RAN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.03159499
2DNA unwinding involved in DNA replication (GO:0006268)4.78988675
3DNA strand elongation (GO:0022616)4.76774089
4ribosomal small subunit assembly (GO:0000028)4.73725523
5DNA replication initiation (GO:0006270)4.69275149
6telomere maintenance via semi-conservative replication (GO:0032201)4.68105002
7maturation of SSU-rRNA (GO:0030490)4.55875844
8viral transcription (GO:0019083)4.50841876
9translational termination (GO:0006415)4.46424546
10nucleobase biosynthetic process (GO:0046112)4.29653864
11formation of translation preinitiation complex (GO:0001731)4.27006237
12ribosomal large subunit biogenesis (GO:0042273)4.22829287
13telomere maintenance via recombination (GO:0000722)4.18662030
14protein localization to kinetochore (GO:0034501)4.18421116
15DNA replication checkpoint (GO:0000076)4.18378189
16ribosomal small subunit biogenesis (GO:0042274)4.18222352
17CENP-A containing nucleosome assembly (GO:0034080)4.13783653
18mitotic metaphase plate congression (GO:0007080)4.12527956
19chromatin remodeling at centromere (GO:0031055)4.10839009
20translational elongation (GO:0006414)4.09541418
21DNA deamination (GO:0045006)4.06266500
22purine nucleobase biosynthetic process (GO:0009113)4.05136603
23mitotic recombination (GO:0006312)4.04626150
24DNA replication-dependent nucleosome assembly (GO:0006335)4.04211066
25DNA replication-dependent nucleosome organization (GO:0034723)4.04211066
26translational initiation (GO:0006413)3.99123846
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.98646374
28establishment of viral latency (GO:0019043)3.95077063
29kinetochore organization (GO:0051383)3.89191032
30ribonucleoprotein complex biogenesis (GO:0022613)3.88064778
31IMP biosynthetic process (GO:0006188)3.87998195
32DNA ligation (GO:0006266)3.86037033
33mitotic nuclear envelope disassembly (GO:0007077)3.85215994
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.78878585
35telomere maintenance via telomere lengthening (GO:0010833)3.78033634
36DNA replication-independent nucleosome organization (GO:0034724)3.77297082
37DNA replication-independent nucleosome assembly (GO:0006336)3.77297082
38ribosome assembly (GO:0042255)3.76798112
39spliceosomal snRNP assembly (GO:0000387)3.76378497
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.75695088
41protein localization to chromosome, centromeric region (GO:0071459)3.72773539
42cotranslational protein targeting to membrane (GO:0006613)3.70820321
43folic acid-containing compound biosynthetic process (GO:0009396)3.70760705
44ribosome biogenesis (GO:0042254)3.69465539
45protein targeting to ER (GO:0045047)3.68608674
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.66919032
47establishment of protein localization to mitochondrial membrane (GO:0090151)3.66100618
48chaperone-mediated protein transport (GO:0072321)3.63243035
49establishment of integrated proviral latency (GO:0075713)3.62402765
50proteasome assembly (GO:0043248)3.62280522
51metaphase plate congression (GO:0051310)3.62041524
52cellular protein complex disassembly (GO:0043624)3.61012128
53nuclear envelope disassembly (GO:0051081)3.56969221
54membrane disassembly (GO:0030397)3.56969221
55kinetochore assembly (GO:0051382)3.55761771
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.53374141
57negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.52100207
58anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.50596709
59rRNA processing (GO:0006364)3.49257052
60establishment of protein localization to endoplasmic reticulum (GO:0072599)3.49230953
61regulation of mitochondrial translation (GO:0070129)3.47648926
62histone exchange (GO:0043486)3.47286544
63protein localization to endoplasmic reticulum (GO:0070972)3.45282765
64mitotic sister chromatid segregation (GO:0000070)3.45238846
65* viral life cycle (GO:0019058)3.44086013
66regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.42171366
67IMP metabolic process (GO:0046040)3.39604076
68positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.37383650
69rRNA metabolic process (GO:0016072)3.36974522
70attachment of spindle microtubules to kinetochore (GO:0008608)3.35691073
71nuclear pore organization (GO:0006999)3.33893462
72regulation of spindle organization (GO:0090224)3.33493357
73mitotic spindle checkpoint (GO:0071174)3.32592999
74spliceosomal complex assembly (GO:0000245)3.32551855
75ATP synthesis coupled proton transport (GO:0015986)3.31642151
76energy coupled proton transport, down electrochemical gradient (GO:0015985)3.31642151
77establishment of chromosome localization (GO:0051303)3.30291074
78DNA damage response, detection of DNA damage (GO:0042769)3.28311412
79protein complex disassembly (GO:0043241)3.27607928
80translation (GO:0006412)3.25612184
81transcription-coupled nucleotide-excision repair (GO:0006283)3.25301497
82deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.24091385
83negative regulation of ligase activity (GO:0051352)3.23073888
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.23073888
85signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.22231425
86signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.22231425
87signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.22231425
88non-recombinational repair (GO:0000726)3.21156328
89double-strand break repair via nonhomologous end joining (GO:0006303)3.21156328
90G1/S transition of mitotic cell cycle (GO:0000082)3.20542136
91cell cycle G1/S phase transition (GO:0044843)3.20542136
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.19672465
93signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.19672465
94DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.19200006
95regulation of cellular amino acid metabolic process (GO:0006521)3.19159159
96regulation of chromosome segregation (GO:0051983)3.18649229
97regulation of ubiquitin-protein transferase activity (GO:0051438)3.18616238
98positive regulation of ligase activity (GO:0051351)3.17302776
99signal transduction involved in DNA damage checkpoint (GO:0072422)3.17058442
100signal transduction involved in DNA integrity checkpoint (GO:0072401)3.17058442
101rRNA modification (GO:0000154)3.15102896
102pseudouridine synthesis (GO:0001522)3.13608896
103sister chromatid segregation (GO:0000819)3.13456946
104signal transduction involved in cell cycle checkpoint (GO:0072395)3.13199002
105mitotic chromosome condensation (GO:0007076)3.13136225
106maturation of 5.8S rRNA (GO:0000460)3.12040994
107cullin deneddylation (GO:0010388)3.12035031
108macromolecular complex disassembly (GO:0032984)3.11826928
109DNA double-strand break processing (GO:0000729)3.09386214
110regulation of mitotic metaphase/anaphase transition (GO:0030071)3.07593451
111regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.07593451
112deoxyribonucleotide biosynthetic process (GO:0009263)3.07024991
113negative regulation of mitotic sister chromatid separation (GO:2000816)3.06741543
114negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06741543
115negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06741543
116negative regulation of sister chromatid segregation (GO:0033046)3.06741543
117regulation of ligase activity (GO:0051340)3.06562187
118negative regulation of chromosome segregation (GO:0051985)3.06042601
119DNA catabolic process, exonucleolytic (GO:0000738)3.05669606
120nuclear-transcribed mRNA catabolic process (GO:0000956)3.04409621
121negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.04402923
122nuclear pore complex assembly (GO:0051292)3.04077638
123L-serine metabolic process (GO:0006563)3.03977121
124spindle checkpoint (GO:0031577)3.03626693
125regulation of centrosome cycle (GO:0046605)3.02874853
126regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02173714
127spindle assembly checkpoint (GO:0071173)3.00104988
128negative regulation of RNA splicing (GO:0033119)2.99916642
129positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.99563372
130mitotic spindle assembly checkpoint (GO:0007094)2.98707749
131RNA splicing, via transesterification reactions (GO:0000375)2.97414446
132RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.97112866
133mRNA splicing, via spliceosome (GO:0000398)2.97112866
134negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96801699

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.64113191
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.73134225
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.12677141
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.02983093
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.84445008
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45079906
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.29075614
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.23590847
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.18817357
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.03755868
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.03084643
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.02617515
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.97973181
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90151568
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.86949277
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.68193544
17* XRN2_22483619_ChIP-Seq_HELA_Human2.56560199
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.48601705
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44209542
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.41426089
21VDR_23849224_ChIP-Seq_CD4+_Human2.26220639
22AR_21909140_ChIP-Seq_LNCAP_Human2.24501257
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24091746
24DCP1A_22483619_ChIP-Seq_HELA_Human2.16665141
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13332181
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.10467928
27TTF2_22483619_ChIP-Seq_HELA_Human2.05018502
28* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00981211
29E2F1_21310950_ChIP-Seq_MCF-7_Human2.00392671
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98285339
31FOXP3_21729870_ChIP-Seq_TREG_Human1.97998717
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.93257490
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92232037
34* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92040000
35GABP_19822575_ChIP-Seq_HepG2_Human1.91853727
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80948791
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76081129
38ELK1_19687146_ChIP-ChIP_HELA_Human1.74919978
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73331353
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71674314
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66124989
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66036044
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65401682
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.64254706
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64219540
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63222550
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58007168
48* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55080942
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.54744947
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52857711
51* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52480856
52CIITA_25753668_ChIP-Seq_RAJI_Human1.51251414
53KDM5A_27292631_Chip-Seq_BREAST_Human1.40547821
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40375372
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38058869
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35282985
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.34679763
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34487536
59* MYC_22102868_ChIP-Seq_BL_Human1.26152005
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25183148
61KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24960533
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22578995
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21089920
64SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18792442
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18347305
66NANOG_16153702_ChIP-ChIP_HESCs_Human1.17636992
67* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16593956
68* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16094971
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15991808
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.15710366
71* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15224226
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12051453
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10912686
74CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10370664
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.10095203
76* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08474249
77TFEB_21752829_ChIP-Seq_HELA_Human1.08226265
78MYC_18940864_ChIP-ChIP_HL60_Human1.08205158
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.07865560
80* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06844755
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06112180
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05360865
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04915360
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02798484
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02024545
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00254542
87* SOX17_20123909_ChIP-Seq_XEN_Mouse0.98804131
88* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98501580
89* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98258300
90ELK1_22589737_ChIP-Seq_MCF10A_Human0.98198361
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95552736
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95420897
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94740220
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93616461
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93332577
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91651165
97ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91260134
98NOTCH1_21737748_ChIP-Seq_TLL_Human0.89588367
99TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86000485
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85242231
101OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83949515
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83306381
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82470454
104* EWS_26573619_Chip-Seq_HEK293_Human0.82470221
105SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80703989
106NANOG_21062744_ChIP-ChIP_HESCs_Human0.79614941
107* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79478499
108TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79001855
109SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.77557555
110VDR_21846776_ChIP-Seq_THP-1_Human0.77317081
111ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.75783077
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.74607854
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74499664
114NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72632744
115ZNF263_19887448_ChIP-Seq_K562_Human0.69339132
116CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69260886
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.68407500

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.67360944
2MP0004957_abnormal_blastocyst_morpholog4.90709145
3MP0010094_abnormal_chromosome_stability4.88364137
4MP0003111_abnormal_nucleus_morphology4.70083392
5MP0003077_abnormal_cell_cycle4.24785425
6MP0008057_abnormal_DNA_replication3.72177217
7MP0008058_abnormal_DNA_repair3.42662300
8MP0008007_abnormal_cellular_replicative3.18067838
9MP0008932_abnormal_embryonic_tissue3.17340289
10MP0003123_paternal_imprinting2.86863345
11MP0001730_embryonic_growth_arrest2.50982641
12MP0000350_abnormal_cell_proliferation2.37335378
13MP0009697_abnormal_copulation2.32059991
14MP0008877_abnormal_DNA_methylation2.14767797
15MP0003786_premature_aging2.11341317
16MP0010030_abnormal_orbit_morphology2.06049180
17MP0010352_gastrointestinal_tract_polyps2.00398554
18MP0002396_abnormal_hematopoietic_system1.87441120
19MP0001697_abnormal_embryo_size1.87379519
20MP0009379_abnormal_foot_pigmentation1.78154951
21MP0005380_embryogenesis_phenotype1.76702223
22MP0001672_abnormal_embryogenesis/_devel1.76702223
23MP0001529_abnormal_vocalization1.74228926
24MP0002080_prenatal_lethality1.71113283
25MP0010307_abnormal_tumor_latency1.69693089
26MP0002085_abnormal_embryonic_tissue1.63664201
27MP0003984_embryonic_growth_retardation1.57781889
28MP0000490_abnormal_crypts_of1.56721180
29MP0002088_abnormal_embryonic_growth/wei1.54099816
30MP0000313_abnormal_cell_death1.50458259
31MP0003718_maternal_effect1.50176892
32MP0002084_abnormal_developmental_patter1.49956706
33MP0003121_genomic_imprinting1.48671257
34MP0004197_abnormal_fetal_growth/weight/1.45625504
35MP0004808_abnormal_hematopoietic_stem1.41852927
36MP0000537_abnormal_urethra_morphology1.41094805
37MP0003315_abnormal_perineum_morphology1.39647405
38MP0003806_abnormal_nucleotide_metabolis1.36673896
39MP0002019_abnormal_tumor_incidence1.34056668
40MP0002086_abnormal_extraembryonic_tissu1.32706984
41MP0003567_abnormal_fetal_cardiomyocyte1.32302120
42MP0009053_abnormal_anal_canal1.30777329
43MP0001293_anophthalmia1.29823696
44MP0002210_abnormal_sex_determination1.26823372
45MP0004133_heterotaxia1.24033273
46MP0002697_abnormal_eye_size1.20331160
47MP0006072_abnormal_retinal_apoptosis1.19813838
48MP0003890_abnormal_embryonic-extraembry1.17330098
49MP0005499_abnormal_olfactory_system1.15152801
50MP0005394_taste/olfaction_phenotype1.15152801
51MP0002160_abnormal_reproductive_system1.15133084
52MP0001145_abnormal_male_reproductive1.12856947
53MP0001346_abnormal_lacrimal_gland1.10961221
54MP0006054_spinal_hemorrhage1.08574220
55MP0000358_abnormal_cell_content/1.07424848
56MP0009333_abnormal_splenocyte_physiolog1.06516454
57MP0003119_abnormal_digestive_system1.04669861
58MP0003941_abnormal_skin_development1.00763598
59MP0002233_abnormal_nose_morphology1.00638246
60MP0005076_abnormal_cell_differentiation1.00223260
61MP0002102_abnormal_ear_morphology0.98116284
62MP0002234_abnormal_pharynx_morphology0.97268297
63MP0002111_abnormal_tail_morphology0.96218957
64MP0003186_abnormal_redox_activity0.95401339
65MP0008995_early_reproductive_senescence0.95369325
66MP0001929_abnormal_gametogenesis0.93910470
67MP0000653_abnormal_sex_gland0.92184684
68MP0000703_abnormal_thymus_morphology0.90530054
69MP0005397_hematopoietic_system_phenotyp0.88202635
70MP0001545_abnormal_hematopoietic_system0.88202635
71MP0000579_abnormal_nail_morphology0.85542377
72MP0003937_abnormal_limbs/digits/tail_de0.85416701
73MP0005389_reproductive_system_phenotype0.84865216
74MP0009672_abnormal_birth_weight0.84457409
75MP0004147_increased_porphyrin_level0.84443181
76MP0000858_altered_metastatic_potential0.83336935
77MP0000647_abnormal_sebaceous_gland0.83172795
78MP0003136_yellow_coat_color0.82428594
79MP0002653_abnormal_ependyma_morphology0.82353119
80MP0006292_abnormal_olfactory_placode0.81496155
81MP0003221_abnormal_cardiomyocyte_apopto0.81364092
82MP0005384_cellular_phenotype0.78829660
83MP0002938_white_spotting0.76694879
84MP0000372_irregular_coat_pigmentation0.76490347
85MP0000049_abnormal_middle_ear0.76018959
86MP0005501_abnormal_skin_physiology0.75994661
87MP0001188_hyperpigmentation0.75639625
88MP0006035_abnormal_mitochondrial_morpho0.75545073
89MP0002132_abnormal_respiratory_system0.74669596
90MP0002722_abnormal_immune_system0.73307023
91MP0006036_abnormal_mitochondrial_physio0.71911624
92MP0000428_abnormal_craniofacial_morphol0.71242653
93MP0001286_abnormal_eye_development0.70904196
94MP0001119_abnormal_female_reproductive0.69823816
95MP0000566_synostosis0.69203159
96MP0002398_abnormal_bone_marrow0.67341581
97MP0003755_abnormal_palate_morphology0.67289842
98MP0000689_abnormal_spleen_morphology0.66488648
99MP0001881_abnormal_mammary_gland0.65630160
100MP0005621_abnormal_cell_physiology0.64398132
101MP0000750_abnormal_muscle_regeneration0.64227995
102MP0001915_intracranial_hemorrhage0.63903444
103MP0005391_vision/eye_phenotype0.63759137
104MP0002796_impaired_skin_barrier0.63100999
105MP0002736_abnormal_nociception_after0.62765485
106MP0001919_abnormal_reproductive_system0.62668921
107MP0005023_abnormal_wound_healing0.62667072
108MP0002751_abnormal_autonomic_nervous0.62599629
109MP0005395_other_phenotype0.62185774
110MP0003698_abnormal_male_reproductive0.61891644
111MP0002161_abnormal_fertility/fecundity0.61684610
112MP0002282_abnormal_trachea_morphology0.60953455
113MP0003942_abnormal_urinary_system0.60247626
114MP0000762_abnormal_tongue_morphology0.59500593
115MP0003763_abnormal_thymus_physiology0.58791625
116MP0002092_abnormal_eye_morphology0.58333272
117MP0008789_abnormal_olfactory_epithelium0.57837408
118MP0003699_abnormal_female_reproductive0.57228187
119MP0009703_decreased_birth_body0.56514091
120MP0001727_abnormal_embryo_implantation0.56114394
121MP0002095_abnormal_skin_pigmentation0.55906679
122MP0002114_abnormal_axial_skeleton0.55775139
123MP0002163_abnormal_gland_morphology0.55493879
124MP0003861_abnormal_nervous_system0.55491901
125MP0005266_abnormal_metabolism0.55404594
126MP0001764_abnormal_homeostasis0.55368494
127MP0002429_abnormal_blood_cell0.53834431
128MP0003115_abnormal_respiratory_system0.52791813
129MP0000432_abnormal_head_morphology0.52545729
130MP0002932_abnormal_joint_morphology0.51893188

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.94198819
2Reticulocytopenia (HP:0001896)4.81269499
3Abnormality of cells of the erythroid lineage (HP:0012130)4.67562182
4Abnormal number of erythroid precursors (HP:0012131)4.45261893
5Breast hypoplasia (HP:0003187)3.98800565
6Colon cancer (HP:0003003)3.81629916
7Oral leukoplakia (HP:0002745)3.76909247
8Acute necrotizing encephalopathy (HP:0006965)3.60749621
9Abnormality of the anterior horn cell (HP:0006802)3.59740748
10Degeneration of anterior horn cells (HP:0002398)3.59740748
11Selective tooth agenesis (HP:0001592)3.47231790
12Macrocytic anemia (HP:0001972)3.44540131
13Increased hepatocellular lipid droplets (HP:0006565)3.39350868
14Abnormal mitochondria in muscle tissue (HP:0008316)3.38333380
15Acute encephalopathy (HP:0006846)3.37267089
16Patellar aplasia (HP:0006443)3.29272289
17Carpal bone hypoplasia (HP:0001498)3.24758417
18Rough bone trabeculation (HP:0100670)3.16137092
19Pallor (HP:0000980)3.15903842
20Aplasia/Hypoplasia of the patella (HP:0006498)3.10991689
21Medulloblastoma (HP:0002885)3.09627012
22Aplastic anemia (HP:0001915)3.06703847
23Mitochondrial inheritance (HP:0001427)3.03342625
24Chromsome breakage (HP:0040012)3.00390512
25Lipid accumulation in hepatocytes (HP:0006561)2.99507806
26Meckel diverticulum (HP:0002245)2.90015730
27Cerebral hypomyelination (HP:0006808)2.80846016
28Ependymoma (HP:0002888)2.79570000
29Progressive macrocephaly (HP:0004481)2.78831130
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.76599537
31Trismus (HP:0000211)2.75819199
32Abnormality of the ileum (HP:0001549)2.75290262
33Hepatocellular necrosis (HP:0001404)2.73007167
34Abnormality of chromosome stability (HP:0003220)2.71497909
35Cerebral edema (HP:0002181)2.70982210
36Abnormality of the preputium (HP:0100587)2.70291017
37Agnosia (HP:0010524)2.69433811
38Absent thumb (HP:0009777)2.68826336
3911 pairs of ribs (HP:0000878)2.66958427
40Abnormal number of incisors (HP:0011064)2.65905336
41Absent radius (HP:0003974)2.63808460
42Neoplasm of the pancreas (HP:0002894)2.61380163
43Premature graying of hair (HP:0002216)2.61141952
44Microretrognathia (HP:0000308)2.57726476
45Abnormal lung lobation (HP:0002101)2.50168090
46Cortical dysplasia (HP:0002539)2.49784814
47Hepatic necrosis (HP:0002605)2.48275035
48Absent forearm bone (HP:0003953)2.45910281
49Aplasia involving forearm bones (HP:0009822)2.45910281
50Duodenal stenosis (HP:0100867)2.45386940
51Small intestinal stenosis (HP:0012848)2.45386940
52Abnormality of the labia minora (HP:0012880)2.45110484
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.44943146
54Rhabdomyosarcoma (HP:0002859)2.44103896
55Horseshoe kidney (HP:0000085)2.42553992
56Aplasia/Hypoplasia of the sacrum (HP:0008517)2.42439438
57Multiple enchondromatosis (HP:0005701)2.40584401
58Abnormality of methionine metabolism (HP:0010901)2.40070319
59Atresia of the external auditory canal (HP:0000413)2.37830025
60Myelodysplasia (HP:0002863)2.34183787
61Triphalangeal thumb (HP:0001199)2.29704616
62Glossoptosis (HP:0000162)2.27764944
63Supernumerary spleens (HP:0009799)2.26847572
64Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.25163253
65Abnormality of the carotid arteries (HP:0005344)2.24477189
66Lactic acidosis (HP:0003128)2.24174011
67Embryonal renal neoplasm (HP:0011794)2.23315489
68Abnormal trabecular bone morphology (HP:0100671)2.21607454
69Renal Fanconi syndrome (HP:0001994)2.21147839
70Cleft eyelid (HP:0000625)2.18842987
71Type I transferrin isoform profile (HP:0003642)2.18500675
72Abnormality of glycolysis (HP:0004366)2.16471263
73Increased serum pyruvate (HP:0003542)2.16471263
74Tracheoesophageal fistula (HP:0002575)2.15031120
75Atrophy/Degeneration involving motor neurons (HP:0007373)2.14707239
76Cellular immunodeficiency (HP:0005374)2.14368849
77Exercise intolerance (HP:0003546)2.14163309
78Slender long bone (HP:0003100)2.14031543
79Basal cell carcinoma (HP:0002671)2.13553843
80Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11868863
81Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11868863
82Impulsivity (HP:0100710)2.11559984
83Bone marrow hypocellularity (HP:0005528)2.10908484
84Hypoplasia of the capital femoral epiphysis (HP:0003090)2.10457510
85Sloping forehead (HP:0000340)2.10205919
86Increased intramyocellular lipid droplets (HP:0012240)2.09281467
87Abnormality of abdominal situs (HP:0011620)2.07390244
88Abdominal situs inversus (HP:0003363)2.07390244
89Secondary amenorrhea (HP:0000869)2.06935457
90Proximal placement of thumb (HP:0009623)2.06502029
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05532854
92Abnormality of alanine metabolism (HP:0010916)2.05532854
93Hyperalaninemia (HP:0003348)2.05532854
94Missing ribs (HP:0000921)2.04554265
95Megaloblastic anemia (HP:0001889)2.04277669
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04140786
97Leukodystrophy (HP:0002415)2.03205754
98Abnormality of serum amino acid levels (HP:0003112)2.02695556
99Abnormality of the duodenum (HP:0002246)2.01651383
100Neoplasm of the colon (HP:0100273)2.01491852
101Increased nuchal translucency (HP:0010880)1.99737034
102Increased serum lactate (HP:0002151)1.99005829
103Deviation of the thumb (HP:0009603)1.98107944
104Respiratory difficulties (HP:0002880)1.93711011
105Aplasia/Hypoplasia of the sternum (HP:0006714)1.91405946
106Premature ovarian failure (HP:0008209)1.91384584
107Progressive muscle weakness (HP:0003323)1.90729252
108Hypoplastic pelvis (HP:0008839)1.90132765
109Abnormality of reticulocytes (HP:0004312)1.89103707
1103-Methylglutaconic aciduria (HP:0003535)1.85574938
111Irregular epiphyses (HP:0010582)1.84615090
112Reduced antithrombin III activity (HP:0001976)1.84012792
113Squamous cell carcinoma (HP:0002860)1.83564341
114Respiratory failure (HP:0002878)1.83280071
115Facial cleft (HP:0002006)1.82997281
116Ectopic kidney (HP:0000086)1.81107747
117Angiofibromas (HP:0010615)1.80761743
118Adenoma sebaceum (HP:0009720)1.80761743
119Clubbing of toes (HP:0100760)1.78952989
120Hypoplasia of the radius (HP:0002984)1.78788243
121Pancytopenia (HP:0001876)1.78317660
122Hyperglycinemia (HP:0002154)1.76937460
123Hypoplasia of the pons (HP:0012110)1.74737884
124Choanal atresia (HP:0000453)1.74718440
125Increased CSF lactate (HP:0002490)1.73426249
126Nephroblastoma (Wilms tumor) (HP:0002667)1.73325759
127Abnormality of the umbilical cord (HP:0010881)1.72769424
128Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72229249
129Thrombocytosis (HP:0001894)1.71948009
130Neoplasm of striated muscle (HP:0009728)1.71306750
131Short thumb (HP:0009778)1.71295349
132Sparse eyelashes (HP:0000653)1.71180492
133Abnormality of the calcaneus (HP:0008364)1.71133776
134Abnormality of the septum pellucidum (HP:0007375)1.71074370
135Abnormal glycosylation (HP:0012345)1.70345191
136Abnormal protein N-linked glycosylation (HP:0012347)1.70345191
137Abnormal protein glycosylation (HP:0012346)1.70345191
138Aplasia/hypoplasia of the humerus (HP:0006507)1.69469890
139Cafe-au-lait spot (HP:0000957)1.69314375
140Microvesicular hepatic steatosis (HP:0001414)1.69151320
141Postnatal microcephaly (HP:0005484)1.68758427
142Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.68727695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.44552981
2WEE14.60431565
3CDC74.08327517
4EIF2AK13.88212831
5VRK23.40054393
6SRPK12.74745386
7NME22.68731598
8NEK22.46619742
9NEK12.36768585
10TSSK62.32320639
11TESK22.30791293
12TTK2.22895727
13STK162.21007448
14TLK12.19009941
15PLK42.09605650
16VRK12.06844398
17BRSK22.05973625
18MKNK11.95950657
19EIF2AK31.95040292
20* PLK11.85905951
21ACVR1B1.80264207
22PASK1.79318316
23AURKB1.68980441
24PLK31.66821494
25TAF11.62995194
26CDK71.61456770
27TRIM281.59927753
28RPS6KB21.53476201
29DYRK31.52641021
30ATR1.52631924
31RPS6KA41.50816242
32BRSK11.45799227
33AURKA1.43872921
34SCYL21.43672817
35TESK11.40420706
36MAP3K81.32318665
37MKNK21.30289191
38CHEK21.29159071
39CCNB11.26798331
40NUAK11.21783638
41TGFBR11.19426100
42PBK1.18897619
43EPHA21.13915225
44CHEK11.10034970
45CDK41.06067388
46NME10.99580242
47PIM20.97689748
48STK40.90882535
49ZAK0.89688946
50PNCK0.88738177
51CDK80.88476095
52PDK20.88039534
53KDR0.87964563
54LIMK10.87675031
55STK100.87090609
56EEF2K0.85285404
57BCR0.79710874
58WNK30.79528061
59ATM0.76401654
60CSNK1G30.75764124
61PAK10.75697400
62CSNK2A20.75177461
63CSNK1G10.74824190
64LRRK20.74804723
65CDK20.74745507
66EIF2AK20.73502203
67MAP3K110.72630604
68CSNK2A10.72435377
69BRAF0.70191396
70SMG10.67208818
71MAP3K100.66374397
72PKN20.62935767
73ERBB40.60019926
74ALK0.59144316
75CDK10.58454870
76CSNK1A1L0.57227412
77MAP3K120.56178176
78PIM10.55835383
79CSNK1G20.54397777
80CDK60.53998544
81TNIK0.53086181
82FLT30.52988049
83PLK20.51993101
84MELK0.49745396
85ERBB30.49000025
86RPS6KA50.48945257
87TAOK20.48786094
88ILK0.47107034
89BMPR1B0.44808963
90PRKCI0.44048347
91DYRK20.43381756
92LATS20.43349919
93MAPKAPK30.42020113
94CDK120.41485371
95MAP2K70.37149932
96CDK140.35839944
97MINK10.35243829
98MST1R0.35046911
99CSNK1E0.33623518
100CDK11A0.33493773
101AKT20.33442853
102MAP2K30.32873026
103MAP4K20.32112071
104ABL20.31047748
105CLK10.30880567
106CDK30.30827502
107PRKDC0.30357168
108CDK150.30066662
109CDK180.30042894
110PDK40.29256751
111PDK30.29256751
112CDK90.28368805
113NEK90.27600908
114PAK20.23659879
115YES10.21823568
116FGFR10.21297595
117BRD40.20992956
118CDK190.20541609
119STK38L0.20487174
120STK30.19598886
121MST40.18992382
122BCKDK0.18588288
123DAPK10.17549520
124MAPKAPK20.14032537

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.16568753
2Mismatch repair_Homo sapiens_hsa034304.36194826
3Ribosome_Homo sapiens_hsa030104.18371124
4Proteasome_Homo sapiens_hsa030503.88392202
5Spliceosome_Homo sapiens_hsa030403.51134445
6* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.46133075
7RNA polymerase_Homo sapiens_hsa030203.32981599
8* RNA transport_Homo sapiens_hsa030133.06942226
9Homologous recombination_Homo sapiens_hsa034403.04165828
10Base excision repair_Homo sapiens_hsa034103.00027257
11Nucleotide excision repair_Homo sapiens_hsa034202.99374220
12Cell cycle_Homo sapiens_hsa041102.71119382
13One carbon pool by folate_Homo sapiens_hsa006702.69025772
14Pyrimidine metabolism_Homo sapiens_hsa002402.62118975
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.48936712
16Fanconi anemia pathway_Homo sapiens_hsa034602.11806449
17Non-homologous end-joining_Homo sapiens_hsa034501.92970291
18RNA degradation_Homo sapiens_hsa030181.84906419
19Basal transcription factors_Homo sapiens_hsa030221.84256252
20mRNA surveillance pathway_Homo sapiens_hsa030151.64984179
21p53 signaling pathway_Homo sapiens_hsa041151.52291946
22Purine metabolism_Homo sapiens_hsa002301.36740457
23Systemic lupus erythematosus_Homo sapiens_hsa053221.25021234
24Propanoate metabolism_Homo sapiens_hsa006401.16449414
25* Epstein-Barr virus infection_Homo sapiens_hsa051691.15768291
26Parkinsons disease_Homo sapiens_hsa050121.11067494
27Fatty acid elongation_Homo sapiens_hsa000621.10435398
28Steroid biosynthesis_Homo sapiens_hsa001001.09668654
29Oocyte meiosis_Homo sapiens_hsa041141.09260115
30Huntingtons disease_Homo sapiens_hsa050161.07678744
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98160597
32Protein export_Homo sapiens_hsa030600.95425652
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93688827
34Cysteine and methionine metabolism_Homo sapiens_hsa002700.91028217
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90881804
36Biosynthesis of amino acids_Homo sapiens_hsa012300.88892604
37Oxidative phosphorylation_Homo sapiens_hsa001900.88833876
38Viral carcinogenesis_Homo sapiens_hsa052030.87765076
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85428152
40Cyanoamino acid metabolism_Homo sapiens_hsa004600.85075134
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77055718
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76989711
43Pentose phosphate pathway_Homo sapiens_hsa000300.73946252
44Herpes simplex infection_Homo sapiens_hsa051680.71276690
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69215118
46Antigen processing and presentation_Homo sapiens_hsa046120.68321673
47Folate biosynthesis_Homo sapiens_hsa007900.66500667
48Sulfur relay system_Homo sapiens_hsa041220.66023985
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65503597
50* HTLV-I infection_Homo sapiens_hsa051660.63905996
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63444205
52Selenocompound metabolism_Homo sapiens_hsa004500.59905781
53Carbon metabolism_Homo sapiens_hsa012000.57861702
54Thyroid cancer_Homo sapiens_hsa052160.57767056
55Glutathione metabolism_Homo sapiens_hsa004800.56750390
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.55154076
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54370934
58Alcoholism_Homo sapiens_hsa050340.54166934
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50241120
60Legionellosis_Homo sapiens_hsa051340.49744067
61MicroRNAs in cancer_Homo sapiens_hsa052060.48152735
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47828936
63Vitamin B6 metabolism_Homo sapiens_hsa007500.45507408
64Small cell lung cancer_Homo sapiens_hsa052220.45333654
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42054150
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41577222
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41454291
68Hippo signaling pathway_Homo sapiens_hsa043900.40500700
69Bladder cancer_Homo sapiens_hsa052190.40358985
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39928609
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39911322
72Alzheimers disease_Homo sapiens_hsa050100.39800561
73N-Glycan biosynthesis_Homo sapiens_hsa005100.39778373
74TGF-beta signaling pathway_Homo sapiens_hsa043500.39163922
75Arginine and proline metabolism_Homo sapiens_hsa003300.38078567
76Basal cell carcinoma_Homo sapiens_hsa052170.37398546
77Sulfur metabolism_Homo sapiens_hsa009200.34452065
78Shigellosis_Homo sapiens_hsa051310.33095694
79Fatty acid metabolism_Homo sapiens_hsa012120.32878967
80Apoptosis_Homo sapiens_hsa042100.30506332
81Colorectal cancer_Homo sapiens_hsa052100.29964955
82HIF-1 signaling pathway_Homo sapiens_hsa040660.28724608
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25987792
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25239692
85Fructose and mannose metabolism_Homo sapiens_hsa000510.24811737
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24230714
87Metabolic pathways_Homo sapiens_hsa011000.24096474
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.23950027
89Hedgehog signaling pathway_Homo sapiens_hsa043400.23784449
90Peroxisome_Homo sapiens_hsa041460.23759464
91Hepatitis B_Homo sapiens_hsa051610.23107173
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22372250
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22006775
94Butanoate metabolism_Homo sapiens_hsa006500.18687657
95Vitamin digestion and absorption_Homo sapiens_hsa049770.18244630
96Pathways in cancer_Homo sapiens_hsa052000.17301900
97Galactose metabolism_Homo sapiens_hsa000520.14854034
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14775490
99Viral myocarditis_Homo sapiens_hsa054160.13409355
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13279373
101Lysine degradation_Homo sapiens_hsa003100.12774035
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12525034
103Chronic myeloid leukemia_Homo sapiens_hsa052200.12145638
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11895810
105Melanoma_Homo sapiens_hsa052180.11812328
106Renin-angiotensin system_Homo sapiens_hsa046140.10928311
107beta-Alanine metabolism_Homo sapiens_hsa004100.10416980
108Arginine biosynthesis_Homo sapiens_hsa002200.09882422
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.09714697
110Measles_Homo sapiens_hsa051620.09255941
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.09201119
112Notch signaling pathway_Homo sapiens_hsa043300.08825140
113Wnt signaling pathway_Homo sapiens_hsa043100.07480671
114Fatty acid degradation_Homo sapiens_hsa000710.06901102
115Cardiac muscle contraction_Homo sapiens_hsa042600.06798167
116Primary immunodeficiency_Homo sapiens_hsa053400.06076278
117Pyruvate metabolism_Homo sapiens_hsa006200.05018330
118Tyrosine metabolism_Homo sapiens_hsa003500.04994828
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.04573422
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.03403128
121Tight junction_Homo sapiens_hsa045300.02080577
122Phenylalanine metabolism_Homo sapiens_hsa00360-0.0068391

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