RALGAPA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sequestering of triglyceride (GO:0010889)5.13216398
2fatty acid transmembrane transport (GO:1902001)4.80352643
3phospholipid homeostasis (GO:0055091)4.79538395
4carnitine shuttle (GO:0006853)4.78822972
5valine metabolic process (GO:0006573)4.24277937
6low-density lipoprotein particle clearance (GO:0034383)4.13954519
7regulation of protein activation cascade (GO:2000257)4.10289715
8regulation of complement activation (GO:0030449)4.08015204
9negative regulation of protein activation cascade (GO:2000258)3.96428141
10positive regulation of fatty acid beta-oxidation (GO:0032000)3.82891043
11negative regulation of humoral immune response (GO:0002921)3.80614286
12negative regulation of complement activation (GO:0045916)3.78510828
13cilium or flagellum-dependent cell motility (GO:0001539)3.77671183
14carnitine transmembrane transport (GO:1902603)3.75574730
15macroautophagy (GO:0016236)3.65419931
16fatty acid beta-oxidation (GO:0006635)3.62164855
17regulation of cholesterol storage (GO:0010885)3.57698534
18positive regulation of fatty acid oxidation (GO:0046321)3.53819205
19biotin metabolic process (GO:0006768)3.52012045
20amino-acid betaine transport (GO:0015838)3.50832335
21carnitine transport (GO:0015879)3.50832335
22histone H3-K36 demethylation (GO:0070544)3.47852418
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.47402124
24interkinetic nuclear migration (GO:0022027)3.46983708
25negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.45499334
26detection of molecule of bacterial origin (GO:0032490)3.44577607
27urea cycle (GO:0000050)3.36810668
28urea metabolic process (GO:0019627)3.36810668
29plasma lipoprotein particle clearance (GO:0034381)3.31858105
30regulation of triglyceride catabolic process (GO:0010896)3.31146973
31alpha-linolenic acid metabolic process (GO:0036109)3.28343042
32positive regulation of gamma-delta T cell activation (GO:0046645)3.27343567
33cellular response to ethanol (GO:0071361)3.26159383
34fatty acid oxidation (GO:0019395)3.24165611
35drug catabolic process (GO:0042737)3.22248829
36ethanol oxidation (GO:0006069)3.20200664
37regulation of bile acid biosynthetic process (GO:0070857)3.18909083
38embryonic retina morphogenesis in camera-type eye (GO:0060059)3.17773163
39fatty acid catabolic process (GO:0009062)3.15322886
40exogenous drug catabolic process (GO:0042738)3.15165394
41lipid oxidation (GO:0034440)3.15135518
42positive regulation of cholesterol efflux (GO:0010875)3.14627524
43positive regulation of lipid catabolic process (GO:0050996)3.14316674
44triglyceride homeostasis (GO:0070328)3.12708847
45acylglycerol homeostasis (GO:0055090)3.12708847
46homocysteine metabolic process (GO:0050667)3.12649139
47triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.12038731
48intracellular lipid transport (GO:0032365)3.11214660
49negative regulation of lipase activity (GO:0060192)3.11158562
50negative regulation of B cell mediated immunity (GO:0002713)3.09486935
51negative regulation of immunoglobulin mediated immune response (GO:0002890)3.09486935
52negative regulation of lipid storage (GO:0010888)3.08488177
532-oxoglutarate metabolic process (GO:0006103)3.06459080
54positive regulation of lipid storage (GO:0010884)3.02791996
55positive regulation of cholesterol transport (GO:0032376)3.02266139
56positive regulation of sterol transport (GO:0032373)3.02266139
57nitrogen cycle metabolic process (GO:0071941)2.99394350
58regulation of fatty acid oxidation (GO:0046320)2.98933451
59bundle of His cell to Purkinje myocyte communication (GO:0086069)2.98407847
60regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.95859479
61skeletal muscle adaptation (GO:0043501)2.95811661
62lipoprotein transport (GO:0042953)2.95587073
63fatty acid homeostasis (GO:0055089)2.90631003
64regulation of humoral immune response (GO:0002920)2.89478264
65phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.89388882
66histone H3-K4 trimethylation (GO:0080182)2.88713209
67regulation of fatty acid beta-oxidation (GO:0031998)2.88306839
68maintenance of gastrointestinal epithelium (GO:0030277)2.87554633
69acetyl-CoA metabolic process (GO:0006084)2.86971864
70ethanol metabolic process (GO:0006067)2.85736249
71detection of external biotic stimulus (GO:0098581)2.83600406
72positive regulation of cellular amide metabolic process (GO:0034250)2.83310959
73dicarboxylic acid biosynthetic process (GO:0043650)2.82222283
74brown fat cell differentiation (GO:0050873)2.81374910
75complement activation, alternative pathway (GO:0006957)2.80940568
76branched-chain amino acid metabolic process (GO:0009081)2.79165585
77cellular extravasation (GO:0045123)2.79126704
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.79103997
79phospholipid efflux (GO:0033700)2.77936602
80regulation of gamma-delta T cell differentiation (GO:0045586)2.77649452
81epoxygenase P450 pathway (GO:0019373)2.77052597
82lysine metabolic process (GO:0006553)2.76672728
83lysine catabolic process (GO:0006554)2.76672728
84negative regulation of fibrinolysis (GO:0051918)2.75872540
85monocarboxylic acid catabolic process (GO:0072329)2.72710285
86regulation of macrophage derived foam cell differentiation (GO:0010743)2.72475010
87positive regulation of glycolytic process (GO:0045821)2.70782323
88positive regulation of p38MAPK cascade (GO:1900745)2.70579972
89regulation of lipid storage (GO:0010883)2.69854454
90branched-chain amino acid catabolic process (GO:0009083)2.67771426
91triglyceride catabolic process (GO:0019433)2.67159612
92axonemal dynein complex assembly (GO:0070286)2.65657157
93striated muscle atrophy (GO:0014891)2.65257241
94amino-acid betaine metabolic process (GO:0006577)2.62983113
95I-kappaB phosphorylation (GO:0007252)2.62895763
96carnitine metabolic process (GO:0009437)2.61727588
97erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.60611514
98L-phenylalanine catabolic process (GO:0006559)2.60611514
99regulation of gamma-delta T cell activation (GO:0046643)2.60141441
100quaternary ammonium group transport (GO:0015697)2.59052428
101regulation of apoptotic cell clearance (GO:2000425)2.58608055
102acylglycerol catabolic process (GO:0046464)2.58486693
103neutral lipid catabolic process (GO:0046461)2.58486693
104regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.57791834
105lipid homeostasis (GO:0055088)2.56878324
106plasma lipoprotein particle assembly (GO:0034377)2.56694150
107hormone catabolic process (GO:0042447)2.55042772
108iron ion import (GO:0097286)2.52715810
109diacylglycerol metabolic process (GO:0046339)2.49135740
110regulation of fibrinolysis (GO:0051917)2.48973140
111growth hormone receptor signaling pathway (GO:0060396)2.48935052
112insulin-like growth factor receptor signaling pathway (GO:0048009)2.48622893
113protein activation cascade (GO:0072376)2.47982039
114cardiac muscle hypertrophy (GO:0003300)2.47973128
115histone lysine demethylation (GO:0070076)2.47689270
116short-chain fatty acid metabolic process (GO:0046459)2.45970359
117muscle atrophy (GO:0014889)2.44895671
118detection of bacterium (GO:0016045)2.44430776
119detection of biotic stimulus (GO:0009595)2.44399179
120relaxation of cardiac muscle (GO:0055119)2.44082191
121histone H3-K9 demethylation (GO:0033169)2.43370622
122Golgi to endosome transport (GO:0006895)2.43294987
123aromatic amino acid family catabolic process (GO:0009074)2.41890700
124regulation of sterol transport (GO:0032371)2.41741044
125regulation of cholesterol transport (GO:0032374)2.41741044
126cholesterol efflux (GO:0033344)2.41479786
127complement activation, classical pathway (GO:0006958)2.41407635
128L-phenylalanine metabolic process (GO:0006558)2.41188904
129erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.41188904
130detection of other organism (GO:0098543)2.40314112
131nucleus localization (GO:0051647)2.40050643
132positive regulation of fatty acid metabolic process (GO:0045923)2.39045626
133cholesterol homeostasis (GO:0042632)2.38307616
134complement activation (GO:0006956)2.37533856
135acute-phase response (GO:0006953)2.36348139
136positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.36342322
137lipid storage (GO:0019915)2.34742395
138sterol homeostasis (GO:0055092)2.34257338
139regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.33177480
140regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.32295767
141lipoprotein metabolic process (GO:0042157)2.31789729
142very-low-density lipoprotein particle assembly (GO:0034379)2.31476793
143negative regulation of granulocyte differentiation (GO:0030853)2.31326840
144positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.31042253
145histone demethylation (GO:0016577)2.30139929
146epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.29858928
147high-density lipoprotein particle remodeling (GO:0034375)2.27065149
148production of molecular mediator involved in inflammatory response (GO:0002532)2.26609179
149hypotonic response (GO:0006971)2.26059773
150macrophage activation (GO:0042116)2.24945104
151regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.24200817
152epithelial structure maintenance (GO:0010669)2.24197735
153negative regulation of cholesterol transport (GO:0032375)2.23877884
154negative regulation of sterol transport (GO:0032372)2.23877884
155blood coagulation, intrinsic pathway (GO:0007597)2.21701048
156modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.21615975
157positive regulation by organism of defense response of other organism involved in symbiotic interact2.21615975
158modulation by symbiont of host immune response (GO:0052553)2.21615975
159positive regulation by symbiont of host defense response (GO:0052509)2.21615975
160modulation by symbiont of host defense response (GO:0052031)2.21615975
161modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.21615975
162cilium movement (GO:0003341)2.21603654
163macrophage activation involved in immune response (GO:0002281)2.20798553
164lipid translocation (GO:0034204)2.20220059
165phospholipid translocation (GO:0045332)2.20220059
166leukocyte migration involved in inflammatory response (GO:0002523)2.20199673
167negative regulation of myotube differentiation (GO:0010832)2.19605688
168response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.19024611
169plasma lipoprotein particle remodeling (GO:0034369)2.18868643
170protein-lipid complex remodeling (GO:0034368)2.18868643
171macromolecular complex remodeling (GO:0034367)2.18868643
172negative regulation of lymphocyte mediated immunity (GO:0002707)2.18154032
173killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.17948974
174disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.17948974
175definitive hemopoiesis (GO:0060216)2.15571741
176plasma lipoprotein particle organization (GO:0071827)2.14033908
177flavonoid metabolic process (GO:0009812)2.12995062

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.81865198
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.45378656
3* RXR_22158963_ChIP-Seq_LIVER_Mouse3.09371794
4* LXR_22158963_ChIP-Seq_LIVER_Mouse3.03173901
5NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.81350358
6GATA1_22025678_ChIP-Seq_K562_Human2.63199788
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.62670833
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.49053773
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.45069632
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.30793773
11* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.25074853
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.21300587
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.98083430
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.91769335
15CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83783405
16GBX2_23144817_ChIP-Seq_PC3_Human1.78986406
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77854958
18FOXA2_19822575_ChIP-Seq_HepG2_Human1.75930278
19GATA2_21666600_ChIP-Seq_HMVEC_Human1.67131092
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.66292409
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66217799
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62248861
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61070227
24AR_21572438_ChIP-Seq_LNCaP_Human1.60529673
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57550829
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52735947
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52342500
28DROSHA_22980978_ChIP-Seq_HELA_Human1.50757347
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.50102264
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49440253
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48899909
32AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.48296949
33FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.48014906
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48010914
35AHR_22903824_ChIP-Seq_MCF-7_Human1.46894043
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.41959202
37BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.32861906
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32736431
39VDR_24787735_ChIP-Seq_THP-1_Human1.32710207
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.31552844
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.30402054
42CTNNB1_20460455_ChIP-Seq_HCT116_Human1.30337702
43TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.28772241
44PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26622242
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25899508
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.25245718
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24631026
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.23645273
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22763621
50FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21350928
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19228082
52* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17991228
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16046331
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.14903523
55ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14408836
56* TBX20_22328084_ChIP-Seq_HEART_Mouse1.14228020
57* TBX20_22080862_ChIP-Seq_HEART_Mouse1.14228020
58PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13752423
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13645529
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.12732226
61TP53_16413492_ChIP-PET_HCT116_Human1.12562501
62* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.11697154
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11480057
64CLOCK_20551151_ChIP-Seq_293T_Human1.10866541
65STAT3_23295773_ChIP-Seq_U87_Human1.10558534
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09114608
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07954177
68TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06381409
69* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06338491
70SMAD4_21799915_ChIP-Seq_A2780_Human1.06261896
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04012039
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03622854
73TCF4_18268006_ChIP-ChIP_LS174T_Human1.02821904
74TP63_23658742_ChIP-Seq_EP156T_Human1.01520485
75HNF4A_19822575_ChIP-Seq_HepG2_Human1.01124264
76SPI1_23127762_ChIP-Seq_K562_Human0.99748526
77TCF4_23295773_ChIP-Seq_U87_Human0.98907543
78* GATA4_25053715_ChIP-Seq_YYC3_Human0.98881228
79NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98779760
80NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98779760
81PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98022077
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97460728
83ESR2_21235772_ChIP-Seq_MCF-7_Human0.97174424
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97083347
85* ER_23166858_ChIP-Seq_MCF-7_Human0.96737044
86NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94606213
87ESR1_21235772_ChIP-Seq_MCF-7_Human0.94226507
88IRF8_21731497_ChIP-ChIP_J774_Mouse0.94078784
89RUNX_20019798_ChIP-Seq_JUKART_Human0.94032453
90GATA2_19941826_ChIP-Seq_K562_Human0.93053739
91POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92935974
92BCAT_22108803_ChIP-Seq_LS180_Human0.92912400
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92628432
94SCL_19346495_ChIP-Seq_HPC-7_Human0.91688469
95NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90764954
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90034505
97SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89723619
98SOX2_21211035_ChIP-Seq_LN229_Gbm0.89193961
99* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89000081
100* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89000081
101GATA1_19941826_ChIP-Seq_K562_Human0.88898038
102* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87944848
103AR_25329375_ChIP-Seq_VCAP_Human0.87877520
104SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87455445
105RXR_22108803_ChIP-Seq_LS180_Human0.86202662
106CDX2_22108803_ChIP-Seq_LS180_Human0.86185803
107* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86133058
108GATA1_19941827_ChIP-Seq_MEL_Mouse0.86126316
109* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86062106
110EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85955506
111SMAD3_21741376_ChIP-Seq_HESCs_Human0.85876148
112CDX2_20551321_ChIP-Seq_CACO-2_Human0.84422905
113ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.84410471
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83905325
115STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.83686246
116FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.83633628
117FOXA1_25552417_ChIP-Seq_VCAP_Human0.83208993

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.29780016
2MP0005670_abnormal_white_adipose4.25514070
3MP0005365_abnormal_bile_salt4.01472873
4MP0002139_abnormal_hepatobiliary_system3.99784632
5MP0005360_urolithiasis3.94789242
6MP0004130_abnormal_muscle_cell3.25193532
7MP0005085_abnormal_gallbladder_physiolo3.18613967
8MP0002837_dystrophic_cardiac_calcinosis3.04819021
9MP0005666_abnormal_adipose_tissue2.75743335
10MP0010329_abnormal_lipoprotein_level2.69634524
11MP0002009_preneoplasia2.47715456
12MP0003252_abnormal_bile_duct2.45141657
13MP0002254_reproductive_system_inflammat2.39374553
14MP0003303_peritoneal_inflammation2.32159211
15MP0005409_darkened_coat_color2.29626061
16MP0004510_myositis2.15842409
17MP0003191_abnormal_cellular_cholesterol2.13327458
18MP0004185_abnormal_adipocyte_glucose2.03851816
19MP0004264_abnormal_extraembryonic_tissu2.03364186
20MP0008875_abnormal_xenobiotic_pharmacok2.01025745
21MP0005083_abnormal_biliary_tract1.93687447
22MP0004145_abnormal_muscle_electrophysio1.87641553
23MP0002118_abnormal_lipid_homeostasis1.86815388
24MP0002138_abnormal_hepatobiliary_system1.83284009
25MP0003646_muscle_fatigue1.80129366
26MP0005375_adipose_tissue_phenotype1.79084172
27MP0000383_abnormal_hair_follicle1.75657421
28MP0002971_abnormal_brown_adipose1.75566089
29MP0001666_abnormal_nutrient_absorption1.74615269
30MP0004043_abnormal_pH_regulation1.74041874
31MP0003045_fibrosis1.73089512
32MP0000609_abnormal_liver_physiology1.71037796
33MP0004215_abnormal_myocardial_fiber1.69162390
34MP0000465_gastrointestinal_hemorrhage1.68480657
35MP0008004_abnormal_stomach_pH1.67528724
36MP0005334_abnormal_fat_pad1.65191487
37MP0005451_abnormal_body_composition1.62751631
38MP0003868_abnormal_feces_composition1.61921571
39MP0002166_altered_tumor_susceptibility1.61756487
40MP0005076_abnormal_cell_differentiation1.60859396
41MP0010678_abnormal_skin_adnexa1.60473760
42MP0000751_myopathy1.57870104
43MP0005310_abnormal_salivary_gland1.50270430
44MP0002876_abnormal_thyroid_physiology1.50050286
45MP0002132_abnormal_respiratory_system1.49809048
46MP0005647_abnormal_sex_gland1.47405486
47MP0009115_abnormal_fat_cell1.45261077
48MP0004883_abnormal_blood_vessel1.44213736
49MP0008775_abnormal_heart_ventricle1.41352822
50MP0001873_stomach_inflammation1.39872192
51MP0003300_gastrointestinal_ulcer1.38221556
52MP0003866_abnormal_defecation1.36599230
53MP0010155_abnormal_intestine_physiology1.35751293
54MP0003172_abnormal_lysosome_physiology1.34494091
55MP0003436_decreased_susceptibility_to1.32546560
56MP0004084_abnormal_cardiac_muscle1.31792429
57MP0000566_synostosis1.29830041
58MP0003183_abnormal_peptide_metabolism1.29827336
59MP0003656_abnormal_erythrocyte_physiolo1.29147475
60MP0000371_diluted_coat_color1.28596771
61MP0005164_abnormal_response_to1.28312363
62MP0005448_abnormal_energy_balance1.28061509
63MP0002277_abnormal_respiratory_mucosa1.21412913
64MP0001661_extended_life_span1.21407674
65MP0001851_eye_inflammation1.21259325
66MP0003828_pulmonary_edema1.21252633
67MP0002909_abnormal_adrenal_gland1.18022854
68MP0005319_abnormal_enzyme/_coenzyme1.15945413
69MP0005332_abnormal_amino_acid1.15277845
70MP0005330_cardiomyopathy1.14391835
71MP0005174_abnormal_tail_pigmentation1.13771865
72MP0002419_abnormal_innate_immunity1.13679336
73MP0002078_abnormal_glucose_homeostasis1.13614723
74MP0010630_abnormal_cardiac_muscle1.10959421
75MP0005535_abnormal_body_temperature1.09227839
76MP0002972_abnormal_cardiac_muscle1.08709617
77MP0000003_abnormal_adipose_tissue1.07703884
78MP0004782_abnormal_surfactant_physiolog1.06478885
79MP0010352_gastrointestinal_tract_polyps1.06413584
80MP0009840_abnormal_foam_cell1.05591545
81MP0003943_abnormal_hepatobiliary_system1.05421390
82MP0010368_abnormal_lymphatic_system1.05357079
83MP0003690_abnormal_glial_cell1.04993172
84MP0000685_abnormal_immune_system1.04114656
85MP0005385_cardiovascular_system_phenoty1.03614856
86MP0001544_abnormal_cardiovascular_syste1.03614856
87MP0005025_abnormal_response_to1.02467934
88MP0009763_increased_sensitivity_to0.99574066
89MP0008961_abnormal_basal_metabolism0.98591485
90MP0004087_abnormal_muscle_fiber0.97704372
91MP0001765_abnormal_ion_homeostasis0.97057196
92MP0003724_increased_susceptibility_to0.94951764
93MP0002006_tumorigenesis0.92535014
94MP0002970_abnormal_white_adipose0.92407625
95MP0001764_abnormal_homeostasis0.91942638
96MP0004036_abnormal_muscle_relaxation0.90582737
97MP0000249_abnormal_blood_vessel0.89457595
98MP0009764_decreased_sensitivity_to0.89237979
99MP0000427_abnormal_hair_cycle0.88021136
100MP0009697_abnormal_copulation0.87750512
101MP0002928_abnormal_bile_duct0.87446585
102MP0003763_abnormal_thymus_physiology0.87001800
103MP0003950_abnormal_plasma_membrane0.86840211
104MP0002396_abnormal_hematopoietic_system0.86677722
105MP0001800_abnormal_humoral_immune0.86066252
106MP0002106_abnormal_muscle_physiology0.85894737
107MP0005376_homeostasis/metabolism_phenot0.84055004
108MP0001879_abnormal_lymphatic_vessel0.83900366
109MP0002127_abnormal_cardiovascular_syste0.83551795
110MP0005058_abnormal_lysosome_morphology0.83389035
111MP0005620_abnormal_muscle_contractility0.82848942
112MP0005584_abnormal_enzyme/coenzyme_acti0.82597390
113MP0000749_muscle_degeneration0.82052618
114MP0008260_abnormal_autophagy0.81629219
115MP0004484_altered_response_of0.81424215
116MP0005220_abnormal_exocrine_pancreas0.80762304
117MP0002332_abnormal_exercise_endurance0.78649344
118MP0001915_intracranial_hemorrhage0.78610366
119MP0002168_other_aberrant_phenotype0.78222499
120MP0001835_abnormal_antigen_presentation0.76903907
121MP0002405_respiratory_system_inflammati0.76556598
122MP0003195_calcinosis0.76108930
123MP0010234_abnormal_vibrissa_follicle0.75068107
124MP0000015_abnormal_ear_pigmentation0.73804028
125MP0005464_abnormal_platelet_physiology0.73397965
126MP0009765_abnormal_xenobiotic_induced0.72788825
127MP0004381_abnormal_hair_follicle0.72552622
128MP0003890_abnormal_embryonic-extraembry0.71967305
129MP0009643_abnormal_urine_homeostasis0.70973295
130MP0000604_amyloidosis0.70605843
131MP0004147_increased_porphyrin_level0.69759774
132MP0005369_muscle_phenotype0.69462738
133MP0008469_abnormal_protein_level0.69099737
134MP0001790_abnormal_immune_system0.67190809
135MP0005387_immune_system_phenotype0.67190809
136MP0002108_abnormal_muscle_morphology0.67095435
137MP0003705_abnormal_hypodermis_morpholog0.65780363
138MP0003221_abnormal_cardiomyocyte_apopto0.65533214
139MP0006138_congestive_heart_failure0.65522907
140MP0001845_abnormal_inflammatory_respons0.65470603
141MP0005645_abnormal_hypothalamus_physiol0.65402867
142MP0005167_abnormal_blood-brain_barrier0.64764362
143MP0005397_hematopoietic_system_phenotyp0.64459298
144MP0003959_abnormal_lean_body0.64113125
145MP0009278_abnormal_bone_marrow0.63711304

Predicted human phenotypes

RankGene SetZ-score
1Epidermoid cyst (HP:0200040)3.69714403
2Right ventricular cardiomyopathy (HP:0011663)3.61436571
3Hypoglycemic coma (HP:0001325)3.57892494
4Papillary thyroid carcinoma (HP:0002895)3.33042590
5Hypoalphalipoproteinemia (HP:0003233)3.32911465
6Hyperkalemia (HP:0002153)3.28659323
7Intrahepatic cholestasis (HP:0001406)3.19019711
8Ketosis (HP:0001946)3.16824707
9Exercise-induced myalgia (HP:0003738)3.14177531
10Eczematoid dermatitis (HP:0000976)3.11264973
11Absent/shortened dynein arms (HP:0200106)3.10801006
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.10801006
13Abnormality of proline metabolism (HP:0010907)3.08034673
14Hydroxyprolinuria (HP:0003080)3.08034673
15Abnormality of glutamine family amino acid metabolism (HP:0010902)3.07801324
16Hyperglycinuria (HP:0003108)3.01696297
17Flat acetabular roof (HP:0003180)3.01375582
18Glomerulonephritis (HP:0000099)2.97562073
19Abnormality of complement system (HP:0005339)2.97319305
20Xanthomatosis (HP:0000991)2.97238705
21Sudden death (HP:0001699)2.95703446
22Abnormal ciliary motility (HP:0012262)2.87203027
23Hyperlipoproteinemia (HP:0010980)2.87168519
24Abnormality of the fingertips (HP:0001211)2.86288872
25Ketoacidosis (HP:0001993)2.85127939
26Ventricular tachycardia (HP:0004756)2.82899695
27Conjugated hyperbilirubinemia (HP:0002908)2.82784748
28Syncope (HP:0001279)2.82660562
29Abnormality of fatty-acid metabolism (HP:0004359)2.81691634
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.79151034
31Abnormal respiratory motile cilium morphology (HP:0005938)2.78725070
32Abnormal respiratory epithelium morphology (HP:0012253)2.78725070
33Atrial fibrillation (HP:0005110)2.77520744
34Muscle fiber inclusion bodies (HP:0100299)2.76759756
35Complement deficiency (HP:0004431)2.76488113
36Hypercholesterolemia (HP:0003124)2.73258289
37Myoglobinuria (HP:0002913)2.67528210
38Hyperactive renin-angiotensin system (HP:0000841)2.65991952
39Skin nodule (HP:0200036)2.65709670
40Abnormal respiratory motile cilium physiology (HP:0012261)2.65623883
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.64436364
42Nemaline bodies (HP:0003798)2.61890737
43Hyperammonemia (HP:0001987)2.61874103
44Deep venous thrombosis (HP:0002625)2.61680716
45Rhinitis (HP:0012384)2.60637275
46Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.57984061
47Gingival bleeding (HP:0000225)2.57476198
48Joint hemorrhage (HP:0005261)2.56693689
49Hyperglycemia (HP:0003074)2.55741983
50Insulin-resistant diabetes mellitus (HP:0000831)2.54864029
51Renal cortical cysts (HP:0000803)2.54078714
52Hyporeflexia of lower limbs (HP:0002600)2.53427744
53Hypoglycemic seizures (HP:0002173)2.51973797
54Abnormality of the nasal septum (HP:0000419)2.50788367
55Hematochezia (HP:0002573)2.50617524
56Prolonged partial thromboplastin time (HP:0003645)2.50043315
57Hypolipoproteinemia (HP:0010981)2.49268826
58Myocardial infarction (HP:0001658)2.47969724
59Primary atrial arrhythmia (HP:0001692)2.47813006
60Pigmentary retinal degeneration (HP:0001146)2.46791312
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.44693891
62Bronchiectasis (HP:0002110)2.44406912
63Prostate neoplasm (HP:0100787)2.44242627
64Hypertriglyceridemia (HP:0002155)2.42184020
65Muscle hypertrophy of the lower extremities (HP:0008968)2.39310265
66Hypobetalipoproteinemia (HP:0003563)2.37331018
67Calf muscle hypertrophy (HP:0008981)2.37054453
68Myositis (HP:0100614)2.34324546
69Oligomenorrhea (HP:0000876)2.33920197
70Abnormality of glycine metabolism (HP:0010895)2.31573929
71Abnormality of serine family amino acid metabolism (HP:0010894)2.31573929
72Orchitis (HP:0100796)2.29627412
73Decreased circulating renin level (HP:0003351)2.29443779
74Abnormality of sulfur amino acid metabolism (HP:0004339)2.28743670
75Lipoatrophy (HP:0100578)2.27703602
76Retrobulbar optic neuritis (HP:0100654)2.24879328
77Optic neuritis (HP:0100653)2.24879328
78Systemic lupus erythematosus (HP:0002725)2.24715650
79Muscle fiber splitting (HP:0003555)2.24514184
80Supraventricular tachycardia (HP:0004755)2.23962201
81Abnormality of monocarboxylic acid metabolism (HP:0010996)2.22767264
82Gastrointestinal infarctions (HP:0005244)2.22283921
83Supraventricular arrhythmia (HP:0005115)2.20489937
84Abnormality of vision evoked potentials (HP:0000649)2.17788492
85Dicarboxylic aciduria (HP:0003215)2.17303893
86Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17303893
87Nephritis (HP:0000123)2.15578819
88Esophageal varix (HP:0002040)2.15049236
89Chronic bronchitis (HP:0004469)2.14942075
90Keratoconjunctivitis (HP:0001096)2.14766108
91Hyperinsulinemic hypoglycemia (HP:0000825)2.14472835
92Spontaneous hematomas (HP:0007420)2.13546366
93Dilated cardiomyopathy (HP:0001644)2.13408279
94Recurrent bacterial skin infections (HP:0005406)2.12586571
95Prolonged QT interval (HP:0001657)2.12528641
96Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10912598
97Recurrent abscess formation (HP:0002722)2.09078066
98Toxemia of pregnancy (HP:0100603)2.07986193
99Abnormality of purine metabolism (HP:0004352)2.06715180
100Long toe (HP:0010511)2.04974363
101Difficulty running (HP:0009046)2.02144078
102Tetraparesis (HP:0002273)2.01358299
103Macroorchidism (HP:0000053)2.00814459
104Thick nail (HP:0001805)2.00708120
105Periodontitis (HP:0000704)2.00431095
106Gingivitis (HP:0000230)1.99252167
107Abnormality of chloride homeostasis (HP:0011422)1.97257656
108Subaortic stenosis (HP:0001682)1.95951076
109Abnormality of the left ventricular outflow tract (HP:0011103)1.95951076
110Palpitations (HP:0001962)1.95465898
111Prolonged bleeding time (HP:0003010)1.95029459
112Hemorrhage of the eye (HP:0011885)1.93837738
113Abnormality of the common coagulation pathway (HP:0010990)1.91542185
114Pulmonary embolism (HP:0002204)1.90738990
115Increased connective tissue (HP:0009025)1.89773126
116Nausea (HP:0002018)1.88533875
117Spontaneous abortion (HP:0005268)1.88095775
118Central scotoma (HP:0000603)1.87765317
119Frequent falls (HP:0002359)1.87497968
120Recurrent sinusitis (HP:0011108)1.87300605
121Amyloidosis (HP:0011034)1.87284314
122Cholelithiasis (HP:0001081)1.86548836
123Hypoplastic ischia (HP:0003175)1.85061289
124Chronic mucocutaneous candidiasis (HP:0002728)1.84547401
125Recurrent cutaneous fungal infections (HP:0011370)1.84547401
126Abnormality of the renal cortex (HP:0011035)1.84269196
127Turricephaly (HP:0000262)1.83762958
128Abnormality of nucleobase metabolism (HP:0010932)1.83366226
129Portal hypertension (HP:0001409)1.82974912
130Recurrent gram-negative bacterial infections (HP:0005420)1.82586045
131Hypochromic microcytic anemia (HP:0004840)1.82491574
132Rhabdomyolysis (HP:0003201)1.82311056
133Colitis (HP:0002583)1.81904335
134Symptomatic seizures (HP:0011145)1.81556366
135Long foot (HP:0001833)1.81232399
136Autoimmune thrombocytopenia (HP:0001973)1.81058652
137Osteomalacia (HP:0002749)1.80929567
138Abnormality of aromatic amino acid family metabolism (HP:0004338)1.80896815
139Thyroid carcinoma (HP:0002890)1.80175384
140Heterotopia (HP:0002282)1.79477672
141Keratoconjunctivitis sicca (HP:0001097)1.79087031
142Visceral angiomatosis (HP:0100761)1.78849872
143Abnormality of the distal phalanx of the thumb (HP:0009617)1.78638604
144Germ cell neoplasia (HP:0100728)1.77798517
145Abnormality of methionine metabolism (HP:0010901)1.77560888
146Neonatal hypoglycemia (HP:0001998)1.76846512
147Ventricular arrhythmia (HP:0004308)1.76517426
148Abnormality of the intrinsic pathway (HP:0010989)1.75848870
149Pancreatitis (HP:0001733)1.75834977
150Hypoplasia of the thymus (HP:0000778)1.75121086
151Malnutrition (HP:0004395)1.75113963
152Metabolic acidosis (HP:0001942)1.75041157
153Truncal obesity (HP:0001956)1.74612979
154Urethral obstruction (HP:0000796)1.73611175
155Subacute progressive viral hepatitis (HP:0006572)1.73420949
156Fat malabsorption (HP:0002630)1.73406506
157Thrombophlebitis (HP:0004418)1.73372973
158Bundle branch block (HP:0011710)1.73300843
159Epistaxis (HP:0000421)1.72778733
160Hepatoblastoma (HP:0002884)1.72326904
161Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.71987855
162Fair hair (HP:0002286)1.71262732
163Abnormality of potassium homeostasis (HP:0011042)1.70007313
164Genetic anticipation (HP:0003743)1.69490439
165Abnormality of secondary sexual hair (HP:0009888)1.67267252
166Abnormality of the axillary hair (HP:0100134)1.67267252
167Tubulointerstitial nephritis (HP:0001970)1.66928587
168Recurrent skin infections (HP:0001581)1.66619030
169Arterial thrombosis (HP:0004420)1.66147246
170Neoplasm of the tracheobronchial system (HP:0100552)1.65933031
171Laryngomalacia (HP:0001601)1.63243421
172Hemangiomatosis (HP:0007461)1.62020445
173Bifid scrotum (HP:0000048)1.62004425
174Dysmetric saccades (HP:0000641)1.61219368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D4.01139749
2INSRR3.51806362
3CAMK1G3.22828299
4IRAK32.98017401
5MAP3K142.47993484
6SIK12.35520893
7TAOK32.33734590
8LMTK22.02205071
9TTN1.98545682
10NLK1.97291910
11JAK11.91702542
12LATS11.86140481
13FRK1.79370438
14DAPK21.75521962
15TYK21.75479436
16BCKDK1.74908594
17MAP3K131.73773098
18CDK121.73297239
19MAP3K21.69160562
20PRKAA21.68066963
21IKBKE1.65755999
22MAP2K31.63214162
23PIK3CG1.62318608
24BLK1.57963643
25TNK21.51568799
26FGFR41.51360935
27TAOK11.49048158
28EEF2K1.41253956
29MAP3K71.39999856
30SGK21.38302423
31PTK61.35886863
32BRD41.34990446
33PKN21.32556431
34SGK31.31750287
35FGFR31.26021384
36RIPK11.23106553
37SIK21.21352001
38JAK31.17017729
39PRKAA11.14625954
40FLT31.09932488
41MAPK151.09756787
42FES1.09746803
43ERN11.09558282
44ZAK1.08939859
45TRPM71.07136287
46TEC1.06093802
47TIE11.06016367
48ACVR1B1.04217507
49OBSCN1.02536160
50NUAK11.01264016
51MAP2K41.01214140
52CHUK1.00425532
53PHKG20.99015153
54PHKG10.99015153
55PIK3CA0.97600462
56IRAK40.95670570
57TBK10.94374201
58STK390.94313687
59PDK40.93253131
60PDK30.93253131
61MST1R0.90254263
62ZAP700.88868854
63PRPF4B0.86486874
64JAK20.85324427
65CDK90.84653402
66KIT0.84035935
67MAP3K30.82657413
68SGK10.81706325
69CDK60.81089694
70STK110.80886889
71MTOR0.80806911
72BTK0.80479370
73PKN10.77412780
74TGFBR20.73173220
75NEK90.72780016
76EIF2AK20.72555421
77PDGFRB0.71239885
78DMPK0.70610762
79FGR0.70560552
80FER0.70537550
81SGK2230.69802803
82SGK4940.69802803
83IRAK20.69761837
84MAP2K60.67960255
85PRKD20.66515050
86MAP3K10.66367009
87MELK0.65052504
88NTRK30.64894103
89STK240.64549447
90TRIB30.64299798
91HIPK20.63612282
92MARK20.63542704
93FGFR20.62920227
94IKBKB0.62630928
95CAMK40.61738678
96ERBB20.61571206
97MAPK110.60275366
98MAP3K60.60215624
99STK380.59754482
100EPHA30.59156754
101MAP4K10.58672543
102CDC42BPA0.58347781
103ITK0.58066863
104MAPK120.57821008
105HCK0.57689472
106MAPK70.57563419
107PINK10.55600477
108TXK0.55412432
109ICK0.54413318
110OXSR10.53996792
111IRAK10.52533255
112MAP3K40.50908366
113EPHB10.50457429
114YES10.50090005
115WNK10.49294207
116CSK0.49230835
117GRK60.48275452
118LCK0.48225678
119LYN0.47576082
120SYK0.47573713
121RIPK40.47451098
122AKT30.46385880
123STK30.44911939
124RET0.43926263
125CAMK2D0.42853752
126PDGFRA0.41728551
127PRKACG0.41202031
128PTK20.41127636
129CSF1R0.40824679
130CAMK10.40554631
131PTK2B0.40195655
132PDK10.38473793
133GSK3A0.37839144
134PRKD10.36678243
135EGFR0.36455269
136PDPK10.34989179
137PRKCH0.34978448

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid degradation_Homo sapiens_hsa000712.92606423
2Propanoate metabolism_Homo sapiens_hsa006402.88665238
3PPAR signaling pathway_Homo sapiens_hsa033202.66943355
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.63268292
5Fatty acid metabolism_Homo sapiens_hsa012122.42905142
6Lysine degradation_Homo sapiens_hsa003102.19068343
7Arginine biosynthesis_Homo sapiens_hsa002202.17661773
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.15286634
9Caffeine metabolism_Homo sapiens_hsa002322.14627405
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.11520893
11Tryptophan metabolism_Homo sapiens_hsa003802.05347383
12Fatty acid biosynthesis_Homo sapiens_hsa000612.04430223
13ABC transporters_Homo sapiens_hsa020102.02683128
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.72786573
15Nitrogen metabolism_Homo sapiens_hsa009101.63777387
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60035990
17Type II diabetes mellitus_Homo sapiens_hsa049301.59087735
18beta-Alanine metabolism_Homo sapiens_hsa004101.58613955
19Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.53116057
20Complement and coagulation cascades_Homo sapiens_hsa046101.52160326
21Butanoate metabolism_Homo sapiens_hsa006501.51078033
22Fat digestion and absorption_Homo sapiens_hsa049751.47720153
23Peroxisome_Homo sapiens_hsa041461.47268136
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.45857779
25Glycerolipid metabolism_Homo sapiens_hsa005611.43549642
26Staphylococcus aureus infection_Homo sapiens_hsa051501.41836070
27Insulin resistance_Homo sapiens_hsa049311.40942181
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.38150303
29Linoleic acid metabolism_Homo sapiens_hsa005911.35592844
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.27218483
31Starch and sucrose metabolism_Homo sapiens_hsa005001.23840098
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19828495
33Pyruvate metabolism_Homo sapiens_hsa006201.17395704
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15715084
35Circadian rhythm_Homo sapiens_hsa047101.14889424
36Bile secretion_Homo sapiens_hsa049761.13540137
37AMPK signaling pathway_Homo sapiens_hsa041521.10597482
38Histidine metabolism_Homo sapiens_hsa003401.06823630
39Phenylalanine metabolism_Homo sapiens_hsa003601.04556457
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99885501
41Platelet activation_Homo sapiens_hsa046110.99688158
42Carbon metabolism_Homo sapiens_hsa012000.99663223
43Choline metabolism in cancer_Homo sapiens_hsa052310.97904940
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95075130
45Non-small cell lung cancer_Homo sapiens_hsa052230.94216545
46Prostate cancer_Homo sapiens_hsa052150.93420875
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93024509
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92655487
49Endometrial cancer_Homo sapiens_hsa052130.91457571
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.91104213
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.88468762
52Dilated cardiomyopathy_Homo sapiens_hsa054140.88386417
53Vitamin digestion and absorption_Homo sapiens_hsa049770.87159912
54Insulin signaling pathway_Homo sapiens_hsa049100.85393331
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.83358588
56Renin-angiotensin system_Homo sapiens_hsa046140.83064411
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82198686
58Leishmaniasis_Homo sapiens_hsa051400.81247438
59Pancreatic secretion_Homo sapiens_hsa049720.80796803
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80193388
61Glucagon signaling pathway_Homo sapiens_hsa049220.79720157
62Selenocompound metabolism_Homo sapiens_hsa004500.79075788
63Retinol metabolism_Homo sapiens_hsa008300.76062988
64GnRH signaling pathway_Homo sapiens_hsa049120.75616486
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75548995
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73224980
67Arachidonic acid metabolism_Homo sapiens_hsa005900.72724200
68Thyroid hormone synthesis_Homo sapiens_hsa049180.72552866
69Ovarian steroidogenesis_Homo sapiens_hsa049130.71721077
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71050100
71Adherens junction_Homo sapiens_hsa045200.70865014
72Pancreatic cancer_Homo sapiens_hsa052120.69944726
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69762575
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69332657
75Tyrosine metabolism_Homo sapiens_hsa003500.69226951
76Fatty acid elongation_Homo sapiens_hsa000620.68360944
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67931081
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.67835466
79Amoebiasis_Homo sapiens_hsa051460.67194620
80Inositol phosphate metabolism_Homo sapiens_hsa005620.66986593
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65806191
82Notch signaling pathway_Homo sapiens_hsa043300.65589595
83Chronic myeloid leukemia_Homo sapiens_hsa052200.64746119
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63804523
85Renal cell carcinoma_Homo sapiens_hsa052110.62759343
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59539386
87Influenza A_Homo sapiens_hsa051640.58982124
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.58942341
89Osteoclast differentiation_Homo sapiens_hsa043800.58363756
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.57591678
91Hepatitis C_Homo sapiens_hsa051600.56888498
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56610327
93T cell receptor signaling pathway_Homo sapiens_hsa046600.56362416
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53598918
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52832641
96Dorso-ventral axis formation_Homo sapiens_hsa043200.52584944
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.52067942
98Pertussis_Homo sapiens_hsa051330.52038530
99African trypanosomiasis_Homo sapiens_hsa051430.51349287
100Chemical carcinogenesis_Homo sapiens_hsa052040.50901541
101VEGF signaling pathway_Homo sapiens_hsa043700.50775420
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.50730949
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49511375
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49500530
105Estrogen signaling pathway_Homo sapiens_hsa049150.49451645
106ErbB signaling pathway_Homo sapiens_hsa040120.49253497
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.48781455
108Long-term depression_Homo sapiens_hsa047300.48186704
109TNF signaling pathway_Homo sapiens_hsa046680.47181655
110Fructose and mannose metabolism_Homo sapiens_hsa000510.47164065
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47023186
112Measles_Homo sapiens_hsa051620.46453746
113Toxoplasmosis_Homo sapiens_hsa051450.46162519
114Viral myocarditis_Homo sapiens_hsa054160.45892853
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45551418
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45428899
117Renin secretion_Homo sapiens_hsa049240.42657613
118Small cell lung cancer_Homo sapiens_hsa052220.42452730
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41830904
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40467708
121Acute myeloid leukemia_Homo sapiens_hsa052210.39062920
122mTOR signaling pathway_Homo sapiens_hsa041500.37137966
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35040585
124Prolactin signaling pathway_Homo sapiens_hsa049170.33255834
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30997777
126cAMP signaling pathway_Homo sapiens_hsa040240.30406651
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28656481
128Mineral absorption_Homo sapiens_hsa049780.28576481
129B cell receptor signaling pathway_Homo sapiens_hsa046620.28081092
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.27161318
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.26763023
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26591963
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25753652
134Intestinal immune network for IgA production_Homo sapiens_hsa046720.23973413
135Tuberculosis_Homo sapiens_hsa051520.23197301
136Biosynthesis of amino acids_Homo sapiens_hsa012300.22184206
137FoxO signaling pathway_Homo sapiens_hsa040680.21678598

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