RANBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.07017879
2ribosomal small subunit assembly (GO:0000028)4.91041653
3telomere maintenance via semi-conservative replication (GO:0032201)4.81605808
4DNA strand elongation (GO:0022616)4.81243688
5DNA unwinding involved in DNA replication (GO:0006268)4.80430093
6DNA replication initiation (GO:0006270)4.73591700
7DNA deamination (GO:0045006)4.70173978
8viral transcription (GO:0019083)4.68235478
9maturation of SSU-rRNA (GO:0030490)4.66278803
10translational termination (GO:0006415)4.61002835
11formation of translation preinitiation complex (GO:0001731)4.37119440
12ribosomal small subunit biogenesis (GO:0042274)4.34043468
13nuclear pore complex assembly (GO:0051292)4.28753259
14telomere maintenance via recombination (GO:0000722)4.26106314
15ribosomal large subunit biogenesis (GO:0042273)4.25511942
16translational elongation (GO:0006414)4.19486555
17mitotic chromosome condensation (GO:0007076)4.14279290
18DNA replication checkpoint (GO:0000076)4.07814650
19translational initiation (GO:0006413)4.07713357
20nucleobase biosynthetic process (GO:0046112)4.07079653
21mitotic recombination (GO:0006312)4.05006966
22regulation of mitochondrial translation (GO:0070129)3.96038498
23DNA replication-dependent nucleosome assembly (GO:0006335)3.95536297
24DNA replication-dependent nucleosome organization (GO:0034723)3.95536297
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.94345142
26protein localization to kinetochore (GO:0034501)3.92489578
27sister chromatid segregation (GO:0000819)3.90752567
28negative regulation of mRNA processing (GO:0050686)3.90563351
29ribonucleoprotein complex biogenesis (GO:0022613)3.89936460
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.87963591
31CENP-A containing nucleosome assembly (GO:0034080)3.87811560
32chromatin remodeling at centromere (GO:0031055)3.87347154
33telomere maintenance via telomere lengthening (GO:0010833)3.86204608
34cotranslational protein targeting to membrane (GO:0006613)3.84223491
35protein targeting to ER (GO:0045047)3.83360925
36mitotic metaphase plate congression (GO:0007080)3.80293951
37regulation of translational fidelity (GO:0006450)3.79372770
38spliceosomal snRNP assembly (GO:0000387)3.77505229
39purine nucleobase biosynthetic process (GO:0009113)3.77227301
40nucleotide-excision repair, DNA gap filling (GO:0006297)3.74284097
41establishment of integrated proviral latency (GO:0075713)3.71852390
42folic acid-containing compound biosynthetic process (GO:0009396)3.69329226
43ribosome assembly (GO:0042255)3.68628697
44cellular protein complex disassembly (GO:0043624)3.67316196
45ribosome biogenesis (GO:0042254)3.66656300
46proteasome assembly (GO:0043248)3.65181974
47mitotic nuclear envelope disassembly (GO:0007077)3.63398490
48kinetochore organization (GO:0051383)3.63374196
49viral life cycle (GO:0019058)3.63256194
50establishment of protein localization to endoplasmic reticulum (GO:0072599)3.62517750
51protein localization to endoplasmic reticulum (GO:0070972)3.60094125
52DNA replication-independent nucleosome assembly (GO:0006336)3.58016214
53DNA replication-independent nucleosome organization (GO:0034724)3.58016214
54IMP biosynthetic process (GO:0006188)3.57588645
55nucleobase-containing small molecule interconversion (GO:0015949)3.57152314
56heterochromatin organization (GO:0070828)3.56866481
57rRNA processing (GO:0006364)3.53419099
58regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.48518021
59negative regulation of mRNA metabolic process (GO:1903312)3.46615548
60DNA topological change (GO:0006265)3.46092144
61deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.41285149
62rRNA metabolic process (GO:0016072)3.41188490
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.39673419
64protein localization to chromosome, centromeric region (GO:0071459)3.37483524
65protein complex disassembly (GO:0043241)3.35894375
66spliceosomal complex assembly (GO:0000245)3.35462088
67kinetochore assembly (GO:0051382)3.35299627
68nuclear envelope disassembly (GO:0051081)3.34474789
69membrane disassembly (GO:0030397)3.34474789
70translation (GO:0006412)3.33387835
71metaphase plate congression (GO:0051310)3.32363008
72pseudouridine synthesis (GO:0001522)3.32110028
73anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.31294657
74regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.25195203
75transcription-coupled nucleotide-excision repair (GO:0006283)3.25144531
76pore complex assembly (GO:0046931)3.24437359
77positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.20859483
78mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.19871678
79macromolecular complex disassembly (GO:0032984)3.19633825
80pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.19582737
81histone exchange (GO:0043486)3.18103225
82pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.17958031
83negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.15710089
84nuclear-transcribed mRNA catabolic process (GO:0000956)3.15478166
85viral mRNA export from host cell nucleus (GO:0046784)3.14781935
86nuclear pore organization (GO:0006999)3.13393870
87establishment of viral latency (GO:0019043)3.13363366
88negative regulation of ligase activity (GO:0051352)3.12638682
89negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.12638682
90IMP metabolic process (GO:0046040)3.12002684
91protein complex localization (GO:0031503)3.11811315
92negative regulation of RNA splicing (GO:0033119)3.10797365
93G1/S transition of mitotic cell cycle (GO:0000082)3.08933693
94cell cycle G1/S phase transition (GO:0044843)3.08933693
95mitotic sister chromatid segregation (GO:0000070)3.08171538
96RNA splicing, via transesterification reactions (GO:0000375)3.06749288
97regulation of translational termination (GO:0006449)3.06172542
98mRNA splicing, via spliceosome (GO:0000398)3.05875367
99RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.05875367
100establishment of chromosome localization (GO:0051303)3.04699220
101maturation of 5.8S rRNA (GO:0000460)3.00884283
102peptidyl-arginine omega-N-methylation (GO:0035247)3.00761407
103regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.00230900
104exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.98575915
105mRNA catabolic process (GO:0006402)2.98508890
106RNA catabolic process (GO:0006401)2.96248233
107termination of RNA polymerase II transcription (GO:0006369)2.95256058
108cellular component biogenesis (GO:0044085)2.94270082
109deoxyribonucleotide biosynthetic process (GO:0009263)2.94261866
110DNA ligation (GO:0006266)2.93885400
111DNA duplex unwinding (GO:0032508)2.93639809
112pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.93429495
113DNA geometric change (GO:0032392)2.92525272
114chromatin assembly (GO:0031497)2.92496901
115negative regulation of chromosome segregation (GO:0051985)2.89714600
116negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88518432
117negative regulation of sister chromatid segregation (GO:0033046)2.88518432
118negative regulation of mitotic sister chromatid separation (GO:2000816)2.88518432
119negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88518432
120attachment of spindle microtubules to kinetochore (GO:0008608)2.87275735
121chromatin assembly or disassembly (GO:0006333)2.87243954
122telomere organization (GO:0032200)2.87224125
123DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.87018087

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.39957380
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.65982204
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.09073927
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.71633948
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.64966301
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26762530
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.20424134
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.10427109
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08430686
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.01237248
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.99952622
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.97120910
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.92019811
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84610368
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.75112930
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.57964554
17XRN2_22483619_ChIP-Seq_HELA_Human2.56488899
18* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45086274
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36567962
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.25792433
21* VDR_23849224_ChIP-Seq_CD4+_Human2.21710524
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13654969
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09009768
24AR_21909140_ChIP-Seq_LNCAP_Human2.07191411
25* DCP1A_22483619_ChIP-Seq_HELA_Human2.07132229
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06640652
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04587491
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97337691
29* TTF2_22483619_ChIP-Seq_HELA_Human1.95884288
30FOXP3_21729870_ChIP-Seq_TREG_Human1.95559377
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.95365167
32GABP_19822575_ChIP-Seq_HepG2_Human1.90557456
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90324234
34* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86000717
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84869817
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74892992
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72730602
38ELK1_19687146_ChIP-ChIP_HELA_Human1.68668044
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68266022
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66795927
41* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66601007
42* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64195911
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.61727142
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.57601658
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56147136
46CIITA_25753668_ChIP-Seq_RAJI_Human1.52972554
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52456823
48MYC_22102868_ChIP-Seq_BL_Human1.49835796
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49560081
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.47939494
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46616385
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42803525
53* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39591953
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39321771
55KDM5A_27292631_Chip-Seq_BREAST_Human1.39070653
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36958194
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.33714318
58ZNF263_19887448_ChIP-Seq_K562_Human1.30520886
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30178720
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27556823
61KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26738760
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24124133
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23789550
64SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22904958
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22818660
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22689003
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.22044610
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21159570
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21014066
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19262133
71* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15042692
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14882664
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14414145
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12913812
75TFEB_21752829_ChIP-Seq_HELA_Human1.11970005
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09979785
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09316162
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06513736
79MYC_18940864_ChIP-ChIP_HL60_Human1.05882685
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05161627
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04156836
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03756186
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.02103290
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98088560
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97938980
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96893376
87VDR_21846776_ChIP-Seq_THP-1_Human0.96582316
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95938921
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95496414
90TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94458243
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94060589
92NOTCH1_21737748_ChIP-Seq_TLL_Human0.93507349
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92839155
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91902694
95* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91898193
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91873419
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91211664
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91148729
99* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90629557
100CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90512354
101CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89222023
102* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87959456
103* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87813015
104SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86189801
105* FOXP1_21924763_ChIP-Seq_HESCs_Human0.85988845
106TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84066347
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83025736
108CHD1_26751641_Chip-Seq_LNCaP_Human0.82801322
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.82617666
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81642292
111SPI1_23547873_ChIP-Seq_NB4_Human0.81281377
112* NCOR1_26117541_ChIP-Seq_K562_Human0.80779709
113CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80388317
114NANOG_21062744_ChIP-ChIP_HESCs_Human0.77566670

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.52965335
2MP0004957_abnormal_blastocyst_morpholog4.70473062
3MP0010094_abnormal_chromosome_stability4.51398386
4MP0003111_abnormal_nucleus_morphology4.36111788
5MP0003077_abnormal_cell_cycle4.04629343
6MP0008057_abnormal_DNA_replication3.58212077
7MP0008058_abnormal_DNA_repair3.17914071
8MP0008007_abnormal_cellular_replicative3.04368090
9MP0008932_abnormal_embryonic_tissue3.01432091
10MP0003123_paternal_imprinting2.79322560
11MP0001730_embryonic_growth_arrest2.40688237
12MP0000350_abnormal_cell_proliferation2.30749964
13MP0010030_abnormal_orbit_morphology2.19980711
14MP0010352_gastrointestinal_tract_polyps2.17107043
15MP0002396_abnormal_hematopoietic_system2.13270244
16MP0009697_abnormal_copulation2.08214088
17MP0003786_premature_aging1.91929699
18MP0002877_abnormal_melanocyte_morpholog1.83401208
19MP0001697_abnormal_embryo_size1.81425110
20MP0000490_abnormal_crypts_of1.77966016
21MP0001672_abnormal_embryogenesis/_devel1.73690991
22MP0005380_embryogenesis_phenotype1.73690991
23MP0000678_abnormal_parathyroid_gland1.73269054
24MP0010307_abnormal_tumor_latency1.72951246
25MP0002080_prenatal_lethality1.65320123
26MP0002163_abnormal_gland_morphology1.62406164
27MP0002085_abnormal_embryonic_tissue1.61789522
28MP0003984_embryonic_growth_retardation1.55446059
29MP0002088_abnormal_embryonic_growth/wei1.51896712
30MP0009379_abnormal_foot_pigmentation1.51369626
31MP0000313_abnormal_cell_death1.50571054
32MP0008877_abnormal_DNA_methylation1.49599424
33MP0002084_abnormal_developmental_patter1.47548022
34MP0004197_abnormal_fetal_growth/weight/1.44455660
35MP0003567_abnormal_fetal_cardiomyocyte1.40338411
36MP0002019_abnormal_tumor_incidence1.40158036
37MP0003315_abnormal_perineum_morphology1.38134652
38MP0003718_maternal_effect1.36758284
39MP0002086_abnormal_extraembryonic_tissu1.35077716
40MP0001293_anophthalmia1.33467730
41MP0004808_abnormal_hematopoietic_stem1.32964526
42MP0000537_abnormal_urethra_morphology1.31797113
43MP0003806_abnormal_nucleotide_metabolis1.30707826
44MP0004185_abnormal_adipocyte_glucose1.28816518
45MP0003121_genomic_imprinting1.28103246
46MP0009333_abnormal_splenocyte_physiolog1.27393937
47MP0004133_heterotaxia1.26426579
48MP0009053_abnormal_anal_canal1.24898201
49MP0004233_abnormal_muscle_weight1.24569869
50MP0003890_abnormal_embryonic-extraembry1.19780821
51MP0001661_extended_life_span1.12673444
52MP0003119_abnormal_digestive_system1.11592494
53MP0002160_abnormal_reproductive_system1.11577580
54MP0006054_spinal_hemorrhage1.09815353
55MP0000703_abnormal_thymus_morphology1.04713613
56MP0002234_abnormal_pharynx_morphology1.04472815
57MP0002653_abnormal_ependyma_morphology1.04278144
58MP0003186_abnormal_redox_activity1.03802157
59MP0005076_abnormal_cell_differentiation1.03320588
60MP0002210_abnormal_sex_determination1.02426192
61MP0000358_abnormal_cell_content/1.01420615
62MP0004147_increased_porphyrin_level1.01406889
63MP0001545_abnormal_hematopoietic_system1.01103877
64MP0005397_hematopoietic_system_phenotyp1.01103877
65MP0003941_abnormal_skin_development1.00506938
66MP0008995_early_reproductive_senescence0.99849665
67MP0000858_altered_metastatic_potential0.99390833
68MP0003385_abnormal_body_wall0.99383867
69MP0002249_abnormal_larynx_morphology0.98919104
70MP0006292_abnormal_olfactory_placode0.97481580
71MP0003763_abnormal_thymus_physiology0.96860553
72MP0002111_abnormal_tail_morphology0.95304818
73MP0001145_abnormal_male_reproductive0.93936180
74MP0001346_abnormal_lacrimal_gland0.92019755
75MP0001881_abnormal_mammary_gland0.89792953
76MP0001727_abnormal_embryo_implantation0.88420048
77MP0000049_abnormal_middle_ear0.88375065
78MP0002722_abnormal_immune_system0.88177757
79MP0005389_reproductive_system_phenotype0.86951139
80MP0002398_abnormal_bone_marrow0.85130676
81MP0001529_abnormal_vocalization0.84425979
82MP0002938_white_spotting0.83391193
83MP0003937_abnormal_limbs/digits/tail_de0.83197413
84MP0000428_abnormal_craniofacial_morphol0.80577988
85MP0009278_abnormal_bone_marrow0.80319416
86MP0005451_abnormal_body_composition0.80152307
87MP0002132_abnormal_respiratory_system0.79045407
88MP0000689_abnormal_spleen_morphology0.78742559
89MP0009672_abnormal_birth_weight0.78507042
90MP0005023_abnormal_wound_healing0.78116625
91MP0005384_cellular_phenotype0.75595556
92MP0000653_abnormal_sex_gland0.74427530
93MP0001915_intracranial_hemorrhage0.72942657
94MP0005623_abnormal_meninges_morphology0.72874260
95MP0001286_abnormal_eye_development0.72654595
96MP0000566_synostosis0.72575255
97MP0002796_impaired_skin_barrier0.72481868
98MP0001853_heart_inflammation0.71039600
99MP0002429_abnormal_blood_cell0.69324528
100MP0008789_abnormal_olfactory_epithelium0.67987719
101MP0005379_endocrine/exocrine_gland_phen0.67752149
102MP0001919_abnormal_reproductive_system0.67403236
103MP0003861_abnormal_nervous_system0.67396144
104MP0001929_abnormal_gametogenesis0.67050962
105MP0001119_abnormal_female_reproductive0.67012272
106MP0000750_abnormal_muscle_regeneration0.66355767
107MP0004858_abnormal_nervous_system0.65784066
108MP0003221_abnormal_cardiomyocyte_apopto0.65482794
109MP0002092_abnormal_eye_morphology0.65037556
110MP0000477_abnormal_intestine_morphology0.64859559
111MP0002751_abnormal_autonomic_nervous0.64564775
112MP0001188_hyperpigmentation0.64173251
113MP0003705_abnormal_hypodermis_morpholog0.63807045
114MP0006035_abnormal_mitochondrial_morpho0.62716360
115MP0005621_abnormal_cell_physiology0.62680840
116MP0002932_abnormal_joint_morphology0.62069276
117MP0003942_abnormal_urinary_system0.60581137
118MP0002161_abnormal_fertility/fecundity0.60279857
119MP0003699_abnormal_female_reproductive0.60195467
120MP0002282_abnormal_trachea_morphology0.58247025
121MP0009703_decreased_birth_body0.56664214
122MP0005501_abnormal_skin_physiology0.56017916
123MP0003566_abnormal_cell_adhesion0.55574973
124MP0008770_decreased_survivor_rate0.55252408
125MP0000432_abnormal_head_morphology0.55158415
126MP0002177_abnormal_outer_ear0.55125085
127MP0002697_abnormal_eye_size0.54507076
128MP0002114_abnormal_axial_skeleton0.54159882
129MP0006036_abnormal_mitochondrial_physio0.52275475

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.13367094
2Abnormality of cells of the erythroid lineage (HP:0012130)4.98364676
3Abnormal number of erythroid precursors (HP:0012131)4.73558797
4Birth length less than 3rd percentile (HP:0003561)4.65074276
5Breast hypoplasia (HP:0003187)3.81424880
6Oral leukoplakia (HP:0002745)3.81143109
7Colon cancer (HP:0003003)3.75666237
8Selective tooth agenesis (HP:0001592)3.59401587
9Macrocytic anemia (HP:0001972)3.49943625
10Progressive muscle weakness (HP:0003323)3.40024767
11Microvesicular hepatic steatosis (HP:0001414)3.39055061
12Pallor (HP:0000980)3.32180224
13Patellar aplasia (HP:0006443)3.29593240
14Abnormality of the anterior horn cell (HP:0006802)3.17522202
15Degeneration of anterior horn cells (HP:0002398)3.17522202
16Aplasia/Hypoplasia of the patella (HP:0006498)3.14777798
17Aplastic anemia (HP:0001915)3.14563390
18Rough bone trabeculation (HP:0100670)3.10679035
19Chromsome breakage (HP:0040012)3.08822249
20Abnormal mitochondria in muscle tissue (HP:0008316)3.04871542
21Carpal bone hypoplasia (HP:0001498)2.99561565
22Medulloblastoma (HP:0002885)2.97199761
23Meckel diverticulum (HP:0002245)2.95543865
24Truncus arteriosus (HP:0001660)2.95018735
25Absent thumb (HP:0009777)2.90120833
26Trismus (HP:0000211)2.88885329
27Acute necrotizing encephalopathy (HP:0006965)2.86398219
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.85935660
29Abnormality of the ileum (HP:0001549)2.82962861
30Abnormality of the preputium (HP:0100587)2.74280449
31Aplasia/Hypoplasia of the sacrum (HP:0008517)2.73964906
32Absent radius (HP:0003974)2.73018041
33Ependymoma (HP:0002888)2.72553740
3411 pairs of ribs (HP:0000878)2.72188270
35Abnormal number of incisors (HP:0011064)2.70998084
36Microretrognathia (HP:0000308)2.70618287
37Acute encephalopathy (HP:0006846)2.70179762
38Abnormality of chromosome stability (HP:0003220)2.69595745
39Premature graying of hair (HP:0002216)2.68676318
40Cerebral hypomyelination (HP:0006808)2.68606600
41Abnormality of glycolysis (HP:0004366)2.63982553
42Neoplasm of the pancreas (HP:0002894)2.61244489
43Absent forearm bone (HP:0003953)2.54163608
44Aplasia involving forearm bones (HP:0009822)2.54163608
45Increased serum pyruvate (HP:0003542)2.53429229
46Agnosia (HP:0010524)2.50444127
47Hepatocellular necrosis (HP:0001404)2.50161599
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.49792135
49Increased CSF lactate (HP:0002490)2.49160453
50Multiple enchondromatosis (HP:0005701)2.45978504
51Abnormality of cochlea (HP:0000375)2.45694972
52Mitochondrial inheritance (HP:0001427)2.43933690
53Rhabdomyosarcoma (HP:0002859)2.39950445
54Horseshoe kidney (HP:0000085)2.38354449
55Abnormal lung lobation (HP:0002101)2.37492082
56Small intestinal stenosis (HP:0012848)2.35079977
57Duodenal stenosis (HP:0100867)2.35079977
58Triphalangeal thumb (HP:0001199)2.34772901
59Ragged-red muscle fibers (HP:0003200)2.34604795
60Atresia of the external auditory canal (HP:0000413)2.31669188
61Supernumerary spleens (HP:0009799)2.30298376
62Tracheoesophageal fistula (HP:0002575)2.25496182
63Missing ribs (HP:0000921)2.25409086
64Myelodysplasia (HP:0002863)2.25341372
65Hepatic necrosis (HP:0002605)2.22984574
66Abnormal trabecular bone morphology (HP:0100671)2.22492412
67Cleft eyelid (HP:0000625)2.20813931
68Hyperthyroidism (HP:0000836)2.20681124
69Short middle phalanx of the 5th finger (HP:0004220)2.20163007
70Cellular immunodeficiency (HP:0005374)2.19889792
71Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.19838279
72Decreased activity of mitochondrial respiratory chain (HP:0008972)2.19838279
73Cerebral edema (HP:0002181)2.16149279
74Glossoptosis (HP:0000162)2.13386678
75Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.12279718
76Duplication of thumb phalanx (HP:0009942)2.11901782
77Bone marrow hypocellularity (HP:0005528)2.11690531
78Abnormality of the fetal cardiovascular system (HP:0010948)2.10963615
79Abnormal umbilical cord blood vessels (HP:0011403)2.10963615
80Single umbilical artery (HP:0001195)2.10963615
81Premature ovarian failure (HP:0008209)2.06705486
82Abnormality of abdominal situs (HP:0011620)2.04842436
83Abdominal situs inversus (HP:0003363)2.04842436
84Increased intramyocellular lipid droplets (HP:0012240)2.03704949
85Cortical dysplasia (HP:0002539)2.03211353
86Abnormal gallbladder physiology (HP:0012438)2.02644634
87Cholecystitis (HP:0001082)2.02644634
88Atrophy/Degeneration involving motor neurons (HP:0007373)2.02547794
89Basal cell carcinoma (HP:0002671)2.02288431
90Slender long bone (HP:0003100)2.02116285
91Progressive macrocephaly (HP:0004481)2.01790356
92Lactic acidosis (HP:0003128)1.99793079
93Impulsivity (HP:0100710)1.99588658
94Abnormality of the duodenum (HP:0002246)1.97324172
95Proximal placement of thumb (HP:0009623)1.96646341
96Abnormality of the umbilical cord (HP:0010881)1.95413396
97Secondary amenorrhea (HP:0000869)1.94364820
98Sloping forehead (HP:0000340)1.93584852
99Insomnia (HP:0100785)1.92008494
100Deviation of the thumb (HP:0009603)1.90798840
101Increased serum lactate (HP:0002151)1.90212649
102Poor head control (HP:0002421)1.89348584
103Abnormality of reticulocytes (HP:0004312)1.88939834
104Hypoplasia of the radius (HP:0002984)1.87996726
105Increased nuchal translucency (HP:0010880)1.87968948
106Exercise intolerance (HP:0003546)1.86573486
107Ectopic kidney (HP:0000086)1.84175643
108Lipid accumulation in hepatocytes (HP:0006561)1.83572836
109Septate vagina (HP:0001153)1.83464630
110Pancytopenia (HP:0001876)1.83202835
111Overriding aorta (HP:0002623)1.82041725
112Neoplasm of the colon (HP:0100273)1.81352011
113Asplenia (HP:0001746)1.81282482
114Aplasia/hypoplasia of the humerus (HP:0006507)1.80729732
115Hypoparathyroidism (HP:0000829)1.80723252
116Squamous cell carcinoma (HP:0002860)1.80669817
117Thrombocytosis (HP:0001894)1.80584215
118Short thumb (HP:0009778)1.79048319
119Morphological abnormality of the inner ear (HP:0011390)1.78301273
120Gout (HP:0001997)1.77779562
121Sparse eyelashes (HP:0000653)1.77021626
122Broad distal phalanx of finger (HP:0009836)1.76923661
123Abnormality of the labia minora (HP:0012880)1.76368438
124High anterior hairline (HP:0009890)1.75940436
125Orthostatic hypotension (HP:0001278)1.75830498
126Urethral obstruction (HP:0000796)1.75559241
127Hypoplasia of the capital femoral epiphysis (HP:0003090)1.73630417
128Type I transferrin isoform profile (HP:0003642)1.73594704
129Overlapping toe (HP:0001845)1.73539045
130Neoplasm of striated muscle (HP:0009728)1.72120956
131Angiofibromas (HP:0010615)1.71355612
132Adenoma sebaceum (HP:0009720)1.71355612
133Abnormality of the tricuspid valve (HP:0001702)1.71149975
134Rib fusion (HP:0000902)1.70477930
135Lymphoma (HP:0002665)1.70028918
136Aplasia/Hypoplasia of the spleen (HP:0010451)1.69705145
137Increased hepatocellular lipid droplets (HP:0006565)1.68223576
138Duplicated collecting system (HP:0000081)1.67098828
139Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.65884008
140Facial cleft (HP:0002006)1.65274463
141Abnormality of the carotid arteries (HP:0005344)1.64950700
142High pitched voice (HP:0001620)1.64946146

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.94725279
2WEE14.21161693
3CDC74.00730756
4EIF2AK13.43509532
5VRK22.99475450
6TESK22.79346635
7NME22.66119126
8SRPK12.63460400
9NEK22.35972341
10TLK12.29156188
11STK162.15088911
12EIF2AK32.14697235
13TTK2.10584781
14SMG12.09031251
15PLK42.06051634
16VRK12.05033553
17NEK11.91538450
18TSSK61.91052307
19PLK11.88023982
20MKNK11.85233463
21ACVR1B1.84410241
22CDK71.76662079
23BRSK21.75258202
24RPS6KA41.74692032
25RPS6KB21.70204929
26PASK1.66103082
27AURKB1.66039323
28TESK11.61068094
29DYRK31.58837226
30SCYL21.55622061
31ATR1.54107785
32KDR1.45701351
33AURKA1.44581009
34MAP3K81.38830344
35PAK41.34083611
36PLK31.31005806
37PIM21.25718415
38MKNK21.24938854
39IRAK31.22911571
40EPHA21.22741130
41CHEK21.20163912
42BRSK11.19070183
43TGFBR11.17219805
44MAP3K101.15588671
45CDK41.11512756
46STK101.10945887
47PBK1.09020890
48CHEK11.06142246
49LIMK11.05886715
50MAP3K111.03624700
51CCNB11.01105317
52CDK121.00414115
53TAF10.99858327
54ICK0.94849202
55STK40.91055708
56LRRK20.89947278
57ZAK0.85606602
58PAK10.82792026
59TRIB30.82558083
60EEF2K0.81162520
61CDK80.79359492
62EIF2AK20.79149832
63NME10.77571555
64CDK20.76416816
65ATM0.75082580
66PIM10.74814200
67CSNK2A20.74562594
68CSNK2A10.73578044
69PDK20.67105380
70MAPKAPK30.66470356
71RAF10.65453385
72ARAF0.64533018
73BRAF0.61376226
74ILK0.59359634
75CSNK1G30.59324800
76RPS6KA50.58231046
77TAOK20.56370118
78LATS20.54388861
79CDK10.53948944
80FLT30.53723776
81PKN20.51050128
82DYRK20.50189397
83MAP4K10.50176114
84KSR20.48527197
85CSNK1A1L0.48193230
86ALK0.47738351
87DAPK10.47685824
88PRKCI0.47589150
89PNCK0.47358599
90BRD40.44309292
91BLK0.44040703
92AKT20.43403403
93CDK90.43067246
94CDK60.41822071
95CLK10.38733471
96CSNK1G10.38544450
97MAP2K30.35633018
98MELK0.35320619
99CSNK1E0.34800433
100MST40.34661759
101DAPK30.32824751
102ABL20.32466333
103PAK20.30832491
104BCKDK0.30302123
105YES10.29659367
106MAPK110.29152029
107MAPKAPK50.29028922
108BTK0.28824978
109MAPK140.27906795
110ERBB40.27093875
111PRKDC0.26969335
112GRK60.24580649
113PRPF4B0.24569077
114CDK11A0.24473368
115MAPKAPK20.21733603
116CDK140.21661562
117MTOR0.20803042
118CDK190.20419595
119FGFR10.18408892
120CDK150.17793844
121CDK180.17728703

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.19157214
2Mismatch repair_Homo sapiens_hsa034304.35497095
3Ribosome_Homo sapiens_hsa030104.31938948
4Proteasome_Homo sapiens_hsa030503.69460928
5Spliceosome_Homo sapiens_hsa030403.59137847
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.47277717
7RNA polymerase_Homo sapiens_hsa030203.22294511
8RNA transport_Homo sapiens_hsa030133.02234362
9Base excision repair_Homo sapiens_hsa034103.01858774
10Homologous recombination_Homo sapiens_hsa034402.99738850
11Nucleotide excision repair_Homo sapiens_hsa034202.95340779
12One carbon pool by folate_Homo sapiens_hsa006702.63123064
13Pyrimidine metabolism_Homo sapiens_hsa002402.60993733
14Cell cycle_Homo sapiens_hsa041102.56700949
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.36691831
16Fanconi anemia pathway_Homo sapiens_hsa034602.05505180
17RNA degradation_Homo sapiens_hsa030181.87339941
18Non-homologous end-joining_Homo sapiens_hsa034501.80810366
19Basal transcription factors_Homo sapiens_hsa030221.67115241
20mRNA surveillance pathway_Homo sapiens_hsa030151.58515304
21p53 signaling pathway_Homo sapiens_hsa041151.53742273
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36032353
23Systemic lupus erythematosus_Homo sapiens_hsa053221.30913555
24Purine metabolism_Homo sapiens_hsa002301.29993342
25Pyruvate metabolism_Homo sapiens_hsa006201.22950697
26Epstein-Barr virus infection_Homo sapiens_hsa051691.17048641
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11893688
28Protein export_Homo sapiens_hsa030601.04101301
29Vitamin B6 metabolism_Homo sapiens_hsa007500.99679866
30Parkinsons disease_Homo sapiens_hsa050120.99361758
31Huntingtons disease_Homo sapiens_hsa050160.97894405
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87130748
33Oocyte meiosis_Homo sapiens_hsa041140.85563245
34* Viral carcinogenesis_Homo sapiens_hsa052030.84012896
35Herpes simplex infection_Homo sapiens_hsa051680.81157108
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80974451
37Antigen processing and presentation_Homo sapiens_hsa046120.80051294
38Folate biosynthesis_Homo sapiens_hsa007900.79324963
39Oxidative phosphorylation_Homo sapiens_hsa001900.78343526
40Fatty acid elongation_Homo sapiens_hsa000620.76379179
41Pentose phosphate pathway_Homo sapiens_hsa000300.76243374
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75507022
43Sulfur relay system_Homo sapiens_hsa041220.74820648
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.74337015
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72768871
46Biosynthesis of amino acids_Homo sapiens_hsa012300.72282081
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.71830771
48* HTLV-I infection_Homo sapiens_hsa051660.68904819
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68896145
50Thyroid cancer_Homo sapiens_hsa052160.63914254
51Glutathione metabolism_Homo sapiens_hsa004800.60532687
52Legionellosis_Homo sapiens_hsa051340.58404531
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.57372626
54Selenocompound metabolism_Homo sapiens_hsa004500.55408827
55Alcoholism_Homo sapiens_hsa050340.50863079
56MicroRNAs in cancer_Homo sapiens_hsa052060.50751099
57Basal cell carcinoma_Homo sapiens_hsa052170.49846364
58Small cell lung cancer_Homo sapiens_hsa052220.49290057
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49055514
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46693030
61Shigellosis_Homo sapiens_hsa051310.45512004
62Hippo signaling pathway_Homo sapiens_hsa043900.45271686
63N-Glycan biosynthesis_Homo sapiens_hsa005100.44706000
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43649807
65Bladder cancer_Homo sapiens_hsa052190.42890280
66Carbon metabolism_Homo sapiens_hsa012000.42241965
67Apoptosis_Homo sapiens_hsa042100.41122260
68TGF-beta signaling pathway_Homo sapiens_hsa043500.40219890
69Cardiac muscle contraction_Homo sapiens_hsa042600.39253226
70Steroid biosynthesis_Homo sapiens_hsa001000.36795520
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36532401
72Alzheimers disease_Homo sapiens_hsa050100.35783913
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33171981
74Arginine and proline metabolism_Homo sapiens_hsa003300.33157637
75Lysine degradation_Homo sapiens_hsa003100.32920187
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32729482
77Colorectal cancer_Homo sapiens_hsa052100.31973143
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31805666
79Primary immunodeficiency_Homo sapiens_hsa053400.31356225
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29568557
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29255541
82Hepatitis B_Homo sapiens_hsa051610.28654741
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27662537
84Hedgehog signaling pathway_Homo sapiens_hsa043400.27633700
85Notch signaling pathway_Homo sapiens_hsa043300.25058529
86Measles_Homo sapiens_hsa051620.24223624
87HIF-1 signaling pathway_Homo sapiens_hsa040660.23398565
88Fructose and mannose metabolism_Homo sapiens_hsa000510.22618049
89Pathways in cancer_Homo sapiens_hsa052000.22471423
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21328202
91Metabolic pathways_Homo sapiens_hsa011000.21081326
92Viral myocarditis_Homo sapiens_hsa054160.20657129
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19909300
94Propanoate metabolism_Homo sapiens_hsa006400.19601405
95Non-small cell lung cancer_Homo sapiens_hsa052230.18838609
96Galactose metabolism_Homo sapiens_hsa000520.18398702
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18314519
98Pancreatic cancer_Homo sapiens_hsa052120.18048334
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17526078
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.17209839
101Fatty acid metabolism_Homo sapiens_hsa012120.17149070
102Chronic myeloid leukemia_Homo sapiens_hsa052200.16487573
103Phenylalanine metabolism_Homo sapiens_hsa003600.14696127
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.14123280
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14115994
106Arginine biosynthesis_Homo sapiens_hsa002200.13742699
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.13320917
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.13182521
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12995061
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.12830562
111Adherens junction_Homo sapiens_hsa045200.12563897
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.12221892
113Renin-angiotensin system_Homo sapiens_hsa046140.12141259
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11996258
115Tyrosine metabolism_Homo sapiens_hsa003500.11112270
116Asthma_Homo sapiens_hsa053100.11057433
117Wnt signaling pathway_Homo sapiens_hsa043100.10225117
118Influenza A_Homo sapiens_hsa051640.09824579
119Hematopoietic cell lineage_Homo sapiens_hsa046400.09538834
120Acute myeloid leukemia_Homo sapiens_hsa052210.08273014
121Melanoma_Homo sapiens_hsa052180.07374181
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.06736052

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