RALY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) gene family. This protein may play a role in pre-mRNA splicing and in embryonic development. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.26035300
2heterochromatin organization (GO:0070828)4.64706684
3protein localization to kinetochore (GO:0034501)4.38556295
4folic acid-containing compound biosynthetic process (GO:0009396)4.26582583
5negative regulation of erythrocyte differentiation (GO:0045647)4.22895444
6regulation of translational fidelity (GO:0006450)3.98994714
7COPI coating of Golgi vesicle (GO:0048205)3.95805496
8Golgi transport vesicle coating (GO:0048200)3.95805496
9negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.93063770
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.76089246
11antigen processing and presentation of endogenous antigen (GO:0019883)3.68901124
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.66658432
13protein localization to chromosome, centromeric region (GO:0071459)3.65192674
14mitotic nuclear envelope disassembly (GO:0007077)3.64901508
15NIK/NF-kappaB signaling (GO:0038061)3.64774938
16viral transcription (GO:0019083)3.62818580
17negative regulation of RNA splicing (GO:0033119)3.57404612
18DNA strand elongation involved in DNA replication (GO:0006271)3.57265303
19DNA replication-dependent nucleosome assembly (GO:0006335)3.55784302
20DNA replication-dependent nucleosome organization (GO:0034723)3.55784302
21negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.50775165
22nuclear pore organization (GO:0006999)3.49928904
23sister chromatid segregation (GO:0000819)3.49749961
24dosage compensation (GO:0007549)3.48719381
25regulation of translational termination (GO:0006449)3.48233791
26translational termination (GO:0006415)3.48204562
27regulation of mammary gland epithelial cell proliferation (GO:0033599)3.46358411
28membrane disassembly (GO:0030397)3.45102257
29nuclear envelope disassembly (GO:0051081)3.45102257
30nuclear pore complex assembly (GO:0051292)3.43065146
313-UTR-mediated mRNA stabilization (GO:0070935)3.43058787
32mitotic sister chromatid segregation (GO:0000070)3.43046857
33mRNA stabilization (GO:0048255)3.42111698
34RNA stabilization (GO:0043489)3.42111698
35modulation by virus of host process (GO:0019054)3.39665534
36positive regulation of gamma-delta T cell activation (GO:0046645)3.39256248
37pinocytosis (GO:0006907)3.39195322
38mitotic chromosome condensation (GO:0007076)3.39063602
39positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.36539209
40DNA strand elongation (GO:0022616)3.34935589
41DNA replication initiation (GO:0006270)3.34006775
42maternal placenta development (GO:0001893)3.33877755
43DNA duplex unwinding (GO:0032508)3.33005666
44chromatin assembly (GO:0031497)3.32556112
45barbed-end actin filament capping (GO:0051016)3.31907701
46deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.30731708
47modulation by symbiont of host cellular process (GO:0044068)3.30107904
48DNA geometric change (GO:0032392)3.28839474
49pre-miRNA processing (GO:0031054)3.27553874
50translational elongation (GO:0006414)3.25767872
51negative regulation of mRNA processing (GO:0050686)3.23978083
52regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.21644063
53peptidyl-lysine dimethylation (GO:0018027)3.21100673
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.17199202
55Arp2/3 complex-mediated actin nucleation (GO:0034314)3.16972877
56nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.16373517
57negative regulation of histone methylation (GO:0031061)3.16373022
58pentose-phosphate shunt (GO:0006098)3.16127285
59protein retention in ER lumen (GO:0006621)3.15326847
60proline biosynthetic process (GO:0006561)3.13322091
61formation of translation preinitiation complex (GO:0001731)3.10650134
62ribosomal small subunit assembly (GO:0000028)3.09812886
63GDP-mannose metabolic process (GO:0019673)3.09491783
64T cell apoptotic process (GO:0070231)3.06546743
65regulation of protein heterodimerization activity (GO:0043497)3.06342890
66telomere maintenance via semi-conservative replication (GO:0032201)3.03663857
67modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.03521864
68positive regulation by organism of defense response of other organism involved in symbiotic interact3.03521864
69modulation by symbiont of host immune response (GO:0052553)3.03521864
70positive regulation by symbiont of host defense response (GO:0052509)3.03521864
71modulation by symbiont of host defense response (GO:0052031)3.03521864
72modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.03521864
73positive regulation of histone deacetylation (GO:0031065)3.03219862
74mitotic G1 DNA damage checkpoint (GO:0031571)3.02824101
75translational initiation (GO:0006413)3.01775675
76regulation of sister chromatid cohesion (GO:0007063)3.00719907
77glucose catabolic process (GO:0006007)2.99476908
78cellular response to virus (GO:0098586)2.99015360
79mature B cell differentiation involved in immune response (GO:0002313)2.98085236
80Peyers patch development (GO:0048541)2.97980416
81mucosal-associated lymphoid tissue development (GO:0048537)2.97980416
82negative regulation of mRNA metabolic process (GO:1903312)2.97697459
83maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.96276180
84retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.95933135
85mitotic nuclear envelope reassembly (GO:0007084)2.95726429
86nuclear envelope reassembly (GO:0031468)2.95726429
87response to peptidoglycan (GO:0032494)2.94469404
88IMP biosynthetic process (GO:0006188)2.93808671
89spliceosomal tri-snRNP complex assembly (GO:0000244)2.93029306
90regulation of defense response to virus by virus (GO:0050690)2.92765445
91regulation of histone H3-K9 methylation (GO:0051570)2.91879411
92translesion synthesis (GO:0019985)2.91509428
93nuclear envelope organization (GO:0006998)2.90186367
94response to muramyl dipeptide (GO:0032495)2.85401653
95response to UV-C (GO:0010225)2.83451939
96negative regulation of myeloid cell apoptotic process (GO:0033033)2.80504564
97regulation of superoxide anion generation (GO:0032928)2.80043797
98peptidyl-arginine omega-N-methylation (GO:0035247)2.79300538
99intracellular estrogen receptor signaling pathway (GO:0030520)2.79294256
100UV protection (GO:0009650)2.78652839
101positive regulation of Cdc42 GTPase activity (GO:0043089)2.78424914
102negative regulation of cell size (GO:0045792)2.78409634
103regulation of monocyte differentiation (GO:0045655)2.77127272
104endothelial tube morphogenesis (GO:0061154)2.75514882
105morphogenesis of an endothelium (GO:0003159)2.75514882
106apoptotic process involved in morphogenesis (GO:0060561)2.74469755
107chromatin assembly or disassembly (GO:0006333)2.74141542
108activation of MAPKKK activity (GO:0000185)2.73382332
109regulation of gene silencing by RNA (GO:0060966)2.73285732
110regulation of posttranscriptional gene silencing (GO:0060147)2.73285732
111regulation of gene silencing by miRNA (GO:0060964)2.73285732
112positive regulation of SMAD protein import into nucleus (GO:0060391)2.72379160
113viral life cycle (GO:0019058)2.71164021
114glucocorticoid receptor signaling pathway (GO:0042921)2.70559139
115protein complex disassembly (GO:0043241)2.69463923
116ribosomal small subunit biogenesis (GO:0042274)2.69073167
117mitotic G1/S transition checkpoint (GO:0044819)2.68615745
118histone H2A monoubiquitination (GO:0035518)2.68431312
119cellular protein complex disassembly (GO:0043624)2.67996401
120IMP metabolic process (GO:0046040)2.67845538
121regulation of hippo signaling (GO:0035330)2.67654808
122protein localization to chromosome (GO:0034502)2.66019759
123NADPH regeneration (GO:0006740)2.65975866
124paraxial mesoderm development (GO:0048339)2.65942617
125negative regulation of necroptotic process (GO:0060546)2.65115593
126regulation of type I interferon-mediated signaling pathway (GO:0060338)2.64951263
127alternative mRNA splicing, via spliceosome (GO:0000380)2.63762752
128positive thymic T cell selection (GO:0045059)2.63714117
129immunoglobulin mediated immune response (GO:0016064)2.62535734
130regulation of spindle organization (GO:0090224)2.62115782
131mitotic recombination (GO:0006312)2.61239108
132regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.60799313
133regulation of necrotic cell death (GO:0010939)2.60702972
134regulation of mRNA stability (GO:0043488)2.60092890
135protein maturation by protein folding (GO:0022417)2.59180780
136protein localization to endosome (GO:0036010)2.58940826
137leukocyte aggregation (GO:0070486)2.58829165
138positive regulation of chromosome segregation (GO:0051984)2.58171693
139DNA conformation change (GO:0071103)2.58066707
140maturation of SSU-rRNA (GO:0030490)2.57579058
141positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.56953270
142positive regulation of B cell differentiation (GO:0045579)2.56073363
143telomere maintenance via recombination (GO:0000722)2.54882459
144establishment of apical/basal cell polarity (GO:0035089)2.54821142
145SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.54647394
146regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.53219651
147lymphocyte apoptotic process (GO:0070227)2.53129877
148regulation of SMAD protein import into nucleus (GO:0060390)2.52961717
149modulation by virus of host morphology or physiology (GO:0019048)2.51963166
150positive regulation of protein deacetylation (GO:0090312)2.51933187
151pore complex assembly (GO:0046931)2.49152970
152protein-DNA complex disassembly (GO:0032986)2.47520599
153nucleosome disassembly (GO:0006337)2.47520599
154protein targeting to ER (GO:0045047)2.47150852
155thymic T cell selection (GO:0045061)2.46848836
156regulation of RNA stability (GO:0043487)2.46255095
157cellular response to interleukin-4 (GO:0071353)2.45933105
158mannose metabolic process (GO:0006013)2.45337440
159chromosome condensation (GO:0030261)2.44912875
160regulation of mitotic spindle organization (GO:0060236)2.44055494
161regulation of necroptotic process (GO:0060544)2.42383536
162pentose metabolic process (GO:0019321)2.41581316
163embryonic process involved in female pregnancy (GO:0060136)2.40754070
164negative regulation of phagocytosis (GO:0050765)2.40039468
165virion assembly (GO:0019068)2.39523794
166regulation of leukocyte degranulation (GO:0043300)2.39101592
167regulation of early endosome to late endosome transport (GO:2000641)2.38313726
168glucose 6-phosphate metabolic process (GO:0051156)2.38025052
169stress fiber assembly (GO:0043149)2.34875997
170regulation of glucose import in response to insulin stimulus (GO:2001273)2.34812360
171negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.33965931
172negative regulation of cell killing (GO:0031342)2.33965931
173regulation of gamma-delta T cell differentiation (GO:0045586)2.33737701
174cellular hyperosmotic response (GO:0071474)2.33073827
175negative regulation of DNA-templated transcription, elongation (GO:0032785)2.31161691
176negative regulation of B cell apoptotic process (GO:0002903)2.28819281
177regulation of mast cell degranulation (GO:0043304)2.27538424
178actin nucleation (GO:0045010)2.27183676
179response to interleukin-4 (GO:0070670)2.25534832
180regulation of gamma-delta T cell activation (GO:0046643)2.25271553
181detection of bacterium (GO:0016045)2.24836016
182epithelial cell differentiation involved in prostate gland development (GO:0060742)2.24796218
183post-embryonic morphogenesis (GO:0009886)2.24693552

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.34293720
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.36596021
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45922049
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.31277366
5* MYC_22102868_ChIP-Seq_BL_Human3.22151864
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.78809588
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.70077996
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.64404935
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59126417
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42674282
11VDR_21846776_ChIP-Seq_THP-1_Human2.39907994
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.20327571
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.00708518
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93916114
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92256644
16ELK3_25401928_ChIP-Seq_HUVEC_Human1.81430921
17* TCF7_22412390_ChIP-Seq_EML_Mouse1.78502260
18AR_21909140_ChIP-Seq_LNCAP_Human1.75412652
19XRN2_22483619_ChIP-Seq_HELA_Human1.75101911
20MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71716011
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68694994
22* KDM2B_26808549_Chip-Seq_DND41_Human1.63976219
23E2F1_21310950_ChIP-Seq_MCF-7_Human1.60615899
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59553445
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56376231
26NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55481761
27TET1_21451524_ChIP-Seq_MESCs_Mouse1.53726229
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53160486
29CIITA_25753668_ChIP-Seq_RAJI_Human1.52512928
30UTX_26944678_Chip-Seq_JUKART_Human1.51068054
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.50893961
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.49329898
33MAF_26560356_Chip-Seq_TH1_Human1.48658702
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48312670
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.46872852
36CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45026275
37* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45004151
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44017062
39* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43064760
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40632243
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39962404
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37970937
43* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37040918
44SA1_27219007_Chip-Seq_ERYTHROID_Human1.36541340
45KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36180337
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35979274
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.35967819
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35157183
49* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35014780
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.34117013
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33704364
52ATF3_27146783_Chip-Seq_COLON_Human1.32954549
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31120784
54CLOCK_20551151_ChIP-Seq_293T_Human1.30552453
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29009337
56LXR_22292898_ChIP-Seq_THP-1_Human1.27339378
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26739558
58BCL6_27268052_Chip-Seq_Bcells_Human1.26472946
59KDM5A_27292631_Chip-Seq_BREAST_Human1.24526026
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24284546
61RACK7_27058665_Chip-Seq_MCF-7_Human1.23428085
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21964438
63BCOR_27268052_Chip-Seq_Bcells_Human1.21397412
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21250375
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20386314
66* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19018911
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18926062
68PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18854440
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18349699
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18057801
71VDR_24763502_ChIP-Seq_THP-1_Human1.17988930
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17155714
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17015193
74NCOR1_26117541_ChIP-Seq_K562_Human1.16639276
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16400699
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15670080
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15165440
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15052671
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14723086
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14490282
81NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13623447
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13598210
83SPI1_23547873_ChIP-Seq_NB4_Human1.13434425
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12748252
85* SMC4_20622854_ChIP-Seq_HELA_Human1.12265187
86* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12117099
87TFEB_21752829_ChIP-Seq_HELA_Human1.11814956
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10738570
89KDM2B_26808549_Chip-Seq_K562_Human1.10421709
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09857679
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09559355
92CTCF_26484167_Chip-Seq_Bcells_Mouse1.08083905
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07715513
94* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07659276
95* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07620252
96RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07144200
97ETS1_20019798_ChIP-Seq_JURKAT_Human1.07129254
98MAF_26560356_Chip-Seq_TH2_Human1.06622835
99SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06579441
100KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06564118
101THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05918146
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05726566
103* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05569592
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05069300
105* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04669589
106SCL_19346495_ChIP-Seq_HPC-7_Human1.03561539
107GATA1_19941827_ChIP-Seq_MEL_Mouse1.03276251
108* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02869217
109* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02477724
110KDM2B_26808549_Chip-Seq_JURKAT_Human1.02382354
111E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01622010
112* GABP_19822575_ChIP-Seq_HepG2_Human1.01354844
113RUNX1_22412390_ChIP-Seq_EML_Mouse1.00835743
114MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00689016
115TTF2_22483619_ChIP-Seq_HELA_Human1.00551502
116* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99537760
117GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99384814
118ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99235354
119MYB_26560356_Chip-Seq_TH2_Human0.98942579
120NANOG_21062744_ChIP-ChIP_HESCs_Human0.98637863
121GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98391300
122ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98115875
123* ZNF263_19887448_ChIP-Seq_K562_Human0.97852512
124STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97424636
125MYB_26560356_Chip-Seq_TH1_Human0.96416395
126CHD1_26751641_Chip-Seq_LNCaP_Human0.96400173
127* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96316139
128CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95407642
129TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93246487
130NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92040665
131TP53_22127205_ChIP-Seq_IMR90_Human0.91393630
132DCP1A_22483619_ChIP-Seq_HELA_Human0.91191516
133* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90383049
134P68_20966046_ChIP-Seq_HELA_Human0.88778611
135FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88741336
136E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88017730
137NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88008792

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.85868798
2MP0005451_abnormal_body_composition3.43592679
3MP0005058_abnormal_lysosome_morphology3.33059579
4MP0010352_gastrointestinal_tract_polyps3.09232919
5MP0003436_decreased_susceptibility_to2.88877758
6MP0003111_abnormal_nucleus_morphology2.84161207
7MP0003693_abnormal_embryo_hatching2.71040057
8MP0004957_abnormal_blastocyst_morpholog2.66279412
9MP0005076_abnormal_cell_differentiation2.52980220
10MP0008260_abnormal_autophagy2.52297993
11MP0003077_abnormal_cell_cycle2.52091331
12MP0010094_abnormal_chromosome_stability2.38320800
13MP0010307_abnormal_tumor_latency2.18965501
14MP0009278_abnormal_bone_marrow2.14243380
15MP0001730_embryonic_growth_arrest2.09845004
16MP0005464_abnormal_platelet_physiology2.01672596
17MP0001835_abnormal_antigen_presentation2.00801497
18MP0002396_abnormal_hematopoietic_system2.00783376
19MP0003566_abnormal_cell_adhesion1.98807096
20MP0000350_abnormal_cell_proliferation1.92895929
21MP0005025_abnormal_response_to1.90847574
22MP0004858_abnormal_nervous_system1.89678509
23MP0003172_abnormal_lysosome_physiology1.86424512
24MP0003300_gastrointestinal_ulcer1.84984675
25MP0001849_ear_inflammation1.80137818
26MP0008438_abnormal_cutaneous_collagen1.78090168
27MP0006054_spinal_hemorrhage1.75219793
28MP0005000_abnormal_immune_tolerance1.74259995
29MP0004808_abnormal_hematopoietic_stem1.73932678
30MP0008007_abnormal_cellular_replicative1.71451643
31MP0004197_abnormal_fetal_growth/weight/1.71039363
32MP0003191_abnormal_cellular_cholesterol1.70775208
33MP0000733_abnormal_muscle_development1.69982949
34MP0002419_abnormal_innate_immunity1.69760152
35MP0003123_paternal_imprinting1.66236495
36MP0010030_abnormal_orbit_morphology1.64204392
37MP0001545_abnormal_hematopoietic_system1.63075068
38MP0005397_hematopoietic_system_phenotyp1.63075068
39MP0010234_abnormal_vibrissa_follicle1.62807966
40MP0000490_abnormal_crypts_of1.62391781
41MP0000537_abnormal_urethra_morphology1.59736102
42MP0002420_abnormal_adaptive_immunity1.59025691
43MP0001819_abnormal_immune_cell1.58033550
44MP0005023_abnormal_wound_healing1.56105134
45MP0001800_abnormal_humoral_immune1.55776549
46MP0001697_abnormal_embryo_size1.55076721
47MP0001672_abnormal_embryogenesis/_devel1.54596119
48MP0005380_embryogenesis_phenotype1.54596119
49MP0002086_abnormal_extraembryonic_tissu1.54464027
50MP0002452_abnormal_antigen_presenting1.54022950
51MP0002877_abnormal_melanocyte_morpholog1.52593588
52MP0003984_embryonic_growth_retardation1.50751637
53MP0002723_abnormal_immune_serum1.50141811
54MP0002088_abnormal_embryonic_growth/wei1.49003971
55MP0002080_prenatal_lethality1.48362934
56MP0002084_abnormal_developmental_patter1.48261959
57MP0009053_abnormal_anal_canal1.46081083
58MP0002085_abnormal_embryonic_tissue1.45847664
59MP0001790_abnormal_immune_system1.44610758
60MP0005387_immune_system_phenotype1.44610758
61MP0003303_peritoneal_inflammation1.42454701
62MP0008057_abnormal_DNA_replication1.41058700
63MP0000716_abnormal_immune_system1.40842940
64MP0002148_abnormal_hypersensitivity_rea1.36333515
65MP0005671_abnormal_response_to1.35655325
66MP0003567_abnormal_fetal_cardiomyocyte1.33236346
67MP0004264_abnormal_extraembryonic_tissu1.32296644
68MP0001853_heart_inflammation1.31696110
69MP0002019_abnormal_tumor_incidence1.30748464
70MP0003866_abnormal_defecation1.29732431
71MP0000678_abnormal_parathyroid_gland1.29388192
72MP0004185_abnormal_adipocyte_glucose1.25317745
73MP0001533_abnormal_skeleton_physiology1.24992443
74MP0001915_intracranial_hemorrhage1.24424398
75MP0000858_altered_metastatic_potential1.23117281
76MP0009333_abnormal_splenocyte_physiolog1.21752674
77MP0008932_abnormal_embryonic_tissue1.21344013
78MP0002653_abnormal_ependyma_morphology1.18260209
79MP0002405_respiratory_system_inflammati1.17650580
80MP0003806_abnormal_nucleotide_metabolis1.16406960
81MP0000685_abnormal_immune_system1.15964518
82MP0001873_stomach_inflammation1.15728997
83MP0009785_altered_susceptibility_to1.14691700
84MP0002796_impaired_skin_barrier1.13975421
85MP0000703_abnormal_thymus_morphology1.12697608
86MP0004510_myositis1.09492166
87MP0005623_abnormal_meninges_morphology1.08404312
88MP0000313_abnormal_cell_death1.06798847
89MP0003724_increased_susceptibility_to1.05171307
90MP0003075_altered_response_to1.04850175
91MP0002398_abnormal_bone_marrow1.04690455
92MP0003115_abnormal_respiratory_system1.02529988
93MP0001845_abnormal_inflammatory_respons1.01316781
94MP0003091_abnormal_cell_migration1.01123230
95MP0002998_abnormal_bone_remodeling1.00352254
96MP0002722_abnormal_immune_system0.98984944
97MP0003763_abnormal_thymus_physiology0.98798194
98MP0000428_abnormal_craniofacial_morphol0.98660163
99MP0003329_amyloid_beta_deposits0.96336127
100MP0002925_abnormal_cardiovascular_devel0.95787394
101MP0000477_abnormal_intestine_morphology0.93888976
102MP0000681_abnormal_thyroid_gland0.91889921
103MP0009672_abnormal_birth_weight0.90706739
104MP0010630_abnormal_cardiac_muscle0.90029093
105MP0008469_abnormal_protein_level0.89816217
106MP0003119_abnormal_digestive_system0.89774456
107MP0005275_abnormal_skin_tensile0.89512261
108MP0000003_abnormal_adipose_tissue0.89375496
109MP0009840_abnormal_foam_cell0.89282501
110MP0008770_decreased_survivor_rate0.88715712
111MP0000689_abnormal_spleen_morphology0.88360647
112MP0000750_abnormal_muscle_regeneration0.88258750
113MP0003183_abnormal_peptide_metabolism0.88192771
114MP0005375_adipose_tissue_phenotype0.87912217
115MP0001958_emphysema0.87753813
116MP0003279_aneurysm0.87236758
117MP0004233_abnormal_muscle_weight0.86848808
118MP0001348_abnormal_lacrimal_gland0.86773376
119MP0000604_amyloidosis0.86182792
120MP0004272_abnormal_basement_membrane0.85725106
121MP0009931_abnormal_skin_appearance0.84584423
122MP0002089_abnormal_postnatal_growth/wei0.82529153
123MP0002111_abnormal_tail_morphology0.82268759
124MP0002092_abnormal_eye_morphology0.82213305
125MP0008961_abnormal_basal_metabolism0.81889983
126MP0003448_altered_tumor_morphology0.81476501
127MP0005621_abnormal_cell_physiology0.81386570
128MP0001851_eye_inflammation0.81337214
129MP0005257_abnormal_intraocular_pressure0.81130071
130MP0006082_CNS_inflammation0.80555694
131MP0003453_abnormal_keratinocyte_physiol0.79392621
132MP0002166_altered_tumor_susceptibility0.79137721
133MP0002429_abnormal_blood_cell0.78974249
134MP0000266_abnormal_heart_morphology0.77434590
135MP0005501_abnormal_skin_physiology0.77186153
136MP0004947_skin_inflammation0.76497920
137MP0003221_abnormal_cardiomyocyte_apopto0.76293083
138MP0002697_abnormal_eye_size0.74330679
139MP0003283_abnormal_digestive_organ0.74259363
140MP0001216_abnormal_epidermal_layer0.72882871
141MP0003656_abnormal_erythrocyte_physiolo0.72553499
142MP0000343_altered_response_to0.72411945
143MP0002132_abnormal_respiratory_system0.72345512
144MP0009703_decreased_birth_body0.71670290
145MP0005666_abnormal_adipose_tissue0.69771911
146MP0008058_abnormal_DNA_repair0.69546439
147MP0002932_abnormal_joint_morphology0.69495041
148MP0001614_abnormal_blood_vessel0.69050349
149MP0000465_gastrointestinal_hemorrhage0.68098812
150MP0004087_abnormal_muscle_fiber0.68094573
151MP0010155_abnormal_intestine_physiology0.67787220

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.84834854
2Hyperacusis (HP:0010780)3.47926159
3Cerebral aneurysm (HP:0004944)3.24053026
4Eczematoid dermatitis (HP:0000976)3.21482584
5Ependymoma (HP:0002888)3.17766206
6Ankle contracture (HP:0006466)3.03551416
7Centrally nucleated skeletal muscle fibers (HP:0003687)3.03480103
8Selective tooth agenesis (HP:0001592)2.96820311
9Vertebral compression fractures (HP:0002953)2.95317237
10Distal lower limb amyotrophy (HP:0008944)2.89385733
11Shallow orbits (HP:0000586)2.82928945
12Increased IgE level (HP:0003212)2.76589914
13Ragged-red muscle fibers (HP:0003200)2.72123535
14Abnormality of macrophages (HP:0004311)2.69412367
15Renal duplication (HP:0000075)2.67888502
16Ulnar bowing (HP:0003031)2.65628787
17Increased density of long bones (HP:0006392)2.64220350
18Chronic obstructive pulmonary disease (HP:0006510)2.61584077
19Obstructive lung disease (HP:0006536)2.61584077
20Short 4th metacarpal (HP:0010044)2.61336646
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.61336646
22Rectal prolapse (HP:0002035)2.61170417
23Hemorrhage of the eye (HP:0011885)2.58485891
24Mediastinal lymphadenopathy (HP:0100721)2.51942016
25Hypertensive crisis (HP:0100735)2.51751484
26Genu recurvatum (HP:0002816)2.48336352
27Abnormality of the astrocytes (HP:0100707)2.48010934
28Astrocytoma (HP:0009592)2.48010934
29Bladder diverticulum (HP:0000015)2.46994166
30Increased nuchal translucency (HP:0010880)2.42244450
31Elevated erythrocyte sedimentation rate (HP:0003565)2.41910238
32Purpura (HP:0000979)2.41711203
33Bowel diverticulosis (HP:0005222)2.39790857
34Recurrent abscess formation (HP:0002722)2.39275918
35Premature rupture of membranes (HP:0001788)2.37727982
36Renovascular hypertension (HP:0100817)2.37062639
37Basal cell carcinoma (HP:0002671)2.36998921
38Distal lower limb muscle weakness (HP:0009053)2.34745128
39Increased cerebral lipofuscin (HP:0011813)2.32556016
40High pitched voice (HP:0001620)2.30377314
41Insomnia (HP:0100785)2.29065957
42Dysostosis multiplex (HP:0000943)2.28687251
43Cholecystitis (HP:0001082)2.28229465
44Abnormal gallbladder physiology (HP:0012438)2.28229465
45Mitral valve prolapse (HP:0001634)2.26936961
46Gastrointestinal inflammation (HP:0004386)2.26803748
47Long palpebral fissure (HP:0000637)2.25024007
48Recurrent bacterial skin infections (HP:0005406)2.24694838
49Spastic diplegia (HP:0001264)2.23464417
50Abnormality of the calcaneus (HP:0008364)2.23059386
51Elfin facies (HP:0004428)2.22866935
52Abnormality of the 4th metacarpal (HP:0010012)2.21748678
53Abnormality of cells of the erythroid lineage (HP:0012130)2.21480778
54Recurrent viral infections (HP:0004429)2.19592251
55Broad face (HP:0000283)2.19512618
56Colitis (HP:0002583)2.19373706
57Reticulocytopenia (HP:0001896)2.18763049
58Colon cancer (HP:0003003)2.18710467
59Myopathic facies (HP:0002058)2.18131577
60Multiple enchondromatosis (HP:0005701)2.15435847
61Distal upper limb amyotrophy (HP:0007149)2.14623621
62Upper limb amyotrophy (HP:0009129)2.14623621
63Petechiae (HP:0000967)2.14279467
64Thrombocytosis (HP:0001894)2.14241867
65Hand muscle atrophy (HP:0009130)2.13790975
66Polygenic inheritance (HP:0010982)2.12727601
67Dilatation of the ascending aorta (HP:0005111)2.12156711
68Overriding aorta (HP:0002623)2.11056278
69Agammaglobulinemia (HP:0004432)2.11041494
70Abnormality of glycolipid metabolism (HP:0010969)2.11027668
71Abnormality of liposaccharide metabolism (HP:0010968)2.11027668
72Abnormality of glycosphingolipid metabolism (HP:0004343)2.11027668
73Thoracic kyphosis (HP:0002942)2.10994051
74Adenoma sebaceum (HP:0009720)2.09215605
75Angiofibromas (HP:0010615)2.09215605
76Aneurysm (HP:0002617)2.07904403
77Flat acetabular roof (HP:0003180)2.07838612
78Deviation of the thumb (HP:0009603)2.06647239
79Back pain (HP:0003418)2.06523959
80Abnormality of the peritoneum (HP:0002585)2.04599239
81Achilles tendon contracture (HP:0001771)2.04323876
82Abnormality of the thoracic spine (HP:0100711)2.04029518
83Broad palm (HP:0001169)2.03792167
84Pseudobulbar signs (HP:0002200)2.03328802
85Hepatosplenomegaly (HP:0001433)2.03077348
86Broad distal phalanx of finger (HP:0009836)2.02302102
87Proximal placement of thumb (HP:0009623)2.02210572
88Increased neuronal autofluorescent lipopigment (HP:0002074)2.02191942
89Abnormal number of erythroid precursors (HP:0012131)2.00429901
90Hypertriglyceridemia (HP:0002155)1.99622500
91Meningitis (HP:0001287)1.99034193
92Hallux valgus (HP:0001822)1.98576716
93Lymphangioma (HP:0100764)1.98243343
94Gastrointestinal dysmotility (HP:0002579)1.97979127
95Gastrointestinal stroma tumor (HP:0100723)1.96727765
96Deviation of the hallux (HP:0010051)1.96436384
97Radial bowing (HP:0002986)1.96061663
98Subacute progressive viral hepatitis (HP:0006572)1.95350755
99Aortic aneurysm (HP:0004942)1.95153991
100Fibroma (HP:0010614)1.92346108
101Bowed forearm bones (HP:0003956)1.91843212
102Bowing of the arm (HP:0006488)1.91843212
103Systemic lupus erythematosus (HP:0002725)1.90949954
104Abnormality of reticulocytes (HP:0004312)1.90177320
105Inflammation of the large intestine (HP:0002037)1.90132983
106Medulloblastoma (HP:0002885)1.88180750
107Bicuspid aortic valve (HP:0001647)1.87130080
108Abnormality of the Achilles tendon (HP:0005109)1.87111018
109Increased IgM level (HP:0003496)1.85935308
110Flattened epiphyses (HP:0003071)1.85779003
111Recurrent fungal infections (HP:0002841)1.85753746
112Increased connective tissue (HP:0009025)1.85334342
113Fibrous tissue neoplasm (HP:0012316)1.85225842
114Gastrointestinal carcinoma (HP:0002672)1.85006085
115Malignant gastrointestinal tract tumors (HP:0006749)1.85006085
116Peritonitis (HP:0002586)1.83563091
117Interstitial pulmonary disease (HP:0006530)1.83453665
118Prolonged bleeding time (HP:0003010)1.82904529
119Cutaneous melanoma (HP:0012056)1.82813215
120Deep venous thrombosis (HP:0002625)1.82519163
121Increased serum ferritin (HP:0003281)1.82117680
122Emphysema (HP:0002097)1.81347637
123Missing ribs (HP:0000921)1.80609182
124Abnormality of the nasal mucosa (HP:0000433)1.79829922
125Pointed chin (HP:0000307)1.79415961
126Myositis (HP:0100614)1.79334933
127Segmental peripheral demyelination/remyelination (HP:0003481)1.78124426
128Thin bony cortex (HP:0002753)1.77041373
129Cervical subluxation (HP:0003308)1.76799075
130Fatigue (HP:0012378)1.76752984
131Gingivitis (HP:0000230)1.76562285
132Seborrheic dermatitis (HP:0001051)1.76341898
133Disproportionate tall stature (HP:0001519)1.75931992
134Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.75872594
135Flat cornea (HP:0007720)1.75613835
136Progressive muscle weakness (HP:0003323)1.75404148
137Growth hormone excess (HP:0000845)1.74110012
138Reticulocytosis (HP:0001923)1.74097847
139Abnormality of skeletal muscle fiber size (HP:0012084)1.73751440
140Loss of speech (HP:0002371)1.73327714
141Enlarged penis (HP:0000040)1.73101073
142Epistaxis (HP:0000421)1.72512897
143Wrist flexion contracture (HP:0001239)1.72226667
144Abnormality of the fingertips (HP:0001211)1.71756777
145Trismus (HP:0000211)1.71220629
146Easy fatigability (HP:0003388)1.71095482
147Neoplasm of striated muscle (HP:0009728)1.71027085
148Hyperparathyroidism (HP:0000843)1.70702951
149Hypergammaglobulinemia (HP:0010702)1.70354994
150Glioma (HP:0009733)1.70087598
151Difficulty climbing stairs (HP:0003551)1.69723415
152Bone pain (HP:0002653)1.69491282
153Aortic dissection (HP:0002647)1.69057781
154Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.68999759
155Heterotopia (HP:0002282)1.67798252
156Polycythemia (HP:0001901)1.67388517
157Lower limb amyotrophy (HP:0007210)1.67275339
158Neuronal loss in central nervous system (HP:0002529)1.67175760
159Skin tags (HP:0010609)1.66836718
160Aplasia/Hypoplasia of the thymus (HP:0010515)1.66629946
161Slender long bone (HP:0003100)1.66030002
162Urticaria (HP:0001025)1.65226954
163Intestinal polyp (HP:0005266)1.65170499
164Granulocytopenia (HP:0001913)1.64495174
165Metaphyseal cupping (HP:0003021)1.64087652
166Rhabdomyosarcoma (HP:0002859)1.63309552
167Rough bone trabeculation (HP:0100670)1.62629565
168Nasal polyposis (HP:0100582)1.62474603
169Neoplasm of the pancreas (HP:0002894)1.62239954
170Increased mean platelet volume (HP:0011877)1.61035721
171Abnormal platelet volume (HP:0011876)1.60408571
172Megalocornea (HP:0000485)1.59871744
173Axonal loss (HP:0003447)1.59100682
174Elbow flexion contracture (HP:0002987)1.57610336
175Short 5th finger (HP:0009237)1.56926072
176Abnormality of oral frenula (HP:0000190)1.56877179
177Abnormal number of incisors (HP:0011064)1.56649248
178Bulbar palsy (HP:0001283)1.56067581
179Biliary tract neoplasm (HP:0100574)1.55957213
180Cellulitis (HP:0100658)1.55897353
181Broad metatarsal (HP:0001783)1.55782716
182Intestinal polyposis (HP:0200008)1.55387673

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.58679324
2TRIB34.31285698
3PKN24.08158687
4MAP3K103.56166851
5SMG13.07998491
6PRPF4B2.72885108
7CDK122.54930714
8CDC72.51948388
9IRAK32.37016207
10NEK22.33101843
11SCYL22.01005746
12RPS6KB21.97510079
13LRRK21.85812391
14TTN1.82620351
15PAK41.70416584
16ERN11.70278373
17NEK11.70141575
18RPS6KA41.68583961
19PTK61.62463421
20MAP3K131.59263405
21STK101.56372661
22MAP4K11.55295479
23CDK41.53549077
24FLT31.50922888
25WEE11.50285475
26TAOK21.49721688
27PDGFRA1.46566873
28ARAF1.45294337
29TGFBR11.42086144
30VRK21.40331013
31ICK1.35848818
32MAP3K81.34828110
33PASK1.31535402
34RIPK11.29237585
35CDK61.26308155
36BUB11.26185881
37BMX1.24950902
38ALK1.18054963
39NME21.15501335
40TESK21.15356724
41RIPK41.15197975
42IRAK41.14471613
43MAP2K31.12149592
44TTK1.09744332
45CDK71.06718701
46SIK11.06582749
47MTOR1.05191260
48MAPKAPK31.05147628
49GRK61.04449165
50MAP3K141.03680305
51MAP3K10.99422523
52BCKDK0.98714169
53PAK20.96613147
54PRKD20.96403917
55EPHA20.95472579
56TAOK10.90425392
57MAP3K110.89281829
58ILK0.89132922
59LATS10.88219788
60AURKB0.86287882
61ACVR1B0.82535271
62PIM10.79885479
63ATR0.78459481
64STK40.78167645
65CDC42BPA0.76960668
66LMTK20.76874974
67LIMK10.76041631
68TSSK60.75930670
69DYRK30.74195918
70FGFR40.74106987
71PLK10.74006196
72TYRO30.73077736
73DDR20.71582472
74MARK20.71016493
75LATS20.70611190
76* CHEK10.68511312
77ZAP700.67455137
78BRAF0.67087392
79CSK0.64611289
80MOS0.63721421
81IKBKE0.63425355
82STK30.63276415
83IRAK20.63268335
84BLK0.62877006
85HIPK20.61535078
86RPS6KL10.61324384
87RPS6KC10.61324384
88MAPK110.59181914
89PTK20.58711820
90RPS6KA20.57395342
91RET0.57118900
92PDPK10.56885955
93BRSK10.56861332
94KDR0.56546023
95TYK20.56356044
96KSR20.56264429
97SIK30.55274542
98JAK30.54984376
99CSF1R0.53948908
100AKT20.53895151
101BTK0.53748080
102CHEK20.53518726
103* CDK20.52578757
104CAMK1D0.52212560
105TESK10.51919454
106DAPK10.50605150
107MAP3K70.49719220
108FGFR10.49652533
109FES0.49201007
110HCK0.49105820
111MATK0.49073148
112PDGFRB0.49012993
113MST1R0.48997097
114DYRK1B0.48624380
115SYK0.47070664
116MELK0.46714473
117PAK10.46527900
118CLK10.46477410
119CDK80.45750488
120CDK90.45412452
121RPS6KA10.44456557
122TGFBR20.43191975
123BRD40.42784310
124EIF2AK10.42596615
125ABL20.41940649
126EPHB10.41667388
127AURKA0.41284530
128TBK10.40508561
129ATM0.40243185
130FGR0.39964538
131SIK20.39720431
132PRKD30.39617155
133IKBKB0.39324262
134RPS6KA60.39254829
135CDK11A0.39011270
136LCK0.38555914
137MAP3K30.34657684
138MAP2K20.34644294
139DMPK0.33586068
140BRSK20.32956071
141MAPKAPK20.31430072
142PIM20.29258265
143ITK0.28508031

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.73543757
2Other glycan degradation_Homo sapiens_hsa005112.72901472
3Mismatch repair_Homo sapiens_hsa034302.71907413
4Spliceosome_Homo sapiens_hsa030402.36248486
5Cell cycle_Homo sapiens_hsa041102.34938577
6One carbon pool by folate_Homo sapiens_hsa006702.30998354
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.18321784
8Base excision repair_Homo sapiens_hsa034102.16093314
9RNA transport_Homo sapiens_hsa030132.10663752
10Chronic myeloid leukemia_Homo sapiens_hsa052201.96938221
11Fructose and mannose metabolism_Homo sapiens_hsa000511.93668186
12Ribosome_Homo sapiens_hsa030101.80324324
13Small cell lung cancer_Homo sapiens_hsa052221.70558015
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69889871
15Bladder cancer_Homo sapiens_hsa052191.58092968
16Nucleotide excision repair_Homo sapiens_hsa034201.52542008
17p53 signaling pathway_Homo sapiens_hsa041151.49869738
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49423066
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48161858
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.46685994
21mRNA surveillance pathway_Homo sapiens_hsa030151.46022938
22Viral carcinogenesis_Homo sapiens_hsa052031.45737115
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37639689
24MicroRNAs in cancer_Homo sapiens_hsa052061.37393643
25Galactose metabolism_Homo sapiens_hsa000521.36020335
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.32659944
27Systemic lupus erythematosus_Homo sapiens_hsa053221.31485364
28HTLV-I infection_Homo sapiens_hsa051661.29258540
29Non-small cell lung cancer_Homo sapiens_hsa052231.27903882
30mTOR signaling pathway_Homo sapiens_hsa041501.27758643
31Thyroid cancer_Homo sapiens_hsa052161.27247326
32Notch signaling pathway_Homo sapiens_hsa043301.26281250
33Colorectal cancer_Homo sapiens_hsa052101.24186695
34Antigen processing and presentation_Homo sapiens_hsa046121.24018162
35Acute myeloid leukemia_Homo sapiens_hsa052211.23877046
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23606164
37Biosynthesis of amino acids_Homo sapiens_hsa012301.23066318
38Pancreatic cancer_Homo sapiens_hsa052121.19336636
39Salmonella infection_Homo sapiens_hsa051321.17879949
40Proteoglycans in cancer_Homo sapiens_hsa052051.17007569
41Influenza A_Homo sapiens_hsa051641.16099156
42Lysosome_Homo sapiens_hsa041421.13529960
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12248557
44Lysine degradation_Homo sapiens_hsa003101.10051264
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07799506
46Adherens junction_Homo sapiens_hsa045201.06465340
47Prion diseases_Homo sapiens_hsa050201.06355246
48Homologous recombination_Homo sapiens_hsa034401.06057996
49Allograft rejection_Homo sapiens_hsa053301.05911247
50Tuberculosis_Homo sapiens_hsa051521.05116335
51Apoptosis_Homo sapiens_hsa042101.04242576
52Focal adhesion_Homo sapiens_hsa045101.03699200
53Hepatitis C_Homo sapiens_hsa051601.02086986
54Herpes simplex infection_Homo sapiens_hsa051681.01479952
55Endometrial cancer_Homo sapiens_hsa052130.98572263
56Pentose phosphate pathway_Homo sapiens_hsa000300.97092930
57Shigellosis_Homo sapiens_hsa051310.96626130
58Hippo signaling pathway_Homo sapiens_hsa043900.96595679
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96507021
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96306619
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95314109
62Selenocompound metabolism_Homo sapiens_hsa004500.95267207
63Autoimmune thyroid disease_Homo sapiens_hsa053200.94473148
64TNF signaling pathway_Homo sapiens_hsa046680.93900815
65VEGF signaling pathway_Homo sapiens_hsa043700.93514185
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.93459130
67Viral myocarditis_Homo sapiens_hsa054160.92220660
68Hepatitis B_Homo sapiens_hsa051610.91725919
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91010181
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90700299
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.89898572
72Basal cell carcinoma_Homo sapiens_hsa052170.89393981
73Endocytosis_Homo sapiens_hsa041440.89319623
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88840715
75B cell receptor signaling pathway_Homo sapiens_hsa046620.87375115
76Graft-versus-host disease_Homo sapiens_hsa053320.87314868
77Sulfur relay system_Homo sapiens_hsa041220.87246884
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.86017956
79Staphylococcus aureus infection_Homo sapiens_hsa051500.85345722
80Epstein-Barr virus infection_Homo sapiens_hsa051690.85203180
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84785478
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.83881505
83Toxoplasmosis_Homo sapiens_hsa051450.83271846
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81942715
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81347774
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81186000
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81135790
88ECM-receptor interaction_Homo sapiens_hsa045120.80563027
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80278305
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79033299
91Primary immunodeficiency_Homo sapiens_hsa053400.78250423
92HIF-1 signaling pathway_Homo sapiens_hsa040660.77441193
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77402121
94Glioma_Homo sapiens_hsa052140.75726292
95RNA degradation_Homo sapiens_hsa030180.75397176
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.75233677
97Carbon metabolism_Homo sapiens_hsa012000.74671739
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73705516
99TGF-beta signaling pathway_Homo sapiens_hsa043500.73592552
100Vibrio cholerae infection_Homo sapiens_hsa051100.73508926
101N-Glycan biosynthesis_Homo sapiens_hsa005100.71739758
102Hematopoietic cell lineage_Homo sapiens_hsa046400.70172216
103Pertussis_Homo sapiens_hsa051330.70074914
104Phagosome_Homo sapiens_hsa041450.69956348
105Pathways in cancer_Homo sapiens_hsa052000.68915214
106Amoebiasis_Homo sapiens_hsa051460.68043301
107Pyrimidine metabolism_Homo sapiens_hsa002400.67103170
108Prostate cancer_Homo sapiens_hsa052150.66405229
109Platelet activation_Homo sapiens_hsa046110.65006223
110Insulin resistance_Homo sapiens_hsa049310.63736134
111Leishmaniasis_Homo sapiens_hsa051400.63010952
112Legionellosis_Homo sapiens_hsa051340.62471028
113Malaria_Homo sapiens_hsa051440.62312997
114AMPK signaling pathway_Homo sapiens_hsa041520.61918167
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61643535
116Chemokine signaling pathway_Homo sapiens_hsa040620.60409855
117Measles_Homo sapiens_hsa051620.60091660
118Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59631706
119Non-homologous end-joining_Homo sapiens_hsa034500.58313026
120Oocyte meiosis_Homo sapiens_hsa041140.58256789
121Renal cell carcinoma_Homo sapiens_hsa052110.57310301
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56462823
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56248780
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56120350
125Insulin signaling pathway_Homo sapiens_hsa049100.56048653
126Asthma_Homo sapiens_hsa053100.55904292
127T cell receptor signaling pathway_Homo sapiens_hsa046600.54357495
128Fanconi anemia pathway_Homo sapiens_hsa034600.53891110
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.53689291
130Osteoclast differentiation_Homo sapiens_hsa043800.53664130
131Prolactin signaling pathway_Homo sapiens_hsa049170.51824142
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50716666
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50258703
134FoxO signaling pathway_Homo sapiens_hsa040680.49898725
135ErbB signaling pathway_Homo sapiens_hsa040120.46535953
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46017077
137NF-kappa B signaling pathway_Homo sapiens_hsa040640.45968295

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