RAMP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)6.62030955
2regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)6.62030955
3interferon-gamma production (GO:0032609)5.57350067
4tolerance induction (GO:0002507)5.37802527
5natural killer cell activation involved in immune response (GO:0002323)4.96383709
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.76389433
7regulation of MHC class I biosynthetic process (GO:0045343)4.73391555
8NIK/NF-kappaB signaling (GO:0038061)4.70949406
9regulation of fever generation (GO:0031620)4.68865287
10endothelial cell chemotaxis (GO:0035767)4.59720572
11complement activation, classical pathway (GO:0006958)4.52470128
12negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.46962172
13regulation of memory T cell differentiation (GO:0043380)4.35980427
14regulation of gamma-delta T cell differentiation (GO:0045586)4.31110774
15glomerular filtration (GO:0003094)4.30217165
16endothelium development (GO:0003158)4.29362136
17positive regulation of heat generation (GO:0031652)4.27935634
18complement activation (GO:0006956)4.15778784
19embryonic process involved in female pregnancy (GO:0060136)4.13723950
20regulation of interleukin-12 biosynthetic process (GO:0045075)4.10162631
21viral protein processing (GO:0019082)4.09216304
22response to muramyl dipeptide (GO:0032495)4.04908333
23mammary gland epithelial cell proliferation (GO:0033598)4.02465471
24renal filtration (GO:0097205)3.85772336
25angiogenesis involved in wound healing (GO:0060055)3.84121923
26positive regulation of prostaglandin secretion (GO:0032308)3.83465643
27regulation of gamma-delta T cell activation (GO:0046643)3.81905723
28protein activation cascade (GO:0072376)3.80291387
29triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.79489820
30triglyceride catabolic process (GO:0019433)3.79214569
31response to interleukin-15 (GO:0070672)3.78420288
32cellular response to interleukin-15 (GO:0071350)3.76013221
33surfactant homeostasis (GO:0043129)3.68227758
34morphogenesis of an endothelium (GO:0003159)3.65723216
35endothelial tube morphogenesis (GO:0061154)3.65723216
36cell migration involved in sprouting angiogenesis (GO:0002042)3.60773232
37regulation of prostaglandin secretion (GO:0032306)3.59850958
38regulation of heat generation (GO:0031650)3.57288860
39regulation of activation of Janus kinase activity (GO:0010533)3.55603231
40regulation of lipoprotein metabolic process (GO:0050746)3.54271944
41negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.50666554
42complement activation, alternative pathway (GO:0006957)3.50464365
43peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.49992867
44regulation of T cell tolerance induction (GO:0002664)3.48698417
45mature B cell differentiation involved in immune response (GO:0002313)3.48452159
46blood coagulation, intrinsic pathway (GO:0007597)3.47283328
47positive regulation of osteoclast differentiation (GO:0045672)3.44710438
48ethanol oxidation (GO:0006069)3.43592113
49regulation of endothelial cell differentiation (GO:0045601)3.42405753
50neutral lipid catabolic process (GO:0046461)3.41281265
51acylglycerol catabolic process (GO:0046464)3.41281265
52thymic T cell selection (GO:0045061)3.35972244
53NADH metabolic process (GO:0006734)3.35347464
54regulation of germinal center formation (GO:0002634)3.34045670
55negative regulation of cell killing (GO:0031342)3.33466225
56negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.33466225
57negative thymic T cell selection (GO:0045060)3.33431843
58regulation of integrin-mediated signaling pathway (GO:2001044)3.33159843
59cGMP-mediated signaling (GO:0019934)3.31209056
60CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.29306748
61T-helper cell differentiation (GO:0042093)3.29306748
62mesodermal cell differentiation (GO:0048333)3.24783218
63negative T cell selection (GO:0043383)3.24733994
64positive thymic T cell selection (GO:0045059)3.20450106
65monocyte chemotaxis (GO:0002548)3.20089328
66mucosal-associated lymphoid tissue development (GO:0048537)3.19920974
67Peyers patch development (GO:0048541)3.19920974
68extracellular fibril organization (GO:0043206)3.19604609
69myeloid dendritic cell differentiation (GO:0043011)3.18607903
70regulation of chronic inflammatory response (GO:0002676)3.18037467
71regulation of sequestering of triglyceride (GO:0010889)3.17001995
72regulation of RIG-I signaling pathway (GO:0039535)3.16980759
73cellular response to epinephrine stimulus (GO:0071872)3.15887275
74positive regulation of lipoprotein lipase activity (GO:0051006)3.15641530
75positive regulation of triglyceride lipase activity (GO:0061365)3.15641530
76negative regulation of bone resorption (GO:0045779)3.15552370
77cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.15054920
78low-density lipoprotein particle clearance (GO:0034383)3.13900605
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.13829175
80keratan sulfate catabolic process (GO:0042340)3.13619928
81negative regulation of platelet activation (GO:0010544)3.08522105
82blood vessel endothelial cell migration (GO:0043534)3.05751815
83T cell selection (GO:0045058)3.05561190
84positive regulation of bone resorption (GO:0045780)3.05427032
85positive regulation of bone remodeling (GO:0046852)3.05427032
86transcytosis (GO:0045056)3.04533869
87T cell activation involved in immune response (GO:0002286)3.03638763
88positive regulation of T-helper cell differentiation (GO:0045624)3.01822979
89endoderm formation (GO:0001706)3.01801824
90regulation of complement activation (GO:0030449)3.01041478
91protein kinase C signaling (GO:0070528)3.00182067
92positive regulation of gamma-delta T cell activation (GO:0046645)2.99341854
93lymph vessel development (GO:0001945)2.98135452
94natural killer cell activation (GO:0030101)2.94685140
95negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.93656327
96regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.92029775
97positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.92024768
98cAMP biosynthetic process (GO:0006171)2.91540911
99positive regulation of p38MAPK cascade (GO:1900745)2.90553835
100positive regulation of T-helper 1 type immune response (GO:0002827)2.90347234
101fibril organization (GO:0097435)2.90313687
102negative regulation of nitric oxide biosynthetic process (GO:0045019)2.88106386
103regulation of protein activation cascade (GO:2000257)2.87740408
104cellular response to nitric oxide (GO:0071732)2.87703099
105regulation of p38MAPK cascade (GO:1900744)2.86656631
106tumor necrosis factor-mediated signaling pathway (GO:0033209)2.86531844
107barbed-end actin filament capping (GO:0051016)2.84902987
108virion assembly (GO:0019068)2.84758334
109positive regulation of T cell differentiation in thymus (GO:0033089)2.83177980
110endocrine hormone secretion (GO:0060986)2.82978686
111regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.82896378
112bone resorption (GO:0045453)2.82551286
113protein localization to cell surface (GO:0034394)2.82186015
114cellular response to reactive nitrogen species (GO:1902170)2.81685272
115response to corticosterone (GO:0051412)2.81652814
116positive regulation of vasculogenesis (GO:2001214)2.80595178
117B cell proliferation (GO:0042100)2.80305321
118regulation of macrophage derived foam cell differentiation (GO:0010743)2.78596341
119alpha-beta T cell differentiation involved in immune response (GO:0002293)2.78423766
120alpha-beta T cell activation involved in immune response (GO:0002287)2.78423766
121T cell differentiation involved in immune response (GO:0002292)2.78423766
122mature B cell differentiation (GO:0002335)2.76595554
123positive regulation of protein kinase C signaling (GO:0090037)2.76522667
124ERK1 and ERK2 cascade (GO:0070371)2.76051719
125regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.75319583
126low-density lipoprotein particle remodeling (GO:0034374)2.74992979
127chemical homeostasis within a tissue (GO:0048875)2.74404075
128clathrin coat assembly (GO:0048268)2.71019609
129response to dietary excess (GO:0002021)2.70458606
130osteoclast differentiation (GO:0030316)2.70021365
131entrainment of circadian clock by photoperiod (GO:0043153)2.69303804
132antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.68488220
133antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.68488220
134myeloid dendritic cell activation (GO:0001773)2.68231193
135positive regulation of icosanoid secretion (GO:0032305)2.67658967
136positive regulation of interleukin-12 production (GO:0032735)2.67115181
137positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.65544354
138positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.64438384
139peripheral nervous system neuron development (GO:0048935)2.63846910
140tyrosine phosphorylation of STAT protein (GO:0007260)2.63758693
141response to epinephrine (GO:0071871)2.63219261
142positive T cell selection (GO:0043368)2.61598208
143positive regulation of Rap GTPase activity (GO:0032854)2.59849525
144negative regulation of complement activation (GO:0045916)2.59423751
145activation of protein kinase A activity (GO:0034199)2.58006380
146cGMP biosynthetic process (GO:0006182)2.56337615
147ovulation from ovarian follicle (GO:0001542)2.56171930
148cyclic purine nucleotide metabolic process (GO:0052652)2.55892831
149negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.55561376
150response to nitric oxide (GO:0071731)2.52391748
151ethanol metabolic process (GO:0006067)2.52389724
152polyol transport (GO:0015791)2.49198909
153vascular endothelial growth factor signaling pathway (GO:0038084)2.48654408
154glycerolipid catabolic process (GO:0046503)2.47236591
155phospholipid homeostasis (GO:0055091)2.45137575
156negative regulation of homotypic cell-cell adhesion (GO:0034111)2.44683284
157negative regulation of protein activation cascade (GO:2000258)2.44098126
158protein heterotrimerization (GO:0070208)2.43182250
159negative regulation of smooth muscle cell proliferation (GO:0048662)2.43111720
160positive regulation of endothelial cell differentiation (GO:0045603)2.42492440
161regulation of cholesterol storage (GO:0010885)2.42432880
162response to mercury ion (GO:0046689)2.41067199
163adhesion of symbiont to host cell (GO:0044650)2.40102786
164virion attachment to host cell (GO:0019062)2.40102786
165cyclic nucleotide biosynthetic process (GO:0009190)2.39347168
166regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.38793268
167peptide catabolic process (GO:0043171)2.37740299
168diacylglycerol metabolic process (GO:0046339)2.37484602
169cell migration involved in heart development (GO:0060973)2.33333161
170positive regulation of systemic arterial blood pressure (GO:0003084)2.31478868
171regulation of glucose import in response to insulin stimulus (GO:2001273)2.31457362
172regulation of triglyceride catabolic process (GO:0010896)2.30547902
173regulation of vasculogenesis (GO:2001212)2.26877170
174renal absorption (GO:0070293)2.25527743
175negative regulation of granulocyte differentiation (GO:0030853)2.24267346
176negative regulation of vascular permeability (GO:0043116)2.24205859
177lymphangiogenesis (GO:0001946)2.24103975
178platelet degranulation (GO:0002576)2.23720017
179metanephric nephron epithelium development (GO:0072243)2.23197965
180negative regulation of blood coagulation (GO:0030195)2.21847297
181negative regulation of hemostasis (GO:1900047)2.21847297
182retina vasculature morphogenesis in camera-type eye (GO:0061299)2.20645155
183negative regulation of protein localization to cell surface (GO:2000009)2.20477382
184regulation of macrophage chemotaxis (GO:0010758)2.19531791
185regulation of platelet activation (GO:0010543)2.19032115
186arginine catabolic process (GO:0006527)2.17930201
187extracellular matrix assembly (GO:0085029)2.17708394
188negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.17483611
189regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.15002547
190regulation of plasminogen activation (GO:0010755)2.14443286
191protein-lipid complex remodeling (GO:0034368)2.14143279
192macromolecular complex remodeling (GO:0034367)2.14143279
193plasma lipoprotein particle remodeling (GO:0034369)2.14143279

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.85255520
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.69464516
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.08924145
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.19730579
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.02294373
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.94551623
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.92415204
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.92282532
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.92239651
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.67778087
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.60706034
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.54413435
13CLOCK_20551151_ChIP-Seq_293T_Human2.53591722
14RUNX_20019798_ChIP-Seq_JUKART_Human2.29543344
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.21859283
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.12693510
17GATA2_21666600_ChIP-Seq_HMVEC_Human2.05839989
18RXR_22158963_ChIP-Seq_LIVER_Mouse2.03898107
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.01183178
20MYC_22102868_ChIP-Seq_BL_Human1.97128736
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.93795830
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.92469047
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.90052711
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89786172
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87969863
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.84653750
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.81656912
28LXR_22292898_ChIP-Seq_THP-1_Human1.79895594
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.79165453
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78847944
31TCF7_22412390_ChIP-Seq_EML_Mouse1.77768058
32LXR_22158963_ChIP-Seq_LIVER_Mouse1.76827243
33PPARA_22158963_ChIP-Seq_LIVER_Mouse1.74228905
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.74078879
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.71489927
36MYB_26560356_Chip-Seq_TH2_Human1.67964032
37MAF_26560356_Chip-Seq_TH1_Human1.67646820
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62874515
39TBX20_22328084_ChIP-Seq_HEART_Mouse1.59772302
40TBX20_22080862_ChIP-Seq_HEART_Mouse1.59772302
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.58907237
42DROSHA_22980978_ChIP-Seq_HELA_Human1.57998566
43KDM2B_26808549_Chip-Seq_DND41_Human1.56800827
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53664179
45VDR_24787735_ChIP-Seq_THP-1_Human1.52763470
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51769195
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.49504943
48EZH2_22144423_ChIP-Seq_EOC_Human1.48647013
49SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46790695
50* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46760952
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46425307
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46367738
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44483698
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.41673965
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40803001
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.38981720
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.38350407
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.37700644
59GATA1_22025678_ChIP-Seq_K562_Human1.37455140
60MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37335887
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36749465
62PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.36340915
63KDM2B_26808549_Chip-Seq_K562_Human1.36246783
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35980069
65ZNF263_19887448_ChIP-Seq_K562_Human1.34693059
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32876481
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32840014
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32512635
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32374017
70SCL_19346495_ChIP-Seq_HPC-7_Human1.32257252
71MYB_26560356_Chip-Seq_TH1_Human1.31912852
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.30224518
73JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28688583
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.27751702
75UTX_26944678_Chip-Seq_JUKART_Human1.26314560
76SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23954700
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23128186
78IRF8_27001747_Chip-Seq_BMDM_Mouse1.22628227
79JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22594898
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22497664
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.22131273
82KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21362522
83KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21362522
84KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21362522
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21218615
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20802932
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20640013
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19680468
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19673600
90ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.18944771
91CTCF_27219007_Chip-Seq_Bcells_Human1.18313939
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18114636
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18007311
94NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17103987
95UBF1/2_26484160_Chip-Seq_HMECs_Human1.16660356
96PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16586633
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16247495
98GATA1_19941827_ChIP-Seq_MEL_Mouse1.16031629
99MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15797714
100NOTCH1_21737748_ChIP-Seq_TLL_Human1.15765858
101* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15404621
102RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14671676
103EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14671676
104SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14485849
105RACK7_27058665_Chip-Seq_MCF-7_Human1.14291105
106SMAD3_21741376_ChIP-Seq_HESCs_Human1.14131065
107NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14015739
108ATF3_27146783_Chip-Seq_COLON_Human1.13767488
109SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13105161
110SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13105161
111RAD21_21589869_ChIP-Seq_MESCs_Mouse1.13084995
112CJUN_26792858_Chip-Seq_BT549_Human1.11051821
113EP300_21415370_ChIP-Seq_HL-1_Mouse1.09796422
114NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08905679
115WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06854683
116EZH2_27294783_Chip-Seq_ESCs_Mouse1.05830463
117AHR_22903824_ChIP-Seq_MCF-7_Human1.05174191
118JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05172875
119* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04301894
120WT1_19549856_ChIP-ChIP_CCG9911_Human1.01497389
121KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01159915
122PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00913520
123* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00667236
124* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00034910
125RUNX1_27514584_Chip-Seq_MCF-7_Human0.99849306
126VDR_24763502_ChIP-Seq_THP-1_Human0.99463766
127E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99230209
128SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98636784
129GATA3_27048872_Chip-Seq_THYMUS_Human0.97552909
130ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97368113
131SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97262808
132PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96668161
133IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95344223
134* SMC4_20622854_ChIP-Seq_HELA_Human0.94571015
135SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94142542
136SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93246598
137Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93017442
138ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92824775
139* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92705556
140EED_16625203_ChIP-ChIP_MESCs_Mouse0.92328628
141NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91878869
142AR_21572438_ChIP-Seq_LNCaP_Human0.91354466
143SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90891222
144CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90565275
145LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89867775
146GATA1_19941826_ChIP-Seq_K562_Human0.89691162
147PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89386861
148RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.89335763
149CDX2_20551321_ChIP-Seq_CACO-2_Human0.88974305
150SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88567113
151WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88441333
152EGR1_23403033_ChIP-Seq_LIVER_Mouse0.87925279
153FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87701864
154RUNX1_22412390_ChIP-Seq_EML_Mouse0.87048047
155SOX2_20726797_ChIP-Seq_SW620_Human0.86983292
156CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86667775
157BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86355724
158P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85407534
159GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82593022
160GATA2_19941826_ChIP-Seq_K562_Human0.82127701
161RXR_22108803_ChIP-Seq_LS180_Human0.81982895
162MAF_26560356_Chip-Seq_TH2_Human0.81634381
163UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.80990133
164FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80658258
165STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80518909
166TP53_16413492_ChIP-PET_HCT116_Human0.80194554
167ZFP281_18757296_ChIP-ChIP_E14_Mouse0.80015706
168EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.78973229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose4.38938233
2MP0002138_abnormal_hepatobiliary_system4.19323726
3MP0003724_increased_susceptibility_to3.59637318
4MP0000685_abnormal_immune_system3.57331753
5MP0004510_myositis3.50352702
6MP0001879_abnormal_lymphatic_vessel3.34067354
7MP0006054_spinal_hemorrhage3.08426790
8MP0005167_abnormal_blood-brain_barrier2.90757490
9MP0000751_myopathy2.89958747
10MP0010368_abnormal_lymphatic_system2.77398077
11MP0005623_abnormal_meninges_morphology2.75629885
12MP0005666_abnormal_adipose_tissue2.70935651
13MP0005275_abnormal_skin_tensile2.64363423
14MP0006138_congestive_heart_failure2.61273013
15MP0005387_immune_system_phenotype2.53970373
16MP0001790_abnormal_immune_system2.53970373
17MP0004084_abnormal_cardiac_muscle2.52592693
18MP0005671_abnormal_response_to2.40079054
19MP0003303_peritoneal_inflammation2.39748362
20MP0003763_abnormal_thymus_physiology2.39253935
21MP0004130_abnormal_muscle_cell2.38784368
22MP0002877_abnormal_melanocyte_morpholog2.26315776
23MP0001958_emphysema2.22173467
24MP0004947_skin_inflammation2.21591656
25MP0005000_abnormal_immune_tolerance2.20254648
26MP0001348_abnormal_lacrimal_gland2.12758615
27MP0001800_abnormal_humoral_immune2.09063320
28MP0002254_reproductive_system_inflammat2.08087293
29MP0003300_gastrointestinal_ulcer2.07587706
30MP0005375_adipose_tissue_phenotype2.06790006
31MP0002405_respiratory_system_inflammati2.05384874
32MP0003011_delayed_dark_adaptation2.05257330
33MP0004036_abnormal_muscle_relaxation2.01914837
34MP0002971_abnormal_brown_adipose1.94202069
35MP0010155_abnormal_intestine_physiology1.92144111
36MP0008438_abnormal_cutaneous_collagen1.90050712
37MP0008004_abnormal_stomach_pH1.87885858
38MP0001851_eye_inflammation1.85705454
39MP0004215_abnormal_myocardial_fiber1.83325648
40MP0002723_abnormal_immune_serum1.83009505
41MP0000249_abnormal_blood_vessel1.81869822
42MP0000465_gastrointestinal_hemorrhage1.79910815
43MP0009785_altered_susceptibility_to1.76774393
44MP0001881_abnormal_mammary_gland1.76546239
45MP0001502_abnormal_circadian_rhythm1.74008943
46MP0010234_abnormal_vibrissa_follicle1.71739988
47MP0001544_abnormal_cardiovascular_syste1.67462541
48MP0005385_cardiovascular_system_phenoty1.67462541
49MP0002452_abnormal_antigen_presenting1.67188902
50MP0003091_abnormal_cell_migration1.64267599
51MP0001819_abnormal_immune_cell1.63534150
52MP0004272_abnormal_basement_membrane1.62898843
53MP0010329_abnormal_lipoprotein_level1.62645444
54MP0002420_abnormal_adaptive_immunity1.61373306
55MP0004782_abnormal_surfactant_physiolog1.59501754
56MP0009333_abnormal_splenocyte_physiolog1.59047827
57MP0003828_pulmonary_edema1.57472678
58MP0005464_abnormal_platelet_physiology1.56908401
59MP0002972_abnormal_cardiac_muscle1.47577212
60MP0005409_darkened_coat_color1.46141135
61MP0000858_altered_metastatic_potential1.45416577
62MP0002166_altered_tumor_susceptibility1.44569045
63MP0003191_abnormal_cellular_cholesterol1.43869845
64MP0002108_abnormal_muscle_morphology1.42937584
65MP0005058_abnormal_lysosome_morphology1.42117224
66MP0004883_abnormal_blood_vessel1.41546420
67MP0003705_abnormal_hypodermis_morpholog1.39884373
68MP0000343_altered_response_to1.39544345
69MP0002876_abnormal_thyroid_physiology1.39047846
70MP0003436_decreased_susceptibility_to1.38237910
71MP0002933_joint_inflammation1.38011379
72MP0009115_abnormal_fat_cell1.37475262
73MP0003566_abnormal_cell_adhesion1.37345319
74MP0002398_abnormal_bone_marrow1.34275147
75MP0000703_abnormal_thymus_morphology1.33517964
76MP0001835_abnormal_antigen_presentation1.33247312
77MP0009780_abnormal_chondrocyte_physiolo1.31947962
78MP0000013_abnormal_adipose_tissue1.30818471
79MP0000767_abnormal_smooth_muscle1.29907843
80MP0003045_fibrosis1.29016999
81MP0005620_abnormal_muscle_contractility1.28925619
82MP0003690_abnormal_glial_cell1.28679127
83MP0000003_abnormal_adipose_tissue1.28624915
84MP0002148_abnormal_hypersensitivity_rea1.28418055
85MP0005535_abnormal_body_temperature1.26824132
86MP0005503_abnormal_tendon_morphology1.26794153
87MP0002277_abnormal_respiratory_mucosa1.26263933
88MP0005360_urolithiasis1.26175624
89MP0000716_abnormal_immune_system1.21079666
90MP0000230_abnormal_systemic_arterial1.20551927
91MP0001853_heart_inflammation1.20080257
92MP0003866_abnormal_defecation1.19914372
93MP0001845_abnormal_inflammatory_respons1.18298286
94MP0004087_abnormal_muscle_fiber1.18029813
95MP0005330_cardiomyopathy1.17333888
96MP0001533_abnormal_skeleton_physiology1.16614859
97MP0005076_abnormal_cell_differentiation1.13869045
98MP0002419_abnormal_innate_immunity1.13135781
99MP0001873_stomach_inflammation1.12206386
100MP0002118_abnormal_lipid_homeostasis1.12180717
101MP0003638_abnormal_response/metabolism_1.11608155
102MP0005025_abnormal_response_to1.10805822
103MP0009840_abnormal_foam_cell1.10746337
104MP0002722_abnormal_immune_system1.08927687
105MP0004185_abnormal_adipocyte_glucose1.08710281
106MP0002006_tumorigenesis1.08470997
107MP0001542_abnormal_bone_strength1.08301665
108MP0005365_abnormal_bile_salt1.08092522
109MP0005310_abnormal_salivary_gland1.07817110
110MP0005164_abnormal_response_to1.07160863
111MP0003075_altered_response_to1.06569194
112MP0002998_abnormal_bone_remodeling1.05480592
113MP0002163_abnormal_gland_morphology1.03986062
114MP0003879_abnormal_hair_cell1.03188247
115MP0005388_respiratory_system_phenotype1.01043514
116MP0002133_abnormal_respiratory_system1.01043514
117MP0002127_abnormal_cardiovascular_syste1.00929794
118MP0003448_altered_tumor_morphology0.99847013
119MP0000689_abnormal_spleen_morphology0.96993063
120MP0005334_abnormal_fat_pad0.96978970
121MP0004484_altered_response_of0.96771984
122MP0006082_CNS_inflammation0.96039987
123MP0005166_decreased_susceptibility_to0.95301167
124MP0010630_abnormal_cardiac_muscle0.94523395
125MP0002429_abnormal_blood_cell0.94067612
126MP0005595_abnormal_vascular_smooth0.92370827
127MP0000749_muscle_degeneration0.91558446
128MP0001501_abnormal_sleep_pattern0.91222027
129MP0003646_muscle_fatigue0.91052779
130MP0001849_ear_inflammation0.90334070
131MP0003453_abnormal_keratinocyte_physiol0.89734034
132MP0005165_increased_susceptibility_to0.89277880
133MP0004085_abnormal_heartbeat0.88382511
134MP0003329_amyloid_beta_deposits0.88261036
135MP0004808_abnormal_hematopoietic_stem0.86634381
136MP0005448_abnormal_energy_balance0.86370907
137MP0002128_abnormal_blood_circulation0.85322305
138MP0008961_abnormal_basal_metabolism0.83737912
139MP0003868_abnormal_feces_composition0.82732793
140MP0005369_muscle_phenotype0.82307407
141MP0004264_abnormal_extraembryonic_tissu0.82278783
142MP0009643_abnormal_urine_homeostasis0.80945332
143MP0002970_abnormal_white_adipose0.80138998
144MP0002925_abnormal_cardiovascular_devel0.79337860
145MP0005390_skeleton_phenotype0.79320063
146MP0003787_abnormal_imprinting0.78990359
147MP0002295_abnormal_pulmonary_circulatio0.78118235
148MP0004019_abnormal_vitamin_homeostasis0.77145536
149MP0002139_abnormal_hepatobiliary_system0.76576238
150MP0002136_abnormal_kidney_physiology0.76449496
151MP0005187_abnormal_penis_morphology0.76022919
152MP0000747_muscle_weakness0.76006414
153MP0003137_abnormal_impulse_conducting0.75761835
154MP0001191_abnormal_skin_condition0.75722068
155MP0008874_decreased_physiological_sensi0.75071061
156MP0000537_abnormal_urethra_morphology0.74726280
157MP0000759_abnormal_skeletal_muscle0.74706508
158MP0001614_abnormal_blood_vessel0.74304154
159MP0005023_abnormal_wound_healing0.74104426
160MP0003959_abnormal_lean_body0.72835473
161MP0001661_extended_life_span0.71451131
162MP0003279_aneurysm0.68837683
163MP0008775_abnormal_heart_ventricle0.68348425
164MP0002009_preneoplasia0.64101253
165MP0003795_abnormal_bone_structure0.63946779
166MP0000733_abnormal_muscle_development0.61423922

Predicted human phenotypes

RankGene SetZ-score
1Optic neuritis (HP:0100653)7.57855539
2Retrobulbar optic neuritis (HP:0100654)7.57855539
3Orchitis (HP:0100796)7.37383865
4Increased density of long bones (HP:0006392)7.23601068
5Myositis (HP:0100614)6.50930726
6Complement deficiency (HP:0004431)6.17653782
7Systemic lupus erythematosus (HP:0002725)6.16309980
8Persistence of primary teeth (HP:0006335)5.69286719
9Abnormality of complement system (HP:0005339)5.34211807
10Keratoconjunctivitis sicca (HP:0001097)5.06967888
11Stomatitis (HP:0010280)4.88829648
12Keratoconjunctivitis (HP:0001096)4.64441386
13Glomerulonephritis (HP:0000099)4.26810020
14Autoimmune hemolytic anemia (HP:0001890)4.23857291
15Elevated erythrocyte sedimentation rate (HP:0003565)4.08689903
16Arterial thrombosis (HP:0004420)4.03441246
17Muscle fiber splitting (HP:0003555)3.96712128
18Hyperlipoproteinemia (HP:0010980)3.83960329
19Pulmonary infiltrates (HP:0002113)3.66607952
20Vascular tortuosity (HP:0004948)3.65251043
21Increased variability in muscle fiber diameter (HP:0003557)3.47773511
22Severe combined immunodeficiency (HP:0004430)3.45929266
23Hemoptysis (HP:0002105)3.39374587
24Purpura (HP:0000979)3.35169919
25Abnormality of the nasal mucosa (HP:0000433)3.34282606
26Joint hemorrhage (HP:0005261)3.33700324
27Hyporeflexia of lower limbs (HP:0002600)3.32940724
28Increased connective tissue (HP:0009025)3.29535482
29Nephritis (HP:0000123)3.27374261
30Prolonged bleeding time (HP:0003010)3.26855115
31Distal lower limb muscle weakness (HP:0009053)3.21804466
32Menorrhagia (HP:0000132)3.18384495
33Autoimmune thrombocytopenia (HP:0001973)3.17255679
34Abnormality of skeletal muscle fiber size (HP:0012084)3.16474992
35Thyroiditis (HP:0100646)3.15070623
36Bundle branch block (HP:0011710)3.14149229
37B lymphocytopenia (HP:0010976)3.13056334
38Abnormality of B cell number (HP:0010975)3.13056334
39Aortic aneurysm (HP:0004942)3.03672586
40Polycythemia (HP:0001901)3.02237235
41Oligomenorrhea (HP:0000876)2.96010475
42Hypertriglyceridemia (HP:0002155)2.93772630
43Pulmonary embolism (HP:0002204)2.89301753
44Abnormality of the nasal septum (HP:0000419)2.86502260
45Asymmetric septal hypertrophy (HP:0001670)2.84329967
46Increased IgE level (HP:0003212)2.83276860
47Type 1 muscle fiber predominance (HP:0003803)2.82397819
48Deformed tarsal bones (HP:0008119)2.81209385
49Protrusio acetabuli (HP:0003179)2.80945335
50Growth hormone excess (HP:0000845)2.78331868
51Abnormal atrioventricular conduction (HP:0005150)2.75846825
52Acanthosis nigricans (HP:0000956)2.74682403
53Combined immunodeficiency (HP:0005387)2.74385491
54Sudden death (HP:0001699)2.73499616
55Lymphangioma (HP:0100764)2.72619408
56Colitis (HP:0002583)2.72272372
57Abnormality of the pericardium (HP:0001697)2.70843982
58Vasculitis (HP:0002633)2.70181834
59Heart block (HP:0012722)2.68122696
60Segmental peripheral demyelination/remyelination (HP:0003481)2.63967337
61Xanthomatosis (HP:0000991)2.63668235
62Gangrene (HP:0100758)2.54406137
63Facial diplegia (HP:0001349)2.53880945
64Atrioventricular block (HP:0001678)2.51660961
65Difficulty running (HP:0009046)2.51234108
66Cerebral aneurysm (HP:0004944)2.49212319
67Spontaneous hematomas (HP:0007420)2.48771889
68Calcaneovalgus deformity (HP:0001848)2.47473664
69Increased mean platelet volume (HP:0011877)2.47467265
70Hemorrhage of the eye (HP:0011885)2.47131177
71Cerebral hemorrhage (HP:0001342)2.46754511
72Anorexia (HP:0002039)2.45294839
73Abnormality of the calcaneus (HP:0008364)2.43686656
74Atrial fibrillation (HP:0005110)2.41580099
75Right ventricular cardiomyopathy (HP:0011663)2.40999591
76Epistaxis (HP:0000421)2.40423397
77Bulbar palsy (HP:0001283)2.39263724
78Exercise-induced myalgia (HP:0003738)2.37897346
79Arterial tortuosity (HP:0005116)2.37041329
80Ventricular tachycardia (HP:0004756)2.36538945
81IgM deficiency (HP:0002850)2.36437623
82Hematochezia (HP:0002573)2.35142274
83Lipoatrophy (HP:0100578)2.34304439
84Axonal loss (HP:0003447)2.32534657
85Premature loss of primary teeth (HP:0006323)2.32515514
86Hand muscle atrophy (HP:0009130)2.32509393
87Mildly elevated creatine phosphokinase (HP:0008180)2.31823117
88Abnormality of eosinophils (HP:0001879)2.29904168
89Primary atrial arrhythmia (HP:0001692)2.28925403
90Esophageal varix (HP:0002040)2.27172941
91Interstitial pulmonary disease (HP:0006530)2.26327688
92Abnormal platelet volume (HP:0011876)2.26075417
93Neck muscle weakness (HP:0000467)2.24312850
94Abnormality of monocarboxylic acid metabolism (HP:0010996)2.23596125
95Skin nodule (HP:0200036)2.22545853
96Subacute progressive viral hepatitis (HP:0006572)2.22113576
97Pigmentary retinal degeneration (HP:0001146)2.21952042
98Supraventricular tachycardia (HP:0004755)2.20763036
99Upper limb amyotrophy (HP:0009129)2.19183878
100Distal upper limb amyotrophy (HP:0007149)2.19183878
101Amyloidosis (HP:0011034)2.19166457
102Supraventricular arrhythmia (HP:0005115)2.19138023
103Rhinitis (HP:0012384)2.18932483
104Increased IgM level (HP:0003496)2.18502253
105Ventricular fibrillation (HP:0001663)2.18492426
106Recurrent fungal infections (HP:0002841)2.17245510
107Conjunctival telangiectasia (HP:0000524)2.17156572
108Thrombophlebitis (HP:0004418)2.16388342
109Spinal rigidity (HP:0003306)2.15352629
110Foot dorsiflexor weakness (HP:0009027)2.13496542
111Broad metatarsal (HP:0001783)2.13098729
112Lower limb amyotrophy (HP:0007210)2.12330592
113Pulmonary artery stenosis (HP:0004415)2.11595847
114IgG deficiency (HP:0004315)2.10476395
115Dilatation of the ascending aorta (HP:0005111)2.09026145
116Cerebral palsy (HP:0100021)2.08848524
117Eosinophilia (HP:0001880)2.07828210
118Abnormality of the foot musculature (HP:0001436)2.07780925
119Abnormality of the pleura (HP:0002103)2.06727573
120Syncope (HP:0001279)2.05513267
121Ventricular arrhythmia (HP:0004308)2.05097867
122Fatigue (HP:0012378)2.05042408
123Deep venous thrombosis (HP:0002625)2.04716528
124Round ear (HP:0100830)2.04666954
125Malnutrition (HP:0004395)2.02071864
126Visceral angiomatosis (HP:0100761)2.01908660
127Hypercortisolism (HP:0001578)2.01203509
128Vertebral compression fractures (HP:0002953)1.99072274
129Aortic dissection (HP:0002647)1.98861049
130Stridor (HP:0010307)1.97702344
131Keratitis (HP:0000491)1.97300377
132Diplopia (HP:0000651)1.97206038
133Abnormality of binocular vision (HP:0011514)1.97206038
134Leukocytosis (HP:0001974)1.97178453
135Bone cyst (HP:0012062)1.96881177
136Nasal polyposis (HP:0100582)1.96723947
137Distal lower limb amyotrophy (HP:0008944)1.96230705
138Porencephaly (HP:0002132)1.96077516
139IgA deficiency (HP:0002720)1.95990692
140Pulmonary hypertension (HP:0002092)1.95767117
141Abnormality of T cell number (HP:0011839)1.95172994
142Vertigo (HP:0002321)1.93772867
143Stroke (HP:0001297)1.93057845
144Obstructive sleep apnea (HP:0002870)1.92767526
145Adactyly (HP:0009776)1.92235309
146J-shaped sella turcica (HP:0002680)1.91900110
147Centrally nucleated skeletal muscle fibers (HP:0003687)1.91103671
148Encephalitis (HP:0002383)1.90693905
149Recurrent gram-negative bacterial infections (HP:0005420)1.89480819
150Hemiplegia (HP:0002301)1.88724451
151Nuclear cataract (HP:0100018)1.88557488
152Gastrointestinal infarctions (HP:0005244)1.88113148
153Mitral stenosis (HP:0001718)1.85408461
154Joint stiffness (HP:0001387)1.85199616
155EMG: myopathic abnormalities (HP:0003458)1.84907137
156Glomerulopathy (HP:0100820)1.83266375
157Emphysema (HP:0002097)1.82336882
158Dilated cardiomyopathy (HP:0001644)1.80806287
159Prolonged QT interval (HP:0001657)1.80114590
160Shallow orbits (HP:0000586)1.80106203
161Chest pain (HP:0100749)1.79817673
162Inflammation of the large intestine (HP:0002037)1.78903392
163Dysostosis multiplex (HP:0000943)1.76966684
164Gastrointestinal dysmotility (HP:0002579)1.76802218
165Cervical subluxation (HP:0003308)1.75932144
166Cerebral ischemia (HP:0002637)1.75134014
167Petechiae (HP:0000967)1.74779267
168Abnormality of the vasculature of the conjunctiva (HP:0008054)1.74561135
169Hemangiomatosis (HP:0007461)1.74178903
170Annular pancreas (HP:0001734)1.73271732
171Myocardial infarction (HP:0001658)1.72920316
172Wrist flexion contracture (HP:0001239)1.71805293
173Abnormality of the calf musculature (HP:0001430)1.71492790
174Joint swelling (HP:0001386)1.71455539
175Ileus (HP:0002595)1.71386482
176Aneurysm (HP:0002617)1.70815345
177Eczematoid dermatitis (HP:0000976)1.67554462
178Sparse lateral eyebrow (HP:0005338)1.67070331
179Gastrointestinal stroma tumor (HP:0100723)1.65575277
180Paresthesia (HP:0003401)1.65028068
181Acrocyanosis (HP:0001063)1.63981942
182Hypergammaglobulinemia (HP:0010702)1.63374058
183Diaphragmatic weakness (HP:0009113)1.62938252
184T lymphocytopenia (HP:0005403)1.61750351
185Gastrointestinal inflammation (HP:0004386)1.58170700
186Somatic mutation (HP:0001428)1.58015175
187Atonic seizures (HP:0010819)1.57959146
188Hypoalbuminemia (HP:0003073)1.56005002

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.14299363
2MAP3K144.22298726
3TXK3.85184933
4TAOK33.19415136
5TSSK62.89788661
6KDR2.88464783
7IRAK32.76867695
8TBK12.32884869
9RIPK12.25204206
10MAP4K12.23584472
11ITK2.19921724
12TGFBR22.15823859
13TEC2.13161128
14CHUK2.06709164
15MAPKAPK31.96223553
16FER1.89953516
17PTK61.89199291
18PIM21.81115200
19SIK11.78413148
20TGFBR11.76515998
21IKBKE1.75738421
22EPHA21.72360166
23PDK21.68838775
24IKBKB1.64510358
25JAK11.60919206
26JAK31.58455270
27CDC42BPA1.53413500
28DDR21.50865221
29BMX1.47211225
30EPHB11.45862682
31MAP3K121.38084301
32PIM11.37880565
33MUSK1.37015641
34GRK51.35257309
35OBSCN1.30531173
36PTK2B1.30372941
37AKT31.30024602
38RIPK41.29204368
39PDGFRA1.25467083
40LATS21.14818146
41GRK61.11889585
42GSK3A1.10070147
43PRKAA21.09808363
44ERN11.09320862
45PTK21.03869873
46ZAP701.02185150
47HCK1.01369242
48DAPK31.00579183
49MAPK40.97252536
50ILK0.97068332
51PAK40.96274261
52PDPK10.95673079
53GRK10.95189998
54EEF2K0.94591083
55RET0.93152271
56FGFR40.92055888
57CAMK10.91739146
58FES0.91510283
59MAPK120.89954189
60PRKCH0.89434062
61EPHA30.87474020
62MAP3K110.84855582
63TRPM70.84139323
64STK100.82930119
65PKN20.82846171
66PRPF4B0.82434459
67NLK0.82220105
68TAOK10.82044134
69MAP2K30.79979323
70MST40.79938148
71KIT0.77209373
72MARK20.76586318
73MAP3K30.75232705
74PRKG20.74479726
75EPHB20.74339473
76MAP3K70.73245159
77BLK0.72911029
78LMTK20.72480842
79PHKG20.72079655
80PHKG10.72079655
81ROCK10.71856358
82MAP3K130.70803733
83NEK60.70596701
84NTRK30.70093062
85BTK0.69882798
86HIPK20.66279972
87LCK0.65353240
88TYK20.63612906
89MAP3K60.63197641
90PKN10.63150703
91PIK3CA0.62954782
92MST1R0.62429208
93CSK0.61954791
94RPS6KA20.61952233
95DAPK20.61604814
96PAK60.61115768
97TNK20.61039026
98ABL20.60735142
99PIK3CG0.60631728
100DMPK0.59881987
101MAPK70.58536631
102PRKACG0.57201331
103CDK60.57039652
104PINK10.56508284
105FGFR30.52635588
106PRKCQ0.52504511
107PDGFRB0.50678633
108ROCK20.49649619
109MAP2K10.49562002
110ARAF0.49403149
111RPS6KC10.46832469
112RPS6KL10.46832469
113ERBB20.46765055
114JAK20.46388487
115SGK4940.45329701
116SGK2230.45329701
117PRKG10.45130884
118RPS6KA10.45108579
119TRIB30.44740664
120IGF1R0.44103956
121ADRBK10.42614842
122CAMK2D0.42588953
123SYK0.41081384
124SIK30.40903903
125LRRK20.39586549
126INSR0.39534000
127SGK20.39278630
128STK110.39186078
129MAPK150.38850888
130MET0.38765037
131TYRO30.37640659
132RPS6KA40.36589884
133BCR0.36378743
134PAK20.35446664
135TTN0.32674886
136TESK10.30625438
137EGFR0.30013239
138MARK30.29083376
139MOS0.28835169
140DYRK1B0.26331594
141MYLK0.25906324
142PDK10.25805405
143CAMK2G0.25752314
144PRKD10.25626010
145FGFR10.24296687
146SRC0.22159251
147CDK120.21585688
148BRD40.21346133
149ABL10.19448163
150MAP3K10.19261533

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.98789575
2Complement and coagulation cascades_Homo sapiens_hsa046102.75690349
3Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.68856120
4PPAR signaling pathway_Homo sapiens_hsa033202.48636775
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.44325613
6Osteoclast differentiation_Homo sapiens_hsa043802.41174563
7Staphylococcus aureus infection_Homo sapiens_hsa051502.36645625
8TNF signaling pathway_Homo sapiens_hsa046682.14269745
9Phenylalanine metabolism_Homo sapiens_hsa003602.09707997
10T cell receptor signaling pathway_Homo sapiens_hsa046602.08157832
11Primary immunodeficiency_Homo sapiens_hsa053402.04871863
12Histidine metabolism_Homo sapiens_hsa003401.94715728
13Measles_Homo sapiens_hsa051621.79125571
14Fatty acid degradation_Homo sapiens_hsa000711.74556297
15Tyrosine metabolism_Homo sapiens_hsa003501.68966036
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.68513072
17Circadian rhythm_Homo sapiens_hsa047101.68266236
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.68002305
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.64855167
20Leishmaniasis_Homo sapiens_hsa051401.62823689
21Toxoplasmosis_Homo sapiens_hsa051451.61731207
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.61458394
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.60900025
24Fat digestion and absorption_Homo sapiens_hsa049751.58747032
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.57752102
26Allograft rejection_Homo sapiens_hsa053301.57311590
27Arginine biosynthesis_Homo sapiens_hsa002201.57220410
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56725176
29Rheumatoid arthritis_Homo sapiens_hsa053231.55960887
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.55283442
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.48866109
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.45790665
33Arachidonic acid metabolism_Homo sapiens_hsa005901.42846082
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41448143
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.39954298
36Prion diseases_Homo sapiens_hsa050201.39156171
37Glycerolipid metabolism_Homo sapiens_hsa005611.38376681
38Hematopoietic cell lineage_Homo sapiens_hsa046401.33790529
39Legionellosis_Homo sapiens_hsa051341.32884715
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28740339
41Antigen processing and presentation_Homo sapiens_hsa046121.25763811
42Autoimmune thyroid disease_Homo sapiens_hsa053201.25140680
43Bile secretion_Homo sapiens_hsa049761.24672116
44Linoleic acid metabolism_Homo sapiens_hsa005911.24095296
45Prolactin signaling pathway_Homo sapiens_hsa049171.23974160
46B cell receptor signaling pathway_Homo sapiens_hsa046621.22445255
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.20447095
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20343341
49Graft-versus-host disease_Homo sapiens_hsa053321.17708040
50Shigellosis_Homo sapiens_hsa051311.14743901
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14666442
52Viral myocarditis_Homo sapiens_hsa054161.11520710
53MAPK signaling pathway_Homo sapiens_hsa040101.10862077
54Retinol metabolism_Homo sapiens_hsa008301.10445955
55Chemokine signaling pathway_Homo sapiens_hsa040621.09649245
56Tryptophan metabolism_Homo sapiens_hsa003801.09630189
57Hepatitis B_Homo sapiens_hsa051611.05082158
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04262650
59HIF-1 signaling pathway_Homo sapiens_hsa040661.02345691
60Apoptosis_Homo sapiens_hsa042101.00354236
61Chemical carcinogenesis_Homo sapiens_hsa052040.99870954
62Focal adhesion_Homo sapiens_hsa045100.99446915
63Small cell lung cancer_Homo sapiens_hsa052220.99248891
64Influenza A_Homo sapiens_hsa051640.98549451
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98372867
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98213836
67Platelet activation_Homo sapiens_hsa046110.97862564
68Salmonella infection_Homo sapiens_hsa051320.97050459
69Arginine and proline metabolism_Homo sapiens_hsa003300.96255284
70Estrogen signaling pathway_Homo sapiens_hsa049150.94745208
71Malaria_Homo sapiens_hsa051440.93818163
72Adherens junction_Homo sapiens_hsa045200.93458640
73VEGF signaling pathway_Homo sapiens_hsa043700.93190900
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93181354
75Proteoglycans in cancer_Homo sapiens_hsa052050.92471736
76HTLV-I infection_Homo sapiens_hsa051660.92153286
77Rap1 signaling pathway_Homo sapiens_hsa040150.91410130
78beta-Alanine metabolism_Homo sapiens_hsa004100.90531124
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.89746819
80Acute myeloid leukemia_Homo sapiens_hsa052210.89230475
81Dilated cardiomyopathy_Homo sapiens_hsa054140.88832972
82Ovarian steroidogenesis_Homo sapiens_hsa049130.87909246
83Chronic myeloid leukemia_Homo sapiens_hsa052200.87611909
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.87329970
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87281356
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86254013
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85391022
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.85320147
89Amoebiasis_Homo sapiens_hsa051460.85289058
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84997187
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84956279
92Renin-angiotensin system_Homo sapiens_hsa046140.84791897
93Asthma_Homo sapiens_hsa053100.84500355
94Other glycan degradation_Homo sapiens_hsa005110.83750460
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.83290991
96Renin secretion_Homo sapiens_hsa049240.81499020
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76913571
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76273677
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.75629049
100ECM-receptor interaction_Homo sapiens_hsa045120.75469410
101AMPK signaling pathway_Homo sapiens_hsa041520.75428758
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74231466
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73878388
104Epstein-Barr virus infection_Homo sapiens_hsa051690.73512105
105ABC transporters_Homo sapiens_hsa020100.73403307
106Pertussis_Homo sapiens_hsa051330.73334265
107Cocaine addiction_Homo sapiens_hsa050300.72965021
108Hepatitis C_Homo sapiens_hsa051600.71661842
109Pancreatic secretion_Homo sapiens_hsa049720.69984884
110Gap junction_Homo sapiens_hsa045400.67346797
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67189583
112Type I diabetes mellitus_Homo sapiens_hsa049400.66622007
113Ras signaling pathway_Homo sapiens_hsa040140.66244494
114Insulin signaling pathway_Homo sapiens_hsa049100.65583572
115Notch signaling pathway_Homo sapiens_hsa043300.65393098
116Renal cell carcinoma_Homo sapiens_hsa052110.65182335
117ErbB signaling pathway_Homo sapiens_hsa040120.64201730
118Colorectal cancer_Homo sapiens_hsa052100.63881718
119Endocytosis_Homo sapiens_hsa041440.63820495
120Fatty acid elongation_Homo sapiens_hsa000620.63070840
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62572464
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62419362
123Thyroid cancer_Homo sapiens_hsa052160.62288995
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62093905
125Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61751954
126Pancreatic cancer_Homo sapiens_hsa052120.61011824
127Oxytocin signaling pathway_Homo sapiens_hsa049210.59478143
128Tuberculosis_Homo sapiens_hsa051520.59312021
129Pathways in cancer_Homo sapiens_hsa052000.59007509
130FoxO signaling pathway_Homo sapiens_hsa040680.58914871
131TGF-beta signaling pathway_Homo sapiens_hsa043500.58562228
132Prostate cancer_Homo sapiens_hsa052150.58336423
133Protein digestion and absorption_Homo sapiens_hsa049740.58088570
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56899655
135Synaptic vesicle cycle_Homo sapiens_hsa047210.56399711
136Fatty acid biosynthesis_Homo sapiens_hsa000610.55853556
137Mineral absorption_Homo sapiens_hsa049780.55760557
138Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54369103
139MicroRNAs in cancer_Homo sapiens_hsa052060.53602194
140GnRH signaling pathway_Homo sapiens_hsa049120.53251880
141Dorso-ventral axis formation_Homo sapiens_hsa043200.52357767
142Melanogenesis_Homo sapiens_hsa049160.52104218
143Circadian entrainment_Homo sapiens_hsa047130.52031228
144Gastric acid secretion_Homo sapiens_hsa049710.51915239
145Insulin resistance_Homo sapiens_hsa049310.51690011
146Herpes simplex infection_Homo sapiens_hsa051680.51584307
147Morphine addiction_Homo sapiens_hsa050320.51301132
148cAMP signaling pathway_Homo sapiens_hsa040240.50984608
149Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50881595
150Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50511956
151Viral carcinogenesis_Homo sapiens_hsa052030.50298906
152Serotonergic synapse_Homo sapiens_hsa047260.49763212
153* Vascular smooth muscle contraction_Homo sapiens_hsa042700.49418787
154Phagosome_Homo sapiens_hsa041450.47634488
155Starch and sucrose metabolism_Homo sapiens_hsa005000.47319878
156Glutathione metabolism_Homo sapiens_hsa004800.47284757
157Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47119164
158Fatty acid metabolism_Homo sapiens_hsa012120.44788035
159Sulfur metabolism_Homo sapiens_hsa009200.41974580
160Lysosome_Homo sapiens_hsa041420.40802068
161Steroid hormone biosynthesis_Homo sapiens_hsa001400.40440598
162Tight junction_Homo sapiens_hsa045300.40433819
163Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39870702
164Calcium signaling pathway_Homo sapiens_hsa040200.37650842
165Cardiac muscle contraction_Homo sapiens_hsa042600.37365615

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