RALBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)4.67493275
2mitotic chromosome condensation (GO:0007076)4.58672620
3attachment of spindle microtubules to kinetochore (GO:0008608)4.45495559
4mitotic metaphase plate congression (GO:0007080)4.28269664
5histone H2A monoubiquitination (GO:0035518)4.21334721
6hypotonic response (GO:0006971)4.11613078
7nuclear pore complex assembly (GO:0051292)4.07953937
8desmosome organization (GO:0002934)3.96700872
9regulation of female gonad development (GO:2000194)3.91767167
10regulation of histone H3-K27 methylation (GO:0061085)3.81201932
11regulation of sister chromatid cohesion (GO:0007063)3.79830440
12protein localization to kinetochore (GO:0034501)3.75057731
13focal adhesion assembly (GO:0048041)3.74451600
14cell-substrate adherens junction assembly (GO:0007045)3.74451600
15intestinal epithelial cell development (GO:0060576)3.68951050
16regulation of mitotic spindle organization (GO:0060236)3.65843388
17metaphase plate congression (GO:0051310)3.62570687
18histone H2A ubiquitination (GO:0033522)3.53124493
19protein localization to chromosome, centromeric region (GO:0071459)3.51536623
20negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.51431259
21regulation of RNA export from nucleus (GO:0046831)3.50439962
22regulation of spindle organization (GO:0090224)3.48470458
23positive regulation of receptor recycling (GO:0001921)3.45093801
24regulation of nucleobase-containing compound transport (GO:0032239)3.39830859
25interferon-gamma secretion (GO:0072643)3.37168844
26female gamete generation (GO:0007292)3.36770030
27viral transcription (GO:0019083)3.35411473
28skin morphogenesis (GO:0043589)3.34503321
29DNA damage induced protein phosphorylation (GO:0006975)3.33232119
30adherens junction assembly (GO:0034333)3.32901858
31mitotic sister chromatid segregation (GO:0000070)3.32396417
32negative regulation of erythrocyte differentiation (GO:0045647)3.32058354
33pinocytosis (GO:0006907)3.29049832
34DNA unwinding involved in DNA replication (GO:0006268)3.26011431
35establishment of chromosome localization (GO:0051303)3.25511792
36meiotic cell cycle (GO:0051321)3.23831951
37translational termination (GO:0006415)3.23622136
38nuclear pore organization (GO:0006999)3.14138943
39negative regulation of histone methylation (GO:0031061)3.12971954
40regulation of keratinocyte differentiation (GO:0045616)3.08709340
41barbed-end actin filament capping (GO:0051016)3.08507648
42activation of Rac GTPase activity (GO:0032863)3.04934137
43hepatocyte apoptotic process (GO:0097284)3.03733227
44piRNA metabolic process (GO:0034587)3.02759582
45sister chromatid segregation (GO:0000819)3.02587498
46positive regulation of keratinocyte differentiation (GO:0045618)3.02033072
47* positive regulation of Cdc42 GTPase activity (GO:0043089)3.01408209
48negative regulation of protein localization to plasma membrane (GO:1903077)3.01371112
49regulation of glucocorticoid metabolic process (GO:0031943)3.00412775
50trophectodermal cell differentiation (GO:0001829)2.99744928
51regulation of meiosis (GO:0040020)2.98394570
52establishment of skin barrier (GO:0061436)2.95342134
53positive regulation of chromosome segregation (GO:0051984)2.90304721
54embryonic process involved in female pregnancy (GO:0060136)2.88543729
55meiotic chromosome segregation (GO:0045132)2.88154504
56bundle of His cell to Purkinje myocyte communication (GO:0086069)2.87134514
57regulation of exit from mitosis (GO:0007096)2.86002617
58regulation of DNA methylation (GO:0044030)2.85811449
59regulation of retinoic acid receptor signaling pathway (GO:0048385)2.84686605
60regulation of early endosome to late endosome transport (GO:2000641)2.82991870
61positive regulation of megakaryocyte differentiation (GO:0045654)2.82467796
62negative regulation of meiosis (GO:0045835)2.81986693
63pore complex assembly (GO:0046931)2.81623923
64protein localization to endosome (GO:0036010)2.81439726
65cytoskeletal anchoring at plasma membrane (GO:0007016)2.80859945
66cortical actin cytoskeleton organization (GO:0030866)2.80639437
67regulation of hippo signaling (GO:0035330)2.80373476
68regulation of water loss via skin (GO:0033561)2.80372246
69negative regulation of necroptotic process (GO:0060546)2.80023747
70keratinocyte differentiation (GO:0030216)2.79230073
71regulation of transforming growth factor beta2 production (GO:0032909)2.77757040
72mitotic sister chromatid cohesion (GO:0007064)2.76515493
73negative regulation of hormone metabolic process (GO:0032351)2.76513433
74negative regulation of hormone biosynthetic process (GO:0032353)2.76513433
75protein localization to chromosome (GO:0034502)2.76336225
76translational elongation (GO:0006414)2.75667590
77nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.75242848
78modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.74490641
79positive regulation by organism of defense response of other organism involved in symbiotic interact2.74490641
80modulation by symbiont of host immune response (GO:0052553)2.74490641
81positive regulation by symbiont of host defense response (GO:0052509)2.74490641
82modulation by symbiont of host defense response (GO:0052031)2.74490641
83modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.74490641
84cytoplasmic mRNA processing body assembly (GO:0033962)2.74226928
85DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.73325309
86regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.71947294
87gene silencing by RNA (GO:0031047)2.71256355
88positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.69876441
89positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.69876441
90positive regulation of mitotic sister chromatid separation (GO:1901970)2.69876441
91histone H2B ubiquitination (GO:0033523)2.69528100
92negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.69318294
93negative regulation of smooth muscle cell differentiation (GO:0051151)2.69315016
94membrane raft organization (GO:0031579)2.65297989
95negative regulation of meiotic cell cycle (GO:0051447)2.65119655
96sphingosine metabolic process (GO:0006670)2.64600094
97protein K6-linked ubiquitination (GO:0085020)2.64100412
98stress fiber assembly (GO:0043149)2.63511019
99regulation of necroptotic process (GO:0060544)2.62551419
100mitotic nuclear envelope disassembly (GO:0007077)2.62127084
101columnar/cuboidal epithelial cell development (GO:0002066)2.62016757
102oocyte development (GO:0048599)2.61742059
103maturation of SSU-rRNA (GO:0030490)2.61543681
104oocyte maturation (GO:0001556)2.60836676
105nuclear envelope disassembly (GO:0051081)2.59632997
106membrane disassembly (GO:0030397)2.59632997
107SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.58622447
108cell-substrate junction assembly (GO:0007044)2.58614791
109formation of translation preinitiation complex (GO:0001731)2.58244148
110notochord development (GO:0030903)2.57731306
111viral life cycle (GO:0019058)2.56853966
112ribosomal small subunit biogenesis (GO:0042274)2.56148264
113negative regulation of stress fiber assembly (GO:0051497)2.56060360
114maturation of 5.8S rRNA (GO:0000460)2.55885200
115protein targeting to ER (GO:0045047)2.55769762
116cellular hyperosmotic response (GO:0071474)2.55265557
117myoblast migration (GO:0051451)2.54654610
118regulation of epidermis development (GO:0045682)2.52361155
119establishment of spindle localization (GO:0051293)2.52142936
120tight junction assembly (GO:0070830)2.51769930
121nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.51475116
122cotranslational protein targeting to membrane (GO:0006613)2.51175864
123protein localization to microtubule (GO:0035372)2.51117274
124mammary gland epithelial cell proliferation (GO:0033598)2.50668602
125chromosome segregation (GO:0007059)2.48513932
126establishment of protein localization to endoplasmic reticulum (GO:0072599)2.48004316
127positive regulation of lamellipodium assembly (GO:0010592)2.47853325
128translational initiation (GO:0006413)2.47445824
129chromatin assembly or disassembly (GO:0006333)2.47175263
130protein export from nucleus (GO:0006611)2.46985238
131membrane budding (GO:0006900)2.46368374
132diol metabolic process (GO:0034311)2.44751948
133ribosomal small subunit assembly (GO:0000028)2.44289251
134RNA stabilization (GO:0043489)2.44056232
135mRNA stabilization (GO:0048255)2.44056232
136pentose-phosphate shunt (GO:0006098)2.43701966
137gland morphogenesis (GO:0022612)2.40598773
138negative regulation of epidermis development (GO:0045683)2.39787145
139nuclear envelope organization (GO:0006998)2.37818621
140regulation of meiotic cell cycle (GO:0051445)2.37732734
141sphingoid metabolic process (GO:0046519)2.36508672
142maternal placenta development (GO:0001893)2.35906813
1433-UTR-mediated mRNA stabilization (GO:0070935)2.35639167
144positive regulation of protein export from nucleus (GO:0046827)2.34150235
145response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.34126482
146response to host (GO:0075136)2.34126482
147response to host defenses (GO:0052200)2.34126482
148cortical cytoskeleton organization (GO:0030865)2.32961981
149epithelial cell differentiation involved in prostate gland development (GO:0060742)2.31518960
150detection of molecule of bacterial origin (GO:0032490)2.29573386
151keratinization (GO:0031424)2.28875496
152positive regulation of adherens junction organization (GO:1903393)2.27433702
153negative regulation of DNA repair (GO:0045738)2.26245106
154peptidyl-threonine modification (GO:0018210)2.25352159
155nucleobase-containing small molecule interconversion (GO:0015949)2.23658476
156planar cell polarity pathway involved in neural tube closure (GO:0090179)2.23245643
157positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.22284064
158regulation of superoxide anion generation (GO:0032928)2.22205921
159protein targeting to plasma membrane (GO:0072661)2.21103209
160heterochromatin organization (GO:0070828)2.20968136
161regulation of glucose import in response to insulin stimulus (GO:2001273)2.20635315
162hippo signaling (GO:0035329)2.20618141
163cellular protein complex localization (GO:0034629)2.19352943
164negative regulation of necrotic cell death (GO:0060547)2.18861486
165regulation of necrotic cell death (GO:0010939)2.18588773
166positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.18336309
167regulation of translational fidelity (GO:0006450)2.18016798
168cellular response to osmotic stress (GO:0071470)2.17655502
169ribosomal large subunit biogenesis (GO:0042273)2.16765512
170protein complex localization (GO:0031503)2.16409256
171negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.16254326
172negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.16248941
173ribonucleoprotein complex biogenesis (GO:0022613)2.15971746
174regulation of leukocyte degranulation (GO:0043300)2.15591727
175modulation by symbiont of host cellular process (GO:0044068)2.14692356
176protoporphyrinogen IX metabolic process (GO:0046501)2.14190536
177peptidyl-threonine phosphorylation (GO:0018107)2.12140775
178response to peptidoglycan (GO:0032494)2.12046866
179mRNA transcription (GO:0009299)2.11644581

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.90846699
2E2F7_22180533_ChIP-Seq_HELA_Human5.39854347
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.10255461
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.68534447
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.18566714
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.16440054
7AR_21909140_ChIP-Seq_LNCAP_Human2.80672524
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72892509
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.67070873
10ZNF263_19887448_ChIP-Seq_K562_Human2.23963802
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21615479
12MYC_22102868_ChIP-Seq_BL_Human2.17768454
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.15368204
14KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.00850308
15ATF3_27146783_Chip-Seq_COLON_Human1.92050064
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.91085997
17ESR1_21235772_ChIP-Seq_MCF-7_Human1.90211313
18VDR_21846776_ChIP-Seq_THP-1_Human1.87353166
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.85602671
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.84339608
21CLOCK_20551151_ChIP-Seq_293T_Human1.80489784
22* TCF7_22412390_ChIP-Seq_EML_Mouse1.73813991
23* FOXO3_23340844_ChIP-Seq_DLD1_Human1.73330844
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.72521426
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72476997
26* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.70973190
27ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.68051556
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.67096124
29GATA6_25053715_ChIP-Seq_YYC3_Human1.59651143
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.55648924
31RACK7_27058665_Chip-Seq_MCF-7_Human1.55160979
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52610352
33FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.52592858
34SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50455394
35KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49757758
36LXR_22292898_ChIP-Seq_THP-1_Human1.49216184
37SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.48120267
38SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.48120267
39ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.47469850
40* RUNX1_27514584_Chip-Seq_MCF-7_Human1.47040915
41* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45052107
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39284107
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38830934
44* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38147869
45* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37830416
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37545032
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35548491
48KDM2B_26808549_Chip-Seq_DND41_Human1.35165237
49CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30811728
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30664940
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29977981
52* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29926818
53* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29488997
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.29160348
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28988703
56UTX_26944678_Chip-Seq_JUKART_Human1.28745541
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.28146294
58P63_26484246_Chip-Seq_KERATINOCYTES_Human1.27235581
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25414849
60NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24974497
61CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23337013
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23173401
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.22671685
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.22310762
65CHD1_26751641_Chip-Seq_LNCaP_Human1.21395752
66SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20547448
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19873536
68MAF_26560356_Chip-Seq_TH1_Human1.19739698
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19385081
70TCF3_18692474_ChIP-Seq_MEFs_Mouse1.19107133
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.18402943
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17677816
73SPI1_23127762_ChIP-Seq_K562_Human1.17401239
74UBF1/2_26484160_Chip-Seq_HMECs_Human1.17289425
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16747316
76VDR_24763502_ChIP-Seq_THP-1_Human1.15868707
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15653434
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13118998
79* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.12775806
80GATA1_19941826_ChIP-Seq_K562_Human1.11815292
81* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11695037
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.11390290
83KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.11390290
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.11390290
85SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10991895
86* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10979098
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10760138
88BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10539816
89* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09104525
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.08561212
91NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07986070
92PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07798575
93GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.07510436
94HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05608556
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04969859
96TBX20_22080862_ChIP-Seq_HEART_Mouse1.04756360
97TBX20_22328084_ChIP-Seq_HEART_Mouse1.04756360
98SCL_19346495_ChIP-Seq_HPC-7_Human1.04571472
99SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04385698
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04380463
101NANOG_21062744_ChIP-ChIP_HESCs_Human1.03732410
102* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03575520
103* KLF5_25053715_ChIP-Seq_YYC3_Human1.02944014
104SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02525516
105ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02329609
106GATA3_24758297_ChIP-Seq_MCF-7_Human1.01733901
107EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00973402
108* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00501682
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00185100
110NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99458936
111MYC_18555785_ChIP-Seq_MESCs_Mouse0.99357113
112* NCOR1_26117541_ChIP-Seq_K562_Human0.98677927
113* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98132723
114BP1_19119308_ChIP-ChIP_Hs578T_Human0.98078905
115GATA1_19941827_ChIP-Seq_MEL_Mouse0.97233794
116* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96822414
117GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96653603
118CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96606086
119KDM2B_26808549_Chip-Seq_K562_Human0.95993825
120GATA2_21666600_ChIP-Seq_HMVEC_Human0.95755134
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95699631
122MYB_26560356_Chip-Seq_TH2_Human0.95126658
123MYC_18358816_ChIP-ChIP_MESCs_Mouse0.95026668
124UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94730655
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94652847
126TP53_22127205_ChIP-Seq_IMR90_Human0.94099900
127GATA4_25053715_ChIP-Seq_YYC3_Human0.93850246
128FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.93686820
129TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93171029
130MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92994659
131SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92993280
132FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92514933
133PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.91917341
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90431170
135SOX2_20726797_ChIP-Seq_SW620_Human0.85380977
136CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84507815
137* STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84183285
138ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83320058
139TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.82655804
140NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82636120
141TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82435386

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.08946083
2MP0002796_impaired_skin_barrier3.25795422
3MP0009379_abnormal_foot_pigmentation3.05129355
4MP0003693_abnormal_embryo_hatching3.02230187
5MP0002877_abnormal_melanocyte_morpholog2.80531342
6MP0003453_abnormal_keratinocyte_physiol2.68591748
7MP0003705_abnormal_hypodermis_morpholog2.66186694
8MP0003566_abnormal_cell_adhesion2.57301039
9MP0010352_gastrointestinal_tract_polyps2.52427263
10MP0003191_abnormal_cellular_cholesterol2.34231832
11MP0003718_maternal_effect2.30324682
12MP0008260_abnormal_autophagy2.28069564
13MP0004957_abnormal_blastocyst_morpholog2.16613998
14MP0005076_abnormal_cell_differentiation2.07011089
15MP0005409_darkened_coat_color2.05300755
16MP0004185_abnormal_adipocyte_glucose2.04225336
17MP0000579_abnormal_nail_morphology2.03999003
18MP0002060_abnormal_skin_morphology2.02719659
19MP0010678_abnormal_skin_adnexa2.01794963
20MP0005501_abnormal_skin_physiology2.01141470
21MP0005451_abnormal_body_composition2.00801115
22MP0008438_abnormal_cutaneous_collagen1.99063658
23MP0001216_abnormal_epidermal_layer1.92269084
24MP0003111_abnormal_nucleus_morphology1.89047268
25MP0003941_abnormal_skin_development1.87837431
26MP0004264_abnormal_extraembryonic_tissu1.85144598
27MP0010094_abnormal_chromosome_stability1.83709246
28MP0003300_gastrointestinal_ulcer1.81581914
29MP0000383_abnormal_hair_follicle1.79895898
30MP0004233_abnormal_muscle_weight1.79294781
31MP0003077_abnormal_cell_cycle1.78700780
32MP0000490_abnormal_crypts_of1.71447044
33MP0001849_ear_inflammation1.68553942
34MP0005275_abnormal_skin_tensile1.66382044
35MP0002009_preneoplasia1.60816750
36MP0005023_abnormal_wound_healing1.60350158
37MP0003950_abnormal_plasma_membrane1.55958685
38MP0005666_abnormal_adipose_tissue1.50507768
39MP0000377_abnormal_hair_follicle1.50131818
40MP0002098_abnormal_vibrissa_morphology1.46321077
41MP0001346_abnormal_lacrimal_gland1.39168285
42MP0002254_reproductive_system_inflammat1.38397277
43MP0000350_abnormal_cell_proliferation1.38390191
44MP0001851_eye_inflammation1.37482220
45MP0004272_abnormal_basement_membrane1.34456151
46MP0001958_emphysema1.33516968
47MP0002653_abnormal_ependyma_morphology1.31274518
48MP0005310_abnormal_salivary_gland1.29091261
49MP0010771_integument_phenotype1.28709808
50MP0002396_abnormal_hematopoietic_system1.25511647
51MP0004947_skin_inflammation1.24910451
52MP0001545_abnormal_hematopoietic_system1.23995373
53MP0005397_hematopoietic_system_phenotyp1.23995373
54MP0003763_abnormal_thymus_physiology1.23522691
55MP0002006_tumorigenesis1.23096552
56MP0000465_gastrointestinal_hemorrhage1.22359228
57MP0005464_abnormal_platelet_physiology1.20297591
58MP0006138_congestive_heart_failure1.17724862
59MP0005375_adipose_tissue_phenotype1.17211275
60MP0003699_abnormal_female_reproductive1.16603349
61MP0000467_abnormal_esophagus_morphology1.15243468
62MP0001730_embryonic_growth_arrest1.15081512
63MP0005257_abnormal_intraocular_pressure1.14266536
64MP0008057_abnormal_DNA_replication1.13450156
65MP0010630_abnormal_cardiac_muscle1.12115162
66MP0003303_peritoneal_inflammation1.11735395
67MP0002166_altered_tumor_susceptibility1.10301889
68MP0004858_abnormal_nervous_system1.09071489
69MP0000627_abnormal_mammary_gland1.08614279
70MP0000427_abnormal_hair_cycle1.08100217
71MP0002085_abnormal_embryonic_tissue1.07984402
72MP0002019_abnormal_tumor_incidence1.07039052
73MP0002084_abnormal_developmental_patter1.06465793
74MP0005395_other_phenotype1.06449191
75MP0006054_spinal_hemorrhage1.03766333
76MP0002086_abnormal_extraembryonic_tissu1.02885104
77MP0009278_abnormal_bone_marrow1.02578931
78MP0001119_abnormal_female_reproductive1.02505139
79MP0010307_abnormal_tumor_latency1.00923498
80MP0003123_paternal_imprinting1.00760637
81MP0009931_abnormal_skin_appearance1.00693433
82MP0001915_intracranial_hemorrhage1.00504159
83MP0004782_abnormal_surfactant_physiolog0.99884283
84MP0010155_abnormal_intestine_physiology0.99771814
85MP0008007_abnormal_cellular_replicative0.97864136
86MP0004808_abnormal_hematopoietic_stem0.97780956
87MP0001697_abnormal_embryo_size0.97745634
88MP0000015_abnormal_ear_pigmentation0.96555869
89MP0009672_abnormal_birth_weight0.92362230
90MP0003279_aneurysm0.90957255
91MP0008877_abnormal_DNA_methylation0.90864323
92MP0004087_abnormal_muscle_fiber0.90276455
93MP0005380_embryogenesis_phenotype0.89076217
94MP0001672_abnormal_embryogenesis/_devel0.89076217
95MP0004381_abnormal_hair_follicle0.88979861
96MP0003937_abnormal_limbs/digits/tail_de0.88629947
97MP0000613_abnormal_salivary_gland0.88551085
98MP0005384_cellular_phenotype0.88339818
99MP0000462_abnormal_digestive_system0.87229837
100MP0001881_abnormal_mammary_gland0.86981308
101MP0000477_abnormal_intestine_morphology0.86445075
102MP0003787_abnormal_imprinting0.86092969
103MP0005408_hypopigmentation0.85617820
104MP0000762_abnormal_tongue_morphology0.85005938
105MP0008932_abnormal_embryonic_tissue0.84802204
106MP0002269_muscular_atrophy0.83913134
107MP0000858_altered_metastatic_potential0.83879937
108MP0003828_pulmonary_edema0.82236397
109MP0003221_abnormal_cardiomyocyte_apopto0.81839749
110MP0010030_abnormal_orbit_morphology0.81625582
111MP0000428_abnormal_craniofacial_morphol0.79426506
112MP0000759_abnormal_skeletal_muscle0.79269209
113MP0005621_abnormal_cell_physiology0.79244176
114MP0003091_abnormal_cell_migration0.79212485
115MP0003315_abnormal_perineum_morphology0.78587591
116MP0000747_muscle_weakness0.78509545
117MP0000003_abnormal_adipose_tissue0.77462197
118MP0000733_abnormal_muscle_development0.77398858
119MP0000653_abnormal_sex_gland0.74849239
120MP0005058_abnormal_lysosome_morphology0.74491629
121MP0009780_abnormal_chondrocyte_physiolo0.74365820
122MP0002405_respiratory_system_inflammati0.73774360
123MP0003656_abnormal_erythrocyte_physiolo0.73443303
124MP0000767_abnormal_smooth_muscle0.72952696
125MP0003436_decreased_susceptibility_to0.72696137
126MP0002998_abnormal_bone_remodeling0.71426398
127MP0002088_abnormal_embryonic_growth/wei0.71208592
128MP0004084_abnormal_cardiac_muscle0.71112109
129MP0003448_altered_tumor_morphology0.71048532
130MP0000313_abnormal_cell_death0.70925810
131MP0002080_prenatal_lethality0.70918270
132MP0003984_embryonic_growth_retardation0.70528789
133MP0000470_abnormal_stomach_morphology0.69931430
134MP0004130_abnormal_muscle_cell0.69088509
135MP0000751_myopathy0.68845047
136MP0000685_abnormal_immune_system0.68812425
137MP0001784_abnormal_fluid_regulation0.68447219
138MP0000358_abnormal_cell_content/0.66608633
139MP0000537_abnormal_urethra_morphology0.65624929

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)4.75784132
2Male infertility (HP:0003251)4.74810493
3Milia (HP:0001056)4.41976497
4Increased connective tissue (HP:0009025)3.61720989
5Right ventricular cardiomyopathy (HP:0011663)3.41825215
6Protrusio acetabuli (HP:0003179)3.40302635
7Abnormal hemoglobin (HP:0011902)3.37937114
8Fragile nails (HP:0001808)3.23741506
9Pili torti (HP:0003777)3.07952736
10Atrophic scars (HP:0001075)2.93591215
11Plantar hyperkeratosis (HP:0007556)2.92274883
12Onycholysis (HP:0001806)2.87868427
13Ankyloglossia (HP:0010296)2.80727999
14Premature rupture of membranes (HP:0001788)2.79954340
15Abnormality of the fingertips (HP:0001211)2.78332231
16Osteolytic defects of the hand bones (HP:0009699)2.77677102
17Osteolytic defects of the phalanges of the hand (HP:0009771)2.77677102
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.75205617
19Woolly hair (HP:0002224)2.69498174
20Blepharitis (HP:0000498)2.65176360
21Abnormality of skeletal muscle fiber size (HP:0012084)2.63924826
22Distal lower limb muscle weakness (HP:0009053)2.63579792
23Distal lower limb amyotrophy (HP:0008944)2.56389385
24Premature ovarian failure (HP:0008209)2.53671786
25Increased IgE level (HP:0003212)2.53325126
26Sparse scalp hair (HP:0002209)2.51755349
27Centrally nucleated skeletal muscle fibers (HP:0003687)2.51358154
28Increased variability in muscle fiber diameter (HP:0003557)2.48788709
29Sandal gap (HP:0001852)2.43210010
30Shawl scrotum (HP:0000049)2.40955393
31Breast hypoplasia (HP:0003187)2.40924084
32Hyperacusis (HP:0010780)2.33256725
33Cerebral aneurysm (HP:0004944)2.31296408
34Hypotrichosis (HP:0001006)2.31089173
35Flat acetabular roof (HP:0003180)2.30265298
36Polycythemia (HP:0001901)2.30074232
37Nail dystrophy (HP:0008404)2.30058312
38Abnormality of cells of the erythroid lineage (HP:0012130)2.28480243
39Ankle contracture (HP:0006466)2.27735396
40Vertebral arch anomaly (HP:0008438)2.25549320
41Achilles tendon contracture (HP:0001771)2.25460787
42Disproportionate tall stature (HP:0001519)2.25434810
43Biliary tract neoplasm (HP:0100574)2.23809411
44Abnormal blistering of the skin (HP:0008066)2.23273139
45Palmoplantar hyperkeratosis (HP:0000972)2.22548800
46Stenosis of the external auditory canal (HP:0000402)2.21313366
47Selective tooth agenesis (HP:0001592)2.19274964
48Rectal prolapse (HP:0002035)2.18550503
49Ulnar bowing (HP:0003031)2.16037943
50Abnormality of the gastric mucosa (HP:0004295)2.15896272
51Abnormality of oral frenula (HP:0000190)2.15446932
52Hyporeflexia of lower limbs (HP:0002600)2.09376331
53Aplasia/Hypoplasia of the patella (HP:0006498)2.09059402
54Aortic aneurysm (HP:0004942)2.08481682
55Curly hair (HP:0002212)2.08466771
56Spinal rigidity (HP:0003306)2.08102528
57Ventricular tachycardia (HP:0004756)2.06472582
58Palmar hyperkeratosis (HP:0010765)2.05126729
59Pustule (HP:0200039)2.04668020
60Cellulitis (HP:0100658)2.03043506
61Dysmetric saccades (HP:0000641)2.01616775
62Trismus (HP:0000211)2.01054630
63Short nail (HP:0001799)2.00145196
64Metaphyseal cupping (HP:0003021)2.00111984
65Abnormal number of erythroid precursors (HP:0012131)1.99919919
66Facial hemangioma (HP:0000329)1.99322687
67Arterial tortuosity (HP:0005116)1.98449364
68Acute myeloid leukemia (HP:0004808)1.97971346
69Fragile skin (HP:0001030)1.96395864
70Vertebral compression fractures (HP:0002953)1.95954253
71Abnormal hair laboratory examination (HP:0003328)1.95613897
72Patellar aplasia (HP:0006443)1.95465940
73Abnormality of nail color (HP:0100643)1.95256438
74Shallow orbits (HP:0000586)1.93614787
75Spinal cord lesions (HP:0100561)1.93011538
76Syringomyelia (HP:0003396)1.93011538
77Sparse lateral eyebrow (HP:0005338)1.92401848
78Obstructive sleep apnea (HP:0002870)1.91702067
79Dilatation of the ascending aorta (HP:0005111)1.89430643
80Reticulocytopenia (HP:0001896)1.89213432
81Foot dorsiflexor weakness (HP:0009027)1.89051134
82Thick nail (HP:0001805)1.88869995
83Abnormality of the Achilles tendon (HP:0005109)1.88543507
84Malignant gastrointestinal tract tumors (HP:0006749)1.88234035
85Gastrointestinal carcinoma (HP:0002672)1.88234035
86Papillary thyroid carcinoma (HP:0002895)1.87726266
87Insomnia (HP:0100785)1.87704289
88Thin bony cortex (HP:0002753)1.86297183
89Polygenic inheritance (HP:0010982)1.84335810
90Ectropion (HP:0000656)1.82926517
91Lower limb amyotrophy (HP:0007210)1.81887377
92Vascular tortuosity (HP:0004948)1.81486842
93Interstitial pulmonary disease (HP:0006530)1.81196546
94Genu recurvatum (HP:0002816)1.80665220
95Segmental peripheral demyelination/remyelination (HP:0003481)1.79896057
96Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.79345480
97Short 1st metacarpal (HP:0010034)1.79345480
98Abnormality of lateral ventricle (HP:0030047)1.79337847
99Rib fusion (HP:0000902)1.79046023
100Patellar dislocation (HP:0002999)1.78877373
101Subacute progressive viral hepatitis (HP:0006572)1.78787141
102Villous atrophy (HP:0011473)1.78086823
103Abnormality of small intestinal villus morphology (HP:0011472)1.78086823
104Spinal cord compression (HP:0002176)1.77575362
105Chin dimple (HP:0010751)1.77443653
106Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.76887388
107Eczematoid dermatitis (HP:0000976)1.76286829
108Difficulty climbing stairs (HP:0003551)1.75816650
109Neonatal death (HP:0003811)1.75742561
110Abnormality of the distal phalanx of the thumb (HP:0009617)1.75651629
111Cortical dysplasia (HP:0002539)1.73799295
112Decreased motor nerve conduction velocity (HP:0003431)1.72539924
113Insulin-resistant diabetes mellitus (HP:0000831)1.72468287
114Hematochezia (HP:0002573)1.72138982
115Mitral regurgitation (HP:0001653)1.72082309
116Aortic dissection (HP:0002647)1.71395830
117Flared metaphyses (HP:0003015)1.70975050
118Alopecia of scalp (HP:0002293)1.69267709
119Abnormal vertebral ossification (HP:0100569)1.68868180
120Thrombocytosis (HP:0001894)1.68273768
121Slow saccadic eye movements (HP:0000514)1.67253943
122Abnormality of the 1st metacarpal (HP:0010009)1.66633826
123Volvulus (HP:0002580)1.66599511
124Secondary amenorrhea (HP:0000869)1.65707055
125Abnormality of the tricuspid valve (HP:0001702)1.65637183
126Resting tremor (HP:0002322)1.63953252
127Peritonitis (HP:0002586)1.63870631
128Hypoplastic labia majora (HP:0000059)1.63469825
129Elbow flexion contracture (HP:0002987)1.63047866
130Aneurysm (HP:0002617)1.62679711
131Abnormality of the distal phalanges of the toes (HP:0010182)1.61882801
132Gingivitis (HP:0000230)1.61798892
133Advanced eruption of teeth (HP:0006288)1.61732747
134Upper limb amyotrophy (HP:0009129)1.61185281
135Distal upper limb amyotrophy (HP:0007149)1.61185281
136Type 1 muscle fiber predominance (HP:0003803)1.60229307
137Chronic bronchitis (HP:0004469)1.60170476
138Basal cell carcinoma (HP:0002671)1.59702860
139Abnormality of the acetabulum (HP:0003170)1.59247068
140Spondylolisthesis (HP:0003302)1.59241275
141Oligodontia (HP:0000677)1.58678359
142Increased mean platelet volume (HP:0011877)1.58664740
143Craniofacial hyperostosis (HP:0004493)1.58291887
144Acanthosis nigricans (HP:0000956)1.58290030
145Wormian bones (HP:0002645)1.57993220
146Congenital ichthyosiform erythroderma (HP:0007431)1.57976006
147Chromsome breakage (HP:0040012)1.57631563
148Broad face (HP:0000283)1.57099233
149Abnormality of the salivary glands (HP:0010286)1.56741656
150Abnormality of the labia majora (HP:0012881)1.56455317
151Abnormality of the foot musculature (HP:0001436)1.56205695
152Recurrent abscess formation (HP:0002722)1.55501800
153Abnormal ossification of hand bones (HP:0005921)1.55212868
154Bladder diverticulum (HP:0000015)1.55090529
155Spontaneous hematomas (HP:0007420)1.54736909
156Cervical subluxation (HP:0003308)1.54680109
157Poikiloderma (HP:0001029)1.54652600
158Mitral valve prolapse (HP:0001634)1.54335640
159Bowel incontinence (HP:0002607)1.53453610
160Carpal bone hypoplasia (HP:0001498)1.52973136
161Oral leukoplakia (HP:0002745)1.52888946
162Down-sloping shoulders (HP:0200021)1.52294608
163Mildly elevated creatine phosphokinase (HP:0008180)1.51802592
164Aplasia cutis congenita (HP:0001057)1.51481678
165Viral hepatitis (HP:0006562)1.50929826
166Abnormality of the labia minora (HP:0012880)1.49730440
167Birth length less than 3rd percentile (HP:0003561)1.49211104
168Abnormal platelet volume (HP:0011876)1.47920141
169Laryngomalacia (HP:0001601)1.47724299
170Squamous cell carcinoma (HP:0002860)1.47360762
171Micronodular cirrhosis (HP:0001413)1.47207003
172Deep palmar crease (HP:0006191)1.47062174

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.85592535
2LATS13.57558861
3TAOK32.93858520
4MAPKAPK32.87429283
5MAP3K62.74579950
6TRIB32.64420903
7SMG12.60627306
8PRPF4B2.53531620
9LATS22.40683599
10STK102.30647636
11CDC72.27521948
12MOS2.25411033
13TAOK12.23936205
14KSR22.18886892
15RPS6KB22.16643637
16DMPK2.13878203
17NEK22.04122435
18RIPK41.93928587
19ICK1.93393303
20TTK1.91376015
21BMPR21.87948874
22LRRK21.83760057
23TRPM71.77522055
24STK38L1.77331233
25PKN21.69452309
26IRAK31.67742289
27SIK11.65944871
28RIPK11.57670060
29CDK121.57029877
30EIF2AK11.42317265
31MAP3K81.41528661
32STK31.39413919
33MAP3K21.35216896
34PLK41.34685308
35RAF11.27929274
36MAP2K21.22841478
37HIPK21.21664137
38CDK91.20137889
39MST1R1.18216001
40ARAF1.18068334
41MST41.17894476
42FRK1.10773853
43MAP3K91.08560105
44ERBB41.07096709
45IRAK41.06886602
46MAP3K31.04888098
47MAP3K131.04156245
48PBK1.03845982
49WNK11.01884474
50MELK1.01509170
51CDK60.98530596
52AURKB0.97948674
53CSK0.95425274
54NTRK10.95161047
55MAP3K120.94002622
56IRAK20.91547857
57MAP3K10.91508382
58RET0.90951573
59MAP3K100.88963074
60TAOK20.88372097
61EPHA20.88211217
62BRAF0.86384297
63MAPKAPK50.86131711
64PLK10.85949306
65SGK30.84414066
66MYLK0.83609477
67FER0.82791174
68NLK0.82317921
69PRKD20.82111806
70ERN10.80409618
71FGFR40.80208788
72CDC42BPA0.77561373
73JAK30.77261901
74PAK20.74946463
75EPHB10.74507207
76PTK60.74366885
77ZAP700.72838055
78TYRO30.72802801
79RPS6KA40.72413043
80PAK40.72239119
81KSR10.72183996
82NUAK10.72131325
83CHEK20.70183948
84MATK0.69485418
85MAP2K30.69410509
86PDPK10.68734815
87CDK70.67673348
88STK240.66827948
89MAP3K110.65377544
90ILK0.65078988
91ALK0.65034701
92AURKA0.63684136
93CDK40.62801977
94RPS6KA20.61786157
95NEK90.60532111
96JAK20.59334216
97PDGFRA0.57536482
98EPHA30.56922196
99STK380.56490866
100MAPK150.53940224
101MARK20.52242497
102STK40.51494872
103PIK3CG0.50849381
104PIM10.50691534
105ROCK20.50591603
106BMX0.49275816
107MAP2K10.49240469
108PTK20.49139195
109TTN0.48054037
110RPS6KC10.48044412
111RPS6KL10.48044412
112MAPKAPK20.47919504
113PDGFRB0.47728099
114CLK10.46776130
115MTOR0.46471079
116PRKG20.45835946
117MAP4K10.44639810
118SCYL20.44341137
119FES0.44110402
120TESK10.43613455
121GRK60.43233507
122PAK10.42786644
123ATM0.40775685
124NME20.40418175
125RPS6KA10.39371585
126MAPK120.39356414
127ABL10.39020697
128FGFR30.38567150
129TYK20.37899248
130MET0.37012128
131PRKCI0.34460372
132CHEK10.33503571
133PRKD10.32681859
134TEC0.32188594
135NEK10.31294951
136FGR0.29952727
137DDR20.29902211

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.38814738
2Cell cycle_Homo sapiens_hsa041102.14140324
3Thyroid cancer_Homo sapiens_hsa052161.78846308
4p53 signaling pathway_Homo sapiens_hsa041151.69542095
5Chronic myeloid leukemia_Homo sapiens_hsa052201.62934455
6Small cell lung cancer_Homo sapiens_hsa052221.61371430
7VEGF signaling pathway_Homo sapiens_hsa043701.59336058
8Adherens junction_Homo sapiens_hsa045201.58771932
9MicroRNAs in cancer_Homo sapiens_hsa052061.57143305
10* Pancreatic cancer_Homo sapiens_hsa052121.55610014
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.51509700
12Ribosome_Homo sapiens_hsa030101.51435543
13RNA degradation_Homo sapiens_hsa030181.49555648
14Dorso-ventral axis formation_Homo sapiens_hsa043201.48544114
15TGF-beta signaling pathway_Homo sapiens_hsa043501.47909677
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.46971929
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.46536464
18Central carbon metabolism in cancer_Homo sapiens_hsa052301.46091042
19Prolactin signaling pathway_Homo sapiens_hsa049171.45633468
20Bladder cancer_Homo sapiens_hsa052191.45044413
21Basal transcription factors_Homo sapiens_hsa030221.35349779
22Ovarian steroidogenesis_Homo sapiens_hsa049131.33883917
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33276158
24Oocyte meiosis_Homo sapiens_hsa041141.29369996
25Endometrial cancer_Homo sapiens_hsa052131.28327869
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25965649
27Platelet activation_Homo sapiens_hsa046111.25344980
28DNA replication_Homo sapiens_hsa030301.25299079
29Non-small cell lung cancer_Homo sapiens_hsa052231.23076469
30Hippo signaling pathway_Homo sapiens_hsa043901.20761204
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19757793
32Insulin signaling pathway_Homo sapiens_hsa049101.19729928
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19551939
34Toxoplasmosis_Homo sapiens_hsa051451.19420590
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.15924172
36Homologous recombination_Homo sapiens_hsa034401.15670815
37Renal cell carcinoma_Homo sapiens_hsa052111.15158993
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14289093
39ECM-receptor interaction_Homo sapiens_hsa045121.13407617
40Colorectal cancer_Homo sapiens_hsa052101.13254826
41Other glycan degradation_Homo sapiens_hsa005111.12667694
42Mismatch repair_Homo sapiens_hsa034301.12456199
43Acute myeloid leukemia_Homo sapiens_hsa052211.12317467
44GnRH signaling pathway_Homo sapiens_hsa049121.12316829
45Base excision repair_Homo sapiens_hsa034101.11771450
46Prostate cancer_Homo sapiens_hsa052151.11009142
47Notch signaling pathway_Homo sapiens_hsa043301.08588943
48Tight junction_Homo sapiens_hsa045301.07623063
49RNA transport_Homo sapiens_hsa030131.06822893
50Proteoglycans in cancer_Homo sapiens_hsa052051.05481462
51Focal adhesion_Homo sapiens_hsa045101.03504727
52Long-term potentiation_Homo sapiens_hsa047201.00492091
53Shigellosis_Homo sapiens_hsa051311.00409551
54Amoebiasis_Homo sapiens_hsa051461.00069668
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99489141
56HIF-1 signaling pathway_Homo sapiens_hsa040660.99316735
57HTLV-I infection_Homo sapiens_hsa051660.97819883
58Non-homologous end-joining_Homo sapiens_hsa034500.96579574
59Estrogen signaling pathway_Homo sapiens_hsa049150.96294497
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95582354
61mRNA surveillance pathway_Homo sapiens_hsa030150.95135644
62Apoptosis_Homo sapiens_hsa042100.94409039
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93961558
64FoxO signaling pathway_Homo sapiens_hsa040680.92480028
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92460043
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90332903
67Hepatitis B_Homo sapiens_hsa051610.90307314
68B cell receptor signaling pathway_Homo sapiens_hsa046620.89042525
69mTOR signaling pathway_Homo sapiens_hsa041500.89026953
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87679283
71Circadian rhythm_Homo sapiens_hsa047100.87161254
72Glioma_Homo sapiens_hsa052140.87006785
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86928674
74Choline metabolism in cancer_Homo sapiens_hsa052310.86795749
75Pentose phosphate pathway_Homo sapiens_hsa000300.85924275
76Leishmaniasis_Homo sapiens_hsa051400.85024355
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84683030
78Linoleic acid metabolism_Homo sapiens_hsa005910.83686771
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.83325985
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.83145476
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82994696
82Viral carcinogenesis_Homo sapiens_hsa052030.82574421
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81512266
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81119118
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79691121
86Osteoclast differentiation_Homo sapiens_hsa043800.79472841
87TNF signaling pathway_Homo sapiens_hsa046680.78574415
88* Pathways in cancer_Homo sapiens_hsa052000.76647231
89AMPK signaling pathway_Homo sapiens_hsa041520.75009433
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74048849
91Herpes simplex infection_Homo sapiens_hsa051680.71521175
92Malaria_Homo sapiens_hsa051440.69695423
93Melanoma_Homo sapiens_hsa052180.69431204
94Fanconi anemia pathway_Homo sapiens_hsa034600.69172206
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.69000881
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67609336
97Measles_Homo sapiens_hsa051620.67568296
98Nucleotide excision repair_Homo sapiens_hsa034200.67522589
99Influenza A_Homo sapiens_hsa051640.66646631
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65609457
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63267390
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.62153721
103Galactose metabolism_Homo sapiens_hsa000520.61768346
104Rap1 signaling pathway_Homo sapiens_hsa040150.61247901
105Prion diseases_Homo sapiens_hsa050200.60840751
106Tuberculosis_Homo sapiens_hsa051520.59815611
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.59801468
108Endocytosis_Homo sapiens_hsa041440.59629316
109Insulin resistance_Homo sapiens_hsa049310.57842950
110Wnt signaling pathway_Homo sapiens_hsa043100.57437534
111Melanogenesis_Homo sapiens_hsa049160.56985398
112Dilated cardiomyopathy_Homo sapiens_hsa054140.56854239
113Hematopoietic cell lineage_Homo sapiens_hsa046400.56674977
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56216677
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.56211882
116Salmonella infection_Homo sapiens_hsa051320.55963788
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55667200
118Antigen processing and presentation_Homo sapiens_hsa046120.55581622
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55427112
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54735751
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53408272
122Chemokine signaling pathway_Homo sapiens_hsa040620.53407055
123Gap junction_Homo sapiens_hsa045400.52939102
124Inositol phosphate metabolism_Homo sapiens_hsa005620.52446925
125T cell receptor signaling pathway_Homo sapiens_hsa046600.52077186
126Hepatitis C_Homo sapiens_hsa051600.51965374
127Epstein-Barr virus infection_Homo sapiens_hsa051690.51937652
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51677331
129ErbB signaling pathway_Homo sapiens_hsa040120.50369833

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