RALGDS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.52801235
2negative regulation of erythrocyte differentiation (GO:0045647)4.45045418
3central nervous system myelination (GO:0022010)4.23240007
4axon ensheathment in central nervous system (GO:0032291)4.23240007
5regulation of ARF protein signal transduction (GO:0032012)3.92664733
6regulation of response to osmotic stress (GO:0047484)3.42126027
7proline transport (GO:0015824)3.41319107
8nerve growth factor signaling pathway (GO:0038180)3.40972893
9positive regulation of macrophage cytokine production (GO:0060907)3.34116261
10synaptic vesicle docking involved in exocytosis (GO:0016081)3.33234713
11positive regulation of Rap GTPase activity (GO:0032854)3.29272610
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.25136993
13microtubule severing (GO:0051013)3.19717493
14layer formation in cerebral cortex (GO:0021819)3.18676257
15response to nerve growth factor (GO:1990089)3.17067910
16cellular response to nerve growth factor stimulus (GO:1990090)3.17067910
17maintenance of protein location in nucleus (GO:0051457)3.13150348
18negative regulation of cell killing (GO:0031342)3.12634465
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.12634465
20negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.10588726
21detection of temperature stimulus (GO:0016048)3.06883687
22response to muramyl dipeptide (GO:0032495)3.05264228
23axon ensheathment (GO:0008366)3.03163014
24ensheathment of neurons (GO:0007272)3.03163014
25mannose metabolic process (GO:0006013)3.01548863
26regulation of cilium movement (GO:0003352)2.99828626
27positive regulation of gamma-delta T cell activation (GO:0046645)2.95759314
28regulation of microtubule-based movement (GO:0060632)2.94339112
29myelination (GO:0042552)2.94282395
30myelin maintenance (GO:0043217)2.89359633
31positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.88021876
32locomotory exploration behavior (GO:0035641)2.87799333
33peptidyl-tyrosine autophosphorylation (GO:0038083)2.87133373
34cytoskeletal anchoring at plasma membrane (GO:0007016)2.86034248
35signal complex assembly (GO:0007172)2.83298697
36response to dietary excess (GO:0002021)2.82711755
37sodium ion export (GO:0071436)2.79673365
38positive thymic T cell selection (GO:0045059)2.75694202
39negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.75644178
40regulation of short-term neuronal synaptic plasticity (GO:0048172)2.75385006
41cell migration in hindbrain (GO:0021535)2.74220524
42germinal center formation (GO:0002467)2.72931842
43L-amino acid import (GO:0043092)2.72893713
44cerebellar granule cell differentiation (GO:0021707)2.72081296
45ventricular system development (GO:0021591)2.71259298
46protein localization to endosome (GO:0036010)2.69463210
47positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.69068784
48negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.68749119
49activation of MAPKKK activity (GO:0000185)2.68665407
50dendrite morphogenesis (GO:0048813)2.65745894
51fusion of sperm to egg plasma membrane (GO:0007342)2.64704584
52cellular potassium ion homeostasis (GO:0030007)2.63839414
53synaptic vesicle exocytosis (GO:0016079)2.59888745
54antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.58346985
55thymic T cell selection (GO:0045061)2.54110581
56glutamate secretion (GO:0014047)2.54070581
57dendritic spine morphogenesis (GO:0060997)2.52072323
58regulation of NFAT protein import into nucleus (GO:0051532)2.49446922
59negative regulation of potassium ion transmembrane transport (GO:1901380)2.48600253
60regulation of synaptic vesicle exocytosis (GO:2000300)2.48192821
61positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.47571881
62regulation of macrophage cytokine production (GO:0010935)2.45508876
63regulation of gamma-delta T cell activation (GO:0046643)2.45105865
64protein polyglutamylation (GO:0018095)2.44825234
65epithelial cell differentiation involved in prostate gland development (GO:0060742)2.44307630
66doxorubicin metabolic process (GO:0044598)2.44092718
67daunorubicin metabolic process (GO:0044597)2.44092718
68polyketide metabolic process (GO:0030638)2.44092718
69phosphatidylinositol 3-kinase signaling (GO:0014065)2.42515580
70antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.41918484
71negative regulation of inclusion body assembly (GO:0090084)2.41650670
72glycine transport (GO:0015816)2.41259669
73regulation of T-helper 2 cell differentiation (GO:0045628)2.40080065
74oligodendrocyte differentiation (GO:0048709)2.39471438
75G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.38710541
76positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.37327829
77regulation of autophagic vacuole assembly (GO:2000785)2.36206889
78regulation of synapse structural plasticity (GO:0051823)2.35147565
79positive regulation of cellular amide metabolic process (GO:0034250)2.34587967
80branching involved in labyrinthine layer morphogenesis (GO:0060670)2.34399592
81negative regulation of axonogenesis (GO:0050771)2.34365176
82regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.34055428
83negative regulation of toll-like receptor signaling pathway (GO:0034122)2.32984124
84antigen processing and presentation of endogenous antigen (GO:0019883)2.32081018
85response to peptidoglycan (GO:0032494)2.31451910
86cell-cell junction maintenance (GO:0045217)2.29907446
87establishment of mitochondrion localization (GO:0051654)2.29431724
88neuromuscular process controlling balance (GO:0050885)2.28293200
89regulation of synaptic vesicle transport (GO:1902803)2.27731569
90axonal fasciculation (GO:0007413)2.27688903
91ovulation cycle (GO:0042698)2.26553098
92ionotropic glutamate receptor signaling pathway (GO:0035235)2.26482050
93macrophage activation involved in immune response (GO:0002281)2.26349552
94cerebral cortex neuron differentiation (GO:0021895)2.26274424
95cellular response to monoamine stimulus (GO:0071868)2.26199112
96cellular response to catecholamine stimulus (GO:0071870)2.26199112
97regulation of gamma-delta T cell differentiation (GO:0045586)2.25508174
98apical protein localization (GO:0045176)2.25455059
99clathrin coat assembly (GO:0048268)2.25386914
100amino acid import (GO:0043090)2.25371330
101acrosome reaction (GO:0007340)2.25313815
102regulation of ARF GTPase activity (GO:0032312)2.25151387
103plasma membrane fusion (GO:0045026)2.24801642
104activation of protein kinase A activity (GO:0034199)2.23772968
105virion attachment to host cell (GO:0019062)2.23646954
106adhesion of symbiont to host cell (GO:0044650)2.23646954
107detection of temperature stimulus involved in sensory perception (GO:0050961)2.23485776
108detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.23485776
109activation of JUN kinase activity (GO:0007257)2.23425490
110response to laminar fluid shear stress (GO:0034616)2.23069134
111barbed-end actin filament capping (GO:0051016)2.22563871
112Golgi to endosome transport (GO:0006895)2.22461113
113semaphorin-plexin signaling pathway (GO:0071526)2.21627195
114positive T cell selection (GO:0043368)2.20737786
115positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.20595396
116antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.20397779
117detection of other organism (GO:0098543)2.19988221
118Rap protein signal transduction (GO:0032486)2.18969128
119positive regulation of histone deacetylation (GO:0031065)2.18442665
120positive regulation of receptor recycling (GO:0001921)2.18096960
121neuron recognition (GO:0008038)2.18078724
122neuron cell-cell adhesion (GO:0007158)2.17321878
123T cell selection (GO:0045058)2.17185622
124response to auditory stimulus (GO:0010996)2.17164162
125detection of bacterium (GO:0016045)2.16943382
126calcium-mediated signaling using intracellular calcium source (GO:0035584)2.15942490
127adenosine receptor signaling pathway (GO:0001973)2.15812691
128somite rostral/caudal axis specification (GO:0032525)2.14531573
129regulation of early endosome to late endosome transport (GO:2000641)2.14368417
130regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.14185065
131potassium ion import (GO:0010107)2.13926106
132dopamine receptor signaling pathway (GO:0007212)2.13647524
133regulation of neuronal synaptic plasticity (GO:0048168)2.12076985
134negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.11408514
135vocalization behavior (GO:0071625)2.10967162
136adult walking behavior (GO:0007628)2.10623163
137tolerance induction (GO:0002507)2.09933574
138potassium ion homeostasis (GO:0055075)2.09828381
139neuronal ion channel clustering (GO:0045161)2.09788020
140synaptic transmission, glutamatergic (GO:0035249)2.09689717
141asymmetric protein localization (GO:0008105)2.09656681
142endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.09415706
143NIK/NF-kappaB signaling (GO:0038061)2.09367617
144lipopolysaccharide-mediated signaling pathway (GO:0031663)2.08830239
145response to lipoprotein particle (GO:0055094)2.08660554
146mating behavior (GO:0007617)2.08500414
147negative regulation of myotube differentiation (GO:0010832)2.08376011
148endothelial cell chemotaxis (GO:0035767)2.07867242
149cell volume homeostasis (GO:0006884)2.07718969
150positive regulation of synapse maturation (GO:0090129)2.07140289
151protein targeting to Golgi (GO:0000042)2.07108638
152negative regulation of neurotransmitter secretion (GO:0046929)2.06857024
153vesicle transport along microtubule (GO:0047496)2.06204352
154macroautophagy (GO:0016236)2.06015343
155negative regulation of catenin import into nucleus (GO:0035414)2.05176739
156regulation of Rap GTPase activity (GO:0032317)2.05120788
157positive regulation of protein dephosphorylation (GO:0035307)2.04552547
158regulation of leukocyte degranulation (GO:0043300)2.04155472
159cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.01509400
160neurotransmitter secretion (GO:0007269)2.00252267
161cerebellar Purkinje cell differentiation (GO:0021702)1.98305536
162negative regulation of Ras protein signal transduction (GO:0046580)1.97798304
163leukocyte aggregation (GO:0070486)1.96902997
164negative thymic T cell selection (GO:0045060)1.96834481
165modulation by symbiont of host cellular process (GO:0044068)1.96665246
166negative regulation of leukocyte mediated immunity (GO:0002704)1.96527973
167regulation of synaptic plasticity (GO:0048167)1.96469624

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.03071897
2BP1_19119308_ChIP-ChIP_Hs578T_Human2.95080806
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.72878977
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.72878977
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.72878977
6VDR_21846776_ChIP-Seq_THP-1_Human2.32678009
7* TCF7_22412390_ChIP-Seq_EML_Mouse2.23929260
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14513833
9* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.12274659
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.02708533
11* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.96026077
12RNF2_18974828_ChIP-Seq_MESCs_Mouse1.94381542
13EZH2_18974828_ChIP-Seq_MESCs_Mouse1.94381542
14ELK3_25401928_ChIP-Seq_HUVEC_Human1.93133045
15TP63_17297297_ChIP-ChIP_HaCaT_Human1.90508265
16MYC_22102868_ChIP-Seq_BL_Human1.88229599
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86101809
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81939495
19RNF2_27304074_Chip-Seq_ESCs_Mouse1.81051516
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.79312669
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.79232558
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78540930
23* RARB_27405468_Chip-Seq_BRAIN_Mouse1.78313052
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77850719
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77795777
26* KDM2B_26808549_Chip-Seq_K562_Human1.76265496
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73429560
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72041724
29* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70909780
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.68125081
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.67818134
32DROSHA_22980978_ChIP-Seq_HELA_Human1.65152064
33* RACK7_27058665_Chip-Seq_MCF-7_Human1.64937574
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63406980
35* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63131264
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62401841
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61974752
38VDR_24763502_ChIP-Seq_THP-1_Human1.61634675
39REST_21632747_ChIP-Seq_MESCs_Mouse1.59367860
40* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.57126191
41* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54209384
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52282270
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50697053
44ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50681134
45* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48695923
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45169062
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.43669872
48* ESR2_21235772_ChIP-Seq_MCF-7_Human1.43095858
49SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40858548
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.39182768
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.38988327
52RING1B_27294783_Chip-Seq_NPCs_Mouse1.38912275
53MAF_26560356_Chip-Seq_TH1_Human1.36681408
54SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35422331
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35021435
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34970970
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.34303026
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33684374
59CREB1_26743006_Chip-Seq_LNCaP_Human1.33397850
60* P68_20966046_ChIP-Seq_HELA_Human1.32577751
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31878502
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.30968470
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.30785350
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28299999
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27227000
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27113243
67* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26078199
68SCL_19346495_ChIP-Seq_HPC-7_Human1.25835871
69NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.24706752
70MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24291171
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23863290
72SPI1_23127762_ChIP-Seq_K562_Human1.23323821
73* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21591068
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.21495317
75NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21128505
76UTX_26944678_Chip-Seq_JUKART_Human1.21067667
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20957914
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.20485899
79AHR_22903824_ChIP-Seq_MCF-7_Human1.19510493
80CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18802022
81NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18000774
82SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.16966627
83MAF_26560356_Chip-Seq_TH2_Human1.16463754
84GATA1_19941826_ChIP-Seq_K562_Human1.15602451
85* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15261285
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15212358
87* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14947164
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11997036
89RUNX1_27514584_Chip-Seq_MCF-7_Human1.11917867
90NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.11814479
91IRF8_22096565_ChIP-ChIP_GC-B_Human1.10963624
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10762811
93GATA1_26923725_Chip-Seq_HPCs_Mouse1.09977219
94RUNX_20019798_ChIP-Seq_JUKART_Human1.09821483
95BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08170436
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07546909
97* FOXO3_23340844_ChIP-Seq_DLD1_Human1.06858796
98SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06286625
99KDM2B_26808549_Chip-Seq_DND41_Human1.06015326
100EED_16625203_ChIP-ChIP_MESCs_Mouse1.05831218
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05812281
102ELK4_26923725_Chip-Seq_MESODERM_Mouse1.05086022
103GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04471054
104DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03509564
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03135214
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03107230
107* KLF5_25053715_ChIP-Seq_YYC3_Human1.02791328
108LXR_22292898_ChIP-Seq_THP-1_Human1.02736111
109SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02253765
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.02222653
111ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01507262
112* IRF8_27001747_Chip-Seq_BMDM_Mouse1.01204340
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00533413
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00263166
115TET1_21451524_ChIP-Seq_MESCs_Mouse1.00244909
116TET1_21490601_ChIP-Seq_MESCs_Mouse0.99472699
117* BCOR_27268052_Chip-Seq_Bcells_Human0.99157453
118CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98491632
119TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98470837
120CLOCK_20551151_ChIP-Seq_293T_Human0.97742207
121SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97694443
122TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97072283
123* SMC4_20622854_ChIP-Seq_HELA_Human0.96874770
124PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.96596719
125MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96322865
126STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95628018
127NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95418696
128NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94335776
129THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94215584
130SMAD3_21741376_ChIP-Seq_HESCs_Human0.94055407
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93961026
132ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92070321
133P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86538043
134CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86046085
135RNF2_27304074_Chip-Seq_NSC_Mouse0.85791772
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85232457
137* OCT4_19829295_ChIP-Seq_ESCs_Human0.82484222
138* KDM2B_26808549_Chip-Seq_JURKAT_Human0.82357859
139TP53_22127205_ChIP-Seq_IMR90_Human0.82134882
140CDX2_20551321_ChIP-Seq_CACO-2_Human0.81449513
141TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.81305313
142GBX2_23144817_ChIP-Seq_PC3_Human0.81163802
143* TP63_22573176_ChIP-Seq_HFKS_Human0.80455898
144CTCF_27219007_Chip-Seq_Bcells_Human0.79822393
145* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79785395
146TP53_20018659_ChIP-ChIP_R1E_Mouse0.79307888
147* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79209083
148AR_19668381_ChIP-Seq_PC3_Human0.79069828
149NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.79016832
150P53_22127205_ChIP-Seq_FIBROBLAST_Human0.79000473
151ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78671704
152SMAD4_21741376_ChIP-Seq_HESCs_Human0.78356018
153HIF1A_21447827_ChIP-Seq_MCF-7_Human0.77917063
154ESR1_20079471_ChIP-ChIP_T-47D_Human0.77802280

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004858_abnormal_nervous_system4.28330613
2MP0004859_abnormal_synaptic_plasticity3.81358749
3MP0004270_analgesia3.12647529
4MP0005410_abnormal_fertilization2.95630217
5MP0003436_decreased_susceptibility_to2.64716506
6MP0002254_reproductive_system_inflammat2.60637584
7MP0000920_abnormal_myelination2.44860559
8MP0005058_abnormal_lysosome_morphology2.36051012
9MP0003635_abnormal_synaptic_transmissio2.20955449
10MP0002653_abnormal_ependyma_morphology2.20667199
11MP0009278_abnormal_bone_marrow2.19307491
12MP0003300_gastrointestinal_ulcer2.17378828
13MP0003880_abnormal_central_pattern2.10784549
14MP0009046_muscle_twitch2.05611333
15MP0005394_taste/olfaction_phenotype1.99463239
16MP0005499_abnormal_olfactory_system1.99463239
17MP0004947_skin_inflammation1.96305119
18MP0003329_amyloid_beta_deposits1.93775294
19MP0000778_abnormal_nervous_system1.91586339
20MP0002064_seizures1.90118663
21MP0004885_abnormal_endolymph1.87373300
22MP0003634_abnormal_glial_cell1.84772157
23MP0005409_darkened_coat_color1.83796815
24MP0003183_abnormal_peptide_metabolism1.81963395
25MP0001486_abnormal_startle_reflex1.81653751
26MP0002734_abnormal_mechanical_nocicepti1.81141900
27MP0003690_abnormal_glial_cell1.81036695
28MP0003705_abnormal_hypodermis_morpholog1.76536789
29MP0002063_abnormal_learning/memory/cond1.75556236
30MP0005623_abnormal_meninges_morphology1.74832612
31MP0003122_maternal_imprinting1.74723885
32MP0003724_increased_susceptibility_to1.71540334
33MP0004264_abnormal_extraembryonic_tissu1.68215622
34MP0000955_abnormal_spinal_cord1.68072688
35MP0009840_abnormal_foam_cell1.66658658
36MP0008961_abnormal_basal_metabolism1.60261833
37MP0005000_abnormal_immune_tolerance1.59605450
38MP0008260_abnormal_autophagy1.57859446
39MP0003879_abnormal_hair_cell1.56033353
40MP0001849_ear_inflammation1.55500389
41MP0002272_abnormal_nervous_system1.55110297
42MP0003011_delayed_dark_adaptation1.54891996
43MP0003191_abnormal_cellular_cholesterol1.53949696
44MP0002572_abnormal_emotion/affect_behav1.52645387
45MP0009745_abnormal_behavioral_response1.51306327
46MP0005025_abnormal_response_to1.48894676
47MP0003763_abnormal_thymus_physiology1.48609303
48MP0002419_abnormal_innate_immunity1.48092741
49MP0001790_abnormal_immune_system1.47697066
50MP0005387_immune_system_phenotype1.47697066
51MP0002733_abnormal_thermal_nociception1.41800601
52MP0002909_abnormal_adrenal_gland1.40252227
53MP0002998_abnormal_bone_remodeling1.37878182
54MP0005076_abnormal_cell_differentiation1.37853626
55MP0001501_abnormal_sleep_pattern1.35026209
56MP0001970_abnormal_pain_threshold1.32337325
57MP0005451_abnormal_body_composition1.31642140
58MP0008569_lethality_at_weaning1.30948021
59MP0002184_abnormal_innervation1.29301427
60MP0001502_abnormal_circadian_rhythm1.29128115
61MP0004811_abnormal_neuron_physiology1.27304763
62MP0005257_abnormal_intraocular_pressure1.27023130
63MP0001800_abnormal_humoral_immune1.26374552
64MP0006082_CNS_inflammation1.25412587
65MP0005423_abnormal_somatic_nervous1.23480096
66MP0001835_abnormal_antigen_presentation1.23443270
67MP0002882_abnormal_neuron_morphology1.23144441
68MP0001533_abnormal_skeleton_physiology1.20996399
69MP0005166_decreased_susceptibility_to1.20876865
70MP0002332_abnormal_exercise_endurance1.19806026
71MP0001440_abnormal_grooming_behavior1.18558635
72MP0003866_abnormal_defecation1.17946769
73MP0002723_abnormal_immune_serum1.17565828
74MP0005671_abnormal_response_to1.17556254
75MP0001348_abnormal_lacrimal_gland1.17023118
76MP0003633_abnormal_nervous_system1.16987275
77MP0003303_peritoneal_inflammation1.16695695
78MP0003075_altered_response_to1.15885876
79MP0010155_abnormal_intestine_physiology1.15867252
80MP0003172_abnormal_lysosome_physiology1.14752010
81MP0004130_abnormal_muscle_cell1.14484968
82MP0002420_abnormal_adaptive_immunity1.14285983
83MP0003632_abnormal_nervous_system1.14175454
84MP0005666_abnormal_adipose_tissue1.14050575
85MP0001819_abnormal_immune_cell1.12508324
86MP0008874_decreased_physiological_sensi1.11328173
87MP0000685_abnormal_immune_system1.10385028
88MP0002452_abnormal_antigen_presenting1.10381980
89MP0005167_abnormal_blood-brain_barrier1.10303958
90MP0002148_abnormal_hypersensitivity_rea1.09154216
91MP0000604_amyloidosis1.05012381
92MP0010678_abnormal_skin_adnexa1.03566548
93MP0002822_catalepsy1.00905181
94MP0004043_abnormal_pH_regulation0.99540902
95MP0004510_myositis0.98740511
96MP0004742_abnormal_vestibular_system0.97455836
97MP0003283_abnormal_digestive_organ0.96728557
98MP0002229_neurodegeneration0.95859216
99MP0003631_nervous_system_phenotype0.94584868
100MP0001545_abnormal_hematopoietic_system0.92276989
101MP0005397_hematopoietic_system_phenotyp0.92276989
102MP0002405_respiratory_system_inflammati0.91910512
103MP0002067_abnormal_sensory_capabilities0.91213326
104MP0002066_abnormal_motor_capabilities/c0.90992541
105MP0003787_abnormal_imprinting0.90851883
106MP0002152_abnormal_brain_morphology0.89998248
107MP0005535_abnormal_body_temperature0.89796426
108MP0004185_abnormal_adipocyte_glucose0.89566606
109MP0003890_abnormal_embryonic-extraembry0.89461723
110MP0004381_abnormal_hair_follicle0.89144209
111MP0003938_abnormal_ear_development0.87165745
112MP0010234_abnormal_vibrissa_follicle0.86699778
113MP0001984_abnormal_olfaction0.86490656
114MP0005248_abnormal_Harderian_gland0.86483440
115MP0002090_abnormal_vision0.86266666
116MP0003698_abnormal_male_reproductive0.85400412
117MP0005464_abnormal_platelet_physiology0.85266697
118MP0003828_pulmonary_edema0.84879212
119MP0009333_abnormal_splenocyte_physiolog0.84584997
120MP0002752_abnormal_somatic_nervous0.84159598
121MP0001299_abnormal_eye_distance/0.83613319
122MP0005375_adipose_tissue_phenotype0.83403078
123MP0003045_fibrosis0.82119810
124MP0003861_abnormal_nervous_system0.81434847
125MP0000716_abnormal_immune_system0.81061710
126MP0002933_joint_inflammation0.79762070
127MP0001958_emphysema0.79569775
128MP0000762_abnormal_tongue_morphology0.79403300
129MP0009785_altered_susceptibility_to0.79139216
130MP0001968_abnormal_touch/_nociception0.78552633
131MP0000647_abnormal_sebaceous_gland0.77447674
132MP0000465_gastrointestinal_hemorrhage0.76812103
133MP0000534_abnormal_ureter_morphology0.76775947
134MP0003091_abnormal_cell_migration0.76636342
135MP0003279_aneurysm0.76257540
136MP0000383_abnormal_hair_follicle0.75976037
137MP0005310_abnormal_salivary_gland0.75671847
138MP0002557_abnormal_social/conspecific_i0.75347746
139MP0003121_genomic_imprinting0.73822374
140MP0003950_abnormal_plasma_membrane0.73296532
141MP0002398_abnormal_bone_marrow0.72365399
142MP0006292_abnormal_olfactory_placode0.71834065
143MP0008789_abnormal_olfactory_epithelium0.71633099
144MP0002233_abnormal_nose_morphology0.68909121
145MP0004142_abnormal_muscle_tone0.68402718
146MP0001851_eye_inflammation0.68343041
147MP0000428_abnormal_craniofacial_morphol0.67918540
148MP0000678_abnormal_parathyroid_gland0.67521457
149MP0000003_abnormal_adipose_tissue0.66359657
150MP0002735_abnormal_chemical_nociception0.65030081
151MP0004924_abnormal_behavior0.63283134
152MP0005386_behavior/neurological_phenoty0.63283134
153MP0003755_abnormal_palate_morphology0.62862007
154MP0000733_abnormal_muscle_development0.62725103
155MP0003453_abnormal_keratinocyte_physiol0.61410716
156MP0002092_abnormal_eye_morphology0.59971494

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.42967193
2Supranuclear gaze palsy (HP:0000605)4.13223466
3Neurofibrillary tangles (HP:0002185)4.06699809
4Abnormality of the lower motor neuron (HP:0002366)3.76772149
5Bilateral microphthalmos (HP:0007633)3.64795156
6Myokymia (HP:0002411)3.33504920
7Cerebral inclusion bodies (HP:0100314)3.31189823
8Eczematoid dermatitis (HP:0000976)3.26257325
9Abnormality of the corticospinal tract (HP:0002492)3.25739429
10Hepatoblastoma (HP:0002884)3.06841500
11Spastic tetraparesis (HP:0001285)3.00624979
12Amyotrophic lateral sclerosis (HP:0007354)2.99146418
13Difficulty running (HP:0009046)2.98333793
14Abnormality of binocular vision (HP:0011514)2.93811942
15Diplopia (HP:0000651)2.93811942
16Sensory axonal neuropathy (HP:0003390)2.87041223
17Hemiparesis (HP:0001269)2.81953653
18Increased IgE level (HP:0003212)2.81456516
19Papilledema (HP:0001085)2.78895891
20Abnormality of liposaccharide metabolism (HP:0010968)2.73471702
21Abnormality of glycosphingolipid metabolism (HP:0004343)2.73471702
22Abnormality of glycolipid metabolism (HP:0010969)2.73471702
23Annular pancreas (HP:0001734)2.70415750
24Ankle clonus (HP:0011448)2.68022479
25Cerebral aneurysm (HP:0004944)2.60821283
26Neoplasm of the heart (HP:0100544)2.56695132
27Peripheral hypomyelination (HP:0007182)2.56183227
28Onion bulb formation (HP:0003383)2.54557834
29Neuronal loss in central nervous system (HP:0002529)2.52706704
30Action tremor (HP:0002345)2.51858909
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.50423657
32Interstitial pulmonary disease (HP:0006530)2.50183188
33Focal seizures (HP:0007359)2.45875710
34Amblyopia (HP:0000646)2.44678822
35Apathy (HP:0000741)2.42414615
36Hyperacusis (HP:0010780)2.41035613
37Upper limb amyotrophy (HP:0009129)2.40755811
38Distal upper limb amyotrophy (HP:0007149)2.40755811
39Dysostosis multiplex (HP:0000943)2.38199548
40Broad face (HP:0000283)2.29597461
41Abnormality of the fingertips (HP:0001211)2.29314091
42Intention tremor (HP:0002080)2.27626700
43Epileptic encephalopathy (HP:0200134)2.21860824
44Diminished motivation (HP:0000745)2.19117021
45Hand muscle atrophy (HP:0009130)2.18029476
46Megalencephaly (HP:0001355)2.17138619
47Slow saccadic eye movements (HP:0000514)2.16024212
48Colitis (HP:0002583)2.15601925
49Cellulitis (HP:0100658)2.14833534
50Thin bony cortex (HP:0002753)2.13175035
51Abnormality of macrophages (HP:0004311)2.12683717
52Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.09670342
53Recurrent bacterial skin infections (HP:0005406)2.09482929
54Achilles tendon contracture (HP:0001771)2.09065001
55Lower limb muscle weakness (HP:0007340)2.08229218
56Spastic gait (HP:0002064)2.08055074
57Abnormality of the salivary glands (HP:0010286)2.04971458
58Macroorchidism (HP:0000053)2.03897190
59Generalized hypotonia (HP:0001290)2.02819280
60Abnormality of the nasal mucosa (HP:0000433)2.02646179
61Clumsiness (HP:0002312)2.02349045
62Abnormal auditory evoked potentials (HP:0006958)2.01968774
63Rapidly progressive (HP:0003678)2.01576473
64Truncal ataxia (HP:0002078)2.01329267
65Axonal loss (HP:0003447)2.01308329
66Systemic lupus erythematosus (HP:0002725)2.00578970
67Dysmetria (HP:0001310)1.99772647
68Hypercortisolism (HP:0001578)1.98064146
69Gingivitis (HP:0000230)1.98029252
70Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98003886
71Degeneration of the lateral corticospinal tracts (HP:0002314)1.98003886
72Fused cervical vertebrae (HP:0002949)1.97967910
73Abnormality of the periventricular white matter (HP:0002518)1.94389257
74Dynein arm defect of respiratory motile cilia (HP:0012255)1.92648227
75Absent/shortened dynein arms (HP:0200106)1.92648227
76Myositis (HP:0100614)1.92176878
77Abnormality of the musculature of the hand (HP:0001421)1.92000655
78Increased cerebral lipofuscin (HP:0011813)1.89697668
79Buphthalmos (HP:0000557)1.89610064
80Insidious onset (HP:0003587)1.89032116
81Termporal pattern (HP:0011008)1.89032116
82Recurrent abscess formation (HP:0002722)1.88731803
83Large earlobe (HP:0009748)1.88434732
84Mediastinal lymphadenopathy (HP:0100721)1.87979118
85Focal motor seizures (HP:0011153)1.86782582
86Aplasia involving bones of the extremities (HP:0009825)1.86631161
87Aplasia involving bones of the upper limbs (HP:0009823)1.86631161
88Aplasia of the phalanges of the hand (HP:0009802)1.86631161
89Distal lower limb amyotrophy (HP:0008944)1.86605337
90Hyperparathyroidism (HP:0000843)1.85627303
91Polygenic inheritance (HP:0010982)1.84535343
92Mutism (HP:0002300)1.84363964
93Scanning speech (HP:0002168)1.84218161
94Open mouth (HP:0000194)1.83489247
95Bowel incontinence (HP:0002607)1.83473018
96Turricephaly (HP:0000262)1.82197270
97Segmental peripheral demyelination/remyelination (HP:0003481)1.82157542
98Rib fusion (HP:0000902)1.81368769
99Spinal canal stenosis (HP:0003416)1.81248365
100Hemiplegia (HP:0002301)1.80781086
101Amyloidosis (HP:0011034)1.80165235
102Lower limb amyotrophy (HP:0007210)1.79800291
103Stereotypic behavior (HP:0000733)1.78700317
104Difficulty walking (HP:0002355)1.77354487
105Increased neuronal autofluorescent lipopigment (HP:0002074)1.76317436
106Dysmetric saccades (HP:0000641)1.75901608
107Abnormality of the astrocytes (HP:0100707)1.75180201
108Astrocytoma (HP:0009592)1.75180201
109Pointed chin (HP:0000307)1.74916004
110Foot dorsiflexor weakness (HP:0009027)1.74776244
111Visual hallucinations (HP:0002367)1.74627917
112Insomnia (HP:0100785)1.74299297
113Centrally nucleated skeletal muscle fibers (HP:0003687)1.73917363
114Nuclear cataract (HP:0100018)1.73399242
115Gastrointestinal inflammation (HP:0004386)1.72600544
116Sleep apnea (HP:0010535)1.72124440
117Abnormal large intestine physiology (HP:0012700)1.71014829
118Orchitis (HP:0100796)1.70819062
119Mucopolysacchariduria (HP:0008155)1.70371554
120Urinary glycosaminoglycan excretion (HP:0003541)1.70371554
121Lower limb asymmetry (HP:0100559)1.69870066
122Hyperventilation (HP:0002883)1.69591497
123Renal duplication (HP:0000075)1.69115501
124Abnormality of mucopolysaccharide metabolism (HP:0011020)1.68972374
125Abnormality of polysaccharide metabolism (HP:0011012)1.68972374
126Abnormality of glycosaminoglycan metabolism (HP:0004371)1.68972374
127Urinary bladder sphincter dysfunction (HP:0002839)1.68682329
128Limb dystonia (HP:0002451)1.66680256
129Abnormal eating behavior (HP:0100738)1.66637653
130Loss of speech (HP:0002371)1.66085033
131Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.66007960
132Decreased motor nerve conduction velocity (HP:0003431)1.65667049
133Spontaneous hematomas (HP:0007420)1.64990228
134Stridor (HP:0010307)1.64040616
135Nasal polyposis (HP:0100582)1.63518694
136Dementia (HP:0000726)1.63368738
137Atelectasis (HP:0100750)1.62985991
138Growth hormone excess (HP:0000845)1.62612236
139Dialeptic seizures (HP:0011146)1.62399715
140Mitral regurgitation (HP:0001653)1.62098031
141Mildly elevated creatine phosphokinase (HP:0008180)1.62071715
142Atonic seizures (HP:0010819)1.61927607
143Febrile seizures (HP:0002373)1.61658080
144Germ cell neoplasia (HP:0100728)1.61188843
145Abnormality of the distal phalanx of the thumb (HP:0009617)1.60725312
146Resting tremor (HP:0002322)1.60114550
147Tetraplegia (HP:0002445)1.59979044
148Shallow orbits (HP:0000586)1.59924773
149Depression (HP:0000716)1.59909696
150Rigidity (HP:0002063)1.59784827
151Abnormality of the Achilles tendon (HP:0005109)1.59692222
152Inflammation of the large intestine (HP:0002037)1.59123681
153Dysdiadochokinesis (HP:0002075)1.58713157
154Distal sensory impairment (HP:0002936)1.57989988
155Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.57738410
156Partial duplication of thumb phalanx (HP:0009944)1.54814682
157Horizontal nystagmus (HP:0000666)1.54300774
158Dysphonia (HP:0001618)1.54047117
159Prominent occiput (HP:0000269)1.53007272
160Hypopigmentation of the fundus (HP:0007894)1.52028088
161Aplasia/Hypoplasia of the fovea (HP:0008060)1.50813141
162Hypoplasia of the fovea (HP:0007750)1.50813141
163Akinesia (HP:0002304)1.50405877
164Multiple enchondromatosis (HP:0005701)1.49898361
165Progressive cerebellar ataxia (HP:0002073)1.49889497
166Failure to thrive in infancy (HP:0001531)1.49549053
167Alacrima (HP:0000522)1.48383886
168Postural instability (HP:0002172)1.48328210

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.66084066
2GRK53.03961555
3TYRO33.01927270
4PRKD32.90098296
5MAP3K92.87786723
6ERN12.68711914
7NTRK12.54872820
8WNK12.22109904
9MARK12.14306835
10EPHB12.08614393
11PAK62.03458339
12KSR21.95017600
13ICK1.93626158
14STK391.85411918
15MAP4K11.84573444
16EPHA41.81101783
17IRAK31.62520126
18EEF2K1.62115908
19MARK21.56596082
20TNK21.49691318
21NTRK21.46938477
22FES1.45946901
23RIPK11.44656010
24SMG11.39429902
25GRK61.36379361
26NTRK31.35468609
27FGFR41.34095464
28MAP3K111.32410861
29MOS1.31133766
30CDC42BPA1.24714777
31PRPF4B1.21426161
32CSF1R1.20776414
33TYK21.18682770
34MAPK71.17739898
35MATK1.16770481
36MAP3K141.15301527
37TAOK11.13746677
38BLK1.13025183
39ZAP701.11896669
40MAP3K101.11209663
41MAP2K31.11061614
42CSK1.10408446
43DAPK21.09182394
44MAPK121.05375748
45BMX1.04818529
46TRIB31.03295760
47TBK11.02979622
48ADRBK21.02929881
49TESK11.02557639
50TAOK21.01970311
51JAK10.99225336
52PKN10.98781462
53MAP3K20.97515228
54PRKG20.97205590
55PRKD20.96939981
56ALK0.96922620
57MAPK150.96272390
58CDK50.94189915
59DDR20.92459461
60GRK10.91063950
61TGFBR20.90075030
62PHKG10.89889637
63PHKG20.89889637
64CAMK1G0.88451186
65SGK30.88017657
66PKN20.87417763
67GRK70.87396267
68CAMKK10.87169892
69RIPK40.85975129
70RPS6KA20.85246473
71HIPK20.84012688
72SIK30.83767017
73MAP3K30.83719370
74SIK20.82647109
75PRKCH0.81951517
76MAP3K130.80743689
77PDK20.80690237
78OXSR10.80065285
79MAP3K60.80014380
80PAK30.79641463
81UHMK10.79442930
82MAP2K40.79441540
83MET0.77766897
84ARAF0.76933197
85MINK10.76018937
86IRAK20.75755055
87CAMK40.75668808
88JAK20.73982976
89CDK150.72710784
90RET0.72490369
91WNK40.72248912
92STK380.72105268
93DYRK20.71425288
94MAP3K10.71396961
95HCK0.71010976
96CDK140.70989224
97KSR10.70654786
98FGFR20.69746861
99PTK60.68978777
100PTK20.68156963
101IKBKE0.68047204
102CAMK1D0.67783660
103CDK180.67714391
104LATS20.66793614
105PDGFRB0.66679136
106PDGFRA0.66055157
107BTK0.65544524
108SGK20.65006174
109SIK10.62620259
110DYRK1B0.62016466
111CDK11A0.61769522
112PDK10.61376973
113NEK60.61059726
114SGK4940.60264396
115SGK2230.60264396
116JAK30.59426377
117MAP3K40.59345328
118EPHA30.58054062
119LMTK20.56979170
120IRAK40.56425977
121FGR0.56403502
122RPS6KL10.54314780
123RPS6KC10.54314780
124FER0.53814388
125BCR0.53323300
126LIMK10.53275218
127PDPK10.52794698
128ITK0.52438302
129MAP3K70.52112923
130ROCK20.51392735
131PTK2B0.50558983
132SYK0.50549747
133TTN0.50020879
134CSNK1G20.49302868
135PRKD10.48867443
136MAPK40.48783082
137FYN0.48749525
138MAPK100.48098967
139ERBB20.47665467
140CAMK2B0.47631018
141STK110.46326435
142FGFR30.44688349
143MAPKAPK50.42416230
144CSNK1A1L0.42174219
145MTOR0.41699804
146PDK30.40722668

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.32724400
2Synaptic vesicle cycle_Homo sapiens_hsa047211.96141336
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89694917
4Other glycan degradation_Homo sapiens_hsa005111.64984113
5Glutamatergic synapse_Homo sapiens_hsa047241.64099143
6GABAergic synapse_Homo sapiens_hsa047271.62603727
7Dorso-ventral axis formation_Homo sapiens_hsa043201.49596685
8Notch signaling pathway_Homo sapiens_hsa043301.47771679
9Vitamin B6 metabolism_Homo sapiens_hsa007501.45026611
10Acute myeloid leukemia_Homo sapiens_hsa052211.42173017
11Axon guidance_Homo sapiens_hsa043601.41107518
12Circadian entrainment_Homo sapiens_hsa047131.39199367
13Long-term potentiation_Homo sapiens_hsa047201.37581307
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37151238
15Olfactory transduction_Homo sapiens_hsa047401.34166090
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31870805
17Salivary secretion_Homo sapiens_hsa049701.27579054
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26444591
19Long-term depression_Homo sapiens_hsa047301.26379135
20Leishmaniasis_Homo sapiens_hsa051401.26069593
21* Phospholipase D signaling pathway_Homo sapiens_hsa040721.23886664
22Morphine addiction_Homo sapiens_hsa050321.23520041
23Chronic myeloid leukemia_Homo sapiens_hsa052201.23369579
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21925899
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21544730
26Prion diseases_Homo sapiens_hsa050201.19801548
27Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19449933
28Dopaminergic synapse_Homo sapiens_hsa047281.17153450
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16753857
30Cholinergic synapse_Homo sapiens_hsa047251.16685582
31T cell receptor signaling pathway_Homo sapiens_hsa046601.14712600
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13022654
33Gastric acid secretion_Homo sapiens_hsa049711.12605413
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12270459
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12197290
36Renal cell carcinoma_Homo sapiens_hsa052111.11682573
37Renin secretion_Homo sapiens_hsa049241.11088349
38Cocaine addiction_Homo sapiens_hsa050301.11076075
39Sphingolipid signaling pathway_Homo sapiens_hsa040711.10922498
40Type II diabetes mellitus_Homo sapiens_hsa049301.10807474
41Collecting duct acid secretion_Homo sapiens_hsa049661.10599838
42Ether lipid metabolism_Homo sapiens_hsa005651.09988417
43Serotonergic synapse_Homo sapiens_hsa047261.09877530
44GnRH signaling pathway_Homo sapiens_hsa049121.09649534
45Endocytosis_Homo sapiens_hsa041441.09024317
46TNF signaling pathway_Homo sapiens_hsa046681.07403920
47Nicotine addiction_Homo sapiens_hsa050331.06441638
48VEGF signaling pathway_Homo sapiens_hsa043701.05392570
49ErbB signaling pathway_Homo sapiens_hsa040121.00846818
50Prolactin signaling pathway_Homo sapiens_hsa049171.00460780
51cAMP signaling pathway_Homo sapiens_hsa040240.99972597
52Amphetamine addiction_Homo sapiens_hsa050310.99659541
53Insulin secretion_Homo sapiens_hsa049110.99655696
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.99254924
55mTOR signaling pathway_Homo sapiens_hsa041500.99225795
56Gap junction_Homo sapiens_hsa045400.98027302
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96570591
58Oxytocin signaling pathway_Homo sapiens_hsa049210.96445668
59Estrogen signaling pathway_Homo sapiens_hsa049150.95642988
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95216415
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94905129
62Toxoplasmosis_Homo sapiens_hsa051450.94785385
63Lysosome_Homo sapiens_hsa041420.94019212
64Taste transduction_Homo sapiens_hsa047420.92896991
65Glioma_Homo sapiens_hsa052140.91985977
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91969680
67Staphylococcus aureus infection_Homo sapiens_hsa051500.91893870
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90350926
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90066456
70Hepatitis C_Homo sapiens_hsa051600.88604389
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87832937
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.86626742
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.84583045
74Inositol phosphate metabolism_Homo sapiens_hsa005620.82693599
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81832551
76MAPK signaling pathway_Homo sapiens_hsa040100.81547267
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.81373363
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80766845
79Calcium signaling pathway_Homo sapiens_hsa040200.78902257
80Influenza A_Homo sapiens_hsa051640.78625076
81Pertussis_Homo sapiens_hsa051330.78618323
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78459287
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78331371
84* Pancreatic cancer_Homo sapiens_hsa052120.77954952
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77704957
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77698583
87Amoebiasis_Homo sapiens_hsa051460.77427514
88Insulin signaling pathway_Homo sapiens_hsa049100.77368684
89Hedgehog signaling pathway_Homo sapiens_hsa043400.76917441
90* Choline metabolism in cancer_Homo sapiens_hsa052310.76500901
91Vibrio cholerae infection_Homo sapiens_hsa051100.76496735
92Tight junction_Homo sapiens_hsa045300.76326424
93* Rap1 signaling pathway_Homo sapiens_hsa040150.75570068
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74911313
95* Ras signaling pathway_Homo sapiens_hsa040140.74720029
96African trypanosomiasis_Homo sapiens_hsa051430.73718988
97Melanogenesis_Homo sapiens_hsa049160.73147052
98Graft-versus-host disease_Homo sapiens_hsa053320.73007038
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71890013
100Platelet activation_Homo sapiens_hsa046110.71381147
101Salmonella infection_Homo sapiens_hsa051320.71114784
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71013529
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70013927
104B cell receptor signaling pathway_Homo sapiens_hsa046620.69881070
105Allograft rejection_Homo sapiens_hsa053300.69787083
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69700180
107Hepatitis B_Homo sapiens_hsa051610.69433853
108Tuberculosis_Homo sapiens_hsa051520.69132359
109Proteoglycans in cancer_Homo sapiens_hsa052050.68909010
110Mineral absorption_Homo sapiens_hsa049780.68250416
111Chemokine signaling pathway_Homo sapiens_hsa040620.67808075
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67561798
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67220170
114Endometrial cancer_Homo sapiens_hsa052130.66856079
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65005535
116Non-small cell lung cancer_Homo sapiens_hsa052230.64991083
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64656540
118Rheumatoid arthritis_Homo sapiens_hsa053230.64354880
119Ovarian steroidogenesis_Homo sapiens_hsa049130.63357752
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63196838
121Linoleic acid metabolism_Homo sapiens_hsa005910.62792011
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.62508576
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62099272
124Dilated cardiomyopathy_Homo sapiens_hsa054140.61851532
125Osteoclast differentiation_Homo sapiens_hsa043800.61756970
126HIF-1 signaling pathway_Homo sapiens_hsa040660.61222406
127Phagosome_Homo sapiens_hsa041450.60997252
128Fatty acid biosynthesis_Homo sapiens_hsa000610.60461882
129Hippo signaling pathway_Homo sapiens_hsa043900.60423828
130Malaria_Homo sapiens_hsa051440.59965767
131Pancreatic secretion_Homo sapiens_hsa049720.57536925
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.57446389
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.56182728
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56101473
135Focal adhesion_Homo sapiens_hsa045100.54110182

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