.04718112
86Increased mean platelet volume (HP:0011877)2.04403397
87Wormian bones (HP:0002645)2.03401828
88Orchitis (HP:0100796)2.03069400
89Alopecia of scalp (HP:0002293)2.00877159
90Asymmetry of the thorax (HP:0001555)2.00841831
91Breech presentation (HP:0001623)2.00531526
92Esophageal varix (HP:0002040)1.98967450
93Distal lower limb muscle weakness (HP:0009053)1.98860462
94Myositis (HP:0100614)1.94336813
95Soft skin (HP:0000977)1.93834125
96Conjunctival telangiectasia (HP:0000524)1.93467742
97Menorrhagia (HP:0000132)1.93456685
98Glomerulopathy (HP:0100820)1.92422007
99Dysostosis multiplex (HP:0000943)1.92029222
100Polygenic inheritance (HP:0010982)1.91297903
101Recurrent viral infections (HP:0004429)1.91035077
102Leukocytosis (HP:0001974)1.90274402
103Short nail (HP:0001799)1.90233876
104Arterial tortuosity (HP:0005116)1.89755924
105Anorexia (HP:0002039)1.89638977
106Elevated erythrocyte sedimentation rate (HP:0003565)1.89151982
107Wrist flexion contracture (HP:0001239)1.88857839
108Hemorrhage of the eye (HP:0011885)1.88657487
109Platyspondyly (HP:0000926)1.87978538
110Premature loss of primary teeth (HP:0006323)1.87956426
111Spondylolisthesis (HP:0003302)1.87632018
112Coxa vara (HP:0002812)1.85387585
113Abnormality of polysaccharide metabolism (HP:0011012)1.83849830
114Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83849830
115Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83849830
116Nephritis (HP:0000123)1.83685392
117Glomerulonephritis (HP:0000099)1.82822784
118Abnormality of the distal phalanges of the toes (HP:0010182)1.82686786
119Abnormality of T cell number (HP:0011839)1.81521375
120Skin ulcer (HP:0200042)1.80087783
121Thick nail (HP:0001805)1.79399295
122Follicular hyperkeratosis (HP:0007502)1.78027541
123Pathologic fracture (HP:0002756)1.77792171
124Gangrene (HP:0100758)1.77235823
125Viral hepatitis (HP:0006562)1.76607745
126Periodontitis (HP:0000704)1.76172487
127Ovoid vertebral bodies (HP:0003300)1.75754588
128Lymphangioma (HP:0100764)1.75036485
129Cellulitis (HP:0100658)1.73786694
130Urinary glycosaminoglycan excretion (HP:0003541)1.72348288
131Mucopolysacchariduria (HP:0008155)1.72348288
132Pulmonary artery stenosis (HP:0004415)1.71546942
133Prostate neoplasm (HP:0100787)1.69232440
134Hand muscle atrophy (HP:0009130)1.68830815
135Aneurysm (HP:0002617)1.68250360
136Axonal loss (HP:0003447)1.65205259
137Basal ganglia calcification (HP:0002135)1.65164586
138Biconcave vertebral bodies (HP:0004586)1.64568479
139Myocardial infarction (HP:0001658)1.64440810
140Arterial thrombosis (HP:0004420)1.63395655
141Fused cervical vertebrae (HP:0002949)1.62754521
142Urticaria (HP:0001025)1.62053491
143Pustule (HP:0200039)1.61449818
144Ventricular tachycardia (HP:0004756)1.61443476
145Osteomyelitis (HP:0002754)1.61396895
146Bicuspid aortic valve (HP:0001647)1.61389370
147Mucosal telangiectasiae (HP:0100579)1.60641823
148Abnormality of dentin (HP:0010299)1.59984472
149Abnormality of liposaccharide metabolism (HP:0010968)1.59194283
150Abnormality of glycosphingolipid metabolism (HP:0004343)1.59194283
151Abnormality of glycolipid metabolism (HP:0010969)1.59194283
152Persistence of primary teeth (HP:0006335)1.58866837
153Abnormality of the acetabulum (HP:0003170)1.58353239
154Fragile skin (HP:0001030)1.57867597
155Spontaneous hematomas (HP:0007420)1.55474626
156Camptodactyly of toe (HP:0001836)1.55242662

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TBK13.59672869
2MAP3K142.70816931
3PIM22.53902653
4TESK12.52151771
5KDR2.52026025
6TGFBR22.42247701
7FES2.18681458
8EPHA22.14578734
9ERN12.10684544
10PRPF4B2.02512534
11PKN21.95675225
12TIE11.95053052
13TRIB31.86945152
14MAP3K31.83718047
15IKBKE1.82215253
16FGR1.78964575
17PAK41.77442141
18NEK91.75748741
19TTN1.72515469
20SIK31.72415757
21ERBB31.71569252
22MYLK1.71297675
23MAP4K11.70933368
24TGFBR11.67865989
25ZAK1.63912172
26RIPK11.62969112
27STK101.60816892
28IKBKB1.53538466
29BLK1.52482058
30MAP2K31.51016311
31MAP3K131.50674188
32TRPM71.47284121
33KSR21.46128942
34EPHB21.45080531
35IRAK41.43659959
36BMPR21.38402140
37MAP3K121.38186866
38PBK1.35091176
39MAP3K11.34462788
40RPS6KA41.32609906
41MAP3K111.28940030
42HCK1.28844368
43FRK1.26958571
44PIM11.26244776
45LIMK11.22848674
46BMX1.18702215
47YES11.18700581
48PTK61.18344007
49MAP3K61.17348062
50PDK21.15630863
51DDR21.13218198
52GRK61.11675375
53MST41.10703227
54MAP3K21.10120276
55PRKG21.10079048
56TAOK11.09593848
57JAK21.09300801
58CSK1.08116516
59JAK31.07008673
60BTK1.06681645
61CHUK1.06548829
62LRRK21.06507924
63PTK21.06190525
64STK31.05516129
65TYK21.04510618
66NUAK11.04392664
67IRAK31.00528460
68PDGFRA1.00416941
69TAOK20.98794849
70STK38L0.97823113
71CLK10.93513044
72SYK0.93148657
73PTK2B0.91069738
74DMPK0.89033260
75IRAK10.87998807
76TEC0.85912726
77STK240.85659521
78IRAK20.85422961
79LYN0.84890572
80MST1R0.82812532
81KSR10.82607662
82MET0.80364801
83LATS20.79941263
84MAP3K80.78885590
85STK40.77171256
86EIF2AK20.75637179
87FER0.72940923
88MATK0.72562627
89LATS10.71294320
90EPHB10.71130468
91FLT30.70300761
92PDPK10.69316546
93SCYL20.68727017
94MAPKAPK20.67193490
95BMPR1B0.67039411
96PAK20.66139349
97ZAP700.66091951
98ABL20.65820089
99TNK20.65803762
100ILK0.65187729
101ARAF0.65083288
102LCK0.64459259
103NME20.64189601
104RIPK40.62696029
105RPS6KL10.60933420
106RPS6KC10.60933420
107FGFR40.60770155
108CDC42BPA0.58731885
109RPS6KA60.58078977
110MARK30.57791288
111ROCK20.54970147
112RAF10.54370336
113AKT30.54200008
114MAP3K50.53346316
115EIF2AK10.52791660
116RET0.52790356
117JAK10.52673770
118PDK10.52314971
119MARK20.52130610
120KIT0.51268303
121IGF1R0.49770093
122NEK10.49721981
123FYN0.47263420
124MAPK70.47222583
125CDK60.47113961
126FGFR30.46554363
127DAPK30.46378453
128EPHA30.46342895
129TESK20.45527962
130STK380.45256748
131PRKD20.44393707
132CDK80.43951551
133EIF2AK30.43684975
134CDK70.42604235
135PAK10.42076448
136MAPK120.41399598
137GRK70.41229387
138CSF1R0.40070925
139RPS6KB20.39976519
140CDK120.39707227
141PDGFRB0.39449649
142EGFR0.38999388
143MOS0.38021049
144ITK0.36797665
145SGK30.36241668
146PIK3CG0.33905255
147PRKCD0.33197699

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.67894119
2Legionellosis_Homo sapiens_hsa051342.45098306
3Malaria_Homo sapiens_hsa051442.33522902
4Pertussis_Homo sapiens_hsa051332.18214594
5Staphylococcus aureus infection_Homo sapiens_hsa051502.06392366
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.05026896
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.03326725
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.95170433
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.89752276
10Adherens junction_Homo sapiens_hsa045201.84550425
11Leukocyte transendothelial migration_Homo sapiens_hsa046701.79380610
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.75322300
13Salmonella infection_Homo sapiens_hsa051321.69945451
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.68475613
15Shigellosis_Homo sapiens_hsa051311.67379303
16Toxoplasmosis_Homo sapiens_hsa051451.67161191
17Phagosome_Homo sapiens_hsa041451.60605036
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59811631
19ECM-receptor interaction_Homo sapiens_hsa045121.59236020
20TNF signaling pathway_Homo sapiens_hsa046681.57944297
21Other glycan degradation_Homo sapiens_hsa005111.57231469
22Influenza A_Homo sapiens_hsa051641.55935088
23Tuberculosis_Homo sapiens_hsa051521.54356105
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54325806
25Osteoclast differentiation_Homo sapiens_hsa043801.53222494
26Focal adhesion_Homo sapiens_hsa045101.52608962
27Apoptosis_Homo sapiens_hsa042101.52537932
28Lysosome_Homo sapiens_hsa041421.51171449
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.50952127
30Measles_Homo sapiens_hsa051621.50002832
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.49779464
32Small cell lung cancer_Homo sapiens_hsa052221.46305293
33Viral myocarditis_Homo sapiens_hsa054161.45910221
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41907631
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.41379908
36Graft-versus-host disease_Homo sapiens_hsa053321.39596101
37Amoebiasis_Homo sapiens_hsa051461.37017205
38Autoimmune thyroid disease_Homo sapiens_hsa053201.36621670
39Rheumatoid arthritis_Homo sapiens_hsa053231.30712882
40Proteoglycans in cancer_Homo sapiens_hsa052051.26615357
41Herpes simplex infection_Homo sapiens_hsa051681.25670626
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22239676
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20868507
44Antigen processing and presentation_Homo sapiens_hsa046121.14576290
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13761255
46African trypanosomiasis_Homo sapiens_hsa051431.13508047
47Hepatitis B_Homo sapiens_hsa051611.13077573
48Renal cell carcinoma_Homo sapiens_hsa052111.12593583
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09447776
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07940812
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07881725
52p53 signaling pathway_Homo sapiens_hsa041151.07599945
53SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06696546
54VEGF signaling pathway_Homo sapiens_hsa043701.04436348
55Galactose metabolism_Homo sapiens_hsa000521.01716935
56Hepatitis C_Homo sapiens_hsa051601.00835130
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.00489964
58HIF-1 signaling pathway_Homo sapiens_hsa040661.00059552
59Hematopoietic cell lineage_Homo sapiens_hsa046400.98137346
60TGF-beta signaling pathway_Homo sapiens_hsa043500.96505303
61Mineral absorption_Homo sapiens_hsa049780.96142535
62Non-small cell lung cancer_Homo sapiens_hsa052230.96110906
63Chronic myeloid leukemia_Homo sapiens_hsa052200.93418430
64Viral carcinogenesis_Homo sapiens_hsa052030.92990121
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90643455
66MicroRNAs in cancer_Homo sapiens_hsa052060.90300228
67Asthma_Homo sapiens_hsa053100.89852456
68Proteasome_Homo sapiens_hsa030500.88924336
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.82207049
70Hippo signaling pathway_Homo sapiens_hsa043900.81557574
71Bladder cancer_Homo sapiens_hsa052190.81289051
72HTLV-I infection_Homo sapiens_hsa051660.81122775
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79485256
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.79066383
75Tight junction_Homo sapiens_hsa045300.78685361
76Allograft rejection_Homo sapiens_hsa053300.77624940
77T cell receptor signaling pathway_Homo sapiens_hsa046600.77528903
78Epstein-Barr virus infection_Homo sapiens_hsa051690.76493405
79Prolactin signaling pathway_Homo sapiens_hsa049170.76344464
80PI3K-Akt signaling pathway_Homo sapiens_hsa041510.75499211
81Dorso-ventral axis formation_Homo sapiens_hsa043200.73618555
82Dilated cardiomyopathy_Homo sapiens_hsa054140.73120605
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.72449141
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71257554
85Complement and coagulation cascades_Homo sapiens_hsa046100.69929185
86Platelet activation_Homo sapiens_hsa046110.68999161
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68702391
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67477427
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67077237
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66875974
91* Phospholipase D signaling pathway_Homo sapiens_hsa040720.63094553
92Chemokine signaling pathway_Homo sapiens_hsa040620.60691710
93GnRH signaling pathway_Homo sapiens_hsa049120.60291599
94Notch signaling pathway_Homo sapiens_hsa043300.59026800
95Endometrial cancer_Homo sapiens_hsa052130.58743895
96Melanoma_Homo sapiens_hsa052180.58622571
97Fructose and mannose metabolism_Homo sapiens_hsa000510.58197487
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57555400
99Acute myeloid leukemia_Homo sapiens_hsa052210.56380722
100* Pathways in cancer_Homo sapiens_hsa052000.56358311
101Arachidonic acid metabolism_Homo sapiens_hsa005900.56288453
102Renin-angiotensin system_Homo sapiens_hsa046140.56287929
103Prostate cancer_Homo sapiens_hsa052150.55485713
104* Pancreatic cancer_Homo sapiens_hsa052120.53976816
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.53145629
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.53046596
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52651405
108Type I diabetes mellitus_Homo sapiens_hsa049400.50882635
109Protein digestion and absorption_Homo sapiens_hsa049740.50660883
110Choline metabolism in cancer_Homo sapiens_hsa052310.48247173
111Cell cycle_Homo sapiens_hsa041100.47263780
112Prion diseases_Homo sapiens_hsa050200.46510596
113Glioma_Homo sapiens_hsa052140.46400371
114* Rap1 signaling pathway_Homo sapiens_hsa040150.46128619
115Pentose phosphate pathway_Homo sapiens_hsa000300.45518500
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.43804522
117ErbB signaling pathway_Homo sapiens_hsa040120.42416992
118Insulin resistance_Homo sapiens_hsa049310.41698294
119Endocytosis_Homo sapiens_hsa041440.41260140
120Estrogen signaling pathway_Homo sapiens_hsa049150.40874748
121Vibrio cholerae infection_Homo sapiens_hsa051100.39531111
122Primary immunodeficiency_Homo sapiens_hsa053400.37765860
123Sphingolipid metabolism_Homo sapiens_hsa006000.37401075
124B cell receptor signaling pathway_Homo sapiens_hsa046620.37323657
125Base excision repair_Homo sapiens_hsa034100.34347891
126FoxO signaling pathway_Homo sapiens_hsa040680.34320055
127Thyroid cancer_Homo sapiens_hsa052160.33687333

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