RALYL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.61489604
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.58964098
3vocalization behavior (GO:0071625)5.55666498
4neuron cell-cell adhesion (GO:0007158)5.50702928
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.25810168
6protein localization to synapse (GO:0035418)5.12158511
7glutamate secretion (GO:0014047)4.93138959
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.88793552
9ionotropic glutamate receptor signaling pathway (GO:0035235)4.87799524
10regulation of glutamate receptor signaling pathway (GO:1900449)4.81816917
11regulation of synaptic vesicle exocytosis (GO:2000300)4.73714943
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.68974336
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.58836113
14neuronal action potential propagation (GO:0019227)4.53785683
15glutamate receptor signaling pathway (GO:0007215)4.50465460
16pyrimidine nucleobase catabolic process (GO:0006208)4.49045317
17synaptic vesicle maturation (GO:0016188)4.41217284
18presynaptic membrane assembly (GO:0097105)4.32104411
19neuron recognition (GO:0008038)4.27978415
20locomotory exploration behavior (GO:0035641)4.27490605
21auditory behavior (GO:0031223)4.27314773
22regulation of synaptic vesicle transport (GO:1902803)4.25428600
23neurotransmitter secretion (GO:0007269)4.22304099
24synaptic transmission, glutamatergic (GO:0035249)4.22009365
25neuron-neuron synaptic transmission (GO:0007270)4.19826186
26synaptic vesicle docking involved in exocytosis (GO:0016081)4.15841423
27exploration behavior (GO:0035640)4.12412159
28gamma-aminobutyric acid signaling pathway (GO:0007214)4.05370637
29presynaptic membrane organization (GO:0097090)4.04006436
30neurotransmitter-gated ion channel clustering (GO:0072578)3.99678242
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.98226341
32negative regulation of synaptic transmission, GABAergic (GO:0032229)3.96955306
33postsynaptic membrane organization (GO:0001941)3.89819062
34regulation of neuronal synaptic plasticity (GO:0048168)3.80239002
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.79211315
36nucleobase catabolic process (GO:0046113)3.78381581
37regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.74557947
38response to histamine (GO:0034776)3.73268189
39axonal fasciculation (GO:0007413)3.72629973
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71625828
41cellular potassium ion homeostasis (GO:0030007)3.70207306
42establishment of mitochondrion localization (GO:0051654)3.68447385
43regulation of postsynaptic membrane potential (GO:0060078)3.66717528
44response to auditory stimulus (GO:0010996)3.64368572
45neurotransmitter transport (GO:0006836)3.62622434
46neuronal ion channel clustering (GO:0045161)3.61117266
47proline transport (GO:0015824)3.58892278
48positive regulation of synapse assembly (GO:0051965)3.55743834
49layer formation in cerebral cortex (GO:0021819)3.55664733
50positive regulation of synapse maturation (GO:0090129)3.52294368
51long-term synaptic potentiation (GO:0060291)3.52059976
52regulation of synapse structural plasticity (GO:0051823)3.52044104
53startle response (GO:0001964)3.47199746
54transmission of nerve impulse (GO:0019226)3.42714955
55regulation of vesicle fusion (GO:0031338)3.42363995
56synaptic vesicle endocytosis (GO:0048488)3.42342599
57regulation of glutamate secretion (GO:0014048)3.41697848
58positive regulation of membrane potential (GO:0045838)3.37903835
59regulation of neurotransmitter levels (GO:0001505)3.36463459
60G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.35980082
61mechanosensory behavior (GO:0007638)3.35013564
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.34925842
63dendritic spine morphogenesis (GO:0060997)3.34376002
64regulation of synaptic plasticity (GO:0048167)3.33610605
65gamma-aminobutyric acid transport (GO:0015812)3.33209059
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.31642214
67long-term memory (GO:0007616)3.31502178
68negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.29557207
69behavioral defense response (GO:0002209)3.26488888
70behavioral fear response (GO:0001662)3.26488888
71positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.25826970
72dendrite morphogenesis (GO:0048813)3.25742284
73sodium ion export (GO:0071436)3.25377027
74regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.25100496
75cerebellar Purkinje cell differentiation (GO:0021702)3.21275812
76behavioral response to cocaine (GO:0048148)3.18611206
77synapse assembly (GO:0007416)3.18368352
78regulation of neurotransmitter secretion (GO:0046928)3.17774946
79cerebellar granule cell differentiation (GO:0021707)3.17194714
80positive regulation of dendritic spine development (GO:0060999)3.16421244
81membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.15136048
82positive regulation of neurotransmitter secretion (GO:0001956)3.15000497
83membrane depolarization (GO:0051899)3.13622269
84cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.12362550
85positive regulation of dendritic spine morphogenesis (GO:0061003)3.12027435
86regulation of synapse maturation (GO:0090128)3.10593056
87fear response (GO:0042596)3.09429507
88serotonin metabolic process (GO:0042428)3.09093628
89ATP hydrolysis coupled proton transport (GO:0015991)3.08158427
90energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.08158427
91regulation of dendritic spine morphogenesis (GO:0061001)3.07784049
92intraspecies interaction between organisms (GO:0051703)3.05471127
93social behavior (GO:0035176)3.05471127
94negative regulation of dendrite morphogenesis (GO:0050774)3.04914205
95positive regulation of neurotransmitter transport (GO:0051590)3.04184685
96innervation (GO:0060384)3.02802904
97synaptic vesicle transport (GO:0048489)3.01731966
98establishment of synaptic vesicle localization (GO:0097480)3.01731966
99cell migration in hindbrain (GO:0021535)3.01103262
100neuromuscular synaptic transmission (GO:0007274)3.01081694
101learning (GO:0007612)3.00443040
102synaptic transmission (GO:0007268)2.99676375
103membrane hyperpolarization (GO:0060081)2.99256763
104establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.98927826
105mitochondrion transport along microtubule (GO:0047497)2.98927826
106adult walking behavior (GO:0007628)2.98419611
107regulation of voltage-gated calcium channel activity (GO:1901385)2.96876388
108regulation of dendritic spine development (GO:0060998)2.96835126
109regulation of synapse assembly (GO:0051963)2.96774202
110central nervous system projection neuron axonogenesis (GO:0021952)2.95785821
111activation of protein kinase A activity (GO:0034199)2.95563081
112regulation of neurotransmitter transport (GO:0051588)2.95393795
113negative regulation of dendrite development (GO:2000171)2.95253266
114dendritic spine organization (GO:0097061)2.94403851
115neuromuscular process controlling posture (GO:0050884)2.94098110
116regulation of synaptic transmission, GABAergic (GO:0032228)2.91565110
117positive regulation of synaptic transmission (GO:0050806)2.90951527
118regulation of synaptic transmission (GO:0050804)2.90844300
119neurotransmitter uptake (GO:0001504)2.90160276
120regulation of protein kinase A signaling (GO:0010738)2.90053080
121cell communication by electrical coupling (GO:0010644)2.89475005
122positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.89143972
123regulation of respiratory system process (GO:0044065)2.89098048
124detection of calcium ion (GO:0005513)2.88972079
125membrane depolarization during action potential (GO:0086010)2.88656738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.39903245
2GBX2_23144817_ChIP-Seq_PC3_Human4.29046212
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18703278
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.08232024
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03367672
6TAF15_26573619_Chip-Seq_HEK293_Human2.70750865
7REST_21632747_ChIP-Seq_MESCs_Mouse2.68256850
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66684515
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58301379
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58301379
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.56995040
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56756469
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52288327
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50558253
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36650843
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35128952
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.32205064
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.30518924
19* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28026101
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20607315
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19529214
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.13809091
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11724487
24* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09915978
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.07905056
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04940378
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.04893433
28* RNF2_27304074_Chip-Seq_ESCs_Mouse2.01767962
29DROSHA_22980978_ChIP-Seq_HELA_Human1.93002617
30AR_21572438_ChIP-Seq_LNCaP_Human1.91337037
31SMAD4_21799915_ChIP-Seq_A2780_Human1.88376402
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87350696
33* P300_19829295_ChIP-Seq_ESCs_Human1.83103449
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81639266
35* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80202197
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77867065
37* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65288679
38FUS_26573619_Chip-Seq_HEK293_Human1.64369932
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63854773
40* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63560866
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63152774
42* CBX2_27304074_Chip-Seq_ESCs_Mouse1.61842026
43VDR_22108803_ChIP-Seq_LS180_Human1.61790354
44ZNF274_21170338_ChIP-Seq_K562_Hela1.61134117
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53396184
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.52704160
47* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49234767
48IGF1R_20145208_ChIP-Seq_DFB_Human1.49041004
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47942413
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46202126
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44027296
52* AR_25329375_ChIP-Seq_VCAP_Human1.42176399
53* PIAS1_25552417_ChIP-Seq_VCAP_Human1.40590342
54* RNF2_27304074_Chip-Seq_NSC_Mouse1.40523507
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38551021
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38307962
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37688995
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35076216
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35020841
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.32773908
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.31102819
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29613866
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29113245
64* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25658732
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24468200
66STAT3_23295773_ChIP-Seq_U87_Human1.23402993
67ER_23166858_ChIP-Seq_MCF-7_Human1.22491099
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.19297940
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.17838366
70JUN_21703547_ChIP-Seq_K562_Human1.16727508
71RUNX2_22187159_ChIP-Seq_PCA_Human1.13950221
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.12737463
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12565878
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12545580
75* TCF4_23295773_ChIP-Seq_U87_Human1.11359396
76* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11275566
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.11106934
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09977504
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09898448
80AR_19668381_ChIP-Seq_PC3_Human1.05947218
81BCAT_22108803_ChIP-Seq_LS180_Human1.05222719
82P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04407687
83* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04286426
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03879464
85RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03679458
86TP53_18474530_ChIP-ChIP_U2OS_Human1.03415290
87AHR_22903824_ChIP-Seq_MCF-7_Human1.03166165
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02908856
89* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02533088
90* NANOG_18555785_Chip-Seq_ESCs_Mouse1.02393195
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00918681
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00918681
93SOX9_26525672_Chip-Seq_HEART_Mouse1.00178423
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99282975
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98625485
96NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98380940
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97512415
98YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97003066
99* TAL1_26923725_Chip-Seq_HPCs_Mouse0.96987552
100FLI1_21867929_ChIP-Seq_TH2_Mouse0.96274614
101* EWS_26573619_Chip-Seq_HEK293_Human0.95730379
102RING1B_27294783_Chip-Seq_NPCs_Mouse0.95680193
103WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95534092
104* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95396630
105KDM2B_26808549_Chip-Seq_REH_Human0.94196094
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93763042
107ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93661226
108KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93639322
109FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91807348
110CBP_20019798_ChIP-Seq_JUKART_Human0.90296332
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90296332
112SMAD3_21741376_ChIP-Seq_ESCs_Human0.90012542
113TP53_16413492_ChIP-PET_HCT116_Human0.88198806
114E2F1_18555785_Chip-Seq_ESCs_Mouse0.87742261

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.63215163
2MP0004859_abnormal_synaptic_plasticity5.39192821
3MP0003635_abnormal_synaptic_transmissio3.97966582
4MP0004270_analgesia3.46304486
5MP0001968_abnormal_touch/_nociception3.44359809
6MP0009745_abnormal_behavioral_response3.38266125
7MP0002063_abnormal_learning/memory/cond3.24696087
8MP0002064_seizures3.16089688
9MP0009046_muscle_twitch3.09044147
10MP0002572_abnormal_emotion/affect_behav2.92322914
11MP0002736_abnormal_nociception_after2.87780749
12MP0006276_abnormal_autonomic_nervous2.86929801
13MP0002735_abnormal_chemical_nociception2.70355684
14MP0002272_abnormal_nervous_system2.60996615
15MP0002734_abnormal_mechanical_nocicepti2.58427173
16MP0001501_abnormal_sleep_pattern2.52295840
17MP0005423_abnormal_somatic_nervous2.48849817
18MP0001440_abnormal_grooming_behavior2.43534878
19MP0001486_abnormal_startle_reflex2.40383919
20MP0002733_abnormal_thermal_nociception2.22814743
21MP0002067_abnormal_sensory_capabilities2.14114163
22MP0001529_abnormal_vocalization2.08303965
23MP0002184_abnormal_innervation2.03722028
24MP0001970_abnormal_pain_threshold2.02827429
25MP0002822_catalepsy2.01122362
26MP0000778_abnormal_nervous_system1.97158705
27MP0003122_maternal_imprinting1.91157779
28MP0005386_behavior/neurological_phenoty1.86621973
29MP0004924_abnormal_behavior1.86621973
30MP0002557_abnormal_social/conspecific_i1.82551112
31MP0003329_amyloid_beta_deposits1.73358867
32MP0001905_abnormal_dopamine_level1.67382930
33MP0001984_abnormal_olfaction1.63905119
34MP0001188_hyperpigmentation1.61617970
35MP0003787_abnormal_imprinting1.58658299
36MP0005645_abnormal_hypothalamus_physiol1.58433364
37MP0004811_abnormal_neuron_physiology1.57275160
38MP0004142_abnormal_muscle_tone1.52305697
39MP0005646_abnormal_pituitary_gland1.49324938
40MP0003879_abnormal_hair_cell1.47112563
41MP0009780_abnormal_chondrocyte_physiolo1.46194228
42MP0008877_abnormal_DNA_methylation1.46178885
43MP0008569_lethality_at_weaning1.45856431
44MP0002837_dystrophic_cardiac_calcinosis1.45812070
45MP0000955_abnormal_spinal_cord1.45271753
46MP0002066_abnormal_motor_capabilities/c1.40740861
47MP0002882_abnormal_neuron_morphology1.39445121
48MP0000569_abnormal_digit_pigmentation1.39428743
49MP0004858_abnormal_nervous_system1.38401838
50MP0002909_abnormal_adrenal_gland1.33986115
51MP0001502_abnormal_circadian_rhythm1.27477733
52MP0004742_abnormal_vestibular_system1.11343206
53MP0000751_myopathy1.10980426
54MP0002876_abnormal_thyroid_physiology1.08544785
55MP0003690_abnormal_glial_cell1.07446862
56MP0003633_abnormal_nervous_system1.07329581
57MP0002152_abnormal_brain_morphology1.06756219
58MP0004147_increased_porphyrin_level1.05623151
59MP0004885_abnormal_endolymph0.96983753
60MP0003631_nervous_system_phenotype0.96795929
61MP0005551_abnormal_eye_electrophysiolog0.95657739
62MP0008872_abnormal_physiological_respon0.94713779
63MP0001963_abnormal_hearing_physiology0.93214704
64MP0002229_neurodegeneration0.92209922
65MP0004145_abnormal_muscle_electrophysio0.91970386
66MP0005535_abnormal_body_temperature0.91783488
67MP0002069_abnormal_eating/drinking_beha0.91456260
68MP0005499_abnormal_olfactory_system0.89194187
69MP0005394_taste/olfaction_phenotype0.89194187
70MP0002752_abnormal_somatic_nervous0.85861188
71MP0000631_abnormal_neuroendocrine_gland0.85772073
72MP0008874_decreased_physiological_sensi0.82784906
73MP0010386_abnormal_urinary_bladder0.82654699
74MP0004085_abnormal_heartbeat0.82444575
75MP0005253_abnormal_eye_physiology0.79254065
76MP0000920_abnormal_myelination0.77636598
77MP0005409_darkened_coat_color0.77336370
78MP0004484_altered_response_of0.76265114
79MP0001664_abnormal_digestion0.75863340
80MP0004215_abnormal_myocardial_fiber0.74523785
81MP0004043_abnormal_pH_regulation0.74516290
82MP0003121_genomic_imprinting0.72693756
83MP0000604_amyloidosis0.71792127
84MP0009379_abnormal_foot_pigmentation0.69199303
85MP0000013_abnormal_adipose_tissue0.68758575
86MP0003283_abnormal_digestive_organ0.68111717
87MP0000026_abnormal_inner_ear0.67070870
88MP0003634_abnormal_glial_cell0.66881324
89MP0002102_abnormal_ear_morphology0.66432233
90MP0003632_abnormal_nervous_system0.66044585
91MP0002751_abnormal_autonomic_nervous0.65656685
92MP0005187_abnormal_penis_morphology0.64416358
93MP0006292_abnormal_olfactory_placode0.63343904
94MP0005167_abnormal_blood-brain_barrier0.63016376
95MP0001943_abnormal_respiration0.61037355
96MP0004133_heterotaxia0.60123926
97MP0005171_absent_coat_pigmentation0.58815007
98MP0001485_abnormal_pinna_reflex0.57754980
99MP0002928_abnormal_bile_duct0.57748479
100MP0010768_mortality/aging0.57733964
101MP0001177_atelectasis0.57513111
102MP0003861_abnormal_nervous_system0.57178081
103MP0005623_abnormal_meninges_morphology0.56933153
104MP0006072_abnormal_retinal_apoptosis0.56617022
105MP0002638_abnormal_pupillary_reflex0.55003164
106MP0004233_abnormal_muscle_weight0.54912089
107MP0010770_preweaning_lethality0.51923162
108MP0002082_postnatal_lethality0.51923162
109MP0000639_abnormal_adrenal_gland0.51734608
110MP0002090_abnormal_vision0.50119472
111MP0010769_abnormal_survival0.50114883
112MP0003123_paternal_imprinting0.49990635
113MP0003137_abnormal_impulse_conducting0.49041821
114MP0006035_abnormal_mitochondrial_morpho0.48959830
115MP0003956_abnormal_body_size0.48109086

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.70590641
2Focal seizures (HP:0007359)5.72413356
3Myokymia (HP:0002411)5.50213048
4Atonic seizures (HP:0010819)5.43887841
5Epileptic encephalopathy (HP:0200134)5.03751663
6Visual hallucinations (HP:0002367)4.89081275
7Febrile seizures (HP:0002373)4.73077229
8Hyperventilation (HP:0002883)4.56740046
9Absence seizures (HP:0002121)4.55639590
10Dialeptic seizures (HP:0011146)4.19969131
11Progressive cerebellar ataxia (HP:0002073)4.19316686
12Generalized tonic-clonic seizures (HP:0002069)3.90380397
13Broad-based gait (HP:0002136)3.71503432
14Amblyopia (HP:0000646)3.39990840
15Truncal ataxia (HP:0002078)3.03943060
16Limb dystonia (HP:0002451)3.02757492
17Progressive inability to walk (HP:0002505)2.98892242
18Gaze-evoked nystagmus (HP:0000640)2.97554586
19Excessive salivation (HP:0003781)2.97413157
20Drooling (HP:0002307)2.97413157
21Supranuclear gaze palsy (HP:0000605)2.95409547
22Abnormal eating behavior (HP:0100738)2.94337881
23Impaired vibration sensation in the lower limbs (HP:0002166)2.93893529
24Anxiety (HP:0000739)2.91450640
25Action tremor (HP:0002345)2.90059986
26Polyphagia (HP:0002591)2.88293190
27Poor eye contact (HP:0000817)2.87132075
28Epileptiform EEG discharges (HP:0011182)2.80790637
29Gait imbalance (HP:0002141)2.67759630
30Pheochromocytoma (HP:0002666)2.65578652
31Inability to walk (HP:0002540)2.64618987
32Depression (HP:0000716)2.62573462
33Absent speech (HP:0001344)2.61923808
34Cerebral inclusion bodies (HP:0100314)2.61747922
35Impaired social interactions (HP:0000735)2.59545127
36Abnormal social behavior (HP:0012433)2.59545127
37EEG with generalized epileptiform discharges (HP:0011198)2.59117133
38Morphological abnormality of the pyramidal tract (HP:0002062)2.59065261
39Intention tremor (HP:0002080)2.58797112
40Ankle clonus (HP:0011448)2.58372386
41Dysdiadochokinesis (HP:0002075)2.57782394
42Acute necrotizing encephalopathy (HP:0006965)2.57079672
43Insidious onset (HP:0003587)2.55628449
44Termporal pattern (HP:0011008)2.55628449
45Urinary bladder sphincter dysfunction (HP:0002839)2.52102664
46Dysmetria (HP:0001310)2.50818433
47Mutism (HP:0002300)2.50779792
48Protruding tongue (HP:0010808)2.50137953
49Abnormal hair whorl (HP:0010721)2.48391077
50Progressive macrocephaly (HP:0004481)2.41536717
51Hypothermia (HP:0002045)2.41530564
52Hypsarrhythmia (HP:0002521)2.41326906
53Neuroendocrine neoplasm (HP:0100634)2.40299210
54Fetal akinesia sequence (HP:0001989)2.38957347
55Abnormality of binocular vision (HP:0011514)2.36854189
56Diplopia (HP:0000651)2.36854189
57Abnormal mitochondria in muscle tissue (HP:0008316)2.35804898
58Failure to thrive in infancy (HP:0001531)2.34643366
59Abnormality of the corticospinal tract (HP:0002492)2.34084310
60Lower limb muscle weakness (HP:0007340)2.33811760
61Spastic tetraplegia (HP:0002510)2.33292693
62Scanning speech (HP:0002168)2.32900843
63Urinary urgency (HP:0000012)2.30680269
64Poor suck (HP:0002033)2.29061540
65Medial flaring of the eyebrow (HP:0010747)2.27252245
66Sleep apnea (HP:0010535)2.25964009
67Congenital primary aphakia (HP:0007707)2.25045739
68Neurofibrillary tangles (HP:0002185)2.24717992
69Hemiparesis (HP:0001269)2.23812844
70Spastic gait (HP:0002064)2.23643976
71Muscular hypotonia of the trunk (HP:0008936)2.20037710
72Specific learning disability (HP:0001328)2.15119256
73Hemiplegia (HP:0002301)2.14048158
74Impaired smooth pursuit (HP:0007772)2.12697770
75Bradykinesia (HP:0002067)2.12088360
76Delusions (HP:0000746)2.11087825
77Postural instability (HP:0002172)2.10971728
78Generalized myoclonic seizures (HP:0002123)2.10608825
79Genetic anticipation (HP:0003743)2.07938008
80Psychosis (HP:0000709)2.07734234
81Hyperthyroidism (HP:0000836)2.07373723
82Nephrogenic diabetes insipidus (HP:0009806)2.07055265
83Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.06993036
84Abnormality of salivation (HP:0100755)2.06513970
85Blue irides (HP:0000635)2.04978687
86Hypoventilation (HP:0002791)2.04637257
87Esotropia (HP:0000565)2.04538242
88Status epilepticus (HP:0002133)2.03978341
89Lissencephaly (HP:0001339)2.03493263
90Stereotypic behavior (HP:0000733)2.01063393
91Mitochondrial inheritance (HP:0001427)1.97719000
92Torticollis (HP:0000473)1.97448689
93Genital tract atresia (HP:0001827)1.96843737
94Agitation (HP:0000713)1.96412914
95Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.95094031
96Degeneration of the lateral corticospinal tracts (HP:0002314)1.95094031
97Abnormality of the lower motor neuron (HP:0002366)1.95004768
98Focal dystonia (HP:0004373)1.93938722
99Akinesia (HP:0002304)1.93733908
100Abnormality of the labia minora (HP:0012880)1.92972984
101Narrow nasal bridge (HP:0000446)1.92853968
102Vaginal atresia (HP:0000148)1.92816429
103Papilledema (HP:0001085)1.91103392
104Aplasia/Hypoplasia of the brainstem (HP:0007362)1.90487269
105Hypoplasia of the brainstem (HP:0002365)1.90487269
106Impaired vibratory sensation (HP:0002495)1.89760897
107Hypoplasia of the corpus callosum (HP:0002079)1.89152849
108Dyskinesia (HP:0100660)1.88936090
109Incomplete penetrance (HP:0003829)1.88822266
110Exotropia (HP:0000577)1.87341176
111Retinal dysplasia (HP:0007973)1.86636296
112Amyotrophic lateral sclerosis (HP:0007354)1.85235097
113Craniofacial dystonia (HP:0012179)1.85117311
114Abnormality of ocular smooth pursuit (HP:0000617)1.84512187
115Diminished movement (HP:0002374)1.82747619
116Peripheral hypomyelination (HP:0007182)1.82430324
117Paraplegia (HP:0010550)1.78331072
118Methylmalonic acidemia (HP:0002912)1.75911507
119Syncope (HP:0001279)1.71928846

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.64600532
2EPHA43.72809349
3CASK3.70283292
4MAP3K43.42273967
5MAP3K93.33973292
6MAP3K123.29246496
7MAP2K73.17063018
8MARK13.08820706
9MINK12.56644859
10PNCK2.38264208
11FRK2.25504156
12PINK12.22537898
13MAP2K42.20383831
14RIPK42.14882643
15PLK21.98216844
16DAPK21.89309298
17CDK191.84189321
18ARAF1.81219880
19MAP4K21.77601916
20TNIK1.77093365
21NTRK21.73950095
22MAPK131.68664312
23DAPK11.68157094
24GRK51.65599838
25KSR11.63936520
26KSR21.55362368
27PAK61.55320659
28NTRK11.39512044
29CDK51.34049289
30PRKCG1.27007029
31SIK21.26572577
32CSNK1G11.24261096
33CAMK2A1.23805147
34PRPF4B1.21184512
35NME11.13127158
36OXSR11.11751359
37CSNK1A1L1.10693078
38FES1.10626813
39BMPR21.05289008
40UHMK11.01580062
41MAP3K130.99276496
42PTK2B0.98612083
43CAMK2B0.96805858
44CAMKK10.92003443
45SIK30.89022063
46GRK70.88793554
47CDK180.87109826
48CSNK1G20.86689178
49LATS20.86340864
50FGR0.86074078
51CDK140.85176250
52CAMKK20.83153444
53CCNB10.82218072
54AKT30.81725165
55CDK150.81188718
56ERBB30.80003466
57PHKG20.79217770
58PHKG10.79217770
59BCR0.73320633
60SGK2230.73184920
61SGK4940.73184920
62DYRK1A0.71165641
63RAF10.70818545
64CDK11A0.70027964
65PAK30.69990568
66TRIM280.68732199
67FGFR20.68701552
68WNK30.68639067
69STK380.68432798
70CAMK10.68124877
71PRKCE0.62759449
72SGK20.61996199
73BRAF0.60656650
74STK110.59215306
75CAMK40.58948476
76MAP3K20.58790643
77CAMK2D0.56936682
78ADRBK10.56162535
79SGK10.55555121
80INSRR0.55355045
81MAP3K60.53962606
82ADRBK20.53930210
83TAOK10.53791844
84BMPR1B0.53629661
85RET0.52495015
86CAMK2G0.52279988
87CSNK1G30.51709770
88FER0.50530924
89LIMK10.50276593
90PRKG10.49496697
91TYRO30.48264220
92SGK30.47986038
93CSNK1D0.47272596
94PRKCZ0.46427728
95PRKD30.44207569
96MAP2K10.43351308
97MAPKAPK50.42988440
98TSSK60.42667344
99TNK20.41886930
100CSNK1A10.41706270
101MARK20.41479940
102PRKAA10.41461923
103ROCK20.41412646
104GRK60.38828476
105MAP3K10.38357304
106MAPK100.38015937
107PRKCA0.37349944
108MAPK120.36679379
109PRKCH0.35833672
110STK390.35732214
111CSNK1E0.35675862
112PRKACA0.35343471
113CAMK1G0.34406348
114RPS6KA30.33834482
115PDK10.32869838
116MAP3K50.32761202
117PKN10.32529517
118PDK40.32367234
119PDK30.32367234
120FYN0.31449845
121DYRK20.31380766
122PDPK10.31166102
123LMTK20.30806390
124TESK10.29298884
125GRK10.29274074
126PRKCB0.27828062
127MAP2K60.26641517
128PRKACG0.25995965

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.36420082
2Synaptic vesicle cycle_Homo sapiens_hsa047213.60940648
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87908620
4Long-term potentiation_Homo sapiens_hsa047202.71407151
5GABAergic synapse_Homo sapiens_hsa047272.66062211
6Amphetamine addiction_Homo sapiens_hsa050312.59624677
7Circadian entrainment_Homo sapiens_hsa047132.56111109
8Glutamatergic synapse_Homo sapiens_hsa047242.51774159
9Collecting duct acid secretion_Homo sapiens_hsa049662.50233398
10Olfactory transduction_Homo sapiens_hsa047402.50058219
11Morphine addiction_Homo sapiens_hsa050322.47771250
12Dopaminergic synapse_Homo sapiens_hsa047282.26199584
13Taste transduction_Homo sapiens_hsa047422.14740521
14Oxidative phosphorylation_Homo sapiens_hsa001902.08488968
15Salivary secretion_Homo sapiens_hsa049702.07238502
16Serotonergic synapse_Homo sapiens_hsa047262.05786602
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.97549944
18Long-term depression_Homo sapiens_hsa047301.83801979
19Renin secretion_Homo sapiens_hsa049241.82403033
20Insulin secretion_Homo sapiens_hsa049111.78325428
21Cholinergic synapse_Homo sapiens_hsa047251.69630309
22Cocaine addiction_Homo sapiens_hsa050301.68338967
23Gastric acid secretion_Homo sapiens_hsa049711.64462067
24Alzheimers disease_Homo sapiens_hsa050101.61997161
25Calcium signaling pathway_Homo sapiens_hsa040201.61316662
26Parkinsons disease_Homo sapiens_hsa050121.57954900
27Vibrio cholerae infection_Homo sapiens_hsa051101.54406179
28Oxytocin signaling pathway_Homo sapiens_hsa049211.54274502
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51624093
30Cardiac muscle contraction_Homo sapiens_hsa042601.50395227
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48424996
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43211821
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40436824
34Gap junction_Homo sapiens_hsa045401.31366272
35GnRH signaling pathway_Homo sapiens_hsa049121.29554951
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20417939
37Axon guidance_Homo sapiens_hsa043601.20300738
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13545248
39Phototransduction_Homo sapiens_hsa047441.12740171
40Huntingtons disease_Homo sapiens_hsa050161.11226189
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09730097
42cAMP signaling pathway_Homo sapiens_hsa040241.06624851
43Estrogen signaling pathway_Homo sapiens_hsa049151.00485603
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97749643
45Melanogenesis_Homo sapiens_hsa049160.94756280
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93321165
47ErbB signaling pathway_Homo sapiens_hsa040120.91597299
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90468097
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.88143648
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86707626
51Glioma_Homo sapiens_hsa052140.86521188
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83103720
53Type II diabetes mellitus_Homo sapiens_hsa049300.81468823
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81376131
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.80590645
56Oocyte meiosis_Homo sapiens_hsa041140.78402312
57Regulation of autophagy_Homo sapiens_hsa041400.77285006
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68590566
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65317097
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65124827
61Pancreatic secretion_Homo sapiens_hsa049720.63856197
62Dorso-ventral axis formation_Homo sapiens_hsa043200.62817379
63MAPK signaling pathway_Homo sapiens_hsa040100.62438152
64Rheumatoid arthritis_Homo sapiens_hsa053230.59573357
65Thyroid hormone synthesis_Homo sapiens_hsa049180.59448025
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57529400
67Choline metabolism in cancer_Homo sapiens_hsa052310.57140556
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56628681
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56502543
70Alcoholism_Homo sapiens_hsa050340.52798345
71Ras signaling pathway_Homo sapiens_hsa040140.52306766
72Glucagon signaling pathway_Homo sapiens_hsa049220.51763763
73Dilated cardiomyopathy_Homo sapiens_hsa054140.51352363
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.50511041
75Bile secretion_Homo sapiens_hsa049760.48033193
76VEGF signaling pathway_Homo sapiens_hsa043700.47358275
77African trypanosomiasis_Homo sapiens_hsa051430.45153508
78Ether lipid metabolism_Homo sapiens_hsa005650.45080191
79Type I diabetes mellitus_Homo sapiens_hsa049400.44980831
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44706738
81Vitamin B6 metabolism_Homo sapiens_hsa007500.43567194
82Phagosome_Homo sapiens_hsa041450.42174392
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.42030647
84Protein export_Homo sapiens_hsa030600.39628075
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37894812
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37679283
87Prion diseases_Homo sapiens_hsa050200.37554884
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36858332
89Wnt signaling pathway_Homo sapiens_hsa043100.36854768
90Ovarian steroidogenesis_Homo sapiens_hsa049130.35715554
91Steroid biosynthesis_Homo sapiens_hsa001000.35483154
92Rap1 signaling pathway_Homo sapiens_hsa040150.34650426
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34198108
94Inositol phosphate metabolism_Homo sapiens_hsa005620.34110559
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33985986
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33878506
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.33553291
98ABC transporters_Homo sapiens_hsa020100.33152887
99AMPK signaling pathway_Homo sapiens_hsa041520.29398444
100Renal cell carcinoma_Homo sapiens_hsa052110.28354462
101Tryptophan metabolism_Homo sapiens_hsa003800.27581297
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27541089
103Insulin signaling pathway_Homo sapiens_hsa049100.27375438
104Butanoate metabolism_Homo sapiens_hsa006500.26040465
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25778687
106Circadian rhythm_Homo sapiens_hsa047100.25630157
107Mineral absorption_Homo sapiens_hsa049780.25532650
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25519498
109Nitrogen metabolism_Homo sapiens_hsa009100.25374881
110mTOR signaling pathway_Homo sapiens_hsa041500.24527891
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23827865
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22753367
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22175551
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21574855
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19703885
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.19083295
117Tight junction_Homo sapiens_hsa045300.18301102
118Endocytosis_Homo sapiens_hsa041440.18213765
119Colorectal cancer_Homo sapiens_hsa052100.16910199

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