RALGAPB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.29875095
2locomotory exploration behavior (GO:0035641)4.50454739
3nuclear pore organization (GO:0006999)4.34042612
4synaptic vesicle maturation (GO:0016188)4.18272173
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.12620242
6histone H3-K36 demethylation (GO:0070544)3.90466436
7regulation of RNA export from nucleus (GO:0046831)3.88899585
8sodium ion export (GO:0071436)3.81614781
9pore complex assembly (GO:0046931)3.81520208
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.72783334
11layer formation in cerebral cortex (GO:0021819)3.69479938
12regulation of histone H3-K27 methylation (GO:0061085)3.59579862
13Golgi transport vesicle coating (GO:0048200)3.57416089
14COPI coating of Golgi vesicle (GO:0048205)3.57416089
15cellular potassium ion homeostasis (GO:0030007)3.56078547
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.53530376
17regulation of clathrin-mediated endocytosis (GO:2000369)3.46699820
18protein localization to endosome (GO:0036010)3.41052283
19cytoskeletal anchoring at plasma membrane (GO:0007016)3.36447790
20synaptic vesicle docking involved in exocytosis (GO:0016081)3.35407827
21regulation of ARF protein signal transduction (GO:0032012)3.34797477
22embryonic process involved in female pregnancy (GO:0060136)3.31833733
23desmosome organization (GO:0002934)3.30618984
24establishment of nucleus localization (GO:0040023)3.27949870
25cytoplasmic mRNA processing body assembly (GO:0033962)3.23432431
26histone H3-K9 demethylation (GO:0033169)3.20586577
27mitotic sister chromatid cohesion (GO:0007064)3.20175303
28phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.16530423
29COPII vesicle coating (GO:0048208)3.14237329
30cerebellar Purkinje cell differentiation (GO:0021702)3.12614702
31neuromuscular process controlling balance (GO:0050885)3.12528623
32cell-substrate junction assembly (GO:0007044)3.08898965
33regulation of synaptic vesicle exocytosis (GO:2000300)3.05808128
34synaptic vesicle exocytosis (GO:0016079)3.04625106
35cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.04508603
36histone lysine demethylation (GO:0070076)3.03548386
37activation of protein kinase A activity (GO:0034199)3.03452521
38cell-substrate adherens junction assembly (GO:0007045)3.01723945
39focal adhesion assembly (GO:0048041)3.01723945
40glutamate secretion (GO:0014047)2.96833585
41hemidesmosome assembly (GO:0031581)2.95672031
42nerve growth factor signaling pathway (GO:0038180)2.95061447
43signal complex assembly (GO:0007172)2.94606852
44adherens junction assembly (GO:0034333)2.94570748
45dendrite morphogenesis (GO:0048813)2.94301680
46vesicle transport along microtubule (GO:0047496)2.93929291
47skin morphogenesis (GO:0043589)2.92709741
48glucocorticoid receptor signaling pathway (GO:0042921)2.92303520
49NLS-bearing protein import into nucleus (GO:0006607)2.88520680
50negative regulation of DNA repair (GO:0045738)2.86388896
51histone demethylation (GO:0016577)2.84611855
52positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.83933472
53protein targeting to Golgi (GO:0000042)2.83132088
54exploration behavior (GO:0035640)2.82755590
55vocalization behavior (GO:0071625)2.82118776
56synaptic vesicle endocytosis (GO:0048488)2.81910023
57regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.81415133
58vesicle coating (GO:0006901)2.80093214
59regulation of ARF GTPase activity (GO:0032312)2.78554596
60establishment of protein localization to Golgi (GO:0072600)2.78047314
61proline transport (GO:0015824)2.77685365
62regulation of glutamate receptor signaling pathway (GO:1900449)2.77627106
63regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.74890215
64regulation of synapse structural plasticity (GO:0051823)2.73297245
65cell communication by electrical coupling (GO:0010644)2.71485620
66positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.70877897
67retrograde transport, vesicle recycling within Golgi (GO:0000301)2.70799127
68negative regulation of fatty acid transport (GO:2000192)2.70245675
69iron ion import (GO:0097286)2.69812135
70potassium ion import (GO:0010107)2.69326166
71cell adhesion mediated by integrin (GO:0033627)2.67209502
72peptidyl-threonine phosphorylation (GO:0018107)2.64996342
73protein localization to microtubule (GO:0035372)2.64591006
74positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.64565254
75retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.63822369
76regulation of dendritic spine morphogenesis (GO:0061001)2.62850874
77membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.61880368
78neurotransmitter secretion (GO:0007269)2.61526767
79negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.60523241
80corticosteroid receptor signaling pathway (GO:0031958)2.59957269
81dendritic spine morphogenesis (GO:0060997)2.59893187
82regulation of neuronal synaptic plasticity (GO:0048168)2.56671696
83peptidyl-threonine modification (GO:0018210)2.56458153
84regulation of synaptic vesicle transport (GO:1902803)2.55993011
85ionotropic glutamate receptor signaling pathway (GO:0035235)2.55877319
86embryonic camera-type eye morphogenesis (GO:0048596)2.54935539
87hippo signaling (GO:0035329)2.53258989
88regulation of transforming growth factor beta2 production (GO:0032909)2.52790605
89pre-miRNA processing (GO:0031054)2.52689615
90regulation of long-term neuronal synaptic plasticity (GO:0048169)2.52134158
91negative regulation of anoikis (GO:2000811)2.51333815
92regulation of cAMP-dependent protein kinase activity (GO:2000479)2.51166944
93cell migration in hindbrain (GO:0021535)2.50354467
94response to epidermal growth factor (GO:0070849)2.50237267
95response to laminar fluid shear stress (GO:0034616)2.50166511
96regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.49503880
97stress fiber assembly (GO:0043149)2.48540340
98organelle transport along microtubule (GO:0072384)2.47190519
99clathrin coat assembly (GO:0048268)2.44303105
100bundle of His cell to Purkinje myocyte communication (GO:0086069)2.44278505
101regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.43209071
102positive regulation of dendritic spine morphogenesis (GO:0061003)2.43170026
103regulation of NFAT protein import into nucleus (GO:0051532)2.43088291
104peptidyl-lysine dimethylation (GO:0018027)2.42375769
105protein demethylation (GO:0006482)2.41270769
106protein dealkylation (GO:0008214)2.41270769
107cellular sodium ion homeostasis (GO:0006883)2.40523667
108embryonic eye morphogenesis (GO:0048048)2.40305304
109potassium ion homeostasis (GO:0055075)2.39513629
110hypotonic response (GO:0006971)2.38266443
111basement membrane organization (GO:0071711)2.37160599
112histone H3-K4 trimethylation (GO:0080182)2.37148632
113prepulse inhibition (GO:0060134)2.37120046
114activation of Rac GTPase activity (GO:0032863)2.34777961
115regulation of protein polyubiquitination (GO:1902914)2.33723155
116glycine transport (GO:0015816)2.33682559
117protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.31924013
118regulation of excitatory postsynaptic membrane potential (GO:0060079)2.31757433
119long-term memory (GO:0007616)2.29870933
120cellular response to nerve growth factor stimulus (GO:1990090)2.29658624
121response to nerve growth factor (GO:1990089)2.29658624
122positive regulation of cellular response to insulin stimulus (GO:1900078)2.28566843
123dosage compensation (GO:0007549)2.27504461
124neuromuscular process (GO:0050905)2.27172096
125cell communication involved in cardiac conduction (GO:0086065)2.26649880
126embryonic retina morphogenesis in camera-type eye (GO:0060059)2.26581596
127cellular response to epidermal growth factor stimulus (GO:0071364)2.26196383
128mammary gland epithelial cell proliferation (GO:0033598)2.25899615
129membrane depolarization during action potential (GO:0086010)2.25565515
130monoubiquitinated protein deubiquitination (GO:0035520)2.25241367
131negative regulation of cell killing (GO:0031342)2.24353706
132negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.24353706
133innervation (GO:0060384)2.23975640
134protein export from nucleus (GO:0006611)2.23961121
135gamma-aminobutyric acid transport (GO:0015812)2.23358568
136membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.23081618
137plasma membrane repair (GO:0001778)2.22788196
138regulation of postsynaptic membrane potential (GO:0060078)2.22511231
139coronary vasculature morphogenesis (GO:0060977)2.20817154
140stress granule assembly (GO:0034063)2.20728266
141regulation of early endosome to late endosome transport (GO:2000641)2.20689132
142mRNA stabilization (GO:0048255)2.20460795
143RNA stabilization (GO:0043489)2.20460795
144cortical actin cytoskeleton organization (GO:0030866)2.20026518
145regulation of Rap GTPase activity (GO:0032317)2.20009772
146chondrocyte development (GO:0002063)2.19026375
147membrane repolarization (GO:0086009)2.18982140
148N-glycan processing (GO:0006491)2.18566151
149regulation of glucose import in response to insulin stimulus (GO:2001273)2.18305279
150epithelial cell differentiation involved in prostate gland development (GO:0060742)2.18102013
151Golgi to endosome transport (GO:0006895)2.18046182
152semaphorin-plexin signaling pathway (GO:0071526)2.17892523
153protein localization to synapse (GO:0035418)2.17806390
154positive regulation of synapse maturation (GO:0090129)2.17301075
155glutamate receptor signaling pathway (GO:0007215)2.17007174
156insulin-like growth factor receptor signaling pathway (GO:0048009)2.16558874
157negative regulation of histone methylation (GO:0031061)2.16390348
158membrane protein ectodomain proteolysis (GO:0006509)2.15792226
159positive regulation of Rap GTPase activity (GO:0032854)2.15679259
160paraxial mesoderm development (GO:0048339)2.15672836
161regulation of cholesterol homeostasis (GO:2000188)2.15590652
162regulation of nucleobase-containing compound transport (GO:0032239)2.14987302
163macroautophagy (GO:0016236)2.14857490
164G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.14361211
165chemosensory behavior (GO:0007635)2.14026659
166suckling behavior (GO:0001967)2.13985152
167cellular response to ethanol (GO:0071361)2.13861571
168epithelial cell-cell adhesion (GO:0090136)2.13035512
169protein targeting to vacuole (GO:0006623)2.12779157
170protein targeting to lysosome (GO:0006622)2.12779157
171establishment of protein localization to vacuole (GO:0072666)2.12779157
172lipid translocation (GO:0034204)2.12392062
173phospholipid translocation (GO:0045332)2.12392062
174peptidyl-serine phosphorylation (GO:0018105)2.11453333
175regulation of anoikis (GO:2000209)2.09349512
176Golgi organization (GO:0007030)2.09245828
177histone H3-K4 methylation (GO:0051568)2.08891143
178positive regulation of macroautophagy (GO:0016239)2.08350385
179morphogenesis of an epithelial sheet (GO:0002011)2.06149374
180interkinetic nuclear migration (GO:0022027)2.05141671
181negative regulation of keratinocyte proliferation (GO:0010839)2.02744280
182trophectodermal cell differentiation (GO:0001829)2.02099829
183branching involved in mammary gland duct morphogenesis (GO:0060444)2.01549484

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.75152167
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.07622617
3EZH2_22144423_ChIP-Seq_EOC_Human2.86940095
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.77056924
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42151062
6DROSHA_22980978_ChIP-Seq_HELA_Human2.38302499
7CLOCK_20551151_ChIP-Seq_293T_Human2.22087189
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.21961543
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.15487286
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07904214
11E2F7_22180533_ChIP-Seq_HELA_Human2.05252238
12TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.96271915
13KDM2B_26808549_Chip-Seq_K562_Human1.91235128
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.88918263
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.88431288
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.85602352
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81601954
18SOX9_24532713_ChIP-Seq_HFSC_Mouse1.78833134
19KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78444971
20SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.73542015
21ZFP281_27345836_Chip-Seq_ESCs_Mouse1.71646555
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.71368654
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.71368654
24SALL4_18804426_ChIP-ChIP_XEN_Mouse1.70037341
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69857562
26KDM2B_26808549_Chip-Seq_DND41_Human1.69715826
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69308496
28AR_21572438_ChIP-Seq_LNCaP_Human1.69272843
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.68576444
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.65879737
31AR_21909140_ChIP-Seq_LNCAP_Human1.63235958
32DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.62848877
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62672630
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61046076
35SOX2_27498859_Chip-Seq_STOMACH_Mouse1.61003936
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.58611220
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58149710
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57905868
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.57181864
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56339337
41* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.56202849
42ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.54140305
43MYC_22102868_ChIP-Seq_BL_Human1.53406524
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52470239
45SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.51562207
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51004981
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50886869
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.50691437
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50192951
50REST_21632747_ChIP-Seq_MESCs_Mouse1.48915184
51WT1_25993318_ChIP-Seq_PODOCYTE_Human1.48575931
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.47419982
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.47419982
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.46422864
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46382266
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.44296335
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43860318
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42741935
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.41586311
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.40800022
61NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39909258
62* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.38385100
63GBX2_23144817_ChIP-Seq_PC3_Human1.38380677
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38281758
65EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37493334
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.37433175
67CTNNB1_20460455_ChIP-Seq_HCT116_Human1.37266896
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36602030
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.36280324
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35631357
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35441339
72AHR_22903824_ChIP-Seq_MCF-7_Human1.35427226
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34535333
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.32037462
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31796280
76* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29520524
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29455302
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.28578603
79TBX20_22080862_ChIP-Seq_HEART_Mouse1.27891077
80TBX20_22328084_ChIP-Seq_HEART_Mouse1.27891077
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.27276516
82CHD1_26751641_Chip-Seq_LNCaP_Human1.26953717
83MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26700914
84* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26394653
85RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25880465
86AR_19668381_ChIP-Seq_PC3_Human1.25442313
87TCF7_22412390_ChIP-Seq_EML_Mouse1.24932376
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23815900
89NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23406279
90TP53_16413492_ChIP-PET_HCT116_Human1.23368101
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22744438
92SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22492442
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.21478408
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21413389
95JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20703103
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19019552
97SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18792176
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18168493
99REST_18959480_ChIP-ChIP_MESCs_Mouse1.16328711
100BRD4_25478319_ChIP-Seq_HGPS_Human1.15490289
101SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15330202
102SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14828399
103ESR1_21235772_ChIP-Seq_MCF-7_Human1.14724638
104PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.14458994
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12561868
106SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12561738
107ESR2_21235772_ChIP-Seq_MCF-7_Human1.11664755
108NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11338187
109FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11295554
110RING1B_27294783_Chip-Seq_NPCs_Mouse1.10391093
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10264457
112EP300_21415370_ChIP-Seq_HL-1_Mouse1.10213133
113SOX2_21211035_ChIP-Seq_LN229_Gbm1.10027757
114IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09926436
115UBF1/2_26484160_Chip-Seq_HMECs_Human1.09797454
116YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08643130
117STAT3_23295773_ChIP-Seq_U87_Human1.08165218
118STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08163570
119ZNF274_21170338_ChIP-Seq_K562_Hela1.06774800
120CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06577740
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06383185
122RACK7_27058665_Chip-Seq_MCF-7_Human1.06022342
123RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05487964
124GATA6_25053715_ChIP-Seq_YYC3_Human1.04654845
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04295911
126LXR_22292898_ChIP-Seq_THP-1_Human1.03465756
127FOXO3_23340844_ChIP-Seq_DLD1_Human1.02669120
128FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02427376
129SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00349906
130* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00217054
131CREB1_26743006_Chip-Seq_LNCaP_Human1.00181918
132ZNF263_19887448_ChIP-Seq_K562_Human1.00014052
133* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99929241
134RXR_22108803_ChIP-Seq_LS180_Human0.99806858
135SMAD4_21799915_ChIP-Seq_A2780_Human0.99651000
136EZH2_27294783_Chip-Seq_ESCs_Mouse0.99184754
137EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98943434
138ISL1_27105846_Chip-Seq_CPCs_Mouse0.98895435
139RUNX1_27514584_Chip-Seq_MCF-7_Human0.98719145
140ELK3_25401928_ChIP-Seq_HUVEC_Human0.97493106
141FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97171574
142PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95796252
143FOXA2_19822575_ChIP-Seq_HepG2_Human0.95381722
144EGR1_19374776_ChIP-ChIP_THP-1_Human0.95059305
145RING1B_27294783_Chip-Seq_ESCs_Mouse0.93491991
146SMAD3_21741376_ChIP-Seq_HESCs_Human0.93477906
147DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92534091
148SMAD3_21741376_ChIP-Seq_ESCs_Human0.91163387
149RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90707194
150TCF4_23295773_ChIP-Seq_U87_Human0.90704089
151ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90643652
152* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89917449
153EZH2_27304074_Chip-Seq_ESCs_Mouse0.88708652
154TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88631098
155TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88556932
156NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87920211

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.30305646
2MP0000569_abnormal_digit_pigmentation3.83038263
3MP0003283_abnormal_digestive_organ3.28412426
4MP0005409_darkened_coat_color3.09081243
5MP0008057_abnormal_DNA_replication2.85603926
6MP0010234_abnormal_vibrissa_follicle2.84809799
7MP0002822_catalepsy2.83844289
8MP0003635_abnormal_synaptic_transmissio2.78703987
9MP0009780_abnormal_chondrocyte_physiolo2.69176120
10MP0004270_analgesia2.58088937
11MP0008438_abnormal_cutaneous_collagen2.40046360
12MP0003045_fibrosis2.37221469
13MP0002909_abnormal_adrenal_gland2.30110459
14MP0002063_abnormal_learning/memory/cond2.23811459
15MP0009046_muscle_twitch2.19335873
16MP0003300_gastrointestinal_ulcer2.17237705
17MP0005076_abnormal_cell_differentiation2.11051967
18MP0004233_abnormal_muscle_weight2.10546897
19MP0008961_abnormal_basal_metabolism2.03590105
20MP0009278_abnormal_bone_marrow1.87636170
21MP0002009_preneoplasia1.85675585
22MP0005451_abnormal_body_composition1.84376009
23MP0002064_seizures1.82474361
24MP0005275_abnormal_skin_tensile1.76780816
25MP0003941_abnormal_skin_development1.76647083
26MP0009745_abnormal_behavioral_response1.76245496
27MP0003191_abnormal_cellular_cholesterol1.70761311
28MP0002572_abnormal_emotion/affect_behav1.70038427
29MP0004858_abnormal_nervous_system1.69996946
30MP0003453_abnormal_keratinocyte_physiol1.68578756
31MP0010352_gastrointestinal_tract_polyps1.67733538
32MP0003705_abnormal_hypodermis_morpholog1.64994506
33MP0008569_lethality_at_weaning1.64675933
34MP0002796_impaired_skin_barrier1.63959840
35MP0001915_intracranial_hemorrhage1.62753386
36MP0004885_abnormal_endolymph1.62064761
37MP0004272_abnormal_basement_membrane1.58615246
38MP0004811_abnormal_neuron_physiology1.54625093
39MP0003172_abnormal_lysosome_physiology1.50257981
40MP0005167_abnormal_blood-brain_barrier1.48977881
41MP0002060_abnormal_skin_morphology1.44862196
42MP0000537_abnormal_urethra_morphology1.43799632
43MP0003787_abnormal_imprinting1.41791526
44MP0010678_abnormal_skin_adnexa1.39596067
45MP0004185_abnormal_adipocyte_glucose1.36698403
46MP0005623_abnormal_meninges_morphology1.36459208
47MP0001486_abnormal_startle_reflex1.35635299
48MP0003633_abnormal_nervous_system1.34331003
49MP0004130_abnormal_muscle_cell1.33175292
50MP0005621_abnormal_cell_physiology1.32100932
51MP0008260_abnormal_autophagy1.31793084
52MP0000751_myopathy1.30943028
53MP0005248_abnormal_Harderian_gland1.30078372
54MP0002734_abnormal_mechanical_nocicepti1.29784587
55MP0000003_abnormal_adipose_tissue1.28115092
56MP0003763_abnormal_thymus_physiology1.26971225
57MP0002733_abnormal_thermal_nociception1.25123583
58MP0001299_abnormal_eye_distance/1.25060319
59MP0003890_abnormal_embryonic-extraembry1.24715127
60MP0003984_embryonic_growth_retardation1.24235561
61MP0000955_abnormal_spinal_cord1.24022227
62MP0000013_abnormal_adipose_tissue1.23801830
63MP0002086_abnormal_extraembryonic_tissu1.23690919
64MP0002877_abnormal_melanocyte_morpholog1.23427345
65MP0005423_abnormal_somatic_nervous1.23207803
66MP0000778_abnormal_nervous_system1.22102772
67MP0005386_behavior/neurological_phenoty1.20877489
68MP0004924_abnormal_behavior1.20877489
69MP0002088_abnormal_embryonic_growth/wei1.19962611
70MP0002272_abnormal_nervous_system1.19129009
71MP0001849_ear_inflammation1.18875420
72MP0005023_abnormal_wound_healing1.17738007
73MP0003115_abnormal_respiratory_system1.17449041
74MP0001970_abnormal_pain_threshold1.15036511
75MP0005171_absent_coat_pigmentation1.13379951
76MP0003880_abnormal_central_pattern1.13193618
77MP0001958_emphysema1.13005173
78MP0001968_abnormal_touch/_nociception1.11410080
79MP0002166_altered_tumor_susceptibility1.11203232
80MP0002067_abnormal_sensory_capabilities1.10752833
81MP0003950_abnormal_plasma_membrane1.10445322
82MP0002396_abnormal_hematopoietic_system1.10116349
83MP0003828_pulmonary_edema1.09881576
84MP0004808_abnormal_hematopoietic_stem1.09297887
85MP0001216_abnormal_epidermal_layer1.08972984
86MP0002184_abnormal_innervation1.08938337
87MP0003091_abnormal_cell_migration1.08722462
88MP0001730_embryonic_growth_arrest1.08401288
89MP0001440_abnormal_grooming_behavior1.06696992
90MP0001672_abnormal_embryogenesis/_devel1.06172208
91MP0005380_embryogenesis_phenotype1.06172208
92MP0003868_abnormal_feces_composition1.05719574
93MP0000377_abnormal_hair_follicle1.02043253
94MP0010630_abnormal_cardiac_muscle1.01294667
95MP0001348_abnormal_lacrimal_gland1.01129827
96MP0003221_abnormal_cardiomyocyte_apopto1.00942410
97MP0006072_abnormal_retinal_apoptosis1.00304038
98MP0000767_abnormal_smooth_muscle0.99985979
99MP0003631_nervous_system_phenotype0.99411362
100MP0010368_abnormal_lymphatic_system0.99191639
101MP0002882_abnormal_neuron_morphology0.98607594
102MP0005257_abnormal_intraocular_pressure0.98053313
103MP0001501_abnormal_sleep_pattern0.96619804
104MP0003943_abnormal_hepatobiliary_system0.96429594
105MP0003123_paternal_imprinting0.94741528
106MP0002152_abnormal_brain_morphology0.94675463
107MP0005501_abnormal_skin_physiology0.94383272
108MP0003303_peritoneal_inflammation0.93610684
109MP0009672_abnormal_birth_weight0.93216532
110MP0000627_abnormal_mammary_gland0.92853137
111MP0002006_tumorigenesis0.92765289
112MP0002557_abnormal_social/conspecific_i0.92605485
113MP0003329_amyloid_beta_deposits0.91193480
114MP0002925_abnormal_cardiovascular_devel0.90975688
115MP0002066_abnormal_motor_capabilities/c0.90782376
116MP0006138_congestive_heart_failure0.90399319
117MP0000428_abnormal_craniofacial_morphol0.90362534
118MP0000858_altered_metastatic_potential0.89036479
119MP0002098_abnormal_vibrissa_morphology0.87912811
120MP0004197_abnormal_fetal_growth/weight/0.87676661
121MP0005187_abnormal_penis_morphology0.87176586
122MP0004947_skin_inflammation0.86915693
123MP0000432_abnormal_head_morphology0.86816343
124MP0003634_abnormal_glial_cell0.85976543
125MP0002089_abnormal_postnatal_growth/wei0.85873397
126MP0005375_adipose_tissue_phenotype0.85618358
127MP0000534_abnormal_ureter_morphology0.84707918
128MP0004381_abnormal_hair_follicle0.84373739
129MP0004510_myositis0.84310815
130MP0009703_decreased_birth_body0.84010616
131MP0004145_abnormal_muscle_electrophysio0.83745190
132MP0001851_eye_inflammation0.83628155
133MP0008877_abnormal_DNA_methylation0.83353272
134MP0000350_abnormal_cell_proliferation0.82802338
135MP0000733_abnormal_muscle_development0.82615601
136MP0005384_cellular_phenotype0.82614783
137MP0005645_abnormal_hypothalamus_physiol0.82460731
138MP0000383_abnormal_hair_follicle0.82336971
139MP0004087_abnormal_muscle_fiber0.80537961
140MP0003566_abnormal_cell_adhesion0.79857809
141MP0001346_abnormal_lacrimal_gland0.79534237
142MP0002108_abnormal_muscle_morphology0.79188968
143MP0003279_aneurysm0.78278219
144MP0003183_abnormal_peptide_metabolism0.77633070
145MP0010307_abnormal_tumor_latency0.77293170
146MP0003935_abnormal_craniofacial_develop0.76984640
147MP0000747_muscle_weakness0.76328132
148MP0002269_muscular_atrophy0.75868939
149MP0003075_altered_response_to0.75096030
150MP0001502_abnormal_circadian_rhythm0.74539652
151MP0002084_abnormal_developmental_patter0.72780877
152MP0005408_hypopigmentation0.72695406
153MP0004782_abnormal_surfactant_physiolog0.72587401
154MP0002896_abnormal_bone_mineralization0.72288683
155MP0002735_abnormal_chemical_nociception0.72051629
156MP0001177_atelectasis0.69603695
157MP0008874_decreased_physiological_sensi0.69141231
158MP0003879_abnormal_hair_cell0.68983673
159MP0000462_abnormal_digestive_system0.67625499
160MP0003690_abnormal_glial_cell0.66222025
161MP0003632_abnormal_nervous_system0.65390864
162MP0002168_other_aberrant_phenotype0.65142219
163MP0003861_abnormal_nervous_system0.64683487
164MP0003119_abnormal_digestive_system0.63426353
165MP0000371_diluted_coat_color0.63049064
166MP0004264_abnormal_extraembryonic_tissu0.62545017
167MP0005666_abnormal_adipose_tissue0.62219009
168MP0008770_decreased_survivor_rate0.61231386
169MP0002229_neurodegeneration0.60780052

Predicted human phenotypes

RankGene SetZ-score
1Macroorchidism (HP:0000053)3.33226883
2Action tremor (HP:0002345)3.29091663
3Arterial tortuosity (HP:0005116)3.18162172
4Flat acetabular roof (HP:0003180)3.13383599
5Cerebral aneurysm (HP:0004944)2.99213919
6Myokymia (HP:0002411)2.96859778
7Focal seizures (HP:0007359)2.90843866
8Vascular tortuosity (HP:0004948)2.86121446
9Focal motor seizures (HP:0011153)2.83744889
10Annular pancreas (HP:0001734)2.80717367
11Dysmetric saccades (HP:0000641)2.66827766
12Protrusio acetabuli (HP:0003179)2.63582278
13Abnormality of the lower motor neuron (HP:0002366)2.63127775
14Visual hallucinations (HP:0002367)2.57264241
15Asymmetry of the thorax (HP:0001555)2.54310306
16Vertebral arch anomaly (HP:0008438)2.51930582
17Osteolytic defects of the hand bones (HP:0009699)2.50132364
18Osteolytic defects of the phalanges of the hand (HP:0009771)2.50132364
19Papilledema (HP:0001085)2.45796228
20Broad face (HP:0000283)2.41359149
21Hyperacusis (HP:0010780)2.41130085
22Genetic anticipation (HP:0003743)2.38747205
23Abnormality of the distal phalanx of the thumb (HP:0009617)2.37661234
24Heterotopia (HP:0002282)2.36887617
25Aqueductal stenosis (HP:0002410)2.36717811
26Urinary bladder sphincter dysfunction (HP:0002839)2.36009160
27Right ventricular cardiomyopathy (HP:0011663)2.28405992
28Dysdiadochokinesis (HP:0002075)2.27804692
29Termporal pattern (HP:0011008)2.27332527
30Insidious onset (HP:0003587)2.27332527
31Overgrowth (HP:0001548)2.24212190
32Turricephaly (HP:0000262)2.24050262
33Atonic seizures (HP:0010819)2.19358692
34Febrile seizures (HP:0002373)2.19342247
35Impaired smooth pursuit (HP:0007772)2.18281437
36Volvulus (HP:0002580)2.17797058
37Progressive cerebellar ataxia (HP:0002073)2.15891332
38Urinary urgency (HP:0000012)2.15175917
39Dislocated radial head (HP:0003083)2.13922391
40Pointed chin (HP:0000307)2.13638160
41Abnormality of the astrocytes (HP:0100707)2.13160130
42Astrocytoma (HP:0009592)2.13160130
43Ankyloglossia (HP:0010296)2.12493755
44Deep philtrum (HP:0002002)2.11411785
45Impaired vibration sensation in the lower limbs (HP:0002166)2.11162944
46Syringomyelia (HP:0003396)2.10394168
47Spinal cord lesions (HP:0100561)2.10394168
48Sparse lateral eyebrow (HP:0005338)2.10368693
49Intention tremor (HP:0002080)2.10206065
50Postural instability (HP:0002172)2.06135567
51Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.05201769
52Cubitus valgus (HP:0002967)2.04912760
53Absence seizures (HP:0002121)2.04493018
54Hemiplegia (HP:0002301)2.02278287
55Ankle clonus (HP:0011448)2.01082920
56Upper limb amyotrophy (HP:0009129)2.00894312
57Distal upper limb amyotrophy (HP:0007149)2.00894312
58Supranuclear gaze palsy (HP:0000605)2.00879610
59Elfin facies (HP:0004428)2.00551536
60Narrow palate (HP:0000189)1.99983129
61Epileptic encephalopathy (HP:0200134)1.99571126
62Abnormality of ocular smooth pursuit (HP:0000617)1.98062435
63Hypercortisolism (HP:0001578)1.97807010
64Resting tremor (HP:0002322)1.97212279
65Aortic dissection (HP:0002647)1.97148114
66Premature rupture of membranes (HP:0001788)1.97071544
67Gaze-evoked nystagmus (HP:0000640)1.97040775
68Wormian bones (HP:0002645)1.96038058
69Impaired social interactions (HP:0000735)1.94445295
70Abnormal social behavior (HP:0012433)1.94445295
71Insomnia (HP:0100785)1.93953656
72Subacute progressive viral hepatitis (HP:0006572)1.93144811
73Abnormality of the radial head (HP:0003995)1.93054414
74Germ cell neoplasia (HP:0100728)1.93050027
75Truncal ataxia (HP:0002078)1.92187553
76Advanced eruption of teeth (HP:0006288)1.90695315
77Neoplasm of the heart (HP:0100544)1.90195991
78Coarse hair (HP:0002208)1.89602425
79Mitral stenosis (HP:0001718)1.88738270
80Hand muscle atrophy (HP:0009130)1.88605559
81Depression (HP:0000716)1.87609780
82Long eyelashes (HP:0000527)1.85784567
83Dysmetria (HP:0001310)1.83070896
84Atrophic scars (HP:0001075)1.81415793
85Obsessive-compulsive behavior (HP:0000722)1.81139465
86Ulnar bowing (HP:0003031)1.81061068
87Bundle branch block (HP:0011710)1.80541881
88Abnormal foot bone ossification (HP:0010675)1.80454507
89Cervical subluxation (HP:0003308)1.79565508
90Shallow orbits (HP:0000586)1.79390394
91Male infertility (HP:0003251)1.78632163
92Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.77478653
93Abnormality of oral frenula (HP:0000190)1.77291875
94Increased CSF protein (HP:0002922)1.74785781
95Cerebral inclusion bodies (HP:0100314)1.74360684
96Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.73590717
97Poor eye contact (HP:0000817)1.73352807
98Bladder carcinoma (HP:0002862)1.73115739
99Bladder neoplasm (HP:0009725)1.73115739
100Truncal obesity (HP:0001956)1.72784587
101Aneurysm (HP:0002617)1.71913002
102Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.71302482
103Abnormality of the fingertips (HP:0001211)1.71272013
104Menstrual irregularities (HP:0000858)1.71008045
105Dilatation of the ascending aorta (HP:0005111)1.70805786
106Curly hair (HP:0002212)1.70011404
107Thin bony cortex (HP:0002753)1.69816053
108Relative macrocephaly (HP:0004482)1.69564554
109Uterine leiomyosarcoma (HP:0002891)1.69332991
110Leiomyosarcoma (HP:0100243)1.69332991
111Persistence of primary teeth (HP:0006335)1.69219870
112Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.68586244
113Difficulty running (HP:0009046)1.67314300
114Abnormal ossification of hand bones (HP:0005921)1.66957929
115Buphthalmos (HP:0000557)1.66562245
116Abnormality of carpal bone ossification (HP:0006257)1.66516231
117Aortic aneurysm (HP:0004942)1.66176477
118Abnormality of the nasal septum (HP:0000419)1.65148619
119Thyroid carcinoma (HP:0002890)1.64848016
120Distal lower limb amyotrophy (HP:0008944)1.64348409
121Broad-based gait (HP:0002136)1.63556809
122Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.62068518
123Dialeptic seizures (HP:0011146)1.61025257
124Enlarged penis (HP:0000040)1.60732325
125Short nail (HP:0001799)1.58974830
126Lower limb amyotrophy (HP:0007210)1.58892356
127Missing ribs (HP:0000921)1.58847202
128Short chin (HP:0000331)1.58773239
129Sandal gap (HP:0001852)1.58461705
130Periodontitis (HP:0000704)1.58080933
131Joint laxity (HP:0001388)1.56515553
132Renovascular hypertension (HP:0100817)1.56006494
133Gastrointestinal carcinoma (HP:0002672)1.55783729
134Malignant gastrointestinal tract tumors (HP:0006749)1.55783729
135Frequent falls (HP:0002359)1.55752557
136Generalized tonic-clonic seizures (HP:0002069)1.55517470
137Thickened calvaria (HP:0002684)1.55069240
138Testicular neoplasm (HP:0010788)1.54982862
139Scanning speech (HP:0002168)1.54797502
140Congenital glaucoma (HP:0001087)1.54731416
141Absent frontal sinuses (HP:0002688)1.54718398
142Hyporeflexia of lower limbs (HP:0002600)1.54424827
143Limited elbow extension (HP:0001377)1.53559532
144Deviation of the thumb (HP:0009603)1.52943815
145Stereotypic behavior (HP:0000733)1.52767318
146Abnormality of the left ventricular outflow tract (HP:0011103)1.52592865
147Subaortic stenosis (HP:0001682)1.52592865
148Abnormality of the periventricular white matter (HP:0002518)1.52558076
149Broad palm (HP:0001169)1.52306943
150Bowel diverticulosis (HP:0005222)1.52280125
151Striae distensae (HP:0001065)1.52263850
152Excessive salivation (HP:0003781)1.52073915
153Drooling (HP:0002307)1.52073915
154Congenital hip dislocation (HP:0001374)1.51909812
155Abnormality of the epiphyses of the hand (HP:0005924)1.51780998
156Inappropriate behavior (HP:0000719)1.51634949
157Ventricular fibrillation (HP:0001663)1.51267993
158Open mouth (HP:0000194)1.50962852
159Overriding aorta (HP:0002623)1.50291098
160Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.50119878
161Transitional cell carcinoma of the bladder (HP:0006740)1.50065478
162Papillary thyroid carcinoma (HP:0002895)1.49777974
163Mitral valve prolapse (HP:0001634)1.49512758
164Renal cell carcinoma (HP:0005584)1.49275399
165Urethral obstruction (HP:0000796)1.48798408
166Anteriorly placed anus (HP:0001545)1.48766973
167Low anterior hairline (HP:0000294)1.47436207
168Natal tooth (HP:0000695)1.47042556
169Lip pit (HP:0100267)1.46899483
170Abnormality of the humeroradial joint (HP:0100744)1.46718599
171Deep venous thrombosis (HP:0002625)1.45608019
172Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.45358282
173Obstructive sleep apnea (HP:0002870)1.44647517
174Disproportionate tall stature (HP:0001519)1.44255401
175Cranial hyperostosis (HP:0004437)1.44109982

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.30728955
2ICK2.67044132
3AKT32.43415847
4TYRO32.42079549
5NTRK32.41092764
6BRD42.39714102
7FGFR42.35468188
8RIPK12.33347965
9DDR22.14539992
10PRKD32.01568426
11MAP3K41.98840552
12CAMK1G1.95631555
13TRIB31.93878318
14PRPF4B1.93841431
15PDGFRA1.90832351
16KSR21.85924061
17EPHA41.76710070
18PAK61.71059783
19CAMK1D1.65173641
20CAMKK11.63698660
21MAP3K21.63307524
22MAP3K61.60053714
23CDK121.57760933
24SMG11.51946336
25SIK21.49016270
26MET1.48792192
27STK381.47599025
28NEK91.47342321
29LATS11.42213303
30DMPK1.37395111
31DAPK21.37164530
32MARK11.33613087
33NTRK21.33443660
34BMX1.32898569
35EPHB11.29641448
36SCYL21.27470113
37PKN21.23314562
38SGK31.22889717
39EPHA21.22763273
40RET1.22354401
41NTRK11.21492288
42YES11.20560005
43FGR1.15042994
44FGFR21.14391650
45UHMK11.13943610
46MINK11.12943914
47TAOK11.12675925
48ERN11.12327866
49PDGFRB1.11865373
50PRKD21.10918001
51PRKCH1.10260440
52CDC42BPA1.10217362
53DAPK11.09442434
54WNK11.08582843
55ALK1.08538217
56PHKG11.08532860
57PHKG21.08532860
58EEF2K1.06502259
59FRK1.01836105
60RIPK41.01789919
61LMTK20.97581360
62TTN0.96383356
63CDK50.95613855
64KSR10.94386588
65LATS20.93390156
66STK110.91811059
67NLK0.91104893
68MARK20.90873580
69MAP2K40.89558539
70MELK0.89310909
71CDK60.88865249
72MAP3K70.87669987
73SGK10.87327457
74PTK60.86415437
75CAMKK20.83899116
76MTOR0.82746620
77PTK20.80975184
78NEK60.80414265
79MAP3K100.79996175
80HIPK20.77941520
81MAP3K140.77681855
82FGFR30.76150128
83SIK10.72958639
84FGFR10.72955022
85SGK20.72748477
86CSK0.72488554
87PRKAA10.70641935
88DYRK1B0.70234283
89PINK10.68931290
90MAP3K130.67522167
91PDK10.65721335
92PAK30.60441617
93MAPK100.59605664
94CDK90.58211226
95MAPK110.57503681
96PDPK10.56783813
97CDK40.56762678
98SGK4940.55319051
99SGK2230.55319051
100RPS6KA30.55240672
101JAK10.53168071
102MST1R0.53106537
103BMPR20.52129013
104PRKAA20.50576719
105ZAP700.50364216
106MATK0.50073582
107MAP3K10.49786350
108PAK40.49226767
109EPHA30.48452387
110FER0.48098994
111FYN0.47415712
112PRKD10.46954003
113RPS6KB10.46584364
114STK30.45909282
115MAP2K30.45055752
116ERBB40.43943545
117PAK20.43861115
118PNCK0.43269218
119STK38L0.41798567
120MAPK150.41519461
121MAP3K30.41284867
122EGFR0.41155290
123BCR0.40712751
124STK240.40709938
125RAF10.40580682
126RPS6KB20.39623337
127CDK70.39224036
128JAK20.39094452
129FES0.38870219
130RPS6KA20.38095102
131TYK20.37784658
132NEK10.37606226
133CAMK40.37410985
134PTK2B0.36710518
135TRPM70.35772460
136ERBB20.35002693
137CHEK10.33710040
138GSK3B0.33586893

Predicted pathways (KEGG)

RankGene SetZ-score
1Thyroid cancer_Homo sapiens_hsa052161.97646652
2Long-term potentiation_Homo sapiens_hsa047201.83974769
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.75980296
4Olfactory transduction_Homo sapiens_hsa047401.75668170
5mTOR signaling pathway_Homo sapiens_hsa041501.66382414
6Prostate cancer_Homo sapiens_hsa052151.63104795
7Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.63093427
8Circadian entrainment_Homo sapiens_hsa047131.61999325
9Dorso-ventral axis formation_Homo sapiens_hsa043201.59454624
10Type II diabetes mellitus_Homo sapiens_hsa049301.55929875
11Salivary secretion_Homo sapiens_hsa049701.54375501
12Synaptic vesicle cycle_Homo sapiens_hsa047211.52493855
13Gastric acid secretion_Homo sapiens_hsa049711.50523898
14Glutamatergic synapse_Homo sapiens_hsa047241.50212459
15Acute myeloid leukemia_Homo sapiens_hsa052211.49481347
16Nicotine addiction_Homo sapiens_hsa050331.49114584
17Small cell lung cancer_Homo sapiens_hsa052221.47690791
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47512471
19GABAergic synapse_Homo sapiens_hsa047271.45951438
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45061386
21Morphine addiction_Homo sapiens_hsa050321.43775133
22Insulin secretion_Homo sapiens_hsa049111.43665537
23Dopaminergic synapse_Homo sapiens_hsa047281.41710687
24Fatty acid biosynthesis_Homo sapiens_hsa000611.39739249
25Amphetamine addiction_Homo sapiens_hsa050311.38667530
26GnRH signaling pathway_Homo sapiens_hsa049121.38097667
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.37870396
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36649846
29Glioma_Homo sapiens_hsa052141.35557905
30Cholinergic synapse_Homo sapiens_hsa047251.35035633
31Renin secretion_Homo sapiens_hsa049241.34593749
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34301727
33Estrogen signaling pathway_Homo sapiens_hsa049151.31520187
34Oxytocin signaling pathway_Homo sapiens_hsa049211.29352078
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24997936
36Gap junction_Homo sapiens_hsa045401.22051952
37ErbB signaling pathway_Homo sapiens_hsa040121.20212377
38Long-term depression_Homo sapiens_hsa047301.18561529
39VEGF signaling pathway_Homo sapiens_hsa043701.16166627
40Notch signaling pathway_Homo sapiens_hsa043301.15747185
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13378395
42FoxO signaling pathway_Homo sapiens_hsa040681.12892155
43Endometrial cancer_Homo sapiens_hsa052131.12585566
44Longevity regulating pathway - mammal_Homo sapiens_hsa042111.10547470
45Bladder cancer_Homo sapiens_hsa052191.10494799
46Adherens junction_Homo sapiens_hsa045201.10441628
47ECM-receptor interaction_Homo sapiens_hsa045121.09593922
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08551306
49Nitrogen metabolism_Homo sapiens_hsa009101.08338993
50Amoebiasis_Homo sapiens_hsa051461.06624118
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04903170
52Hepatitis B_Homo sapiens_hsa051611.04200153
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.03940891
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03664614
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02601811
56cAMP signaling pathway_Homo sapiens_hsa040241.02323468
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02046648
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00195530
59Choline metabolism in cancer_Homo sapiens_hsa052311.00098798
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99941106
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.98918528
62Chronic myeloid leukemia_Homo sapiens_hsa052200.98595826
63Cocaine addiction_Homo sapiens_hsa050300.94076056
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.93194815
65Circadian rhythm_Homo sapiens_hsa047100.90597963
66Non-small cell lung cancer_Homo sapiens_hsa052230.90530718
67Dilated cardiomyopathy_Homo sapiens_hsa054140.89577009
68Colorectal cancer_Homo sapiens_hsa052100.89293494
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89029956
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88450103
71Calcium signaling pathway_Homo sapiens_hsa040200.88230486
72MAPK signaling pathway_Homo sapiens_hsa040100.87701732
73Hepatitis C_Homo sapiens_hsa051600.87430511
74Pancreatic secretion_Homo sapiens_hsa049720.87185350
75Proteoglycans in cancer_Homo sapiens_hsa052050.86813441
76T cell receptor signaling pathway_Homo sapiens_hsa046600.85844031
77Insulin signaling pathway_Homo sapiens_hsa049100.85687916
78Melanogenesis_Homo sapiens_hsa049160.85112623
79Focal adhesion_Homo sapiens_hsa045100.83984773
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83593362
81Axon guidance_Homo sapiens_hsa043600.83476478
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83314857
83Oocyte meiosis_Homo sapiens_hsa041140.82261908
84Thyroid hormone synthesis_Homo sapiens_hsa049180.82220476
85Endocytosis_Homo sapiens_hsa041440.80565555
86Inositol phosphate metabolism_Homo sapiens_hsa005620.80526055
87Pathways in cancer_Homo sapiens_hsa052000.79999170
88Rap1 signaling pathway_Homo sapiens_hsa040150.79597364
89Renal cell carcinoma_Homo sapiens_hsa052110.79085281
90Taste transduction_Homo sapiens_hsa047420.77502773
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77007508
92HIF-1 signaling pathway_Homo sapiens_hsa040660.76999455
93Pancreatic cancer_Homo sapiens_hsa052120.75946433
94Hippo signaling pathway_Homo sapiens_hsa043900.75333364
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.74494428
96Lysine degradation_Homo sapiens_hsa003100.74297135
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.73222031
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72257648
99AMPK signaling pathway_Homo sapiens_hsa041520.71419589
100Insulin resistance_Homo sapiens_hsa049310.70939318
101Glucagon signaling pathway_Homo sapiens_hsa049220.70718467
102Tight junction_Homo sapiens_hsa045300.70672646
103Melanoma_Homo sapiens_hsa052180.70288461
104Viral carcinogenesis_Homo sapiens_hsa052030.70282087
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.70257799
106Wnt signaling pathway_Homo sapiens_hsa043100.69965302
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.69639160
108Platelet activation_Homo sapiens_hsa046110.69496183
109Toxoplasmosis_Homo sapiens_hsa051450.68494709
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68275395
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67619116
112TNF signaling pathway_Homo sapiens_hsa046680.66805640
113Prolactin signaling pathway_Homo sapiens_hsa049170.66581181
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65928295
115Osteoclast differentiation_Homo sapiens_hsa043800.65430376
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65194275
117Chemokine signaling pathway_Homo sapiens_hsa040620.65161080
118Measles_Homo sapiens_hsa051620.65084741
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64903032
120Prion diseases_Homo sapiens_hsa050200.64800753
121MicroRNAs in cancer_Homo sapiens_hsa052060.64697490
122Hedgehog signaling pathway_Homo sapiens_hsa043400.64346788
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64180489
124Serotonergic synapse_Homo sapiens_hsa047260.62955754
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62353034
126Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61332862
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61277923
128mRNA surveillance pathway_Homo sapiens_hsa030150.60853508
129B cell receptor signaling pathway_Homo sapiens_hsa046620.59807323
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59330443
131Apoptosis_Homo sapiens_hsa042100.59219004
132TGF-beta signaling pathway_Homo sapiens_hsa043500.58828706
133Influenza A_Homo sapiens_hsa051640.57700585
134Ras signaling pathway_Homo sapiens_hsa040140.56753116
135Other glycan degradation_Homo sapiens_hsa005110.55621223
136Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55132062
137Jak-STAT signaling pathway_Homo sapiens_hsa046300.54485796

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